id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288440-w7g2agaf	Jia, Rui	The C-Terminal Sequence of IFITM1 Regulates Its Anti-HIV-1 Activity	2015-03-04		.txt	text/plain	4902	276	53	This inhibition appears to be specific to HIV-1, since neither the WT IFITM1 nor its C-terminal truncations affected entry that was mediated by the G protein of vesicular stomatitis virus (VSV) ( Fig. 2A and 2B) . Removing the last 9 or 14 amino acids from C-terminal sequence re-localized the majority of IFITM1 to the cell periphery (Fig. 3A) , indicating that these C-terminus truncated IFITM1 mutants are mostly positioned at the plasma membrane where HIV-1 entry occurs. We recently reported that HIV-1 BH10 became resistant to IFITM1 restriction in the spread infection through acquiring mutations in viral Env and Vpu proteins that together enhance the virus transmission between cells [27] . One possible scenario is that HIV-1 Env protein may modulate virus sensitivity to human IFITM1 restriction by virtue of its ability to mediate and regulate virus cell-to-cell transmission.	./cache/cord-288440-w7g2agaf.txt	./txt/cord-288440-w7g2agaf.txt