id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287784-f7usy52w	Maestre, Ana M.	Equine Torovirus (BEV) Induces Caspase-Mediated Apoptosis in Infected Cells	2011-06-15		.txt	text/plain	8981	395	45	Based on this finding, we analyzed several apoptotic markers, and observed protein synthesis inhibition, rRNA and DNA degradation, nuclear fragmentation, caspase-mediated cleavage of PARP and eIF4GI, and PKR and eIF2α phosphorylation, all these processes taking place after peak virus production. We did not observe any CPE on the cells treated with UV-inactivated virus (data not shown), and neither of the two caspase substrates was processed in these cells (Fig. 5B) , suggesting that BEV apoptosis triggering is dependent upon viral replication. As a whole, these results indicate that although both cell death receptor and mitochondrial pathways are implicated in the BEV induction of apoptosis, the mitochondrial pathway could be secondarily activated by caspase-8-mediated cleavage of Bid. To further ascertain the involvement of the mitochondrial pathway in BEV-induced apoptosis we analyzed the cellular distribution of cytochrome c at different times postinfection.	./cache/cord-287784-f7usy52w.txt	./txt/cord-287784-f7usy52w.txt