id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284016-zb6cv8ik	Li, Wei	Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection	2008-04-16		.txt	text/plain	4188	258	48	Expression of IL-32 in influenza A virus infected A549 human lung epithelial cells was blocked by either selective COX-2 inhibitor NS398 or Aspirin, a known anti-inflammatory drug, indicating IL-32 was induced through COX-2 in the inflammatory cascade. It has been reported that influenza virus can activate the expression of COX-2 in cell culture systems [26] and that dsRNA can induce the production of COX-2, followed by PGE 2 release [5] . To identify the viral components which play important roles in IV-stimulated pro-inflammatory factors COX-2 and IL-32 expression, we screened all ten proteins of influenza virus: HA, NA, NP, NS1, NS2, M1, M2, PA, PB1, PB2 and poly(IC) (to mimic viral replicative intermediate dsRNA) by luciferase assays. Both influenza A virus infection and poly(IC)+IFN-c treatment in A549 human lung epithelial cells were able to induce COX-2/ IL-32 mRNA and protein expression as well as PGE 2 and IL-32 accumulation in the cell culture supernatants.	./cache/cord-284016-zb6cv8ik.txt	./txt/cord-284016-zb6cv8ik.txt