id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278018-3qemb0x3	Li, Li	Identification of M.tuberculosis-Specific Th1 Cells Expressing CD69 Generated in vivo in Pleural Fluid Cells from Patients with Tuberculous Pleurisy	2011-08-22		.txt	text/plain	5980	332	57	In the present study, we found that without any stimulation, CD4(+) T cells in pleural fluid cells (PFCs) from patients with TBP expressed significantly higher levels of CD69 than PBMCs from patients with tuberculosis (TB) or healthy donors. The phenotypic and functional analysis of CD69-expressing cells strongly suggested that CD69 could be a useful marker for the identification or enrichment of antigen specific Th1 cells at local sites following MTB infection. However, following stimulation with MTB-specific peptides of ESAT-6/CFP-10, CD4 + CD69 + T cells from the same patients expressed high levels of IFN-c, IL-2 and TNF-a (data not shown). However, following stimulation with MTB-specific peptides of ESAT-6/ CFP-10, CD4 + CD69 + T cells from the same patients with tuberculous pleurisy expressed high levels of IFN-c, IL-2 and TNF-a, indicating that the response was MTB-specific.	./cache/cord-278018-3qemb0x3.txt	./txt/cord-278018-3qemb0x3.txt