id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267189-xq70rn1j	Wang, Xinyu	Co-Circulation of Canine Coronavirus I and IIa/b with High Prevalence and Genetic Diversity in Heilongjiang Province, Northeast China	2016-01-15		.txt	text/plain	3037	156	56	To trace the evolution of canine coronavirus (CCoV), 201 stool samples from diarrheic dogs in northeast China were subjected to reverse transcription-polymerase chain reactions (RT-PCRs) targeting the partial M and S genes of CCoV, followed by an epidemiological analysis. Our data provide evidence that CCoV-I, CCoV-IIa, and CCoV-IIb strains co-circulate in the diarrhoetic dogs in northeast China, high co-infection rates with CaKV and CPV-2 were observed, and the CCoV-II strains exhibited high prevalence and genetic diversity. A phylogenetic analysis using partial S gene sequences demonstrated that the 26 CCoV-IIa strains were closely related to three reference strains, 5281 (Japan), TN-449 (USA), and 1086-IIa (Brazil), and differed genetically from reference strains from China and other countries (Fig 2A) . This result demonstrated that vaccination for other canine viruses did not effect CCoV infections in the dog population in Heilongjiang province, northeast China.	./cache/cord-267189-xq70rn1j.txt	./txt/cord-267189-xq70rn1j.txt