id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-263453-7v4y02j6	Nishiura, Hiroshi	Early Epidemiological Assessment of the Virulence of Emerging Infectious Diseases: A Case Study of an Influenza Pandemic	2009-08-31		.txt	text/plain	5350	231	55	We first examine the approach by analyzing an outbreak of severe acute respiratory syndrome in Hong Kong (2003) with known unbiased cCFR estimate, and then investigate published epidemiological datasets of novel swine-origin influenza A (H1N1) virus infection in the USA and Canada (2009). Nevertheless, a much-used crude estimate of the cCFR, i.e. the ratio of the cumulative number of deaths to cases at calendar time t, tends to yield a biased (and mostly underestimated) cCFR due to the time-delay from onset to death [8] ; similar estimates of such a biased cCFR for severe acute respiratory syndrome (SARS) have shown how such estimates can vary substantially as an epidemic progresses, stabilizing only in the later stages of the outbreak [8, 9] . doi:10.1371/journal.pone.0006852.g003 Figure 6 shows the time course of biased cCFR estimates in the USA and Canada based on the reporting date of confirmed cases and deaths to the World Health Organization.	./cache/cord-263453-7v4y02j6.txt	./txt/cord-263453-7v4y02j6.txt