id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255588-nh34lgdh	Guo, Fang	RO 90-7501 Enhances TLR3 and RLR Agonist Induced Antiviral Response	2012-10-03		.txt	text/plain	4776	268	51	Recognition of virus infection by innate pattern recognition receptors (PRRs), including membrane-associated toll-like receptors (TLR) and cytoplasmic RIG-I-like receptors (RLR), activates cascades of signal transduction pathways leading to production of type I interferons (IFN) and proinflammatory cytokines that orchestrate the elimination of the viruses. In our efforts to identify small molecules that selectively enhance PRR-mediated antiviral, but not the detrimental inflammatory response, we discovered a compound, RO 90–7501 ('2'-(4-Aminophenyl)-[2,5′-bi-1H-benzimidazol]-5-amine), that significantly promoted both TLR3 and RLR ligand-induced IFN-β gene expression and antiviral response, most likely via selective activation of p38 mitogen-activated protein kinase (MAPK) pathway. In order to discover compounds with the expected pharmacological property, we set out to establish reporter cell lines for high throughput screening of small molecules that selectively enhance TLR3 ligand-induced IFN-b gene expression, but do not affect NFkB activation, which is a central player in the induction of proinflammatory cytokines, but plays a less prominent role in type I IFN gene expression [25] .	./cache/cord-255588-nh34lgdh.txt	./txt/cord-255588-nh34lgdh.txt