id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255576-738khdwv	Van Duyne, Rachel	Localization and Sub-Cellular Shuttling of HTLV-1 Tax with the miRNA Machinery	2012-07-10		.txt	text/plain	9845	517	56	We have previously shown that Tax interacts directly with the cellular Rb (Retinoblastoma) protein and targets Rb for degradation via the proteasome pathway, resulting in a decrease in Rb protein expression in HTLV-1 infected cells and a dysregulation of the cell cycle [47] . Collectively, these data indicate that the Drosha in Tax-containing and HTLV-1 infected cells is mostly functionally inactive and the functional suppression of Drosha is dependent on its interaction with a small region of the N-terminus of Tax. We have shown above that Drosha is downregulated, degraded, and mostly inactive in HTLV-1 infected cells, however, it was not clear what effect this dysregulation of Drosha would have on viral replication. Collectively, these data indicate that proteins, such as IKK-b, among others, may directly be regulated by the Tax/Drosha interaction in HTLV infected cells.	./cache/cord-255576-738khdwv.txt	./txt/cord-255576-738khdwv.txt