id author title date pages extension mime words sentences flesch summary cache txt cord-048492-4z38v9rg Tang, Julian W. Seasonality of Influenza A(H3N2) Virus: A Hong Kong Perspective (1997–2006) 2008-07-23 .txt text/plain 4458 202 48 In this study, an analysis is presented of 281 Hong Kong influenza A(H3N2) hemagglutinin (HA) and neuraminidase (NA) full-length, dated sequences collected over 10 years (1997-2006) to assist the ongoing efforts to elucidate the underlying basis for the seasonality of influenza A(H3N2). One example of such possible viral persistence between influenza seasons was found, with HA and NA sequences from the same viruses (5251Jan02 and 5267Jan03, as indicated in Figures S1 and S2 for the HA and NA phylogenetic trees, respectively), showing a similar clustering pattern for both these genes, separated by at least one year. A similar analysis was recently performed using dated whole genome influenza A(H3N2) sequences from New York, New Zealand and Australia, downloaded from publicly available databases, in an attempt to test two competing hypotheses: whether seasonal influenza A(H3N2) viruses continuously 'migrate' around the world, particularly between Northern and Southern hemispheres; or whether the virus remains 'latent' in one location and reactivates each year to produce the familiar pattern of influenza seasonality [19] . ./cache/cord-048492-4z38v9rg.txt ./txt/cord-048492-4z38v9rg.txt