id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002890-g7aje88u	Wood, Paul L.	Lipidomic analysis of immune activation in equine leptospirosis and Leptospira-vaccinated horses	2018-02-23		.txt	text/plain	3276	177	39	In this study, we undertook a lipidomics approach to determine if there are any differences in the serum lipid profiles of horses naturally infected with pathogenic Leptospira spp. Utilizing a high-resolution mass spectrometry serum lipidomics analytical platform, we demonstrate that cyclic phosphatidic acids, diacylglycerols, and hydroperoxide oxidation products of choline plasmalogens are elevated in the serum of naturally infected as well as vaccinated horses. In this study, we asked if differences in host's responses to live, multiplying Leptospira versus killed leptospires, present in the vaccine, are reflected in the serum lipidome of these two groups of horses. Our results show that serum levels of cyclic phosphatidic acids (cPA), diacylglycerols, and hydroperoxide oxidation products of choline plasmalogens were elevated in both vaccinated and naturally infected horses. Our data indicate that the immune response induced by vaccination has a more dramatic effect than leptospiral infection on sphingomyelin synthesis in horses.	./cache/cord-002890-g7aje88u.txt	./txt/cord-002890-g7aje88u.txt