id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002305-qq73gr9y	Anson, Marie	Regulation and Maintenance of an Adoptive T-Cell Dependent Memory B Cell Pool	2016-11-23		.txt	text/plain	5422	248	51	In conclusion, the adoptive cell transfer strategy allowed the development of a primary immune response with B cell activation and expansion, induction of AID expression, class switch recombination, antigen-specific IgM and IgG antibody production and germinal center formation. In this study we show that it is possible to fully reconstitute a primary response and the establishment of antibody memory in immune deficient mice after adoptive transfer of antigen-specific monoclonal B cells together with a population of monoclonal helper T cells. In contrast we showed that after adoptive transfer in immune deficient hosts antigen immunization induced B cell activation and expansion, induction of AID expression, class switch recombination, antigen-specific IgM and IgG antibody production, germinal center formation and the generation of two subsets of AID/YFP + IgM + IgGand AID/YFP + Ig-M -IgG + antigen-experienced B cell subsets able to persist in a lymphopenic environment by cell division mimicking responses obtained in intact non-Tg mice [4] .	./cache/cord-002305-qq73gr9y.txt	./txt/cord-002305-qq73gr9y.txt