id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002141-9mxi4dzi	Memczak, Henry	Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding	2016-07-14		.txt	text/plain	8780	476	51	title: Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding We used complementary experimental and theoretical approaches to select HA binding VH-CDR peptides and to improve their potential to inhibit binding, and finally, infection of cells by influenza A virus. Contribution to the total binding free energy change of every amino acid of PeB GF binding to HA of Aichi H3N2 obtained by MD-simulations is shown in Fig 2B. Our aim was to obtain peptide inhibitors that recognize the conserved region of the sialic acid binding pocket of HA with a broader specificity to cover several influenza virus strains. The three CDRs of the VH-chain of antibody HC19 against hemagglutinin of influenza virus Aichi H3N2 were used as templates to design peptides being a potential inhibitor of virus binding to host cells. As a consequence, the hemagglutination inhibition efficiency may not necessarily be stronger against Aichi H3N2, even though the peptide was derived from an antibody binding to this influenza strain.	./cache/cord-002141-9mxi4dzi.txt	./txt/cord-002141-9mxi4dzi.txt