id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001958-2gt3fwpy	Meseda, Clement A.	Percutaneous Vaccination as an Effective Method of Delivery of MVA and MVA-Vectored Vaccines	2016-02-19		.txt	text/plain	8161	361	43	Our data suggest that MVA administered by percutaneous inoculation, elicited vaccinia-specific antibody responses, and protected mice from lethal vaccinia virus challenge, at levels comparable to or better than subcutaneous or intramuscular inoculation. In the work described here, we demonstrate in mouse models that percutaneous inoculation of MVA elicited protective immune responses against lethal intranasal challenge with the Western Reserve (WR) strain of vaccinia virus, and at low doses of MVA, lower morbidity was recorded in mice that were vaccinated via the percutaneous route than in those immunized via the intramuscular or subcutaneous routes. In a preliminary experiment to investigate the utility of the percutaneous route for the delivery of MVA, we observed that MVA delivered by tail scarification, while statistically insignificant (p = 0.298), elicited a higher vaccinia-specific IgG response and protection in mice than the same dose (10 6 pfu) delivered by the intramuscular route (S1 Fig) .	./cache/cord-001958-2gt3fwpy.txt	./txt/cord-001958-2gt3fwpy.txt