id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001716-lbtdex4p	Gilca, Rodica	Mid-Season Estimates of Influenza Vaccine Effectiveness against Influenza A(H3N2) Hospitalization in the Elderly in Quebec, Canada, January 2015	2015-07-22		.txt	text/plain	4070	189	37	Canada's Sentinel Physician Surveillance Network (SPSN) measured vaccine effectiveness (VE) against medically-attended laboratory-confirmed outpatient A(H3N2) illness of -8% (95%CI:-50-23%) overall and 2% (95%CI:-49-36%) in non-elderly (<65-year-old) adults, indicating little or no vaccine protection even among individuals capable of mounting an effective immune response [2] . Although Canadian mid-season inpatient and outpatient VE findings for the 2014/15 season have been consistent with null vaccine effects (statistically non-significant and spanning zero) in both age groups, the CIRN finding of a lower and negative point estimate of VE against A(H3N2) hospitalization in the elderly, more closely broaching statistical significance, warrants further clarification. Multivariable analyses by logistic regression adjusted for age, underlying comorbidity placing individuals at higher risk of influenza-related complications [13] , interval between symptom onset and specimen collection (4 days, 5-7 days), hospital site, epidemic week based on hospital admission date (49-51, 52, 53 and 1-2), and primary residence (community, LTCF or other institutional/group setting).	./cache/cord-001716-lbtdex4p.txt	./txt/cord-001716-lbtdex4p.txt