id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001599-pfdnmzx2	Wee, Yin Shen	Age-Related Onset of Obesity Corresponds with Metabolic Dysregulation and Altered Microglia Morphology in Mice Deficient for Ifitm Proteins	2015-04-09		.txt	text/plain	6017	327	45	Analysis of the gene expression profiles in the hypothalamus of IfitmDel animals, compared to WT, demonstrated an altered ratio of Pomc and Npy neuropeptide expression, which likely impairs the satiation response of the IfitmDel animal leading to an increased eating behavior. As we maintain these animals as homozygous deletion lines, over time we have observed a pronounced enhanced weight gain and an obesity phenotype (e.g., [21] [22] [23] ) in older IfitmDel mice compared to C57BL/6 controls. In this report we quantify the obesity phenotype and link this to altered leptin/neuropeptide signaling, and demonstrate abnormal microglia morphology in the IfitmDel animal. Based upon the previously described findings that the absence of the Ifitm proteins can alter cellular induction pathways following type I interferon treatment, we tested whether or not the IfitmDel animals would have an altered response, compared to WT, to chronic Poly I:C treatment.	./cache/cord-001599-pfdnmzx2.txt	./txt/cord-001599-pfdnmzx2.txt