id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001432-d4zavkcn	Nishida, Yoriko	Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry	2014-10-16		.txt	text/plain	5268	306	48	PROCEDURES: Proteins expressed in the islets of enterovirus-associated fulminant type 1 diabetes (FT1DM) with extensive insulitis were identified by laser-capture microdissection mass spectrometry using formalin-fixed paraffin-embedded pancreatic tissues. Migratory activity-related proteins, including plastin-2 (LCP1), moesin (MSN), lamin-B1 (LMNB1), Ras GTPase-activating-like protein (IQGAP1) and others, were identified in CD8(+) T cells and CD68(+) macrophages infiltrated to inflamed FT1DM islets. Proteins involved in successive signaling in innate/adaptive immunity were identified, including SAM domain and HD domain-containing protein 1 (SAMHD1), Ras GTPase-activating-like protein (IQGAP1), proteasome activator complex subunit 1 (PSME1), HLA class I histocompatibility antigen (HLA-C), and signal transducer and activator of transcription 1-alpha/beta (STAT1). Actin-related protein 3 (ACTR3) was over-expressed in the cytoplasm and nucleus of MNCs infiltrated to the islets in FT1DM-affected pancreas tissue. Signal transducer and activator of transcription 1-alpha/beta (STAT1) was highly expressed in islet endocrine cells and MNCs in FT1DM tissue ( Figure 2Q, R) .	./cache/cord-001432-d4zavkcn.txt	./txt/cord-001432-d4zavkcn.txt