id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001363-irysq6pf	Liu, Zhenjiang	SELDI-TOF-MS Proteomic Profiling of Serum, Urine, and Amniotic Fluid in Neural Tube Defects	2014-07-23		.txt	text/plain	5113	271	49	Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) is a breakthrough in clinical proteomics, and can detect different protein expression patterns of body fluid and tissue specimens between patients and healthy subjects, and its rapid development provides an alternative tool to search for biomarkers. The purpose of this pilot study was to preliminarily explore the differential protein expression pattern between NTD case mothers and normal control mothers using SELDI-TOF-MS protein profiling and Classification and Regression Tree (CART) analysis, in order to differentiate pregnancies complicated by the presence of an NTD-affected fetus from healthy controls. Analysis of amniotic fluid samples from mothers of NTDaffected fetuses and normal control mothers revealed two major, differentially expressed proteins at 14700 and 13776 Da used in the classification pattern to generate 3 terminal nodes (Fig. 7) . However, when we analyzed the data, we found that only four protein/peptide biomarkers, 4188, 6451, 11744 and 23425 Da, were detected in all serum, urine and amniotic fluid samples.	./cache/cord-001363-irysq6pf.txt	./txt/cord-001363-irysq6pf.txt