id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001359-c1uom5f7	Oslund, Karen L.	Synergistic Up-Regulation of CXCL10 by Virus and IFN γ in Human Airway Epithelial Cells	2014-07-17		.txt	text/plain	4567	290	53	In this study, we demonstrate the synergistic stimulation of CXCL10 mRNA and protein, a key chemokine responsible for the early immune response to viral infection, following treatment of airway epithelial cells with IFN γ and influenza virus. Therefore, we conclude that IFN γ and dsRNA act in concert to potentiate CXCL10 expression in airway epithelial cells via an NFκB-dependent but IFNAR-STAT independent pathway and it is at least partly regulated at the transcriptional level. In this study, we demonstrate synergistic induction of CXCL10 in well differentiated primary human bronchial epithelial (HBE) cells following influenza virus infection and the treatment with IFN c. As shown in Fig. 1A , well differentiated HBE cells demonstrated significant synergistic induction of CXCL10 mRNA following infection with the MEM influenza virus and treatment with IFN c. These results demonstrate that influenza virus in combination with IFN c synergistically induce CXCL10 mRNA and protein production from primary human airway epithelial cells.	./cache/cord-001359-c1uom5f7.txt	./txt/cord-001359-c1uom5f7.txt