id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001275-a9o2dvke	Chen, Xue	A Vaccine of L2 Epitope Repeats Fused with a Modified IgG1 Fc Induced Cross-Neutralizing Antibodies and Protective Immunity against Divergent Human Papillomavirus Types	2014-05-06		.txt	text/plain	5558	254	47	title: A Vaccine of L2 Epitope Repeats Fused with a Modified IgG1 Fc Induced Cross-Neutralizing Antibodies and Protective Immunity against Divergent Human Papillomavirus Types Current human papillomavirus (HPV) major capsid protein L1 virus-like particles (VLPs)-based vaccines in clinic induce strong HPV type-specific neutralizing antibody responses. To develop pan-HPV vaccines, here, we show that the fusion protein E3R4 consisting of three repeats of HPV16 L2 aa 17–36 epitope (E3) and a modified human IgG1 Fc scaffold (R4) induces cross-neutralizing antibodies and protective immunity against divergent HPV types. In this study, we showed for the first time that fusing HPV16 L2 aa 17-36 epitope repeats to a recombinant ligand for FccRs (designated L2R4, see Figure 1A -B) could significantly increase the immunogenicity of the L2 peptide and induce cross-neutralizing antibodies and protective immunity against a range of phylogenetically distant HPV types.	./cache/cord-001275-a9o2dvke.txt	./txt/cord-001275-a9o2dvke.txt