id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001263-hqxiyxfj	Kam, Yiu-Wing	Unique Epitopes Recognized by Antibodies Induced in Chikungunya Virus-Infected Non-Human Primates: Implications for the Study of Immunopathology and Vaccine Development	2014-04-22		.txt	text/plain	5676	282	46	title: Unique Epitopes Recognized by Antibodies Induced in Chikungunya Virus-Infected Non-Human Primates: Implications for the Study of Immunopathology and Vaccine Development In addition to the anti-E2 glycoprotein responses, we also identified new linear B-cell epitopes that were recognized by anti-CHIKV antibodies from CHIKV-infected macaques. Results showed two structural proteins (Capsid protein and E2 glycoprotein) and three nonstructural proteins (nsP1, nsP3 and nsP4 proteins) contained linear epitopes that were recognized by macaque anti-CHIKV antibodies. Here, E2EP3 is one of the major B-cell linear epitopes recognized by antibodies from the sera of all CHIKV-infected macaques during the early phase of disease (amino acids 2800-2818, Table 1 ). Infection of macaques with the LR2006-OPY1 isolate, which encodes K 252 in the E2 glycoprotein, strongly induced anti-CHIKV antibodies against a particular linear B-cell epitope (amino acids 3025-3066) at 16 dpi.	./cache/cord-001263-hqxiyxfj.txt	./txt/cord-001263-hqxiyxfj.txt