id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001254-y2knt8g0	Parkhomenko, Taisiya A.	Comparison of DNA-Hydrolyzing Antibodies from the Cerebrospinal Fluid and Serum of Patients with Multiple Sclerosis	2014-04-15		.txt	text/plain	6739	325	50	Here we have shown, for the first time, that average concentration of total proteins (132-fold), total IgGs (194-fold) and anti-DNA antibodies (200-fold) in the sera is significantly higher than that in the cerebrospinal fluid (CSF) of fifteen MS patients. We present first evidence showing that IgGs from CSF not only bind but efficiently hydrolyze DNA and that average specific DNase activity of homogeneous antibodies from CSF is unpredictably ∼49-fold higher than that from the sera of the same MS patients. Finally, the relative concentration of total anti-DNA Abs correlated with the relative specific IgG DNase activity better in the sera (CC = +0.51; columns 6 and 12) than in CSF (CC = + 0.11; columns 5 and 11) (Tables 2 and 3 ).	./cache/cord-001254-y2knt8g0.txt	./txt/cord-001254-y2knt8g0.txt