id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001249-awn9ayy6	Lasecka, Lidia	The Nairovirus Nairobi Sheep Disease Virus/Ganjam Virus Induces the Translocation of Protein Disulphide Isomerase-Like Oxidoreductases from the Endoplasmic Reticulum to the Cell Surface and the Extracellular Space	2014-04-08		.txt	text/plain	9953	453	50	ERp57 while the structure of the ER, ERGIC and Golgi remains unchanged Two isolates of NSDV have been previously described by us [29] : a multiple-times passaged isolate of NSDV from Uganda, which appeared attenuated upon infection of a susceptible animal, and an isolate of GV from India which had been passaged a limited number of times in mouse brain or BHK21 clone 13 cells and which caused haemorrhagic gastroenteritis in sheep upon experimental inoculation. No change to the cellular distribution of calnexin was observed (Figure 2 j-l), indicating that, despite the disappearance of PDI and ERp57, the overall structure of the ER remains unchanged in NSDV-infected cells. Another flavivirus, Dengue virus (DENV) (which, like NSDV, can cause a haemorrhagic fever), increased surface levels of PDI in infected endothelial cells [86] . In this study we have demonstrated that NSDV induces the redistribution of soluble ER oxidoreductases, specifically PDI and ERp57, in infected cells, and that the viral PreGn glycoprotein appears to be involved in this process.	./cache/cord-001249-awn9ayy6.txt	./txt/cord-001249-awn9ayy6.txt