id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001129-gi2kswai	Lemos de Matos, Ana	Positive Evolutionary Selection On the RIG-I-Like Receptor Genes in Mammals	2013-11-27		.txt	text/plain	6978	342	47	Because viruses are responsible for a great number of severe and lethal diseases, together with the important role that RLRs play in mammalian innate immune system, we expect that RIG-I, MDA5 and LGP2 genes may have been under intense selective pressures in all mammals. Evidence for positive selection on mammalian orthologous for RIG-I ( Figure S7 ), MDA5 ( Figure S8 ) and LGP2 ( Figure S9 ) genes was detected using PAML package [54, 55] site-specific models M1a versus M2a and M7 versus M8. (C) Positively-selected codons are exhibited in the table and numbered according to the mammalian LGP2 deduced protein sequences alignment ( Figure S6 downstream RIG-I and MDA5 signaling, which implies functional constraints, the observed variability across species can be perceived as a great structural plasticity for mammalian CARDs. The helicase domain in the RLR family is generally described as exhibiting affinity for dsRNA [78] .	./cache/cord-001129-gi2kswai.txt	./txt/cord-001129-gi2kswai.txt