id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001099-jirkkkvy	Yousuf, Mohammad A.	Caveolin-1 Associated Adenovirus Entry into Human Corneal Cells	2013-10-11		.txt	text/plain	7110	372	46	Collectively, these experiments indicate for the first time that HAdV-D37 uses a lipid raft mediated caveolin-1 associated pathway for entry into corneal cells, and connects the processes of viral entry with downstream proinflammatory cell signaling. Initial binding is followed by a secondary interaction between the arginine-glycine-aspartic acid (RGD) motif in the viral capsid penton base and cellular integrins α v β 3 , α v β 5, and α V β 1 [42] [43] [44] [45] This secondary interaction is thought to induce a host cell signaling cascade resulting in clathrin mediated endocytosis [46] [47] [48] , and possibly, activation of the rab5 dependent classical endosomal pathway [49] . Herein, we show that HAdV-D37, an etiologic agent of epidemic keratoconjunctivitis, enters primary human corneal fibroblasts predominantly via lipid rafts and caveolae, suggesting both redundancy and cell specificity in mechanisms of adenoviral entry. To further examine the role of lipid raft microdomains in HAdV-D37 entry, we treated corneal cells with both Cy3-labeled virus and 488-CTXB, and tracked their cellular localization over time ( Figure 1C ).	./cache/cord-001099-jirkkkvy.txt	./txt/cord-001099-jirkkkvy.txt