id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001014-8yrpcl94	Kitagawa, Hiroshi	Intranasally Administered Antigen 85B Gene Vaccine in Non-Replicating Human Parainfluenza Type 2 Virus Vector Ameliorates Mouse Atopic Dermatitis	2013-07-03		.txt	text/plain	4451	288	57	title: Intranasally Administered Antigen 85B Gene Vaccine in Non-Replicating Human Parainfluenza Type 2 Virus Vector Ameliorates Mouse Atopic Dermatitis Ear swelling, dermal cell infiltrations and serum IgE level were significantly suppressed in the rhPIV2/Ag85B treated mouse group accompanied with elevated IFN-γ and IL-10 mRNA expressions, and suppressed IL-4, TNF-α and MIP-2 mRNA expressions. Expression of IL-4 mRNA was significantly decreased in the ear skin of intra-nasally rhPIV2/Ag85B treatment group compared to that of PBS treated mice (Fig. 4A) . mRNA expressions of TNF-a and MIP-2 were significantly decreased in both of intra-nasally and subcutaneously rhPIV2/Ag85B treated groups compared with PBS or vector treated group (Fig. 4E, F) . Ag85B is a conserved protein in mycobacterial species and can elicit a strong Th1-type immune Expressions of IL-4, TNF-a and MIP2-a mRNA were significantly decreased in the ear skin treated with intranasally rhPIV2/Ag85B treated group compared to those of control groups.	./cache/cord-001014-8yrpcl94.txt	./txt/cord-001014-8yrpcl94.txt