id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000638-ss1435el	Beq, Stephanie	Altered Thymic Function during Interferon Therapy in HCV-Infected Patients	2012-04-16		.txt	text/plain	5142	237	47	The evolution of T-cell subsets and T-cell homeostasis were estimated by flow cytometry while thymic function was measured through quantification of T-cell receptor excision circles (TREC) and estimation of intrathymic precursor T-cell proliferation during the first four months following the initiation of IFNα therapy. In contrast, Arizcorreta and colleagues showed that IFNa and ribavirin therapy induces a substantial reduction of circulating sjTRECs, in HIV/HCV co-infected patients, accompanied by sustained naïve CD4 + T-cell defect, suggesting thymic dysfunction [10] . While the number of RTEs was similar in HCV-infected patients at study entry and healthy individuals ( These data demonstrate that, as early as one month following treatment initiation, IFNa induces stronger alterations of naïve Tcell subsets, and more specifically in the RTE compartment than in any other T-cell subset, suggesting a specific effect on thymopoiesis.	./cache/cord-000638-ss1435el.txt	./txt/cord-000638-ss1435el.txt