id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000580-dcid9emx	Sällman Almén, Markus	The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members	2012-02-20		.txt	text/plain	4662	237	48	We show that the IFITM genes are a subfamily in a larger family of transmembrane (TM) proteins that we call Dispanins, which refers to a common 2TM structure. We mined 36 eukaryotic species, covering all major eukaryotic groups, and found that the IFITMs form a subfamily in a larger novel family that has ten human members in addition to the four IFITM genes. By combining the results of the phylogenetic analysis and BLAST classification, we created a schematic overview of the organisms' gene repertoire and a schematic picture of the Dispanin family's evolutionary history, which suggests that the invertebrate Dispanins share more similarity towards the DSPC and D subfamilies than DSPA and B ( Figure 2 ). We provide evidence that the four IFITM genes together with ten additional human genes, known as TUSC5, TMEM233, PRRT2, TMEM90A, DSPC2, TMEM90B, TMEM91, AC023157, AL160276 and AC068580, form a novel gene family that we call the Dispanins, which refers to the 2TM membrane topology that is common to all identified members.	./cache/cord-000580-dcid9emx.txt	./txt/cord-000580-dcid9emx.txt