id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000265-llilwq1u	Gao, Rongbao	A Systematic Molecular Pathology Study of a Laboratory Confirmed H5N1 Human Case	2010-10-12		.txt	text/plain	4896	253	46	Autopsy studies have shown that human highly pathogenic avian influenza virus (H5N1) can infect multiple human organs other than just the lungs, and that possible causes of organ damage are either viral replication and/or dysregulation of cytokines and chemokines. Although H5N1 virus infection of humans is primarily one of the lower respiratory tract, more recent reports suggested that influenza A H5N1 may in rare, severe cases, disseminate beyond the lungs and infect brain [26, 27] , intestines [20, 27] and lymphoid tissues [27] , and result in extra-pulmonary clinical manifestations including encephalopathy or encephalitis [15, 28] . To better understand the pathogenesis of human H5N1 virus infection, and investigate the route of virus dissemination in vivo, we report on the use of different techniques to detect virus distribution and infection of 5 organ systems in a laboratory confirmed fatal human H5N1 virus infection, and analyze the relationship between viral load in tissues and host response.	./cache/cord-000265-llilwq1u.txt	./txt/cord-000265-llilwq1u.txt