id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321352-174q2pjw	Lew, Qiao Jing	PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription	2010-09-04		.txt	text/plain	5811	302	51	Further induction (more than 2-fold) of the XBP-1S-mediated activation of HTLV-1 and BiP promoters was detected in the PCAF-expressing cells ( Figure 3A and B) . Co-transfection of the PCAF shRNA in the XBP-1S-expressing cells led to 35, 74 and 52% inhibition of BiP, CHOP, and EDEM transcription, respectively ( Figure 6B ), demonstrating the involvement of PCAF in the XBP-1S-dependent transcription. In the XBP-1S/PCAF co-transfected cells, more XBP-1S proteins were found to bind to the promoter region of BiP and CHOP genes ( Figure 7A and B). This observation could explain why CREB1 and other CREB/ATF family proteins fail to up-regulate HTLV-1 transcription in the absence of Tax. In contrast, the requirement for PCAF in the XBP-1S-dependent HTLV-1 basal transcription was clearly demonstrated in the cell-based reporter assays ( Figures 3A and 4A) .	./cache/cord-321352-174q2pjw.txt	./txt/cord-321352-174q2pjw.txt