id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-263645-wupre5uj	Morgan, Brittany S	Insights into the development of chemical probes for RNA	2018-09-19		.txt	text/plain	7104	341	43	One important example is the development of chemical probes, which has greatly progressed the study of proteins and related diseases (11, 12) but has been challenging for non-ribosomal RNAs. This powerful chemical tool requires small molecules with well-defined biological activity, cell permeability, and selectivity to accurately and reliably probe specific mechanistic and phenotypic questions (11, 12) . While ligands that bind non-ribosomal RNA in vitro have been reported for decades, the development of chemical probes with evidence of specific small molecule:RNA engagement in cell or animal models has dramatically increased in the last four years. Recent studies report several drug-like small molecules that target a range of RNAs in animal models, including riboswitches (15) , miRNAs, (16, 17) splice sites (18) , and mature mRNAs (19) , at least one of which is currently in clinical trials (NCT02268552).	./cache/cord-263645-wupre5uj.txt	./txt/cord-263645-wupre5uj.txt