id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330253-9sqizkio	Mowaka, Shereen	Enhanced Extraction Technique of Omarigliptin from Human Plasma—Applied to Biological Samples from Healthy Human Volunteers	2020-09-15		.txt	text/plain	4095	212	48	Six different batches of blank human plasma, OTN raw material (99.0%), Alogliptin raw material, internal standard (IS) (99.2%), Marizev ® (12.5 mg) tablets, tertiary butyl methyl ether (TBME), diethyl ether (DEE) were kindly donated by the British University in Egypt (CDRD, BUE) based on previous research collaborations (Repositioning CDRD-BUE project). Therefore, an advanced analytical technique and enhanced extraction of drugs from human plasma become a challenging approach that greatly affects pharmacokinetics, other clinical studies based on the drug C min and C max values and the bio-analytical methods sensitivity. The authors mentioned in the current study modified the rats' plasma method [18] in another repositioning publication [11] but with direct precipitation with acetonitrile, the LLOQ was 50 ng/mL which is very high in comparison to the LLOQ in the current work with the enhanced extraction technique (9.98 ng/mL equivalent to 25 nM).	./cache/cord-330253-9sqizkio.txt	./txt/cord-330253-9sqizkio.txt