id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310268-8q4tk6fd	Zhu, Qinchang	DNA Aptamers in the Diagnosis and Treatment of Human Diseases	2015-11-25		.txt	text/plain	8649	411	47	Nucleic acid aptamers are RNA and single-stranded (ss) DNA oligonucleotides with lengths typically ranging from 15 to 70 mers, which have the same level of target-binding affinity as monoclonal antibodies (the dissociation constant (K d ) usually ranges from 0.1 to 50 nM) [5, 6] . This SELEX is able to generate DNA aptamers that recognize the cell-surface or intracellular target protein in their native conformation, which shows great potential in cell-specific therapeutics and diagnostic applications [26] [27] [28] . Recently, modified cell-SELEX methods have been developed to select aptamers targeting specific cells like disease state cells and metastatic cells. In the era of personalized medicine, DNA aptamer-based therapeutics and diagnostics are believed to have great potential for extensive application because of their flexibility to specifically bind to any molecule targets.	./cache/cord-310268-8q4tk6fd.txt	./txt/cord-310268-8q4tk6fd.txt