id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287123-ldkuwcc7	He, Hui-Qiong	The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition	2017-03-13		.txt	text/plain	13736	705	41	The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as inflammatory responses including cell adhesion, directed migration, granule release and superoxide production. N-formylated peptides constitute the most commonly studied class of FPR agonists that trigger a variety of biological activities in myeloid cells, such as chemokinesis, chemotaxis, calcium flux, cytokine production and superoxide anion generation. Through binding with the high affinity receptor FPR1, fMLF and other N-formylated peptides serve as potent chemoattractants, which also include activated complements (C5a, C3a) and chemokines, in recruiting and guiding leukocytes to the site of bacterial infection and to damaged tissues. As the first identified endogenous peptide agonist for FPR [56] , documented studies have shown that it exerts pro-inflammatory activities through FPR2 in phagocytes, epithelial cells and T lymphocytes, including stimulating production of inflammatory mediators and enhancing the expression of cytokine receptors [109] [110] [111] [112] [113] .	./cache/cord-287123-ldkuwcc7.txt	./txt/cord-287123-ldkuwcc7.txt