id sid tid token lemma pos cord-312912-i1yyz5lg 1 1 key key NN cord-312912-i1yyz5lg 1 2 : : : cord-312912-i1yyz5lg 2 1 cord-312912-i1yyz5lg cord-312912-i1yyz5lg IN cord-312912-i1yyz5lg 2 2 authors author NNS cord-312912-i1yyz5lg 2 3 : : : cord-312912-i1yyz5lg 2 4 Bou Bou NNP cord-312912-i1yyz5lg 2 5 Khalil Khalil NNP cord-312912-i1yyz5lg 2 6 , , , cord-312912-i1yyz5lg 2 7 Rami Rami NNP cord-312912-i1yyz5lg 2 8 title title NN cord-312912-i1yyz5lg 2 9 : : : cord-312912-i1yyz5lg 2 10 Lithium lithium NN cord-312912-i1yyz5lg 2 11 chloride chloride NN cord-312912-i1yyz5lg 2 12 combination combination NN cord-312912-i1yyz5lg 2 13 with with IN cord-312912-i1yyz5lg 2 14 rapamycin rapamycin NNS cord-312912-i1yyz5lg 2 15 for for IN cord-312912-i1yyz5lg 2 16 the the DT cord-312912-i1yyz5lg 2 17 treatment treatment NN cord-312912-i1yyz5lg 2 18 of of IN cord-312912-i1yyz5lg 2 19 COVID-19 COVID-19 NNP cord-312912-i1yyz5lg 2 20 pneumonia pneumonia NN cord-312912-i1yyz5lg 2 21 date date NN cord-312912-i1yyz5lg 2 22 : : : cord-312912-i1yyz5lg 2 23 2020 2020 CD cord-312912-i1yyz5lg 2 24 - - HYPH cord-312912-i1yyz5lg 2 25 05 05 CD cord-312912-i1yyz5lg 2 26 - - HYPH cord-312912-i1yyz5lg 2 27 01 01 CD cord-312912-i1yyz5lg 2 28 journal journal NN cord-312912-i1yyz5lg 2 29 : : : cord-312912-i1yyz5lg 3 1 Med Med NNP cord-312912-i1yyz5lg 3 2 Hypotheses Hypotheses NNP cord-312912-i1yyz5lg 3 3 DOI DOI NNP cord-312912-i1yyz5lg 3 4 : : : cord-312912-i1yyz5lg 3 5 10.1016 10.1016 CD cord-312912-i1yyz5lg 3 6 / / SYM cord-312912-i1yyz5lg 3 7 j.mehy.2020.109798 j.mehy.2020.109798 NN cord-312912-i1yyz5lg 3 8 sha sha NNP cord-312912-i1yyz5lg 3 9 : : : cord-312912-i1yyz5lg 4 1 7e86213e9c7b928dedde4b881e36a5e2c80108f7 7e86213e9c7b928dedde4b881e36a5e2c80108f7 LS cord-312912-i1yyz5lg 4 2 doc_id doc_id CD cord-312912-i1yyz5lg 4 3 : : : cord-312912-i1yyz5lg 5 1 312912 312912 CD cord-312912-i1yyz5lg 5 2 cord_uid cord_uid NN cord-312912-i1yyz5lg 5 3 : : : cord-312912-i1yyz5lg 6 1 i1yyz5lg i1yyz5lg NNP cord-312912-i1yyz5lg 6 2 nan nan NNP cord-312912-i1yyz5lg 6 3 Dear Dear NNP cord-312912-i1yyz5lg 6 4 Sir Sir NNP cord-312912-i1yyz5lg 6 5 , , , cord-312912-i1yyz5lg 6 6 The the DT cord-312912-i1yyz5lg 6 7 current current JJ cord-312912-i1yyz5lg 6 8 rapid rapid JJ cord-312912-i1yyz5lg 6 9 spread spread NN cord-312912-i1yyz5lg 6 10 of of IN cord-312912-i1yyz5lg 6 11 the the DT cord-312912-i1yyz5lg 6 12 coronavirus coronavirus NN cord-312912-i1yyz5lg 6 13 disease disease NN cord-312912-i1yyz5lg 6 14 ( ( -LRB- cord-312912-i1yyz5lg 6 15 COVID-19 covid-19 VB cord-312912-i1yyz5lg 6 16 ) ) -RRB- cord-312912-i1yyz5lg 6 17 originating originate VBG cord-312912-i1yyz5lg 6 18 from from IN cord-312912-i1yyz5lg 6 19 Wuhan Wuhan NNP cord-312912-i1yyz5lg 6 20 , , , cord-312912-i1yyz5lg 6 21 China China NNP cord-312912-i1yyz5lg 6 22 , , , cord-312912-i1yyz5lg 6 23 has have VBZ cord-312912-i1yyz5lg 6 24 been be VBN cord-312912-i1yyz5lg 6 25 recently recently RB cord-312912-i1yyz5lg 6 26 declared declare VBN cord-312912-i1yyz5lg 6 27 a a DT cord-312912-i1yyz5lg 6 28 pandemic pandemic NN cord-312912-i1yyz5lg 6 29 by by IN cord-312912-i1yyz5lg 6 30 the the DT cord-312912-i1yyz5lg 6 31 world world NNP cord-312912-i1yyz5lg 6 32 health health NNP cord-312912-i1yyz5lg 6 33 organization organization NNP cord-312912-i1yyz5lg 6 34 [ [ -LRB- cord-312912-i1yyz5lg 6 35 1 1 CD cord-312912-i1yyz5lg 6 36 ] ] -RRB- cord-312912-i1yyz5lg 6 37 . . . cord-312912-i1yyz5lg 7 1 Meanwhile meanwhile RB cord-312912-i1yyz5lg 7 2 the the DT cord-312912-i1yyz5lg 7 3 number number NN cord-312912-i1yyz5lg 7 4 of of IN cord-312912-i1yyz5lg 7 5 deceased deceased JJ cord-312912-i1yyz5lg 7 6 individuals individual NNS cord-312912-i1yyz5lg 7 7 from from IN cord-312912-i1yyz5lg 7 8 COVID-19 COVID-19 NNP cord-312912-i1yyz5lg 7 9 has have VBZ cord-312912-i1yyz5lg 7 10 been be VBN cord-312912-i1yyz5lg 7 11 exponentially exponentially RB cord-312912-i1yyz5lg 7 12 increasing increase VBG cord-312912-i1yyz5lg 7 13 . . . cord-312912-i1yyz5lg 8 1 Any any DT cord-312912-i1yyz5lg 8 2 live live RB cord-312912-i1yyz5lg 8 3 - - HYPH cord-312912-i1yyz5lg 8 4 attenuated attenuate VBN cord-312912-i1yyz5lg 8 5 vaccines vaccine NNS cord-312912-i1yyz5lg 8 6 may may MD cord-312912-i1yyz5lg 8 7 take take VB cord-312912-i1yyz5lg 8 8 time time NN cord-312912-i1yyz5lg 8 9 and and CC cord-312912-i1yyz5lg 8 10 give give VB cord-312912-i1yyz5lg 8 11 a a DT cord-312912-i1yyz5lg 8 12 low low JJ cord-312912-i1yyz5lg 8 13 level level NN cord-312912-i1yyz5lg 8 14 of of IN cord-312912-i1yyz5lg 8 15 cross cross JJ cord-312912-i1yyz5lg 8 16 - - JJ cord-312912-i1yyz5lg 8 17 strain strain JJ cord-312912-i1yyz5lg 8 18 immunity immunity NN cord-312912-i1yyz5lg 8 19 which which WDT cord-312912-i1yyz5lg 8 20 renders render VBZ cord-312912-i1yyz5lg 8 21 the the DT cord-312912-i1yyz5lg 8 22 research research NN cord-312912-i1yyz5lg 8 23 for for IN cord-312912-i1yyz5lg 8 24 effective effective JJ cord-312912-i1yyz5lg 8 25 antiviral antiviral JJ cord-312912-i1yyz5lg 8 26 agents agent NNS cord-312912-i1yyz5lg 8 27 a a DT cord-312912-i1yyz5lg 8 28 high high JJ cord-312912-i1yyz5lg 8 29 necessity necessity NN cord-312912-i1yyz5lg 8 30 . . . cord-312912-i1yyz5lg 9 1 Lithium lithium NN cord-312912-i1yyz5lg 9 2 chloride chloride NN cord-312912-i1yyz5lg 9 3 is be VBZ cord-312912-i1yyz5lg 9 4 a a DT cord-312912-i1yyz5lg 9 5 known know VBN cord-312912-i1yyz5lg 9 6 efficacious efficacious JJ cord-312912-i1yyz5lg 9 7 treatment treatment NN cord-312912-i1yyz5lg 9 8 for for IN cord-312912-i1yyz5lg 9 9 bipolar bipolar JJ cord-312912-i1yyz5lg 9 10 disorder disorder NN cord-312912-i1yyz5lg 9 11 mainly mainly RB cord-312912-i1yyz5lg 9 12 because because IN cord-312912-i1yyz5lg 9 13 of of IN cord-312912-i1yyz5lg 9 14 its -PRON- PRP$ cord-312912-i1yyz5lg 9 15 direct direct JJ cord-312912-i1yyz5lg 9 16 inhibition inhibition NN cord-312912-i1yyz5lg 9 17 on on IN cord-312912-i1yyz5lg 9 18 glycogen glycogen NN cord-312912-i1yyz5lg 9 19 synthase synthase NN cord-312912-i1yyz5lg 9 20 kinase kinase NN cord-312912-i1yyz5lg 9 21 3β 3β NNP cord-312912-i1yyz5lg 9 22 , , , cord-312912-i1yyz5lg 9 23 a a DT cord-312912-i1yyz5lg 9 24 phosphorylating phosphorylate VBG cord-312912-i1yyz5lg 9 25 and and CC cord-312912-i1yyz5lg 9 26 inactivating inactivate VBG cord-312912-i1yyz5lg 9 27 agent agent NN cord-312912-i1yyz5lg 9 28 of of IN cord-312912-i1yyz5lg 9 29 glycogen glycogen NNP cord-312912-i1yyz5lg 9 30 synthase synthase NN cord-312912-i1yyz5lg 9 31 involved involve VBN cord-312912-i1yyz5lg 9 32 in in IN cord-312912-i1yyz5lg 9 33 energy energy NN cord-312912-i1yyz5lg 9 34 metabolism metabolism NN cord-312912-i1yyz5lg 9 35 , , , cord-312912-i1yyz5lg 9 36 neuronal neuronal JJ cord-312912-i1yyz5lg 9 37 cell cell NN cord-312912-i1yyz5lg 9 38 development development NN cord-312912-i1yyz5lg 9 39 , , , cord-312912-i1yyz5lg 9 40 and and CC cord-312912-i1yyz5lg 9 41 body body NN cord-312912-i1yyz5lg 9 42 pattern pattern NN cord-312912-i1yyz5lg 9 43 formation formation NN cord-312912-i1yyz5lg 9 44 [ [ -LRB- cord-312912-i1yyz5lg 9 45 2 2 CD cord-312912-i1yyz5lg 9 46 ] ] -RRB- cord-312912-i1yyz5lg 9 47 . . . cord-312912-i1yyz5lg 10 1 Since since IN cord-312912-i1yyz5lg 10 2 lithium lithium NN cord-312912-i1yyz5lg 10 3 chloride chloride NN cord-312912-i1yyz5lg 10 4 has have VBZ cord-312912-i1yyz5lg 10 5 been be VBN cord-312912-i1yyz5lg 10 6 demonstrated demonstrate VBN cord-312912-i1yyz5lg 10 7 efficient efficient JJ cord-312912-i1yyz5lg 10 8 in in IN cord-312912-i1yyz5lg 10 9 the the DT cord-312912-i1yyz5lg 10 10 treatment treatment NN cord-312912-i1yyz5lg 10 11 of of IN cord-312912-i1yyz5lg 10 12 human human JJ cord-312912-i1yyz5lg 10 13 herpes herpes NN cord-312912-i1yyz5lg 10 14 simplex simplex NN cord-312912-i1yyz5lg 10 15 virus virus NN cord-312912-i1yyz5lg 10 16 via via IN cord-312912-i1yyz5lg 10 17 its -PRON- PRP$ cord-312912-i1yyz5lg 10 18 role role NN cord-312912-i1yyz5lg 10 19 in in IN cord-312912-i1yyz5lg 10 20 inhibiting inhibit VBG cord-312912-i1yyz5lg 10 21 viral viral JJ cord-312912-i1yyz5lg 10 22 DNA dna NN cord-312912-i1yyz5lg 10 23 synthesis synthesis NN cord-312912-i1yyz5lg 10 24 , , , cord-312912-i1yyz5lg 10 25 it -PRON- PRP cord-312912-i1yyz5lg 10 26 has have VBZ cord-312912-i1yyz5lg 10 27 been be VBN cord-312912-i1yyz5lg 10 28 essayed essay VBN cord-312912-i1yyz5lg 10 29 as as IN cord-312912-i1yyz5lg 10 30 an an DT cord-312912-i1yyz5lg 10 31 antiviral antiviral JJ cord-312912-i1yyz5lg 10 32 agent agent NN cord-312912-i1yyz5lg 10 33 especially especially RB cord-312912-i1yyz5lg 10 34 for for IN cord-312912-i1yyz5lg 10 35 coronaviruses coronaviruse NNS cord-312912-i1yyz5lg 10 36 infections infection NNS cord-312912-i1yyz5lg 10 37 in in IN cord-312912-i1yyz5lg 10 38 many many JJ cord-312912-i1yyz5lg 10 39 studies study NNS cord-312912-i1yyz5lg 10 40 . . . cord-312912-i1yyz5lg 11 1 As as IN cord-312912-i1yyz5lg 11 2 a a DT cord-312912-i1yyz5lg 11 3 matter matter NN cord-312912-i1yyz5lg 11 4 of of IN cord-312912-i1yyz5lg 11 5 fact fact NN cord-312912-i1yyz5lg 11 6 , , , cord-312912-i1yyz5lg 11 7 lithium lithium NN cord-312912-i1yyz5lg 11 8 chloride chloride NN cord-312912-i1yyz5lg 11 9 seems seem VBZ cord-312912-i1yyz5lg 11 10 to to TO cord-312912-i1yyz5lg 11 11 be be VB cord-312912-i1yyz5lg 11 12 a a DT cord-312912-i1yyz5lg 11 13 protective protective JJ cord-312912-i1yyz5lg 11 14 agent agent NN cord-312912-i1yyz5lg 11 15 against against IN cord-312912-i1yyz5lg 11 16 the the DT cord-312912-i1yyz5lg 11 17 infective infective JJ cord-312912-i1yyz5lg 11 18 effect effect NN cord-312912-i1yyz5lg 11 19 of of IN cord-312912-i1yyz5lg 11 20 the the DT cord-312912-i1yyz5lg 11 21 avian avian JJ cord-312912-i1yyz5lg 11 22 coronavirus coronavirus NN cord-312912-i1yyz5lg 11 23 infectious infectious JJ cord-312912-i1yyz5lg 11 24 bronchitis bronchitis NN cord-312912-i1yyz5lg 11 25 virus virus NN cord-312912-i1yyz5lg 11 26 mostly mostly RB cord-312912-i1yyz5lg 11 27 through through IN cord-312912-i1yyz5lg 11 28 an an DT cord-312912-i1yyz5lg 11 29 inhibition inhibition NN cord-312912-i1yyz5lg 11 30 of of IN cord-312912-i1yyz5lg 11 31 viral viral JJ cord-312912-i1yyz5lg 11 32 protein protein NN cord-312912-i1yyz5lg 11 33 production production NN cord-312912-i1yyz5lg 11 34 at at IN cord-312912-i1yyz5lg 11 35 the the DT cord-312912-i1yyz5lg 11 36 level level NN cord-312912-i1yyz5lg 11 37 of of IN cord-312912-i1yyz5lg 11 38 genomic genomic JJ cord-312912-i1yyz5lg 11 39 RNA RNA NNP cord-312912-i1yyz5lg 11 40 and and CC cord-312912-i1yyz5lg 11 41 subgenomic subgenomic NNP cord-312912-i1yyz5lg 11 42 mRNA mRNA NNP cord-312912-i1yyz5lg 11 43 synthesis synthesis NN cord-312912-i1yyz5lg 11 44 without without IN cord-312912-i1yyz5lg 11 45 affecting affect VBG cord-312912-i1yyz5lg 11 46 host host NN cord-312912-i1yyz5lg 11 47 cell cell NN cord-312912-i1yyz5lg 11 48 protein protein NN cord-312912-i1yyz5lg 11 49 production production NN cord-312912-i1yyz5lg 11 50 [ [ -LRB- cord-312912-i1yyz5lg 11 51 3 3 CD cord-312912-i1yyz5lg 11 52 , , , cord-312912-i1yyz5lg 11 53 4 4 CD cord-312912-i1yyz5lg 11 54 ] ] -RRB- cord-312912-i1yyz5lg 11 55 . . . cord-312912-i1yyz5lg 12 1 In in IN cord-312912-i1yyz5lg 12 2 addition addition NN cord-312912-i1yyz5lg 12 3 , , , cord-312912-i1yyz5lg 12 4 lithium lithium NN cord-312912-i1yyz5lg 12 5 chloride chloride NN cord-312912-i1yyz5lg 12 6 has have VBZ cord-312912-i1yyz5lg 12 7 been be VBN cord-312912-i1yyz5lg 12 8 shown show VBN cord-312912-i1yyz5lg 12 9 to to TO cord-312912-i1yyz5lg 12 10 inhibit inhibit VB cord-312912-i1yyz5lg 12 11 the the DT cord-312912-i1yyz5lg 12 12 entry entry NN cord-312912-i1yyz5lg 12 13 and and CC cord-312912-i1yyz5lg 12 14 replication replication NN cord-312912-i1yyz5lg 12 15 of of IN cord-312912-i1yyz5lg 12 16 the the DT cord-312912-i1yyz5lg 12 17 porcine porcine JJ cord-312912-i1yyz5lg 12 18 epidemic epidemic NN cord-312912-i1yyz5lg 12 19 diarrhea diarrhea NN cord-312912-i1yyz5lg 12 20 virus virus NN cord-312912-i1yyz5lg 12 21 into into IN cord-312912-i1yyz5lg 12 22 cells cell NNS cord-312912-i1yyz5lg 12 23 [ [ -LRB- cord-312912-i1yyz5lg 12 24 5 5 CD cord-312912-i1yyz5lg 12 25 ] ] -RRB- cord-312912-i1yyz5lg 12 26 . . . cord-312912-i1yyz5lg 13 1 Rapamycin Rapamycin NNP cord-312912-i1yyz5lg 13 2 and and CC cord-312912-i1yyz5lg 13 3 its -PRON- PRP$ cord-312912-i1yyz5lg 13 4 analogs analog NNS cord-312912-i1yyz5lg 13 5 are be VBP cord-312912-i1yyz5lg 13 6 clinically clinically RB cord-312912-i1yyz5lg 13 7 important important JJ cord-312912-i1yyz5lg 13 8 macrolide macrolide NN cord-312912-i1yyz5lg 13 9 compounds compound NNS cord-312912-i1yyz5lg 13 10 produced produce VBN cord-312912-i1yyz5lg 13 11 by by IN cord-312912-i1yyz5lg 13 12 Streptomyces Streptomyces NNP cord-312912-i1yyz5lg 13 13 hygroscopicus hygroscopicus NNP cord-312912-i1yyz5lg 13 14 . . . cord-312912-i1yyz5lg 14 1 Streptomyces streptomyce NNS cord-312912-i1yyz5lg 14 2 are be VBP cord-312912-i1yyz5lg 14 3 bacteria bacteria NNS cord-312912-i1yyz5lg 14 4 that that WDT cord-312912-i1yyz5lg 14 5 live live VBP cord-312912-i1yyz5lg 14 6 in in IN cord-312912-i1yyz5lg 14 7 symbiosis symbiosis NN cord-312912-i1yyz5lg 14 8 with with IN cord-312912-i1yyz5lg 14 9 plants plant NNS cord-312912-i1yyz5lg 15 1 and and CC cord-312912-i1yyz5lg 15 2 it -PRON- PRP cord-312912-i1yyz5lg 15 3 is be VBZ cord-312912-i1yyz5lg 15 4 expected expect VBN cord-312912-i1yyz5lg 15 5 that that IN cord-312912-i1yyz5lg 15 6 rapamycin rapamycin NN cord-312912-i1yyz5lg 15 7 is be VBZ cord-312912-i1yyz5lg 15 8 one one CD cord-312912-i1yyz5lg 15 9 of of IN cord-312912-i1yyz5lg 15 10 the the DT cord-312912-i1yyz5lg 15 11 products product NNS cord-312912-i1yyz5lg 15 12 that that WDT cord-312912-i1yyz5lg 15 13 helps help VBZ cord-312912-i1yyz5lg 15 14 the the DT cord-312912-i1yyz5lg 15 15 plants plant NNS cord-312912-i1yyz5lg 15 16 fight fight VB cord-312912-i1yyz5lg 15 17 against against IN cord-312912-i1yyz5lg 15 18 pathogens pathogen NNS cord-312912-i1yyz5lg 15 19 such such JJ cord-312912-i1yyz5lg 15 20 as as IN cord-312912-i1yyz5lg 15 21 other other JJ cord-312912-i1yyz5lg 15 22 bacteria bacteria NNS cord-312912-i1yyz5lg 15 23 , , , cord-312912-i1yyz5lg 15 24 fungi fungus NNS cord-312912-i1yyz5lg 15 25 and and CC cord-312912-i1yyz5lg 15 26 viruses virus NNS cord-312912-i1yyz5lg 15 27 [ [ -LRB- cord-312912-i1yyz5lg 15 28 6 6 CD cord-312912-i1yyz5lg 15 29 ] ] -RRB- cord-312912-i1yyz5lg 15 30 . . . cord-312912-i1yyz5lg 16 1 The the DT cord-312912-i1yyz5lg 16 2 mammalian mammalian JJ cord-312912-i1yyz5lg 16 3 target target NN cord-312912-i1yyz5lg 16 4 of of IN cord-312912-i1yyz5lg 16 5 rapamycin rapamycin NNP cord-312912-i1yyz5lg 16 6 ( ( -LRB- cord-312912-i1yyz5lg 16 7 mTOR mTOR NNP cord-312912-i1yyz5lg 16 8 ) ) -RRB- cord-312912-i1yyz5lg 16 9 is be VBZ cord-312912-i1yyz5lg 16 10 a a DT cord-312912-i1yyz5lg 16 11 serine serine NN cord-312912-i1yyz5lg 16 12 / / SYM cord-312912-i1yyz5lg 16 13 threonine threonine NN cord-312912-i1yyz5lg 16 14 kinase kinase NN cord-312912-i1yyz5lg 16 15 that that WDT cord-312912-i1yyz5lg 16 16 functions function VBZ cord-312912-i1yyz5lg 16 17 as as IN cord-312912-i1yyz5lg 16 18 a a DT cord-312912-i1yyz5lg 16 19 central central JJ cord-312912-i1yyz5lg 16 20 regulator regulator NN cord-312912-i1yyz5lg 16 21 of of IN cord-312912-i1yyz5lg 16 22 cell cell NN cord-312912-i1yyz5lg 16 23 growth growth NN cord-312912-i1yyz5lg 16 24 and and CC cord-312912-i1yyz5lg 16 25 metabolism metabolism NN cord-312912-i1yyz5lg 16 26 . . . cord-312912-i1yyz5lg 17 1 Rapamycin Rapamycin NNP cord-312912-i1yyz5lg 17 2 and and CC cord-312912-i1yyz5lg 17 3 its -PRON- PRP$ cord-312912-i1yyz5lg 17 4 analogs analog NNS cord-312912-i1yyz5lg 17 5 are be VBP cord-312912-i1yyz5lg 17 6 specific specific JJ cord-312912-i1yyz5lg 17 7 inhibitors inhibitor NNS cord-312912-i1yyz5lg 17 8 of of IN cord-312912-i1yyz5lg 17 9 mTOR mTOR NNP cord-312912-i1yyz5lg 17 10 kinase kinase NN cord-312912-i1yyz5lg 17 11 and and CC cord-312912-i1yyz5lg 17 12 , , , cord-312912-i1yyz5lg 17 13 as as IN cord-312912-i1yyz5lg 17 14 a a DT cord-312912-i1yyz5lg 17 15 result result NN cord-312912-i1yyz5lg 17 16 , , , cord-312912-i1yyz5lg 17 17 are be VBP cord-312912-i1yyz5lg 17 18 wellestablished wellestablishe VBN cord-312912-i1yyz5lg 17 19 immunosuppressants immunosuppressant NNS cord-312912-i1yyz5lg 17 20 and and CC cord-312912-i1yyz5lg 17 21 antitumorigenic antitumorigenic JJ cord-312912-i1yyz5lg 17 22 agents agent NNS cord-312912-i1yyz5lg 17 23 that that WDT cord-312912-i1yyz5lg 17 24 play play VBP cord-312912-i1yyz5lg 17 25 a a DT cord-312912-i1yyz5lg 17 26 role role NN cord-312912-i1yyz5lg 17 27 in in IN cord-312912-i1yyz5lg 17 28 cell cell NN cord-312912-i1yyz5lg 17 29 proliferation proliferation NN cord-312912-i1yyz5lg 17 30 and and CC cord-312912-i1yyz5lg 17 31 survival survival NN cord-312912-i1yyz5lg 17 32 as as RB cord-312912-i1yyz5lg 17 33 well well RB cord-312912-i1yyz5lg 17 34 as as IN cord-312912-i1yyz5lg 17 35 macroautophagy macroautophagy NN cord-312912-i1yyz5lg 17 36 suppression suppression NN cord-312912-i1yyz5lg 17 37 [ [ -LRB- cord-312912-i1yyz5lg 17 38 7 7 CD cord-312912-i1yyz5lg 17 39 ] ] -RRB- cord-312912-i1yyz5lg 17 40 . . . cord-312912-i1yyz5lg 18 1 When when WRB cord-312912-i1yyz5lg 18 2 rapamycin rapamycin NN cord-312912-i1yyz5lg 18 3 forms form VBZ cord-312912-i1yyz5lg 18 4 a a DT cord-312912-i1yyz5lg 18 5 complex complex NN cord-312912-i1yyz5lg 18 6 with with IN cord-312912-i1yyz5lg 18 7 its -PRON- PRP$ cord-312912-i1yyz5lg 18 8 receptor receptor NN cord-312912-i1yyz5lg 18 9 and and CC cord-312912-i1yyz5lg 18 10 interacts interact VBZ cord-312912-i1yyz5lg 18 11 with with IN cord-312912-i1yyz5lg 18 12 mTOR mTOR NNP cord-312912-i1yyz5lg 18 13 , , , cord-312912-i1yyz5lg 18 14 this this DT cord-312912-i1yyz5lg 18 15 blocks block VBZ cord-312912-i1yyz5lg 18 16 the the DT cord-312912-i1yyz5lg 18 17 cell cell NN cord-312912-i1yyz5lg 18 18 - - HYPH cord-312912-i1yyz5lg 18 19 cycle cycle NN cord-312912-i1yyz5lg 18 20 progression progression NN cord-312912-i1yyz5lg 18 21 of of IN cord-312912-i1yyz5lg 18 22 T t NN cord-312912-i1yyz5lg 18 23 cells cell NNS cord-312912-i1yyz5lg 18 24 thereby thereby RB cord-312912-i1yyz5lg 18 25 suppressing suppress VBG cord-312912-i1yyz5lg 18 26 their -PRON- PRP$ cord-312912-i1yyz5lg 18 27 induced induce VBN cord-312912-i1yyz5lg 18 28 proliferation proliferation NN cord-312912-i1yyz5lg 18 29 by by IN cord-312912-i1yyz5lg 18 30 cross cross NN cord-312912-i1yyz5lg 18 31 - - NN cord-312912-i1yyz5lg 18 32 linking linking NN cord-312912-i1yyz5lg 18 33 of of IN cord-312912-i1yyz5lg 18 34 the the DT cord-312912-i1yyz5lg 18 35 T t NN cord-312912-i1yyz5lg 18 36 - - HYPH cord-312912-i1yyz5lg 18 37 cell cell NN cord-312912-i1yyz5lg 18 38 receptors receptor NNS cord-312912-i1yyz5lg 18 39 , , , cord-312912-i1yyz5lg 18 40 antigenic antigenic JJ cord-312912-i1yyz5lg 18 41 peptides peptide NNS cord-312912-i1yyz5lg 18 42 or or CC cord-312912-i1yyz5lg 18 43 cytokines cytokine NNS cord-312912-i1yyz5lg 18 44 such such JJ cord-312912-i1yyz5lg 18 45 as as IN cord-312912-i1yyz5lg 18 46 inteleukin-2 inteleukin-2 NNP cord-312912-i1yyz5lg 18 47 ( ( -LRB- cord-312912-i1yyz5lg 18 48 IL-2 IL-2 NNP cord-312912-i1yyz5lg 18 49 ) ) -RRB- cord-312912-i1yyz5lg 18 50 [ [ -LRB- cord-312912-i1yyz5lg 18 51 8 8 CD cord-312912-i1yyz5lg 18 52 ] ] -RRB- cord-312912-i1yyz5lg 18 53 . . . cord-312912-i1yyz5lg 19 1 On on IN cord-312912-i1yyz5lg 19 2 another another DT cord-312912-i1yyz5lg 19 3 level level NN cord-312912-i1yyz5lg 19 4 , , , cord-312912-i1yyz5lg 19 5 mTOR mtor NN cord-312912-i1yyz5lg 19 6 complex complex NN cord-312912-i1yyz5lg 19 7 and and CC cord-312912-i1yyz5lg 19 8 glycogen glycogen JJ cord-312912-i1yyz5lg 19 9 synthase synthase NN cord-312912-i1yyz5lg 19 10 kinase kinase NN cord-312912-i1yyz5lg 19 11 3β 3β CD cord-312912-i1yyz5lg 19 12 have have VBP cord-312912-i1yyz5lg 19 13 a a DT cord-312912-i1yyz5lg 19 14 direct direct JJ cord-312912-i1yyz5lg 19 15 mutual mutual JJ cord-312912-i1yyz5lg 19 16 influence influence NN cord-312912-i1yyz5lg 19 17 in in IN cord-312912-i1yyz5lg 19 18 order order NN cord-312912-i1yyz5lg 19 19 to to TO cord-312912-i1yyz5lg 19 20 regulate regulate VB cord-312912-i1yyz5lg 19 21 the the DT cord-312912-i1yyz5lg 19 22 immune immune JJ cord-312912-i1yyz5lg 19 23 response response NN cord-312912-i1yyz5lg 19 24 since since IN cord-312912-i1yyz5lg 19 25 mTOR mTOR NNP cord-312912-i1yyz5lg 19 26 complex complex NNP cord-312912-i1yyz5lg 19 27 inhibition inhibition NN cord-312912-i1yyz5lg 19 28 regulates regulate VBZ cord-312912-i1yyz5lg 19 29 pro pro JJ cord-312912-i1yyz5lg 19 30 - - JJ cord-312912-i1yyz5lg 19 31 and and CC cord-312912-i1yyz5lg 19 32 antiinflammatory antiinflammatory JJ cord-312912-i1yyz5lg 19 33 cytokine cytokine NN cord-312912-i1yyz5lg 19 34 production production NN cord-312912-i1yyz5lg 19 35 via via IN cord-312912-i1yyz5lg 19 36 its -PRON- PRP$ cord-312912-i1yyz5lg 19 37 capacity capacity NN cord-312912-i1yyz5lg 19 38 to to TO cord-312912-i1yyz5lg 19 39 inactivate inactivate VB cord-312912-i1yyz5lg 19 40 glycogen glycogen NN cord-312912-i1yyz5lg 19 41 synthase synthase NN cord-312912-i1yyz5lg 19 42 kinase kinase NN cord-312912-i1yyz5lg 19 43 3β 3β CD cord-312912-i1yyz5lg 19 44 [ [ -LRB- cord-312912-i1yyz5lg 19 45 9 9 CD cord-312912-i1yyz5lg 19 46 ] ] -RRB- cord-312912-i1yyz5lg 19 47 . . . cord-312912-i1yyz5lg 20 1 In in IN cord-312912-i1yyz5lg 20 2 the the DT cord-312912-i1yyz5lg 20 3 transmissible transmissible JJ cord-312912-i1yyz5lg 20 4 gastroenteritis gastroenteritis NN cord-312912-i1yyz5lg 20 5 virus virus NN cord-312912-i1yyz5lg 20 6 , , , cord-312912-i1yyz5lg 20 7 autophagy autophagy NN cord-312912-i1yyz5lg 20 8 seems seem VBZ cord-312912-i1yyz5lg 20 9 to to TO cord-312912-i1yyz5lg 20 10 play play VB cord-312912-i1yyz5lg 20 11 an an DT cord-312912-i1yyz5lg 20 12 important important JJ cord-312912-i1yyz5lg 20 13 role role NN cord-312912-i1yyz5lg 20 14 in in IN cord-312912-i1yyz5lg 20 15 this this DT cord-312912-i1yyz5lg 20 16 coronavirus coronavirus NN cord-312912-i1yyz5lg 20 17 infection infection NN cord-312912-i1yyz5lg 20 18 . . . cord-312912-i1yyz5lg 21 1 Treatment treatment NN cord-312912-i1yyz5lg 21 2 with with IN cord-312912-i1yyz5lg 21 3 rapamycin rapamycin NN cord-312912-i1yyz5lg 21 4 seems seem VBZ cord-312912-i1yyz5lg 21 5 to to TO cord-312912-i1yyz5lg 21 6 induce induce VB cord-312912-i1yyz5lg 21 7 autophagy autophagy NN cord-312912-i1yyz5lg 21 8 and and CC cord-312912-i1yyz5lg 21 9 to to TO cord-312912-i1yyz5lg 21 10 protect protect VB cord-312912-i1yyz5lg 21 11 cells cell NNS cord-312912-i1yyz5lg 21 12 against against IN cord-312912-i1yyz5lg 21 13 viral viral JJ cord-312912-i1yyz5lg 21 14 replication replication NN cord-312912-i1yyz5lg 21 15 [ [ -LRB- cord-312912-i1yyz5lg 21 16 10 10 CD cord-312912-i1yyz5lg 21 17 ] ] -RRB- cord-312912-i1yyz5lg 21 18 . . . cord-312912-i1yyz5lg 22 1 Patients patient NNS cord-312912-i1yyz5lg 22 2 with with IN cord-312912-i1yyz5lg 22 3 the the DT cord-312912-i1yyz5lg 22 4 most most RBS cord-312912-i1yyz5lg 22 5 important important JJ cord-312912-i1yyz5lg 22 6 lung lung NN cord-312912-i1yyz5lg 22 7 injury injury NN cord-312912-i1yyz5lg 22 8 related relate VBN cord-312912-i1yyz5lg 22 9 to to IN cord-312912-i1yyz5lg 22 10 COVID-19 COVID-19 NNP cord-312912-i1yyz5lg 22 11 are be VBP cord-312912-i1yyz5lg 22 12 those those DT cord-312912-i1yyz5lg 22 13 who who WP cord-312912-i1yyz5lg 22 14 have have VBP cord-312912-i1yyz5lg 22 15 a a DT cord-312912-i1yyz5lg 22 16 dysregulated dysregulated JJ cord-312912-i1yyz5lg 22 17 response response NN cord-312912-i1yyz5lg 22 18 for for IN cord-312912-i1yyz5lg 22 19 the the DT cord-312912-i1yyz5lg 22 20 viral viral JJ cord-312912-i1yyz5lg 22 21 infection infection NN cord-312912-i1yyz5lg 22 22 predominating predominate VBG cord-312912-i1yyz5lg 22 23 in in IN cord-312912-i1yyz5lg 22 24 T T NNP cord-312912-i1yyz5lg 22 25 cells cell NNS cord-312912-i1yyz5lg 22 26 function function VBP cord-312912-i1yyz5lg 22 27 [ [ -LRB- cord-312912-i1yyz5lg 22 28 11 11 CD cord-312912-i1yyz5lg 22 29 ] ] -RRB- cord-312912-i1yyz5lg 22 30 . . . cord-312912-i1yyz5lg 23 1 It -PRON- PRP cord-312912-i1yyz5lg 23 2 might may MD cord-312912-i1yyz5lg 23 3 be be VB cord-312912-i1yyz5lg 23 4 hypothesized hypothesize VBN cord-312912-i1yyz5lg 23 5 that that IN cord-312912-i1yyz5lg 23 6 COVID-19 COVID-19 NNP cord-312912-i1yyz5lg 23 7 may may MD cord-312912-i1yyz5lg 23 8 delay delay VB cord-312912-i1yyz5lg 23 9 the the DT cord-312912-i1yyz5lg 23 10 interferon interferon NN cord-312912-i1yyz5lg 23 11 response response NN cord-312912-i1yyz5lg 23 12 until until IN cord-312912-i1yyz5lg 23 13 the the DT cord-312912-i1yyz5lg 23 14 virus virus NN cord-312912-i1yyz5lg 23 15 has have VBZ cord-312912-i1yyz5lg 23 16 sufficiently sufficiently RB cord-312912-i1yyz5lg 23 17 replicated replicate VBN cord-312912-i1yyz5lg 23 18 which which WDT cord-312912-i1yyz5lg 23 19 causes cause VBZ cord-312912-i1yyz5lg 23 20 a a DT cord-312912-i1yyz5lg 23 21 sensitization sensitization NN cord-312912-i1yyz5lg 23 22 of of IN cord-312912-i1yyz5lg 23 23 T t NN cord-312912-i1yyz5lg 23 24 cells cell NNS cord-312912-i1yyz5lg 23 25 towards towards IN cord-312912-i1yyz5lg 23 26 apoptosis apoptosis NN cord-312912-i1yyz5lg 23 27 and and CC cord-312912-i1yyz5lg 23 28 macrophage macrophage NN cord-312912-i1yyz5lg 23 29 stimulation stimulation NN cord-312912-i1yyz5lg 23 30 . . . cord-312912-i1yyz5lg 24 1 Patients patient NNS cord-312912-i1yyz5lg 24 2 with with IN cord-312912-i1yyz5lg 24 3 the the DT cord-312912-i1yyz5lg 24 4 highest high JJS cord-312912-i1yyz5lg 24 5 threshold threshold NN cord-312912-i1yyz5lg 24 6 for for IN cord-312912-i1yyz5lg 24 7 interferon interferon NN cord-312912-i1yyz5lg 24 8 - - HYPH cord-312912-i1yyz5lg 24 9 response response NN cord-312912-i1yyz5lg 24 10 such such JJ cord-312912-i1yyz5lg 24 11 as as IN cord-312912-i1yyz5lg 24 12 the the DT cord-312912-i1yyz5lg 24 13 elderly elderly JJ cord-312912-i1yyz5lg 24 14 seem seem VBP cord-312912-i1yyz5lg 24 15 to to TO cord-312912-i1yyz5lg 24 16 be be VB cord-312912-i1yyz5lg 24 17 most most RBS cord-312912-i1yyz5lg 24 18 affected affect VBN cord-312912-i1yyz5lg 24 19 by by IN cord-312912-i1yyz5lg 24 20 COVID-19 COVID-19 NNP cord-312912-i1yyz5lg 24 21 pneumonia pneumonia NN cord-312912-i1yyz5lg 24 22 . . . cord-312912-i1yyz5lg 25 1 The the DT cord-312912-i1yyz5lg 25 2 rationale rationale NN cord-312912-i1yyz5lg 25 3 of of IN cord-312912-i1yyz5lg 25 4 combining combine VBG cord-312912-i1yyz5lg 25 5 lithium lithium NN cord-312912-i1yyz5lg 25 6 chloride chloride NN cord-312912-i1yyz5lg 25 7 and and CC cord-312912-i1yyz5lg 25 8 rapamycin rapamycin NN cord-312912-i1yyz5lg 25 9 consists consist VBZ cord-312912-i1yyz5lg 25 10 on on IN cord-312912-i1yyz5lg 25 11 reducing reduce VBG cord-312912-i1yyz5lg 25 12 the the DT cord-312912-i1yyz5lg 25 13 possibility possibility NN cord-312912-i1yyz5lg 25 14 of of IN cord-312912-i1yyz5lg 25 15 viral viral JJ cord-312912-i1yyz5lg 25 16 replication replication NN cord-312912-i1yyz5lg 25 17 at at IN cord-312912-i1yyz5lg 25 18 its -PRON- PRP$ cord-312912-i1yyz5lg 25 19 lowest low JJS cord-312912-i1yyz5lg 25 20 by by IN cord-312912-i1yyz5lg 25 21 reducing reduce VBG cord-312912-i1yyz5lg 25 22 viral viral JJ cord-312912-i1yyz5lg 25 23 entry entry NN cord-312912-i1yyz5lg 25 24 to to IN cord-312912-i1yyz5lg 25 25 cells cell NNS cord-312912-i1yyz5lg 25 26 and and CC cord-312912-i1yyz5lg 25 27 viral viral JJ cord-312912-i1yyz5lg 25 28 RNA RNA NNP cord-312912-i1yyz5lg 25 29 synthesis synthesis NN cord-312912-i1yyz5lg 25 30 ( ( -LRB- cord-312912-i1yyz5lg 25 31 the the DT cord-312912-i1yyz5lg 25 32 effect effect NN cord-312912-i1yyz5lg 25 33 of of IN cord-312912-i1yyz5lg 25 34 lithium lithium NN cord-312912-i1yyz5lg 25 35 due due IN cord-312912-i1yyz5lg 25 36 to to IN cord-312912-i1yyz5lg 25 37 protein protein NN cord-312912-i1yyz5lg 25 38 synthesis synthesis NN cord-312912-i1yyz5lg 25 39 inhibition inhibition NN cord-312912-i1yyz5lg 25 40 via via IN cord-312912-i1yyz5lg 25 41 glycogen glycogen NN cord-312912-i1yyz5lg 25 42 synthase synthase NN cord-312912-i1yyz5lg 25 43 kinase kinase VBD cord-312912-i1yyz5lg 25 44 3β 3β CD cord-312912-i1yyz5lg 25 45 deactivation deactivation NN cord-312912-i1yyz5lg 25 46 ) ) -RRB- cord-312912-i1yyz5lg 25 47 from from IN cord-312912-i1yyz5lg 25 48 one one CD cord-312912-i1yyz5lg 25 49 part part NN cord-312912-i1yyz5lg 25 50 , , , cord-312912-i1yyz5lg 25 51 and and CC cord-312912-i1yyz5lg 25 52 regulating regulate VBG cord-312912-i1yyz5lg 25 53 the the DT cord-312912-i1yyz5lg 25 54 immune immune JJ cord-312912-i1yyz5lg 25 55 response response NN cord-312912-i1yyz5lg 25 56 and and CC cord-312912-i1yyz5lg 25 57 stimulating stimulate VBG cord-312912-i1yyz5lg 25 58 autophagy autophagy NN cord-312912-i1yyz5lg 25 59 without without IN cord-312912-i1yyz5lg 25 60 apoptosis apoptosis NN cord-312912-i1yyz5lg 25 61 from from IN cord-312912-i1yyz5lg 25 62 another another DT cord-312912-i1yyz5lg 25 63 part part NN cord-312912-i1yyz5lg 25 64 ( ( -LRB- cord-312912-i1yyz5lg 25 65 the the DT cord-312912-i1yyz5lg 25 66 effect effect NN cord-312912-i1yyz5lg 25 67 of of IN cord-312912-i1yyz5lg 25 68 rapamycin rapamycin NNP cord-312912-i1yyz5lg 25 69 via via IN cord-312912-i1yyz5lg 25 70 mTOR mTOR NNP cord-312912-i1yyz5lg 25 71 inhibition inhibition NN cord-312912-i1yyz5lg 25 72 and and CC cord-312912-i1yyz5lg 25 73 T T NNP cord-312912-i1yyz5lg 25 74 cell cell NN cord-312912-i1yyz5lg 25 75 regulation regulation NN cord-312912-i1yyz5lg 25 76 ) ) -RRB- cord-312912-i1yyz5lg 25 77 . . . cord-312912-i1yyz5lg 26 1 Clinical clinical JJ cord-312912-i1yyz5lg 26 2 studies study NNS cord-312912-i1yyz5lg 26 3 are be VBP cord-312912-i1yyz5lg 26 4 further further RB cord-312912-i1yyz5lg 26 5 needed need VBN cord-312912-i1yyz5lg 26 6 in in IN cord-312912-i1yyz5lg 26 7 this this DT cord-312912-i1yyz5lg 26 8 domain domain NN cord-312912-i1yyz5lg 26 9 . . . cord-312912-i1yyz5lg 27 1 the the DT cord-312912-i1yyz5lg 27 2 - - HYPH cord-312912-i1yyz5lg 27 3 media media NN cord-312912-i1yyz5lg 27 4 - - HYPH cord-312912-i1yyz5lg 27 5 briefing briefing NN cord-312912-i1yyz5lg 27 6 - - HYPH cord-312912-i1yyz5lg 27 7 on on IN cord-312912-i1yyz5lg 27 8 - - HYPH cord-312912-i1yyz5lg 27 9 covid covid NNP cord-312912-i1yyz5lg 27 10 Oldie Oldie NNP cord-312912-i1yyz5lg 27 11 but but CC cord-312912-i1yyz5lg 27 12 Goodie Goodie NNP cord-312912-i1yyz5lg 27 13 : : : cord-312912-i1yyz5lg 27 14 lithium lithium NN cord-312912-i1yyz5lg 27 15 in in IN cord-312912-i1yyz5lg 27 16 the the DT cord-312912-i1yyz5lg 27 17 treatment treatment NN cord-312912-i1yyz5lg 27 18 of of IN cord-312912-i1yyz5lg 27 19 bipolar bipolar JJ cord-312912-i1yyz5lg 27 20 disorder disorder NN cord-312912-i1yyz5lg 27 21 through through IN cord-312912-i1yyz5lg 27 22 neuroprotective neuroprotective JJ cord-312912-i1yyz5lg 27 23 and and CC cord-312912-i1yyz5lg 27 24 neurotrophic neurotrophic NN cord-312912-i1yyz5lg 27 25 mechanisms mechanism NNS cord-312912-i1yyz5lg 27 26 Lithium Lithium NNP cord-312912-i1yyz5lg 27 27 chloride chloride NN cord-312912-i1yyz5lg 27 28 inhibits inhibit VBZ cord-312912-i1yyz5lg 27 29 the the DT cord-312912-i1yyz5lg 27 30 coronavirus coronavirus NN cord-312912-i1yyz5lg 27 31 infectious infectious JJ cord-312912-i1yyz5lg 27 32 bronchitis bronchitis NN cord-312912-i1yyz5lg 27 33 virus virus NN cord-312912-i1yyz5lg 27 34 in in IN cord-312912-i1yyz5lg 27 35 cell cell NN cord-312912-i1yyz5lg 27 36 culture culture NN cord-312912-i1yyz5lg 28 1 Comparative comparative JJ cord-312912-i1yyz5lg 28 2 analysis analysis NN cord-312912-i1yyz5lg 28 3 of of IN cord-312912-i1yyz5lg 28 4 the the DT cord-312912-i1yyz5lg 28 5 effect effect NN cord-312912-i1yyz5lg 28 6 of of IN cord-312912-i1yyz5lg 28 7 glycyrrhizin glycyrrhizin NNP cord-312912-i1yyz5lg 28 8 diammonium diammonium NN cord-312912-i1yyz5lg 28 9 and and CC cord-312912-i1yyz5lg 28 10 lithium lithium NN cord-312912-i1yyz5lg 28 11 chloride chloride NN cord-312912-i1yyz5lg 28 12 on on IN cord-312912-i1yyz5lg 28 13 infectious infectious JJ cord-312912-i1yyz5lg 28 14 bronchitis bronchitis NN cord-312912-i1yyz5lg 28 15 virus virus NN cord-312912-i1yyz5lg 28 16 infection infection NN cord-312912-i1yyz5lg 28 17 in in IN cord-312912-i1yyz5lg 28 18 vitro vitro FW cord-312912-i1yyz5lg 28 19 Antiviral antiviral JJ cord-312912-i1yyz5lg 28 20 effect effect NN cord-312912-i1yyz5lg 28 21 of of IN cord-312912-i1yyz5lg 28 22 lithium lithium NN cord-312912-i1yyz5lg 28 23 chloride chloride NN cord-312912-i1yyz5lg 28 24 on on IN cord-312912-i1yyz5lg 28 25 porcine porcine JJ cord-312912-i1yyz5lg 28 26 epidemic epidemic NN cord-312912-i1yyz5lg 28 27 diarrhea diarrhea NN cord-312912-i1yyz5lg 28 28 virus virus NN cord-312912-i1yyz5lg 28 29 in in IN cord-312912-i1yyz5lg 28 30 vitro vitro FW cord-312912-i1yyz5lg 28 31 Antibiotics antibiotic NNS cord-312912-i1yyz5lg 28 32 produced produce VBN cord-312912-i1yyz5lg 28 33 by by IN cord-312912-i1yyz5lg 28 34 streptomyces streptomyces NNP cord-312912-i1yyz5lg 28 35 mTOR mTOR NNP cord-312912-i1yyz5lg 28 36 inhibitors inhibitor NNS cord-312912-i1yyz5lg 28 37 lower lower VBP cord-312912-i1yyz5lg 28 38 an an DT cord-312912-i1yyz5lg 28 39 intrinsic intrinsic JJ cord-312912-i1yyz5lg 28 40 barrier barrier NN cord-312912-i1yyz5lg 28 41 to to IN cord-312912-i1yyz5lg 28 42 virus virus NN cord-312912-i1yyz5lg 28 43 infection infection NN cord-312912-i1yyz5lg 28 44 mediated mediate VBN cord-312912-i1yyz5lg 28 45 by by IN cord-312912-i1yyz5lg 28 46 IFITM3 IFITM3 NNP cord-312912-i1yyz5lg 28 47 Biosynthesis Biosynthesis NNP cord-312912-i1yyz5lg 28 48 of of IN cord-312912-i1yyz5lg 28 49 rapamycin rapamycin NN cord-312912-i1yyz5lg 28 50 and and CC cord-312912-i1yyz5lg 28 51 its -PRON- PRP$ cord-312912-i1yyz5lg 28 52 regulation regulation NN cord-312912-i1yyz5lg 28 53 : : : cord-312912-i1yyz5lg 28 54 past past JJ cord-312912-i1yyz5lg 28 55 achievements achievement NNS cord-312912-i1yyz5lg 28 56 and and CC cord-312912-i1yyz5lg 28 57 recent recent JJ cord-312912-i1yyz5lg 28 58 progress progress NN cord-312912-i1yyz5lg 28 59 Convergence Convergence NNP cord-312912-i1yyz5lg 28 60 of of IN cord-312912-i1yyz5lg 28 61 the the DT cord-312912-i1yyz5lg 28 62 mammalian mammalian JJ cord-312912-i1yyz5lg 28 63 target target NN cord-312912-i1yyz5lg 28 64 of of IN cord-312912-i1yyz5lg 28 65 rapamycin rapamycin NN cord-312912-i1yyz5lg 28 66 complex complex JJ cord-312912-i1yyz5lg 28 67 1-and 1-and CD cord-312912-i1yyz5lg 28 68 glycogen glycogen NN cord-312912-i1yyz5lg 28 69 synthase synthase NN cord-312912-i1yyz5lg 28 70 kinase kinase VBD cord-312912-i1yyz5lg 28 71 3-β 3-β CD cord-312912-i1yyz5lg 28 72 - - HYPH cord-312912-i1yyz5lg 28 73 signaling signal VBG cord-312912-i1yyz5lg 28 74 pathways pathway NNS cord-312912-i1yyz5lg 28 75 regulates regulate VBZ cord-312912-i1yyz5lg 28 76 the the DT cord-312912-i1yyz5lg 28 77 innate innate JJ cord-312912-i1yyz5lg 28 78 inflammatory inflammatory JJ cord-312912-i1yyz5lg 28 79 response response NN cord-312912-i1yyz5lg 28 80 Autophagy Autophagy NNP cord-312912-i1yyz5lg 28 81 negatively negatively RB cord-312912-i1yyz5lg 28 82 regulates regulate VBZ cord-312912-i1yyz5lg 28 83 transmissible transmissible JJ cord-312912-i1yyz5lg 28 84 gastroenteritis gastroenteritis NN cord-312912-i1yyz5lg 28 85 virus virus NN cord-312912-i1yyz5lg 28 86 replication replication NN cord-312912-i1yyz5lg 28 87 Dysregulation Dysregulation NNP cord-312912-i1yyz5lg 28 88 of of IN cord-312912-i1yyz5lg 28 89 immune immune JJ cord-312912-i1yyz5lg 28 90 response response NN cord-312912-i1yyz5lg 28 91 in in IN cord-312912-i1yyz5lg 28 92 patients patient NNS cord-312912-i1yyz5lg 28 93 with with IN cord-312912-i1yyz5lg 28 94 COVID-19 COVID-19 NNP cord-312912-i1yyz5lg 28 95 in in IN cord-312912-i1yyz5lg 28 96 Wuhan Wuhan NNP cord-312912-i1yyz5lg 28 97 , , , cord-312912-i1yyz5lg 28 98 China China NNP