id	sid	tid	token	lemma	pos
cord-297178-moxhk2e0	1	1	key	key	JJ
cord-297178-moxhk2e0	2	1	:	:	:
cord-297178-moxhk2e0	2	2	cord-297178-moxhk2e0	cord-297178-moxhk2e0	NNP
cord-297178-moxhk2e0	2	3	authors	author	NNS
cord-297178-moxhk2e0	2	4	:	:	:
cord-297178-moxhk2e0	2	5	Novaes	Novaes	NNP
cord-297178-moxhk2e0	2	6	Rocha	Rocha	NNP
cord-297178-moxhk2e0	2	7	,	,	,
cord-297178-moxhk2e0	2	8	Vinicius	Vinicius	NNP
cord-297178-moxhk2e0	2	9	title	title	NN
cord-297178-moxhk2e0	2	10	:	:	:
cord-297178-moxhk2e0	2	11	Viral	viral	JJ
cord-297178-moxhk2e0	2	12	replication	replication	NN
cord-297178-moxhk2e0	2	13	of	of	IN
cord-297178-moxhk2e0	2	14	SARS	SARS	NNP
cord-297178-moxhk2e0	2	15	-	-	HYPH
cord-297178-moxhk2e0	2	16	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	2	17	could	could	MD
cord-297178-moxhk2e0	2	18	be	be	VB
cord-297178-moxhk2e0	2	19	self	self	NN
cord-297178-moxhk2e0	2	20	-	-	HYPH
cord-297178-moxhk2e0	2	21	limitative	limitative	RB
cord-297178-moxhk2e0	2	22	-	-	:
cord-297178-moxhk2e0	2	23	the	the	DT
cord-297178-moxhk2e0	2	24	role	role	NN
cord-297178-moxhk2e0	2	25	of	of	IN
cord-297178-moxhk2e0	2	26	the	the	DT
cord-297178-moxhk2e0	2	27	renin	renin	NN
cord-297178-moxhk2e0	2	28	-	-	HYPH
cord-297178-moxhk2e0	2	29	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	2	30	system	system	NN
cord-297178-moxhk2e0	2	31	on	on	IN
cord-297178-moxhk2e0	2	32	COVID-19	covid-19	JJ
cord-297178-moxhk2e0	2	33	pathophysiology	pathophysiology	NN
cord-297178-moxhk2e0	2	34	date	date	NN
cord-297178-moxhk2e0	2	35	:	:	:
cord-297178-moxhk2e0	2	36	2020	2020	CD
cord-297178-moxhk2e0	2	37	-	-	SYM
cord-297178-moxhk2e0	2	38	10	10	CD
cord-297178-moxhk2e0	2	39	-	-	HYPH
cord-297178-moxhk2e0	2	40	01	01	CD
cord-297178-moxhk2e0	2	41	journal	journal	NN
cord-297178-moxhk2e0	2	42	:	:	:
cord-297178-moxhk2e0	3	1	Med	Med	NNP
cord-297178-moxhk2e0	3	2	Hypotheses	Hypotheses	NNP
cord-297178-moxhk2e0	3	3	DOI	DOI	NNP
cord-297178-moxhk2e0	3	4	:	:	:
cord-297178-moxhk2e0	3	5	10.1016	10.1016	CD
cord-297178-moxhk2e0	3	6	/	/	SYM
cord-297178-moxhk2e0	3	7	j.mehy.2020.110330	j.mehy.2020.110330	VBD
cord-297178-moxhk2e0	3	8	sha	sha	NNP
cord-297178-moxhk2e0	3	9	:	:	:
cord-297178-moxhk2e0	3	10	c673287500ff7b36bc41594fb0fdd990db356679	c673287500ff7b36bc41594fb0fdd990db356679	NNP
cord-297178-moxhk2e0	3	11	doc_id	doc_id	NNP
cord-297178-moxhk2e0	3	12	:	:	:
cord-297178-moxhk2e0	3	13	297178	297178	CD
cord-297178-moxhk2e0	3	14	cord_uid	cord_uid	NNS
cord-297178-moxhk2e0	3	15	:	:	:
cord-297178-moxhk2e0	4	1	moxhk2e0	moxhk2e0	NNP
cord-297178-moxhk2e0	4	2	Currently	currently	RB
cord-297178-moxhk2e0	4	3	,	,	,
cord-297178-moxhk2e0	4	4	the	the	DT
cord-297178-moxhk2e0	4	5	world	world	NN
cord-297178-moxhk2e0	4	6	is	be	VBZ
cord-297178-moxhk2e0	4	7	suffering	suffer	VBG
cord-297178-moxhk2e0	4	8	with	with	IN
cord-297178-moxhk2e0	4	9	one	one	CD
cord-297178-moxhk2e0	4	10	of	of	IN
cord-297178-moxhk2e0	4	11	the	the	DT
cord-297178-moxhk2e0	4	12	biggest	big	JJS
cord-297178-moxhk2e0	4	13	pandemics	pandemic	NNS
cord-297178-moxhk2e0	4	14	of	of	IN
cord-297178-moxhk2e0	4	15	recent	recent	JJ
cord-297178-moxhk2e0	4	16	history	history	NN
cord-297178-moxhk2e0	4	17	.	.	.
cord-297178-moxhk2e0	5	1	Caused	cause	VBN
cord-297178-moxhk2e0	5	2	by	by	IN
cord-297178-moxhk2e0	5	3	severe	severe	JJ
cord-297178-moxhk2e0	5	4	acute	acute	JJ
cord-297178-moxhk2e0	5	5	respiratory	respiratory	JJ
cord-297178-moxhk2e0	5	6	syndrome	syndrome	NN
cord-297178-moxhk2e0	5	7	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	5	8	2	2	CD
cord-297178-moxhk2e0	6	1	(	(	-LRB-
cord-297178-moxhk2e0	6	2	SARS	SARS	NNP
cord-297178-moxhk2e0	6	3	-	-	HYPH
cord-297178-moxhk2e0	6	4	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	6	5	)	)	-RRB-
cord-297178-moxhk2e0	6	6	,	,	.
cord-297178-moxhk2e0	7	1	the	the	DT
cord-297178-moxhk2e0	7	2	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	7	3	disease	disease	NN
cord-297178-moxhk2e0	7	4	2019	2019	CD
cord-297178-moxhk2e0	7	5	(	(	-LRB-
cord-297178-moxhk2e0	7	6	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	7	7	)	)	-RRB-
cord-297178-moxhk2e0	7	8	is	be	VBZ
cord-297178-moxhk2e0	7	9	provoking	provoke	VBG
cord-297178-moxhk2e0	7	10	devastating	devastating	JJ
cord-297178-moxhk2e0	7	11	consequences	consequence	NNS
cord-297178-moxhk2e0	7	12	on	on	IN
cord-297178-moxhk2e0	7	13	economic	economic	JJ
cord-297178-moxhk2e0	7	14	and	and	CC
cord-297178-moxhk2e0	7	15	social	social	JJ
cord-297178-moxhk2e0	7	16	fields	field	NNS
cord-297178-moxhk2e0	7	17	throughout	throughout	IN
cord-297178-moxhk2e0	7	18	all	all	DT
cord-297178-moxhk2e0	7	19	continents	continent	NNS
cord-297178-moxhk2e0	7	20	.	.	.
cord-297178-moxhk2e0	8	1	Therefore	therefore	RB
cord-297178-moxhk2e0	8	2	,	,	,
cord-297178-moxhk2e0	8	3	pathophysiological	pathophysiological	JJ
cord-297178-moxhk2e0	8	4	knowledge	knowledge	NN
cord-297178-moxhk2e0	8	5	about	about	IN
cord-297178-moxhk2e0	8	6	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	8	7	is	be	VBZ
cord-297178-moxhk2e0	8	8	imperative	imperative	JJ
cord-297178-moxhk2e0	8	9	for	for	IN
cord-297178-moxhk2e0	8	10	better	well	JJR
cord-297178-moxhk2e0	8	11	planning	planning	NN
cord-297178-moxhk2e0	8	12	of	of	IN
cord-297178-moxhk2e0	8	13	preventive	preventive	JJ
cord-297178-moxhk2e0	8	14	measures	measure	NNS
cord-297178-moxhk2e0	8	15	,	,	,
cord-297178-moxhk2e0	8	16	diagnosis	diagnosis	NN
cord-297178-moxhk2e0	8	17	,	,	,
cord-297178-moxhk2e0	8	18	and	and	CC
cord-297178-moxhk2e0	8	19	therapeutics	therapeutic	NNS
cord-297178-moxhk2e0	8	20	of	of	IN
cord-297178-moxhk2e0	8	21	the	the	DT
cord-297178-moxhk2e0	8	22	disease	disease	NN
cord-297178-moxhk2e0	8	23	.	.	.
cord-297178-moxhk2e0	9	1	Based	base	VBN
cord-297178-moxhk2e0	9	2	on	on	IN
cord-297178-moxhk2e0	9	3	previous	previous	JJ
cord-297178-moxhk2e0	9	4	studies	study	NNS
cord-297178-moxhk2e0	9	5	,	,	,
cord-297178-moxhk2e0	9	6	this	this	DT
cord-297178-moxhk2e0	9	7	work	work	NN
cord-297178-moxhk2e0	9	8	proposes	propose	VBZ
cord-297178-moxhk2e0	9	9	new	new	JJ
cord-297178-moxhk2e0	9	10	hypothesis	hypothesis	NN
cord-297178-moxhk2e0	9	11	related	relate	VBN
cord-297178-moxhk2e0	9	12	to	to	IN
cord-297178-moxhk2e0	9	13	the	the	DT
cord-297178-moxhk2e0	9	14	role	role	NN
cord-297178-moxhk2e0	9	15	of	of	IN
cord-297178-moxhk2e0	9	16	the	the	DT
cord-297178-moxhk2e0	9	17	renin	renin	NN
cord-297178-moxhk2e0	9	18	-	-	HYPH
cord-297178-moxhk2e0	9	19	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	9	20	system	system	NN
cord-297178-moxhk2e0	9	21	on	on	IN
cord-297178-moxhk2e0	9	22	the	the	DT
cord-297178-moxhk2e0	9	23	pathophysiology	pathophysiology	NN
cord-297178-moxhk2e0	9	24	of	of	IN
cord-297178-moxhk2e0	9	25	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	9	26	,	,	,
cord-297178-moxhk2e0	9	27	and	and	CC
cord-297178-moxhk2e0	9	28	its	-PRON-	PRP$
cord-297178-moxhk2e0	9	29	purpose	purpose	NN
cord-297178-moxhk2e0	9	30	is	be	VBZ
cord-297178-moxhk2e0	9	31	to	to	TO
cord-297178-moxhk2e0	9	32	enrich	enrich	VB
cord-297178-moxhk2e0	9	33	the	the	DT
cord-297178-moxhk2e0	9	34	discussion	discussion	NN
cord-297178-moxhk2e0	9	35	and	and	CC
cord-297178-moxhk2e0	9	36	to	to	TO
cord-297178-moxhk2e0	9	37	offer	offer	VB
cord-297178-moxhk2e0	9	38	alternative	alternative	JJ
cord-297178-moxhk2e0	9	39	ways	way	NNS
cord-297178-moxhk2e0	9	40	for	for	IN
cord-297178-moxhk2e0	9	41	experimental	experimental	JJ
cord-297178-moxhk2e0	9	42	and	and	CC
cord-297178-moxhk2e0	9	43	clinical	clinical	JJ
cord-297178-moxhk2e0	9	44	studies	study	NNS
cord-297178-moxhk2e0	9	45	aiming	aim	VBG
cord-297178-moxhk2e0	9	46	at	at	IN
cord-297178-moxhk2e0	9	47	the	the	DT
cord-297178-moxhk2e0	9	48	formulation	formulation	NN
cord-297178-moxhk2e0	9	49	of	of	IN
cord-297178-moxhk2e0	9	50	new	new	JJ
cord-297178-moxhk2e0	9	51	diagnosis	diagnosis	NN
cord-297178-moxhk2e0	9	52	and	and	CC
cord-297178-moxhk2e0	9	53	/	/	SYM
cord-297178-moxhk2e0	9	54	or	or	CC
cord-297178-moxhk2e0	9	55	treatment	treatment	NN
cord-297178-moxhk2e0	9	56	methods	method	NNS
cord-297178-moxhk2e0	9	57	.	.	.
cord-297178-moxhk2e0	10	1	The	the	DT
cord-297178-moxhk2e0	10	2	renin	renin	NN
cord-297178-moxhk2e0	10	3	-	-	HYPH
cord-297178-moxhk2e0	10	4	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	10	5	system	system	NN
cord-297178-moxhk2e0	10	6	(	(	-LRB-
cord-297178-moxhk2e0	10	7	RAS	RAS	NNP
cord-297178-moxhk2e0	10	8	)	)	-RRB-
cord-297178-moxhk2e0	10	9	is	be	VBZ
cord-297178-moxhk2e0	10	10	currently	currently	RB
cord-297178-moxhk2e0	10	11	one	one	CD
cord-297178-moxhk2e0	10	12	of	of	IN
cord-297178-moxhk2e0	10	13	the	the	DT
cord-297178-moxhk2e0	10	14	focuses	focus	NNS
cord-297178-moxhk2e0	10	15	of	of	IN
cord-297178-moxhk2e0	10	16	worldwide	worldwide	JJ
cord-297178-moxhk2e0	10	17	research	research	NN
cord-297178-moxhk2e0	10	18	due	due	IN
cord-297178-moxhk2e0	10	19	to	to	IN
cord-297178-moxhk2e0	10	20	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	10	21	2019	2019	CD
cord-297178-moxhk2e0	10	22	(	(	-LRB-
cord-297178-moxhk2e0	10	23	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	10	24	)	)	-RRB-
cord-297178-moxhk2e0	10	25	,	,	,
cord-297178-moxhk2e0	10	26	a	a	DT
cord-297178-moxhk2e0	10	27	pandemic	pandemic	NN
cord-297178-moxhk2e0	10	28	that	that	WDT
cord-297178-moxhk2e0	10	29	has	have	VBZ
cord-297178-moxhk2e0	10	30	destabilized	destabilize	VBN
cord-297178-moxhk2e0	10	31	the	the	DT
cord-297178-moxhk2e0	10	32	world	world	NN
cord-297178-moxhk2e0	10	33	and	and	CC
cord-297178-moxhk2e0	10	34	created	create	VBD
cord-297178-moxhk2e0	10	35	devastating	devastating	JJ
cord-297178-moxhk2e0	10	36	consequences	consequence	NNS
cord-297178-moxhk2e0	10	37	for	for	IN
cord-297178-moxhk2e0	10	38	economic	economic	JJ
cord-297178-moxhk2e0	10	39	and	and	CC
cord-297178-moxhk2e0	10	40	social	social	JJ
cord-297178-moxhk2e0	10	41	areas	area	NNS
cord-297178-moxhk2e0	10	42	[	[	-LRB-
cord-297178-moxhk2e0	10	43	1	1	CD
cord-297178-moxhk2e0	10	44	]	]	-RRB-
cord-297178-moxhk2e0	10	45	[	[	-LRB-
cord-297178-moxhk2e0	10	46	2	2	CD
cord-297178-moxhk2e0	10	47	]	]	-RRB-
cord-297178-moxhk2e0	10	48	[	[	-LRB-
cord-297178-moxhk2e0	10	49	3	3	CD
cord-297178-moxhk2e0	10	50	]	]	-RRB-
cord-297178-moxhk2e0	10	51	.	.	.
cord-297178-moxhk2e0	11	1	Amongst	amongst	IN
cord-297178-moxhk2e0	11	2	the	the	DT
cord-297178-moxhk2e0	11	3	components	component	NNS
cord-297178-moxhk2e0	11	4	of	of	IN
cord-297178-moxhk2e0	11	5	rennin	rennin	NN
cord-297178-moxhk2e0	11	6	-	-	HYPH
cord-297178-moxhk2e0	11	7	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	11	8	system	system	NN
cord-297178-moxhk2e0	11	9	(	(	-LRB-
cord-297178-moxhk2e0	11	10	RAS	RAS	NNP
cord-297178-moxhk2e0	11	11	)	)	-RRB-
cord-297178-moxhk2e0	11	12	,	,	,
cord-297178-moxhk2e0	11	13	the	the	DT
cord-297178-moxhk2e0	11	14	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	11	15	-	-	HYPH
cord-297178-moxhk2e0	11	16	converting	convert	VBG
cord-297178-moxhk2e0	11	17	enzyme	enzyme	NN
cord-297178-moxhk2e0	11	18	2	2	CD
cord-297178-moxhk2e0	11	19	(	(	-LRB-
cord-297178-moxhk2e0	11	20	ACE2	ACE2	NNP
cord-297178-moxhk2e0	11	21	)	)	-RRB-
cord-297178-moxhk2e0	11	22	has	have	VBZ
cord-297178-moxhk2e0	11	23	gained	gain	VBN
cord-297178-moxhk2e0	11	24	great	great	JJ
cord-297178-moxhk2e0	11	25	prominence	prominence	NN
cord-297178-moxhk2e0	11	26	for	for	IN
cord-297178-moxhk2e0	11	27	being	be	VBG
cord-297178-moxhk2e0	11	28	directly	directly	RB
cord-297178-moxhk2e0	11	29	associated	associate	VBN
cord-297178-moxhk2e0	11	30	with	with	IN
cord-297178-moxhk2e0	11	31	severe	severe	JJ
cord-297178-moxhk2e0	11	32	acute	acute	JJ
cord-297178-moxhk2e0	11	33	respiratory	respiratory	JJ
cord-297178-moxhk2e0	11	34	syndrome	syndrome	NN
cord-297178-moxhk2e0	11	35	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	11	36	2	2	CD
cord-297178-moxhk2e0	12	1	(	(	-LRB-
cord-297178-moxhk2e0	12	2	SARS	SARS	NNP
cord-297178-moxhk2e0	12	3	-	-	HYPH
cord-297178-moxhk2e0	12	4	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	12	5	)	)	-RRB-
cord-297178-moxhk2e0	12	6	infection	infection	NN
cord-297178-moxhk2e0	12	7	,	,	,
cord-297178-moxhk2e0	12	8	the	the	DT
cord-297178-moxhk2e0	12	9	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	12	10	related	relate	VBN
cord-297178-moxhk2e0	12	11	to	to	IN
cord-297178-moxhk2e0	12	12	COVID-19	covid-19	VB
cord-297178-moxhk2e0	12	13	[	[	-LRB-
cord-297178-moxhk2e0	12	14	4	4	CD
cord-297178-moxhk2e0	12	15	,	,	,
cord-297178-moxhk2e0	12	16	5	5	CD
cord-297178-moxhk2e0	12	17	]	]	-RRB-
cord-297178-moxhk2e0	12	18	.	.	.
cord-297178-moxhk2e0	13	1	Thus	thus	RB
cord-297178-moxhk2e0	13	2	,	,	,
cord-297178-moxhk2e0	13	3	the	the	DT
cord-297178-moxhk2e0	13	4	protagonism	protagonism	NN
cord-297178-moxhk2e0	13	5	of	of	IN
cord-297178-moxhk2e0	13	6	ACE2	ACE2	NNP
cord-297178-moxhk2e0	13	7	is	be	VBZ
cord-297178-moxhk2e0	13	8	being	be	VBG
cord-297178-moxhk2e0	13	9	debated	debate	VBN
cord-297178-moxhk2e0	13	10	amongst	amongst	IN
cord-297178-moxhk2e0	13	11	researchers	researcher	NNS
cord-297178-moxhk2e0	13	12	with	with	IN
cord-297178-moxhk2e0	13	13	the	the	DT
cord-297178-moxhk2e0	13	14	aim	aim	NN
cord-297178-moxhk2e0	13	15	of	of	IN
cord-297178-moxhk2e0	13	16	establishing	establish	VBG
cord-297178-moxhk2e0	13	17	a	a	DT
cord-297178-moxhk2e0	13	18	role	role	NN
cord-297178-moxhk2e0	13	19	of	of	IN
cord-297178-moxhk2e0	13	20	RAS	RAS	NNP
cord-297178-moxhk2e0	13	21	on	on	IN
cord-297178-moxhk2e0	13	22	the	the	DT
cord-297178-moxhk2e0	13	23	pathophysiologic	pathophysiologic	JJ
cord-297178-moxhk2e0	13	24	context	context	NN
cord-297178-moxhk2e0	13	25	of	of	IN
cord-297178-moxhk2e0	13	26	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	13	27	[	[	-LRB-
cord-297178-moxhk2e0	13	28	6	6	CD
cord-297178-moxhk2e0	13	29	]	]	-RRB-
cord-297178-moxhk2e0	13	30	[	[	-LRB-
cord-297178-moxhk2e0	13	31	7	7	CD
cord-297178-moxhk2e0	13	32	]	]	-RRB-
cord-297178-moxhk2e0	14	1	[	[	-LRB-
cord-297178-moxhk2e0	14	2	8	8	CD
cord-297178-moxhk2e0	14	3	]	]	-RRB-
cord-297178-moxhk2e0	14	4	.	.	.
cord-297178-moxhk2e0	15	1	RAS	RAS	NNP
cord-297178-moxhk2e0	15	2	was	be	VBD
cord-297178-moxhk2e0	15	3	initially	initially	RB
cord-297178-moxhk2e0	15	4	described	describe	VBN
cord-297178-moxhk2e0	15	5	as	as	IN
cord-297178-moxhk2e0	15	6	a	a	DT
cord-297178-moxhk2e0	15	7	regulating	regulating	NN
cord-297178-moxhk2e0	15	8	component	component	NN
cord-297178-moxhk2e0	15	9	of	of	IN
cord-297178-moxhk2e0	15	10	blood	blood	NN
cord-297178-moxhk2e0	15	11	pressure	pressure	NN
cord-297178-moxhk2e0	15	12	and	and	CC
cord-297178-moxhk2e0	15	13	hydric	hydric	NN
cord-297178-moxhk2e0	15	14	balance	balance	NN
cord-297178-moxhk2e0	15	15	,	,	,
cord-297178-moxhk2e0	15	16	being	be	VBG
cord-297178-moxhk2e0	15	17	called	call	VBN
cord-297178-moxhk2e0	15	18	"	"	``
cord-297178-moxhk2e0	15	19	classic	classic	JJ
cord-297178-moxhk2e0	15	20	pathway	pathway	NN
cord-297178-moxhk2e0	15	21	"	"	''
cord-297178-moxhk2e0	15	22	.	.	.
cord-297178-moxhk2e0	16	1	Subsequently	subsequently	RB
cord-297178-moxhk2e0	16	2	,	,	,
cord-297178-moxhk2e0	16	3	with	with	IN
cord-297178-moxhk2e0	16	4	the	the	DT
cord-297178-moxhk2e0	16	5	discovery	discovery	NN
cord-297178-moxhk2e0	16	6	of	of	IN
cord-297178-moxhk2e0	16	7	new	new	JJ
cord-297178-moxhk2e0	16	8	components	component	NNS
cord-297178-moxhk2e0	16	9	and	and	CC
cord-297178-moxhk2e0	16	10	finding	finding	NN
cord-297178-moxhk2e0	16	11	of	of	IN
cord-297178-moxhk2e0	16	12	a	a	DT
cord-297178-moxhk2e0	16	13	"	"	``
cord-297178-moxhk2e0	16	14	local	local	JJ
cord-297178-moxhk2e0	16	15	tissue	tissue	NN
cord-297178-moxhk2e0	16	16	RAS	RAS	NNP
cord-297178-moxhk2e0	16	17	"	"	''
cord-297178-moxhk2e0	16	18	,	,	,
cord-297178-moxhk2e0	16	19	the	the	DT
cord-297178-moxhk2e0	16	20	existence	existence	NN
cord-297178-moxhk2e0	16	21	of	of	IN
cord-297178-moxhk2e0	16	22	a	a	DT
cord-297178-moxhk2e0	16	23	more	more	RBR
cord-297178-moxhk2e0	16	24	complex	complex	JJ
cord-297178-moxhk2e0	16	25	system	system	NN
cord-297178-moxhk2e0	16	26	was	be	VBD
cord-297178-moxhk2e0	16	27	observed	observe	VBN
cord-297178-moxhk2e0	16	28	with	with	IN
cord-297178-moxhk2e0	16	29	endocrine	endocrine	NN
cord-297178-moxhk2e0	16	30	,	,	,
cord-297178-moxhk2e0	16	31	paracrine	paracrine	JJ
cord-297178-moxhk2e0	16	32	and	and	CC
cord-297178-moxhk2e0	16	33	intracrine	intracrine	JJ
cord-297178-moxhk2e0	16	34	characteristics	characteristic	NNS
cord-297178-moxhk2e0	16	35	[	[	-LRB-
cord-297178-moxhk2e0	16	36	9	9	CD
cord-297178-moxhk2e0	16	37	]	]	-RRB-
cord-297178-moxhk2e0	16	38	[	[	-LRB-
cord-297178-moxhk2e0	16	39	10	10	CD
cord-297178-moxhk2e0	16	40	]	]	-RRB-
cord-297178-moxhk2e0	16	41	[	[	-LRB-
cord-297178-moxhk2e0	16	42	11	11	CD
cord-297178-moxhk2e0	16	43	]	]	-RRB-
cord-297178-moxhk2e0	16	44	.	.	.
cord-297178-moxhk2e0	17	1	RAS	RAS	NNP
cord-297178-moxhk2e0	17	2	elucidation	elucidation	NN
cord-297178-moxhk2e0	17	3	continues	continue	VBZ
cord-297178-moxhk2e0	17	4	to	to	TO
cord-297178-moxhk2e0	17	5	expand	expand	VB
cord-297178-moxhk2e0	17	6	,	,	,
cord-297178-moxhk2e0	17	7	new	new	JJ
cord-297178-moxhk2e0	17	8	components	component	NNS
cord-297178-moxhk2e0	17	9	are	be	VBP
cord-297178-moxhk2e0	17	10	being	be	VBG
cord-297178-moxhk2e0	17	11	discovered	discover	VBN
cord-297178-moxhk2e0	17	12	and	and	CC
cord-297178-moxhk2e0	17	13	also	also	RB
cord-297178-moxhk2e0	17	14	new	new	JJ
cord-297178-moxhk2e0	17	15	ways	way	NNS
cord-297178-moxhk2e0	17	16	of	of	IN
cord-297178-moxhk2e0	17	17	interaction	interaction	NN
cord-297178-moxhk2e0	17	18	between	between	IN
cord-297178-moxhk2e0	17	19	the	the	DT
cord-297178-moxhk2e0	17	20	local	local	JJ
cord-297178-moxhk2e0	17	21	and	and	CC
cord-297178-moxhk2e0	17	22	systemic	systemic	JJ
cord-297178-moxhk2e0	17	23	pathways	pathway	NNS
cord-297178-moxhk2e0	17	24	,	,	,
cord-297178-moxhk2e0	17	25	as	as	RB
cord-297178-moxhk2e0	17	26	well	well	RB
cord-297178-moxhk2e0	17	27	as	as	IN
cord-297178-moxhk2e0	17	28	interactions	interaction	NNS
cord-297178-moxhk2e0	17	29	with	with	IN
cord-297178-moxhk2e0	17	30	the	the	DT
cord-297178-moxhk2e0	17	31	external	external	JJ
cord-297178-moxhk2e0	17	32	environment	environment	NN
cord-297178-moxhk2e0	17	33	[	[	-LRB-
cord-297178-moxhk2e0	17	34	12	12	CD
cord-297178-moxhk2e0	17	35	]	]	-RRB-
cord-297178-moxhk2e0	17	36	.	.	.
cord-297178-moxhk2e0	18	1	Nowadays	nowadays	RB
cord-297178-moxhk2e0	18	2	,	,	,
cord-297178-moxhk2e0	18	3	RAS	RAS	NNP
cord-297178-moxhk2e0	18	4	is	be	VBZ
cord-297178-moxhk2e0	18	5	known	know	VBN
cord-297178-moxhk2e0	18	6	as	as	IN
cord-297178-moxhk2e0	18	7	a	a	DT
cord-297178-moxhk2e0	18	8	complex	complex	JJ
cord-297178-moxhk2e0	18	9	system	system	NN
cord-297178-moxhk2e0	18	10	,	,	,
cord-297178-moxhk2e0	18	11	with	with	IN
cord-297178-moxhk2e0	18	12	systemic	systemic	JJ
cord-297178-moxhk2e0	18	13	and	and	CC
cord-297178-moxhk2e0	18	14	local	local	JJ
cord-297178-moxhk2e0	18	15	(	(	-LRB-
cord-297178-moxhk2e0	18	16	tissue	tissue	NN
cord-297178-moxhk2e0	18	17	)	)	-RRB-
cord-297178-moxhk2e0	18	18	activities	activity	NNS
cord-297178-moxhk2e0	18	19	which	which	WDT
cord-297178-moxhk2e0	18	20	communicate	communicate	VBP
cord-297178-moxhk2e0	18	21	between	between	IN
cord-297178-moxhk2e0	18	22	themselves	-PRON-	PRP
cord-297178-moxhk2e0	18	23	and	and	CC
cord-297178-moxhk2e0	18	24	involve	involve	VBP
cord-297178-moxhk2e0	18	25	different	different	JJ
cord-297178-moxhk2e0	18	26	sign	sign	NN
cord-297178-moxhk2e0	18	27	pathways	pathway	NNS
cord-297178-moxhk2e0	18	28	,	,	,
cord-297178-moxhk2e0	18	29	leading	lead	VBG
cord-297178-moxhk2e0	18	30	to	to	IN
cord-297178-moxhk2e0	18	31	different	different	JJ
cord-297178-moxhk2e0	18	32	results	result	NNS
cord-297178-moxhk2e0	18	33	depending	depend	VBG
cord-297178-moxhk2e0	18	34	on	on	IN
cord-297178-moxhk2e0	18	35	the	the	DT
cord-297178-moxhk2e0	18	36	chosen	choose	VBN
cord-297178-moxhk2e0	18	37	pathway	pathway	NN
cord-297178-moxhk2e0	18	38	[	[	-LRB-
cord-297178-moxhk2e0	18	39	9	9	CD
cord-297178-moxhk2e0	18	40	,	,	,
cord-297178-moxhk2e0	18	41	12	12	CD
cord-297178-moxhk2e0	18	42	]	]	-RRB-
cord-297178-moxhk2e0	18	43	.	.	.
cord-297178-moxhk2e0	19	1	This	this	DT
cord-297178-moxhk2e0	19	2	system	system	NN
cord-297178-moxhk2e0	19	3	's	's	POS
cord-297178-moxhk2e0	19	4	balance	balance	NN
cord-297178-moxhk2e0	19	5	is	be	VBZ
cord-297178-moxhk2e0	19	6	imperative	imperative	JJ
cord-297178-moxhk2e0	19	7	for	for	IN
cord-297178-moxhk2e0	19	8	homeostasis	homeostasis	NN
cord-297178-moxhk2e0	19	9	,	,	,
cord-297178-moxhk2e0	19	10	in	in	IN
cord-297178-moxhk2e0	19	11	which	which	WDT
cord-297178-moxhk2e0	19	12	the	the	DT
cord-297178-moxhk2e0	19	13	angiotensinconverting	angiotensinconverting	NN
cord-297178-moxhk2e0	19	14	enzyme	enzyme	NN
cord-297178-moxhk2e0	19	15	(	(	-LRB-
cord-297178-moxhk2e0	19	16	ACE	ACE	NNP
cord-297178-moxhk2e0	19	17	)	)	-RRB-
cord-297178-moxhk2e0	19	18	and	and	CC
cord-297178-moxhk2e0	19	19	ACE2	ACE2	NNP
cord-297178-moxhk2e0	19	20	are	be	VBP
cord-297178-moxhk2e0	19	21	the	the	DT
cord-297178-moxhk2e0	19	22	main	main	JJ
cord-297178-moxhk2e0	19	23	weights	weight	NNS
cord-297178-moxhk2e0	19	24	in	in	IN
cord-297178-moxhk2e0	19	25	this	this	DT
cord-297178-moxhk2e0	19	26	scale	scale	NN
cord-297178-moxhk2e0	19	27	(	(	-LRB-
cord-297178-moxhk2e0	19	28	Figure	figure	NN
cord-297178-moxhk2e0	19	29	  	  	_SP
cord-297178-moxhk2e0	19	30	1	1	CD
cord-297178-moxhk2e0	19	31	)	)	-RRB-
cord-297178-moxhk2e0	19	32	.	.	.
cord-297178-moxhk2e0	20	1	When	when	WRB
cord-297178-moxhk2e0	20	2	the	the	DT
cord-297178-moxhk2e0	20	3	scale	scale	NN
cord-297178-moxhk2e0	20	4	plate	plate	NN
cord-297178-moxhk2e0	20	5	tends	tend	VBZ
cord-297178-moxhk2e0	20	6	to	to	IN
cord-297178-moxhk2e0	20	7	the	the	DT
cord-297178-moxhk2e0	20	8	ACE	ACE	NNP
cord-297178-moxhk2e0	20	9	side	side	NN
cord-297178-moxhk2e0	20	10	,	,	,
cord-297178-moxhk2e0	20	11	the	the	DT
cord-297178-moxhk2e0	20	12	production	production	NN
cord-297178-moxhk2e0	20	13	of	of	IN
cord-297178-moxhk2e0	20	14	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	20	15	II	II	NNP
cord-297178-moxhk2e0	20	16	(	(	-LRB-
cord-297178-moxhk2e0	20	17	Ang	Ang	NNP
cord-297178-moxhk2e0	20	18	II	II	NNP
cord-297178-moxhk2e0	20	19	)	)	-RRB-
cord-297178-moxhk2e0	20	20	and	and	CC
cord-297178-moxhk2e0	20	21	the	the	DT
cord-297178-moxhk2e0	20	22	activation	activation	NN
cord-297178-moxhk2e0	20	23	of	of	IN
cord-297178-moxhk2e0	20	24	its	-PRON-	PRP$
cord-297178-moxhk2e0	20	25	respective	respective	JJ
cord-297178-moxhk2e0	20	26	receptors	receptor	NNS
cord-297178-moxhk2e0	20	27	(	(	-LRB-
cord-297178-moxhk2e0	20	28	AT1	AT1	NNP
cord-297178-moxhk2e0	20	29	)	)	-RRB-
cord-297178-moxhk2e0	20	30	increases	increase	NNS
cord-297178-moxhk2e0	20	31	.	.	.
cord-297178-moxhk2e0	21	1	The	the	DT
cord-297178-moxhk2e0	21	2	3	3	CD
cord-297178-moxhk2e0	21	3	activation	activation	NN
cord-297178-moxhk2e0	21	4	of	of	IN
cord-297178-moxhk2e0	21	5	the	the	DT
cord-297178-moxhk2e0	21	6	detrimental	detrimental	JJ
cord-297178-moxhk2e0	21	7	pathway	pathway	NN
cord-297178-moxhk2e0	21	8	(	(	-LRB-
cord-297178-moxhk2e0	21	9	ACE	ACE	NNP
cord-297178-moxhk2e0	21	10	-Ang	-Ang	HYPH
cord-297178-moxhk2e0	21	11	II	II	NNP
cord-297178-moxhk2e0	21	12	-AT1R	-AT1R	NNS
cord-297178-moxhk2e0	21	13	)	)	-RRB-
cord-297178-moxhk2e0	21	14	stimulates	stimulate	VBZ
cord-297178-moxhk2e0	21	15	actions	action	NNS
cord-297178-moxhk2e0	21	16	such	such	JJ
cord-297178-moxhk2e0	21	17	as	as	IN
cord-297178-moxhk2e0	21	18	cell	cell	NN
cord-297178-moxhk2e0	21	19	proliferation	proliferation	NN
cord-297178-moxhk2e0	21	20	,	,	,
cord-297178-moxhk2e0	21	21	inflammation	inflammation	NN
cord-297178-moxhk2e0	21	22	,	,	,
cord-297178-moxhk2e0	21	23	fibrosis	fibrosis	NN
cord-297178-moxhk2e0	21	24	,	,	,
cord-297178-moxhk2e0	21	25	and	and	CC
cord-297178-moxhk2e0	21	26	thrombosis	thrombosis	NN
cord-297178-moxhk2e0	21	27	.	.	.
cord-297178-moxhk2e0	22	1	On	on	IN
cord-297178-moxhk2e0	22	2	the	the	DT
cord-297178-moxhk2e0	22	3	other	other	JJ
cord-297178-moxhk2e0	22	4	hand	hand	NN
cord-297178-moxhk2e0	22	5	,	,	,
cord-297178-moxhk2e0	22	6	when	when	WRB
cord-297178-moxhk2e0	22	7	the	the	DT
cord-297178-moxhk2e0	22	8	scale	scale	NN
cord-297178-moxhk2e0	22	9	plate	plate	NN
cord-297178-moxhk2e0	22	10	tends	tend	VBZ
cord-297178-moxhk2e0	22	11	to	to	IN
cord-297178-moxhk2e0	22	12	the	the	DT
cord-297178-moxhk2e0	22	13	ACE2	ACE2	NNP
cord-297178-moxhk2e0	22	14	side	side	NN
cord-297178-moxhk2e0	22	15	,	,	,
cord-297178-moxhk2e0	22	16	the	the	DT
cord-297178-moxhk2e0	22	17	production	production	NN
cord-297178-moxhk2e0	22	18	of	of	IN
cord-297178-moxhk2e0	22	19	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	22	20	1	1	CD
cord-297178-moxhk2e0	22	21	-	-	SYM
cord-297178-moxhk2e0	22	22	7	7	CD
cord-297178-moxhk2e0	22	23	(	(	-LRB-
cord-297178-moxhk2e0	22	24	Ang	Ang	NNP
cord-297178-moxhk2e0	22	25	1	1	CD
cord-297178-moxhk2e0	22	26	-	-	SYM
cord-297178-moxhk2e0	22	27	7	7	CD
cord-297178-moxhk2e0	22	28	)	)	-RRB-
cord-297178-moxhk2e0	22	29	increases	increase	NNS
cord-297178-moxhk2e0	22	30	,	,	,
cord-297178-moxhk2e0	22	31	as	as	RB
cord-297178-moxhk2e0	22	32	well	well	RB
cord-297178-moxhk2e0	22	33	as	as	IN
cord-297178-moxhk2e0	22	34	the	the	DT
cord-297178-moxhk2e0	22	35	activation	activation	NN
cord-297178-moxhk2e0	22	36	of	of	IN
cord-297178-moxhk2e0	22	37	its	-PRON-	PRP$
cord-297178-moxhk2e0	22	38	respective	respective	JJ
cord-297178-moxhk2e0	22	39	receptors	receptor	NNS
cord-297178-moxhk2e0	22	40	(	(	-LRB-
cord-297178-moxhk2e0	22	41	Mas	Mas	NNP
cord-297178-moxhk2e0	22	42	)	)	-RRB-
cord-297178-moxhk2e0	22	43	[	[	-LRB-
cord-297178-moxhk2e0	22	44	13	13	CD
cord-297178-moxhk2e0	22	45	]	]	-RRB-
cord-297178-moxhk2e0	22	46	.	.	.
cord-297178-moxhk2e0	23	1	The	the	DT
cord-297178-moxhk2e0	23	2	activation	activation	NN
cord-297178-moxhk2e0	23	3	of	of	IN
cord-297178-moxhk2e0	23	4	the	the	DT
cord-297178-moxhk2e0	23	5	protective	protective	JJ
cord-297178-moxhk2e0	23	6	pathway	pathway	NN
cord-297178-moxhk2e0	23	7	(	(	-LRB-
cord-297178-moxhk2e0	23	8	ACE2	ACE2	NNP
cord-297178-moxhk2e0	23	9	-Ang	-ang	JJ
cord-297178-moxhk2e0	23	10	1	1	CD
cord-297178-moxhk2e0	23	11	-	-	SYM
cord-297178-moxhk2e0	23	12	7	7	CD
cord-297178-moxhk2e0	23	13	-Mas	-mas	ADD
cord-297178-moxhk2e0	23	14	)	)	-RRB-
cord-297178-moxhk2e0	23	15	neutralizes	neutralize	VBZ
cord-297178-moxhk2e0	23	16	the	the	DT
cord-297178-moxhk2e0	23	17	detrimental	detrimental	JJ
cord-297178-moxhk2e0	23	18	pathway	pathway	NN
cord-297178-moxhk2e0	23	19	,	,	,
cord-297178-moxhk2e0	23	20	stimulating	stimulate	VBG
cord-297178-moxhk2e0	23	21	actions	action	NNS
cord-297178-moxhk2e0	23	22	such	such	JJ
cord-297178-moxhk2e0	23	23	as	as	IN
cord-297178-moxhk2e0	23	24	antiinflammatory	antiinflammatory	JJ
cord-297178-moxhk2e0	23	25	,	,	,
cord-297178-moxhk2e0	23	26	anti	anti	JJ
cord-297178-moxhk2e0	23	27	-	-	JJ
cord-297178-moxhk2e0	23	28	fibrotic	fibrotic	JJ
cord-297178-moxhk2e0	23	29	,	,	,
cord-297178-moxhk2e0	23	30	and	and	CC
cord-297178-moxhk2e0	23	31	anti	anti	JJ
cord-297178-moxhk2e0	23	32	-	-	JJ
cord-297178-moxhk2e0	23	33	thrombotic	thrombotic	JJ
cord-297178-moxhk2e0	23	34	effects	effect	NNS
cord-297178-moxhk2e0	23	35	[	[	-LRB-
cord-297178-moxhk2e0	23	36	9	9	CD
cord-297178-moxhk2e0	23	37	,	,	,
cord-297178-moxhk2e0	23	38	14	14	CD
cord-297178-moxhk2e0	23	39	]	]	-RRB-
cord-297178-moxhk2e0	23	40	.	.	.
cord-297178-moxhk2e0	24	1	Coronaviruses	coronaviruse	NNS
cord-297178-moxhk2e0	24	2	are	be	VBP
cord-297178-moxhk2e0	24	3	classified	classify	VBN
cord-297178-moxhk2e0	24	4	into	into	IN
cord-297178-moxhk2e0	24	5	four	four	CD
cord-297178-moxhk2e0	24	6	different	different	JJ
cord-297178-moxhk2e0	24	7	genus	genus	NN
cord-297178-moxhk2e0	24	8	,	,	,
cord-297178-moxhk2e0	24	9	in	in	IN
cord-297178-moxhk2e0	24	10	which	which	WDT
cord-297178-moxhk2e0	24	11	3	3	CD
cord-297178-moxhk2e0	24	12	species	specie	NNS
cord-297178-moxhk2e0	24	13	(	(	-LRB-
cord-297178-moxhk2e0	24	14	α	α	XX
cord-297178-moxhk2e0	24	15	HCoV	HCoV	NNP
cord-297178-moxhk2e0	24	16	-	-	HYPH
cord-297178-moxhk2e0	24	17	NL63	NL63	NNP
cord-297178-moxhk2e0	24	18	,	,	,
cord-297178-moxhk2e0	24	19	SARS	SARS	NNP
cord-297178-moxhk2e0	24	20	-	-	HYPH
cord-297178-moxhk2e0	24	21	CoV	CoV	NNP
cord-297178-moxhk2e0	24	22	,	,	,
cord-297178-moxhk2e0	24	23	and	and	CC
cord-297178-moxhk2e0	24	24	SARS	SARS	NNP
cord-297178-moxhk2e0	24	25	-	-	HYPH
cord-297178-moxhk2e0	24	26	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	24	27	)	)	-RRB-
cord-297178-moxhk2e0	24	28	have	have	VBP
cord-297178-moxhk2e0	24	29	ACE2	ACE2	NNP
cord-297178-moxhk2e0	24	30	as	as	IN
cord-297178-moxhk2e0	24	31	a	a	DT
cord-297178-moxhk2e0	24	32	receptor	receptor	NN
cord-297178-moxhk2e0	24	33	[	[	-LRB-
cord-297178-moxhk2e0	24	34	15	15	CD
cord-297178-moxhk2e0	24	35	]	]	-RRB-
cord-297178-moxhk2e0	24	36	.	.	.
cord-297178-moxhk2e0	25	1	The	the	DT
cord-297178-moxhk2e0	25	2	process	process	NN
cord-297178-moxhk2e0	25	3	of	of	IN
cord-297178-moxhk2e0	25	4	cell	cell	NN
cord-297178-moxhk2e0	25	5	invasion	invasion	NN
cord-297178-moxhk2e0	25	6	occurs	occur	VBZ
cord-297178-moxhk2e0	25	7	similarly	similarly	RB
cord-297178-moxhk2e0	25	8	amongst	amongst	IN
cord-297178-moxhk2e0	25	9	the	the	DT
cord-297178-moxhk2e0	25	10	different	different	JJ
cord-297178-moxhk2e0	25	11	species	specie	NNS
cord-297178-moxhk2e0	25	12	.	.	.
cord-297178-moxhk2e0	26	1	Briefly	briefly	RB
cord-297178-moxhk2e0	26	2	,	,	,
cord-297178-moxhk2e0	26	3	the	the	DT
cord-297178-moxhk2e0	26	4	virus	virus	NN
cord-297178-moxhk2e0	26	5	-	-	HYPH
cord-297178-moxhk2e0	26	6	cell	cell	NN
cord-297178-moxhk2e0	26	7	interaction	interaction	NN
cord-297178-moxhk2e0	26	8	occurs	occur	VBZ
cord-297178-moxhk2e0	26	9	through	through	IN
cord-297178-moxhk2e0	26	10	the	the	DT
cord-297178-moxhk2e0	26	11	ACE2	ACE2	NNP
cord-297178-moxhk2e0	26	12	receptor	receptor	NN
cord-297178-moxhk2e0	26	13	coupling	coupling	NN
cord-297178-moxhk2e0	26	14	,	,	,
cord-297178-moxhk2e0	26	15	and	and	CC
cord-297178-moxhk2e0	26	16	the	the	DT
cord-297178-moxhk2e0	26	17	internalization	internalization	NN
cord-297178-moxhk2e0	26	18	of	of	IN
cord-297178-moxhk2e0	26	19	the	the	DT
cord-297178-moxhk2e0	26	20	virus	virus	NN
cord-297178-moxhk2e0	26	21	then	then	RB
cord-297178-moxhk2e0	26	22	occurs	occur	VBZ
cord-297178-moxhk2e0	26	23	through	through	IN
cord-297178-moxhk2e0	26	24	fusion	fusion	NN
cord-297178-moxhk2e0	26	25	or	or	CC
cord-297178-moxhk2e0	26	26	endocytosis	endocytosis	NN
cord-297178-moxhk2e0	26	27	,	,	,
cord-297178-moxhk2e0	26	28	with	with	IN
cord-297178-moxhk2e0	26	29	the	the	DT
cord-297178-moxhk2e0	26	30	participation	participation	NN
cord-297178-moxhk2e0	26	31	of	of	IN
cord-297178-moxhk2e0	26	32	other	other	JJ
cord-297178-moxhk2e0	26	33	components	component	NNS
cord-297178-moxhk2e0	26	34	(	(	-LRB-
cord-297178-moxhk2e0	26	35	clathrin	clathrin	NNP
cord-297178-moxhk2e0	26	36	,	,	,
cord-297178-moxhk2e0	26	37	TMPRSS2	TMPRSS2	NNP
cord-297178-moxhk2e0	26	38	,	,	,
cord-297178-moxhk2e0	26	39	and	and	CC
cord-297178-moxhk2e0	26	40	others	other	NNS
cord-297178-moxhk2e0	26	41	)	)	-RRB-
cord-297178-moxhk2e0	26	42	[	[	-LRB-
cord-297178-moxhk2e0	26	43	16	16	CD
cord-297178-moxhk2e0	26	44	]	]	-RRB-
cord-297178-moxhk2e0	26	45	[	[	-LRB-
cord-297178-moxhk2e0	26	46	17	17	CD
cord-297178-moxhk2e0	26	47	]	]	-RRB-
cord-297178-moxhk2e0	26	48	[	[	-LRB-
cord-297178-moxhk2e0	26	49	18	18	CD
cord-297178-moxhk2e0	26	50	]	]	-RRB-
cord-297178-moxhk2e0	26	51	.	.	.
cord-297178-moxhk2e0	27	1	Although	although	IN
cord-297178-moxhk2e0	27	2	they	-PRON-	PRP
cord-297178-moxhk2e0	27	3	belong	belong	VBP
cord-297178-moxhk2e0	27	4	to	to	IN
cord-297178-moxhk2e0	27	5	the	the	DT
cord-297178-moxhk2e0	27	6	same	same	JJ
cord-297178-moxhk2e0	27	7	subfamily	subfamily	NN
cord-297178-moxhk2e0	27	8	Coronavirinae	Coronavirinae	NNP
cord-297178-moxhk2e0	27	9	and	and	CC
cord-297178-moxhk2e0	27	10	share	share	VB
cord-297178-moxhk2e0	27	11	the	the	DT
cord-297178-moxhk2e0	27	12	same	same	JJ
cord-297178-moxhk2e0	27	13	receptor	receptor	NN
cord-297178-moxhk2e0	27	14	,	,	,
cord-297178-moxhk2e0	27	15	these	these	DT
cord-297178-moxhk2e0	27	16	viruses	virus	NNS
cord-297178-moxhk2e0	27	17	have	have	VBP
cord-297178-moxhk2e0	27	18	significant	significant	JJ
cord-297178-moxhk2e0	27	19	differences	difference	NNS
cord-297178-moxhk2e0	27	20	,	,	,
cord-297178-moxhk2e0	27	21	as	as	IN
cord-297178-moxhk2e0	27	22	presented	present	VBN
cord-297178-moxhk2e0	27	23	in	in	IN
cord-297178-moxhk2e0	27	24	Table	Table	NNP
cord-297178-moxhk2e0	27	25	1	1	CD
cord-297178-moxhk2e0	27	26	.	.	.
cord-297178-moxhk2e0	28	1	Amongst	amongst	IN
cord-297178-moxhk2e0	28	2	these	these	DT
cord-297178-moxhk2e0	28	3	differences	difference	NNS
cord-297178-moxhk2e0	28	4	,	,	,
cord-297178-moxhk2e0	28	5	it	-PRON-	PRP
cord-297178-moxhk2e0	28	6	is	be	VBZ
cord-297178-moxhk2e0	28	7	important	important	JJ
cord-297178-moxhk2e0	28	8	to	to	TO
cord-297178-moxhk2e0	28	9	highlight	highlight	VB
cord-297178-moxhk2e0	28	10	in	in	IN
cord-297178-moxhk2e0	28	11	SARS	SARS	NNP
cord-297178-moxhk2e0	28	12	-	-	HYPH
cord-297178-moxhk2e0	28	13	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	28	14	(	(	-LRB-
cord-297178-moxhk2e0	28	15	the	the	DT
cord-297178-moxhk2e0	28	16	virus	virus	NN
cord-297178-moxhk2e0	28	17	related	relate	VBN
cord-297178-moxhk2e0	28	18	to	to	IN
cord-297178-moxhk2e0	28	19	COVID-19	covid-19	VB
cord-297178-moxhk2e0	28	20	)	)	-RRB-
cord-297178-moxhk2e0	28	21	the	the	DT
cord-297178-moxhk2e0	28	22	longer	long	JJR
cord-297178-moxhk2e0	28	23	incubation	incubation	NN
cord-297178-moxhk2e0	28	24	period	period	NN
cord-297178-moxhk2e0	28	25	and	and	CC
cord-297178-moxhk2e0	28	26	the	the	DT
cord-297178-moxhk2e0	28	27	faster	fast	JJR
cord-297178-moxhk2e0	28	28	viral	viral	JJ
cord-297178-moxhk2e0	28	29	peak	peak	NN
cord-297178-moxhk2e0	28	30	,	,	,
cord-297178-moxhk2e0	28	31	observed	observe	VBD
cord-297178-moxhk2e0	28	32	a	a	DT
cord-297178-moxhk2e0	28	33	few	few	JJ
cord-297178-moxhk2e0	28	34	days	day	NNS
cord-297178-moxhk2e0	28	35	after	after	IN
cord-297178-moxhk2e0	28	36	the	the	DT
cord-297178-moxhk2e0	28	37	beginning	beginning	NN
cord-297178-moxhk2e0	28	38	of	of	IN
cord-297178-moxhk2e0	28	39	symptoms	symptom	NNS
cord-297178-moxhk2e0	28	40	.	.	.
cord-297178-moxhk2e0	29	1	Such	such	JJ
cord-297178-moxhk2e0	29	2	characteristics	characteristic	NNS
cord-297178-moxhk2e0	29	3	might	may	MD
cord-297178-moxhk2e0	29	4	be	be	VB
cord-297178-moxhk2e0	29	5	related	relate	VBN
cord-297178-moxhk2e0	29	6	to	to	IN
cord-297178-moxhk2e0	29	7	the	the	DT
cord-297178-moxhk2e0	29	8	fact	fact	NN
cord-297178-moxhk2e0	29	9	that	that	IN
cord-297178-moxhk2e0	29	10	SARS	SARS	NNP
cord-297178-moxhk2e0	29	11	-	-	HYPH
cord-297178-moxhk2e0	29	12	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	29	13	presents	present	VBZ
cord-297178-moxhk2e0	29	14	the	the	DT
cord-297178-moxhk2e0	29	15	most	most	RBS
cord-297178-moxhk2e0	29	16	extreme	extreme	JJ
cord-297178-moxhk2e0	29	17	deficiency	deficiency	NN
cord-297178-moxhk2e0	29	18	of	of	IN
cord-297178-moxhk2e0	29	19	CpG	CpG	NNP
cord-297178-moxhk2e0	29	20	amongst	amongst	IN
cord-297178-moxhk2e0	29	21	the	the	DT
cord-297178-moxhk2e0	29	22	known	know	VBN
cord-297178-moxhk2e0	29	23	betacoronavirus	betacoronavirus	NN
cord-297178-moxhk2e0	29	24	genomes	genome	NNS
cord-297178-moxhk2e0	29	25	.	.	.
cord-297178-moxhk2e0	30	1	The	the	DT
cord-297178-moxhk2e0	30	2	reduction	reduction	NN
cord-297178-moxhk2e0	30	3	of	of	IN
cord-297178-moxhk2e0	30	4	the	the	DT
cord-297178-moxhk2e0	30	5	CpG	CpG	NNP
cord-297178-moxhk2e0	30	6	index	index	NN
cord-297178-moxhk2e0	30	7	may	may	MD
cord-297178-moxhk2e0	30	8	have	have	VB
cord-297178-moxhk2e0	30	9	allowed	allow	VBN
cord-297178-moxhk2e0	30	10	the	the	DT
cord-297178-moxhk2e0	30	11	virus	virus	NN
cord-297178-moxhk2e0	30	12	to	to	TO
cord-297178-moxhk2e0	30	13	escape	escape	VB
cord-297178-moxhk2e0	30	14	from	from	IN
cord-297178-moxhk2e0	30	15	immune	immune	JJ
cord-297178-moxhk2e0	30	16	response	response	NN
cord-297178-moxhk2e0	30	17	mediated	mediate	VBN
cord-297178-moxhk2e0	30	18	by	by	IN
cord-297178-moxhk2e0	30	19	human	human	JJ
cord-297178-moxhk2e0	30	20	ZAP	ZAP	NNP
cord-297178-moxhk2e0	30	21	(	(	-LRB-
cord-297178-moxhk2e0	30	22	zinc	zinc	NN
cord-297178-moxhk2e0	30	23	finger	finger	NN
cord-297178-moxhk2e0	30	24	antiviral	antiviral	JJ
cord-297178-moxhk2e0	30	25	protein	protein	NNP
cord-297178-moxhk2e0	30	26	)	)	-RRB-
cord-297178-moxhk2e0	30	27	,	,	,
cord-297178-moxhk2e0	30	28	thus	thus	RB
cord-297178-moxhk2e0	30	29	4	4	CD
cord-297178-moxhk2e0	30	30	becoming	become	VBG
cord-297178-moxhk2e0	30	31	a	a	DT
cord-297178-moxhk2e0	30	32	severe	severe	JJ
cord-297178-moxhk2e0	30	33	human	human	JJ
cord-297178-moxhk2e0	30	34	pathogen	pathogen	NN
cord-297178-moxhk2e0	30	35	[	[	-LRB-
cord-297178-moxhk2e0	30	36	24	24	CD
cord-297178-moxhk2e0	30	37	]	]	-RRB-
cord-297178-moxhk2e0	30	38	.	.	.
cord-297178-moxhk2e0	31	1	Furthermore	furthermore	RB
cord-297178-moxhk2e0	31	2	,	,	,
cord-297178-moxhk2e0	31	3	SARS	SARS	NNP
cord-297178-moxhk2e0	31	4	-	-	HYPH
cord-297178-moxhk2e0	31	5	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	31	6	has	have	VBZ
cord-297178-moxhk2e0	31	7	a	a	DT
cord-297178-moxhk2e0	31	8	much	much	RB
cord-297178-moxhk2e0	31	9	higher	high	JJR
cord-297178-moxhk2e0	31	10	infection	infection	NN
cord-297178-moxhk2e0	31	11	and	and	CC
cord-297178-moxhk2e0	31	12	replication	replication	NN
cord-297178-moxhk2e0	31	13	capacity	capacity	NN
cord-297178-moxhk2e0	31	14	than	than	IN
cord-297178-moxhk2e0	31	15	SARS	SARS	NNP
cord-297178-moxhk2e0	31	16	-	-	HYPH
cord-297178-moxhk2e0	31	17	CoV	CoV	NNP
cord-297178-moxhk2e0	31	18	,	,	,
cord-297178-moxhk2e0	31	19	however	however	RB
cord-297178-moxhk2e0	31	20	without	without	IN
cord-297178-moxhk2e0	31	21	inducing	induce	VBG
cord-297178-moxhk2e0	31	22	in	in	IN
cord-297178-moxhk2e0	31	23	a	a	DT
cord-297178-moxhk2e0	31	24	significant	significant	JJ
cord-297178-moxhk2e0	31	25	way	way	NN
cord-297178-moxhk2e0	31	26	the	the	DT
cord-297178-moxhk2e0	31	27	increase	increase	NN
cord-297178-moxhk2e0	31	28	in	in	IN
cord-297178-moxhk2e0	31	29	interferons	interferon	NNS
cord-297178-moxhk2e0	31	30	type	type	NN
cord-297178-moxhk2e0	31	31	I	i	NN
cord-297178-moxhk2e0	31	32	,	,	,
cord-297178-moxhk2e0	31	33	II	II	NNP
cord-297178-moxhk2e0	31	34	or	or	CC
cord-297178-moxhk2e0	31	35	III	III	NNP
cord-297178-moxhk2e0	31	36	,	,	,
cord-297178-moxhk2e0	31	37	and	and	CC
cord-297178-moxhk2e0	31	38	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	31	39	mediators	mediator	NNS
cord-297178-moxhk2e0	31	40	(	(	-LRB-
cord-297178-moxhk2e0	31	41	pro	pro	JJ
cord-297178-moxhk2e0	31	42	-	-	JJ
cord-297178-moxhk2e0	31	43	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	31	44	cytokines	cytokine	NNS
cord-297178-moxhk2e0	31	45	/	/	SYM
cord-297178-moxhk2e0	31	46	chemokines	chemokine	NNS
cord-297178-moxhk2e0	31	47	)	)	-RRB-
cord-297178-moxhk2e0	31	48	[	[	-LRB-
cord-297178-moxhk2e0	31	49	25	25	CD
cord-297178-moxhk2e0	31	50	]	]	-RRB-
cord-297178-moxhk2e0	31	51	.	.	.
cord-297178-moxhk2e0	32	1	Such	such	JJ
cord-297178-moxhk2e0	32	2	characteristics	characteristic	NNS
cord-297178-moxhk2e0	32	3	of	of	IN
cord-297178-moxhk2e0	32	4	SARS	SARS	NNP
cord-297178-moxhk2e0	32	5	-	-	HYPH
cord-297178-moxhk2e0	32	6	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	32	7	are	be	VBP
cord-297178-moxhk2e0	32	8	imperative	imperative	JJ
cord-297178-moxhk2e0	32	9	for	for	IN
cord-297178-moxhk2e0	32	10	the	the	DT
cord-297178-moxhk2e0	32	11	understanding	understanding	NN
cord-297178-moxhk2e0	32	12	of	of	IN
cord-297178-moxhk2e0	32	13	COVID-19	covid-19	JJ
cord-297178-moxhk2e0	32	14	pathophysiology	pathophysiology	NN
cord-297178-moxhk2e0	32	15	.	.	.
cord-297178-moxhk2e0	33	1	The	the	DT
cord-297178-moxhk2e0	33	2	high	high	JJ
cord-297178-moxhk2e0	33	3	replication	replication	NN
cord-297178-moxhk2e0	33	4	rate	rate	NN
cord-297178-moxhk2e0	33	5	associated	associate	VBN
cord-297178-moxhk2e0	33	6	with	with	IN
cord-297178-moxhk2e0	33	7	low	low	JJ
cord-297178-moxhk2e0	33	8	inflammation	inflammation	NN
cord-297178-moxhk2e0	33	9	leads	lead	VBZ
cord-297178-moxhk2e0	33	10	to	to	IN
cord-297178-moxhk2e0	33	11	the	the	DT
cord-297178-moxhk2e0	33	12	viral	viral	JJ
cord-297178-moxhk2e0	33	13	peak	peak	NN
cord-297178-moxhk2e0	33	14	even	even	RB
cord-297178-moxhk2e0	33	15	at	at	IN
cord-297178-moxhk2e0	33	16	the	the	DT
cord-297178-moxhk2e0	33	17	onset	onset	NN
cord-297178-moxhk2e0	33	18	of	of	IN
cord-297178-moxhk2e0	33	19	symptoms	symptom	NNS
cord-297178-moxhk2e0	33	20	,	,	,
cord-297178-moxhk2e0	33	21	which	which	WDT
cord-297178-moxhk2e0	33	22	makes	make	VBZ
cord-297178-moxhk2e0	33	23	early	early	JJ
cord-297178-moxhk2e0	33	24	disease	disease	NN
cord-297178-moxhk2e0	33	25	identification	identification	NN
cord-297178-moxhk2e0	33	26	difficult	difficult	JJ
cord-297178-moxhk2e0	33	27	,	,	,
cord-297178-moxhk2e0	33	28	and	and	CC
cord-297178-moxhk2e0	33	29	as	as	IN
cord-297178-moxhk2e0	33	30	a	a	DT
cord-297178-moxhk2e0	33	31	consequence	consequence	NN
cord-297178-moxhk2e0	33	32	,	,	,
cord-297178-moxhk2e0	33	33	makes	make	VBZ
cord-297178-moxhk2e0	33	34	treatment	treatment	NN
cord-297178-moxhk2e0	33	35	with	with	IN
cord-297178-moxhk2e0	33	36	antivirals	antiviral	NNS
cord-297178-moxhk2e0	33	37	ineffective	ineffective	JJ
cord-297178-moxhk2e0	33	38	because	because	IN
cord-297178-moxhk2e0	33	39	the	the	DT
cord-297178-moxhk2e0	33	40	effectiveness	effectiveness	NN
cord-297178-moxhk2e0	33	41	of	of	IN
cord-297178-moxhk2e0	33	42	their	-PRON-	PRP$
cord-297178-moxhk2e0	33	43	action	action	NN
cord-297178-moxhk2e0	33	44	occurs	occur	VBZ
cord-297178-moxhk2e0	33	45	during	during	IN
cord-297178-moxhk2e0	33	46	the	the	DT
cord-297178-moxhk2e0	33	47	rise	rise	NN
cord-297178-moxhk2e0	33	48	of	of	IN
cord-297178-moxhk2e0	33	49	the	the	DT
cord-297178-moxhk2e0	33	50	replication	replication	NN
cord-297178-moxhk2e0	33	51	curve	curve	NN
cord-297178-moxhk2e0	33	52	,	,	,
cord-297178-moxhk2e0	33	53	the	the	DT
cord-297178-moxhk2e0	33	54	most	most	RBS
cord-297178-moxhk2e0	33	55	recommended	recommend	VBN
cord-297178-moxhk2e0	33	56	phase	phase	NN
cord-297178-moxhk2e0	33	57	for	for	IN
cord-297178-moxhk2e0	33	58	such	such	JJ
cord-297178-moxhk2e0	33	59	medicine	medicine	NN
cord-297178-moxhk2e0	33	60	[	[	-LRB-
cord-297178-moxhk2e0	33	61	25	25	CD
cord-297178-moxhk2e0	33	62	]	]	-RRB-
cord-297178-moxhk2e0	33	63	.	.	.
cord-297178-moxhk2e0	34	1	Although	although	IN
cord-297178-moxhk2e0	34	2	SARS	SARS	NNP
cord-297178-moxhk2e0	34	3	-	-	HYPH
cord-297178-moxhk2e0	34	4	CoV	CoV	NNP
cord-297178-moxhk2e0	34	5	and	and	CC
cord-297178-moxhk2e0	34	6	SARS	SARS	NNP
cord-297178-moxhk2e0	34	7	-	-	HYPH
cord-297178-moxhk2e0	34	8	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	34	9	use	use	VBP
cord-297178-moxhk2e0	34	10	ACE2	ACE2	NNP
cord-297178-moxhk2e0	34	11	as	as	IN
cord-297178-moxhk2e0	34	12	cell	cell	NN
cord-297178-moxhk2e0	34	13	coupling	coupling	NN
cord-297178-moxhk2e0	34	14	receptor	receptor	NN
cord-297178-moxhk2e0	34	15	,	,	,
cord-297178-moxhk2e0	34	16	the	the	DT
cord-297178-moxhk2e0	34	17	pathogenic	pathogenic	JJ
cord-297178-moxhk2e0	34	18	characteristics	characteristic	NNS
cord-297178-moxhk2e0	34	19	of	of	IN
cord-297178-moxhk2e0	34	20	SARS	SARS	NNP
cord-297178-moxhk2e0	34	21	-	-	:
cord-297178-moxhk2e0	34	22	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	34	23	provide	provide	VBP
cord-297178-moxhk2e0	34	24	a	a	DT
cord-297178-moxhk2e0	34	25	great	great	JJ
cord-297178-moxhk2e0	34	26	difference	difference	NN
cord-297178-moxhk2e0	34	27	on	on	IN
cord-297178-moxhk2e0	34	28	disease	disease	NN
cord-297178-moxhk2e0	34	29	progression	progression	NN
cord-297178-moxhk2e0	34	30	,	,	,
cord-297178-moxhk2e0	34	31	as	as	IN
cord-297178-moxhk2e0	34	32	shown	show	VBN
cord-297178-moxhk2e0	34	33	in	in	IN
cord-297178-moxhk2e0	34	34	Figure	figure	NN
cord-297178-moxhk2e0	34	35	2	2	CD
cord-297178-moxhk2e0	34	36	.	.	.
cord-297178-moxhk2e0	35	1	ACE2	ACE2	NNP
cord-297178-moxhk2e0	35	2	is	be	VBZ
cord-297178-moxhk2e0	35	3	a	a	DT
cord-297178-moxhk2e0	35	4	fundamental	fundamental	JJ
cord-297178-moxhk2e0	35	5	piece	piece	NN
cord-297178-moxhk2e0	35	6	in	in	IN
cord-297178-moxhk2e0	35	7	the	the	DT
cord-297178-moxhk2e0	35	8	pathophysiology	pathophysiology	NN
cord-297178-moxhk2e0	35	9	of	of	IN
cord-297178-moxhk2e0	35	10	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	35	11	,	,	,
cord-297178-moxhk2e0	35	12	since	since	IN
cord-297178-moxhk2e0	35	13	the	the	DT
cord-297178-moxhk2e0	35	14	high	high	JJ
cord-297178-moxhk2e0	35	15	replication	replication	NN
cord-297178-moxhk2e0	35	16	capacity	capacity	NN
cord-297178-moxhk2e0	35	17	of	of	IN
cord-297178-moxhk2e0	35	18	SAR	SAR	NNP
cord-297178-moxhk2e0	35	19	-	-	HYPH
cord-297178-moxhk2e0	35	20	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	35	21	is	be	VBZ
cord-297178-moxhk2e0	35	22	directly	directly	RB
cord-297178-moxhk2e0	35	23	related	relate	VBN
cord-297178-moxhk2e0	35	24	to	to	IN
cord-297178-moxhk2e0	35	25	the	the	DT
cord-297178-moxhk2e0	35	26	coupling	coupling	NN
cord-297178-moxhk2e0	35	27	to	to	IN
cord-297178-moxhk2e0	35	28	ACE2	ACE2	NNP
cord-297178-moxhk2e0	35	29	and	and	CC
cord-297178-moxhk2e0	35	30	cell	cell	NN
cord-297178-moxhk2e0	35	31	infection	infection	NN
cord-297178-moxhk2e0	35	32	.	.	.
cord-297178-moxhk2e0	36	1	Studies	study	NNS
cord-297178-moxhk2e0	36	2	show	show	VBP
cord-297178-moxhk2e0	36	3	that	that	IN
cord-297178-moxhk2e0	36	4	the	the	DT
cord-297178-moxhk2e0	36	5	virus	virus	NN
cord-297178-moxhk2e0	36	6	causes	cause	VBZ
cord-297178-moxhk2e0	36	7	a	a	DT
cord-297178-moxhk2e0	36	8	reduction	reduction	NN
cord-297178-moxhk2e0	36	9	of	of	IN
cord-297178-moxhk2e0	36	10	ACE2	ACE2	NNP
cord-297178-moxhk2e0	36	11	in	in	IN
cord-297178-moxhk2e0	36	12	the	the	DT
cord-297178-moxhk2e0	36	13	infected	infected	JJ
cord-297178-moxhk2e0	36	14	organs	organ	NNS
cord-297178-moxhk2e0	36	15	[	[	-LRB-
cord-297178-moxhk2e0	36	16	26	26	CD
cord-297178-moxhk2e0	36	17	]	]	-RRB-
cord-297178-moxhk2e0	36	18	.	.	.
cord-297178-moxhk2e0	37	1	Therefore	therefore	RB
cord-297178-moxhk2e0	37	2	,	,	,
cord-297178-moxhk2e0	37	3	the	the	DT
cord-297178-moxhk2e0	37	4	higher	high	JJR
cord-297178-moxhk2e0	37	5	the	the	DT
cord-297178-moxhk2e0	37	6	amount	amount	NN
cord-297178-moxhk2e0	37	7	of	of	IN
cord-297178-moxhk2e0	37	8	virus	virus	NN
cord-297178-moxhk2e0	37	9	,	,	,
cord-297178-moxhk2e0	37	10	the	the	DT
cord-297178-moxhk2e0	37	11	higher	high	JJR
cord-297178-moxhk2e0	37	12	will	will	MD
cord-297178-moxhk2e0	37	13	be	be	VB
cord-297178-moxhk2e0	37	14	the	the	DT
cord-297178-moxhk2e0	37	15	use	use	NN
cord-297178-moxhk2e0	37	16	of	of	IN
cord-297178-moxhk2e0	37	17	ACE2	ACE2	NNP
cord-297178-moxhk2e0	37	18	by	by	IN
cord-297178-moxhk2e0	37	19	it	-PRON-	PRP
cord-297178-moxhk2e0	37	20	,	,	,
cord-297178-moxhk2e0	37	21	creating	create	VBG
cord-297178-moxhk2e0	37	22	an	an	DT
cord-297178-moxhk2e0	37	23	inverse	inverse	JJ
cord-297178-moxhk2e0	37	24	correlation	correlation	NN
cord-297178-moxhk2e0	37	25	between	between	IN
cord-297178-moxhk2e0	37	26	the	the	DT
cord-297178-moxhk2e0	37	27	amount	amount	NN
cord-297178-moxhk2e0	37	28	of	of	IN
cord-297178-moxhk2e0	37	29	SARS	SARS	NNP
cord-297178-moxhk2e0	37	30	-	-	HYPH
cord-297178-moxhk2e0	37	31	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	37	32	and	and	CC
cord-297178-moxhk2e0	37	33	ACE2	ACE2	NNP
cord-297178-moxhk2e0	37	34	.	.	.
cord-297178-moxhk2e0	38	1	At	at	IN
cord-297178-moxhk2e0	38	2	a	a	DT
cord-297178-moxhk2e0	38	3	certain	certain	JJ
cord-297178-moxhk2e0	38	4	time	time	NN
cord-297178-moxhk2e0	38	5	,	,	,
cord-297178-moxhk2e0	38	6	the	the	DT
cord-297178-moxhk2e0	38	7	constant	constant	JJ
cord-297178-moxhk2e0	38	8	and	and	CC
cord-297178-moxhk2e0	38	9	gradual	gradual	JJ
cord-297178-moxhk2e0	38	10	reduction	reduction	NN
cord-297178-moxhk2e0	38	11	of	of	IN
cord-297178-moxhk2e0	38	12	ACE2	ACE2	NNP
cord-297178-moxhk2e0	38	13	will	will	MD
cord-297178-moxhk2e0	38	14	cause	cause	VB
cord-297178-moxhk2e0	38	15	a	a	DT
cord-297178-moxhk2e0	38	16	RAS	RAS	NNP
cord-297178-moxhk2e0	38	17	imbalance	imbalance	NN
cord-297178-moxhk2e0	38	18	,	,	,
cord-297178-moxhk2e0	38	19	increasing	increase	VBG
cord-297178-moxhk2e0	38	20	the	the	DT
cord-297178-moxhk2e0	38	21	action	action	NN
cord-297178-moxhk2e0	38	22	of	of	IN
cord-297178-moxhk2e0	38	23	ACE	ace	NN
cord-297178-moxhk2e0	38	24	in	in	IN
cord-297178-moxhk2e0	38	25	detriment	detriment	NN
cord-297178-moxhk2e0	38	26	of	of	IN
cord-297178-moxhk2e0	38	27	the	the	DT
cord-297178-moxhk2e0	38	28	decrease	decrease	NN
cord-297178-moxhk2e0	38	29	in	in	IN
cord-297178-moxhk2e0	38	30	the	the	DT
cord-297178-moxhk2e0	38	31	action	action	NN
cord-297178-moxhk2e0	38	32	of	of	IN
cord-297178-moxhk2e0	38	33	ACE2	ACE2	NNP
cord-297178-moxhk2e0	38	34	,	,	,
cord-297178-moxhk2e0	38	35	thus	thus	RB
cord-297178-moxhk2e0	38	36	prevailing	prevail	VBG
cord-297178-moxhk2e0	38	37	the	the	DT
cord-297178-moxhk2e0	38	38	harmful	harmful	JJ
cord-297178-moxhk2e0	38	39	factors	factor	NNS
cord-297178-moxhk2e0	38	40	(	(	-LRB-
cord-297178-moxhk2e0	38	41	Figure	figure	NN
cord-297178-moxhk2e0	38	42	3	3	CD
cord-297178-moxhk2e0	38	43	)	)	-RRB-
cord-297178-moxhk2e0	38	44	.	.	.
cord-297178-moxhk2e0	39	1	The	the	DT
cord-297178-moxhk2e0	39	2	ACE2	ACE2	NNP
cord-297178-moxhk2e0	39	3	level	level	NN
cord-297178-moxhk2e0	39	4	reduction	reduction	NN
cord-297178-moxhk2e0	39	5	caused	cause	VBN
cord-297178-moxhk2e0	39	6	by	by	IN
cord-297178-moxhk2e0	39	7	SARS	SARS	NNP
cord-297178-moxhk2e0	39	8	-	-	HYPH
cord-297178-moxhk2e0	39	9	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	39	10	infection	infection	NN
cord-297178-moxhk2e0	39	11	may	may	MD
cord-297178-moxhk2e0	39	12	be	be	VB
cord-297178-moxhk2e0	39	13	directly	directly	RB
cord-297178-moxhk2e0	39	14	related	relate	VBN
cord-297178-moxhk2e0	39	15	to	to	IN
cord-297178-moxhk2e0	39	16	the	the	DT
cord-297178-moxhk2e0	39	17	pathogenesis	pathogenesis	NN
cord-297178-moxhk2e0	39	18	of	of	IN
cord-297178-moxhk2e0	39	19	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	39	20	[	[	-LRB-
cord-297178-moxhk2e0	39	21	26	26	CD
cord-297178-moxhk2e0	39	22	]	]	-RRB-
cord-297178-moxhk2e0	39	23	.	.	.
cord-297178-moxhk2e0	40	1	The	the	DT
cord-297178-moxhk2e0	40	2	Ang	Ang	NNP
cord-297178-moxhk2e0	40	3	1	1	CD
cord-297178-moxhk2e0	40	4	-	-	SYM
cord-297178-moxhk2e0	40	5	7	7	CD
cord-297178-moxhk2e0	40	6	decrease	decrease	NN
cord-297178-moxhk2e0	40	7	and	and	CC
cord-297178-moxhk2e0	40	8	the	the	DT
cord-297178-moxhk2e0	40	9	lower	low	JJR
cord-297178-moxhk2e0	40	10	activation	activation	NN
cord-297178-moxhk2e0	40	11	of	of	IN
cord-297178-moxhk2e0	40	12	Mas	Mas	NNP
cord-297178-moxhk2e0	40	13	receptors	receptor	NNS
cord-297178-moxhk2e0	40	14	and	and	CC
cord-297178-moxhk2e0	40	15	/	/	SYM
cord-297178-moxhk2e0	40	16	or	or	CC
cord-297178-moxhk2e0	40	17	the	the	DT
cord-297178-moxhk2e0	40	18	Ang	Ang	NNP
cord-297178-moxhk2e0	40	19	II	II	NNP
cord-297178-moxhk2e0	40	20	production	production	NN
cord-297178-moxhk2e0	40	21	increase	increase	NN
cord-297178-moxhk2e0	40	22	,	,	,
cord-297178-moxhk2e0	40	23	with	with	IN
cord-297178-moxhk2e0	40	24	5	5	CD
cord-297178-moxhk2e0	40	25	subsequent	subsequent	JJ
cord-297178-moxhk2e0	40	26	activation	activation	NN
cord-297178-moxhk2e0	40	27	of	of	IN
cord-297178-moxhk2e0	40	28	AT1	AT1	NNP
cord-297178-moxhk2e0	40	29	receptor	receptor	NN
cord-297178-moxhk2e0	40	30	,	,	,
cord-297178-moxhk2e0	40	31	is	be	VBZ
cord-297178-moxhk2e0	40	32	widely	widely	RB
cord-297178-moxhk2e0	40	33	known	know	VBN
cord-297178-moxhk2e0	40	34	for	for	IN
cord-297178-moxhk2e0	40	35	the	the	DT
cord-297178-moxhk2e0	40	36	triggering	triggering	NN
cord-297178-moxhk2e0	40	37	of	of	IN
cord-297178-moxhk2e0	40	38	inflammation	inflammation	NN
cord-297178-moxhk2e0	40	39	and	and	CC
cord-297178-moxhk2e0	40	40	fibrosis	fibrosis	NN
cord-297178-moxhk2e0	40	41	[	[	-LRB-
cord-297178-moxhk2e0	40	42	27	27	CD
cord-297178-moxhk2e0	40	43	]	]	-RRB-
cord-297178-moxhk2e0	40	44	.	.	.
cord-297178-moxhk2e0	41	1	For	for	IN
cord-297178-moxhk2e0	41	2	example	example	NN
cord-297178-moxhk2e0	41	3	,	,	,
cord-297178-moxhk2e0	41	4	a	a	DT
cord-297178-moxhk2e0	41	5	study	study	NN
cord-297178-moxhk2e0	41	6	with	with	IN
cord-297178-moxhk2e0	41	7	mice	mouse	NNS
cord-297178-moxhk2e0	41	8	has	have	VBZ
cord-297178-moxhk2e0	41	9	shown	show	VBN
cord-297178-moxhk2e0	41	10	that	that	IN
cord-297178-moxhk2e0	41	11	acute	acute	JJ
cord-297178-moxhk2e0	41	12	lung	lung	NN
cord-297178-moxhk2e0	41	13	lesion	lesion	NN
cord-297178-moxhk2e0	41	14	results	result	VBZ
cord-297178-moxhk2e0	41	15	in	in	IN
cord-297178-moxhk2e0	41	16	a	a	DT
cord-297178-moxhk2e0	41	17	marked	marked	JJ
cord-297178-moxhk2e0	41	18	decrease	decrease	NN
cord-297178-moxhk2e0	41	19	of	of	IN
cord-297178-moxhk2e0	41	20	ACE2	ACE2	NNP
cord-297178-moxhk2e0	41	21	,	,	,
cord-297178-moxhk2e0	41	22	and	and	CC
cord-297178-moxhk2e0	41	23	the	the	DT
cord-297178-moxhk2e0	41	24	use	use	NN
cord-297178-moxhk2e0	41	25	of	of	IN
cord-297178-moxhk2e0	41	26	recombinant	recombinant	JJ
cord-297178-moxhk2e0	41	27	ACE2	ACE2	NNP
cord-297178-moxhk2e0	41	28	has	have	VBZ
cord-297178-moxhk2e0	41	29	a	a	DT
cord-297178-moxhk2e0	41	30	protective	protective	JJ
cord-297178-moxhk2e0	41	31	effect	effect	NN
cord-297178-moxhk2e0	41	32	against	against	IN
cord-297178-moxhk2e0	41	33	the	the	DT
cord-297178-moxhk2e0	41	34	lung	lung	NN
cord-297178-moxhk2e0	41	35	lesion	lesion	NN
cord-297178-moxhk2e0	41	36	.	.	.
cord-297178-moxhk2e0	42	1	The	the	DT
cord-297178-moxhk2e0	42	2	same	same	JJ
cord-297178-moxhk2e0	42	3	study	study	NN
cord-297178-moxhk2e0	42	4	noted	note	VBD
cord-297178-moxhk2e0	42	5	that	that	IN
cord-297178-moxhk2e0	42	6	ACE2	ACE2	NNP
cord-297178-moxhk2e0	42	7	,	,	,
cord-297178-moxhk2e0	42	8	Ang	Ang	NNP
cord-297178-moxhk2e0	42	9	II	II	NNP
cord-297178-moxhk2e0	42	10	,	,	,
cord-297178-moxhk2e0	42	11	and	and	CC
cord-297178-moxhk2e0	42	12	the	the	DT
cord-297178-moxhk2e0	42	13	Ang	Ang	NNP
cord-297178-moxhk2e0	42	14	II	II	NNP
cord-297178-moxhk2e0	42	15	receptor	receptor	NN
cord-297178-moxhk2e0	42	16	1	1	CD
cord-297178-moxhk2e0	43	1	(	(	-LRB-
cord-297178-moxhk2e0	43	2	AT1	AT1	NNP
cord-297178-moxhk2e0	43	3	)	)	-RRB-
cord-297178-moxhk2e0	43	4	provoke	provoke	VB
cord-297178-moxhk2e0	43	5	the	the	DT
cord-297178-moxhk2e0	43	6	disease	disease	NN
cord-297178-moxhk2e0	43	7	pathogenesis	pathogenesis	NN
cord-297178-moxhk2e0	43	8	.	.	.
cord-297178-moxhk2e0	44	1	Thus	thus	RB
cord-297178-moxhk2e0	44	2	,	,	,
cord-297178-moxhk2e0	44	3	the	the	DT
cord-297178-moxhk2e0	44	4	important	important	JJ
cord-297178-moxhk2e0	44	5	role	role	NN
cord-297178-moxhk2e0	44	6	of	of	IN
cord-297178-moxhk2e0	44	7	RAS	RAS	NNP
cord-297178-moxhk2e0	44	8	on	on	IN
cord-297178-moxhk2e0	44	9	acute	acute	JJ
cord-297178-moxhk2e0	44	10	lung	lung	NN
cord-297178-moxhk2e0	44	11	lesion	lesion	NN
cord-297178-moxhk2e0	44	12	pathogenesis	pathogenesis	NN
cord-297178-moxhk2e0	44	13	is	be	VBZ
cord-297178-moxhk2e0	44	14	demonstrated	demonstrate	VBN
cord-297178-moxhk2e0	44	15	[	[	-LRB-
cord-297178-moxhk2e0	44	16	28	28	CD
cord-297178-moxhk2e0	44	17	]	]	-RRB-
cord-297178-moxhk2e0	44	18	.	.	.
cord-297178-moxhk2e0	45	1	Histologically	histologically	RB
cord-297178-moxhk2e0	45	2	,	,	,
cord-297178-moxhk2e0	45	3	patients	patient	NNS
cord-297178-moxhk2e0	45	4	with	with	IN
cord-297178-moxhk2e0	45	5	COVID-19	covid-19	DT
cord-297178-moxhk2e0	45	6	present	present	JJ
cord-297178-moxhk2e0	45	7	a	a	DT
cord-297178-moxhk2e0	45	8	pattern	pattern	NN
cord-297178-moxhk2e0	45	9	of	of	IN
cord-297178-moxhk2e0	45	10	diffuse	diffuse	JJ
cord-297178-moxhk2e0	45	11	alveolar	alveolar	NN
cord-297178-moxhk2e0	45	12	damage	damage	NN
cord-297178-moxhk2e0	45	13	and	and	CC
cord-297178-moxhk2e0	45	14	perivascular	perivascular	JJ
cord-297178-moxhk2e0	45	15	lymphocyte	lymphocyte	NN
cord-297178-moxhk2e0	45	16	infiltration	infiltration	NN
cord-297178-moxhk2e0	45	17	,	,	,
cord-297178-moxhk2e0	45	18	similar	similar	JJ
cord-297178-moxhk2e0	45	19	to	to	IN
cord-297178-moxhk2e0	45	20	what	what	WP
cord-297178-moxhk2e0	45	21	is	be	VBZ
cord-297178-moxhk2e0	45	22	observed	observe	VBN
cord-297178-moxhk2e0	45	23	in	in	IN
cord-297178-moxhk2e0	45	24	influenza	influenza	NN
cord-297178-moxhk2e0	45	25	cases	case	NNS
cord-297178-moxhk2e0	45	26	.	.	.
cord-297178-moxhk2e0	46	1	A	a	DT
cord-297178-moxhk2e0	46	2	surprising	surprising	JJ
cord-297178-moxhk2e0	46	3	histopathological	histopathological	JJ
cord-297178-moxhk2e0	46	4	finding	finding	NN
cord-297178-moxhk2e0	46	5	on	on	IN
cord-297178-moxhk2e0	46	6	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	46	7	was	be	VBD
cord-297178-moxhk2e0	46	8	the	the	DT
cord-297178-moxhk2e0	46	9	lung	lung	NN
cord-297178-moxhk2e0	46	10	angiogenesis	angiogenesis	NN
cord-297178-moxhk2e0	46	11	,	,	,
cord-297178-moxhk2e0	46	12	which	which	WDT
cord-297178-moxhk2e0	46	13	is	be	VBZ
cord-297178-moxhk2e0	46	14	2.7	2.7	CD
cord-297178-moxhk2e0	46	15	times	time	NNS
cord-297178-moxhk2e0	46	16	greater	great	JJR
cord-297178-moxhk2e0	46	17	than	than	IN
cord-297178-moxhk2e0	46	18	on	on	IN
cord-297178-moxhk2e0	46	19	the	the	DT
cord-297178-moxhk2e0	46	20	lungs	lung	NNS
cord-297178-moxhk2e0	46	21	of	of	IN
cord-297178-moxhk2e0	46	22	patients	patient	NNS
cord-297178-moxhk2e0	46	23	with	with	IN
cord-297178-moxhk2e0	46	24	influenza	influenza	NN
cord-297178-moxhk2e0	46	25	[	[	-LRB-
cord-297178-moxhk2e0	46	26	29	29	CD
cord-297178-moxhk2e0	46	27	]	]	-RRB-
cord-297178-moxhk2e0	46	28	.	.	.
cord-297178-moxhk2e0	47	1	Angiogenesis	Angiogenesis	NNP
cord-297178-moxhk2e0	47	2	,	,	,
cord-297178-moxhk2e0	47	3	a	a	DT
cord-297178-moxhk2e0	47	4	complex	complex	JJ
cord-297178-moxhk2e0	47	5	process	process	NN
cord-297178-moxhk2e0	47	6	by	by	IN
cord-297178-moxhk2e0	47	7	which	which	WDT
cord-297178-moxhk2e0	47	8	new	new	JJ
cord-297178-moxhk2e0	47	9	blood	blood	NN
cord-297178-moxhk2e0	47	10	vessels	vessel	NNS
cord-297178-moxhk2e0	47	11	are	be	VBP
cord-297178-moxhk2e0	47	12	formed	form	VBN
cord-297178-moxhk2e0	47	13	from	from	IN
cord-297178-moxhk2e0	47	14	existing	exist	VBG
cord-297178-moxhk2e0	47	15	,	,	,
cord-297178-moxhk2e0	47	16	is	be	VBZ
cord-297178-moxhk2e0	47	17	induced	induce	VBN
cord-297178-moxhk2e0	47	18	by	by	IN
cord-297178-moxhk2e0	47	19	hypoxia	hypoxia	NN
cord-297178-moxhk2e0	47	20	.	.	.
cord-297178-moxhk2e0	48	1	Hypoxia	hypoxia	NN
cord-297178-moxhk2e0	48	2	is	be	VBZ
cord-297178-moxhk2e0	48	3	a	a	DT
cord-297178-moxhk2e0	48	4	condition	condition	NN
cord-297178-moxhk2e0	48	5	in	in	IN
cord-297178-moxhk2e0	48	6	which	which	WDT
cord-297178-moxhk2e0	48	7	tissues	tissue	NNS
cord-297178-moxhk2e0	48	8	are	be	VBP
cord-297178-moxhk2e0	48	9	not	not	RB
cord-297178-moxhk2e0	48	10	properly	properly	RB
cord-297178-moxhk2e0	48	11	oxygenated	oxygenated	JJ
cord-297178-moxhk2e0	48	12	,	,	,
cord-297178-moxhk2e0	48	13	resulting	result	VBG
cord-297178-moxhk2e0	48	14	in	in	IN
cord-297178-moxhk2e0	48	15	considerable	considerable	JJ
cord-297178-moxhk2e0	48	16	cell	cell	NN
cord-297178-moxhk2e0	48	17	stress	stress	NN
cord-297178-moxhk2e0	48	18	and	and	CC
cord-297178-moxhk2e0	48	19	adaptive	adaptive	JJ
cord-297178-moxhk2e0	48	20	responses	response	NNS
cord-297178-moxhk2e0	48	21	.	.	.
cord-297178-moxhk2e0	49	1	The	the	DT
cord-297178-moxhk2e0	49	2	transcriptional	transcriptional	JJ
cord-297178-moxhk2e0	49	3	responses	response	NNS
cord-297178-moxhk2e0	49	4	to	to	IN
cord-297178-moxhk2e0	49	5	hypoxia	hypoxia	NN
cord-297178-moxhk2e0	49	6	are	be	VBP
cord-297178-moxhk2e0	49	7	mostly	mostly	RB
cord-297178-moxhk2e0	49	8	mediated	mediate	VBN
cord-297178-moxhk2e0	49	9	by	by	IN
cord-297178-moxhk2e0	49	10	the	the	DT
cord-297178-moxhk2e0	49	11	hypoxiainducible	hypoxiainducible	JJ
cord-297178-moxhk2e0	49	12	factor	factor	NN
cord-297178-moxhk2e0	49	13	(	(	-LRB-
cord-297178-moxhk2e0	49	14	HIF	HIF	NNP
cord-297178-moxhk2e0	49	15	)	)	-RRB-
cord-297178-moxhk2e0	49	16	,	,	,
cord-297178-moxhk2e0	49	17	a	a	DT
cord-297178-moxhk2e0	49	18	transcription	transcription	NN
cord-297178-moxhk2e0	49	19	factor	factor	NN
cord-297178-moxhk2e0	49	20	that	that	WDT
cord-297178-moxhk2e0	49	21	acts	act	VBZ
cord-297178-moxhk2e0	49	22	as	as	IN
cord-297178-moxhk2e0	49	23	oxygen	oxygen	NN
cord-297178-moxhk2e0	49	24	sensors	sensor	NNS
cord-297178-moxhk2e0	49	25	and	and	CC
cord-297178-moxhk2e0	49	26	are	be	VBP
cord-297178-moxhk2e0	49	27	related	relate	VBN
cord-297178-moxhk2e0	49	28	to	to	IN
cord-297178-moxhk2e0	49	29	the	the	DT
cord-297178-moxhk2e0	49	30	activation	activation	NN
cord-297178-moxhk2e0	49	31	of	of	IN
cord-297178-moxhk2e0	49	32	VEGF	VEGF	NNP
cord-297178-moxhk2e0	49	33	-	-	:
cord-297178-moxhk2e0	49	34	A	a	DT
cord-297178-moxhk2e0	49	35	expression	expression	NN
cord-297178-moxhk2e0	49	36	[	[	-LRB-
cord-297178-moxhk2e0	49	37	30	30	CD
cord-297178-moxhk2e0	49	38	,	,	,
cord-297178-moxhk2e0	49	39	31	31	CD
cord-297178-moxhk2e0	49	40	]	]	-RRB-
cord-297178-moxhk2e0	49	41	.	.	.
cord-297178-moxhk2e0	50	1	Under	under	IN
cord-297178-moxhk2e0	50	2	hypoxia	hypoxia	NN
cord-297178-moxhk2e0	50	3	,	,	,
cord-297178-moxhk2e0	50	4	HIF	HIF	NNP
cord-297178-moxhk2e0	50	5	influences	influence	VBZ
cord-297178-moxhk2e0	50	6	ACE	ACE	NNP
cord-297178-moxhk2e0	50	7	and	and	CC
cord-297178-moxhk2e0	50	8	ACE2	ACE2	NNP
cord-297178-moxhk2e0	50	9	in	in	IN
cord-297178-moxhk2e0	50	10	different	different	JJ
cord-297178-moxhk2e0	50	11	ways	way	NNS
cord-297178-moxhk2e0	50	12	,	,	,
cord-297178-moxhk2e0	50	13	positively	positively	RB
cord-297178-moxhk2e0	50	14	regulating	regulate	VBG
cord-297178-moxhk2e0	50	15	the	the	DT
cord-297178-moxhk2e0	50	16	expression	expression	NN
cord-297178-moxhk2e0	50	17	of	of	IN
cord-297178-moxhk2e0	50	18	ACE	ace	NN
cord-297178-moxhk2e0	50	19	and	and	CC
cord-297178-moxhk2e0	50	20	negatively	negatively	RB
cord-297178-moxhk2e0	50	21	of	of	IN
cord-297178-moxhk2e0	50	22	ACE2	ACE2	NNP
cord-297178-moxhk2e0	50	23	[	[	-LRB-
cord-297178-moxhk2e0	50	24	32	32	CD
cord-297178-moxhk2e0	50	25	,	,	,
cord-297178-moxhk2e0	50	26	33	33	CD
cord-297178-moxhk2e0	50	27	]	]	-RRB-
cord-297178-moxhk2e0	50	28	.	.	.
cord-297178-moxhk2e0	51	1	In	in	IN
cord-297178-moxhk2e0	51	2	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	51	3	,	,	,
cord-297178-moxhk2e0	51	4	such	such	JJ
cord-297178-moxhk2e0	51	5	circumstances	circumstance	NNS
cord-297178-moxhk2e0	51	6	may	may	MD
cord-297178-moxhk2e0	51	7	worsen	worsen	VB
cord-297178-moxhk2e0	51	8	the	the	DT
cord-297178-moxhk2e0	51	9	clinical	clinical	JJ
cord-297178-moxhk2e0	51	10	condition	condition	NN
cord-297178-moxhk2e0	51	11	,	,	,
cord-297178-moxhk2e0	51	12	for	for	IN
cord-297178-moxhk2e0	51	13	stimulating	stimulate	VBG
cord-297178-moxhk2e0	51	14	even	even	RB
cord-297178-moxhk2e0	51	15	more	more	RBR
cord-297178-moxhk2e0	51	16	the	the	DT
cord-297178-moxhk2e0	51	17	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	51	18	,	,	,
cord-297178-moxhk2e0	51	19	fibrotic	fibrotic	JJ
cord-297178-moxhk2e0	51	20	,	,	,
cord-297178-moxhk2e0	51	21	and	and	CC
cord-297178-moxhk2e0	51	22	thrombogenic	thrombogenic	JJ
cord-297178-moxhk2e0	51	23	pathways	pathway	NNS
cord-297178-moxhk2e0	51	24	of	of	IN
cord-297178-moxhk2e0	51	25	RAS	RAS	NNP
cord-297178-moxhk2e0	51	26	.	.	.
cord-297178-moxhk2e0	52	1	Although	although	IN
cord-297178-moxhk2e0	52	2	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	52	3	is	be	VBZ
cord-297178-moxhk2e0	52	4	clinically	clinically	RB
cord-297178-moxhk2e0	52	5	classified	classify	VBN
cord-297178-moxhk2e0	52	6	as	as	IN
cord-297178-moxhk2e0	52	7	an	an	DT
cord-297178-moxhk2e0	52	8	acute	acute	JJ
cord-297178-moxhk2e0	52	9	respiratory	respiratory	JJ
cord-297178-moxhk2e0	52	10	syndrome	syndrome	NN
cord-297178-moxhk2e0	52	11	,	,	,
cord-297178-moxhk2e0	52	12	the	the	DT
cord-297178-moxhk2e0	52	13	increased	increase	VBN
cord-297178-moxhk2e0	52	14	angiogenesis	angiogenesis	NN
cord-297178-moxhk2e0	52	15	suggests	suggest	VBZ
cord-297178-moxhk2e0	52	16	a	a	DT
cord-297178-moxhk2e0	52	17	chronic	chronic	JJ
cord-297178-moxhk2e0	52	18	cell	cell	NN
cord-297178-moxhk2e0	52	19	adaptation	adaptation	NN
cord-297178-moxhk2e0	52	20	towards	towards	IN
cord-297178-moxhk2e0	52	21	progressive	progressive	JJ
cord-297178-moxhk2e0	52	22	hypoxia	hypoxia	NN
cord-297178-moxhk2e0	52	23	.	.	.
cord-297178-moxhk2e0	53	1	The	the	DT
cord-297178-moxhk2e0	53	2	chronic	chronic	JJ
cord-297178-moxhk2e0	53	3	adaptation	adaptation	NN
cord-297178-moxhk2e0	53	4	to	to	IN
cord-297178-moxhk2e0	53	5	hypoxia	hypoxia	NN
cord-297178-moxhk2e0	53	6	could	could	MD
cord-297178-moxhk2e0	53	7	explain	explain	VB
cord-297178-moxhk2e0	53	8	the	the	DT
cord-297178-moxhk2e0	53	9	higher	high	JJR
cord-297178-moxhk2e0	53	10	resistance	resistance	NN
cord-297178-moxhk2e0	53	11	of	of	IN
cord-297178-moxhk2e0	53	12	some	some	DT
cord-297178-moxhk2e0	53	13	patients	patient	NNS
cord-297178-moxhk2e0	53	14	towards	towards	IN
cord-297178-moxhk2e0	53	15	low	low	JJ
cord-297178-moxhk2e0	53	16	O2	o2	NN
cord-297178-moxhk2e0	53	17	saturation	saturation	NN
cord-297178-moxhk2e0	53	18	,	,	,
cord-297178-moxhk2e0	53	19	in	in	IN
cord-297178-moxhk2e0	53	20	which	which	WDT
cord-297178-moxhk2e0	53	21	such	such	JJ
cord-297178-moxhk2e0	53	22	patients	patient	NNS
cord-297178-moxhk2e0	53	23	do	do	VBP
cord-297178-moxhk2e0	53	24	not	not	RB
cord-297178-moxhk2e0	53	25	present	present	VB
cord-297178-moxhk2e0	53	26	an	an	DT
cord-297178-moxhk2e0	53	27	involuntary	involuntary	JJ
cord-297178-moxhk2e0	53	28	increase	increase	NN
cord-297178-moxhk2e0	53	29	of	of	IN
cord-297178-moxhk2e0	53	30	ventilation	ventilation	NN
cord-297178-moxhk2e0	53	31	,	,	,
cord-297178-moxhk2e0	53	32	even	even	RB
cord-297178-moxhk2e0	53	33	when	when	WRB
cord-297178-moxhk2e0	53	34	great	great	JJ
cord-297178-moxhk2e0	53	35	lung	lung	NN
cord-297178-moxhk2e0	53	36	damage	damage	NN
cord-297178-moxhk2e0	53	37	is	be	VBZ
cord-297178-moxhk2e0	53	38	present	present	JJ
cord-297178-moxhk2e0	53	39	(	(	-LRB-
cord-297178-moxhk2e0	53	40	"	"	``
cord-297178-moxhk2e0	53	41	ground	ground	NN
cord-297178-moxhk2e0	53	42	-	-	HYPH
cord-297178-moxhk2e0	53	43	glass	glass	NN
cord-297178-moxhk2e0	53	44	opacity	opacity	NN
cord-297178-moxhk2e0	53	45	"	"	''
cord-297178-moxhk2e0	53	46	)	)	-RRB-
cord-297178-moxhk2e0	53	47	.	.	.
cord-297178-moxhk2e0	54	1	The	the	DT
cord-297178-moxhk2e0	54	2	replicative	replicative	JJ
cord-297178-moxhk2e0	54	3	cycle	cycle	NN
cord-297178-moxhk2e0	54	4	of	of	IN
cord-297178-moxhk2e0	54	5	SARS	SARS	NNP
cord-297178-moxhk2e0	54	6	-	-	HYPH
cord-297178-moxhk2e0	54	7	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	54	8	causes	cause	VBZ
cord-297178-moxhk2e0	54	9	a	a	DT
cord-297178-moxhk2e0	54	10	local	local	JJ
cord-297178-moxhk2e0	54	11	immune	immune	JJ
cord-297178-moxhk2e0	54	12	response	response	NN
cord-297178-moxhk2e0	54	13	as	as	IN
cord-297178-moxhk2e0	54	14	a	a	DT
cord-297178-moxhk2e0	54	15	result	result	NN
cord-297178-moxhk2e0	54	16	of	of	IN
cord-297178-moxhk2e0	54	17	cell	cell	NN
cord-297178-moxhk2e0	54	18	death	death	NN
cord-297178-moxhk2e0	54	19	and	and	CC
cord-297178-moxhk2e0	54	20	tissue	tissue	NN
cord-297178-moxhk2e0	54	21	damage	damage	NN
cord-297178-moxhk2e0	54	22	.	.	.
cord-297178-moxhk2e0	55	1	In	in	IN
cord-297178-moxhk2e0	55	2	some	some	DT
cord-297178-moxhk2e0	55	3	cases	case	NNS
cord-297178-moxhk2e0	55	4	,	,	,
cord-297178-moxhk2e0	55	5	the	the	DT
cord-297178-moxhk2e0	55	6	immune	immune	JJ
cord-297178-moxhk2e0	55	7	response	response	NN
cord-297178-moxhk2e0	55	8	occurs	occur	VBZ
cord-297178-moxhk2e0	55	9	in	in	IN
cord-297178-moxhk2e0	55	10	an	an	DT
cord-297178-moxhk2e0	55	11	unregulated	unregulated	JJ
cord-297178-moxhk2e0	55	12	manner	manner	NN
cord-297178-moxhk2e0	55	13	,	,	,
cord-297178-moxhk2e0	55	14	triggering	trigger	VBG
cord-297178-moxhk2e0	55	15	a	a	DT
cord-297178-moxhk2e0	55	16	cytokine	cytokine	NN
cord-297178-moxhk2e0	55	17	storm	storm	NN
cord-297178-moxhk2e0	55	18	,	,	,
cord-297178-moxhk2e0	55	19	and	and	CC
cord-297178-moxhk2e0	55	20	consequently	consequently	RB
cord-297178-moxhk2e0	55	21	,	,	,
cord-297178-moxhk2e0	55	22	generalized	generalize	VBN
cord-297178-moxhk2e0	55	23	pulmonary	pulmonary	JJ
cord-297178-moxhk2e0	55	24	inflammation	inflammation	NN
cord-297178-moxhk2e0	55	25	[	[	-LRB-
cord-297178-moxhk2e0	55	26	34	34	CD
cord-297178-moxhk2e0	55	27	]	]	-RRB-
cord-297178-moxhk2e0	55	28	.	.	.
cord-297178-moxhk2e0	56	1	As	as	IN
cord-297178-moxhk2e0	56	2	with	with	IN
cord-297178-moxhk2e0	56	3	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	56	4	,	,	,
cord-297178-moxhk2e0	56	5	other	other	JJ
cord-297178-moxhk2e0	56	6	acute	acute	JJ
cord-297178-moxhk2e0	56	7	respiratory	respiratory	JJ
cord-297178-moxhk2e0	56	8	diseases	disease	NNS
cord-297178-moxhk2e0	56	9	(	(	-LRB-
cord-297178-moxhk2e0	56	10	SARS	SARS	NNP
cord-297178-moxhk2e0	56	11	,	,	,
cord-297178-moxhk2e0	56	12	MERS	MERS	NNP
cord-297178-moxhk2e0	56	13	,	,	,
cord-297178-moxhk2e0	56	14	Influenza	Influenza	NNP
cord-297178-moxhk2e0	56	15	)	)	-RRB-
cord-297178-moxhk2e0	56	16	can	can	MD
cord-297178-moxhk2e0	56	17	also	also	RB
cord-297178-moxhk2e0	56	18	present	present	VB
cord-297178-moxhk2e0	56	19	the	the	DT
cord-297178-moxhk2e0	56	20	clinical	clinical	JJ
cord-297178-moxhk2e0	56	21	picture	picture	NN
cord-297178-moxhk2e0	56	22	of	of	IN
cord-297178-moxhk2e0	56	23	cytokine	cytokine	NN
cord-297178-moxhk2e0	56	24	storm	storm	NN
cord-297178-moxhk2e0	56	25	[	[	-LRB-
cord-297178-moxhk2e0	56	26	35	35	CD
cord-297178-moxhk2e0	56	27	]	]	-RRB-
cord-297178-moxhk2e0	56	28	.	.	.
cord-297178-moxhk2e0	57	1	High	high	JJ
cord-297178-moxhk2e0	57	2	virus	virus	NN
cord-297178-moxhk2e0	57	3	titers	titer	NNS
cord-297178-moxhk2e0	57	4	and	and	CC
cord-297178-moxhk2e0	57	5	dysregulation	dysregulation	NN
cord-297178-moxhk2e0	57	6	of	of	IN
cord-297178-moxhk2e0	57	7	the	the	DT
cord-297178-moxhk2e0	57	8	cytokine	cytokine	NN
cord-297178-moxhk2e0	57	9	/	/	SYM
cord-297178-moxhk2e0	57	10	chemokine	chemokine	NN
cord-297178-moxhk2e0	57	11	response	response	NN
cord-297178-moxhk2e0	57	12	cause	cause	VBP
cord-297178-moxhk2e0	57	13	an	an	DT
cord-297178-moxhk2e0	57	14	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	57	15	cytokine	cytokine	NN
cord-297178-moxhk2e0	57	16	storm	storm	NN
cord-297178-moxhk2e0	57	17	,	,	,
cord-297178-moxhk2e0	57	18	mainly	mainly	RB
cord-297178-moxhk2e0	57	19	related	relate	VBN
cord-297178-moxhk2e0	57	20	to	to	IN
cord-297178-moxhk2e0	57	21	the	the	DT
cord-297178-moxhk2e0	57	22	influx	influx	NN
cord-297178-moxhk2e0	57	23	of	of	IN
cord-297178-moxhk2e0	57	24	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	57	25	mononuclear	mononuclear	JJ
cord-297178-moxhk2e0	57	26	macrophages	macrophage	NNS
cord-297178-moxhk2e0	57	27	.	.	.
cord-297178-moxhk2e0	58	1	The	the	DT
cord-297178-moxhk2e0	58	2	activation	activation	NN
cord-297178-moxhk2e0	58	3	of	of	IN
cord-297178-moxhk2e0	58	4	these	these	DT
cord-297178-moxhk2e0	58	5	macrophages	macrophage	NNS
cord-297178-moxhk2e0	58	6	by	by	IN
cord-297178-moxhk2e0	58	7	interferon	interferon	NN
cord-297178-moxhk2e0	58	8	-	-	HYPH
cord-297178-moxhk2e0	58	9	α	α	NNP
cord-297178-moxhk2e0	58	10	/	/	SYM
cord-297178-moxhk2e0	58	11	β	β	NN
cord-297178-moxhk2e0	58	12	produces	produce	VBZ
cord-297178-moxhk2e0	58	13	more	more	RBR
cord-297178-moxhk2e0	58	14	chemotactic	chemotactic	JJ
cord-297178-moxhk2e0	58	15	factors	factor	NNS
cord-297178-moxhk2e0	58	16	for	for	IN
cord-297178-moxhk2e0	58	17	monocytes	monocyte	NNS
cord-297178-moxhk2e0	58	18	(	(	-LRB-
cord-297178-moxhk2e0	58	19	CCL2	CCL2	NNP
cord-297178-moxhk2e0	58	20	,	,	,
cord-297178-moxhk2e0	58	21	CCL7	CCL7	NNP
cord-297178-moxhk2e0	58	22	and	and	CC
cord-297178-moxhk2e0	58	23	CCL12	CCL12	NNP
cord-297178-moxhk2e0	58	24	)	)	-RRB-
cord-297178-moxhk2e0	58	25	,	,	,
cord-297178-moxhk2e0	58	26	resulting	result	VBG
cord-297178-moxhk2e0	58	27	in	in	IN
cord-297178-moxhk2e0	58	28	the	the	DT
cord-297178-moxhk2e0	58	29	additional	additional	JJ
cord-297178-moxhk2e0	58	30	accumulation	accumulation	NN
cord-297178-moxhk2e0	58	31	of	of	IN
cord-297178-moxhk2e0	58	32	mononuclear	mononuclear	JJ
cord-297178-moxhk2e0	58	33	macrophages	macrophage	NNS
cord-297178-moxhk2e0	58	34	,	,	,
cord-297178-moxhk2e0	58	35	and	and	CC
cord-297178-moxhk2e0	58	36	subsequently	subsequently	RB
cord-297178-moxhk2e0	58	37	,	,	,
cord-297178-moxhk2e0	58	38	an	an	DT
cord-297178-moxhk2e0	58	39	increase	increase	NN
cord-297178-moxhk2e0	58	40	in	in	IN
cord-297178-moxhk2e0	58	41	the	the	DT
cord-297178-moxhk2e0	58	42	levels	level	NNS
cord-297178-moxhk2e0	58	43	of	of	IN
cord-297178-moxhk2e0	58	44	pro	pro	JJ
cord-297178-moxhk2e0	58	45	-	-	JJ
cord-297178-moxhk2e0	58	46	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	58	47	cytokines	cytokine	NNS
cord-297178-moxhk2e0	58	48	(	(	-LRB-
cord-297178-moxhk2e0	58	49	TNF	TNF	NNP
cord-297178-moxhk2e0	58	50	,	,	,
cord-297178-moxhk2e0	58	51	IL-6	IL-6	NNP
cord-297178-moxhk2e0	58	52	,	,	,
cord-297178-moxhk2e0	58	53	IL1-β	IL1-β	NNPS
cord-297178-moxhk2e0	58	54	and	and	CC
cord-297178-moxhk2e0	58	55	inducible	inducible	JJ
cord-297178-moxhk2e0	58	56	nitric	nitric	NN
cord-297178-moxhk2e0	58	57	oxide	oxide	NN
cord-297178-moxhk2e0	58	58	synthase	synthase	NN
cord-297178-moxhk2e0	58	59	)	)	-RRB-
cord-297178-moxhk2e0	58	60	,	,	,
cord-297178-moxhk2e0	58	61	thus	thus	RB
cord-297178-moxhk2e0	58	62	increasing	increase	VBG
cord-297178-moxhk2e0	58	63	the	the	DT
cord-297178-moxhk2e0	58	64	severity	severity	NN
cord-297178-moxhk2e0	58	65	of	of	IN
cord-297178-moxhk2e0	58	66	the	the	DT
cord-297178-moxhk2e0	58	67	disease	disease	NN
cord-297178-moxhk2e0	58	68	[	[	-LRB-
cord-297178-moxhk2e0	58	69	35	35	CD
cord-297178-moxhk2e0	58	70	]	]	-RRB-
cord-297178-moxhk2e0	58	71	.	.	.
cord-297178-moxhk2e0	59	1	In	in	IN
cord-297178-moxhk2e0	59	2	severe	severe	JJ
cord-297178-moxhk2e0	59	3	cases	case	NNS
cord-297178-moxhk2e0	59	4	of	of	IN
cord-297178-moxhk2e0	59	5	COVID-19	covid-19	CD
cord-297178-moxhk2e0	59	6	,	,	,
cord-297178-moxhk2e0	59	7	patients	patient	NNS
cord-297178-moxhk2e0	59	8	demonstrate	demonstrate	VBP
cord-297178-moxhk2e0	59	9	elevated	elevated	JJ
cord-297178-moxhk2e0	59	10	plasma	plasma	NN
cord-297178-moxhk2e0	59	11	levels	level	NNS
cord-297178-moxhk2e0	59	12	of	of	IN
cord-297178-moxhk2e0	59	13	IL-2	IL-2	NNP
cord-297178-moxhk2e0	59	14	,	,	,
cord-297178-moxhk2e0	59	15	IL-7	IL-7	NNP
cord-297178-moxhk2e0	59	16	,	,	,
cord-297178-moxhk2e0	59	17	IL-10	IL-10	NNP
cord-297178-moxhk2e0	59	18	,	,	,
cord-297178-moxhk2e0	59	19	granulocyte	granulocyte	NN
cord-297178-moxhk2e0	59	20	colony	colony	NN
cord-297178-moxhk2e0	59	21	stimulating	stimulate	VBG
cord-297178-moxhk2e0	59	22	factor	factor	NN
cord-297178-moxhk2e0	60	1	(	(	-LRB-
cord-297178-moxhk2e0	60	2	G	G	NNP
cord-297178-moxhk2e0	60	3	-	-	HYPH
cord-297178-moxhk2e0	60	4	CSF	CSF	NNP
cord-297178-moxhk2e0	60	5	)	)	-RRB-
cord-297178-moxhk2e0	60	6	,	,	,
cord-297178-moxhk2e0	60	7	IP-10	IP-10	NNP
cord-297178-moxhk2e0	60	8	,	,	,
cord-297178-moxhk2e0	60	9	MCP1	MCP1	NNP
cord-297178-moxhk2e0	60	10	,	,	,
cord-297178-moxhk2e0	60	11	macrophage	macrophage	NN
cord-297178-moxhk2e0	60	12	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	60	13	protein	protein	NN
cord-297178-moxhk2e0	60	14	1α	1α	CD
cord-297178-moxhk2e0	60	15	(	(	-LRB-
cord-297178-moxhk2e0	60	16	MIP1α	MIP1α	NNP
cord-297178-moxhk2e0	60	17	)	)	-RRB-
cord-297178-moxhk2e0	60	18	and	and	CC
cord-297178-moxhk2e0	60	19	tumor	tumor	NN
cord-297178-moxhk2e0	60	20	necrosis	necrosis	NN
cord-297178-moxhk2e0	60	21	factor	factor	NN
cord-297178-moxhk2e0	60	22	(	(	-LRB-
cord-297178-moxhk2e0	60	23	TNF	TNF	NNP
cord-297178-moxhk2e0	60	24	)	)	-RRB-
cord-297178-moxhk2e0	61	1	[	[	-LRB-
cord-297178-moxhk2e0	61	2	34	34	CD
cord-297178-moxhk2e0	61	3	]	]	-RRB-
cord-297178-moxhk2e0	61	4	.	.	.
cord-297178-moxhk2e0	62	1	Viral	viral	JJ
cord-297178-moxhk2e0	62	2	infection	infection	NN
cord-297178-moxhk2e0	62	3	and	and	CC
cord-297178-moxhk2e0	62	4	replication	replication	NN
cord-297178-moxhk2e0	62	5	in	in	IN
cord-297178-moxhk2e0	62	6	airway	airway	JJ
cord-297178-moxhk2e0	62	7	epithelial	epithelial	JJ
cord-297178-moxhk2e0	62	8	cells	cell	NNS
cord-297178-moxhk2e0	62	9	can	can	MD
cord-297178-moxhk2e0	62	10	cause	cause	VB
cord-297178-moxhk2e0	62	11	high	high	JJ
cord-297178-moxhk2e0	62	12	levels	level	NNS
cord-297178-moxhk2e0	62	13	of	of	IN
cord-297178-moxhk2e0	62	14	pyroptosis	pyroptosis	NN
cord-297178-moxhk2e0	62	15	.	.	.
cord-297178-moxhk2e0	63	1	Pyroptosis	Pyroptosis	NNP
cord-297178-moxhk2e0	63	2	is	be	VBZ
cord-297178-moxhk2e0	63	3	a	a	DT
cord-297178-moxhk2e0	63	4	highly	highly	RB
cord-297178-moxhk2e0	63	5	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	63	6	form	form	NN
cord-297178-moxhk2e0	63	7	of	of	IN
cord-297178-moxhk2e0	63	8	programmed	programmed	JJ
cord-297178-moxhk2e0	63	9	cell	cell	NN
cord-297178-moxhk2e0	63	10	death	death	NN
cord-297178-moxhk2e0	63	11	seen	see	VBN
cord-297178-moxhk2e0	63	12	in	in	IN
cord-297178-moxhk2e0	63	13	cytopathic	cytopathic	JJ
cord-297178-moxhk2e0	63	14	viruses	virus	NNS
cord-297178-moxhk2e0	63	15	such	such	JJ
cord-297178-moxhk2e0	63	16	as	as	IN
cord-297178-moxhk2e0	63	17	SARS	SARS	NNP
cord-297178-moxhk2e0	63	18	-	-	HYPH
cord-297178-moxhk2e0	63	19	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	63	20	.	.	.
cord-297178-moxhk2e0	64	1	IL-1β	IL-1β	NNP
cord-297178-moxhk2e0	64	2	,	,	,
cord-297178-moxhk2e0	64	3	an	an	DT
cord-297178-moxhk2e0	64	4	important	important	JJ
cord-297178-moxhk2e0	64	5	cytokine	cytokine	NN
cord-297178-moxhk2e0	64	6	released	release	VBN
cord-297178-moxhk2e0	64	7	during	during	IN
cord-297178-moxhk2e0	64	8	pyroptosis	pyroptosis	NNP
cord-297178-moxhk2e0	64	9	,	,	,
cord-297178-moxhk2e0	64	10	is	be	VBZ
cord-297178-moxhk2e0	64	11	elevated	elevate	VBN
cord-297178-moxhk2e0	64	12	in	in	IN
cord-297178-moxhk2e0	64	13	infection	infection	NN
cord-297178-moxhk2e0	64	14	by	by	IN
cord-297178-moxhk2e0	64	15	SARS	SARS	NNP
cord-297178-moxhk2e0	64	16	-	-	HYPH
cord-297178-moxhk2e0	64	17	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	64	18	,	,	,
cord-297178-moxhk2e0	64	19	thus	thus	RB
cord-297178-moxhk2e0	64	20	being	be	VBG
cord-297178-moxhk2e0	64	21	a	a	DT
cord-297178-moxhk2e0	64	22	possible	possible	JJ
cord-297178-moxhk2e0	64	23	trigger	trigger	NN
cord-297178-moxhk2e0	64	24	for	for	IN
cord-297178-moxhk2e0	64	25	the	the	DT
cord-297178-moxhk2e0	64	26	cytokine	cytokine	NN
cord-297178-moxhk2e0	64	27	storm	storm	NN
cord-297178-moxhk2e0	64	28	[	[	-LRB-
cord-297178-moxhk2e0	64	29	34	34	CD
cord-297178-moxhk2e0	64	30	]	]	-RRB-
cord-297178-moxhk2e0	64	31	.	.	.
cord-297178-moxhk2e0	65	1	The	the	DT
cord-297178-moxhk2e0	65	2	excessive	excessive	JJ
cord-297178-moxhk2e0	65	3	or	or	CC
cord-297178-moxhk2e0	65	4	uncontrolled	uncontrolled	JJ
cord-297178-moxhk2e0	65	5	release	release	NN
cord-297178-moxhk2e0	65	6	of	of	IN
cord-297178-moxhk2e0	65	7	pro	pro	JJ
cord-297178-moxhk2e0	65	8	-	-	JJ
cord-297178-moxhk2e0	65	9	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	65	10	cytokines	cytokine	NNS
cord-297178-moxhk2e0	65	11	,	,	,
cord-297178-moxhk2e0	65	12	characteristic	characteristic	JJ
cord-297178-moxhk2e0	65	13	of	of	IN
cord-297178-moxhk2e0	65	14	the	the	DT
cord-297178-moxhk2e0	65	15	cytokine	cytokine	NN
cord-297178-moxhk2e0	65	16	storm	storm	NN
cord-297178-moxhk2e0	65	17	,	,	,
cord-297178-moxhk2e0	65	18	is	be	VBZ
cord-297178-moxhk2e0	65	19	also	also	RB
cord-297178-moxhk2e0	65	20	associated	associate	VBN
cord-297178-moxhk2e0	65	21	with	with	IN
cord-297178-moxhk2e0	65	22	non	non	JJ
cord-297178-moxhk2e0	65	23	-	-	JJ
cord-297178-moxhk2e0	65	24	infectious	infectious	JJ
cord-297178-moxhk2e0	65	25	7	7	CD
cord-297178-moxhk2e0	65	26	diseases	disease	NNS
cord-297178-moxhk2e0	65	27	,	,	,
cord-297178-moxhk2e0	65	28	such	such	JJ
cord-297178-moxhk2e0	65	29	as	as	IN
cord-297178-moxhk2e0	65	30	autoimmune	autoimmune	JJ
cord-297178-moxhk2e0	65	31	diseases	disease	NNS
cord-297178-moxhk2e0	65	32	[	[	-LRB-
cord-297178-moxhk2e0	65	33	36	36	CD
cord-297178-moxhk2e0	65	34	]	]	-RRB-
cord-297178-moxhk2e0	65	35	.	.	.
cord-297178-moxhk2e0	66	1	Yiguo	Yiguo	NNP
cord-297178-moxhk2e0	66	2	Qiu	Qiu	NNP
cord-297178-moxhk2e0	66	3	et	et	FW
cord-297178-moxhk2e0	66	4	al	al	NNP
cord-297178-moxhk2e0	66	5	.	.	.
cord-297178-moxhk2e0	66	6	analyzed	analyze	VBD
cord-297178-moxhk2e0	66	7	SARS	SARS	NNP
cord-297178-moxhk2e0	66	8	in	in	IN
cord-297178-moxhk2e0	66	9	mice	mouse	NNS
cord-297178-moxhk2e0	66	10	with	with	IN
cord-297178-moxhk2e0	66	11	autoimmune	autoimmune	JJ
cord-297178-moxhk2e0	66	12	uveitis	uveitis	NN
cord-297178-moxhk2e0	66	13	.	.	.
cord-297178-moxhk2e0	67	1	The	the	DT
cord-297178-moxhk2e0	67	2	study	study	NN
cord-297178-moxhk2e0	67	3	demonstrated	demonstrate	VBD
cord-297178-moxhk2e0	67	4	that	that	IN
cord-297178-moxhk2e0	67	5	the	the	DT
cord-297178-moxhk2e0	67	6	administration	administration	NN
cord-297178-moxhk2e0	67	7	of	of	IN
cord-297178-moxhk2e0	67	8	Ang	Ang	NNP
cord-297178-moxhk2e0	67	9	1	1	CD
cord-297178-moxhk2e0	67	10	-	-	SYM
cord-297178-moxhk2e0	67	11	7	7	CD
cord-297178-moxhk2e0	67	12	antagonist	antagonist	NN
cord-297178-moxhk2e0	67	13	reversed	reverse	VBD
cord-297178-moxhk2e0	67	14	the	the	DT
cord-297178-moxhk2e0	67	15	protective	protective	JJ
cord-297178-moxhk2e0	67	16	effects	effect	NNS
cord-297178-moxhk2e0	67	17	of	of	IN
cord-297178-moxhk2e0	67	18	ACE2	ACE2	NNP
cord-297178-moxhk2e0	67	19	on	on	IN
cord-297178-moxhk2e0	67	20	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	67	21	signals	signal	NNS
cord-297178-moxhk2e0	67	22	and	and	CC
cord-297178-moxhk2e0	67	23	on	on	IN
cord-297178-moxhk2e0	67	24	the	the	DT
cord-297178-moxhk2e0	67	25	production	production	NN
cord-297178-moxhk2e0	67	26	of	of	IN
cord-297178-moxhk2e0	67	27	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	67	28	cytokines	cytokine	NNS
cord-297178-moxhk2e0	67	29	,	,	,
cord-297178-moxhk2e0	67	30	as	as	RB
cord-297178-moxhk2e0	67	31	well	well	RB
cord-297178-moxhk2e0	67	32	as	as	IN
cord-297178-moxhk2e0	67	33	on	on	IN
cord-297178-moxhk2e0	67	34	the	the	DT
cord-297178-moxhk2e0	67	35	regulation	regulation	NN
cord-297178-moxhk2e0	67	36	of	of	IN
cord-297178-moxhk2e0	67	37	local	local	JJ
cord-297178-moxhk2e0	67	38	immune	immune	JJ
cord-297178-moxhk2e0	67	39	responses	response	NNS
cord-297178-moxhk2e0	67	40	.	.	.
cord-297178-moxhk2e0	68	1	The	the	DT
cord-297178-moxhk2e0	68	2	inhibition	inhibition	NN
cord-297178-moxhk2e0	68	3	of	of	IN
cord-297178-moxhk2e0	68	4	Ang	Ang	NNP
cord-297178-moxhk2e0	68	5	1	1	CD
cord-297178-moxhk2e0	68	6	-	-	SYM
cord-297178-moxhk2e0	68	7	7	7	CD
cord-297178-moxhk2e0	68	8	increased	increase	VBD
cord-297178-moxhk2e0	68	9	the	the	DT
cord-297178-moxhk2e0	68	10	production	production	NN
cord-297178-moxhk2e0	68	11	of	of	IN
cord-297178-moxhk2e0	68	12	the	the	DT
cord-297178-moxhk2e0	68	13	pro	pro	JJ
cord-297178-moxhk2e0	68	14	-	-	JJ
cord-297178-moxhk2e0	68	15	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	68	16	cytokines	cytokine	NNS
cord-297178-moxhk2e0	68	17	IL-6	IL-6	NNP
cord-297178-moxhk2e0	68	18	,	,	,
cord-297178-moxhk2e0	68	19	IL-1β	IL-1β	NNP
cord-297178-moxhk2e0	68	20	,	,	,
cord-297178-moxhk2e0	68	21	TNF	TNF	NNP
cord-297178-moxhk2e0	68	22	-	-	HYPH
cord-297178-moxhk2e0	68	23	α	α	NNP
cord-297178-moxhk2e0	68	24	,	,	,
cord-297178-moxhk2e0	68	25	and	and	CC
cord-297178-moxhk2e0	68	26	MCP-1	MCP-1	NNP
cord-297178-moxhk2e0	68	27	[	[	-LRB-
cord-297178-moxhk2e0	68	28	37	37	CD
cord-297178-moxhk2e0	68	29	]	]	-RRB-
cord-297178-moxhk2e0	68	30	.	.	.
cord-297178-moxhk2e0	69	1	This	this	DT
cord-297178-moxhk2e0	69	2	study	study	NN
cord-297178-moxhk2e0	69	3	demonstrates	demonstrate	VBZ
cord-297178-moxhk2e0	69	4	the	the	DT
cord-297178-moxhk2e0	69	5	importance	importance	NN
cord-297178-moxhk2e0	69	6	of	of	IN
cord-297178-moxhk2e0	69	7	Ang	Ang	NNP
cord-297178-moxhk2e0	69	8	1	1	CD
cord-297178-moxhk2e0	69	9	-	-	SYM
cord-297178-moxhk2e0	69	10	7	7	CD
cord-297178-moxhk2e0	69	11	in	in	IN
cord-297178-moxhk2e0	69	12	mediating	mediate	VBG
cord-297178-moxhk2e0	69	13	the	the	DT
cord-297178-moxhk2e0	69	14	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	69	15	process	process	NN
cord-297178-moxhk2e0	69	16	,	,	,
cord-297178-moxhk2e0	69	17	as	as	IN
cord-297178-moxhk2e0	69	18	its	-PRON-	PRP$
cord-297178-moxhk2e0	69	19	inhibition	inhibition	NN
cord-297178-moxhk2e0	69	20	can	can	MD
cord-297178-moxhk2e0	69	21	cause	cause	VB
cord-297178-moxhk2e0	69	22	an	an	DT
cord-297178-moxhk2e0	69	23	increase	increase	NN
cord-297178-moxhk2e0	69	24	in	in	IN
cord-297178-moxhk2e0	69	25	the	the	DT
cord-297178-moxhk2e0	69	26	production	production	NN
cord-297178-moxhk2e0	69	27	of	of	IN
cord-297178-moxhk2e0	69	28	pro	pro	JJ
cord-297178-moxhk2e0	69	29	-	-	JJ
cord-297178-moxhk2e0	69	30	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	69	31	cytokines	cytokine	NNS
cord-297178-moxhk2e0	69	32	,	,	,
cord-297178-moxhk2e0	69	33	similar	similar	JJ
cord-297178-moxhk2e0	69	34	to	to	IN
cord-297178-moxhk2e0	69	35	that	that	DT
cord-297178-moxhk2e0	69	36	observed	observe	VBN
cord-297178-moxhk2e0	69	37	in	in	IN
cord-297178-moxhk2e0	69	38	the	the	DT
cord-297178-moxhk2e0	69	39	cytokine	cytokine	NN
cord-297178-moxhk2e0	69	40	storm	storm	NN
cord-297178-moxhk2e0	69	41	in	in	IN
cord-297178-moxhk2e0	69	42	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	69	43	.	.	.
cord-297178-moxhk2e0	70	1	ACE2	ACE2	NNP
cord-297178-moxhk2e0	70	2	plays	play	VBZ
cord-297178-moxhk2e0	70	3	a	a	DT
cord-297178-moxhk2e0	70	4	crucial	crucial	JJ
cord-297178-moxhk2e0	70	5	role	role	NN
cord-297178-moxhk2e0	70	6	in	in	IN
cord-297178-moxhk2e0	70	7	RAS	RAS	NNP
cord-297178-moxhk2e0	70	8	because	because	IN
cord-297178-moxhk2e0	70	9	it	-PRON-	PRP
cord-297178-moxhk2e0	70	10	neutralizes	neutralize	VBZ
cord-297178-moxhk2e0	70	11	ACE	ace	NN
cord-297178-moxhk2e0	70	12	activity	activity	NN
cord-297178-moxhk2e0	70	13	by	by	IN
cord-297178-moxhk2e0	70	14	degrading	degrade	VBG
cord-297178-moxhk2e0	70	15	Ang	Ang	NNP
cord-297178-moxhk2e0	70	16	I	-PRON-	PRP
cord-297178-moxhk2e0	70	17	in	in	IN
cord-297178-moxhk2e0	70	18	Ang	Ang	NNP
cord-297178-moxhk2e0	70	19	(	(	-LRB-
cord-297178-moxhk2e0	70	20	1	1	CD
cord-297178-moxhk2e0	70	21	-	-	SYM
cord-297178-moxhk2e0	70	22	9	9	CD
cord-297178-moxhk2e0	70	23	)	)	-RRB-
cord-297178-moxhk2e0	70	24	,	,	,
cord-297178-moxhk2e0	70	25	as	as	RB
cord-297178-moxhk2e0	70	26	well	well	RB
cord-297178-moxhk2e0	70	27	as	as	IN
cord-297178-moxhk2e0	70	28	hydrolyzing	hydrolyzing	NNP
cord-297178-moxhk2e0	70	29	Ang	Ang	NNP
cord-297178-moxhk2e0	70	30	II	II	NNP
cord-297178-moxhk2e0	70	31	,	,	,
cord-297178-moxhk2e0	70	32	producing	produce	VBG
cord-297178-moxhk2e0	70	33	Ang	Ang	NNP
cord-297178-moxhk2e0	70	34	(	(	-LRB-
cord-297178-moxhk2e0	70	35	1	1	CD
cord-297178-moxhk2e0	70	36	-	-	SYM
cord-297178-moxhk2e0	70	37	7	7	CD
cord-297178-moxhk2e0	70	38	)	)	-RRB-
cord-297178-moxhk2e0	71	1	[	[	-LRB-
cord-297178-moxhk2e0	71	2	38	38	CD
cord-297178-moxhk2e0	71	3	]	]	-RRB-
cord-297178-moxhk2e0	71	4	.	.	.
cord-297178-moxhk2e0	72	1	Thus	thus	RB
cord-297178-moxhk2e0	72	2	,	,	,
cord-297178-moxhk2e0	72	3	ACE2	ACE2	NNP
cord-297178-moxhk2e0	72	4	is	be	VBZ
cord-297178-moxhk2e0	72	5	essential	essential	JJ
cord-297178-moxhk2e0	72	6	to	to	TO
cord-297178-moxhk2e0	72	7	stimulate	stimulate	VB
cord-297178-moxhk2e0	72	8	the	the	DT
cord-297178-moxhk2e0	72	9	beneficial	beneficial	JJ
cord-297178-moxhk2e0	72	10	effects	effect	NNS
cord-297178-moxhk2e0	72	11	of	of	IN
cord-297178-moxhk2e0	72	12	the	the	DT
cord-297178-moxhk2e0	72	13	protective	protective	JJ
cord-297178-moxhk2e0	72	14	axis	axis	NN
cord-297178-moxhk2e0	72	15	of	of	IN
cord-297178-moxhk2e0	72	16	RAS	RAS	NNP
cord-297178-moxhk2e0	72	17	,	,	,
cord-297178-moxhk2e0	72	18	ACE2	ACE2	NNP
cord-297178-moxhk2e0	72	19	/	/	,
cord-297178-moxhk2e0	73	1	Ang	Ang	NNP
cord-297178-moxhk2e0	74	1	(	(	-LRB-
cord-297178-moxhk2e0	74	2	1	1	CD
cord-297178-moxhk2e0	74	3	-	-	SYM
cord-297178-moxhk2e0	74	4	7	7	CD
cord-297178-moxhk2e0	74	5	)	)	-RRB-
cord-297178-moxhk2e0	74	6	/	/	SYM
cord-297178-moxhk2e0	74	7	Mas	Mas	NNP
cord-297178-moxhk2e0	74	8	,	,	,
cord-297178-moxhk2e0	74	9	and	and	CC
cord-297178-moxhk2e0	74	10	to	to	TO
cord-297178-moxhk2e0	74	11	mitigate	mitigate	VB
cord-297178-moxhk2e0	74	12	the	the	DT
cord-297178-moxhk2e0	74	13	deleterious	deleterious	JJ
cord-297178-moxhk2e0	74	14	effects	effect	NNS
cord-297178-moxhk2e0	74	15	of	of	IN
cord-297178-moxhk2e0	74	16	the	the	DT
cord-297178-moxhk2e0	74	17	harmful	harmful	JJ
cord-297178-moxhk2e0	74	18	axis	axis	NN
cord-297178-moxhk2e0	74	19	of	of	IN
cord-297178-moxhk2e0	74	20	RAS	RAS	NNP
cord-297178-moxhk2e0	74	21	,	,	,
cord-297178-moxhk2e0	74	22	ACE	ACE	NNP
cord-297178-moxhk2e0	74	23	/	/	SYM
cord-297178-moxhk2e0	74	24	Ang	Ang	NNP
cord-297178-moxhk2e0	74	25	II	II	NNP
cord-297178-moxhk2e0	74	26	/	/	SYM
cord-297178-moxhk2e0	74	27	AT1	at1	NN
cord-297178-moxhk2e0	74	28	.	.	.
cord-297178-moxhk2e0	75	1	Maintaining	maintain	VBG
cord-297178-moxhk2e0	75	2	normal	normal	JJ
cord-297178-moxhk2e0	75	3	levels	level	NNS
cord-297178-moxhk2e0	75	4	of	of	IN
cord-297178-moxhk2e0	75	5	ACE2	ACE2	NNP
cord-297178-moxhk2e0	75	6	in	in	IN
cord-297178-moxhk2e0	75	7	the	the	DT
cord-297178-moxhk2e0	75	8	lung	lung	NN
cord-297178-moxhk2e0	75	9	is	be	VBZ
cord-297178-moxhk2e0	75	10	beneficial	beneficial	JJ
cord-297178-moxhk2e0	75	11	for	for	IN
cord-297178-moxhk2e0	75	12	combating	combat	VBG
cord-297178-moxhk2e0	75	13	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	75	14	lung	lung	NN
cord-297178-moxhk2e0	75	15	disease	disease	NN
cord-297178-moxhk2e0	75	16	.	.	.
cord-297178-moxhk2e0	76	1	The	the	DT
cord-297178-moxhk2e0	76	2	reduction	reduction	NN
cord-297178-moxhk2e0	76	3	in	in	IN
cord-297178-moxhk2e0	76	4	ACE2	ACE2	NNP
cord-297178-moxhk2e0	76	5	expression	expression	NN
cord-297178-moxhk2e0	76	6	may	may	MD
cord-297178-moxhk2e0	76	7	be	be	VB
cord-297178-moxhk2e0	76	8	related	relate	VBN
cord-297178-moxhk2e0	76	9	to	to	IN
cord-297178-moxhk2e0	76	10	pulmonary	pulmonary	JJ
cord-297178-moxhk2e0	76	11	inflammation	inflammation	NN
cord-297178-moxhk2e0	76	12	and	and	CC
cord-297178-moxhk2e0	76	13	subsequent	subsequent	JJ
cord-297178-moxhk2e0	76	14	cytokine	cytokine	NN
cord-297178-moxhk2e0	76	15	storm	storm	NN
cord-297178-moxhk2e0	76	16	seen	see	VBN
cord-297178-moxhk2e0	76	17	in	in	IN
cord-297178-moxhk2e0	76	18	patients	patient	NNS
cord-297178-moxhk2e0	76	19	with	with	IN
cord-297178-moxhk2e0	76	20	severe	severe	JJ
cord-297178-moxhk2e0	76	21	COVID-19	covid-19	NN
cord-297178-moxhk2e0	76	22	.	.	.
cord-297178-moxhk2e0	77	1	ACE2	ACE2	NNP
cord-297178-moxhk2e0	77	2	maintains	maintain	VBZ
cord-297178-moxhk2e0	77	3	the	the	DT
cord-297178-moxhk2e0	77	4	proper	proper	JJ
cord-297178-moxhk2e0	77	5	function	function	NN
cord-297178-moxhk2e0	77	6	of	of	IN
cord-297178-moxhk2e0	77	7	the	the	DT
cord-297178-moxhk2e0	77	8	heart	heart	NN
cord-297178-moxhk2e0	77	9	and	and	CC
cord-297178-moxhk2e0	77	10	kidneys	kidney	NNS
cord-297178-moxhk2e0	77	11	,	,	,
cord-297178-moxhk2e0	77	12	and	and	CC
cord-297178-moxhk2e0	77	13	the	the	DT
cord-297178-moxhk2e0	77	14	negative	negative	JJ
cord-297178-moxhk2e0	77	15	regulation	regulation	NN
cord-297178-moxhk2e0	77	16	of	of	IN
cord-297178-moxhk2e0	77	17	ACE2	ACE2	NNP
cord-297178-moxhk2e0	77	18	by	by	IN
cord-297178-moxhk2e0	77	19	SARS	SARS	NNP
cord-297178-moxhk2e0	77	20	-	-	HYPH
cord-297178-moxhk2e0	77	21	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	77	22	can	can	MD
cord-297178-moxhk2e0	77	23	compromise	compromise	VB
cord-297178-moxhk2e0	77	24	this	this	DT
cord-297178-moxhk2e0	77	25	protective	protective	JJ
cord-297178-moxhk2e0	77	26	characteristic	characteristic	NN
cord-297178-moxhk2e0	77	27	and	and	CC
cord-297178-moxhk2e0	77	28	contribute	contribute	VB
cord-297178-moxhk2e0	77	29	to	to	IN
cord-297178-moxhk2e0	77	30	the	the	DT
cord-297178-moxhk2e0	77	31	damage	damage	NN
cord-297178-moxhk2e0	77	32	caused	cause	VBN
cord-297178-moxhk2e0	77	33	by	by	IN
cord-297178-moxhk2e0	77	34	the	the	DT
cord-297178-moxhk2e0	77	35	infection	infection	NN
cord-297178-moxhk2e0	77	36	of	of	IN
cord-297178-moxhk2e0	77	37	these	these	DT
cord-297178-moxhk2e0	77	38	organs	organ	NNS
cord-297178-moxhk2e0	77	39	[	[	-LRB-
cord-297178-moxhk2e0	77	40	38	38	CD
cord-297178-moxhk2e0	77	41	]	]	-RRB-
cord-297178-moxhk2e0	77	42	.	.	.
cord-297178-moxhk2e0	78	1	Renin	renin	NN
cord-297178-moxhk2e0	78	2	-	-	HYPH
cord-297178-moxhk2e0	78	3	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	78	4	system	system	NN
cord-297178-moxhk2e0	78	5	and	and	CC
cord-297178-moxhk2e0	78	6	the	the	DT
cord-297178-moxhk2e0	78	7	self	self	NN
cord-297178-moxhk2e0	78	8	-	-	HYPH
cord-297178-moxhk2e0	78	9	limitative	limitative	JJ
cord-297178-moxhk2e0	78	10	replication	replication	NN
cord-297178-moxhk2e0	78	11	of	of	IN
cord-297178-moxhk2e0	78	12	SARS	SARS	NNP
cord-297178-moxhk2e0	78	13	-	-	HYPH
cord-297178-moxhk2e0	78	14	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	78	15	RAS	RAS	NNP
cord-297178-moxhk2e0	78	16	is	be	VBZ
cord-297178-moxhk2e0	78	17	classified	classify	VBN
cord-297178-moxhk2e0	78	18	as	as	IN
cord-297178-moxhk2e0	78	19	systemic	systemic	JJ
cord-297178-moxhk2e0	78	20	(	(	-LRB-
cord-297178-moxhk2e0	78	21	classic	classic	JJ
cord-297178-moxhk2e0	78	22	)	)	-RRB-
cord-297178-moxhk2e0	78	23	and	and	CC
cord-297178-moxhk2e0	78	24	local	local	JJ
cord-297178-moxhk2e0	78	25	,	,	,
cord-297178-moxhk2e0	78	26	and	and	CC
cord-297178-moxhk2e0	78	27	the	the	DT
cord-297178-moxhk2e0	78	28	interaction	interaction	NN
cord-297178-moxhk2e0	78	29	between	between	IN
cord-297178-moxhk2e0	78	30	them	-PRON-	PRP
cord-297178-moxhk2e0	78	31	is	be	VBZ
cord-297178-moxhk2e0	78	32	fundamental	fundamental	JJ
cord-297178-moxhk2e0	78	33	to	to	IN
cord-297178-moxhk2e0	78	34	homeostasis	homeostasis	NN
cord-297178-moxhk2e0	78	35	[	[	-LRB-
cord-297178-moxhk2e0	78	36	9,10,39	9,10,39	CD
cord-297178-moxhk2e0	78	37	]	]	-RRB-
cord-297178-moxhk2e0	78	38	.	.	.
cord-297178-moxhk2e0	79	1	This	this	DT
cord-297178-moxhk2e0	79	2	interaction	interaction	NN
cord-297178-moxhk2e0	79	3	between	between	IN
cord-297178-moxhk2e0	79	4	local	local	JJ
cord-297178-moxhk2e0	79	5	8	8	CD
cord-297178-moxhk2e0	79	6	and	and	CC
cord-297178-moxhk2e0	79	7	systemic	systemic	JJ
cord-297178-moxhk2e0	79	8	RAS	RAS	NNP
cord-297178-moxhk2e0	79	9	probably	probably	RB
cord-297178-moxhk2e0	79	10	occurs	occur	VBZ
cord-297178-moxhk2e0	79	11	through	through	IN
cord-297178-moxhk2e0	79	12	the	the	DT
cord-297178-moxhk2e0	79	13	circulation	circulation	NN
cord-297178-moxhk2e0	79	14	of	of	IN
cord-297178-moxhk2e0	79	15	soluble	soluble	JJ
cord-297178-moxhk2e0	79	16	ACE	ACE	NNP
cord-297178-moxhk2e0	79	17	and	and	CC
cord-297178-moxhk2e0	79	18	ACE2	ACE2	NNP
cord-297178-moxhk2e0	79	19	.	.	.
cord-297178-moxhk2e0	80	1	Although	although	IN
cord-297178-moxhk2e0	80	2	they	-PRON-	PRP
cord-297178-moxhk2e0	80	3	are	be	VBP
cord-297178-moxhk2e0	80	4	transmembrane	transmembrane	NN
cord-297178-moxhk2e0	80	5	proteins	protein	NNS
cord-297178-moxhk2e0	80	6	,	,	,
cord-297178-moxhk2e0	80	7	ACE	ACE	NNP
cord-297178-moxhk2e0	80	8	and	and	CC
cord-297178-moxhk2e0	80	9	ACE2	ACE2	NNP
cord-297178-moxhk2e0	80	10	may	may	MD
cord-297178-moxhk2e0	80	11	undergo	undergo	VB
cord-297178-moxhk2e0	80	12	a	a	DT
cord-297178-moxhk2e0	80	13	cleavage	cleavage	NN
cord-297178-moxhk2e0	80	14	process	process	NN
cord-297178-moxhk2e0	80	15	by	by	IN
cord-297178-moxhk2e0	80	16	ACE	ACE	NNP
cord-297178-moxhk2e0	80	17	secretase	secretase	NN
cord-297178-moxhk2e0	80	18	and	and	CC
cord-297178-moxhk2e0	80	19	ADAM17	ADAM17	NNP
cord-297178-moxhk2e0	80	20	,	,	,
cord-297178-moxhk2e0	80	21	respectively	respectively	RB
cord-297178-moxhk2e0	80	22	,	,	,
cord-297178-moxhk2e0	80	23	releasing	release	VBG
cord-297178-moxhk2e0	80	24	an	an	DT
cord-297178-moxhk2e0	80	25	active	active	JJ
cord-297178-moxhk2e0	80	26	extracellular	extracellular	JJ
cord-297178-moxhk2e0	80	27	domain	domain	NN
cord-297178-moxhk2e0	80	28	.	.	.
cord-297178-moxhk2e0	81	1	This	this	DT
cord-297178-moxhk2e0	81	2	soluble	soluble	JJ
cord-297178-moxhk2e0	81	3	component	component	NN
cord-297178-moxhk2e0	81	4	is	be	VBZ
cord-297178-moxhk2e0	81	5	capable	capable	JJ
cord-297178-moxhk2e0	81	6	of	of	IN
cord-297178-moxhk2e0	81	7	converting	convert	VBG
cord-297178-moxhk2e0	81	8	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	81	9	I	-PRON-	PRP
cord-297178-moxhk2e0	81	10	into	into	IN
cord-297178-moxhk2e0	81	11	Ang	Ang	NNP
cord-297178-moxhk2e0	81	12	II	II	NNP
cord-297178-moxhk2e0	81	13	(	(	-LRB-
cord-297178-moxhk2e0	81	14	ACE	ACE	NNP
cord-297178-moxhk2e0	81	15	)	)	-RRB-
cord-297178-moxhk2e0	81	16	and	and	CC
cord-297178-moxhk2e0	81	17	Ang	Ang	NNP
cord-297178-moxhk2e0	81	18	II	II	NNP
cord-297178-moxhk2e0	81	19	into	into	IN
cord-297178-moxhk2e0	81	20	Ang	Ang	NNP
cord-297178-moxhk2e0	81	21	1	1	CD
cord-297178-moxhk2e0	81	22	-	-	SYM
cord-297178-moxhk2e0	81	23	7	7	CD
cord-297178-moxhk2e0	81	24	(	(	-LRB-
cord-297178-moxhk2e0	81	25	ACE2	ACE2	NNP
cord-297178-moxhk2e0	81	26	)	)	-RRB-
cord-297178-moxhk2e0	81	27	[	[	-LRB-
cord-297178-moxhk2e0	81	28	39	39	CD
cord-297178-moxhk2e0	81	29	,	,	,
cord-297178-moxhk2e0	81	30	40	40	CD
cord-297178-moxhk2e0	81	31	]	]	-RRB-
cord-297178-moxhk2e0	81	32	.	.	.
cord-297178-moxhk2e0	82	1	The	the	DT
cord-297178-moxhk2e0	82	2	balance	balance	NN
cord-297178-moxhk2e0	82	3	between	between	IN
cord-297178-moxhk2e0	82	4	the	the	DT
cord-297178-moxhk2e0	82	5	amount	amount	NN
cord-297178-moxhk2e0	82	6	of	of	IN
cord-297178-moxhk2e0	82	7	transmembrane	transmembrane	NN
cord-297178-moxhk2e0	82	8	ACE	ace	NN
cord-297178-moxhk2e0	82	9	and	and	CC
cord-297178-moxhk2e0	82	10	soluble	soluble	JJ
cord-297178-moxhk2e0	82	11	ACE	ace	NN
cord-297178-moxhk2e0	82	12	is	be	VBZ
cord-297178-moxhk2e0	82	13	imperative	imperative	JJ
cord-297178-moxhk2e0	82	14	,	,	,
cord-297178-moxhk2e0	82	15	because	because	IN
cord-297178-moxhk2e0	82	16	the	the	DT
cord-297178-moxhk2e0	82	17	excessive	excessive	JJ
cord-297178-moxhk2e0	82	18	release	release	NN
cord-297178-moxhk2e0	82	19	of	of	IN
cord-297178-moxhk2e0	82	20	the	the	DT
cord-297178-moxhk2e0	82	21	soluble	soluble	JJ
cord-297178-moxhk2e0	82	22	form	form	NN
cord-297178-moxhk2e0	82	23	to	to	IN
cord-297178-moxhk2e0	82	24	the	the	DT
cord-297178-moxhk2e0	82	25	extracellular	extracellular	JJ
cord-297178-moxhk2e0	82	26	environment	environment	NN
cord-297178-moxhk2e0	82	27	could	could	MD
cord-297178-moxhk2e0	82	28	lead	lead	VB
cord-297178-moxhk2e0	82	29	to	to	IN
cord-297178-moxhk2e0	82	30	local	local	JJ
cord-297178-moxhk2e0	82	31	tissue	tissue	NN
cord-297178-moxhk2e0	82	32	injury	injury	NN
cord-297178-moxhk2e0	82	33	,	,	,
cord-297178-moxhk2e0	82	34	since	since	IN
cord-297178-moxhk2e0	82	35	it	-PRON-	PRP
cord-297178-moxhk2e0	82	36	will	will	MD
cord-297178-moxhk2e0	82	37	cause	cause	VB
cord-297178-moxhk2e0	82	38	misbalance	misbalance	NN
cord-297178-moxhk2e0	82	39	on	on	IN
cord-297178-moxhk2e0	82	40	the	the	DT
cord-297178-moxhk2e0	82	41	production	production	NN
cord-297178-moxhk2e0	82	42	of	of	IN
cord-297178-moxhk2e0	82	43	local	local	JJ
cord-297178-moxhk2e0	82	44	Ang	Ang	NNP
cord-297178-moxhk2e0	82	45	II	II	NNP
cord-297178-moxhk2e0	82	46	and	and	CC
cord-297178-moxhk2e0	82	47	Ang	Ang	NNP
cord-297178-moxhk2e0	82	48	1	1	CD
cord-297178-moxhk2e0	82	49	-	-	SYM
cord-297178-moxhk2e0	82	50	7	7	CD
cord-297178-moxhk2e0	82	51	.	.	.
cord-297178-moxhk2e0	83	1	The	the	DT
cord-297178-moxhk2e0	83	2	local	local	JJ
cord-297178-moxhk2e0	83	3	RAS	RAS	NNP
cord-297178-moxhk2e0	83	4	misbalance	misbalance	NN
cord-297178-moxhk2e0	83	5	makes	make	VBZ
cord-297178-moxhk2e0	83	6	the	the	DT
cord-297178-moxhk2e0	83	7	harmful	harmful	JJ
cord-297178-moxhk2e0	83	8	pathway	pathway	NN
cord-297178-moxhk2e0	83	9	effects	effect	NNS
cord-297178-moxhk2e0	83	10	prevail	prevail	VBP
cord-297178-moxhk2e0	83	11	(	(	-LRB-
cord-297178-moxhk2e0	84	1	ACE	ACE	NNP
cord-297178-moxhk2e0	84	2	-Ang	-ang	JJ
cord-297178-moxhk2e0	84	3	II	II	NNP
cord-297178-moxhk2e0	84	4	-AT1R	-AT1R	NNP
cord-297178-moxhk2e0	84	5	)	)	-RRB-
cord-297178-moxhk2e0	84	6	on	on	IN
cord-297178-moxhk2e0	84	7	the	the	DT
cord-297178-moxhk2e0	84	8	referred	refer	VBN
cord-297178-moxhk2e0	84	9	organ	organ	NN
cord-297178-moxhk2e0	84	10	or	or	CC
cord-297178-moxhk2e0	84	11	tissue	tissue	NN
cord-297178-moxhk2e0	84	12	[	[	-LRB-
cord-297178-moxhk2e0	84	13	41	41	CD
cord-297178-moxhk2e0	84	14	]	]	-RRB-
cord-297178-moxhk2e0	84	15	.	.	.
cord-297178-moxhk2e0	85	1	In	in	IN
cord-297178-moxhk2e0	85	2	an	an	DT
cord-297178-moxhk2e0	85	3	ACE2	ACE2	NNP
cord-297178-moxhk2e0	85	4	receptor	receptor	NN
cord-297178-moxhk2e0	85	5	-	-	HYPH
cord-297178-moxhk2e0	85	6	dependent	dependent	JJ
cord-297178-moxhk2e0	85	7	viral	viral	JJ
cord-297178-moxhk2e0	85	8	infection	infection	NN
cord-297178-moxhk2e0	85	9	(	(	-LRB-
cord-297178-moxhk2e0	85	10	Coronavirus	Coronavirus	NNP
cord-297178-moxhk2e0	85	11	NL63	NL63	NNP
cord-297178-moxhk2e0	85	12	)	)	-RRB-
cord-297178-moxhk2e0	85	13	,	,	,
cord-297178-moxhk2e0	85	14	the	the	DT
cord-297178-moxhk2e0	85	15	reduction	reduction	NN
cord-297178-moxhk2e0	85	16	of	of	IN
cord-297178-moxhk2e0	85	17	ACE2	ACE2	NNP
cord-297178-moxhk2e0	85	18	cellular	cellular	JJ
cord-297178-moxhk2e0	85	19	level	level	NN
cord-297178-moxhk2e0	85	20	occurs	occur	VBZ
cord-297178-moxhk2e0	85	21	without	without	IN
cord-297178-moxhk2e0	85	22	changes	change	NNS
cord-297178-moxhk2e0	85	23	in	in	IN
cord-297178-moxhk2e0	85	24	ACE	ace	NN
cord-297178-moxhk2e0	85	25	levels	level	NNS
cord-297178-moxhk2e0	85	26	[	[	-LRB-
cord-297178-moxhk2e0	85	27	42	42	CD
cord-297178-moxhk2e0	85	28	]	]	-RRB-
cord-297178-moxhk2e0	85	29	.	.	.
cord-297178-moxhk2e0	86	1	This	this	DT
cord-297178-moxhk2e0	86	2	finding	finding	NN
cord-297178-moxhk2e0	86	3	,	,	,
cord-297178-moxhk2e0	86	4	plus	plus	CC
cord-297178-moxhk2e0	86	5	the	the	DT
cord-297178-moxhk2e0	86	6	fact	fact	NN
cord-297178-moxhk2e0	86	7	that	that	IN
cord-297178-moxhk2e0	86	8	SARS	SARS	NNP
cord-297178-moxhk2e0	86	9	-	-	HYPH
cord-297178-moxhk2e0	86	10	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	86	11	elicits	elicit	VBZ
cord-297178-moxhk2e0	86	12	a	a	DT
cord-297178-moxhk2e0	86	13	low	low	JJ
cord-297178-moxhk2e0	86	14	immune	immune	NN
cord-297178-moxhk2e0	86	15	and	and	CC
cord-297178-moxhk2e0	86	16	inflammatory	inflammatory	JJ
cord-297178-moxhk2e0	86	17	response	response	NN
cord-297178-moxhk2e0	86	18	,	,	,
cord-297178-moxhk2e0	86	19	even	even	RB
cord-297178-moxhk2e0	86	20	when	when	WRB
cord-297178-moxhk2e0	86	21	compared	compare	VBN
cord-297178-moxhk2e0	86	22	to	to	IN
cord-297178-moxhk2e0	86	23	SARS	SARS	NNP
cord-297178-moxhk2e0	86	24	-	-	HYPH
cord-297178-moxhk2e0	86	25	CoV	CoV	NNP
cord-297178-moxhk2e0	86	26	[	[	-LRB-
cord-297178-moxhk2e0	86	27	25	25	CD
cord-297178-moxhk2e0	86	28	]	]	-RRB-
cord-297178-moxhk2e0	86	29	,	,	,
cord-297178-moxhk2e0	86	30	is	be	VBZ
cord-297178-moxhk2e0	86	31	more	more	JJR
cord-297178-moxhk2e0	86	32	evidence	evidence	NN
cord-297178-moxhk2e0	86	33	that	that	IN
cord-297178-moxhk2e0	86	34	COVID-19	covid-19	JJ
cord-297178-moxhk2e0	86	35	pathogenesis	pathogenesis	NN
cord-297178-moxhk2e0	86	36	is	be	VBZ
cord-297178-moxhk2e0	86	37	more	more	RBR
cord-297178-moxhk2e0	86	38	related	related	JJ
cord-297178-moxhk2e0	86	39	to	to	IN
cord-297178-moxhk2e0	86	40	RAS	RAS	NNP
cord-297178-moxhk2e0	86	41	misbalance	misbalance	NN
cord-297178-moxhk2e0	86	42	than	than	IN
cord-297178-moxhk2e0	86	43	to	to	IN
cord-297178-moxhk2e0	86	44	the	the	DT
cord-297178-moxhk2e0	86	45	viral	viral	JJ
cord-297178-moxhk2e0	86	46	action	action	NN
cord-297178-moxhk2e0	86	47	itself	-PRON-	PRP
cord-297178-moxhk2e0	86	48	.	.	.
cord-297178-moxhk2e0	87	1	Mossel	Mossel	NNP
cord-297178-moxhk2e0	88	1	Although	although	IN
cord-297178-moxhk2e0	88	2	the	the	DT
cord-297178-moxhk2e0	88	3	protease	protease	NN
cord-297178-moxhk2e0	88	4	activity	activity	NN
cord-297178-moxhk2e0	88	5	of	of	IN
cord-297178-moxhk2e0	88	6	ADAM17	adam17	NN
cord-297178-moxhk2e0	88	7	over	over	IN
cord-297178-moxhk2e0	88	8	ACE2	ACE2	NNP
cord-297178-moxhk2e0	88	9	is	be	VBZ
cord-297178-moxhk2e0	88	10	observed	observe	VBN
cord-297178-moxhk2e0	88	11	,	,	,
cord-297178-moxhk2e0	88	12	the	the	DT
cord-297178-moxhk2e0	88	13	same	same	JJ
cord-297178-moxhk2e0	88	14	is	be	VBZ
cord-297178-moxhk2e0	88	15	11	11	CD
cord-297178-moxhk2e0	88	16	not	not	RB
cord-297178-moxhk2e0	88	17	observed	observe	VBN
cord-297178-moxhk2e0	88	18	in	in	IN
cord-297178-moxhk2e0	88	19	ACE	ace	NN
cord-297178-moxhk2e0	88	20	[	[	-LRB-
cord-297178-moxhk2e0	88	21	55	55	CD
cord-297178-moxhk2e0	88	22	]	]	-RRB-
cord-297178-moxhk2e0	89	1	[	[	-LRB-
cord-297178-moxhk2e0	89	2	56	56	CD
cord-297178-moxhk2e0	89	3	]	]	-RRB-
cord-297178-moxhk2e0	89	4	[	[	-LRB-
cord-297178-moxhk2e0	89	5	57	57	CD
cord-297178-moxhk2e0	89	6	]	]	-RRB-
cord-297178-moxhk2e0	89	7	.	.	.
cord-297178-moxhk2e0	90	1	Interestingly	interestingly	RB
cord-297178-moxhk2e0	90	2	,	,	,
cord-297178-moxhk2e0	90	3	ACE	ACE	NNP
cord-297178-moxhk2e0	90	4	can	can	MD
cord-297178-moxhk2e0	90	5	regulate	regulate	VB
cord-297178-moxhk2e0	90	6	the	the	DT
cord-297178-moxhk2e0	90	7	activity	activity	NN
cord-297178-moxhk2e0	90	8	of	of	IN
cord-297178-moxhk2e0	90	9	ADAM17	ADAM17	NNP
cord-297178-moxhk2e0	90	10	,	,	,
cord-297178-moxhk2e0	90	11	since	since	IN
cord-297178-moxhk2e0	90	12	it	-PRON-	PRP
cord-297178-moxhk2e0	90	13	can	can	MD
cord-297178-moxhk2e0	90	14	be	be	VB
cord-297178-moxhk2e0	90	15	triggered	trigger	VBN
cord-297178-moxhk2e0	90	16	from	from	IN
cord-297178-moxhk2e0	90	17	the	the	DT
cord-297178-moxhk2e0	90	18	activation	activation	NN
cord-297178-moxhk2e0	90	19	of	of	IN
cord-297178-moxhk2e0	90	20	the	the	DT
cord-297178-moxhk2e0	90	21	AT1	AT1	NNP
cord-297178-moxhk2e0	90	22	receptor	receptor	NN
cord-297178-moxhk2e0	90	23	by	by	IN
cord-297178-moxhk2e0	90	24	Ang	Ang	NNP
cord-297178-moxhk2e0	90	25	II	II	NNP
cord-297178-moxhk2e0	90	26	[	[	-LRB-
cord-297178-moxhk2e0	90	27	58	58	CD
cord-297178-moxhk2e0	90	28	]	]	-RRB-
cord-297178-moxhk2e0	90	29	.	.	.
cord-297178-moxhk2e0	91	1	Thus	thus	RB
cord-297178-moxhk2e0	91	2	,	,	,
cord-297178-moxhk2e0	91	3	ACE	ACE	NNP
cord-297178-moxhk2e0	91	4	directly	directly	RB
cord-297178-moxhk2e0	91	5	regulates	regulate	VBZ
cord-297178-moxhk2e0	91	6	the	the	DT
cord-297178-moxhk2e0	91	7	formation	formation	NN
cord-297178-moxhk2e0	91	8	of	of	IN
cord-297178-moxhk2e0	91	9	Ang	Ang	NNP
cord-297178-moxhk2e0	91	10	II	II	NNP
cord-297178-moxhk2e0	91	11	from	from	IN
cord-297178-moxhk2e0	91	12	Ang	Ang	NNP
cord-297178-moxhk2e0	91	13	I	I	NNP
cord-297178-moxhk2e0	91	14	,	,	,
cord-297178-moxhk2e0	91	15	and	and	CC
cord-297178-moxhk2e0	91	16	interferes	interfere	VBZ
cord-297178-moxhk2e0	91	17	via	via	IN
cord-297178-moxhk2e0	91	18	the	the	DT
cord-297178-moxhk2e0	91	19	action	action	NN
cord-297178-moxhk2e0	91	20	of	of	IN
cord-297178-moxhk2e0	91	21	ADAM17	adam17	NN
cord-297178-moxhk2e0	91	22	in	in	IN
cord-297178-moxhk2e0	91	23	ACE2	ACE2	NNP
cord-297178-moxhk2e0	91	24	,	,	,
cord-297178-moxhk2e0	91	25	in	in	IN
cord-297178-moxhk2e0	91	26	the	the	DT
cord-297178-moxhk2e0	91	27	tissue	tissue	NN
cord-297178-moxhk2e0	91	28	formation	formation	NN
cord-297178-moxhk2e0	91	29	of	of	IN
cord-297178-moxhk2e0	91	30	Ang	Ang	NNP
cord-297178-moxhk2e0	91	31	1	1	CD
cord-297178-moxhk2e0	91	32	-	-	SYM
cord-297178-moxhk2e0	91	33	7	7	CD
cord-297178-moxhk2e0	91	34	from	from	IN
cord-297178-moxhk2e0	91	35	Ang	Ang	NNP
cord-297178-moxhk2e0	91	36	II	II	NNP
cord-297178-moxhk2e0	91	37	.	.	.
cord-297178-moxhk2e0	92	1	Therefore	therefore	RB
cord-297178-moxhk2e0	92	2	individuals	individual	NNS
cord-297178-moxhk2e0	92	3	with	with	IN
cord-297178-moxhk2e0	92	4	greater	great	JJR
cord-297178-moxhk2e0	92	5	expression	expression	NN
cord-297178-moxhk2e0	92	6	of	of	IN
cord-297178-moxhk2e0	92	7	tissue	tissue	NN
cord-297178-moxhk2e0	92	8	ACE	ace	NN
cord-297178-moxhk2e0	92	9	,	,	,
cord-297178-moxhk2e0	92	10	and	and	CC
cord-297178-moxhk2e0	92	11	consequently	consequently	RB
cord-297178-moxhk2e0	92	12	,	,	,
cord-297178-moxhk2e0	92	13	greater	great	JJR
cord-297178-moxhk2e0	92	14	production	production	NN
cord-297178-moxhk2e0	92	15	of	of	IN
cord-297178-moxhk2e0	92	16	Ang	Ang	NNP
cord-297178-moxhk2e0	92	17	II	II	NNP
cord-297178-moxhk2e0	92	18	,	,	,
cord-297178-moxhk2e0	92	19	will	will	MD
cord-297178-moxhk2e0	92	20	present	present	VB
cord-297178-moxhk2e0	92	21	a	a	DT
cord-297178-moxhk2e0	92	22	decrease	decrease	NN
cord-297178-moxhk2e0	92	23	in	in	IN
cord-297178-moxhk2e0	92	24	tissue	tissue	NN
cord-297178-moxhk2e0	92	25	ACE2	ACE2	NNP
cord-297178-moxhk2e0	92	26	and	and	CC
cord-297178-moxhk2e0	92	27	an	an	DT
cord-297178-moxhk2e0	92	28	increase	increase	NN
cord-297178-moxhk2e0	92	29	in	in	IN
cord-297178-moxhk2e0	92	30	soluble	soluble	JJ
cord-297178-moxhk2e0	92	31	ACE2	ACE2	NNP
cord-297178-moxhk2e0	92	32	(	(	-LRB-
cord-297178-moxhk2e0	92	33	systemic	systemic	JJ
cord-297178-moxhk2e0	92	34	)	)	-RRB-
cord-297178-moxhk2e0	92	35	,	,	,
cord-297178-moxhk2e0	92	36	due	due	IN
cord-297178-moxhk2e0	92	37	to	to	IN
cord-297178-moxhk2e0	92	38	greater	great	JJR
cord-297178-moxhk2e0	92	39	activation	activation	NN
cord-297178-moxhk2e0	92	40	of	of	IN
cord-297178-moxhk2e0	92	41	ADAM17	ADAM17	NNP
cord-297178-moxhk2e0	92	42	and	and	CC
cord-297178-moxhk2e0	92	43	ACE2	ACE2	NNP
cord-297178-moxhk2e0	92	44	cleavage	cleavage	NN
cord-297178-moxhk2e0	92	45	.	.	.
cord-297178-moxhk2e0	93	1	This	this	DT
cord-297178-moxhk2e0	93	2	interaction	interaction	NN
cord-297178-moxhk2e0	93	3	between	between	IN
cord-297178-moxhk2e0	93	4	ACE	ace	NN
cord-297178-moxhk2e0	93	5	,	,	,
cord-297178-moxhk2e0	93	6	ADAM17	ADAM17	NNP
cord-297178-moxhk2e0	93	7	and	and	CC
cord-297178-moxhk2e0	93	8	ACE2	ACE2	NNP
cord-297178-moxhk2e0	93	9	can	can	MD
cord-297178-moxhk2e0	93	10	explain	explain	VB
cord-297178-moxhk2e0	93	11	the	the	DT
cord-297178-moxhk2e0	93	12	difference	difference	NN
cord-297178-moxhk2e0	93	13	in	in	IN
cord-297178-moxhk2e0	93	14	COVID-19	covid-19	JJ
cord-297178-moxhk2e0	93	15	involvement	involvement	NN
cord-297178-moxhk2e0	93	16	between	between	IN
cord-297178-moxhk2e0	93	17	men	man	NNS
cord-297178-moxhk2e0	93	18	and	and	CC
cord-297178-moxhk2e0	93	19	women	woman	NNS
cord-297178-moxhk2e0	93	20	.	.	.
cord-297178-moxhk2e0	94	1	Androgens	androgen	NNS
cord-297178-moxhk2e0	94	2	increase	increase	VBP
cord-297178-moxhk2e0	94	3	renin	renin	NN
cord-297178-moxhk2e0	94	4	levels	level	NNS
cord-297178-moxhk2e0	94	5	and	and	CC
cord-297178-moxhk2e0	94	6	ACE	ace	NN
cord-297178-moxhk2e0	94	7	activity	activity	NN
cord-297178-moxhk2e0	94	8	,	,	,
cord-297178-moxhk2e0	94	9	while	while	IN
cord-297178-moxhk2e0	94	10	estrogen	estrogen	NN
cord-297178-moxhk2e0	94	11	decreases	decrease	VBZ
cord-297178-moxhk2e0	94	12	renin	renin	NN
cord-297178-moxhk2e0	94	13	levels	level	NNS
cord-297178-moxhk2e0	94	14	,	,	,
cord-297178-moxhk2e0	94	15	ACE	ace	NN
cord-297178-moxhk2e0	94	16	activity	activity	NN
cord-297178-moxhk2e0	94	17	,	,	,
cord-297178-moxhk2e0	94	18	and	and	CC
cord-297178-moxhk2e0	94	19	AT1	at1	NN
cord-297178-moxhk2e0	94	20	receptor	receptor	NN
cord-297178-moxhk2e0	94	21	density	density	NN
cord-297178-moxhk2e0	94	22	,	,	,
cord-297178-moxhk2e0	94	23	and	and	CC
cord-297178-moxhk2e0	94	24	is	be	VBZ
cord-297178-moxhk2e0	94	25	also	also	RB
cord-297178-moxhk2e0	94	26	related	relate	VBN
cord-297178-moxhk2e0	94	27	to	to	IN
cord-297178-moxhk2e0	94	28	increased	increase	VBN
cord-297178-moxhk2e0	94	29	levels	level	NNS
cord-297178-moxhk2e0	94	30	of	of	IN
cord-297178-moxhk2e0	94	31	Ang	Ang	NNP
cord-297178-moxhk2e0	94	32	1	1	CD
cord-297178-moxhk2e0	94	33	-	-	SYM
cord-297178-moxhk2e0	94	34	7	7	CD
cord-297178-moxhk2e0	94	35	[	[	-LRB-
cord-297178-moxhk2e0	94	36	59	59	CD
cord-297178-moxhk2e0	94	37	]	]	-RRB-
cord-297178-moxhk2e0	94	38	,	,	,
cord-297178-moxhk2e0	94	39	an	an	DT
cord-297178-moxhk2e0	94	40	important	important	JJ
cord-297178-moxhk2e0	94	41	actor	actor	NN
cord-297178-moxhk2e0	94	42	in	in	IN
cord-297178-moxhk2e0	94	43	the	the	DT
cord-297178-moxhk2e0	94	44	protective	protective	JJ
cord-297178-moxhk2e0	94	45	axis	axis	NN
cord-297178-moxhk2e0	94	46	of	of	IN
cord-297178-moxhk2e0	94	47	RAS	RAS	NNP
cord-297178-moxhk2e0	94	48	.	.	.
cord-297178-moxhk2e0	95	1	This	this	DT
cord-297178-moxhk2e0	95	2	explains	explain	VBZ
cord-297178-moxhk2e0	95	3	the	the	DT
cord-297178-moxhk2e0	95	4	fact	fact	NN
cord-297178-moxhk2e0	95	5	that	that	IN
cord-297178-moxhk2e0	95	6	men	man	NNS
cord-297178-moxhk2e0	95	7	have	have	VBP
cord-297178-moxhk2e0	95	8	higher	high	JJR
cord-297178-moxhk2e0	95	9	circulating	circulate	VBG
cord-297178-moxhk2e0	95	10	(	(	-LRB-
cord-297178-moxhk2e0	95	11	soluble	soluble	JJ
cord-297178-moxhk2e0	95	12	)	)	-RRB-
cord-297178-moxhk2e0	95	13	ACE2	ACE2	NNP
cord-297178-moxhk2e0	95	14	levels	level	NNS
cord-297178-moxhk2e0	95	15	than	than	IN
cord-297178-moxhk2e0	95	16	women	woman	NNS
cord-297178-moxhk2e0	95	17	[	[	-LRB-
cord-297178-moxhk2e0	95	18	60	60	CD
cord-297178-moxhk2e0	95	19	]	]	-RRB-
cord-297178-moxhk2e0	95	20	,	,	,
cord-297178-moxhk2e0	95	21	due	due	IN
cord-297178-moxhk2e0	95	22	to	to	IN
cord-297178-moxhk2e0	95	23	the	the	DT
cord-297178-moxhk2e0	95	24	greater	great	JJR
cord-297178-moxhk2e0	95	25	action	action	NN
cord-297178-moxhk2e0	95	26	of	of	IN
cord-297178-moxhk2e0	95	27	ADAM17	adam17	NN
cord-297178-moxhk2e0	95	28	via	via	IN
cord-297178-moxhk2e0	95	29	androgens	androgen	NNS
cord-297178-moxhk2e0	95	30	/	/	SYM
cord-297178-moxhk2e0	95	31	ECA	ECA	NNP
cord-297178-moxhk2e0	95	32	/	/	SYM
cord-297178-moxhk2e0	95	33	Ang	Ang	NNP
cord-297178-moxhk2e0	95	34	II	II	NNP
cord-297178-moxhk2e0	95	35	/	/	SYM
cord-297178-moxhk2e0	95	36	AT1	at1	NN
cord-297178-moxhk2e0	95	37	.	.	.
cord-297178-moxhk2e0	96	1	Thus	thus	RB
cord-297178-moxhk2e0	96	2	,	,	,
cord-297178-moxhk2e0	96	3	due	due	IN
cord-297178-moxhk2e0	96	4	to	to	IN
cord-297178-moxhk2e0	96	5	higher	high	JJR
cord-297178-moxhk2e0	96	6	levels	level	NNS
cord-297178-moxhk2e0	96	7	of	of	IN
cord-297178-moxhk2e0	96	8	circulating	circulate	VBG
cord-297178-moxhk2e0	96	9	ACE2	ACE2	NNP
cord-297178-moxhk2e0	96	10	,	,	,
cord-297178-moxhk2e0	96	11	men	man	NNS
cord-297178-moxhk2e0	96	12	may	may	MD
cord-297178-moxhk2e0	96	13	present	present	VB
cord-297178-moxhk2e0	96	14	a	a	DT
cord-297178-moxhk2e0	96	15	lower	low	JJR
cord-297178-moxhk2e0	96	16	level	level	NN
cord-297178-moxhk2e0	96	17	of	of	IN
cord-297178-moxhk2e0	96	18	tissue	tissue	NN
cord-297178-moxhk2e0	96	19	ACE2	ACE2	NNP
cord-297178-moxhk2e0	96	20	,	,	,
cord-297178-moxhk2e0	96	21	becoming	become	VBG
cord-297178-moxhk2e0	96	22	more	more	RBR
cord-297178-moxhk2e0	96	23	vulnerable	vulnerable	JJ
cord-297178-moxhk2e0	96	24	to	to	IN
cord-297178-moxhk2e0	96	25	local	local	JJ
cord-297178-moxhk2e0	96	26	SARS	SARS	NNP
cord-297178-moxhk2e0	96	27	imbalance	imbalance	NN
cord-297178-moxhk2e0	96	28	after	after	IN
cord-297178-moxhk2e0	96	29	SARS	SARS	NNP
cord-297178-moxhk2e0	96	30	-	-	HYPH
cord-297178-moxhk2e0	96	31	Cov-2	Cov-2	NNP
cord-297178-moxhk2e0	96	32	infection	infection	NN
cord-297178-moxhk2e0	96	33	.	.	.
cord-297178-moxhk2e0	97	1	This	this	DT
cord-297178-moxhk2e0	97	2	argument	argument	NN
cord-297178-moxhk2e0	97	3	gains	gain	VBZ
cord-297178-moxhk2e0	97	4	more	more	JJR
cord-297178-moxhk2e0	97	5	strength	strength	NN
cord-297178-moxhk2e0	97	6	when	when	WRB
cord-297178-moxhk2e0	97	7	we	-PRON-	PRP
cord-297178-moxhk2e0	97	8	observe	observe	VBP
cord-297178-moxhk2e0	97	9	that	that	IN
cord-297178-moxhk2e0	97	10	children	child	NNS
cord-297178-moxhk2e0	97	11	[	[	-LRB-
cord-297178-moxhk2e0	97	12	61	61	CD
cord-297178-moxhk2e0	97	13	]	]	-RRB-
cord-297178-moxhk2e0	97	14	and	and	CC
cord-297178-moxhk2e0	97	15	the	the	DT
cord-297178-moxhk2e0	97	16	elderly	elderly	JJ
cord-297178-moxhk2e0	97	17	[	[	-LRB-
cord-297178-moxhk2e0	97	18	62	62	CD
cord-297178-moxhk2e0	97	19	]	]	-RRB-
cord-297178-moxhk2e0	97	20	do	do	VBP
cord-297178-moxhk2e0	97	21	not	not	RB
cord-297178-moxhk2e0	97	22	show	show	VB
cord-297178-moxhk2e0	97	23	a	a	DT
cord-297178-moxhk2e0	97	24	difference	difference	NN
cord-297178-moxhk2e0	97	25	in	in	IN
cord-297178-moxhk2e0	97	26	the	the	DT
cord-297178-moxhk2e0	97	27	involvement	involvement	NN
cord-297178-moxhk2e0	97	28	of	of	IN
cord-297178-moxhk2e0	97	29	COVID-19	covid-19	DT
cord-297178-moxhk2e0	97	30	between	between	IN
cord-297178-moxhk2e0	97	31	genders	gender	NNS
cord-297178-moxhk2e0	97	32	,	,	,
cord-297178-moxhk2e0	97	33	probably	probably	RB
cord-297178-moxhk2e0	97	34	due	due	IN
cord-297178-moxhk2e0	97	35	to	to	IN
cord-297178-moxhk2e0	97	36	the	the	DT
cord-297178-moxhk2e0	97	37	lack	lack	NN
cord-297178-moxhk2e0	97	38	of	of	IN
cord-297178-moxhk2e0	97	39	hormonal	hormonal	JJ
cord-297178-moxhk2e0	97	40	interference	interference	NN
cord-297178-moxhk2e0	97	41	before	before	IN
cord-297178-moxhk2e0	97	42	puberty	puberty	NN
cord-297178-moxhk2e0	97	43	and	and	CC
cord-297178-moxhk2e0	97	44	also	also	RB
cord-297178-moxhk2e0	97	45	due	due	IN
cord-297178-moxhk2e0	97	46	to	to	IN
cord-297178-moxhk2e0	97	47	the	the	DT
cord-297178-moxhk2e0	97	48	loss	loss	NN
cord-297178-moxhk2e0	97	49	of	of	IN
cord-297178-moxhk2e0	97	50	protection	protection	NN
cord-297178-moxhk2e0	97	51	from	from	IN
cord-297178-moxhk2e0	97	52	estrogen	estrogen	NN
cord-297178-moxhk2e0	97	53	in	in	IN
cord-297178-moxhk2e0	97	54	women	woman	NNS
cord-297178-moxhk2e0	97	55	after	after	IN
cord-297178-moxhk2e0	97	56	menopause	menopause	NN
cord-297178-moxhk2e0	97	57	.	.	.
cord-297178-moxhk2e0	98	1	show	show	VB
cord-297178-moxhk2e0	98	2	similar	similar	JJ
cord-297178-moxhk2e0	98	3	responses	response	NNS
cord-297178-moxhk2e0	98	4	to	to	IN
cord-297178-moxhk2e0	98	5	the	the	DT
cord-297178-moxhk2e0	98	6	disease	disease	NN
cord-297178-moxhk2e0	98	7	,	,	,
cord-297178-moxhk2e0	98	8	presenting	present	VBG
cord-297178-moxhk2e0	98	9	a	a	DT
cord-297178-moxhk2e0	98	10	great	great	JJ
cord-297178-moxhk2e0	98	11	increase	increase	NN
cord-297178-moxhk2e0	98	12	in	in	IN
cord-297178-moxhk2e0	98	13	the	the	DT
cord-297178-moxhk2e0	98	14	13	13	CD
cord-297178-moxhk2e0	98	15	production	production	NN
cord-297178-moxhk2e0	98	16	of	of	IN
cord-297178-moxhk2e0	98	17	Ang	Ang	NNP
cord-297178-moxhk2e0	98	18	1	1	CD
cord-297178-moxhk2e0	98	19	-	-	SYM
cord-297178-moxhk2e0	98	20	7	7	CD
cord-297178-moxhk2e0	98	21	when	when	WRB
cord-297178-moxhk2e0	98	22	compared	compare	VBN
cord-297178-moxhk2e0	98	23	to	to	IN
cord-297178-moxhk2e0	98	24	the	the	DT
cord-297178-moxhk2e0	98	25	control	control	NN
cord-297178-moxhk2e0	98	26	group	group	NN
cord-297178-moxhk2e0	98	27	[	[	-LRB-
cord-297178-moxhk2e0	98	28	67	67	CD
cord-297178-moxhk2e0	98	29	,	,	,
cord-297178-moxhk2e0	98	30	71	71	CD
cord-297178-moxhk2e0	98	31	]	]	-RRB-
cord-297178-moxhk2e0	98	32	.	.	.
cord-297178-moxhk2e0	99	1	In	in	IN
cord-297178-moxhk2e0	99	2	sick	sick	JJ
cord-297178-moxhk2e0	99	3	adults	adult	NNS
cord-297178-moxhk2e0	99	4	,	,	,
cord-297178-moxhk2e0	99	5	the	the	DT
cord-297178-moxhk2e0	99	6	Ang	Ang	NNP
cord-297178-moxhk2e0	99	7	1	1	CD
cord-297178-moxhk2e0	99	8	-	-	SYM
cord-297178-moxhk2e0	99	9	7	7	CD
cord-297178-moxhk2e0	99	10	level	level	NN
cord-297178-moxhk2e0	99	11	is	be	VBZ
cord-297178-moxhk2e0	99	12	also	also	RB
cord-297178-moxhk2e0	99	13	high	high	JJ
cord-297178-moxhk2e0	99	14	when	when	WRB
cord-297178-moxhk2e0	99	15	compared	compare	VBN
cord-297178-moxhk2e0	99	16	to	to	IN
cord-297178-moxhk2e0	99	17	healthy	healthy	JJ
cord-297178-moxhk2e0	99	18	subjects	subject	NNS
cord-297178-moxhk2e0	99	19	[	[	-LRB-
cord-297178-moxhk2e0	99	20	68	68	CD
cord-297178-moxhk2e0	99	21	,	,	,
cord-297178-moxhk2e0	99	22	69	69	CD
cord-297178-moxhk2e0	99	23	]	]	-RRB-
cord-297178-moxhk2e0	99	24	,	,	,
cord-297178-moxhk2e0	99	25	but	but	CC
cord-297178-moxhk2e0	99	26	the	the	DT
cord-297178-moxhk2e0	99	27	response	response	NN
cord-297178-moxhk2e0	99	28	intensity	intensity	NN
cord-297178-moxhk2e0	99	29	is	be	VBZ
cord-297178-moxhk2e0	99	30	much	much	RB
cord-297178-moxhk2e0	99	31	lower	low	JJR
cord-297178-moxhk2e0	99	32	when	when	WRB
cord-297178-moxhk2e0	99	33	compared	compare	VBN
cord-297178-moxhk2e0	99	34	to	to	IN
cord-297178-moxhk2e0	99	35	dogs	dog	NNS
cord-297178-moxhk2e0	99	36	and	and	CC
cord-297178-moxhk2e0	99	37	 	 	_SP
cord-297178-moxhk2e0	99	38	Covid-19	Covid-19	NNP
cord-297178-moxhk2e0	99	39	brings	bring	VBZ
cord-297178-moxhk2e0	99	40	the	the	DT
cord-297178-moxhk2e0	99	41	world	world	NN
cord-297178-moxhk2e0	99	42	economy	economy	NN
cord-297178-moxhk2e0	99	43	to	to	IN
cord-297178-moxhk2e0	99	44	its	-PRON-	PRP$
cord-297178-moxhk2e0	99	45	knees	knee	NNS
cord-297178-moxhk2e0	99	46	If	if	IN
cord-297178-moxhk2e0	99	47	the	the	DT
cord-297178-moxhk2e0	99	48	world	world	NN
cord-297178-moxhk2e0	99	49	fails	fail	VBZ
cord-297178-moxhk2e0	99	50	to	to	TO
cord-297178-moxhk2e0	99	51	protect	protect	VB
cord-297178-moxhk2e0	99	52	the	the	DT
cord-297178-moxhk2e0	99	53	economy	economy	NN
cord-297178-moxhk2e0	99	54	,	,	,
cord-297178-moxhk2e0	99	55	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	99	56	will	will	MD
cord-297178-moxhk2e0	99	57	damage	damage	VB
cord-297178-moxhk2e0	99	58	health	health	NN
cord-297178-moxhk2e0	99	59	not	not	RB
cord-297178-moxhk2e0	99	60	just	just	RB
cord-297178-moxhk2e0	99	61	now	now	RB
cord-297178-moxhk2e0	99	62	but	but	CC
cord-297178-moxhk2e0	99	63	also	also	RB
cord-297178-moxhk2e0	99	64	in	in	IN
cord-297178-moxhk2e0	99	65	the	the	DT
cord-297178-moxhk2e0	99	66	future	future	NN
cord-297178-moxhk2e0	99	67	Developing	develop	VBG
cord-297178-moxhk2e0	99	68	a	a	DT
cord-297178-moxhk2e0	99	69	sustainable	sustainable	JJ
cord-297178-moxhk2e0	99	70	exit	exit	NN
cord-297178-moxhk2e0	99	71	strategy	strategy	NN
cord-297178-moxhk2e0	99	72	for	for	IN
cord-297178-moxhk2e0	99	73	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	99	74	:	:	:
cord-297178-moxhk2e0	99	75	health	health	NN
cord-297178-moxhk2e0	99	76	,	,	,
cord-297178-moxhk2e0	99	77	economic	economic	JJ
cord-297178-moxhk2e0	99	78	and	and	CC
cord-297178-moxhk2e0	99	79	public	public	JJ
cord-297178-moxhk2e0	99	80	policy	policy	NN
cord-297178-moxhk2e0	99	81	implications	implication	NNS
cord-297178-moxhk2e0	99	82	System	System	NNP
cord-297178-moxhk2e0	99	83	Blockers	Blockers	NNP
cord-297178-moxhk2e0	99	84	and	and	CC
cord-297178-moxhk2e0	99	85	the	the	DT
cord-297178-moxhk2e0	99	86	Risk	Risk	NNP
cord-297178-moxhk2e0	99	87	of	of	IN
cord-297178-moxhk2e0	99	88	Covid-19	Covid-19	NNP
cord-297178-moxhk2e0	99	89	Renin	Renin	NNP
cord-297178-moxhk2e0	99	90	-	-	HYPH
cord-297178-moxhk2e0	99	91	Angiotensin	Angiotensin	NNP
cord-297178-moxhk2e0	99	92	-	-	HYPH
cord-297178-moxhk2e0	99	93	Aldosterone	Aldosterone	NNP
cord-297178-moxhk2e0	99	94	System	System	NNP
cord-297178-moxhk2e0	99	95	Inhibitors	Inhibitors	NNP
cord-297178-moxhk2e0	99	96	in	in	IN
cord-297178-moxhk2e0	99	97	Patients	patient	NNS
cord-297178-moxhk2e0	99	98	with	with	IN
cord-297178-moxhk2e0	99	99	Covid-19	Covid-19	NNP
cord-297178-moxhk2e0	99	100	ACE2	ACE2	NNP
cord-297178-moxhk2e0	99	101	:	:	:
cord-297178-moxhk2e0	99	102	The	the	DT
cord-297178-moxhk2e0	99	103	key	key	JJ
cord-297178-moxhk2e0	99	104	Molecule	Molecule	NNP
cord-297178-moxhk2e0	99	105	for	for	IN
cord-297178-moxhk2e0	99	106	Understanding	understand	VBG
cord-297178-moxhk2e0	99	107	the	the	DT
cord-297178-moxhk2e0	99	108	Pathophysiology	Pathophysiology	NNP
cord-297178-moxhk2e0	99	109	of	of	IN
cord-297178-moxhk2e0	99	110	Severe	severe	JJ
cord-297178-moxhk2e0	99	111	and	and	CC
cord-297178-moxhk2e0	99	112	Critical	Critical	NNP
cord-297178-moxhk2e0	99	113	Conditions	Conditions	NNPS
cord-297178-moxhk2e0	99	114	of	of	IN
cord-297178-moxhk2e0	99	115	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	99	116	:	:	:
cord-297178-moxhk2e0	99	117	Demon	Demon	NNP
cord-297178-moxhk2e0	99	118	or	or	CC
cord-297178-moxhk2e0	99	119	Angel	Angel	NNP
cord-297178-moxhk2e0	99	120	?	?	.
cord-297178-moxhk2e0	100	1	Viruses	Viruses	NNPS
cord-297178-moxhk2e0	100	2	Association	Association	NNP
cord-297178-moxhk2e0	100	3	between	between	IN
cord-297178-moxhk2e0	100	4	reninangiotensin	reninangiotensin	NNP
cord-297178-moxhk2e0	100	5	system	system	NN
cord-297178-moxhk2e0	100	6	inhibitors	inhibitor	NNS
cord-297178-moxhk2e0	100	7	and	and	CC
cord-297178-moxhk2e0	100	8	COVID-19	covid-19	JJ
cord-297178-moxhk2e0	100	9	complications	complication	NNS
cord-297178-moxhk2e0	100	10	Covid-19	covid-19	VBP
cord-297178-moxhk2e0	100	11	:	:	:
cord-297178-moxhk2e0	101	1	the	the	DT
cord-297178-moxhk2e0	101	2	renin	renin	NN
cord-297178-moxhk2e0	101	3	-	-	HYPH
cord-297178-moxhk2e0	101	4	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	101	5	system	system	NN
cord-297178-moxhk2e0	101	6	imbalance	imbalance	NN
cord-297178-moxhk2e0	101	7	hypothesis	hypothesis	NN
cord-297178-moxhk2e0	102	1	Renin	renin	NN
cord-297178-moxhk2e0	102	2	-	-	HYPH
cord-297178-moxhk2e0	102	3	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	102	4	system	system	NN
cord-297178-moxhk2e0	102	5	revisited	revisit	VBD
cord-297178-moxhk2e0	102	6	A	a	DT
cord-297178-moxhk2e0	102	7	novel	novel	JJ
cord-297178-moxhk2e0	102	8	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	102	9	-	-	HYPH
cord-297178-moxhk2e0	102	10	converting	convert	VBG
cord-297178-moxhk2e0	102	11	enzyme	enzyme	NN
cord-297178-moxhk2e0	102	12	-	-	HYPH
cord-297178-moxhk2e0	102	13	related	relate	VBN
cord-297178-moxhk2e0	102	14	carboxypeptidase	carboxypeptidase	NN
cord-297178-moxhk2e0	102	15	(	(	-LRB-
cord-297178-moxhk2e0	102	16	ACE2	ACE2	NNP
cord-297178-moxhk2e0	102	17	)	)	-RRB-
cord-297178-moxhk2e0	102	18	converts	convert	VBZ
cord-297178-moxhk2e0	102	19	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	102	20	I	-PRON-	PRP
cord-297178-moxhk2e0	102	21	to	to	IN
cord-297178-moxhk2e0	102	22	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	102	23	1	1	CD
cord-297178-moxhk2e0	103	1	-9	-9	NNP
cord-297178-moxhk2e0	103	2	ACEH	ACEH	NNP
cord-297178-moxhk2e0	103	3	/	/	SYM
cord-297178-moxhk2e0	103	4	ACE2	ACE2	NNP
cord-297178-moxhk2e0	103	5	is	be	VBZ
cord-297178-moxhk2e0	103	6	a	a	DT
cord-297178-moxhk2e0	103	7	novel	novel	JJ
cord-297178-moxhk2e0	103	8	mammalian	mammalian	JJ
cord-297178-moxhk2e0	103	9	metallocarboxypeptidase	metallocarboxypeptidase	NN
cord-297178-moxhk2e0	103	10	and	and	CC
cord-297178-moxhk2e0	103	11	a	a	DT
cord-297178-moxhk2e0	103	12	homologue	homologue	NN
cord-297178-moxhk2e0	103	13	of	of	IN
cord-297178-moxhk2e0	103	14	angiotensinconverting	angiotensinconverte	VBG
cord-297178-moxhk2e0	103	15	enzyme	enzyme	NN
cord-297178-moxhk2e0	103	16	insensitive	insensitive	JJ
cord-297178-moxhk2e0	103	17	to	to	IN
cord-297178-moxhk2e0	103	18	ACE	ace	NN
cord-297178-moxhk2e0	103	19	inhibitors	inhibitor	NNS
cord-297178-moxhk2e0	104	1	Ectodomain	ectodomain	NN
cord-297178-moxhk2e0	104	2	shedding	shedding	NN
cord-297178-moxhk2e0	104	3	of	of	IN
cord-297178-moxhk2e0	104	4	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	104	5	converting	convert	VBG
cord-297178-moxhk2e0	104	6	enzyme	enzyme	NN
cord-297178-moxhk2e0	104	7	2	2	CD
cord-297178-moxhk2e0	104	8	in	in	IN
cord-297178-moxhk2e0	104	9	human	human	JJ
cord-297178-moxhk2e0	104	10	airway	airway	NN
cord-297178-moxhk2e0	104	11	epithelia	epithelium	NNS
cord-297178-moxhk2e0	104	12	Angiotensin-(1	Angiotensin-(1	NNP
cord-297178-moxhk2e0	104	13	-	-	HYPH
cord-297178-moxhk2e0	104	14	7	7	CD
cord-297178-moxhk2e0	104	15	)	)	-RRB-
cord-297178-moxhk2e0	104	16	is	be	VBZ
cord-297178-moxhk2e0	104	17	an	an	DT
cord-297178-moxhk2e0	104	18	endogenous	endogenous	JJ
cord-297178-moxhk2e0	104	19	ligand	ligand	NN
cord-297178-moxhk2e0	104	20	for	for	IN
cord-297178-moxhk2e0	104	21	the	the	DT
cord-297178-moxhk2e0	104	22	G	G	NNP
cord-297178-moxhk2e0	104	23	protein	protein	NN
cord-297178-moxhk2e0	104	24	-	-	HYPH
cord-297178-moxhk2e0	104	25	coupled	couple	VBN
cord-297178-moxhk2e0	104	26	receptor	receptor	NN
cord-297178-moxhk2e0	104	27	Mas	Mas	NNP
cord-297178-moxhk2e0	104	28	Renin	Renin	NNP
cord-297178-moxhk2e0	104	29	-	-	HYPH
cord-297178-moxhk2e0	104	30	Angiotensin	Angiotensin	NNP
cord-297178-moxhk2e0	104	31	-	-	HYPH
cord-297178-moxhk2e0	104	32	Aldosterone	Aldosterone	NNP
cord-297178-moxhk2e0	104	33	System	System	NNP
cord-297178-moxhk2e0	104	34	Inhibitors	Inhibitors	NNP
cord-297178-moxhk2e0	104	35	in	in	IN
cord-297178-moxhk2e0	104	36	Covid-19	covid-19	NN
cord-297178-moxhk2e0	104	37	.	.	.
cord-297178-moxhk2e0	104	38	Reply	Reply	NNP
cord-297178-moxhk2e0	104	39	Mechanisms	Mechanisms	NNPS
cord-297178-moxhk2e0	104	40	of	of	IN
cord-297178-moxhk2e0	104	41	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	104	42	cell	cell	NN
cord-297178-moxhk2e0	104	43	entry	entry	NN
cord-297178-moxhk2e0	104	44	mediated	mediate	VBN
cord-297178-moxhk2e0	104	45	by	by	IN
cord-297178-moxhk2e0	104	46	the	the	DT
cord-297178-moxhk2e0	104	47	viral	viral	JJ
cord-297178-moxhk2e0	104	48	spike	spike	NN
cord-297178-moxhk2e0	104	49	protein	protein	NN
cord-297178-moxhk2e0	104	50	Entry	Entry	NNP
cord-297178-moxhk2e0	104	51	of	of	IN
cord-297178-moxhk2e0	104	52	Human	Human	NNP
cord-297178-moxhk2e0	104	53	Coronavirus	Coronavirus	NNP
cord-297178-moxhk2e0	104	54	NL63	NL63	NNP
cord-297178-moxhk2e0	104	55	into	into	IN
cord-297178-moxhk2e0	104	56	the	the	DT
cord-297178-moxhk2e0	104	57	Cell	Cell	NNP
cord-297178-moxhk2e0	104	58	Efficient	efficient	JJ
cord-297178-moxhk2e0	104	59	activation	activation	NN
cord-297178-moxhk2e0	104	60	of	of	IN
cord-297178-moxhk2e0	104	61	the	the	DT
cord-297178-moxhk2e0	104	62	severe	severe	JJ
cord-297178-moxhk2e0	104	63	acute	acute	JJ
cord-297178-moxhk2e0	104	64	respiratory	respiratory	JJ
cord-297178-moxhk2e0	104	65	syndrome	syndrome	NN
cord-297178-moxhk2e0	104	66	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	104	67	spike	spike	NN
cord-297178-moxhk2e0	104	68	18	18	CD
cord-297178-moxhk2e0	104	69	protein	protein	NN
cord-297178-moxhk2e0	104	70	by	by	IN
cord-297178-moxhk2e0	104	71	the	the	DT
cord-297178-moxhk2e0	104	72	transmembrane	transmembrane	NNP
cord-297178-moxhk2e0	104	73	protease	protease	NN
cord-297178-moxhk2e0	104	74	TMPRSS2	TMPRSS2	NNP
cord-297178-moxhk2e0	104	75	Coronavirus	Coronavirus	NNP
cord-297178-moxhk2e0	104	76	membrane	membrane	NN
cord-297178-moxhk2e0	104	77	fusion	fusion	NN
cord-297178-moxhk2e0	104	78	mechanism	mechanism	NN
cord-297178-moxhk2e0	104	79	offers	offer	VBZ
cord-297178-moxhk2e0	104	80	a	a	DT
cord-297178-moxhk2e0	104	81	potential	potential	JJ
cord-297178-moxhk2e0	104	82	target	target	NN
cord-297178-moxhk2e0	104	83	for	for	IN
cord-297178-moxhk2e0	104	84	antiviral	antiviral	JJ
cord-297178-moxhk2e0	104	85	development	development	NN
cord-297178-moxhk2e0	104	86	Clinical	clinical	JJ
cord-297178-moxhk2e0	104	87	progression	progression	NN
cord-297178-moxhk2e0	104	88	and	and	CC
cord-297178-moxhk2e0	104	89	viral	viral	JJ
cord-297178-moxhk2e0	104	90	load	load	NN
cord-297178-moxhk2e0	104	91	in	in	IN
cord-297178-moxhk2e0	104	92	a	a	DT
cord-297178-moxhk2e0	104	93	community	community	NN
cord-297178-moxhk2e0	104	94	outbreak	outbreak	NN
cord-297178-moxhk2e0	104	95	of	of	IN
cord-297178-moxhk2e0	104	96	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	104	97	-	-	HYPH
cord-297178-moxhk2e0	104	98	associated	associate	VBN
cord-297178-moxhk2e0	104	99	SARS	SARS	NNP
cord-297178-moxhk2e0	104	100	pneumonia	pneumonia	NN
cord-297178-moxhk2e0	104	101	:	:	:
cord-297178-moxhk2e0	105	1	a	a	DT
cord-297178-moxhk2e0	105	2	prospective	prospective	JJ
cord-297178-moxhk2e0	105	3	study	study	NN
cord-297178-moxhk2e0	105	4	Insight	Insight	NNP
cord-297178-moxhk2e0	105	5	into	into	IN
cord-297178-moxhk2e0	105	6	2019	2019	CD
cord-297178-moxhk2e0	105	7	novel	novel	NN
cord-297178-moxhk2e0	105	8	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	106	1	-An	-An	:
cord-297178-moxhk2e0	106	2	updated	update	VBN
cord-297178-moxhk2e0	106	3	interim	interim	JJ
cord-297178-moxhk2e0	106	4	review	review	NN
cord-297178-moxhk2e0	106	5	and	and	CC
cord-297178-moxhk2e0	106	6	lessons	lesson	NNS
cord-297178-moxhk2e0	106	7	from	from	IN
cord-297178-moxhk2e0	106	8	SARS	SARS	NNP
cord-297178-moxhk2e0	106	9	-	-	HYPH
cord-297178-moxhk2e0	106	10	CoV	CoV	NNP
cord-297178-moxhk2e0	106	11	and	and	CC
cord-297178-moxhk2e0	106	12	MERS	MERS	NNP
cord-297178-moxhk2e0	106	13	-	-	HYPH
cord-297178-moxhk2e0	106	14	CoV	CoV	NNP
cord-297178-moxhk2e0	107	1	SARS	SARS	NNP
cord-297178-moxhk2e0	107	2	-	-	HYPH
cord-297178-moxhk2e0	107	3	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	107	4	Viral	Viral	NNP
cord-297178-moxhk2e0	107	5	Load	Load	NNP
cord-297178-moxhk2e0	107	6	in	in	IN
cord-297178-moxhk2e0	107	7	Upper	Upper	NNP
cord-297178-moxhk2e0	107	8	Respiratory	respiratory	JJ
cord-297178-moxhk2e0	107	9	Specimens	specimen	NNS
cord-297178-moxhk2e0	107	10	of	of	IN
cord-297178-moxhk2e0	107	11	Infected	infected	JJ
cord-297178-moxhk2e0	107	12	Patients	Patients	NNPS
cord-297178-moxhk2e0	107	13	Differential	differential	JJ
cord-297178-moxhk2e0	107	14	downregulation	downregulation	NN
cord-297178-moxhk2e0	107	15	of	of	IN
cord-297178-moxhk2e0	107	16	ACE2	ACE2	NNP
cord-297178-moxhk2e0	107	17	by	by	IN
cord-297178-moxhk2e0	107	18	the	the	DT
cord-297178-moxhk2e0	107	19	spike	spike	NN
cord-297178-moxhk2e0	107	20	proteins	protein	NNS
cord-297178-moxhk2e0	107	21	of	of	IN
cord-297178-moxhk2e0	107	22	severe	severe	JJ
cord-297178-moxhk2e0	107	23	acute	acute	JJ
cord-297178-moxhk2e0	107	24	respiratory	respiratory	JJ
cord-297178-moxhk2e0	107	25	syndrome	syndrome	NN
cord-297178-moxhk2e0	107	26	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	107	27	and	and	CC
cord-297178-moxhk2e0	107	28	human	human	JJ
cord-297178-moxhk2e0	107	29	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	108	1	NL63	NL63	NNP
cord-297178-moxhk2e0	108	2	Extreme	Extreme	NNP
cord-297178-moxhk2e0	108	3	genomic	genomic	JJ
cord-297178-moxhk2e0	108	4	CpG	cpg	NN
cord-297178-moxhk2e0	108	5	deficiency	deficiency	NN
cord-297178-moxhk2e0	108	6	in	in	IN
cord-297178-moxhk2e0	108	7	SARS	SARS	NNP
cord-297178-moxhk2e0	108	8	-	-	HYPH
cord-297178-moxhk2e0	108	9	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	108	10	and	and	CC
cord-297178-moxhk2e0	108	11	evasion	evasion	NN
cord-297178-moxhk2e0	108	12	of	of	IN
cord-297178-moxhk2e0	108	13	host	host	NN
cord-297178-moxhk2e0	108	14	antiviral	antiviral	JJ
cord-297178-moxhk2e0	108	15	defense	defense	NN
cord-297178-moxhk2e0	108	16	Comparative	comparative	JJ
cord-297178-moxhk2e0	108	17	replication	replication	NN
cord-297178-moxhk2e0	108	18	and	and	CC
cord-297178-moxhk2e0	108	19	immune	immune	JJ
cord-297178-moxhk2e0	108	20	activation	activation	NN
cord-297178-moxhk2e0	108	21	profiles	profile	NNS
cord-297178-moxhk2e0	108	22	of	of	IN
cord-297178-moxhk2e0	108	23	SARS	SARS	NNP
cord-297178-moxhk2e0	108	24	-	-	HYPH
cord-297178-moxhk2e0	108	25	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	108	26	and	and	CC
cord-297178-moxhk2e0	108	27	SARS	SARS	NNP
cord-297178-moxhk2e0	108	28	-	-	HYPH
cord-297178-moxhk2e0	108	29	CoV	CoV	NNP
cord-297178-moxhk2e0	108	30	in	in	IN
cord-297178-moxhk2e0	108	31	human	human	JJ
cord-297178-moxhk2e0	108	32	lungs	lung	NNS
cord-297178-moxhk2e0	108	33	:	:	:
cord-297178-moxhk2e0	109	1	an	an	DT
cord-297178-moxhk2e0	109	2	ex	ex	FW
cord-297178-moxhk2e0	109	3	vivo	vivo	NN
cord-297178-moxhk2e0	109	4	study	study	NN
cord-297178-moxhk2e0	109	5	with	with	IN
cord-297178-moxhk2e0	109	6	implications	implication	NNS
cord-297178-moxhk2e0	109	7	for	for	IN
cord-297178-moxhk2e0	109	8	the	the	DT
cord-297178-moxhk2e0	109	9	pathogenesis	pathogenesis	NN
cord-297178-moxhk2e0	109	10	of	of	IN
cord-297178-moxhk2e0	109	11	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	109	12	The	the	DT
cord-297178-moxhk2e0	109	13	pivotal	pivotal	JJ
cord-297178-moxhk2e0	109	14	link	link	NN
cord-297178-moxhk2e0	109	15	between	between	IN
cord-297178-moxhk2e0	109	16	ACE2	ACE2	NNP
cord-297178-moxhk2e0	109	17	deficiency	deficiency	NN
cord-297178-moxhk2e0	109	18	and	and	CC
cord-297178-moxhk2e0	109	19	SARS	SARS	NNP
cord-297178-moxhk2e0	109	20	-	-	HYPH
cord-297178-moxhk2e0	109	21	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	109	22	infection	infection	NN
cord-297178-moxhk2e0	109	23	Targeting	target	VBG
cord-297178-moxhk2e0	109	24	the	the	DT
cord-297178-moxhk2e0	109	25	renin	renin	NN
cord-297178-moxhk2e0	109	26	-	-	HYPH
cord-297178-moxhk2e0	109	27	angiotensinaldosterone	angiotensinaldosterone	NN
cord-297178-moxhk2e0	109	28	system	system	NN
cord-297178-moxhk2e0	109	29	in	in	IN
cord-297178-moxhk2e0	109	30	fibrosis	fibrosis	NN
cord-297178-moxhk2e0	109	31	Angiotensin	Angiotensin	NNP
cord-297178-moxhk2e0	109	32	-	-	HYPH
cord-297178-moxhk2e0	109	33	converting	convert	VBG
cord-297178-moxhk2e0	109	34	enzyme	enzyme	NN
cord-297178-moxhk2e0	109	35	2	2	CD
cord-297178-moxhk2e0	109	36	protects	protect	VBZ
cord-297178-moxhk2e0	109	37	from	from	IN
cord-297178-moxhk2e0	109	38	severe	severe	JJ
cord-297178-moxhk2e0	109	39	acute	acute	JJ
cord-297178-moxhk2e0	109	40	lung	lung	NN
cord-297178-moxhk2e0	109	41	failure	failure	NN
cord-297178-moxhk2e0	110	1	Pulmonary	Pulmonary	NNP
cord-297178-moxhk2e0	110	2	Vascular	Vascular	NNP
cord-297178-moxhk2e0	110	3	Thrombosis	Thrombosis	NNP
cord-297178-moxhk2e0	110	4	,	,	,
cord-297178-moxhk2e0	110	5	and	and	CC
cord-297178-moxhk2e0	110	6	Angiogenesis	Angiogenesis	NNP
cord-297178-moxhk2e0	110	7	in	in	IN
cord-297178-moxhk2e0	110	8	Covid-19	Covid-19	NNP
cord-297178-moxhk2e0	110	9	Roles	Roles	NNPS
cord-297178-moxhk2e0	110	10	of	of	IN
cord-297178-moxhk2e0	110	11	RUNX	RUNX	NNP
cord-297178-moxhk2e0	110	12	in	in	IN
cord-297178-moxhk2e0	110	13	Hypoxia	hypoxia	NN
cord-297178-moxhk2e0	110	14	-	-	HYPH
cord-297178-moxhk2e0	110	15	Induced	Induced	NNP
cord-297178-moxhk2e0	110	16	Responses	Responses	NNPS
cord-297178-moxhk2e0	110	17	and	and	CC
cord-297178-moxhk2e0	110	18	Angiogenesis	Angiogenesis	NNP
cord-297178-moxhk2e0	110	19	Hypoxia	Hypoxia	NNP
cord-297178-moxhk2e0	110	20	Inducible	Inducible	NNP
cord-297178-moxhk2e0	110	21	Factor	Factor	NNP
cord-297178-moxhk2e0	110	22	Pathway	Pathway	NNP
cord-297178-moxhk2e0	110	23	and	and	CC
cord-297178-moxhk2e0	110	24	Physiological	Physiological	NNP
cord-297178-moxhk2e0	110	25	Adaptation	Adaptation	NNP
cord-297178-moxhk2e0	110	26	:	:	:
cord-297178-moxhk2e0	110	27	A	a	DT
cord-297178-moxhk2e0	110	28	Cell	Cell	NNP
cord-297178-moxhk2e0	110	29	Survival	Survival	NNP
cord-297178-moxhk2e0	110	30	Pathway	Pathway	NNP
cord-297178-moxhk2e0	110	31	?	?	.
cord-297178-moxhk2e0	111	1	Role	role	NN
cord-297178-moxhk2e0	111	2	of	of	IN
cord-297178-moxhk2e0	111	3	HIF-1alpha	hif-1alpha	NN
cord-297178-moxhk2e0	111	4	in	in	IN
cord-297178-moxhk2e0	111	5	the	the	DT
cord-297178-moxhk2e0	111	6	regulation	regulation	NN
cord-297178-moxhk2e0	111	7	ACE	ACE	NNP
cord-297178-moxhk2e0	111	8	and	and	CC
cord-297178-moxhk2e0	111	9	ACE2	ACE2	NNP
cord-297178-moxhk2e0	111	10	expression	expression	NN
cord-297178-moxhk2e0	111	11	in	in	IN
cord-297178-moxhk2e0	111	12	hypoxic	hypoxic	JJ
cord-297178-moxhk2e0	111	13	human	human	JJ
cord-297178-moxhk2e0	111	14	pulmonary	pulmonary	JJ
cord-297178-moxhk2e0	111	15	artery	artery	NN
cord-297178-moxhk2e0	111	16	smooth	smooth	JJ
cord-297178-moxhk2e0	111	17	muscle	muscle	NN
cord-297178-moxhk2e0	111	18	cells	cell	NNS
cord-297178-moxhk2e0	112	1	MiRNA	MiRNA	.
cord-297178-moxhk2e0	113	1	let-7b	let-7b	NNP
cord-297178-moxhk2e0	113	2	promotes	promote	VBZ
cord-297178-moxhk2e0	113	3	the	the	DT
cord-297178-moxhk2e0	113	4	development	development	NN
cord-297178-moxhk2e0	113	5	of	of	IN
cord-297178-moxhk2e0	113	6	hypoxic	hypoxic	JJ
cord-297178-moxhk2e0	113	7	pulmonary	pulmonary	JJ
cord-297178-moxhk2e0	113	8	hypertension	hypertension	NN
cord-297178-moxhk2e0	113	9	by	by	IN
cord-297178-moxhk2e0	113	10	targeting	target	VBG
cord-297178-moxhk2e0	113	11	ACE2	ACE2	NNP
cord-297178-moxhk2e0	114	1	The	the	DT
cord-297178-moxhk2e0	114	2	trinity	trinity	NN
cord-297178-moxhk2e0	114	3	of	of	IN
cord-297178-moxhk2e0	114	4	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	114	5	:	:	:
cord-297178-moxhk2e0	114	6	immunity	immunity	NN
cord-297178-moxhk2e0	114	7	,	,	,
cord-297178-moxhk2e0	114	8	inflammation	inflammation	NN
cord-297178-moxhk2e0	114	9	and	and	CC
cord-297178-moxhk2e0	114	10	intervention	intervention	NN
cord-297178-moxhk2e0	115	1	The	the	DT
cord-297178-moxhk2e0	115	2	pathogenesis	pathogenesis	NN
cord-297178-moxhk2e0	115	3	and	and	CC
cord-297178-moxhk2e0	115	4	treatment	treatment	NN
cord-297178-moxhk2e0	115	5	of	of	IN
cord-297178-moxhk2e0	115	6	the	the	DT
cord-297178-moxhk2e0	115	7	`	`	``
cord-297178-moxhk2e0	115	8	Cytokine	Cytokine	NNP
cord-297178-moxhk2e0	115	9	Storm	Storm	NNP
cord-297178-moxhk2e0	115	10	'	'	''
cord-297178-moxhk2e0	115	11	in	in	IN
cord-297178-moxhk2e0	115	12	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	115	13	Into	into	IN
cord-297178-moxhk2e0	115	14	the	the	DT
cord-297178-moxhk2e0	115	15	eye	eye	NN
cord-297178-moxhk2e0	115	16	of	of	IN
cord-297178-moxhk2e0	115	17	the	the	DT
cord-297178-moxhk2e0	115	18	cytokine	cytokine	NN
cord-297178-moxhk2e0	115	19	storm	storm	NN
cord-297178-moxhk2e0	115	20	AAV8-Mediated	AAV8-Mediated	NNP
cord-297178-moxhk2e0	115	21	Angiotensin	Angiotensin	NNP
cord-297178-moxhk2e0	115	22	-	-	HYPH
cord-297178-moxhk2e0	115	23	Converting	convert	VBG
cord-297178-moxhk2e0	115	24	Enzyme	Enzyme	NNP
cord-297178-moxhk2e0	115	25	2	2	CD
cord-297178-moxhk2e0	115	26	Gene	Gene	NNP
cord-297178-moxhk2e0	115	27	Delivery	Delivery	NNP
cord-297178-moxhk2e0	115	28	Prevents	prevent	VBZ
cord-297178-moxhk2e0	115	29	Experimental	experimental	JJ
cord-297178-moxhk2e0	115	30	Autoimmune	Autoimmune	NNP
cord-297178-moxhk2e0	115	31	Uveitis	Uveitis	NNP
cord-297178-moxhk2e0	115	32	by	by	IN
cord-297178-moxhk2e0	115	33	Regulating	regulate	VBG
cord-297178-moxhk2e0	115	34	MAPK	MAPK	NNP
cord-297178-moxhk2e0	115	35	,	,	,
cord-297178-moxhk2e0	115	36	NF	nf	NN
cord-297178-moxhk2e0	115	37	-	-	HYPH
cord-297178-moxhk2e0	115	38	κB	κB	NNP
cord-297178-moxhk2e0	115	39	and	and	CC
cord-297178-moxhk2e0	115	40	STAT3	STAT3	NNP
cord-297178-moxhk2e0	115	41	SARS	SARS	NNP
cord-297178-moxhk2e0	115	42	-	-	HYPH
cord-297178-moxhk2e0	115	43	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	115	44	pandemic	pandemic	NN
cord-297178-moxhk2e0	115	45	and	and	CC
cord-297178-moxhk2e0	115	46	research	research	NN
cord-297178-moxhk2e0	115	47	gaps	gap	NNS
cord-297178-moxhk2e0	115	48	:	:	:
cord-297178-moxhk2e0	115	49	Understanding	understand	VBG
cord-297178-moxhk2e0	115	50	SARS	SARS	NNP
cord-297178-moxhk2e0	115	51	-	-	HYPH
cord-297178-moxhk2e0	115	52	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	115	53	interaction	interaction	NN
cord-297178-moxhk2e0	115	54	with	with	IN
cord-297178-moxhk2e0	115	55	the	the	DT
cord-297178-moxhk2e0	115	56	ACE2	ACE2	NNP
cord-297178-moxhk2e0	115	57	receptor	receptor	NN
cord-297178-moxhk2e0	115	58	and	and	CC
cord-297178-moxhk2e0	115	59	implications	implication	NNS
cord-297178-moxhk2e0	115	60	for	for	IN
cord-297178-moxhk2e0	115	61	therapy	therapy	NN
cord-297178-moxhk2e0	115	62	Signaling	signal	VBG
cord-297178-moxhk2e0	115	63	by	by	IN
cord-297178-moxhk2e0	115	64	the	the	DT
cord-297178-moxhk2e0	115	65	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	115	66	-	-	HYPH
cord-297178-moxhk2e0	115	67	converting	convert	VBG
cord-297178-moxhk2e0	115	68	enzyme	enzyme	NN
cord-297178-moxhk2e0	115	69	Role	role	NN
cord-297178-moxhk2e0	115	70	of	of	IN
cord-297178-moxhk2e0	115	71	circulating	circulate	VBG
cord-297178-moxhk2e0	115	72	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	115	73	converting	convert	VBG
cord-297178-moxhk2e0	115	74	enzyme	enzyme	NN
cord-297178-moxhk2e0	115	75	2	2	CD
cord-297178-moxhk2e0	115	76	in	in	IN
cord-297178-moxhk2e0	115	77	left	left	JJ
cord-297178-moxhk2e0	115	78	ventricular	ventricular	JJ
cord-297178-moxhk2e0	115	79	remodeling	remodeling	NN
cord-297178-moxhk2e0	115	80	following	follow	VBG
cord-297178-moxhk2e0	115	81	myocardial	myocardial	JJ
cord-297178-moxhk2e0	115	82	infarction	infarction	NN
cord-297178-moxhk2e0	115	83	:	:	:
cord-297178-moxhk2e0	115	84	a	a	DT
cord-297178-moxhk2e0	115	85	prospective	prospective	JJ
cord-297178-moxhk2e0	115	86	controlled	control	VBN
cord-297178-moxhk2e0	115	87	study	study	NN
cord-297178-moxhk2e0	115	88	Replication	replication	NN
cord-297178-moxhk2e0	115	89	-	-	HYPH
cord-297178-moxhk2e0	115	90	dependent	dependent	JJ
cord-297178-moxhk2e0	115	91	downregulation	downregulation	NN
cord-297178-moxhk2e0	115	92	of	of	IN
cord-297178-moxhk2e0	115	93	cellular	cellular	JJ
cord-297178-moxhk2e0	115	94	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	115	95	-	-	HYPH
cord-297178-moxhk2e0	115	96	converting	convert	VBG
cord-297178-moxhk2e0	115	97	enzyme	enzyme	NN
cord-297178-moxhk2e0	115	98	2	2	CD
cord-297178-moxhk2e0	115	99	protein	protein	NN
cord-297178-moxhk2e0	115	100	expression	expression	NN
cord-297178-moxhk2e0	115	101	by	by	IN
cord-297178-moxhk2e0	115	102	human	human	JJ
cord-297178-moxhk2e0	115	103	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	115	104	NL63	NL63	NNP
cord-297178-moxhk2e0	115	105	Exogenous	Exogenous	NNP
cord-297178-moxhk2e0	115	106	ACE2	ACE2	NNP
cord-297178-moxhk2e0	115	107	expression	expression	NN
cord-297178-moxhk2e0	115	108	allows	allow	VBZ
cord-297178-moxhk2e0	115	109	refractory	refractory	JJ
cord-297178-moxhk2e0	115	110	cell	cell	NN
cord-297178-moxhk2e0	115	111	lines	line	NNS
cord-297178-moxhk2e0	115	112	to	to	TO
cord-297178-moxhk2e0	115	113	support	support	VB
cord-297178-moxhk2e0	115	114	severe	severe	JJ
cord-297178-moxhk2e0	115	115	acute	acute	JJ
cord-297178-moxhk2e0	115	116	respiratory	respiratory	JJ
cord-297178-moxhk2e0	115	117	syndrome	syndrome	NN
cord-297178-moxhk2e0	115	118	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	115	119	replication	replication	NN
cord-297178-moxhk2e0	115	120	Inhibition	inhibition	NN
cord-297178-moxhk2e0	115	121	of	of	IN
cord-297178-moxhk2e0	115	122	SARS	SARS	NNP
cord-297178-moxhk2e0	115	123	-	-	HYPH
cord-297178-moxhk2e0	115	124	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	115	125	Infections	Infections	NNPS
cord-297178-moxhk2e0	115	126	in	in	IN
cord-297178-moxhk2e0	115	127	Engineered	engineer	VBN
cord-297178-moxhk2e0	115	128	Human	Human	NNP
cord-297178-moxhk2e0	115	129	Tissues	Tissues	NNPS
cord-297178-moxhk2e0	115	130	Using	use	VBG
cord-297178-moxhk2e0	115	131	Clinical	clinical	JJ
cord-297178-moxhk2e0	115	132	-	-	HYPH
cord-297178-moxhk2e0	115	133	Grade	grade	NN
cord-297178-moxhk2e0	115	134	Soluble	soluble	JJ
cord-297178-moxhk2e0	115	135	Human	Human	NNP
cord-297178-moxhk2e0	115	136	ACE2	ACE2	NNP
cord-297178-moxhk2e0	115	137	ACE2	ACE2	NNP
cord-297178-moxhk2e0	115	138	receptor	receptor	NN
cord-297178-moxhk2e0	115	139	expression	expression	NN
cord-297178-moxhk2e0	115	140	and	and	CC
cord-297178-moxhk2e0	115	141	severe	severe	JJ
cord-297178-moxhk2e0	115	142	acute	acute	JJ
cord-297178-moxhk2e0	115	143	respiratory	respiratory	JJ
cord-297178-moxhk2e0	115	144	syndrome	syndrome	NN
cord-297178-moxhk2e0	115	145	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	115	146	infection	infection	NN
cord-297178-moxhk2e0	115	147	depend	depend	VBP
cord-297178-moxhk2e0	115	148	on	on	IN
cord-297178-moxhk2e0	115	149	differentiation	differentiation	NN
cord-297178-moxhk2e0	115	150	of	of	IN
cord-297178-moxhk2e0	115	151	human	human	JJ
cord-297178-moxhk2e0	115	152	airway	airway	NN
cord-297178-moxhk2e0	115	153	epithelia	epithelium	NNS
cord-297178-moxhk2e0	115	154	Endotoxin	Endotoxin	NNP
cord-297178-moxhk2e0	115	155	induces	induce	VBZ
cord-297178-moxhk2e0	115	156	rapid	rapid	JJ
cord-297178-moxhk2e0	115	157	metalloproteinase	metalloproteinase	NN
cord-297178-moxhk2e0	115	158	-	-	HYPH
cord-297178-moxhk2e0	115	159	mediated	mediate	VBN
cord-297178-moxhk2e0	115	160	shedding	shedding	NN
cord-297178-moxhk2e0	115	161	followed	follow	VBN
cord-297178-moxhk2e0	115	162	by	by	IN
cord-297178-moxhk2e0	115	163	up	up	NN
cord-297178-moxhk2e0	115	164	-	-	HYPH
cord-297178-moxhk2e0	115	165	regulation	regulation	NN
cord-297178-moxhk2e0	115	166	of	of	IN
cord-297178-moxhk2e0	115	167	the	the	DT
cord-297178-moxhk2e0	115	168	monocyte	monocyte	NNP
cord-297178-moxhk2e0	115	169	hemoglobin	hemoglobin	NNP
cord-297178-moxhk2e0	115	170	scavenger	scavenger	NN
cord-297178-moxhk2e0	115	171	receptor	receptor	NN
cord-297178-moxhk2e0	115	172	CD163	CD163	NNP
cord-297178-moxhk2e0	115	173	Epidemiological	Epidemiological	NNP
cord-297178-moxhk2e0	115	174	,	,	,
cord-297178-moxhk2e0	115	175	comorbidity	comorbidity	NN
cord-297178-moxhk2e0	115	176	factors	factor	NNS
cord-297178-moxhk2e0	115	177	with	with	IN
cord-297178-moxhk2e0	115	178	severity	severity	NN
cord-297178-moxhk2e0	115	179	and	and	CC
cord-297178-moxhk2e0	115	180	prognosis	prognosis	NN
cord-297178-moxhk2e0	115	181	of	of	IN
cord-297178-moxhk2e0	115	182	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	115	183	:	:	:
cord-297178-moxhk2e0	115	184	a	a	DT
cord-297178-moxhk2e0	115	185	systematic	systematic	JJ
cord-297178-moxhk2e0	115	186	review	review	NN
cord-297178-moxhk2e0	115	187	and	and	CC
cord-297178-moxhk2e0	115	188	meta	meta	NNP
cord-297178-moxhk2e0	115	189	-	-	HYPH
cord-297178-moxhk2e0	115	190	analysis	analysis	NN
cord-297178-moxhk2e0	115	191	Baseline	Baseline	NNP
cord-297178-moxhk2e0	115	192	Chronic	Chronic	NNP
cord-297178-moxhk2e0	115	193	Comorbidity	Comorbidity	NNP
cord-297178-moxhk2e0	115	194	and	and	CC
cord-297178-moxhk2e0	115	195	Mortality	mortality	NN
cord-297178-moxhk2e0	115	196	in	in	IN
cord-297178-moxhk2e0	115	197	Laboratory	Laboratory	NNP
cord-297178-moxhk2e0	115	198	-	-	HYPH
cord-297178-moxhk2e0	115	199	Confirmed	confirm	VBN
cord-297178-moxhk2e0	115	200	COVID-19	COVID-19	.
cord-297178-moxhk2e0	115	201	Cases	case	NNS
cord-297178-moxhk2e0	115	202	:	:	:
cord-297178-moxhk2e0	115	203	Results	result	NNS
cord-297178-moxhk2e0	115	204	from	from	IN
cord-297178-moxhk2e0	115	205	the	the	DT
cord-297178-moxhk2e0	115	206	PRECOVID	PRECOVID	NNP
cord-297178-moxhk2e0	115	207	Study	Study	NNP
cord-297178-moxhk2e0	115	208	in	in	IN
cord-297178-moxhk2e0	115	209	Spain	Spain	NNP
cord-297178-moxhk2e0	115	210	polymorphism	polymorphism	NN
cord-297178-moxhk2e0	115	211	interacts	interact	VBZ
cord-297178-moxhk2e0	115	212	with	with	IN
cord-297178-moxhk2e0	115	213	dietary	dietary	JJ
cord-297178-moxhk2e0	115	214	n-6	n-6	JJ
cord-297178-moxhk2e0	115	215	polyunsaturated	polyunsaturated	JJ
cord-297178-moxhk2e0	115	216	fatty	fatty	JJ
cord-297178-moxhk2e0	115	217	acids	acid	NNS
cord-297178-moxhk2e0	115	218	to	to	TO
cord-297178-moxhk2e0	115	219	modulate	modulate	VB
cord-297178-moxhk2e0	115	220	obesity	obesity	NN
cord-297178-moxhk2e0	115	221	risk	risk	NN
cord-297178-moxhk2e0	115	222	in	in	IN
cord-297178-moxhk2e0	115	223	the	the	DT
cord-297178-moxhk2e0	115	224	Genetics	Genetics	NNP
cord-297178-moxhk2e0	115	225	of	of	IN
cord-297178-moxhk2e0	115	226	Lipid	Lipid	NNP
cord-297178-moxhk2e0	115	227	Lowering	lower	VBG
cord-297178-moxhk2e0	115	228	Drugs	Drugs	NNPS
cord-297178-moxhk2e0	115	229	and	and	CC
cord-297178-moxhk2e0	115	230	Diet	Diet	NNP
cord-297178-moxhk2e0	115	231	Network	Network	NNP
cord-297178-moxhk2e0	115	232	study	study	NN
cord-297178-moxhk2e0	115	233	Role	role	NN
cord-297178-moxhk2e0	115	234	of	of	IN
cord-297178-moxhk2e0	115	235	ADAM17	adam17	NN
cord-297178-moxhk2e0	115	236	in	in	IN
cord-297178-moxhk2e0	115	237	kidney	kidney	NN
cord-297178-moxhk2e0	115	238	disease	disease	NN
cord-297178-moxhk2e0	116	1	A	a	DT
cord-297178-moxhk2e0	116	2	score	score	NN
cord-297178-moxhk2e0	116	3	including	include	VBG
cord-297178-moxhk2e0	116	4	ADAM17	adam17	IN
cord-297178-moxhk2e0	116	5	substrates	substrate	NNS
cord-297178-moxhk2e0	116	6	correlates	correlate	VBZ
cord-297178-moxhk2e0	116	7	to	to	IN
cord-297178-moxhk2e0	116	8	recurring	recur	VBG
cord-297178-moxhk2e0	116	9	cardiovascular	cardiovascular	JJ
cord-297178-moxhk2e0	116	10	event	event	NN
cord-297178-moxhk2e0	116	11	in	in	IN
cord-297178-moxhk2e0	116	12	subjects	subject	NNS
cord-297178-moxhk2e0	116	13	with	with	IN
cord-297178-moxhk2e0	116	14	atherosclerosis	atherosclerosis	NN
cord-297178-moxhk2e0	117	1	The	the	DT
cord-297178-moxhk2e0	117	2	EGFR	EGFR	NNP
cord-297178-moxhk2e0	117	3	-	-	HYPH
cord-297178-moxhk2e0	117	4	ADAM17	ADAM17	NNP
cord-297178-moxhk2e0	117	5	Axis	Axis	NNP
cord-297178-moxhk2e0	117	6	in	in	IN
cord-297178-moxhk2e0	117	7	Chronic	Chronic	NNP
cord-297178-moxhk2e0	117	8	Obstructive	obstructive	JJ
cord-297178-moxhk2e0	117	9	Pulmonary	Pulmonary	NNP
cord-297178-moxhk2e0	117	10	Disease	Disease	NNP
cord-297178-moxhk2e0	117	11	and	and	CC
cord-297178-moxhk2e0	117	12	Cystic	Cystic	NNP
cord-297178-moxhk2e0	117	13	Fibrosis	Fibrosis	NNP
cord-297178-moxhk2e0	117	14	Lung	Lung	NNP
cord-297178-moxhk2e0	117	15	Pathology	Pathology	NNP
cord-297178-moxhk2e0	118	1	The	the	DT
cord-297178-moxhk2e0	118	2	shedding	shedding	JJ
cord-297178-moxhk2e0	118	3	protease	protease	NN
cord-297178-moxhk2e0	118	4	ADAM17	adam17	NN
cord-297178-moxhk2e0	118	5	:	:	:
cord-297178-moxhk2e0	118	6	Physiology	physiology	NN
cord-297178-moxhk2e0	118	7	and	and	CC
cord-297178-moxhk2e0	118	8	pathophysiology	pathophysiology	NN
cord-297178-moxhk2e0	118	9	Tumor	tumor	NN
cord-297178-moxhk2e0	118	10	necrosis	necrosis	NN
cord-297178-moxhk2e0	118	11	factor	factor	NN
cord-297178-moxhk2e0	118	12	-	-	HYPH
cord-297178-moxhk2e0	118	13	alpha	alpha	NN
cord-297178-moxhk2e0	118	14	convertase	convertase	NN
cord-297178-moxhk2e0	118	15	(	(	-LRB-
cord-297178-moxhk2e0	118	16	ADAM17	ADAM17	NNP
cord-297178-moxhk2e0	118	17	)	)	-RRB-
cord-297178-moxhk2e0	118	18	mediates	mediate	VBZ
cord-297178-moxhk2e0	118	19	regulated	regulate	VBN
cord-297178-moxhk2e0	118	20	ectodomain	ectodomain	NN
cord-297178-moxhk2e0	118	21	shedding	shedding	NN
cord-297178-moxhk2e0	118	22	of	of	IN
cord-297178-moxhk2e0	118	23	the	the	DT
cord-297178-moxhk2e0	118	24	severeacute	severeacute	JJ
cord-297178-moxhk2e0	118	25	respiratory	respiratory	JJ
cord-297178-moxhk2e0	118	26	syndrome	syndrome	NN
cord-297178-moxhk2e0	118	27	-	-	HYPH
cord-297178-moxhk2e0	118	28	coronavirus	coronavirus	NN
cord-297178-moxhk2e0	118	29	(	(	-LRB-
cord-297178-moxhk2e0	118	30	SARS	SARS	NNP
cord-297178-moxhk2e0	118	31	-	-	HYPH
cord-297178-moxhk2e0	118	32	CoV	CoV	NNP
cord-297178-moxhk2e0	118	33	)	)	-RRB-
cord-297178-moxhk2e0	118	34	receptor	receptor	NN
cord-297178-moxhk2e0	118	35	,	,	,
cord-297178-moxhk2e0	119	1	angiotensinconverting	angiotensinconverte	VBG
cord-297178-moxhk2e0	119	2	enzyme-2	enzyme-2	NNP
cord-297178-moxhk2e0	120	1	(	(	-LRB-
cord-297178-moxhk2e0	120	2	ACE2	ACE2	NNP
cord-297178-moxhk2e0	120	3	)	)	-RRB-
cord-297178-moxhk2e0	121	1	The	the	DT
cord-297178-moxhk2e0	121	2	secretases	secretase	NNS
cord-297178-moxhk2e0	121	3	that	that	WDT
cord-297178-moxhk2e0	121	4	cleave	cleave	VBP
cord-297178-moxhk2e0	121	5	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	121	6	converting	convert	VBG
cord-297178-moxhk2e0	121	7	enzyme	enzyme	NN
cord-297178-moxhk2e0	121	8	and	and	CC
cord-297178-moxhk2e0	121	9	the	the	DT
cord-297178-moxhk2e0	121	10	amyloid	amyloid	NN
cord-297178-moxhk2e0	121	11	precursor	precursor	NN
cord-297178-moxhk2e0	121	12	protein	protein	NN
cord-297178-moxhk2e0	121	13	are	be	VBP
cord-297178-moxhk2e0	121	14	distinct	distinct	JJ
cord-297178-moxhk2e0	121	15	from	from	IN
cord-297178-moxhk2e0	121	16	tumour	tumour	NN
cord-297178-moxhk2e0	121	17	necrosis	necrosis	NN
cord-297178-moxhk2e0	121	18	factor	factor	NN
cord-297178-moxhk2e0	121	19	-	-	HYPH
cord-297178-moxhk2e0	121	20	alpha	alpha	NN
cord-297178-moxhk2e0	121	21	convertase	convertase	NN
cord-297178-moxhk2e0	121	22	receptor	receptor	NN
cord-297178-moxhk2e0	121	23	signaling	signal	VBG
cord-297178-moxhk2e0	121	24	pathways	pathway	NNS
cord-297178-moxhk2e0	121	25	in	in	IN
cord-297178-moxhk2e0	121	26	the	the	DT
cord-297178-moxhk2e0	121	27	cardiovascular	cardiovascular	JJ
cord-297178-moxhk2e0	121	28	system	system	NN
cord-297178-moxhk2e0	121	29	Gender	gender	NN
cord-297178-moxhk2e0	121	30	and	and	CC
cord-297178-moxhk2e0	121	31	the	the	DT
cord-297178-moxhk2e0	121	32	reninangiotensin	reninangiotensin	JJ
cord-297178-moxhk2e0	121	33	-	-	HYPH
cord-297178-moxhk2e0	121	34	aldosterone	aldosterone	NN
cord-297178-moxhk2e0	121	35	system	system	NN
cord-297178-moxhk2e0	122	1	Circulating	circulate	VBG
cord-297178-moxhk2e0	122	2	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	122	3	-	-	HYPH
cord-297178-moxhk2e0	122	4	converting	convert	VBG
cord-297178-moxhk2e0	122	5	enzyme	enzyme	NN
cord-297178-moxhk2e0	122	6	2	2	CD
cord-297178-moxhk2e0	122	7	activity	activity	NN
cord-297178-moxhk2e0	122	8	in	in	IN
cord-297178-moxhk2e0	122	9	patients	patient	NNS
cord-297178-moxhk2e0	122	10	with	with	IN
cord-297178-moxhk2e0	122	11	chronic	chronic	JJ
cord-297178-moxhk2e0	122	12	kidney	kidney	NN
cord-297178-moxhk2e0	122	13	disease	disease	NN
cord-297178-moxhk2e0	122	14	without	without	IN
cord-297178-moxhk2e0	122	15	previous	previous	JJ
cord-297178-moxhk2e0	122	16	history	history	NN
cord-297178-moxhk2e0	122	17	of	of	IN
cord-297178-moxhk2e0	122	18	cardiovascular	cardiovascular	JJ
cord-297178-moxhk2e0	122	19	disease	disease	NN
cord-297178-moxhk2e0	122	20	Epidemiology	epidemiology	NN
cord-297178-moxhk2e0	122	21	of	of	IN
cord-297178-moxhk2e0	122	22	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	122	23	Among	among	IN
cord-297178-moxhk2e0	122	24	Children	Children	NNP
cord-297178-moxhk2e0	122	25	in	in	IN
cord-297178-moxhk2e0	122	26	China	China	NNP
cord-297178-moxhk2e0	122	27	Patients	Patients	NNPS
cord-297178-moxhk2e0	122	28	With	with	IN
cord-297178-moxhk2e0	122	29	COVID-19	COVID-19	NNP
cord-297178-moxhk2e0	122	30	Aged	Aged	NNP
cord-297178-moxhk2e0	122	31	60	60	CD
cord-297178-moxhk2e0	122	32	Years	Years	NNPS
cord-297178-moxhk2e0	122	33	and	and	CC
cord-297178-moxhk2e0	122	34	Older	old	JJR
cord-297178-moxhk2e0	122	35	in	in	IN
cord-297178-moxhk2e0	122	36	a	a	DT
cord-297178-moxhk2e0	122	37	University	University	NNP
cord-297178-moxhk2e0	122	38	Hospital	Hospital	NNP
cord-297178-moxhk2e0	122	39	in	in	IN
cord-297178-moxhk2e0	122	40	Risks	risk	NNS
cord-297178-moxhk2e0	122	41	to	to	IN
cord-297178-moxhk2e0	122	42	children	child	NNS
cord-297178-moxhk2e0	122	43	during	during	IN
cord-297178-moxhk2e0	122	44	the	the	DT
cord-297178-moxhk2e0	122	45	covid-19	covid-19	CD
cord-297178-moxhk2e0	122	46	pandemic	pandemic	NN
cord-297178-moxhk2e0	122	47	:	:	:
cord-297178-moxhk2e0	123	1	some	some	DT
cord-297178-moxhk2e0	123	2	essential	essential	JJ
cord-297178-moxhk2e0	123	3	epidemiology	epidemiology	NN
cord-297178-moxhk2e0	123	4	COVID-19	COVID-19	,
cord-297178-moxhk2e0	123	5	in	in	IN
cord-297178-moxhk2e0	123	6	children	child	NNS
cord-297178-moxhk2e0	123	7	:	:	:
cord-297178-moxhk2e0	123	8	Epidemiology	epidemiology	NN
cord-297178-moxhk2e0	123	9	,	,	,
cord-297178-moxhk2e0	123	10	presentation	presentation	NN
cord-297178-moxhk2e0	123	11	,	,	,
cord-297178-moxhk2e0	123	12	diagnosis	diagnosis	NN
cord-297178-moxhk2e0	123	13	and	and	CC
cord-297178-moxhk2e0	123	14	management	management	NN
cord-297178-moxhk2e0	123	15	Spike	Spike	NNP
cord-297178-moxhk2e0	123	16	protein	protein	NN
cord-297178-moxhk2e0	123	17	recognition	recognition	NN
cord-297178-moxhk2e0	123	18	of	of	IN
cord-297178-moxhk2e0	123	19	mammalian	mammalian	JJ
cord-297178-moxhk2e0	123	20	ACE2	ACE2	NNP
cord-297178-moxhk2e0	123	21	predicts	predict	VBZ
cord-297178-moxhk2e0	123	22	the	the	DT
cord-297178-moxhk2e0	123	23	host	host	NN
cord-297178-moxhk2e0	123	24	range	range	NN
cord-297178-moxhk2e0	123	25	and	and	CC
cord-297178-moxhk2e0	123	26	an	an	DT
cord-297178-moxhk2e0	123	27	optimized	optimize	VBN
cord-297178-moxhk2e0	123	28	ACE2	ACE2	NNP
cord-297178-moxhk2e0	123	29	for	for	IN
cord-297178-moxhk2e0	123	30	SARS	SARS	NNP
cord-297178-moxhk2e0	123	31	-	-	HYPH
cord-297178-moxhk2e0	123	32	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	123	33	infection	infection	NN
cord-297178-moxhk2e0	123	34	Infection	infection	NN
cord-297178-moxhk2e0	123	35	of	of	IN
cord-297178-moxhk2e0	123	36	dogs	dog	NNS
cord-297178-moxhk2e0	123	37	with	with	IN
cord-297178-moxhk2e0	123	38	SARS	SARS	NNP
cord-297178-moxhk2e0	123	39	-	-	HYPH
cord-297178-moxhk2e0	123	40	CoV-2	CoV-2	NNP
cord-297178-moxhk2e0	123	41	Suessenbach	Suessenbach	NNP
cord-297178-moxhk2e0	123	42	FK	FK	NNP
cord-297178-moxhk2e0	123	43	,	,	,
cord-297178-moxhk2e0	123	44	Burckhardt	Burckhardt	NNP
cord-297178-moxhk2e0	123	45	BB	BB	NNP
cord-297178-moxhk2e0	123	46	.	.	.
cord-297178-moxhk2e0	124	1	Levels	level	NNS
cord-297178-moxhk2e0	124	2	of	of	IN
cord-297178-moxhk2e0	124	3	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	124	4	peptides	peptide	NNS
cord-297178-moxhk2e0	124	5	in	in	IN
cord-297178-moxhk2e0	124	6	healthy	healthy	JJ
cord-297178-moxhk2e0	124	7	and	and	CC
cord-297178-moxhk2e0	124	8	cardiovascular	cardiovascular	JJ
cord-297178-moxhk2e0	124	9	/	/	SYM
cord-297178-moxhk2e0	124	10	renal	renal	JJ
cord-297178-moxhk2e0	124	11	-	-	HYPH
cord-297178-moxhk2e0	124	12	diseased	diseased	JJ
cord-297178-moxhk2e0	124	13	paediatric	paediatric	JJ
cord-297178-moxhk2e0	124	14	population	population	NN
cord-297178-moxhk2e0	124	15	-	-	,
cord-297178-moxhk2e0	124	16	an	an	DT
cord-297178-moxhk2e0	124	17	investigative	investigative	JJ
cord-297178-moxhk2e0	124	18	review	review	NN
cord-297178-moxhk2e0	124	19	Relationship	relationship	NN
cord-297178-moxhk2e0	124	20	between	between	IN
cord-297178-moxhk2e0	124	21	circulating	circulate	VBG
cord-297178-moxhk2e0	124	22	levels	level	NNS
cord-297178-moxhk2e0	124	23	of	of	IN
cord-297178-moxhk2e0	124	24	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	124	25	-	-	HYPH
cord-297178-moxhk2e0	124	26	converting	convert	VBG
cord-297178-moxhk2e0	124	27	enzyme	enzyme	NN
cord-297178-moxhk2e0	124	28	2-angiotensin-(1	2-angiotensin-(1	CD
cord-297178-moxhk2e0	124	29	-	-	:
cord-297178-moxhk2e0	124	30	7)-MAS	7)-mas	DT
cord-297178-moxhk2e0	124	31	axis	axis	NN
cord-297178-moxhk2e0	124	32	and	and	CC
cord-297178-moxhk2e0	124	33	coronary	coronary	JJ
cord-297178-moxhk2e0	124	34	heart	heart	NN
cord-297178-moxhk2e0	124	35	disease	disease	NN
cord-297178-moxhk2e0	124	36	.	.	.
cord-297178-moxhk2e0	125	1	Heart	heart	NN
cord-297178-moxhk2e0	125	2	Vessels	vessel	NNS
cord-297178-moxhk2e0	125	3	Roles	Roles	NNP
cord-297178-moxhk2e0	125	4	of	of	IN
cord-297178-moxhk2e0	125	5	Angiotensin	Angiotensin	NNP
cord-297178-moxhk2e0	125	6	Peptides	Peptides	NNPS
cord-297178-moxhk2e0	125	7	and	and	CC
cord-297178-moxhk2e0	125	8	Recombinant	Recombinant	NNP
cord-297178-moxhk2e0	125	9	Human	Human	NNP
cord-297178-moxhk2e0	125	10	ACE2	ACE2	NNP
cord-297178-moxhk2e0	125	11	in	in	IN
cord-297178-moxhk2e0	125	12	Heart	Heart	NNP
cord-297178-moxhk2e0	125	13	Failure	failure	NN
cord-297178-moxhk2e0	126	1	Circulating	circulate	VBG
cord-297178-moxhk2e0	126	2	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	126	3	converting	convert	VBG
cord-297178-moxhk2e0	126	4	enzyme	enzyme	NN
cord-297178-moxhk2e0	126	5	2	2	CD
cord-297178-moxhk2e0	126	6	activity	activity	NN
cord-297178-moxhk2e0	126	7	as	as	IN
cord-297178-moxhk2e0	126	8	a	a	DT
cord-297178-moxhk2e0	126	9	biomarker	biomarker	NN
cord-297178-moxhk2e0	126	10	of	of	IN
cord-297178-moxhk2e0	126	11	silent	silent	JJ
cord-297178-moxhk2e0	126	12	atherosclerosis	atherosclerosis	NN
cord-297178-moxhk2e0	126	13	in	in	IN
cord-297178-moxhk2e0	126	14	patients	patient	NNS
cord-297178-moxhk2e0	126	15	with	with	IN
cord-297178-moxhk2e0	126	16	chronic	chronic	JJ
cord-297178-moxhk2e0	126	17	kidney	kidney	NN
cord-297178-moxhk2e0	126	18	disease	disease	NN
cord-297178-moxhk2e0	126	19	Plasma	Plasma	NNP
cord-297178-moxhk2e0	126	20	and	and	CC
cord-297178-moxhk2e0	126	21	tissue	tissue	NN
cord-297178-moxhk2e0	126	22	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	126	23	-	-	HYPH
cord-297178-moxhk2e0	126	24	converting	convert	VBG
cord-297178-moxhk2e0	126	25	enzyme	enzyme	NN
cord-297178-moxhk2e0	126	26	2	2	CD
cord-297178-moxhk2e0	126	27	activity	activity	NN
cord-297178-moxhk2e0	126	28	and	and	CC
cord-297178-moxhk2e0	126	29	plasma	plasma	NN
cord-297178-moxhk2e0	126	30	equilibrium	equilibrium	NN
cord-297178-moxhk2e0	126	31	concentrations	concentration	NNS
cord-297178-moxhk2e0	126	32	of	of	IN
cord-297178-moxhk2e0	126	33	angiotensin	angiotensin	NN
cord-297178-moxhk2e0	126	34	peptides	peptide	NNS
cord-297178-moxhk2e0	126	35	in	in	IN
cord-297178-moxhk2e0	126	36	dogs	dog	NNS
cord-297178-moxhk2e0	126	37	with	with	IN
cord-297178-moxhk2e0	126	38	heart	heart	NN
cord-297178-moxhk2e0	126	39	disease	disease	NN
cord-297178-moxhk2e0	127	1	The	the	DT
cord-297178-moxhk2e0	127	2	author	author	NN
cord-297178-moxhk2e0	127	3	has	have	VBZ
cord-297178-moxhk2e0	127	4	no	no	DT
cord-297178-moxhk2e0	127	5	conflict	conflict	NN
cord-297178-moxhk2e0	127	6	of	of	IN
cord-297178-moxhk2e0	127	7	interest	interest	NN
cord-297178-moxhk2e0	127	8	or	or	CC
cord-297178-moxhk2e0	127	9	commercial	commercial	JJ
cord-297178-moxhk2e0	127	10	sponsor	sponsor	NN
cord-297178-moxhk2e0	127	11	for	for	IN
cord-297178-moxhk2e0	127	12	this	this	DT
cord-297178-moxhk2e0	127	13	work	work	NN
cord-297178-moxhk2e0	128	1	Thanks	thank	NNS
cord-297178-moxhk2e0	128	2	to	to	IN
cord-297178-moxhk2e0	128	3	Isabela	Isabela	NNP
cord-297178-moxhk2e0	128	4	Tanuri	Tanuri	NNP
cord-297178-moxhk2e0	128	5	Bessa	Bessa	NNP
cord-297178-moxhk2e0	128	6	for	for	IN
cord-297178-moxhk2e0	128	7	her	-PRON-	PRP$
cord-297178-moxhk2e0	128	8	helpful	helpful	JJ
cord-297178-moxhk2e0	128	9	comments	comment	NNS
cord-297178-moxhk2e0	128	10	.	.	.
cord-297178-moxhk2e0	129	1	Thanks	thank	NNS
cord-297178-moxhk2e0	129	2	also	also	RB
cord-297178-moxhk2e0	129	3	to	to	IN
cord-297178-moxhk2e0	129	4	the	the	DT
cord-297178-moxhk2e0	129	5	researchers	researcher	NNS
cord-297178-moxhk2e0	129	6	from	from	IN
cord-297178-moxhk2e0	129	7	different	different	JJ
cord-297178-moxhk2e0	129	8	knowledge	knowledge	NN
cord-297178-moxhk2e0	129	9	areas	area	NNS
cord-297178-moxhk2e0	129	10	for	for	IN
cord-297178-moxhk2e0	129	11	all	all	DT
cord-297178-moxhk2e0	129	12	their	-PRON-	PRP$
cord-297178-moxhk2e0	129	13	work	work	NN
cord-297178-moxhk2e0	129	14	undertaken	undertake	VBN
cord-297178-moxhk2e0	129	15	as	as	IN
cord-297178-moxhk2e0	129	16	the	the	DT
cord-297178-moxhk2e0	129	17	basis	basis	NN
cord-297178-moxhk2e0	129	18	for	for	IN
cord-297178-moxhk2e0	129	19	the	the	DT
cord-297178-moxhk2e0	129	20	construction	construction	NN
cord-297178-moxhk2e0	129	21	of	of	IN
cord-297178-moxhk2e0	129	22	this	this	DT
cord-297178-moxhk2e0	129	23	article	article	NN
cord-297178-moxhk2e0	129	24	.	.	.
cord-297178-moxhk2e0	130	1	The	the	DT
cord-297178-moxhk2e0	130	2	author	author	NN
cord-297178-moxhk2e0	130	3	has	have	VBZ
cord-297178-moxhk2e0	130	4	no	no	DT
cord-297178-moxhk2e0	130	5	conflict	conflict	NN
cord-297178-moxhk2e0	130	6	of	of	IN
cord-297178-moxhk2e0	130	7	interest	interest	NN
cord-297178-moxhk2e0	130	8	or	or	CC
cord-297178-moxhk2e0	130	9	commercial	commercial	JJ
cord-297178-moxhk2e0	130	10	sponsor	sponsor	NN
cord-297178-moxhk2e0	130	11	for	for	IN
cord-297178-moxhk2e0	130	12	this	this	DT
cord-297178-moxhk2e0	130	13	work	work	NN
cord-297178-moxhk2e0	130	14	.	.	.
cord-297178-moxhk2e0	131	1	16	16	CD
cord-297178-moxhk2e0	131	2	 	 	_SP