id sid tid token lemma pos cord-293860-6kz0iws6 1 1 key key NN cord-293860-6kz0iws6 1 2 : : : cord-293860-6kz0iws6 2 1 cord-293860 cord-293860 NNP cord-293860-6kz0iws6 2 2 - - HYPH cord-293860-6kz0iws6 2 3 6kz0iws6 6kz0iws6 CD cord-293860-6kz0iws6 2 4 authors author NNS cord-293860-6kz0iws6 2 5 : : : cord-293860-6kz0iws6 3 1 Qutayba Qutayba NNP cord-293860-6kz0iws6 3 2 Almerie Almerie NNP cord-293860-6kz0iws6 3 3 , , , cord-293860-6kz0iws6 3 4 Muhammad Muhammad NNP cord-293860-6kz0iws6 3 5 ; ; : cord-293860-6kz0iws6 3 6 Daniel Daniel NNP cord-293860-6kz0iws6 3 7 Kerrigan Kerrigan NNP cord-293860-6kz0iws6 3 8 , , , cord-293860-6kz0iws6 3 9 David David NNP cord-293860-6kz0iws6 3 10 title title NN cord-293860-6kz0iws6 3 11 : : : cord-293860-6kz0iws6 3 12 The the DT cord-293860-6kz0iws6 3 13 Association Association NNP cord-293860-6kz0iws6 3 14 between between IN cord-293860-6kz0iws6 3 15 Obesity Obesity NNP cord-293860-6kz0iws6 3 16 and and CC cord-293860-6kz0iws6 3 17 Poor Poor NNP cord-293860-6kz0iws6 3 18 Outcome Outcome NNP cord-293860-6kz0iws6 3 19 after after IN cord-293860-6kz0iws6 3 20 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 3 21 Indicates indicate VBZ cord-293860-6kz0iws6 3 22 a a DT cord-293860-6kz0iws6 3 23 Potential potential JJ cord-293860-6kz0iws6 3 24 Therapeutic therapeutic JJ cord-293860-6kz0iws6 3 25 Role role NN cord-293860-6kz0iws6 3 26 for for IN cord-293860-6kz0iws6 3 27 Montelukast Montelukast NNP cord-293860-6kz0iws6 3 28 date date NN cord-293860-6kz0iws6 3 29 : : : cord-293860-6kz0iws6 3 30 2020 2020 CD cord-293860-6kz0iws6 3 31 - - HYPH cord-293860-6kz0iws6 3 32 05 05 CD cord-293860-6kz0iws6 3 33 - - HYPH cord-293860-6kz0iws6 3 34 27 27 CD cord-293860-6kz0iws6 3 35 journal journal NN cord-293860-6kz0iws6 3 36 : : : cord-293860-6kz0iws6 4 1 Med Med NNP cord-293860-6kz0iws6 4 2 Hypotheses Hypotheses NNP cord-293860-6kz0iws6 4 3 DOI DOI NNP cord-293860-6kz0iws6 4 4 : : : cord-293860-6kz0iws6 4 5 10.1016 10.1016 CD cord-293860-6kz0iws6 4 6 / / SYM cord-293860-6kz0iws6 4 7 j.mehy.2020.109883 j.mehy.2020.109883 NN cord-293860-6kz0iws6 4 8 sha sha NNP cord-293860-6kz0iws6 4 9 : : : cord-293860-6kz0iws6 4 10 d1cbc62cd5ebb30669dcc01b5b535d880a96be7f d1cbc62cd5ebb30669dcc01b5b535d880a96be7f NNP cord-293860-6kz0iws6 4 11 doc_id doc_id CD cord-293860-6kz0iws6 4 12 : : : cord-293860-6kz0iws6 4 13 293860 293860 CD cord-293860-6kz0iws6 5 1 cord_uid cord_uid NN cord-293860-6kz0iws6 5 2 : : : cord-293860-6kz0iws6 6 1 6kz0iws6 6kz0iws6 CD cord-293860-6kz0iws6 7 1 It -PRON- PRP cord-293860-6kz0iws6 7 2 is be VBZ cord-293860-6kz0iws6 7 3 widely widely RB cord-293860-6kz0iws6 7 4 believed believe VBN cord-293860-6kz0iws6 7 5 that that IN cord-293860-6kz0iws6 7 6 infection infection NN cord-293860-6kz0iws6 7 7 with with IN cord-293860-6kz0iws6 7 8 the the DT cord-293860-6kz0iws6 7 9 SARS SARS NNP cord-293860-6kz0iws6 7 10 - - HYPH cord-293860-6kz0iws6 7 11 CoV2 CoV2 NNP cord-293860-6kz0iws6 7 12 virus virus NN cord-293860-6kz0iws6 7 13 triggers trigger VBZ cord-293860-6kz0iws6 7 14 a a DT cord-293860-6kz0iws6 7 15 disproportionate disproportionate JJ cord-293860-6kz0iws6 7 16 immune immune JJ cord-293860-6kz0iws6 7 17 response response NN cord-293860-6kz0iws6 7 18 which which WDT cord-293860-6kz0iws6 7 19 causes cause VBZ cord-293860-6kz0iws6 7 20 a a DT cord-293860-6kz0iws6 7 21 devastating devastating JJ cord-293860-6kz0iws6 7 22 systemic systemic JJ cord-293860-6kz0iws6 7 23 injury injury NN cord-293860-6kz0iws6 7 24 , , , cord-293860-6kz0iws6 7 25 particularly particularly RB cord-293860-6kz0iws6 7 26 in in IN cord-293860-6kz0iws6 7 27 individuals individual NNS cord-293860-6kz0iws6 7 28 with with IN cord-293860-6kz0iws6 7 29 obesity obesity NN cord-293860-6kz0iws6 7 30 , , , cord-293860-6kz0iws6 7 31 itself -PRON- PRP cord-293860-6kz0iws6 7 32 a a DT cord-293860-6kz0iws6 7 33 chronic chronic JJ cord-293860-6kz0iws6 7 34 , , , cord-293860-6kz0iws6 7 35 multi multi JJ cord-293860-6kz0iws6 7 36 - - JJ cord-293860-6kz0iws6 7 37 organ organ JJ cord-293860-6kz0iws6 7 38 inflammatory inflammatory JJ cord-293860-6kz0iws6 7 39 disease disease NN cord-293860-6kz0iws6 7 40 . . . cord-293860-6kz0iws6 8 1 Immune immune JJ cord-293860-6kz0iws6 8 2 cells cell NNS cord-293860-6kz0iws6 8 3 accumulate accumulate VBP cord-293860-6kz0iws6 8 4 in in IN cord-293860-6kz0iws6 8 5 visceral visceral JJ cord-293860-6kz0iws6 8 6 adipose adipose JJ cord-293860-6kz0iws6 8 7 tissue tissue NN cord-293860-6kz0iws6 8 8 and and CC cord-293860-6kz0iws6 8 9 together together RB cord-293860-6kz0iws6 8 10 with with IN cord-293860-6kz0iws6 8 11 paracrine paracrine JJ cord-293860-6kz0iws6 8 12 adipocytes adipocyte NNS cord-293860-6kz0iws6 8 13 release release VBP cord-293860-6kz0iws6 8 14 a a DT cord-293860-6kz0iws6 8 15 wide wide JJ cord-293860-6kz0iws6 8 16 range range NN cord-293860-6kz0iws6 8 17 of of IN cord-293860-6kz0iws6 8 18 biologically biologically RB cord-293860-6kz0iws6 8 19 active active JJ cord-293860-6kz0iws6 8 20 cytokines cytokine NNS cord-293860-6kz0iws6 8 21 ( ( -LRB- cord-293860-6kz0iws6 8 22 including include VBG cord-293860-6kz0iws6 8 23 IL-1β il-1β ADD cord-293860-6kz0iws6 8 24 , , , cord-293860-6kz0iws6 8 25 IL5 IL5 NNP cord-293860-6kz0iws6 8 26 , , , cord-293860-6kz0iws6 8 27 IL6 il6 NN cord-293860-6kz0iws6 8 28 and and CC cord-293860-6kz0iws6 8 29 IL8 IL8 NNP cord-293860-6kz0iws6 8 30 ) ) -RRB- cord-293860-6kz0iws6 8 31 that that WDT cord-293860-6kz0iws6 8 32 can can MD cord-293860-6kz0iws6 8 33 result result VB cord-293860-6kz0iws6 8 34 in in IN cord-293860-6kz0iws6 8 35 both both DT cord-293860-6kz0iws6 8 36 local local JJ cord-293860-6kz0iws6 8 37 , , , cord-293860-6kz0iws6 8 38 pulmonary pulmonary JJ cord-293860-6kz0iws6 8 39 and and CC cord-293860-6kz0iws6 8 40 systemic systemic JJ cord-293860-6kz0iws6 8 41 inflammation inflammation NN cord-293860-6kz0iws6 8 42 . . . cord-293860-6kz0iws6 9 1 A a DT cord-293860-6kz0iws6 9 2 more more RBR cord-293860-6kz0iws6 9 3 intense intense JJ cord-293860-6kz0iws6 9 4 ‘ ' `` cord-293860-6kz0iws6 9 5 cytokine cytokine NN cord-293860-6kz0iws6 9 6 storm storm NN cord-293860-6kz0iws6 9 7 ’ ' '' cord-293860-6kz0iws6 9 8 is be VBZ cord-293860-6kz0iws6 9 9 postulated postulate VBN cord-293860-6kz0iws6 9 10 as as IN cord-293860-6kz0iws6 9 11 the the DT cord-293860-6kz0iws6 9 12 mechanism mechanism NN cord-293860-6kz0iws6 9 13 behind behind IN cord-293860-6kz0iws6 9 14 the the DT cord-293860-6kz0iws6 9 15 extreme extreme JJ cord-293860-6kz0iws6 9 16 immune immune JJ cord-293860-6kz0iws6 9 17 response response NN cord-293860-6kz0iws6 9 18 seen see VBN cord-293860-6kz0iws6 9 19 in in IN cord-293860-6kz0iws6 9 20 severe severe JJ cord-293860-6kz0iws6 9 21 COVID-19 covid-19 NN cord-293860-6kz0iws6 9 22 . . . cord-293860-6kz0iws6 10 1 It -PRON- PRP cord-293860-6kz0iws6 10 2 is be VBZ cord-293860-6kz0iws6 10 3 striking strike VBG cord-293860-6kz0iws6 10 4 how how WRB cord-293860-6kz0iws6 10 5 dangerous dangerous JJ cord-293860-6kz0iws6 10 6 the the DT cord-293860-6kz0iws6 10 7 combination combination NN cord-293860-6kz0iws6 10 8 of of IN cord-293860-6kz0iws6 10 9 obesity obesity NN cord-293860-6kz0iws6 10 10 and and CC cord-293860-6kz0iws6 10 11 COVID-19 covid-19 NN cord-293860-6kz0iws6 10 12 is be VBZ cord-293860-6kz0iws6 10 13 , , , cord-293860-6kz0iws6 10 14 resulting result VBG cord-293860-6kz0iws6 10 15 in in IN cord-293860-6kz0iws6 10 16 a a DT cord-293860-6kz0iws6 10 17 greater great JJR cord-293860-6kz0iws6 10 18 risk risk NN cord-293860-6kz0iws6 10 19 of of IN cord-293860-6kz0iws6 10 20 ICU ICU NNP cord-293860-6kz0iws6 10 21 admission admission NN cord-293860-6kz0iws6 10 22 and and CC cord-293860-6kz0iws6 10 23 a a DT cord-293860-6kz0iws6 10 24 higher high JJR cord-293860-6kz0iws6 10 25 mortality mortality NN cord-293860-6kz0iws6 10 26 . . . cord-293860-6kz0iws6 11 1 Furthermore furthermore RB cord-293860-6kz0iws6 11 2 , , , cord-293860-6kz0iws6 11 3 patients patient NNS cord-293860-6kz0iws6 11 4 from from IN cord-293860-6kz0iws6 11 5 a a DT cord-293860-6kz0iws6 11 6 BAME BAME NNP cord-293860-6kz0iws6 11 7 background background NN cord-293860-6kz0iws6 11 8 appear appear VBP cord-293860-6kz0iws6 11 9 to to TO cord-293860-6kz0iws6 11 10 have have VB cord-293860-6kz0iws6 11 11 increased increase VBN cord-293860-6kz0iws6 11 12 mortality mortality NN cord-293860-6kz0iws6 11 13 after after IN cord-293860-6kz0iws6 11 14 SARS SARS NNP cord-293860-6kz0iws6 11 15 - - HYPH cord-293860-6kz0iws6 11 16 CoV2 cov2 NN cord-293860-6kz0iws6 11 17 infection infection NN cord-293860-6kz0iws6 11 18 ; ; : cord-293860-6kz0iws6 11 19 they -PRON- PRP cord-293860-6kz0iws6 11 20 also also RB cord-293860-6kz0iws6 11 21 have have VBP cord-293860-6kz0iws6 11 22 a a DT cord-293860-6kz0iws6 11 23 higher high JJR cord-293860-6kz0iws6 11 24 prevalence prevalence NN cord-293860-6kz0iws6 11 25 of of IN cord-293860-6kz0iws6 11 26 central central JJ cord-293860-6kz0iws6 11 27 obesity obesity NN cord-293860-6kz0iws6 11 28 and and CC cord-293860-6kz0iws6 11 29 its -PRON- PRP$ cord-293860-6kz0iws6 11 30 metabolic metabolic JJ cord-293860-6kz0iws6 11 31 complications complication NNS cord-293860-6kz0iws6 11 32 . . . cord-293860-6kz0iws6 12 1 In in IN cord-293860-6kz0iws6 12 2 the the DT cord-293860-6kz0iws6 12 3 absence absence NN cord-293860-6kz0iws6 12 4 of of IN cord-293860-6kz0iws6 12 5 an an DT cord-293860-6kz0iws6 12 6 effective effective JJ cord-293860-6kz0iws6 12 7 vaccine vaccine NN cord-293860-6kz0iws6 12 8 , , , cord-293860-6kz0iws6 12 9 the the DT cord-293860-6kz0iws6 12 10 therapeutic therapeutic JJ cord-293860-6kz0iws6 12 11 potential potential NN cord-293860-6kz0iws6 12 12 of of IN cord-293860-6kz0iws6 12 13 immune immune NN cord-293860-6kz0iws6 12 14 - - HYPH cord-293860-6kz0iws6 12 15 modulating modulate VBG cord-293860-6kz0iws6 12 16 drugs drug NNS cord-293860-6kz0iws6 12 17 is be VBZ cord-293860-6kz0iws6 12 18 a a DT cord-293860-6kz0iws6 12 19 priority priority NN cord-293860-6kz0iws6 12 20 , , , cord-293860-6kz0iws6 12 21 but but CC cord-293860-6kz0iws6 12 22 the the DT cord-293860-6kz0iws6 12 23 development development NN cord-293860-6kz0iws6 12 24 of of IN cord-293860-6kz0iws6 12 25 new new JJ cord-293860-6kz0iws6 12 26 drugs drug NNS cord-293860-6kz0iws6 12 27 is be VBZ cord-293860-6kz0iws6 12 28 expensive expensive JJ cord-293860-6kz0iws6 12 29 and and CC cord-293860-6kz0iws6 12 30 time time NN cord-293860-6kz0iws6 12 31 - - HYPH cord-293860-6kz0iws6 12 32 consuming consume VBG cord-293860-6kz0iws6 12 33 . . . cord-293860-6kz0iws6 13 1 A a DT cord-293860-6kz0iws6 13 2 more more RBR cord-293860-6kz0iws6 13 3 pragmatic pragmatic JJ cord-293860-6kz0iws6 13 4 solution solution NN cord-293860-6kz0iws6 13 5 would would MD cord-293860-6kz0iws6 13 6 be be VB cord-293860-6kz0iws6 13 7 to to TO cord-293860-6kz0iws6 13 8 seek seek VB cord-293860-6kz0iws6 13 9 to to TO cord-293860-6kz0iws6 13 10 repurpose repurpose VB cord-293860-6kz0iws6 13 11 existing existing JJ cord-293860-6kz0iws6 13 12 drugs drug NNS cord-293860-6kz0iws6 13 13 , , , cord-293860-6kz0iws6 13 14 particularly particularly RB cord-293860-6kz0iws6 13 15 those those DT cord-293860-6kz0iws6 13 16 that that WDT cord-293860-6kz0iws6 13 17 might may MD cord-293860-6kz0iws6 13 18 suppress suppress VB cord-293860-6kz0iws6 13 19 the the DT cord-293860-6kz0iws6 13 20 heightened heighten VBN cord-293860-6kz0iws6 13 21 cytokine cytokine NN cord-293860-6kz0iws6 13 22 activity activity NN cord-293860-6kz0iws6 13 23 seen see VBN cord-293860-6kz0iws6 13 24 in in IN cord-293860-6kz0iws6 13 25 obesity obesity NN cord-293860-6kz0iws6 13 26 , , , cord-293860-6kz0iws6 13 27 the the DT cord-293860-6kz0iws6 13 28 major major JJ cord-293860-6kz0iws6 13 29 risk risk NN cord-293860-6kz0iws6 13 30 factor factor NN cord-293860-6kz0iws6 13 31 for for IN cord-293860-6kz0iws6 13 32 a a DT cord-293860-6kz0iws6 13 33 poor poor JJ cord-293860-6kz0iws6 13 34 prognosis prognosis NN cord-293860-6kz0iws6 13 35 in in IN cord-293860-6kz0iws6 13 36 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 13 37 . . . cord-293860-6kz0iws6 14 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 14 2 is be VBZ cord-293860-6kz0iws6 14 3 a a DT cord-293860-6kz0iws6 14 4 cysteinyl cysteinyl NNP cord-293860-6kz0iws6 14 5 leukotriene leukotriene NN cord-293860-6kz0iws6 14 6 receptor receptor NN cord-293860-6kz0iws6 14 7 antagonist antagonist NN cord-293860-6kz0iws6 14 8 licensed license VBN cord-293860-6kz0iws6 14 9 to to TO cord-293860-6kz0iws6 14 10 treat treat VB cord-293860-6kz0iws6 14 11 asthma asthma NN cord-293860-6kz0iws6 14 12 and and CC cord-293860-6kz0iws6 14 13 allergic allergic JJ cord-293860-6kz0iws6 14 14 rhinitis rhinitis NN cord-293860-6kz0iws6 14 15 . . . cord-293860-6kz0iws6 15 1 It -PRON- PRP cord-293860-6kz0iws6 15 2 has have VBZ cord-293860-6kz0iws6 15 3 been be VBN cord-293860-6kz0iws6 15 4 shown show VBN cord-293860-6kz0iws6 15 5 to to TO cord-293860-6kz0iws6 15 6 diminish diminish VB cord-293860-6kz0iws6 15 7 pulmonary pulmonary JJ cord-293860-6kz0iws6 15 8 response response NN cord-293860-6kz0iws6 15 9 to to IN cord-293860-6kz0iws6 15 10 antigen antigen NN cord-293860-6kz0iws6 15 11 , , , cord-293860-6kz0iws6 15 12 tissue tissue NN cord-293860-6kz0iws6 15 13 eosinophilia eosinophilia NN cord-293860-6kz0iws6 15 14 and and CC cord-293860-6kz0iws6 15 15 IL-5 IL-5 NNP cord-293860-6kz0iws6 15 16 expression expression NN cord-293860-6kz0iws6 15 17 in in IN cord-293860-6kz0iws6 15 18 inflammatory inflammatory JJ cord-293860-6kz0iws6 15 19 cells cell NNS cord-293860-6kz0iws6 15 20 . . . cord-293860-6kz0iws6 16 1 It -PRON- PRP cord-293860-6kz0iws6 16 2 has have VBZ cord-293860-6kz0iws6 16 3 also also RB cord-293860-6kz0iws6 16 4 been be VBN cord-293860-6kz0iws6 16 5 shown show VBN cord-293860-6kz0iws6 16 6 to to TO cord-293860-6kz0iws6 16 7 decrease decrease VB cord-293860-6kz0iws6 16 8 elevated elevated JJ cord-293860-6kz0iws6 16 9 levels level NNS cord-293860-6kz0iws6 16 10 of of IN cord-293860-6kz0iws6 16 11 IL-1β il-1β NN cord-293860-6kz0iws6 16 12 and and CC cord-293860-6kz0iws6 16 13 IL8 il8 NN cord-293860-6kz0iws6 16 14 in in IN cord-293860-6kz0iws6 16 15 humans human NNS cord-293860-6kz0iws6 16 16 with with IN cord-293860-6kz0iws6 16 17 viral viral JJ cord-293860-6kz0iws6 16 18 upper upper JJ cord-293860-6kz0iws6 16 19 respiratory respiratory JJ cord-293860-6kz0iws6 16 20 tract tract NN cord-293860-6kz0iws6 16 21 infections infection NNS cord-293860-6kz0iws6 16 22 compared compare VBN cord-293860-6kz0iws6 16 23 with with IN cord-293860-6kz0iws6 16 24 placebo placebo NN cord-293860-6kz0iws6 16 25 - - HYPH cord-293860-6kz0iws6 16 26 treated treat VBN cord-293860-6kz0iws6 16 27 patients patient NNS cord-293860-6kz0iws6 16 28 . . . cord-293860-6kz0iws6 17 1 In in IN cord-293860-6kz0iws6 17 2 addition addition NN cord-293860-6kz0iws6 17 3 , , , cord-293860-6kz0iws6 17 4 in in IN cord-293860-6kz0iws6 17 5 silico silico NN cord-293860-6kz0iws6 17 6 studies study NNS cord-293860-6kz0iws6 17 7 have have VBP cord-293860-6kz0iws6 17 8 demonstrated demonstrate VBN cord-293860-6kz0iws6 17 9 a a DT cord-293860-6kz0iws6 17 10 high high JJ cord-293860-6kz0iws6 17 11 binding bind VBG cord-293860-6kz0iws6 17 12 affinity affinity NN cord-293860-6kz0iws6 17 13 of of IN cord-293860-6kz0iws6 17 14 the the DT cord-293860-6kz0iws6 17 15 montelukast montelukast NN cord-293860-6kz0iws6 17 16 molecule molecule NN cord-293860-6kz0iws6 17 17 to to IN cord-293860-6kz0iws6 17 18 the the DT cord-293860-6kz0iws6 17 19 terminal terminal JJ cord-293860-6kz0iws6 17 20 site site NN cord-293860-6kz0iws6 17 21 of of IN cord-293860-6kz0iws6 17 22 the the DT cord-293860-6kz0iws6 17 23 virus virus NN cord-293860-6kz0iws6 17 24 ’s ’s POS cord-293860-6kz0iws6 17 25 main main JJ cord-293860-6kz0iws6 17 26 protease protease NN cord-293860-6kz0iws6 17 27 enzyme enzyme NN cord-293860-6kz0iws6 17 28 which which WDT cord-293860-6kz0iws6 17 29 is be VBZ cord-293860-6kz0iws6 17 30 needed need VBN cord-293860-6kz0iws6 17 31 for for IN cord-293860-6kz0iws6 17 32 virus virus NN cord-293860-6kz0iws6 17 33 RNA RNA NNP cord-293860-6kz0iws6 17 34 synthesis synthesis NN cord-293860-6kz0iws6 17 35 and and CC cord-293860-6kz0iws6 17 36 replication replication NN cord-293860-6kz0iws6 17 37 . . . cord-293860-6kz0iws6 18 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 18 2 , , , cord-293860-6kz0iws6 18 3 which which WDT cord-293860-6kz0iws6 18 4 is be VBZ cord-293860-6kz0iws6 18 5 cheap cheap JJ cord-293860-6kz0iws6 18 6 , , , cord-293860-6kz0iws6 18 7 safe safe JJ cord-293860-6kz0iws6 18 8 and and CC cord-293860-6kz0iws6 18 9 widely widely RB cord-293860-6kz0iws6 18 10 available available JJ cord-293860-6kz0iws6 18 11 would would MD cord-293860-6kz0iws6 18 12 appear appear VB cord-293860-6kz0iws6 18 13 to to TO cord-293860-6kz0iws6 18 14 have have VB cord-293860-6kz0iws6 18 15 the the DT cord-293860-6kz0iws6 18 16 potential potential NN cord-293860-6kz0iws6 18 17 to to TO cord-293860-6kz0iws6 18 18 be be VB cord-293860-6kz0iws6 18 19 an an DT cord-293860-6kz0iws6 18 20 ideal ideal JJ cord-293860-6kz0iws6 18 21 candidate candidate NN cord-293860-6kz0iws6 18 22 drug drug NN cord-293860-6kz0iws6 18 23 for for IN cord-293860-6kz0iws6 18 24 clinical clinical JJ cord-293860-6kz0iws6 18 25 trials trial NNS cord-293860-6kz0iws6 18 26 , , , cord-293860-6kz0iws6 18 27 particularly particularly RB cord-293860-6kz0iws6 18 28 in in IN cord-293860-6kz0iws6 18 29 early early JJ cord-293860-6kz0iws6 18 30 stage stage NN cord-293860-6kz0iws6 18 31 disease disease NN cord-293860-6kz0iws6 18 32 before before IN cord-293860-6kz0iws6 18 33 irreparable irreparable JJ cord-293860-6kz0iws6 18 34 tissue tissue NN cord-293860-6kz0iws6 18 35 damage damage NN cord-293860-6kz0iws6 18 36 has have VBZ cord-293860-6kz0iws6 18 37 already already RB cord-293860-6kz0iws6 18 38 occurred occur VBN cord-293860-6kz0iws6 18 39 . . . cord-293860-6kz0iws6 19 1 HYPOTHESIS hypothesis NN cord-293860-6kz0iws6 19 2 : : : cord-293860-6kz0iws6 20 1 Through through IN cord-293860-6kz0iws6 20 2 a a DT cord-293860-6kz0iws6 20 3 direct direct JJ cord-293860-6kz0iws6 20 4 anti anti JJ cord-293860-6kz0iws6 20 5 - - JJ cord-293860-6kz0iws6 20 6 viral viral JJ cord-293860-6kz0iws6 20 7 effect effect NN cord-293860-6kz0iws6 20 8 , , , cord-293860-6kz0iws6 20 9 or or CC cord-293860-6kz0iws6 20 10 by by IN cord-293860-6kz0iws6 20 11 suppression suppression NN cord-293860-6kz0iws6 20 12 of of IN cord-293860-6kz0iws6 20 13 heightened heightened JJ cord-293860-6kz0iws6 20 14 cytokine cytokine NN cord-293860-6kz0iws6 20 15 release release NN cord-293860-6kz0iws6 20 16 in in IN cord-293860-6kz0iws6 20 17 response response NN cord-293860-6kz0iws6 20 18 to to IN cord-293860-6kz0iws6 20 19 SARS SARS NNP cord-293860-6kz0iws6 20 20 - - HYPH cord-293860-6kz0iws6 20 21 CoV2 CoV2 NNP cord-293860-6kz0iws6 20 22 , , , cord-293860-6kz0iws6 20 23 montelukast montelukast NNP cord-293860-6kz0iws6 20 24 will will MD cord-293860-6kz0iws6 20 25 reduce reduce VB cord-293860-6kz0iws6 20 26 the the DT cord-293860-6kz0iws6 20 27 severity severity NN cord-293860-6kz0iws6 20 28 of of IN cord-293860-6kz0iws6 20 29 immune immune NN cord-293860-6kz0iws6 20 30 - - HYPH cord-293860-6kz0iws6 20 31 mediated mediate VBN cord-293860-6kz0iws6 20 32 multiorgan multiorgan NN cord-293860-6kz0iws6 20 33 damage damage NN cord-293860-6kz0iws6 20 34 resulting result VBG cord-293860-6kz0iws6 20 35 from from IN cord-293860-6kz0iws6 20 36 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 20 37 , , , cord-293860-6kz0iws6 20 38 particularly particularly RB cord-293860-6kz0iws6 20 39 in in IN cord-293860-6kz0iws6 20 40 patients patient NNS cord-293860-6kz0iws6 20 41 with with IN cord-293860-6kz0iws6 20 42 central central JJ cord-293860-6kz0iws6 20 43 obesity obesity NN cord-293860-6kz0iws6 20 44 and and CC cord-293860-6kz0iws6 20 45 metabolic metabolic JJ cord-293860-6kz0iws6 20 46 syndrome syndrome NN cord-293860-6kz0iws6 20 47 . . . cord-293860-6kz0iws6 21 1 In in IN cord-293860-6kz0iws6 21 2 the the DT cord-293860-6kz0iws6 21 3 absence absence NN cord-293860-6kz0iws6 21 4 of of IN cord-293860-6kz0iws6 21 5 an an DT cord-293860-6kz0iws6 21 6 effective effective JJ cord-293860-6kz0iws6 21 7 vaccine vaccine NN cord-293860-6kz0iws6 21 8 , , , cord-293860-6kz0iws6 21 9 the the DT cord-293860-6kz0iws6 21 10 therapeutic therapeutic JJ cord-293860-6kz0iws6 21 11 potential potential NN cord-293860-6kz0iws6 21 12 of of IN cord-293860-6kz0iws6 21 13 immune immune NN cord-293860-6kz0iws6 21 14 - - HYPH cord-293860-6kz0iws6 21 15 modulating modulate VBG cord-293860-6kz0iws6 21 16 drugs drug NNS cord-293860-6kz0iws6 21 17 is be VBZ cord-293860-6kz0iws6 21 18 a a DT cord-293860-6kz0iws6 21 19 priority priority NN cord-293860-6kz0iws6 21 20 , , , cord-293860-6kz0iws6 21 21 but but CC cord-293860-6kz0iws6 21 22 the the DT cord-293860-6kz0iws6 21 23 development development NN cord-293860-6kz0iws6 21 24 of of IN cord-293860-6kz0iws6 21 25 new new JJ cord-293860-6kz0iws6 21 26 drugs drug NNS cord-293860-6kz0iws6 21 27 is be VBZ cord-293860-6kz0iws6 21 28 expensive expensive JJ cord-293860-6kz0iws6 21 29 and and CC cord-293860-6kz0iws6 21 30 time time NN cord-293860-6kz0iws6 21 31 - - HYPH cord-293860-6kz0iws6 21 32 consuming consume VBG cord-293860-6kz0iws6 21 33 . . . cord-293860-6kz0iws6 22 1 A a DT cord-293860-6kz0iws6 22 2 more more RBR cord-293860-6kz0iws6 22 3 pragmatic pragmatic JJ cord-293860-6kz0iws6 22 4 solution solution NN cord-293860-6kz0iws6 22 5 would would MD cord-293860-6kz0iws6 22 6 be be VB cord-293860-6kz0iws6 22 7 to to TO cord-293860-6kz0iws6 22 8 seek seek VB cord-293860-6kz0iws6 22 9 to to TO cord-293860-6kz0iws6 22 10 repurpose repurpose VB cord-293860-6kz0iws6 22 11 existing existing JJ cord-293860-6kz0iws6 22 12 drugs drug NNS cord-293860-6kz0iws6 22 13 , , , cord-293860-6kz0iws6 22 14 particularly particularly RB cord-293860-6kz0iws6 22 15 those those DT cord-293860-6kz0iws6 22 16 that that WDT cord-293860-6kz0iws6 22 17 might may MD cord-293860-6kz0iws6 22 18 suppress suppress VB cord-293860-6kz0iws6 22 19 the the DT cord-293860-6kz0iws6 22 20 heightened heighten VBN cord-293860-6kz0iws6 22 21 cytokine cytokine NN cord-293860-6kz0iws6 22 22 activity activity NN cord-293860-6kz0iws6 22 23 seen see VBN cord-293860-6kz0iws6 22 24 in in IN cord-293860-6kz0iws6 22 25 obesity obesity NN cord-293860-6kz0iws6 22 26 , , , cord-293860-6kz0iws6 22 27 the the DT cord-293860-6kz0iws6 22 28 major major JJ cord-293860-6kz0iws6 22 29 risk risk NN cord-293860-6kz0iws6 22 30 factor factor NN cord-293860-6kz0iws6 22 31 for for IN cord-293860-6kz0iws6 22 32 a a DT cord-293860-6kz0iws6 22 33 poor poor JJ cord-293860-6kz0iws6 22 34 prognosis prognosis NN cord-293860-6kz0iws6 22 35 in in IN cord-293860-6kz0iws6 22 36 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 22 37 . . . cord-293860-6kz0iws6 23 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 23 2 is be VBZ cord-293860-6kz0iws6 23 3 a a DT cord-293860-6kz0iws6 23 4 cysteinyl cysteinyl NNP cord-293860-6kz0iws6 23 5 leukotriene leukotriene NN cord-293860-6kz0iws6 23 6 receptor receptor NN cord-293860-6kz0iws6 23 7 antagonist antagonist NN cord-293860-6kz0iws6 23 8 licensed license VBN cord-293860-6kz0iws6 23 9 to to TO cord-293860-6kz0iws6 23 10 treat treat VB cord-293860-6kz0iws6 23 11 asthma asthma NN cord-293860-6kz0iws6 23 12 and and CC cord-293860-6kz0iws6 23 13 allergic allergic JJ cord-293860-6kz0iws6 23 14 rhinitis rhinitis NN cord-293860-6kz0iws6 23 15 . . . cord-293860-6kz0iws6 24 1 It -PRON- PRP cord-293860-6kz0iws6 24 2 has have VBZ cord-293860-6kz0iws6 24 3 been be VBN cord-293860-6kz0iws6 24 4 shown show VBN cord-293860-6kz0iws6 24 5 to to TO cord-293860-6kz0iws6 24 6 diminish diminish VB cord-293860-6kz0iws6 24 7 pulmonary pulmonary JJ cord-293860-6kz0iws6 24 8 response response NN cord-293860-6kz0iws6 24 9 to to IN cord-293860-6kz0iws6 24 10 antigen antigen NN cord-293860-6kz0iws6 24 11 , , , cord-293860-6kz0iws6 24 12 tissue tissue NN cord-293860-6kz0iws6 24 13 eosinophilia eosinophilia NN cord-293860-6kz0iws6 24 14 and and CC cord-293860-6kz0iws6 24 15 IL-5 IL-5 NNP cord-293860-6kz0iws6 24 16 expression expression NN cord-293860-6kz0iws6 24 17 in in IN cord-293860-6kz0iws6 24 18 inflammatory inflammatory JJ cord-293860-6kz0iws6 24 19 cells cell NNS cord-293860-6kz0iws6 24 20 . . . cord-293860-6kz0iws6 25 1 It -PRON- PRP cord-293860-6kz0iws6 25 2 has have VBZ cord-293860-6kz0iws6 25 3 also also RB cord-293860-6kz0iws6 25 4 been be VBN cord-293860-6kz0iws6 25 5 shown show VBN cord-293860-6kz0iws6 25 6 to to TO cord-293860-6kz0iws6 25 7 decrease decrease VB cord-293860-6kz0iws6 25 8 elevated elevated JJ cord-293860-6kz0iws6 25 9 levels level NNS cord-293860-6kz0iws6 25 10 of of IN cord-293860-6kz0iws6 25 11 IL-1 IL-1 NNP cord-293860-6kz0iws6 25 12 and and CC cord-293860-6kz0iws6 25 13 IL8 il8 VB cord-293860-6kz0iws6 25 14 in in IN cord-293860-6kz0iws6 25 15 humans human NNS cord-293860-6kz0iws6 25 16 with with IN cord-293860-6kz0iws6 25 17 viral viral JJ cord-293860-6kz0iws6 25 18 upper upper JJ cord-293860-6kz0iws6 25 19 respiratory respiratory JJ cord-293860-6kz0iws6 25 20 tract tract NN cord-293860-6kz0iws6 25 21 infections infection NNS cord-293860-6kz0iws6 25 22 compared compare VBN cord-293860-6kz0iws6 25 23 with with IN cord-293860-6kz0iws6 25 24 placebo placebo NN cord-293860-6kz0iws6 25 25 - - HYPH cord-293860-6kz0iws6 25 26 treated treat VBN cord-293860-6kz0iws6 25 27 patients patient NNS cord-293860-6kz0iws6 25 28 . . . cord-293860-6kz0iws6 26 1 In in IN cord-293860-6kz0iws6 26 2 addition addition NN cord-293860-6kz0iws6 26 3 , , , cord-293860-6kz0iws6 26 4 in in IN cord-293860-6kz0iws6 26 5 silico silico NN cord-293860-6kz0iws6 26 6 studies study NNS cord-293860-6kz0iws6 26 7 have have VBP cord-293860-6kz0iws6 26 8 demonstrated demonstrate VBN cord-293860-6kz0iws6 26 9 a a DT cord-293860-6kz0iws6 26 10 high high JJ cord-293860-6kz0iws6 26 11 binding bind VBG cord-293860-6kz0iws6 26 12 affinity affinity NN cord-293860-6kz0iws6 26 13 of of IN cord-293860-6kz0iws6 26 14 the the DT cord-293860-6kz0iws6 26 15 montelukast montelukast NN cord-293860-6kz0iws6 26 16 molecule molecule NN cord-293860-6kz0iws6 26 17 to to IN cord-293860-6kz0iws6 26 18 the the DT cord-293860-6kz0iws6 26 19 terminal terminal JJ cord-293860-6kz0iws6 26 20 site site NN cord-293860-6kz0iws6 26 21 of of IN cord-293860-6kz0iws6 26 22 the the DT cord-293860-6kz0iws6 26 23 virus virus NN cord-293860-6kz0iws6 26 24 's 's POS cord-293860-6kz0iws6 26 25 main main JJ cord-293860-6kz0iws6 26 26 protease protease NN cord-293860-6kz0iws6 26 27 enzyme enzyme NN cord-293860-6kz0iws6 26 28 which which WDT cord-293860-6kz0iws6 26 29 is be VBZ cord-293860-6kz0iws6 26 30 needed need VBN cord-293860-6kz0iws6 26 31 for for IN cord-293860-6kz0iws6 26 32 virus virus NN cord-293860-6kz0iws6 26 33 RNA RNA NNP cord-293860-6kz0iws6 26 34 synthesis synthesis NN cord-293860-6kz0iws6 26 35 and and CC cord-293860-6kz0iws6 26 36 replication replication NN cord-293860-6kz0iws6 26 37 . . . cord-293860-6kz0iws6 27 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 27 2 , , , cord-293860-6kz0iws6 27 3 which which WDT cord-293860-6kz0iws6 27 4 is be VBZ cord-293860-6kz0iws6 27 5 cheap cheap JJ cord-293860-6kz0iws6 27 6 , , , cord-293860-6kz0iws6 27 7 safe safe JJ cord-293860-6kz0iws6 27 8 and and CC cord-293860-6kz0iws6 27 9 widely widely RB cord-293860-6kz0iws6 27 10 available available JJ cord-293860-6kz0iws6 27 11 would would MD cord-293860-6kz0iws6 27 12 appear appear VB cord-293860-6kz0iws6 27 13 to to TO cord-293860-6kz0iws6 27 14 have have VB cord-293860-6kz0iws6 27 15 the the DT cord-293860-6kz0iws6 27 16 potential potential NN cord-293860-6kz0iws6 27 17 to to TO cord-293860-6kz0iws6 27 18 be be VB cord-293860-6kz0iws6 27 19 an an DT cord-293860-6kz0iws6 27 20 ideal ideal JJ cord-293860-6kz0iws6 27 21 candidate candidate NN cord-293860-6kz0iws6 27 22 drug drug NN cord-293860-6kz0iws6 27 23 for for IN cord-293860-6kz0iws6 27 24 clinical clinical JJ cord-293860-6kz0iws6 27 25 trials trial NNS cord-293860-6kz0iws6 27 26 , , , cord-293860-6kz0iws6 27 27 particularly particularly RB cord-293860-6kz0iws6 27 28 in in IN cord-293860-6kz0iws6 27 29 early early JJ cord-293860-6kz0iws6 27 30 stage stage NN cord-293860-6kz0iws6 27 31 disease disease NN cord-293860-6kz0iws6 27 32 before before IN cord-293860-6kz0iws6 27 33 irreparable irreparable JJ cord-293860-6kz0iws6 27 34 tissue tissue NN cord-293860-6kz0iws6 27 35 damage damage NN cord-293860-6kz0iws6 27 36 has have VBZ cord-293860-6kz0iws6 27 37 already already RB cord-293860-6kz0iws6 27 38 occurred occur VBN cord-293860-6kz0iws6 27 39 . . . cord-293860-6kz0iws6 28 1 Through through IN cord-293860-6kz0iws6 28 2 a a DT cord-293860-6kz0iws6 28 3 direct direct JJ cord-293860-6kz0iws6 28 4 anti anti JJ cord-293860-6kz0iws6 28 5 - - JJ cord-293860-6kz0iws6 28 6 viral viral JJ cord-293860-6kz0iws6 28 7 effect effect NN cord-293860-6kz0iws6 28 8 , , , cord-293860-6kz0iws6 28 9 or or CC cord-293860-6kz0iws6 28 10 by by IN cord-293860-6kz0iws6 28 11 suppression suppression NN cord-293860-6kz0iws6 28 12 of of IN cord-293860-6kz0iws6 28 13 heightened heightened JJ cord-293860-6kz0iws6 28 14 cytokine cytokine NN cord-293860-6kz0iws6 28 15 release release NN cord-293860-6kz0iws6 28 16 in in IN cord-293860-6kz0iws6 28 17 response response NN cord-293860-6kz0iws6 28 18 to to IN cord-293860-6kz0iws6 28 19 SARS SARS NNP cord-293860-6kz0iws6 28 20 - - HYPH cord-293860-6kz0iws6 28 21 CoV2 CoV2 NNP cord-293860-6kz0iws6 28 22 , , , cord-293860-6kz0iws6 28 23 montelukast montelukast NNP cord-293860-6kz0iws6 28 24 will will MD cord-293860-6kz0iws6 28 25 reduce reduce VB cord-293860-6kz0iws6 28 26 the the DT cord-293860-6kz0iws6 28 27 severity severity NN cord-293860-6kz0iws6 28 28 of of IN cord-293860-6kz0iws6 28 29 immune immune NN cord-293860-6kz0iws6 28 30 - - HYPH cord-293860-6kz0iws6 28 31 mediated mediate VBN cord-293860-6kz0iws6 28 32 multiorgan multiorgan NN cord-293860-6kz0iws6 28 33 damage damage NN cord-293860-6kz0iws6 28 34 resulting result VBG cord-293860-6kz0iws6 28 35 from from IN cord-293860-6kz0iws6 28 36 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 28 37 , , , cord-293860-6kz0iws6 28 38 particularly particularly RB cord-293860-6kz0iws6 28 39 in in IN cord-293860-6kz0iws6 28 40 patients patient NNS cord-293860-6kz0iws6 28 41 with with IN cord-293860-6kz0iws6 28 42 central central JJ cord-293860-6kz0iws6 28 43 obesity obesity NN cord-293860-6kz0iws6 28 44 and and CC cord-293860-6kz0iws6 28 45 metabolic metabolic JJ cord-293860-6kz0iws6 28 46 syndrome syndrome NN cord-293860-6kz0iws6 28 47 . . . cord-293860-6kz0iws6 29 1 It -PRON- PRP cord-293860-6kz0iws6 29 2 is be VBZ cord-293860-6kz0iws6 29 3 widely widely RB cord-293860-6kz0iws6 29 4 believed believe VBN cord-293860-6kz0iws6 29 5 that that IN cord-293860-6kz0iws6 29 6 infection infection NN cord-293860-6kz0iws6 29 7 with with IN cord-293860-6kz0iws6 29 8 the the DT cord-293860-6kz0iws6 29 9 SARS SARS NNP cord-293860-6kz0iws6 29 10 - - HYPH cord-293860-6kz0iws6 29 11 CoV2 CoV2 NNP cord-293860-6kz0iws6 29 12 virus virus NN cord-293860-6kz0iws6 29 13 triggers trigger VBZ cord-293860-6kz0iws6 29 14 a a DT cord-293860-6kz0iws6 29 15 disproportionate disproportionate JJ cord-293860-6kz0iws6 29 16 immune immune JJ cord-293860-6kz0iws6 29 17 response response NN cord-293860-6kz0iws6 29 18 which which WDT cord-293860-6kz0iws6 29 19 causes cause VBZ cord-293860-6kz0iws6 29 20 a a DT cord-293860-6kz0iws6 29 21 devastating devastating JJ cord-293860-6kz0iws6 29 22 systemic systemic JJ cord-293860-6kz0iws6 29 23 injury injury NN cord-293860-6kz0iws6 29 24 , , , cord-293860-6kz0iws6 29 25 particularly particularly RB cord-293860-6kz0iws6 29 26 in in IN cord-293860-6kz0iws6 29 27 individuals individual NNS cord-293860-6kz0iws6 29 28 with with IN cord-293860-6kz0iws6 29 29 obesity obesity NN cord-293860-6kz0iws6 29 30 , , , cord-293860-6kz0iws6 29 31 itself -PRON- PRP cord-293860-6kz0iws6 29 32 a a DT cord-293860-6kz0iws6 29 33 chronic chronic JJ cord-293860-6kz0iws6 29 34 , , , cord-293860-6kz0iws6 29 35 multi multi JJ cord-293860-6kz0iws6 29 36 - - JJ cord-293860-6kz0iws6 29 37 organ organ JJ cord-293860-6kz0iws6 29 38 inflammatory inflammatory JJ cord-293860-6kz0iws6 29 39 disease disease NN cord-293860-6kz0iws6 29 40 . . . cord-293860-6kz0iws6 30 1 Immune immune JJ cord-293860-6kz0iws6 30 2 cells cell NNS cord-293860-6kz0iws6 30 3 accumulate accumulate VBP cord-293860-6kz0iws6 30 4 in in IN cord-293860-6kz0iws6 30 5 visceral visceral JJ cord-293860-6kz0iws6 30 6 adipose adipose JJ cord-293860-6kz0iws6 30 7 tissue tissue NN cord-293860-6kz0iws6 30 8 and and CC cord-293860-6kz0iws6 30 9 together together RB cord-293860-6kz0iws6 30 10 with with IN cord-293860-6kz0iws6 30 11 paracrine paracrine JJ cord-293860-6kz0iws6 30 12 adipocytes adipocyte NNS cord-293860-6kz0iws6 30 13 release release VBP cord-293860-6kz0iws6 30 14 a a DT cord-293860-6kz0iws6 30 15 wide wide JJ cord-293860-6kz0iws6 30 16 range range NN cord-293860-6kz0iws6 30 17 of of IN cord-293860-6kz0iws6 30 18 biologically biologically RB cord-293860-6kz0iws6 30 19 active active JJ cord-293860-6kz0iws6 30 20 cytokines cytokine NNS cord-293860-6kz0iws6 30 21 ( ( -LRB- cord-293860-6kz0iws6 30 22 including include VBG cord-293860-6kz0iws6 30 23 IL-1 IL-1 NNP cord-293860-6kz0iws6 30 24 , , , cord-293860-6kz0iws6 30 25 IL5 IL5 NNP cord-293860-6kz0iws6 30 26 , , , cord-293860-6kz0iws6 30 27 IL6 il6 NN cord-293860-6kz0iws6 30 28 and and CC cord-293860-6kz0iws6 30 29 IL8 IL8 NNP cord-293860-6kz0iws6 30 30 ) ) -RRB- cord-293860-6kz0iws6 30 31 that that WDT cord-293860-6kz0iws6 30 32 can can MD cord-293860-6kz0iws6 30 33 result result VB cord-293860-6kz0iws6 30 34 in in IN cord-293860-6kz0iws6 30 35 both both DT cord-293860-6kz0iws6 30 36 local local JJ cord-293860-6kz0iws6 30 37 , , , cord-293860-6kz0iws6 30 38 pulmonary pulmonary JJ cord-293860-6kz0iws6 30 39 and and CC cord-293860-6kz0iws6 30 40 systemic systemic JJ cord-293860-6kz0iws6 30 41 inflammation inflammation NN cord-293860-6kz0iws6 30 42 1 1 CD cord-293860-6kz0iws6 30 43 - - SYM cord-293860-6kz0iws6 30 44 3 3 CD cord-293860-6kz0iws6 30 45 . . . cord-293860-6kz0iws6 31 1 A a DT cord-293860-6kz0iws6 31 2 more more RBR cord-293860-6kz0iws6 31 3 intense intense JJ cord-293860-6kz0iws6 31 4 ' ' `` cord-293860-6kz0iws6 31 5 cytokine cytokine NN cord-293860-6kz0iws6 31 6 storm storm NN cord-293860-6kz0iws6 31 7 ' ' '' cord-293860-6kz0iws6 31 8 is be VBZ cord-293860-6kz0iws6 31 9 postulated postulate VBN cord-293860-6kz0iws6 31 10 as as IN cord-293860-6kz0iws6 31 11 the the DT cord-293860-6kz0iws6 31 12 mechanism mechanism NN cord-293860-6kz0iws6 31 13 behind behind IN cord-293860-6kz0iws6 31 14 the the DT cord-293860-6kz0iws6 31 15 extreme extreme JJ cord-293860-6kz0iws6 31 16 immune immune JJ cord-293860-6kz0iws6 31 17 response response NN cord-293860-6kz0iws6 31 18 seen see VBN cord-293860-6kz0iws6 31 19 in in IN cord-293860-6kz0iws6 31 20 severe severe JJ cord-293860-6kz0iws6 31 21 COVID-19 covid-19 NN cord-293860-6kz0iws6 31 22 . . . cord-293860-6kz0iws6 32 1 It -PRON- PRP cord-293860-6kz0iws6 32 2 is be VBZ cord-293860-6kz0iws6 32 3 striking strike VBG cord-293860-6kz0iws6 32 4 how how WRB cord-293860-6kz0iws6 32 5 dangerous dangerous JJ cord-293860-6kz0iws6 32 6 the the DT cord-293860-6kz0iws6 32 7 combination combination NN cord-293860-6kz0iws6 32 8 of of IN cord-293860-6kz0iws6 32 9 obesity obesity NN cord-293860-6kz0iws6 32 10 and and CC cord-293860-6kz0iws6 32 11 COVID-19 covid-19 NN cord-293860-6kz0iws6 32 12 is be VBZ cord-293860-6kz0iws6 32 13 , , , cord-293860-6kz0iws6 32 14 resulting result VBG cord-293860-6kz0iws6 32 15 in in IN cord-293860-6kz0iws6 32 16 a a DT cord-293860-6kz0iws6 32 17 greater great JJR cord-293860-6kz0iws6 32 18 risk risk NN cord-293860-6kz0iws6 32 19 of of IN cord-293860-6kz0iws6 32 20 ICU ICU NNP cord-293860-6kz0iws6 32 21 admission admission NN cord-293860-6kz0iws6 32 22 and and CC cord-293860-6kz0iws6 32 23 a a DT cord-293860-6kz0iws6 32 24 higher high JJR cord-293860-6kz0iws6 32 25 mortality mortality NN cord-293860-6kz0iws6 32 26 4 4 CD cord-293860-6kz0iws6 32 27 , , , cord-293860-6kz0iws6 32 28 suggesting suggest VBG cord-293860-6kz0iws6 32 29 that that IN cord-293860-6kz0iws6 32 30 the the DT cord-293860-6kz0iws6 32 31 already already RB cord-293860-6kz0iws6 32 32 heightened heighten VBN cord-293860-6kz0iws6 32 33 background background NN cord-293860-6kz0iws6 32 34 inflammatory inflammatory JJ cord-293860-6kz0iws6 32 35 process process NN cord-293860-6kz0iws6 32 36 resulting result VBG cord-293860-6kz0iws6 32 37 from from IN cord-293860-6kz0iws6 32 38 obesity obesity NN cord-293860-6kz0iws6 32 39 might may MD cord-293860-6kz0iws6 32 40 prime prime VB cord-293860-6kz0iws6 32 41 the the DT cord-293860-6kz0iws6 32 42 immune immune JJ cord-293860-6kz0iws6 32 43 system system NN cord-293860-6kz0iws6 32 44 for for IN cord-293860-6kz0iws6 32 45 a a DT cord-293860-6kz0iws6 32 46 more more RBR cord-293860-6kz0iws6 32 47 catastrophic catastrophic JJ cord-293860-6kz0iws6 32 48 response response NN cord-293860-6kz0iws6 32 49 to to IN cord-293860-6kz0iws6 32 50 SAR SAR NNP cord-293860-6kz0iws6 32 51 - - HYPH cord-293860-6kz0iws6 32 52 Cov2 Cov2 NNP cord-293860-6kz0iws6 32 53 infection infection NN cord-293860-6kz0iws6 32 54 . . . cord-293860-6kz0iws6 33 1 Furthermore furthermore RB cord-293860-6kz0iws6 33 2 , , , cord-293860-6kz0iws6 33 3 patients patient NNS cord-293860-6kz0iws6 33 4 from from IN cord-293860-6kz0iws6 33 5 a a DT cord-293860-6kz0iws6 33 6 BAME BAME NNP cord-293860-6kz0iws6 33 7 background background NN cord-293860-6kz0iws6 33 8 appear appear VBP cord-293860-6kz0iws6 33 9 to to TO cord-293860-6kz0iws6 33 10 have have VB cord-293860-6kz0iws6 33 11 increased increase VBN cord-293860-6kz0iws6 33 12 mortality mortality NN cord-293860-6kz0iws6 33 13 after after IN cord-293860-6kz0iws6 33 14 SARS SARS NNP cord-293860-6kz0iws6 33 15 - - HYPH cord-293860-6kz0iws6 33 16 CoV2 CoV2 NNP cord-293860-6kz0iws6 33 17 infection infection NN cord-293860-6kz0iws6 33 18 5 5 CD cord-293860-6kz0iws6 33 19 , , , cord-293860-6kz0iws6 33 20 an an DT cord-293860-6kz0iws6 33 21 observation observation NN cord-293860-6kz0iws6 33 22 that that WDT cord-293860-6kz0iws6 33 23 has have VBZ cord-293860-6kz0iws6 33 24 at at IN cord-293860-6kz0iws6 33 25 least least JJS cord-293860-6kz0iws6 33 26 partly partly RB cord-293860-6kz0iws6 33 27 ben ben NNP cord-293860-6kz0iws6 33 28 explained explain VBD cord-293860-6kz0iws6 33 29 by by IN cord-293860-6kz0iws6 33 30 the the DT cord-293860-6kz0iws6 33 31 higher high JJR cord-293860-6kz0iws6 33 32 prevalence prevalence NN cord-293860-6kz0iws6 33 33 of of IN cord-293860-6kz0iws6 33 34 central central JJ cord-293860-6kz0iws6 33 35 obesity obesity NN cord-293860-6kz0iws6 33 36 and and CC cord-293860-6kz0iws6 33 37 its -PRON- PRP$ cord-293860-6kz0iws6 33 38 metabolic metabolic JJ cord-293860-6kz0iws6 33 39 complications complication NNS cord-293860-6kz0iws6 33 40 in in IN cord-293860-6kz0iws6 33 41 this this DT cord-293860-6kz0iws6 33 42 group group NN cord-293860-6kz0iws6 33 43 6,7 6,7 CD cord-293860-6kz0iws6 33 44 . . . cord-293860-6kz0iws6 34 1 In in IN cord-293860-6kz0iws6 34 2 the the DT cord-293860-6kz0iws6 34 3 absence absence NN cord-293860-6kz0iws6 34 4 of of IN cord-293860-6kz0iws6 34 5 an an DT cord-293860-6kz0iws6 34 6 effective effective JJ cord-293860-6kz0iws6 34 7 vaccine vaccine NN cord-293860-6kz0iws6 34 8 , , , cord-293860-6kz0iws6 34 9 exploring explore VBG cord-293860-6kz0iws6 34 10 the the DT cord-293860-6kz0iws6 34 11 therapeutic therapeutic JJ cord-293860-6kz0iws6 34 12 potential potential NN cord-293860-6kz0iws6 34 13 of of IN cord-293860-6kz0iws6 34 14 immunemodulating immunemodulate VBG cord-293860-6kz0iws6 34 15 drugs drug NNS cord-293860-6kz0iws6 34 16 is be VBZ cord-293860-6kz0iws6 34 17 a a DT cord-293860-6kz0iws6 34 18 priority priority NN cord-293860-6kz0iws6 34 19 , , , cord-293860-6kz0iws6 34 20 but but CC cord-293860-6kz0iws6 34 21 the the DT cord-293860-6kz0iws6 34 22 development development NN cord-293860-6kz0iws6 34 23 of of IN cord-293860-6kz0iws6 34 24 new new JJ cord-293860-6kz0iws6 34 25 drugs drug NNS cord-293860-6kz0iws6 34 26 is be VBZ cord-293860-6kz0iws6 34 27 expensive expensive JJ cord-293860-6kz0iws6 34 28 and and CC cord-293860-6kz0iws6 34 29 time time NN cord-293860-6kz0iws6 34 30 - - HYPH cord-293860-6kz0iws6 34 31 consuming consume VBG cord-293860-6kz0iws6 34 32 . . . cord-293860-6kz0iws6 35 1 A a DT cord-293860-6kz0iws6 35 2 more more RBR cord-293860-6kz0iws6 35 3 pragmatic pragmatic JJ cord-293860-6kz0iws6 35 4 solution solution NN cord-293860-6kz0iws6 35 5 would would MD cord-293860-6kz0iws6 35 6 be be VB cord-293860-6kz0iws6 35 7 to to TO cord-293860-6kz0iws6 35 8 seek seek VB cord-293860-6kz0iws6 35 9 to to TO cord-293860-6kz0iws6 35 10 repurpose repurpose VB cord-293860-6kz0iws6 35 11 existing existing JJ cord-293860-6kz0iws6 35 12 drugs drug NNS cord-293860-6kz0iws6 35 13 , , , cord-293860-6kz0iws6 35 14 particularly particularly RB cord-293860-6kz0iws6 35 15 those those DT cord-293860-6kz0iws6 35 16 that that WDT cord-293860-6kz0iws6 35 17 might may MD cord-293860-6kz0iws6 35 18 suppress suppress VB cord-293860-6kz0iws6 35 19 the the DT cord-293860-6kz0iws6 35 20 heightened heighten VBN cord-293860-6kz0iws6 35 21 cytokine cytokine NN cord-293860-6kz0iws6 35 22 activity activity NN cord-293860-6kz0iws6 35 23 seen see VBN cord-293860-6kz0iws6 35 24 in in IN cord-293860-6kz0iws6 35 25 obesity obesity NN cord-293860-6kz0iws6 35 26 , , , cord-293860-6kz0iws6 35 27 the the DT cord-293860-6kz0iws6 35 28 major major JJ cord-293860-6kz0iws6 35 29 risk risk NN cord-293860-6kz0iws6 35 30 factor factor NN cord-293860-6kz0iws6 35 31 for for IN cord-293860-6kz0iws6 35 32 a a DT cord-293860-6kz0iws6 35 33 poor poor JJ cord-293860-6kz0iws6 35 34 prognosis prognosis NN cord-293860-6kz0iws6 35 35 in in IN cord-293860-6kz0iws6 35 36 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 35 37 . . . cord-293860-6kz0iws6 36 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 36 2 is be VBZ cord-293860-6kz0iws6 36 3 a a DT cord-293860-6kz0iws6 36 4 cysteinyl cysteinyl NNP cord-293860-6kz0iws6 36 5 leukotriene leukotriene NN cord-293860-6kz0iws6 36 6 receptor receptor NN cord-293860-6kz0iws6 36 7 antagonist antagonist NN cord-293860-6kz0iws6 36 8 licensed license VBN cord-293860-6kz0iws6 36 9 to to TO cord-293860-6kz0iws6 36 10 treat treat VB cord-293860-6kz0iws6 36 11 asthma asthma NN cord-293860-6kz0iws6 36 12 and and CC cord-293860-6kz0iws6 36 13 allergic allergic JJ cord-293860-6kz0iws6 36 14 rhinitis rhinitis NN cord-293860-6kz0iws6 36 15 . . . cord-293860-6kz0iws6 37 1 It -PRON- PRP cord-293860-6kz0iws6 37 2 has have VBZ cord-293860-6kz0iws6 37 3 been be VBN cord-293860-6kz0iws6 37 4 shown show VBN cord-293860-6kz0iws6 37 5 to to TO cord-293860-6kz0iws6 37 6 diminish diminish VB cord-293860-6kz0iws6 37 7 pulmonary pulmonary JJ cord-293860-6kz0iws6 37 8 response response NN cord-293860-6kz0iws6 37 9 to to IN cord-293860-6kz0iws6 37 10 antigen antigen NN cord-293860-6kz0iws6 37 11 , , , cord-293860-6kz0iws6 37 12 tissue tissue NN cord-293860-6kz0iws6 37 13 eosinophilia eosinophilia NN cord-293860-6kz0iws6 37 14 and and CC cord-293860-6kz0iws6 37 15 IL-5 IL-5 NNP cord-293860-6kz0iws6 37 16 expression expression NN cord-293860-6kz0iws6 37 17 in in IN cord-293860-6kz0iws6 37 18 inflammatory inflammatory JJ cord-293860-6kz0iws6 37 19 cells cell NNS cord-293860-6kz0iws6 37 20 8 8 CD cord-293860-6kz0iws6 37 21 . . . cord-293860-6kz0iws6 38 1 It -PRON- PRP cord-293860-6kz0iws6 38 2 has have VBZ cord-293860-6kz0iws6 38 3 also also RB cord-293860-6kz0iws6 38 4 been be VBN cord-293860-6kz0iws6 38 5 shown show VBN cord-293860-6kz0iws6 38 6 to to TO cord-293860-6kz0iws6 38 7 decrease decrease VB cord-293860-6kz0iws6 38 8 elevated elevated JJ cord-293860-6kz0iws6 38 9 levels level NNS cord-293860-6kz0iws6 38 10 of of IN cord-293860-6kz0iws6 38 11 IL-1 IL-1 NNP cord-293860-6kz0iws6 38 12 and and CC cord-293860-6kz0iws6 38 13 IL8 il8 VB cord-293860-6kz0iws6 38 14 in in IN cord-293860-6kz0iws6 38 15 humans human NNS cord-293860-6kz0iws6 38 16 with with IN cord-293860-6kz0iws6 38 17 viral viral JJ cord-293860-6kz0iws6 38 18 upper upper JJ cord-293860-6kz0iws6 38 19 respiratory respiratory JJ cord-293860-6kz0iws6 38 20 tract tract NN cord-293860-6kz0iws6 38 21 infections infection NNS cord-293860-6kz0iws6 38 22 compared compare VBN cord-293860-6kz0iws6 38 23 with with IN cord-293860-6kz0iws6 38 24 placebo placebo NN cord-293860-6kz0iws6 38 25 - - HYPH cord-293860-6kz0iws6 38 26 treated treat VBN cord-293860-6kz0iws6 38 27 patients patient NNS cord-293860-6kz0iws6 38 28 9 9 CD cord-293860-6kz0iws6 38 29 . . . cord-293860-6kz0iws6 39 1 In in IN cord-293860-6kz0iws6 39 2 addition addition NN cord-293860-6kz0iws6 39 3 , , , cord-293860-6kz0iws6 39 4 in in IN cord-293860-6kz0iws6 39 5 silico silico NN cord-293860-6kz0iws6 39 6 computer computer NN cord-293860-6kz0iws6 39 7 modelling modelling NN cord-293860-6kz0iws6 39 8 studies study NNS cord-293860-6kz0iws6 39 9 have have VBP cord-293860-6kz0iws6 39 10 demonstrated demonstrate VBN cord-293860-6kz0iws6 39 11 a a DT cord-293860-6kz0iws6 39 12 high high JJ cord-293860-6kz0iws6 39 13 binding bind VBG cord-293860-6kz0iws6 39 14 affinity affinity NN cord-293860-6kz0iws6 39 15 of of IN cord-293860-6kz0iws6 39 16 the the DT cord-293860-6kz0iws6 39 17 montelukast montelukast NN cord-293860-6kz0iws6 39 18 molecule molecule NN cord-293860-6kz0iws6 39 19 to to IN cord-293860-6kz0iws6 39 20 the the DT cord-293860-6kz0iws6 39 21 SARS SARS NNP cord-293860-6kz0iws6 39 22 - - HYPH cord-293860-6kz0iws6 39 23 CoV2 CoV2 NNP cord-293860-6kz0iws6 39 24 virus virus NN cord-293860-6kz0iws6 39 25 's 's POS cord-293860-6kz0iws6 39 26 main main JJ cord-293860-6kz0iws6 39 27 protease protease NN cord-293860-6kz0iws6 39 28 enzyme enzyme NN cord-293860-6kz0iws6 39 29 substrate substrate NN cord-293860-6kz0iws6 39 30 - - HYPH cord-293860-6kz0iws6 39 31 binding bind VBG cord-293860-6kz0iws6 39 32 pocket pocket NN cord-293860-6kz0iws6 39 33 that that WDT cord-293860-6kz0iws6 39 34 is be VBZ cord-293860-6kz0iws6 39 35 involved involve VBN cord-293860-6kz0iws6 39 36 in in IN cord-293860-6kz0iws6 39 37 virus virus NN cord-293860-6kz0iws6 39 38 RNA RNA NNP cord-293860-6kz0iws6 39 39 synthesis synthesis NN cord-293860-6kz0iws6 39 40 and and CC cord-293860-6kz0iws6 39 41 replication replication NN cord-293860-6kz0iws6 39 42 10 10 CD cord-293860-6kz0iws6 39 43 , , , cord-293860-6kz0iws6 39 44 11 11 CD cord-293860-6kz0iws6 39 45 . . . cord-293860-6kz0iws6 40 1 Evidence evidence NN cord-293860-6kz0iws6 40 2 supporting support VBG cord-293860-6kz0iws6 40 3 montelukast montelukast NNP cord-293860-6kz0iws6 40 4 as as IN cord-293860-6kz0iws6 40 5 a a DT cord-293860-6kz0iws6 40 6 candidate candidate NN cord-293860-6kz0iws6 40 7 COVID-19 covid-19 CD cord-293860-6kz0iws6 40 8 therapy therapy NN cord-293860-6kz0iws6 40 9 in in IN cord-293860-6kz0iws6 40 10 individuals individual NNS cord-293860-6kz0iws6 40 11 with with IN cord-293860-6kz0iws6 40 12 obesity obesity NN cord-293860-6kz0iws6 40 13 : : : cord-293860-6kz0iws6 40 14 Patients patient NNS cord-293860-6kz0iws6 40 15 affected affect VBN cord-293860-6kz0iws6 40 16 by by IN cord-293860-6kz0iws6 40 17 severe severe JJ cord-293860-6kz0iws6 40 18 obesity obesity NN cord-293860-6kz0iws6 40 19 share share VBP cord-293860-6kz0iws6 40 20 a a DT cord-293860-6kz0iws6 40 21 common common JJ cord-293860-6kz0iws6 40 22 physiological physiological JJ cord-293860-6kz0iws6 40 23 response response NN cord-293860-6kz0iws6 40 24 with with IN cord-293860-6kz0iws6 40 25 patients patient NNS cord-293860-6kz0iws6 40 26 with with IN cord-293860-6kz0iws6 40 27 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 40 28 as as IN cord-293860-6kz0iws6 40 29 both both DT cord-293860-6kz0iws6 40 30 have have VBP cord-293860-6kz0iws6 40 31 raised raise VBN cord-293860-6kz0iws6 40 32 concentrations concentration NNS cord-293860-6kz0iws6 40 33 of of IN cord-293860-6kz0iws6 40 34 pro pro JJ cord-293860-6kz0iws6 40 35 - - JJ cord-293860-6kz0iws6 40 36 inflammatory inflammatory JJ cord-293860-6kz0iws6 40 37 cytokines cytokine NNS cord-293860-6kz0iws6 40 38 ( ( -LRB- cord-293860-6kz0iws6 40 39 e.g. e.g. RB cord-293860-6kz0iws6 40 40 , , , cord-293860-6kz0iws6 40 41 TNF TNF NNP cord-293860-6kz0iws6 40 42 - - HYPH cord-293860-6kz0iws6 40 43 a a NNP cord-293860-6kz0iws6 40 44 , , , cord-293860-6kz0iws6 40 45 IL1 IL1 NNP cord-293860-6kz0iws6 40 46 and and CC cord-293860-6kz0iws6 40 47 IL6 IL6 NNP cord-293860-6kz0iws6 40 48 ) ) -RRB- cord-293860-6kz0iws6 40 49 and and CC cord-293860-6kz0iws6 40 50 T T NNP cord-293860-6kz0iws6 40 51 - - HYPH cord-293860-6kz0iws6 40 52 helper-2 helper-2 NNP cord-293860-6kz0iws6 40 53 cytokines cytokine NNS cord-293860-6kz0iws6 40 54 ( ( -LRB- cord-293860-6kz0iws6 40 55 IL4 il4 NN cord-293860-6kz0iws6 40 56 , , , cord-293860-6kz0iws6 40 57 IL10 IL10 NNP cord-293860-6kz0iws6 40 58 ) ) -RRB- cord-293860-6kz0iws6 41 1 [ [ -LRB- cord-293860-6kz0iws6 41 2 12 12 CD cord-293860-6kz0iws6 41 3 ] ] -RRB- cord-293860-6kz0iws6 41 4 [ [ -LRB- cord-293860-6kz0iws6 41 5 13 13 CD cord-293860-6kz0iws6 41 6 ] ] -RRB- cord-293860-6kz0iws6 42 1 [ [ -LRB- cord-293860-6kz0iws6 42 2 14 14 CD cord-293860-6kz0iws6 42 3 ] ] -RRB- cord-293860-6kz0iws6 42 4 . . . cord-293860-6kz0iws6 43 1 Whilst whilst IN cord-293860-6kz0iws6 43 2 it -PRON- PRP cord-293860-6kz0iws6 43 3 is be VBZ cord-293860-6kz0iws6 43 4 impossible impossible JJ cord-293860-6kz0iws6 43 5 to to TO cord-293860-6kz0iws6 43 6 exclude exclude VB cord-293860-6kz0iws6 43 7 increased increase VBN cord-293860-6kz0iws6 43 8 viral viral JJ cord-293860-6kz0iws6 43 9 burden burden NN cord-293860-6kz0iws6 43 10 as as IN cord-293860-6kz0iws6 43 11 the the DT cord-293860-6kz0iws6 43 12 driver driver NN cord-293860-6kz0iws6 43 13 for for IN cord-293860-6kz0iws6 43 14 this this DT cord-293860-6kz0iws6 43 15 inflammatory inflammatory JJ cord-293860-6kz0iws6 43 16 response response NN cord-293860-6kz0iws6 43 17 in in IN cord-293860-6kz0iws6 43 18 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 43 19 , , , cord-293860-6kz0iws6 43 20 there there EX cord-293860-6kz0iws6 43 21 is be VBZ cord-293860-6kz0iws6 43 22 evidence evidence NN cord-293860-6kz0iws6 43 23 that that IN cord-293860-6kz0iws6 43 24 some some DT cord-293860-6kz0iws6 43 25 patients patient NNS cord-293860-6kz0iws6 43 26 develop develop VBP cord-293860-6kz0iws6 43 27 ' ' `` cord-293860-6kz0iws6 43 28 cytokine cytokine NN cord-293860-6kz0iws6 43 29 storm storm NN cord-293860-6kz0iws6 43 30 ( ( -LRB- cord-293860-6kz0iws6 43 31 release release NN cord-293860-6kz0iws6 43 32 ) ) -RRB- cord-293860-6kz0iws6 43 33 syndrome syndrome NN cord-293860-6kz0iws6 43 34 ' ' '' cord-293860-6kz0iws6 43 35 , , , cord-293860-6kz0iws6 43 36 described describe VBD cord-293860-6kz0iws6 43 37 as as IN cord-293860-6kz0iws6 43 38 an an DT cord-293860-6kz0iws6 43 39 uncontrolled uncontrolled JJ cord-293860-6kz0iws6 43 40 and and CC cord-293860-6kz0iws6 43 41 overwhelming overwhelming JJ cord-293860-6kz0iws6 43 42 release release NN cord-293860-6kz0iws6 43 43 of of IN cord-293860-6kz0iws6 43 44 proinflammatory proinflammatory JJ cord-293860-6kz0iws6 43 45 mediators mediator NNS cord-293860-6kz0iws6 43 46 by by IN cord-293860-6kz0iws6 43 47 an an DT cord-293860-6kz0iws6 43 48 overly overly RB cord-293860-6kz0iws6 43 49 - - HYPH cord-293860-6kz0iws6 43 50 activated activate VBN cord-293860-6kz0iws6 43 51 immune immune JJ cord-293860-6kz0iws6 43 52 system system NN cord-293860-6kz0iws6 43 53 12 12 CD cord-293860-6kz0iws6 43 54 , , , cord-293860-6kz0iws6 43 55 13 13 CD cord-293860-6kz0iws6 43 56 , , , cord-293860-6kz0iws6 43 57 15 15 CD cord-293860-6kz0iws6 43 58 . . . cord-293860-6kz0iws6 44 1 An an DT cord-293860-6kz0iws6 44 2 overwhelming overwhelming JJ cord-293860-6kz0iws6 44 3 production production NN cord-293860-6kz0iws6 44 4 of of IN cord-293860-6kz0iws6 44 5 proinflammatory proinflammatory JJ cord-293860-6kz0iws6 44 6 mediators mediator NNS cord-293860-6kz0iws6 44 7 in in IN cord-293860-6kz0iws6 44 8 the the DT cord-293860-6kz0iws6 44 9 lungs lung NNS cord-293860-6kz0iws6 44 10 causes cause VBZ cord-293860-6kz0iws6 44 11 localised localise VBN cord-293860-6kz0iws6 44 12 pulmonary pulmonary JJ cord-293860-6kz0iws6 44 13 injury injury NN cord-293860-6kz0iws6 44 14 characterised characterise VBN cord-293860-6kz0iws6 44 15 by by IN cord-293860-6kz0iws6 44 16 diffuse diffuse JJ cord-293860-6kz0iws6 44 17 alveolar alveolar JJ cord-293860-6kz0iws6 44 18 damage damage NN cord-293860-6kz0iws6 44 19 with with IN cord-293860-6kz0iws6 44 20 epithelial epithelial JJ cord-293860-6kz0iws6 44 21 and and CC cord-293860-6kz0iws6 44 22 endothelial endothelial JJ cord-293860-6kz0iws6 44 23 apoptosis apoptosis NN cord-293860-6kz0iws6 44 24 , , , cord-293860-6kz0iws6 44 25 and and CC cord-293860-6kz0iws6 44 26 thrombosis thrombosis NN cord-293860-6kz0iws6 44 27 due due IN cord-293860-6kz0iws6 44 28 to to IN cord-293860-6kz0iws6 44 29 dysregulated dysregulated JJ cord-293860-6kz0iws6 44 30 coagulation coagulation NN cord-293860-6kz0iws6 44 31 and and CC cord-293860-6kz0iws6 44 32 fibrinolysis fibrinolysis NN cord-293860-6kz0iws6 44 33 . . . cord-293860-6kz0iws6 45 1 These these DT cord-293860-6kz0iws6 45 2 mediators mediator NNS cord-293860-6kz0iws6 45 3 may may MD cord-293860-6kz0iws6 45 4 also also RB cord-293860-6kz0iws6 45 5 leak leak VB cord-293860-6kz0iws6 45 6 into into IN cord-293860-6kz0iws6 45 7 systemic systemic JJ cord-293860-6kz0iws6 45 8 circulation circulation NN cord-293860-6kz0iws6 45 9 leading lead VBG cord-293860-6kz0iws6 45 10 to to IN cord-293860-6kz0iws6 45 11 cardiac cardiac JJ cord-293860-6kz0iws6 45 12 , , , cord-293860-6kz0iws6 45 13 renal renal JJ cord-293860-6kz0iws6 45 14 and and CC cord-293860-6kz0iws6 45 15 hepatic hepatic JJ cord-293860-6kz0iws6 45 16 inflammation inflammation NN cord-293860-6kz0iws6 45 17 and and CC cord-293860-6kz0iws6 45 18 multiorgan multiorgan NN cord-293860-6kz0iws6 45 19 failure failure NN cord-293860-6kz0iws6 45 20 16 16 CD cord-293860-6kz0iws6 45 21 . . . cord-293860-6kz0iws6 46 1 The the DT cord-293860-6kz0iws6 46 2 background background NN cord-293860-6kz0iws6 46 3 chronic chronic JJ cord-293860-6kz0iws6 46 4 inflammatory inflammatory JJ cord-293860-6kz0iws6 46 5 state state NN cord-293860-6kz0iws6 46 6 associated associate VBN cord-293860-6kz0iws6 46 7 with with IN cord-293860-6kz0iws6 46 8 obesity obesity NN cord-293860-6kz0iws6 46 9 could could MD cord-293860-6kz0iws6 46 10 act act VB cord-293860-6kz0iws6 46 11 as as IN cord-293860-6kz0iws6 46 12 a a DT cord-293860-6kz0iws6 46 13 catalyst catalyst NN cord-293860-6kz0iws6 46 14 for for IN cord-293860-6kz0iws6 46 15 the the DT cord-293860-6kz0iws6 46 16 a a DT cord-293860-6kz0iws6 46 17 massive massive JJ cord-293860-6kz0iws6 46 18 inflammatory inflammatory JJ cord-293860-6kz0iws6 46 19 response response NN cord-293860-6kz0iws6 46 20 to to IN cord-293860-6kz0iws6 46 21 SARS SARS NNP cord-293860-6kz0iws6 46 22 - - HYPH cord-293860-6kz0iws6 46 23 CoV2 CoV2 NNS cord-293860-6kz0iws6 46 24 by by IN cord-293860-6kz0iws6 46 25 priming prime VBG cord-293860-6kz0iws6 46 26 the the DT cord-293860-6kz0iws6 46 27 immune immune JJ cord-293860-6kz0iws6 46 28 system system NN cord-293860-6kz0iws6 46 29 , , , cord-293860-6kz0iws6 46 30 triggered trigger VBN cord-293860-6kz0iws6 46 31 by by IN cord-293860-6kz0iws6 46 32 the the DT cord-293860-6kz0iws6 46 33 ' ' `` cord-293860-6kz0iws6 46 34 second second JJ cord-293860-6kz0iws6 46 35 hit hit NN cord-293860-6kz0iws6 46 36 ' ' '' cord-293860-6kz0iws6 46 37 of of IN cord-293860-6kz0iws6 46 38 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 46 39 , , , cord-293860-6kz0iws6 46 40 and and CC cord-293860-6kz0iws6 46 41 explaining explain VBG cord-293860-6kz0iws6 46 42 why why WRB cord-293860-6kz0iws6 46 43 those those DT cord-293860-6kz0iws6 46 44 with with IN cord-293860-6kz0iws6 46 45 obesity obesity NN cord-293860-6kz0iws6 46 46 are be VBP cord-293860-6kz0iws6 46 47 more more RBR cord-293860-6kz0iws6 46 48 likely likely JJ cord-293860-6kz0iws6 46 49 to to TO cord-293860-6kz0iws6 46 50 become become VB cord-293860-6kz0iws6 46 51 severely severely RB cord-293860-6kz0iws6 46 52 ill ill JJ cord-293860-6kz0iws6 46 53 , , , cord-293860-6kz0iws6 46 54 require require VB cord-293860-6kz0iws6 46 55 ICU ICU NNP cord-293860-6kz0iws6 46 56 care care NN cord-293860-6kz0iws6 46 57 and and CC cord-293860-6kz0iws6 46 58 die die VBP cord-293860-6kz0iws6 46 59 . . . cord-293860-6kz0iws6 47 1 Severe severe JJ cord-293860-6kz0iws6 47 2 lymphopenia lymphopenia NNP cord-293860-6kz0iws6 47 3 with with IN cord-293860-6kz0iws6 47 4 hyperactivated hyperactivated JJ cord-293860-6kz0iws6 47 5 proinflammatory proinflammatory NNP cord-293860-6kz0iws6 47 6 T T NNP cord-293860-6kz0iws6 47 7 cells cell NNS cord-293860-6kz0iws6 47 8 and and CC cord-293860-6kz0iws6 47 9 decreased decrease VBD cord-293860-6kz0iws6 48 1 regulatory regulatory JJ cord-293860-6kz0iws6 48 2 T T NNP cord-293860-6kz0iws6 48 3 cells cell NNS cord-293860-6kz0iws6 48 4 are be VBP cord-293860-6kz0iws6 48 5 commonly commonly RB cord-293860-6kz0iws6 48 6 seen see VBN cord-293860-6kz0iws6 48 7 in in IN cord-293860-6kz0iws6 48 8 critically critically RB cord-293860-6kz0iws6 48 9 ill ill JJ cord-293860-6kz0iws6 49 1 COVID-19 covid-19 JJ cord-293860-6kz0iws6 49 2 patients patient NNS cord-293860-6kz0iws6 49 3 supporting support VBG cord-293860-6kz0iws6 49 4 the the DT cord-293860-6kz0iws6 49 5 likelihood likelihood NN cord-293860-6kz0iws6 49 6 of of IN cord-293860-6kz0iws6 49 7 a a DT cord-293860-6kz0iws6 49 8 dysregulated dysregulate VBN cord-293860-6kz0iws6 49 9 immune immune JJ cord-293860-6kz0iws6 49 10 response response NN cord-293860-6kz0iws6 49 11 to to IN cord-293860-6kz0iws6 49 12 the the DT cord-293860-6kz0iws6 49 13 viral viral JJ cord-293860-6kz0iws6 49 14 infection infection NN cord-293860-6kz0iws6 49 15 12 12 CD cord-293860-6kz0iws6 49 16 . . . cord-293860-6kz0iws6 50 1 Leukotrienes leukotriene NNS cord-293860-6kz0iws6 50 2 ( ( -LRB- cord-293860-6kz0iws6 50 3 LTC4 LTC4 NNP cord-293860-6kz0iws6 50 4 , , , cord-293860-6kz0iws6 50 5 LTD4 LTD4 NNP cord-293860-6kz0iws6 50 6 , , , cord-293860-6kz0iws6 50 7 and and CC cord-293860-6kz0iws6 50 8 LTE4 LTE4 NNP cord-293860-6kz0iws6 50 9 ) ) -RRB- cord-293860-6kz0iws6 50 10 are be VBP cord-293860-6kz0iws6 50 11 peptide peptide NN cord-293860-6kz0iws6 50 12 - - HYPH cord-293860-6kz0iws6 50 13 conjugated conjugate VBN cord-293860-6kz0iws6 50 14 lipids lipid NNS cord-293860-6kz0iws6 50 15 that that WDT cord-293860-6kz0iws6 50 16 are be VBP cord-293860-6kz0iws6 50 17 prominent prominent JJ cord-293860-6kz0iws6 50 18 products product NNS cord-293860-6kz0iws6 50 19 of of IN cord-293860-6kz0iws6 50 20 activated activate VBN cord-293860-6kz0iws6 50 21 eosinophils eosinophil NNS cord-293860-6kz0iws6 50 22 , , , cord-293860-6kz0iws6 50 23 basophils basophil NNS cord-293860-6kz0iws6 50 24 , , , cord-293860-6kz0iws6 50 25 mast mast NN cord-293860-6kz0iws6 50 26 cells cell NNS cord-293860-6kz0iws6 50 27 and and CC cord-293860-6kz0iws6 50 28 macrophages macrophage NNS cord-293860-6kz0iws6 50 29 17 17 CD cord-293860-6kz0iws6 50 30 , , , cord-293860-6kz0iws6 50 31 18 18 CD cord-293860-6kz0iws6 50 32 . . . cord-293860-6kz0iws6 51 1 They -PRON- PRP cord-293860-6kz0iws6 51 2 are be VBP cord-293860-6kz0iws6 51 3 generated generate VBN cord-293860-6kz0iws6 51 4 de de IN cord-293860-6kz0iws6 51 5 novo novo NNP cord-293860-6kz0iws6 51 6 from from IN cord-293860-6kz0iws6 51 7 cell cell NN cord-293860-6kz0iws6 51 8 membrane membrane NN cord-293860-6kz0iws6 51 9 phospholipid phospholipid NN cord-293860-6kz0iws6 51 10 - - HYPH cord-293860-6kz0iws6 51 11 associated associate VBN cord-293860-6kz0iws6 51 12 arachidonic arachidonic NN cord-293860-6kz0iws6 51 13 acid acid NN cord-293860-6kz0iws6 51 14 via via IN cord-293860-6kz0iws6 51 15 the the DT cord-293860-6kz0iws6 51 16 5-lipoxygenase 5-lipoxygenase CD cord-293860-6kz0iws6 51 17 pathway pathway NN cord-293860-6kz0iws6 51 18 . . . cord-293860-6kz0iws6 52 1 Known know VBN cord-293860-6kz0iws6 52 2 to to TO cord-293860-6kz0iws6 52 3 cause cause VB cord-293860-6kz0iws6 52 4 contraction contraction NN cord-293860-6kz0iws6 52 5 of of IN cord-293860-6kz0iws6 52 6 bronchial bronchial JJ cord-293860-6kz0iws6 52 7 smooth smooth JJ cord-293860-6kz0iws6 52 8 muscle muscle NN cord-293860-6kz0iws6 52 9 , , , cord-293860-6kz0iws6 52 10 leukotrienes leukotriene NNS cord-293860-6kz0iws6 52 11 are be VBP cord-293860-6kz0iws6 52 12 now now RB cord-293860-6kz0iws6 52 13 also also RB cord-293860-6kz0iws6 52 14 recognised recognise VBN cord-293860-6kz0iws6 52 15 as as RB cord-293860-6kz0iws6 52 16 potent potent JJ cord-293860-6kz0iws6 52 17 inflammatory inflammatory JJ cord-293860-6kz0iws6 52 18 mediators mediator NNS cord-293860-6kz0iws6 52 19 that that WDT cord-293860-6kz0iws6 52 20 initiate initiate VBP cord-293860-6kz0iws6 52 21 and and CC cord-293860-6kz0iws6 52 22 propagate propagate VBP cord-293860-6kz0iws6 52 23 a a DT cord-293860-6kz0iws6 52 24 diverse diverse JJ cord-293860-6kz0iws6 52 25 array array NN cord-293860-6kz0iws6 52 26 of of IN cord-293860-6kz0iws6 52 27 biologic biologic JJ cord-293860-6kz0iws6 52 28 responses response NNS cord-293860-6kz0iws6 52 29 including include VBG cord-293860-6kz0iws6 52 30 macrophage macrophage NN cord-293860-6kz0iws6 52 31 activation activation NN cord-293860-6kz0iws6 52 32 , , , cord-293860-6kz0iws6 52 33 mast mast JJ cord-293860-6kz0iws6 52 34 cell cell NN cord-293860-6kz0iws6 52 35 cytokine cytokine NN cord-293860-6kz0iws6 52 36 secretion secretion NN cord-293860-6kz0iws6 52 37 and and CC cord-293860-6kz0iws6 52 38 dendritic dendritic JJ cord-293860-6kz0iws6 52 39 cell cell NN cord-293860-6kz0iws6 52 40 maturation maturation NN cord-293860-6kz0iws6 52 41 and and CC cord-293860-6kz0iws6 52 42 migration migration NN cord-293860-6kz0iws6 52 43 17 17 CD cord-293860-6kz0iws6 52 44 , , , cord-293860-6kz0iws6 52 45 18 18 CD cord-293860-6kz0iws6 52 46 . . . cord-293860-6kz0iws6 53 1 Animal animal NN cord-293860-6kz0iws6 53 2 studies study NNS cord-293860-6kz0iws6 53 3 indicate indicate VBP cord-293860-6kz0iws6 53 4 a a DT cord-293860-6kz0iws6 53 5 significant significant JJ cord-293860-6kz0iws6 53 6 role role NN cord-293860-6kz0iws6 53 7 for for IN cord-293860-6kz0iws6 53 8 leukotrienes leukotriene NNS cord-293860-6kz0iws6 53 9 in in IN cord-293860-6kz0iws6 53 10 adaptive adaptive JJ cord-293860-6kz0iws6 53 11 immunity immunity NN cord-293860-6kz0iws6 53 12 , , , cord-293860-6kz0iws6 53 13 particularly particularly RB cord-293860-6kz0iws6 53 14 the the DT cord-293860-6kz0iws6 53 15 induction induction NN cord-293860-6kz0iws6 53 16 of of IN cord-293860-6kz0iws6 53 17 Th2 th2 CD cord-293860-6kz0iws6 53 18 response response NN cord-293860-6kz0iws6 53 19 in in IN cord-293860-6kz0iws6 53 20 the the DT cord-293860-6kz0iws6 53 21 lung lung NN cord-293860-6kz0iws6 53 22 via via IN cord-293860-6kz0iws6 53 23 their -PRON- PRP$ cord-293860-6kz0iws6 53 24 effect effect NN cord-293860-6kz0iws6 53 25 on on IN cord-293860-6kz0iws6 53 26 dendritic dendritic JJ cord-293860-6kz0iws6 53 27 cells cell NNS cord-293860-6kz0iws6 53 28 and and CC cord-293860-6kz0iws6 53 29 cytokine cytokine NN cord-293860-6kz0iws6 53 30 generation generation NN cord-293860-6kz0iws6 53 31 ( ( -LRB- cord-293860-6kz0iws6 53 32 mainly mainly RB cord-293860-6kz0iws6 53 33 IL4 il4 JJ cord-293860-6kz0iws6 53 34 ) ) -RRB- cord-293860-6kz0iws6 53 35 , , , cord-293860-6kz0iws6 53 36 the the DT cord-293860-6kz0iws6 53 37 recruitment recruitment NN cord-293860-6kz0iws6 53 38 and/or and/or CC cord-293860-6kz0iws6 53 39 activation activation NN cord-293860-6kz0iws6 53 40 of of IN cord-293860-6kz0iws6 53 41 effector effector NN cord-293860-6kz0iws6 53 42 cells cell NNS cord-293860-6kz0iws6 53 43 ( ( -LRB- cord-293860-6kz0iws6 53 44 especially especially RB cord-293860-6kz0iws6 53 45 eosinophils eosinophils NN cord-293860-6kz0iws6 53 46 and and CC cord-293860-6kz0iws6 53 47 mast mast NN cord-293860-6kz0iws6 53 48 cells cell NNS cord-293860-6kz0iws6 53 49 ) ) -RRB- cord-293860-6kz0iws6 53 50 , , , cord-293860-6kz0iws6 53 51 pulmonary pulmonary JJ cord-293860-6kz0iws6 53 52 inflammation inflammation NN cord-293860-6kz0iws6 53 53 , , , cord-293860-6kz0iws6 53 54 microvascular microvascular JJ cord-293860-6kz0iws6 53 55 permeability permeability NN cord-293860-6kz0iws6 53 56 and and CC cord-293860-6kz0iws6 53 57 pulmonary pulmonary JJ cord-293860-6kz0iws6 53 58 fibrosis fibrosis NN cord-293860-6kz0iws6 53 59 17 17 CD cord-293860-6kz0iws6 53 60 , , , cord-293860-6kz0iws6 53 61 19 19 CD cord-293860-6kz0iws6 53 62 . . . cord-293860-6kz0iws6 54 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 54 2 20,21 20,21 CD cord-293860-6kz0iws6 54 3 ( ( -LRB- cord-293860-6kz0iws6 54 4 montelukast montelukast NNP cord-293860-6kz0iws6 54 5 sodium sodium NN cord-293860-6kz0iws6 54 6 : : : cord-293860-6kz0iws6 55 1 C C NNP cord-293860-6kz0iws6 55 2 35 35 CD cord-293860-6kz0iws6 55 3 H H NNP cord-293860-6kz0iws6 55 4 36 36 CD cord-293860-6kz0iws6 55 5 ClNO clno NN cord-293860-6kz0iws6 55 6 3 3 CD cord-293860-6kz0iws6 55 7 S S NNP cord-293860-6kz0iws6 55 8 ) ) -RRB- cord-293860-6kz0iws6 55 9 is be VBZ cord-293860-6kz0iws6 55 10 a a DT cord-293860-6kz0iws6 55 11 leukotriene leukotriene NN cord-293860-6kz0iws6 55 12 receptor receptor NN cord-293860-6kz0iws6 55 13 antagonist antagonist NN cord-293860-6kz0iws6 55 14 which which WDT cord-293860-6kz0iws6 55 15 demonstrates demonstrate VBZ cord-293860-6kz0iws6 55 16 a a DT cord-293860-6kz0iws6 55 17 marked marked JJ cord-293860-6kz0iws6 55 18 affinity affinity NN cord-293860-6kz0iws6 55 19 and and CC cord-293860-6kz0iws6 55 20 selectivity selectivity NN cord-293860-6kz0iws6 55 21 to to IN cord-293860-6kz0iws6 55 22 the the DT cord-293860-6kz0iws6 55 23 cysteinyl cysteinyl NNP cord-293860-6kz0iws6 55 24 leukotriene leukotriene NN cord-293860-6kz0iws6 55 25 receptor receptor NN cord-293860-6kz0iws6 55 26 type-1 type-1 NNP cord-293860-6kz0iws6 55 27 , , , cord-293860-6kz0iws6 55 28 thus thus RB cord-293860-6kz0iws6 55 29 it -PRON- PRP cord-293860-6kz0iws6 55 30 elicits elicit VBZ cord-293860-6kz0iws6 55 31 substantial substantial JJ cord-293860-6kz0iws6 55 32 blockage blockage NN cord-293860-6kz0iws6 55 33 of of IN cord-293860-6kz0iws6 55 34 any any DT cord-293860-6kz0iws6 55 35 LTD4 LTD4 NNP cord-293860-6kz0iws6 55 36 leukotriene leukotriene NN cord-293860-6kz0iws6 55 37 - - HYPH cord-293860-6kz0iws6 55 38 mediated mediate VBN cord-293860-6kz0iws6 55 39 effect effect NN cord-293860-6kz0iws6 55 40 , , , cord-293860-6kz0iws6 55 41 resulting result VBG cord-293860-6kz0iws6 55 42 in in IN cord-293860-6kz0iws6 55 43 reduced reduce VBN cord-293860-6kz0iws6 55 44 inflammation inflammation NN cord-293860-6kz0iws6 55 45 and and CC cord-293860-6kz0iws6 55 46 relaxation relaxation NN cord-293860-6kz0iws6 55 47 of of IN cord-293860-6kz0iws6 55 48 smooth smooth JJ cord-293860-6kz0iws6 55 49 muscle muscle NN cord-293860-6kz0iws6 55 50 . . . cord-293860-6kz0iws6 56 1 It -PRON- PRP cord-293860-6kz0iws6 56 2 has have VBZ cord-293860-6kz0iws6 56 3 also also RB cord-293860-6kz0iws6 56 4 been be VBN cord-293860-6kz0iws6 56 5 shown show VBN cord-293860-6kz0iws6 56 6 to to TO cord-293860-6kz0iws6 56 7 diminish diminish VB cord-293860-6kz0iws6 56 8 the the DT cord-293860-6kz0iws6 56 9 pulmonary pulmonary JJ cord-293860-6kz0iws6 56 10 response response NN cord-293860-6kz0iws6 56 11 to to IN cord-293860-6kz0iws6 56 12 antigen antigen NN cord-293860-6kz0iws6 56 13 , , , cord-293860-6kz0iws6 56 14 tissue tissue NN cord-293860-6kz0iws6 56 15 eosinophilia eosinophilia NN cord-293860-6kz0iws6 56 16 and and CC cord-293860-6kz0iws6 56 17 the the DT cord-293860-6kz0iws6 56 18 number number NN cord-293860-6kz0iws6 56 19 of of IN cord-293860-6kz0iws6 56 20 inflammatory inflammatory JJ cord-293860-6kz0iws6 56 21 cells cell NNS cord-293860-6kz0iws6 56 22 expressing express VBG cord-293860-6kz0iws6 56 23 IL-5 IL-5 NNP cord-293860-6kz0iws6 56 24 8 8 CD cord-293860-6kz0iws6 56 25 . . . cord-293860-6kz0iws6 57 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 57 2 decreases decrease VBZ cord-293860-6kz0iws6 57 3 elevated elevated JJ cord-293860-6kz0iws6 57 4 levels level NNS cord-293860-6kz0iws6 57 5 of of IN cord-293860-6kz0iws6 57 6 IL-1 IL-1 NNP cord-293860-6kz0iws6 57 7 and and CC cord-293860-6kz0iws6 57 8 IL8 il8 VB cord-293860-6kz0iws6 57 9 in in IN cord-293860-6kz0iws6 57 10 nasal nasal NN cord-293860-6kz0iws6 57 11 washouts washout NNS cord-293860-6kz0iws6 57 12 in in IN cord-293860-6kz0iws6 57 13 humans human NNS cord-293860-6kz0iws6 57 14 with with IN cord-293860-6kz0iws6 57 15 viral viral JJ cord-293860-6kz0iws6 57 16 upper upper JJ cord-293860-6kz0iws6 57 17 respiratory respiratory JJ cord-293860-6kz0iws6 57 18 tract tract NN cord-293860-6kz0iws6 57 19 infections infection NNS cord-293860-6kz0iws6 57 20 compared compare VBN cord-293860-6kz0iws6 57 21 with with IN cord-293860-6kz0iws6 57 22 placebo placebo NN cord-293860-6kz0iws6 57 23 - - HYPH cord-293860-6kz0iws6 57 24 treated treat VBN cord-293860-6kz0iws6 57 25 patients patient NNS cord-293860-6kz0iws6 57 26 9 9 CD cord-293860-6kz0iws6 57 27 . . . cord-293860-6kz0iws6 58 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 58 2 was be VBD cord-293860-6kz0iws6 58 3 first first RB cord-293860-6kz0iws6 58 4 approved approve VBN cord-293860-6kz0iws6 58 5 for for IN cord-293860-6kz0iws6 58 6 clinical clinical JJ cord-293860-6kz0iws6 58 7 use use NN cord-293860-6kz0iws6 58 8 by by IN cord-293860-6kz0iws6 58 9 the the DT cord-293860-6kz0iws6 58 10 US US NNP cord-293860-6kz0iws6 58 11 FDA FDA NNP cord-293860-6kz0iws6 58 12 in in IN cord-293860-6kz0iws6 58 13 1998 1998 CD cord-293860-6kz0iws6 58 14 . . . cord-293860-6kz0iws6 59 1 It -PRON- PRP cord-293860-6kz0iws6 59 2 is be VBZ cord-293860-6kz0iws6 59 3 currently currently RB cord-293860-6kz0iws6 59 4 licensed license VBN cord-293860-6kz0iws6 59 5 to to TO cord-293860-6kz0iws6 59 6 treat treat VB cord-293860-6kz0iws6 59 7 asthma asthma NN cord-293860-6kz0iws6 59 8 , , , cord-293860-6kz0iws6 59 9 exercise exercise NN cord-293860-6kz0iws6 59 10 - - HYPH cord-293860-6kz0iws6 59 11 induced induce VBN cord-293860-6kz0iws6 59 12 bronchospasm bronchospasm JJ cord-293860-6kz0iws6 59 13 and and CC cord-293860-6kz0iws6 59 14 allergic allergic JJ cord-293860-6kz0iws6 59 15 rhinitis rhinitis NN cord-293860-6kz0iws6 59 16 . . . cord-293860-6kz0iws6 60 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 60 2 10 10 CD cord-293860-6kz0iws6 60 3 mg mg NNP cord-293860-6kz0iws6 60 4 is be VBZ cord-293860-6kz0iws6 60 5 given give VBN cord-293860-6kz0iws6 60 6 orally orally RB cord-293860-6kz0iws6 60 7 once once RB cord-293860-6kz0iws6 60 8 daily daily JJ cord-293860-6kz0iws6 60 9 ( ( -LRB- cord-293860-6kz0iws6 60 10 oral oral JJ cord-293860-6kz0iws6 60 11 bioavailability bioavailability NN cord-293860-6kz0iws6 60 12 64 64 CD cord-293860-6kz0iws6 60 13 % % NN cord-293860-6kz0iws6 60 14 ) ) -RRB- cord-293860-6kz0iws6 60 15 . . . cord-293860-6kz0iws6 61 1 It -PRON- PRP cord-293860-6kz0iws6 61 2 is be VBZ cord-293860-6kz0iws6 61 3 highly highly RB cord-293860-6kz0iws6 61 4 metabolised metabolise VBN cord-293860-6kz0iws6 61 5 in in IN cord-293860-6kz0iws6 61 6 the the DT cord-293860-6kz0iws6 61 7 liver liver NN cord-293860-6kz0iws6 61 8 by by IN cord-293860-6kz0iws6 61 9 cytochrome cytochrome NN cord-293860-6kz0iws6 61 10 P450 p450 NN cord-293860-6kz0iws6 61 11 . . . cord-293860-6kz0iws6 62 1 The the DT cord-293860-6kz0iws6 62 2 drug drug NN cord-293860-6kz0iws6 62 3 and and CC cord-293860-6kz0iws6 62 4 its -PRON- PRP$ cord-293860-6kz0iws6 62 5 metabolites metabolite NNS cord-293860-6kz0iws6 62 6 are be VBP cord-293860-6kz0iws6 62 7 almost almost RB cord-293860-6kz0iws6 62 8 exclusively exclusively RB cord-293860-6kz0iws6 62 9 excreted excrete VBN cord-293860-6kz0iws6 62 10 in in IN cord-293860-6kz0iws6 62 11 the the DT cord-293860-6kz0iws6 62 12 bile bile NN cord-293860-6kz0iws6 62 13 and and CC cord-293860-6kz0iws6 62 14 into into IN cord-293860-6kz0iws6 62 15 the the DT cord-293860-6kz0iws6 62 16 faeces faece NNS cord-293860-6kz0iws6 62 17 . . . cord-293860-6kz0iws6 63 1 With with IN cord-293860-6kz0iws6 63 2 its -PRON- PRP$ cord-293860-6kz0iws6 63 3 prominent prominent JJ cord-293860-6kz0iws6 63 4 effect effect NN cord-293860-6kz0iws6 63 5 in in IN cord-293860-6kz0iws6 63 6 reducing reduce VBG cord-293860-6kz0iws6 63 7 leukotriene leukotriene NN cord-293860-6kz0iws6 63 8 - - HYPH cord-293860-6kz0iws6 63 9 mediated mediate VBN cord-293860-6kz0iws6 63 10 cytokine cytokine NN cord-293860-6kz0iws6 63 11 release release NN cord-293860-6kz0iws6 63 12 montelukast montelukast NN cord-293860-6kz0iws6 63 13 would would MD cord-293860-6kz0iws6 63 14 have have VB cord-293860-6kz0iws6 63 15 the the DT cord-293860-6kz0iws6 63 16 potential potential NN cord-293860-6kz0iws6 63 17 to to TO cord-293860-6kz0iws6 63 18 moderate moderate VB cord-293860-6kz0iws6 63 19 the the DT cord-293860-6kz0iws6 63 20 background background NN cord-293860-6kz0iws6 63 21 inflammation inflammation NN cord-293860-6kz0iws6 63 22 associated associate VBN cord-293860-6kz0iws6 63 23 with with IN cord-293860-6kz0iws6 63 24 obesity obesity NN cord-293860-6kz0iws6 63 25 and and CC cord-293860-6kz0iws6 63 26 the the DT cord-293860-6kz0iws6 63 27 body body NN cord-293860-6kz0iws6 63 28 's 's POS cord-293860-6kz0iws6 63 29 inflammatory inflammatory JJ cord-293860-6kz0iws6 63 30 response response NN cord-293860-6kz0iws6 63 31 to to IN cord-293860-6kz0iws6 63 32 SARS SARS NNP cord-293860-6kz0iws6 63 33 - - HYPH cord-293860-6kz0iws6 63 34 CoV2 CoV2 NNP cord-293860-6kz0iws6 63 35 . . . cord-293860-6kz0iws6 64 1 Coronaviruses coronaviruse NNS cord-293860-6kz0iws6 64 2 are be VBP cord-293860-6kz0iws6 64 3 enveloped envelop VBN cord-293860-6kz0iws6 64 4 viruses virus NNS cord-293860-6kz0iws6 64 5 with with IN cord-293860-6kz0iws6 64 6 a a DT cord-293860-6kz0iws6 64 7 positive positive JJ cord-293860-6kz0iws6 64 8 RNA RNA NNP cord-293860-6kz0iws6 64 9 genome genome NN cord-293860-6kz0iws6 64 10 . . . cord-293860-6kz0iws6 65 1 The the DT cord-293860-6kz0iws6 65 2 virus virus NN cord-293860-6kz0iws6 65 3 contains contain VBZ cord-293860-6kz0iws6 65 4 at at IN cord-293860-6kz0iws6 65 5 least least RBS cord-293860-6kz0iws6 65 6 four four CD cord-293860-6kz0iws6 65 7 structural structural JJ cord-293860-6kz0iws6 65 8 proteins protein NNS cord-293860-6kz0iws6 65 9 : : : cord-293860-6kz0iws6 65 10 Spike spike NN cord-293860-6kz0iws6 65 11 ( ( -LRB- cord-293860-6kz0iws6 65 12 S s NN cord-293860-6kz0iws6 65 13 ) ) -RRB- cord-293860-6kz0iws6 65 14 protein protein NN cord-293860-6kz0iws6 65 15 , , , cord-293860-6kz0iws6 65 16 envelop envelop VB cord-293860-6kz0iws6 65 17 ( ( -LRB- cord-293860-6kz0iws6 65 18 E e NN cord-293860-6kz0iws6 65 19 ) ) -RRB- cord-293860-6kz0iws6 65 20 protein protein NN cord-293860-6kz0iws6 65 21 , , , cord-293860-6kz0iws6 65 22 membrane membrane NN cord-293860-6kz0iws6 65 23 ( ( -LRB- cord-293860-6kz0iws6 65 24 M M NNP cord-293860-6kz0iws6 65 25 ) ) -RRB- cord-293860-6kz0iws6 65 26 protein protein NN cord-293860-6kz0iws6 65 27 , , , cord-293860-6kz0iws6 65 28 and and CC cord-293860-6kz0iws6 65 29 nucleocapsid nucleocapsid NN cord-293860-6kz0iws6 65 30 ( ( -LRB- cord-293860-6kz0iws6 65 31 N N NNP cord-293860-6kz0iws6 65 32 ) ) -RRB- cord-293860-6kz0iws6 65 33 protein protein NN cord-293860-6kz0iws6 65 34 22 22 CD cord-293860-6kz0iws6 65 35 , , , cord-293860-6kz0iws6 65 36 23 23 CD cord-293860-6kz0iws6 65 37 . . . cord-293860-6kz0iws6 66 1 SARS SARS NNP cord-293860-6kz0iws6 66 2 - - HYPH cord-293860-6kz0iws6 66 3 CoV-2 CoV-2 NNP cord-293860-6kz0iws6 66 4 entry entry NN cord-293860-6kz0iws6 66 5 into into IN cord-293860-6kz0iws6 66 6 the the DT cord-293860-6kz0iws6 66 7 host host NN cord-293860-6kz0iws6 66 8 cells cell NNS cord-293860-6kz0iws6 66 9 is be VBZ cord-293860-6kz0iws6 66 10 mediated mediate VBN cord-293860-6kz0iws6 66 11 by by IN cord-293860-6kz0iws6 66 12 an an DT cord-293860-6kz0iws6 66 13 interaction interaction NN cord-293860-6kz0iws6 66 14 between between IN cord-293860-6kz0iws6 66 15 the the DT cord-293860-6kz0iws6 66 16 Spike Spike NNP cord-293860-6kz0iws6 66 17 protein protein NN cord-293860-6kz0iws6 66 18 and and CC cord-293860-6kz0iws6 66 19 angiotensin angiotensin NN cord-293860-6kz0iws6 66 20 - - HYPH cord-293860-6kz0iws6 66 21 converting convert VBG cord-293860-6kz0iws6 66 22 enzyme enzyme NN cord-293860-6kz0iws6 66 23 2 2 CD cord-293860-6kz0iws6 66 24 ( ( -LRB- cord-293860-6kz0iws6 66 25 ACE2 ACE2 NNP cord-293860-6kz0iws6 66 26 ) ) -RRB- cord-293860-6kz0iws6 66 27 receptors receptor NNS cord-293860-6kz0iws6 66 28 24 24 CD cord-293860-6kz0iws6 66 29 , , , cord-293860-6kz0iws6 66 30 25 25 CD cord-293860-6kz0iws6 66 31 , , , cord-293860-6kz0iws6 66 32 cell cell NN cord-293860-6kz0iws6 66 33 surface surface NN cord-293860-6kz0iws6 66 34 proteins protein NNS cord-293860-6kz0iws6 66 35 highly highly RB cord-293860-6kz0iws6 66 36 expressed express VBN cord-293860-6kz0iws6 66 37 in in IN cord-293860-6kz0iws6 66 38 the the DT cord-293860-6kz0iws6 66 39 lung lung NN cord-293860-6kz0iws6 66 40 , , , cord-293860-6kz0iws6 66 41 heart heart NN cord-293860-6kz0iws6 66 42 and and CC cord-293860-6kz0iws6 66 43 kidney kidney NN cord-293860-6kz0iws6 66 44 . . . cord-293860-6kz0iws6 67 1 Wu Wu NNP cord-293860-6kz0iws6 67 2 et et NNP cord-293860-6kz0iws6 67 3 al al NNP cord-293860-6kz0iws6 67 4 10 10 CD cord-293860-6kz0iws6 67 5 performed perform VBD cord-293860-6kz0iws6 67 6 in in IN cord-293860-6kz0iws6 67 7 silico silico NN cord-293860-6kz0iws6 67 8 , , , cord-293860-6kz0iws6 67 9 target target NN cord-293860-6kz0iws6 67 10 - - HYPH cord-293860-6kz0iws6 67 11 based base VBN cord-293860-6kz0iws6 67 12 virtual virtual JJ cord-293860-6kz0iws6 67 13 ligand ligand NN cord-293860-6kz0iws6 67 14 screening screening NN cord-293860-6kz0iws6 67 15 for for IN cord-293860-6kz0iws6 67 16 SARS SARS NNP cord-293860-6kz0iws6 67 17 - - HYPH cord-293860-6kz0iws6 67 18 CoV-2 CoV-2 NNP cord-293860-6kz0iws6 67 19 main main JJ cord-293860-6kz0iws6 67 20 proteins protein NNS cord-293860-6kz0iws6 67 21 including include VBG cord-293860-6kz0iws6 67 22 the the DT cord-293860-6kz0iws6 67 23 main main JJ cord-293860-6kz0iws6 67 24 protease protease NN cord-293860-6kz0iws6 67 25 , , , cord-293860-6kz0iws6 67 26 spike spike NN cord-293860-6kz0iws6 67 27 protein protein NN cord-293860-6kz0iws6 67 28 , , , cord-293860-6kz0iws6 67 29 RNA rna NN cord-293860-6kz0iws6 67 30 - - HYPH cord-293860-6kz0iws6 67 31 dependent dependent JJ cord-293860-6kz0iws6 67 32 RNA RNA NNP cord-293860-6kz0iws6 67 33 polymerase polymerase NN cord-293860-6kz0iws6 67 34 and and CC cord-293860-6kz0iws6 67 35 papain papain NN cord-293860-6kz0iws6 67 36 - - HYPH cord-293860-6kz0iws6 67 37 like like JJ cord-293860-6kz0iws6 67 38 protease protease NN cord-293860-6kz0iws6 67 39 . . . cord-293860-6kz0iws6 68 1 The the DT cord-293860-6kz0iws6 68 2 authors author NNS cord-293860-6kz0iws6 68 3 screened screen VBD cord-293860-6kz0iws6 68 4 approved approve VBN cord-293860-6kz0iws6 68 5 drugs drug NNS cord-293860-6kz0iws6 68 6 from from IN cord-293860-6kz0iws6 68 7 a a DT cord-293860-6kz0iws6 68 8 subset subset NN cord-293860-6kz0iws6 68 9 of of IN cord-293860-6kz0iws6 68 10 the the DT cord-293860-6kz0iws6 68 11 ZINC zinc NN cord-293860-6kz0iws6 68 12 database database NN cord-293860-6kz0iws6 68 13 which which WDT cord-293860-6kz0iws6 68 14 contains contain VBZ cord-293860-6kz0iws6 68 15 2924 2924 CD cord-293860-6kz0iws6 68 16 compounds compound NNS cord-293860-6kz0iws6 68 17 26 26 CD cord-293860-6kz0iws6 68 18 . . . cord-293860-6kz0iws6 69 1 They -PRON- PRP cord-293860-6kz0iws6 69 2 also also RB cord-293860-6kz0iws6 69 3 screened screen VBD cord-293860-6kz0iws6 69 4 a a DT cord-293860-6kz0iws6 69 5 natural natural JJ cord-293860-6kz0iws6 69 6 product product NN cord-293860-6kz0iws6 69 7 database database NN cord-293860-6kz0iws6 69 8 of of IN cord-293860-6kz0iws6 69 9 1,066 1,066 CD cord-293860-6kz0iws6 69 10 chemicals chemical NNS cord-293860-6kz0iws6 69 11 separated separate VBN cord-293860-6kz0iws6 69 12 from from IN cord-293860-6kz0iws6 69 13 traditional traditional JJ cord-293860-6kz0iws6 69 14 Chinese chinese JJ cord-293860-6kz0iws6 69 15 herbals herbal NNS cord-293860-6kz0iws6 69 16 and and CC cord-293860-6kz0iws6 69 17 78 78 CD cord-293860-6kz0iws6 69 18 known know VBN cord-293860-6kz0iws6 69 19 anti anti JJ cord-293860-6kz0iws6 69 20 - - JJ cord-293860-6kz0iws6 69 21 viral viral JJ cord-293860-6kz0iws6 69 22 drugs drug NNS cord-293860-6kz0iws6 69 23 . . . cord-293860-6kz0iws6 70 1 Their -PRON- PRP$ cord-293860-6kz0iws6 70 2 computer computer NN cord-293860-6kz0iws6 70 3 modelling modelling NN cord-293860-6kz0iws6 70 4 study study NN cord-293860-6kz0iws6 70 5 found find VBD cord-293860-6kz0iws6 70 6 that that IN cord-293860-6kz0iws6 70 7 montelukast montelukast NN cord-293860-6kz0iws6 70 8 should should MD cord-293860-6kz0iws6 70 9 demonstrate demonstrate VB cord-293860-6kz0iws6 70 10 binding bind VBG cord-293860-6kz0iws6 70 11 energy energy NN cord-293860-6kz0iws6 70 12 to to IN cord-293860-6kz0iws6 70 13 the the DT cord-293860-6kz0iws6 70 14 virus virus NN cord-293860-6kz0iws6 70 15 's 's POS cord-293860-6kz0iws6 70 16 main main JJ cord-293860-6kz0iws6 70 17 protease protease NN cord-293860-6kz0iws6 70 18 enzyme enzyme NN cord-293860-6kz0iws6 70 19 . . . cord-293860-6kz0iws6 71 1 It -PRON- PRP cord-293860-6kz0iws6 71 2 fitted fit VBD cord-293860-6kz0iws6 71 3 well well RB cord-293860-6kz0iws6 71 4 into into IN cord-293860-6kz0iws6 71 5 the the DT cord-293860-6kz0iws6 71 6 active active JJ cord-293860-6kz0iws6 71 7 pocket pocket NN cord-293860-6kz0iws6 71 8 of of IN cord-293860-6kz0iws6 71 9 the the DT cord-293860-6kz0iws6 71 10 main main JJ cord-293860-6kz0iws6 71 11 protease protease NN cord-293860-6kz0iws6 71 12 , , , cord-293860-6kz0iws6 71 13 in in IN cord-293860-6kz0iws6 71 14 which which WDT cord-293860-6kz0iws6 71 15 hydrophobic hydrophobic JJ cord-293860-6kz0iws6 71 16 amino amino NN cord-293860-6kz0iws6 71 17 acids acid NNS cord-293860-6kz0iws6 71 18 would would MD cord-293860-6kz0iws6 71 19 create create VB cord-293860-6kz0iws6 71 20 a a DT cord-293860-6kz0iws6 71 21 relatively relatively RB cord-293860-6kz0iws6 71 22 hydrophobic hydrophobic JJ cord-293860-6kz0iws6 71 23 environment environment NN cord-293860-6kz0iws6 71 24 to to TO cord-293860-6kz0iws6 71 25 contain contain VB cord-293860-6kz0iws6 71 26 the the DT cord-293860-6kz0iws6 71 27 drug drug NN cord-293860-6kz0iws6 71 28 and and CC cord-293860-6kz0iws6 71 29 stabilise stabilise VB cord-293860-6kz0iws6 71 30 its -PRON- PRP$ cord-293860-6kz0iws6 71 31 conformation conformation NN cord-293860-6kz0iws6 71 32 10 10 CD cord-293860-6kz0iws6 71 33 . . . cord-293860-6kz0iws6 72 1 Similarly similarly RB cord-293860-6kz0iws6 72 2 , , , cord-293860-6kz0iws6 72 3 a a DT cord-293860-6kz0iws6 72 4 report report NN cord-293860-6kz0iws6 72 5 by by IN cord-293860-6kz0iws6 72 6 Farag Farag NNP cord-293860-6kz0iws6 72 7 et et NNP cord-293860-6kz0iws6 72 8 al al NNP cord-293860-6kz0iws6 72 9 11 11 CD cord-293860-6kz0iws6 72 10 predicted predict VBD cord-293860-6kz0iws6 72 11 a a DT cord-293860-6kz0iws6 72 12 high high JJ cord-293860-6kz0iws6 72 13 affinity affinity NN cord-293860-6kz0iws6 72 14 of of IN cord-293860-6kz0iws6 72 15 montelukast montelukast NN cord-293860-6kz0iws6 72 16 to to IN cord-293860-6kz0iws6 72 17 the the DT cord-293860-6kz0iws6 72 18 same same JJ cord-293860-6kz0iws6 72 19 binding bind VBG cord-293860-6kz0iws6 72 20 domain domain NN cord-293860-6kz0iws6 72 21 in in IN cord-293860-6kz0iws6 72 22 the the DT cord-293860-6kz0iws6 72 23 main main JJ cord-293860-6kz0iws6 72 24 protease protease NN cord-293860-6kz0iws6 72 25 enzyme enzyme NN cord-293860-6kz0iws6 72 26 with with IN cord-293860-6kz0iws6 72 27 hydrophobic hydrophobic JJ cord-293860-6kz0iws6 72 28 - - HYPH cord-293860-6kz0iws6 72 29 hydrophobic hydrophobic JJ cord-293860-6kz0iws6 72 30 and and CC cord-293860-6kz0iws6 72 31 hydrogen hydrogen NN cord-293860-6kz0iws6 72 32 bond bond NN cord-293860-6kz0iws6 72 33 - - HYPH cord-293860-6kz0iws6 72 34 interactions interaction NNS cord-293860-6kz0iws6 72 35 . . . cord-293860-6kz0iws6 73 1 Farag Farag NNP cord-293860-6kz0iws6 73 2 et et NNP cord-293860-6kz0iws6 73 3 al al NNP cord-293860-6kz0iws6 73 4 11 11 CD cord-293860-6kz0iws6 73 5 focussed focusse VBD cord-293860-6kz0iws6 73 6 on on IN cord-293860-6kz0iws6 73 7 targeting target VBG cord-293860-6kz0iws6 73 8 the the DT cord-293860-6kz0iws6 73 9 SARS SARS NNP cord-293860-6kz0iws6 73 10 - - HYPH cord-293860-6kz0iws6 73 11 CoV-2 CoV-2 NNP cord-293860-6kz0iws6 73 12 main main JJ cord-293860-6kz0iws6 73 13 protease protease NN cord-293860-6kz0iws6 73 14 enzyme enzyme NN cord-293860-6kz0iws6 73 15 at at IN cord-293860-6kz0iws6 73 16 its -PRON- PRP$ cord-293860-6kz0iws6 73 17 two two CD cord-293860-6kz0iws6 73 18 potential potential JJ cord-293860-6kz0iws6 73 19 binding bind VBG cord-293860-6kz0iws6 73 20 sites site NNS cord-293860-6kz0iws6 73 21 in in IN cord-293860-6kz0iws6 73 22 the the DT cord-293860-6kz0iws6 73 23 main main JJ cord-293860-6kz0iws6 73 24 substrate substrate NN cord-293860-6kz0iws6 73 25 - - HYPH cord-293860-6kz0iws6 73 26 binding bind VBG cord-293860-6kz0iws6 73 27 pocket pocket NN cord-293860-6kz0iws6 73 28 : : : cord-293860-6kz0iws6 73 29 the the DT cord-293860-6kz0iws6 73 30 central central JJ cord-293860-6kz0iws6 73 31 site site NN cord-293860-6kz0iws6 73 32 and and CC cord-293860-6kz0iws6 73 33 terminal terminal NN cord-293860-6kz0iws6 73 34 site site NN cord-293860-6kz0iws6 73 35 . . . cord-293860-6kz0iws6 74 1 The the DT cord-293860-6kz0iws6 74 2 authors author NNS cord-293860-6kz0iws6 74 3 screened screen VBD cord-293860-6kz0iws6 74 4 > > XX cord-293860-6kz0iws6 74 5 2,000 2,000 CD cord-293860-6kz0iws6 74 6 FDA FDA NNP cord-293860-6kz0iws6 74 7 - - HYPH cord-293860-6kz0iws6 74 8 approved approve VBN cord-293860-6kz0iws6 74 9 drugs drug NNS cord-293860-6kz0iws6 74 10 to to TO cord-293860-6kz0iws6 74 11 identify identify VB cord-293860-6kz0iws6 74 12 potential potential JJ cord-293860-6kz0iws6 74 13 hits hit NNS cord-293860-6kz0iws6 74 14 based base VBN cord-293860-6kz0iws6 74 15 on on IN cord-293860-6kz0iws6 74 16 drug drug NN cord-293860-6kz0iws6 74 17 molecules molecule NNS cord-293860-6kz0iws6 74 18 ' ' POS cord-293860-6kz0iws6 74 19 binding bind VBG cord-293860-6kz0iws6 74 20 energies energy NNS cord-293860-6kz0iws6 74 21 , , , cord-293860-6kz0iws6 74 22 binding bind VBG cord-293860-6kz0iws6 74 23 modes mode NNS cord-293860-6kz0iws6 74 24 and and CC cord-293860-6kz0iws6 74 25 the the DT cord-293860-6kz0iws6 74 26 predicted predict VBN cord-293860-6kz0iws6 74 27 interaction interaction NN cord-293860-6kz0iws6 74 28 of of IN cord-293860-6kz0iws6 74 29 amino amino JJ cord-293860-6kz0iws6 74 30 acids acid NNS cord-293860-6kz0iws6 74 31 with with IN cord-293860-6kz0iws6 74 32 the the DT cord-293860-6kz0iws6 74 33 enzyme enzyme NN cord-293860-6kz0iws6 74 34 's 's POS cord-293860-6kz0iws6 74 35 substrate substrate NN cord-293860-6kz0iws6 74 36 binding bind VBG cord-293860-6kz0iws6 74 37 pockets pocket NNS cord-293860-6kz0iws6 74 38 . . . cord-293860-6kz0iws6 75 1 Whilst whilst IN cord-293860-6kz0iws6 75 2 antiviral antiviral JJ cord-293860-6kz0iws6 75 3 drugs drug NNS cord-293860-6kz0iws6 75 4 unsurprisingly unsurprisingly RB cord-293860-6kz0iws6 75 5 had have VBD cord-293860-6kz0iws6 75 6 the the DT cord-293860-6kz0iws6 75 7 best good JJS cord-293860-6kz0iws6 75 8 binding binding NN cord-293860-6kz0iws6 75 9 to to IN cord-293860-6kz0iws6 75 10 the the DT cord-293860-6kz0iws6 75 11 central central JJ cord-293860-6kz0iws6 75 12 site site NN cord-293860-6kz0iws6 75 13 of of IN cord-293860-6kz0iws6 75 14 the the DT cord-293860-6kz0iws6 75 15 main main JJ cord-293860-6kz0iws6 75 16 protease protease NN cord-293860-6kz0iws6 75 17 enzyme enzyme NN cord-293860-6kz0iws6 75 18 substrate substrate NN cord-293860-6kz0iws6 75 19 - - HYPH cord-293860-6kz0iws6 75 20 binding bind VBG cord-293860-6kz0iws6 75 21 pocket pocket NN cord-293860-6kz0iws6 75 22 , , , cord-293860-6kz0iws6 75 23 montelukast montelukast NNP cord-293860-6kz0iws6 75 24 demonstrated demonstrate VBD cord-293860-6kz0iws6 75 25 a a DT cord-293860-6kz0iws6 75 26 very very RB cord-293860-6kz0iws6 75 27 high high JJ cord-293860-6kz0iws6 75 28 affinity affinity NN cord-293860-6kz0iws6 75 29 for for IN cord-293860-6kz0iws6 75 30 the the DT cord-293860-6kz0iws6 75 31 terminal terminal JJ cord-293860-6kz0iws6 75 32 site site NN cord-293860-6kz0iws6 75 33 , , , cord-293860-6kz0iws6 75 34 better well JJR cord-293860-6kz0iws6 75 35 than than IN cord-293860-6kz0iws6 75 36 any any DT cord-293860-6kz0iws6 75 37 other other JJ cord-293860-6kz0iws6 75 38 drug drug NN cord-293860-6kz0iws6 75 39 tested test VBN cord-293860-6kz0iws6 75 40 at at IN cord-293860-6kz0iws6 75 41 this this DT cord-293860-6kz0iws6 75 42 site site NN cord-293860-6kz0iws6 75 43 Whist Whist NNP cord-293860-6kz0iws6 75 44 drug drug NN cord-293860-6kz0iws6 75 45 binding bind VBG cord-293860-6kz0iws6 75 46 in in RP cord-293860-6kz0iws6 75 47 in in IN cord-293860-6kz0iws6 75 48 silico silico NN cord-293860-6kz0iws6 75 49 modelling modelling NN cord-293860-6kz0iws6 75 50 studies study NNS cord-293860-6kz0iws6 75 51 such such JJ cord-293860-6kz0iws6 75 52 as as IN cord-293860-6kz0iws6 75 53 these these DT cord-293860-6kz0iws6 75 54 may may MD cord-293860-6kz0iws6 75 55 not not RB cord-293860-6kz0iws6 75 56 translate translate VB cord-293860-6kz0iws6 75 57 into into IN cord-293860-6kz0iws6 75 58 clinical clinical JJ cord-293860-6kz0iws6 75 59 effect effect NN cord-293860-6kz0iws6 75 60 , , , cord-293860-6kz0iws6 75 61 the the DT cord-293860-6kz0iws6 75 62 protease protease NN cord-293860-6kz0iws6 75 63 enzyme enzyme NN cord-293860-6kz0iws6 75 64 is be VBZ cord-293860-6kz0iws6 75 65 essential essential JJ cord-293860-6kz0iws6 75 66 for for IN cord-293860-6kz0iws6 75 67 the the DT cord-293860-6kz0iws6 75 68 SARS SARS NNP cord-293860-6kz0iws6 75 69 - - HYPH cord-293860-6kz0iws6 75 70 CoV-2 CoV-2 NNP cord-293860-6kz0iws6 75 71 virus virus NN cord-293860-6kz0iws6 75 72 RNA rna NN cord-293860-6kz0iws6 75 73 synthesis synthesis NN cord-293860-6kz0iws6 75 74 and and CC cord-293860-6kz0iws6 75 75 replication replication NN cord-293860-6kz0iws6 75 76 and and CC cord-293860-6kz0iws6 75 77 if if IN cord-293860-6kz0iws6 75 78 montelukast montelukast NNP cord-293860-6kz0iws6 75 79 was be VBD cord-293860-6kz0iws6 75 80 shown show VBN cord-293860-6kz0iws6 75 81 to to TO cord-293860-6kz0iws6 75 82 confer confer VB cord-293860-6kz0iws6 75 83 benefit benefit NN cord-293860-6kz0iws6 75 84 in in IN cord-293860-6kz0iws6 75 85 clinical clinical JJ cord-293860-6kz0iws6 75 86 studies study NNS cord-293860-6kz0iws6 75 87 it -PRON- PRP cord-293860-6kz0iws6 75 88 may may MD cord-293860-6kz0iws6 75 89 be be VB cord-293860-6kz0iws6 75 90 , , , cord-293860-6kz0iws6 75 91 at at IN cord-293860-6kz0iws6 75 92 least least JJS cord-293860-6kz0iws6 75 93 in in IN cord-293860-6kz0iws6 75 94 part part NN cord-293860-6kz0iws6 75 95 , , , cord-293860-6kz0iws6 75 96 due due JJ cord-293860-6kz0iws6 75 97 drug drug NN cord-293860-6kz0iws6 75 98 - - HYPH cord-293860-6kz0iws6 75 99 induced induce VBN cord-293860-6kz0iws6 75 100 disruption disruption NN cord-293860-6kz0iws6 75 101 of of IN cord-293860-6kz0iws6 75 102 the the DT cord-293860-6kz0iws6 75 103 virus virus NN cord-293860-6kz0iws6 75 104 replication replication NN cord-293860-6kz0iws6 75 105 cycle cycle NN cord-293860-6kz0iws6 75 106 . . . cord-293860-6kz0iws6 76 1 One one CD cord-293860-6kz0iws6 76 2 of of IN cord-293860-6kz0iws6 76 3 the the DT cord-293860-6kz0iws6 76 4 main main JJ cord-293860-6kz0iws6 76 5 treatment treatment NN cord-293860-6kz0iws6 76 6 strategies strategy NNS cord-293860-6kz0iws6 76 7 for for IN cord-293860-6kz0iws6 76 8 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 76 9 is be VBZ cord-293860-6kz0iws6 76 10 to to TO cord-293860-6kz0iws6 76 11 identify identify VB cord-293860-6kz0iws6 76 12 new new JJ cord-293860-6kz0iws6 76 13 targeted target VBN cord-293860-6kz0iws6 76 14 antiviral antiviral JJ cord-293860-6kz0iws6 76 15 drugs drug NNS cord-293860-6kz0iws6 76 16 based base VBN cord-293860-6kz0iws6 76 17 on on IN cord-293860-6kz0iws6 76 18 the the DT cord-293860-6kz0iws6 76 19 genomic genomic JJ cord-293860-6kz0iws6 76 20 information information NN cord-293860-6kz0iws6 76 21 and and CC cord-293860-6kz0iws6 76 22 pathological pathological JJ cord-293860-6kz0iws6 76 23 characteristics characteristic NNS cord-293860-6kz0iws6 76 24 of of IN cord-293860-6kz0iws6 76 25 SARS SARS NNP cord-293860-6kz0iws6 76 26 - - HYPH cord-293860-6kz0iws6 76 27 CoV-2 CoV-2 NNP cord-293860-6kz0iws6 76 28 . . . cord-293860-6kz0iws6 77 1 These these DT cord-293860-6kz0iws6 77 2 drugs drug NNS cord-293860-6kz0iws6 77 3 are be VBP cord-293860-6kz0iws6 77 4 likely likely JJ cord-293860-6kz0iws6 77 5 to to TO cord-293860-6kz0iws6 77 6 be be VB cord-293860-6kz0iws6 77 7 the the DT cord-293860-6kz0iws6 77 8 most most RBS cord-293860-6kz0iws6 77 9 effective effective JJ cord-293860-6kz0iws6 77 10 against against IN cord-293860-6kz0iws6 77 11 the the DT cord-293860-6kz0iws6 77 12 virus virus NN cord-293860-6kz0iws6 77 13 . . . cord-293860-6kz0iws6 78 1 However however RB cord-293860-6kz0iws6 78 2 , , , cord-293860-6kz0iws6 78 3 anti anti JJ cord-293860-6kz0iws6 78 4 - - JJ cord-293860-6kz0iws6 78 5 viral viral JJ cord-293860-6kz0iws6 78 6 drug drug NN cord-293860-6kz0iws6 78 7 development development NN cord-293860-6kz0iws6 78 8 and and CC cord-293860-6kz0iws6 78 9 registration registration NN cord-293860-6kz0iws6 78 10 is be VBZ cord-293860-6kz0iws6 78 11 time time NN cord-293860-6kz0iws6 78 12 - - HYPH cord-293860-6kz0iws6 78 13 consuming consume VBG cord-293860-6kz0iws6 78 14 , , , cord-293860-6kz0iws6 78 15 the the DT cord-293860-6kz0iws6 78 16 drug drug NN cord-293860-6kz0iws6 78 17 might may MD cord-293860-6kz0iws6 78 18 not not RB cord-293860-6kz0iws6 78 19 be be VB cord-293860-6kz0iws6 78 20 available available JJ cord-293860-6kz0iws6 78 21 for for IN cord-293860-6kz0iws6 78 22 the the DT cord-293860-6kz0iws6 78 23 current current JJ cord-293860-6kz0iws6 78 24 outbreak outbreak NN cord-293860-6kz0iws6 78 25 and and CC cord-293860-6kz0iws6 78 26 it -PRON- PRP cord-293860-6kz0iws6 78 27 is be VBZ cord-293860-6kz0iws6 78 28 likely likely JJ cord-293860-6kz0iws6 78 29 to to TO cord-293860-6kz0iws6 78 30 be be VB cord-293860-6kz0iws6 78 31 very very RB cord-293860-6kz0iws6 78 32 expensive expensive JJ cord-293860-6kz0iws6 78 33 , , , cord-293860-6kz0iws6 78 34 an an DT cord-293860-6kz0iws6 78 35 important important JJ cord-293860-6kz0iws6 78 36 factor factor NN cord-293860-6kz0iws6 78 37 particularly particularly RB cord-293860-6kz0iws6 78 38 in in IN cord-293860-6kz0iws6 78 39 poorer poor JJR cord-293860-6kz0iws6 78 40 countries country NNS cord-293860-6kz0iws6 78 41 afflicted afflict VBN cord-293860-6kz0iws6 78 42 by by IN cord-293860-6kz0iws6 78 43 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 78 44 . . . cord-293860-6kz0iws6 79 1 An an DT cord-293860-6kz0iws6 79 2 alternative alternative NN cord-293860-6kz0iws6 79 3 , , , cord-293860-6kz0iws6 79 4 faster fast JJR cord-293860-6kz0iws6 79 5 strategy strategy NN cord-293860-6kz0iws6 79 6 is be VBZ cord-293860-6kz0iws6 79 7 ' ' `` cord-293860-6kz0iws6 79 8 drug drug NN cord-293860-6kz0iws6 79 9 repurposing repurposing NN cord-293860-6kz0iws6 79 10 ' ' '' cord-293860-6kz0iws6 79 11 . . . cord-293860-6kz0iws6 80 1 This this DT cord-293860-6kz0iws6 80 2 relies rely VBZ cord-293860-6kz0iws6 80 3 on on IN cord-293860-6kz0iws6 80 4 identification identification NN cord-293860-6kz0iws6 80 5 of of IN cord-293860-6kz0iws6 80 6 potential potential JJ cord-293860-6kz0iws6 80 7 therapeutic therapeutic JJ cord-293860-6kz0iws6 80 8 characteristics characteristic NNS cord-293860-6kz0iws6 80 9 of of IN cord-293860-6kz0iws6 80 10 drugs drug NNS cord-293860-6kz0iws6 80 11 currently currently RB cord-293860-6kz0iws6 80 12 licensed license VBN cord-293860-6kz0iws6 80 13 for for IN cord-293860-6kz0iws6 80 14 other other JJ cord-293860-6kz0iws6 80 15 purposes purpose NNS cord-293860-6kz0iws6 80 16 . . . cord-293860-6kz0iws6 81 1 There there EX cord-293860-6kz0iws6 81 2 are be VBP cord-293860-6kz0iws6 81 3 many many JJ cord-293860-6kz0iws6 81 4 clinical clinical JJ cord-293860-6kz0iws6 81 5 trials trial NNS cord-293860-6kz0iws6 81 6 enrolling enrol VBG cord-293860-6kz0iws6 81 7 patients patient NNS cord-293860-6kz0iws6 81 8 with with IN cord-293860-6kz0iws6 81 9 COVID-19 COVID-19 , cord-293860-6kz0iws6 81 10 worldwide worldwide RB cord-293860-6kz0iws6 81 11 investigating investigate VBG cord-293860-6kz0iws6 81 12 the the DT cord-293860-6kz0iws6 81 13 potential potential JJ cord-293860-6kz0iws6 81 14 benefits benefit NNS cord-293860-6kz0iws6 81 15 of of IN cord-293860-6kz0iws6 81 16 established establish VBN cord-293860-6kz0iws6 81 17 antimicrobial antimicrobial JJ cord-293860-6kz0iws6 81 18 , , , cord-293860-6kz0iws6 81 19 antiviral antiviral JJ cord-293860-6kz0iws6 81 20 and and CC cord-293860-6kz0iws6 81 21 anti anti JJ cord-293860-6kz0iws6 81 22 - - JJ cord-293860-6kz0iws6 81 23 inflammatory inflammatory JJ cord-293860-6kz0iws6 81 24 drugs drug NNS cord-293860-6kz0iws6 81 25 27 27 CD cord-293860-6kz0iws6 81 26 . . . cord-293860-6kz0iws6 82 1 The the DT cord-293860-6kz0iws6 82 2 strong strong JJ cord-293860-6kz0iws6 82 3 association association NN cord-293860-6kz0iws6 82 4 between between IN cord-293860-6kz0iws6 82 5 the the DT cord-293860-6kz0iws6 82 6 pro pro JJ cord-293860-6kz0iws6 82 7 - - JJ cord-293860-6kz0iws6 82 8 inflammatory inflammatory JJ cord-293860-6kz0iws6 82 9 state state NN cord-293860-6kz0iws6 82 10 found find VBN cord-293860-6kz0iws6 82 11 in in IN cord-293860-6kz0iws6 82 12 metabolic metabolic JJ cord-293860-6kz0iws6 82 13 syndrome syndrome NN cord-293860-6kz0iws6 82 14 and and CC cord-293860-6kz0iws6 82 15 obesity obesity NN cord-293860-6kz0iws6 82 16 and and CC cord-293860-6kz0iws6 82 17 a a DT cord-293860-6kz0iws6 82 18 more more RBR cord-293860-6kz0iws6 82 19 aggressive aggressive JJ cord-293860-6kz0iws6 82 20 clinical clinical JJ cord-293860-6kz0iws6 82 21 course course NN cord-293860-6kz0iws6 82 22 in in IN cord-293860-6kz0iws6 82 23 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 82 24 suggests suggest VBZ cord-293860-6kz0iws6 82 25 a a DT cord-293860-6kz0iws6 82 26 potential potential JJ cord-293860-6kz0iws6 82 27 treatment treatment NN cord-293860-6kz0iws6 82 28 role role NN cord-293860-6kz0iws6 82 29 for for IN cord-293860-6kz0iws6 82 30 drugs drug NNS cord-293860-6kz0iws6 82 31 that that WDT cord-293860-6kz0iws6 82 32 inhibit inhibit VBP cord-293860-6kz0iws6 82 33 cytokine cytokine NN cord-293860-6kz0iws6 82 34 release release NN cord-293860-6kz0iws6 82 35 and and CC cord-293860-6kz0iws6 82 36 macrophage macrophage NN cord-293860-6kz0iws6 82 37 activation activation NN cord-293860-6kz0iws6 82 38 . . . cord-293860-6kz0iws6 83 1 There there EX cord-293860-6kz0iws6 83 2 is be VBZ cord-293860-6kz0iws6 83 3 , , , cord-293860-6kz0iws6 83 4 however however RB cord-293860-6kz0iws6 83 5 , , , cord-293860-6kz0iws6 83 6 so so RB cord-293860-6kz0iws6 83 7 far far RB cord-293860-6kz0iws6 83 8 no no DT cord-293860-6kz0iws6 83 9 convincing convincing JJ cord-293860-6kz0iws6 83 10 clinical clinical JJ cord-293860-6kz0iws6 83 11 evidence evidence NN cord-293860-6kz0iws6 83 12 to to TO cord-293860-6kz0iws6 83 13 support support VB cord-293860-6kz0iws6 83 14 the the DT cord-293860-6kz0iws6 83 15 use use NN cord-293860-6kz0iws6 83 16 of of IN cord-293860-6kz0iws6 83 17 corticosteroids corticosteroid NNS cord-293860-6kz0iws6 83 18 , , , cord-293860-6kz0iws6 83 19 one one CD cord-293860-6kz0iws6 83 20 of of IN cord-293860-6kz0iws6 83 21 the the DT cord-293860-6kz0iws6 83 22 most most RBS cord-293860-6kz0iws6 83 23 widely widely RB cord-293860-6kz0iws6 83 24 utilised utilise VBN cord-293860-6kz0iws6 83 25 anti anti JJ cord-293860-6kz0iws6 83 26 - - JJ cord-293860-6kz0iws6 83 27 inflammatory inflammatory JJ cord-293860-6kz0iws6 83 28 agents agent NNS cord-293860-6kz0iws6 83 29 . . . cord-293860-6kz0iws6 84 1 If if IN cord-293860-6kz0iws6 84 2 anything anything NN cord-293860-6kz0iws6 84 3 , , , cord-293860-6kz0iws6 84 4 there there EX cord-293860-6kz0iws6 84 5 is be VBZ cord-293860-6kz0iws6 84 6 concern concern NN cord-293860-6kz0iws6 84 7 about about IN cord-293860-6kz0iws6 84 8 patients patient NNS cord-293860-6kz0iws6 84 9 being be VBG cord-293860-6kz0iws6 84 10 harmed harm VBN cord-293860-6kz0iws6 84 11 with with IN cord-293860-6kz0iws6 84 12 such such PDT cord-293860-6kz0iws6 84 13 a a DT cord-293860-6kz0iws6 84 14 treatment treatment NN cord-293860-6kz0iws6 84 15 28 28 CD cord-293860-6kz0iws6 84 16 , , , cord-293860-6kz0iws6 84 17 29 29 CD cord-293860-6kz0iws6 84 18 . . . cord-293860-6kz0iws6 85 1 Anti Anti NNS cord-293860-6kz0iws6 85 2 - - NNS cord-293860-6kz0iws6 85 3 cytokines cytokine NNS cord-293860-6kz0iws6 86 1 ( ( -LRB- cord-293860-6kz0iws6 86 2 interleukin interleukin NN cord-293860-6kz0iws6 86 3 6 6 CD cord-293860-6kz0iws6 86 4 inhibitors inhibitor NNS cord-293860-6kz0iws6 86 5 , , , cord-293860-6kz0iws6 86 6 e.g. e.g. RB cord-293860-6kz0iws6 86 7 , , , cord-293860-6kz0iws6 86 8 tocilizumab tocilizumab NN cord-293860-6kz0iws6 86 9 ) ) -RRB- cord-293860-6kz0iws6 86 10 have have VBP cord-293860-6kz0iws6 86 11 also also RB cord-293860-6kz0iws6 86 12 attracted attract VBN cord-293860-6kz0iws6 86 13 much much JJ cord-293860-6kz0iws6 86 14 interest interest NN cord-293860-6kz0iws6 86 15 recently recently RB cord-293860-6kz0iws6 86 16 30 30 CD cord-293860-6kz0iws6 86 17 with with IN cord-293860-6kz0iws6 86 18 a a DT cord-293860-6kz0iws6 86 19 few few JJ cord-293860-6kz0iws6 86 20 ongoing ongoing JJ cord-293860-6kz0iws6 86 21 clinical clinical JJ cord-293860-6kz0iws6 86 22 trials trial NNS cord-293860-6kz0iws6 86 23 assessing assess VBG cord-293860-6kz0iws6 86 24 their -PRON- PRP$ cord-293860-6kz0iws6 86 25 role role NN cord-293860-6kz0iws6 86 26 27 27 CD cord-293860-6kz0iws6 86 27 . . . cord-293860-6kz0iws6 87 1 However however RB cord-293860-6kz0iws6 87 2 , , , cord-293860-6kz0iws6 87 3 these these DT cord-293860-6kz0iws6 87 4 monoclonal monoclonal JJ cord-293860-6kz0iws6 87 5 antibodies antibody NNS cord-293860-6kz0iws6 87 6 are be VBP cord-293860-6kz0iws6 87 7 expensive expensive JJ cord-293860-6kz0iws6 87 8 and and CC cord-293860-6kz0iws6 87 9 like like IN cord-293860-6kz0iws6 87 10 corticosteroids corticosteroid NNS cord-293860-6kz0iws6 87 11 have have VBP cord-293860-6kz0iws6 87 12 the the DT cord-293860-6kz0iws6 87 13 potential potential NN cord-293860-6kz0iws6 87 14 for for IN cord-293860-6kz0iws6 87 15 promoting promote VBG cord-293860-6kz0iws6 87 16 secondary secondary JJ cord-293860-6kz0iws6 87 17 infections infection NNS cord-293860-6kz0iws6 87 18 . . . cord-293860-6kz0iws6 88 1 Cost cost NN cord-293860-6kz0iws6 88 2 and and CC cord-293860-6kz0iws6 88 3 complications complication NNS cord-293860-6kz0iws6 88 4 are be VBP cord-293860-6kz0iws6 88 5 likely likely JJ cord-293860-6kz0iws6 88 6 to to TO cord-293860-6kz0iws6 88 7 limit limit VB cord-293860-6kz0iws6 88 8 their -PRON- PRP$ cord-293860-6kz0iws6 88 9 application application NN cord-293860-6kz0iws6 88 10 on on IN cord-293860-6kz0iws6 88 11 a a DT cord-293860-6kz0iws6 88 12 global global JJ cord-293860-6kz0iws6 88 13 scale scale NN cord-293860-6kz0iws6 88 14 , , , cord-293860-6kz0iws6 88 15 other other JJ cord-293860-6kz0iws6 88 16 than than IN cord-293860-6kz0iws6 88 17 selective selective JJ cord-293860-6kz0iws6 88 18 use use NN cord-293860-6kz0iws6 88 19 in in IN cord-293860-6kz0iws6 88 20 severely severely RB cord-293860-6kz0iws6 88 21 ill ill JJ cord-293860-6kz0iws6 88 22 patients patient NNS cord-293860-6kz0iws6 88 23 30 30 CD cord-293860-6kz0iws6 88 24 , , , cord-293860-6kz0iws6 88 25 31 31 CD cord-293860-6kz0iws6 88 26 . . . cord-293860-6kz0iws6 89 1 We -PRON- PRP cord-293860-6kz0iws6 89 2 believe believe VBP cord-293860-6kz0iws6 89 3 there there EX cord-293860-6kz0iws6 89 4 is be VBZ cord-293860-6kz0iws6 89 5 a a DT cord-293860-6kz0iws6 89 6 good good JJ cord-293860-6kz0iws6 89 7 theoretical theoretical JJ cord-293860-6kz0iws6 89 8 basis basis NN cord-293860-6kz0iws6 89 9 to to TO cord-293860-6kz0iws6 89 10 consider consider VB cord-293860-6kz0iws6 89 11 montelukast montelukast NNP cord-293860-6kz0iws6 89 12 as as IN cord-293860-6kz0iws6 89 13 a a DT cord-293860-6kz0iws6 89 14 therapeutic therapeutic JJ cord-293860-6kz0iws6 89 15 candidate candidate NN cord-293860-6kz0iws6 89 16 with with IN cord-293860-6kz0iws6 89 17 a a DT cord-293860-6kz0iws6 89 18 hypothetical hypothetical JJ cord-293860-6kz0iws6 89 19 dual dual JJ cord-293860-6kz0iws6 89 20 mode mode NN cord-293860-6kz0iws6 89 21 of of IN cord-293860-6kz0iws6 89 22 action action NN cord-293860-6kz0iws6 89 23 through through IN cord-293860-6kz0iws6 89 24 suppression suppression NN cord-293860-6kz0iws6 89 25 of of IN cord-293860-6kz0iws6 89 26 cytokine cytokine NN cord-293860-6kz0iws6 89 27 activity activity NN cord-293860-6kz0iws6 89 28 and and CC cord-293860-6kz0iws6 89 29 interference interference NN cord-293860-6kz0iws6 89 30 with with IN cord-293860-6kz0iws6 89 31 viral viral JJ cord-293860-6kz0iws6 89 32 replication replication NN cord-293860-6kz0iws6 89 33 . . . cord-293860-6kz0iws6 90 1 To to IN cord-293860-6kz0iws6 90 2 date date NN cord-293860-6kz0iws6 90 3 , , , cord-293860-6kz0iws6 90 4 the the DT cord-293860-6kz0iws6 90 5 Cochrane Cochrane NNP cord-293860-6kz0iws6 90 6 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 90 7 Study Study NNP cord-293860-6kz0iws6 90 8 Register Register NNP cord-293860-6kz0iws6 90 9 does do VBZ cord-293860-6kz0iws6 90 10 not not RB cord-293860-6kz0iws6 90 11 identify identify VB cord-293860-6kz0iws6 90 12 any any DT cord-293860-6kz0iws6 90 13 studies study NNS cord-293860-6kz0iws6 90 14 exploring explore VBG cord-293860-6kz0iws6 90 15 the the DT cord-293860-6kz0iws6 90 16 clinical clinical JJ cord-293860-6kz0iws6 90 17 benefits benefit NNS cord-293860-6kz0iws6 90 18 of of IN cord-293860-6kz0iws6 90 19 montelukast montelukast NNP cord-293860-6kz0iws6 90 20 . . . cord-293860-6kz0iws6 91 1 Whilst whilst IN cord-293860-6kz0iws6 91 2 it -PRON- PRP cord-293860-6kz0iws6 91 3 is be VBZ cord-293860-6kz0iws6 91 4 unlikely unlikely JJ cord-293860-6kz0iws6 91 5 that that IN cord-293860-6kz0iws6 91 6 montelukast montelukast NN cord-293860-6kz0iws6 91 7 would would MD cord-293860-6kz0iws6 91 8 be be VB cord-293860-6kz0iws6 91 9 effective effective JJ cord-293860-6kz0iws6 91 10 at at IN cord-293860-6kz0iws6 91 11 curing cure VBG cord-293860-6kz0iws6 91 12 COVID-19 covid-19 VB cord-293860-6kz0iws6 91 13 or or CC cord-293860-6kz0iws6 91 14 reversing reverse VBG cord-293860-6kz0iws6 91 15 severe severe JJ cord-293860-6kz0iws6 91 16 immune immune NN cord-293860-6kz0iws6 91 17 - - HYPH cord-293860-6kz0iws6 91 18 modulated modulate VBN cord-293860-6kz0iws6 91 19 multiorgan multiorgan NN cord-293860-6kz0iws6 91 20 damage damage NN cord-293860-6kz0iws6 91 21 , , , cord-293860-6kz0iws6 91 22 it -PRON- PRP cord-293860-6kz0iws6 91 23 could could MD cord-293860-6kz0iws6 91 24 have have VB cord-293860-6kz0iws6 91 25 a a DT cord-293860-6kz0iws6 91 26 powerful powerful JJ cord-293860-6kz0iws6 91 27 role role NN cord-293860-6kz0iws6 91 28 in in IN cord-293860-6kz0iws6 91 29 preventing prevent VBG cord-293860-6kz0iws6 91 30 disease disease NN cord-293860-6kz0iws6 91 31 progression progression NN cord-293860-6kz0iws6 91 32 when when WRB cord-293860-6kz0iws6 91 33 used use VBN cord-293860-6kz0iws6 91 34 at at IN cord-293860-6kz0iws6 91 35 an an DT cord-293860-6kz0iws6 91 36 early early JJ cord-293860-6kz0iws6 91 37 stage stage NN cord-293860-6kz0iws6 91 38 in in IN cord-293860-6kz0iws6 91 39 the the DT cord-293860-6kz0iws6 91 40 disease disease NN cord-293860-6kz0iws6 91 41 , , , cord-293860-6kz0iws6 91 42 reducing reduce VBG cord-293860-6kz0iws6 91 43 the the DT cord-293860-6kz0iws6 91 44 need need NN cord-293860-6kz0iws6 91 45 for for IN cord-293860-6kz0iws6 91 46 hospital hospital NN cord-293860-6kz0iws6 91 47 admission admission NN cord-293860-6kz0iws6 91 48 , , , cord-293860-6kz0iws6 91 49 or or CC cord-293860-6kz0iws6 92 1 the the DT cord-293860-6kz0iws6 92 2 requirement requirement NN cord-293860-6kz0iws6 92 3 for for IN cord-293860-6kz0iws6 92 4 the the DT cord-293860-6kz0iws6 92 5 care care NN cord-293860-6kz0iws6 92 6 of of IN cord-293860-6kz0iws6 92 7 hospitalised hospitalise VBN cord-293860-6kz0iws6 92 8 patients patient NNS cord-293860-6kz0iws6 92 9 to to TO cord-293860-6kz0iws6 92 10 be be VB cord-293860-6kz0iws6 92 11 escalated escalate VBN cord-293860-6kz0iws6 92 12 up up RP cord-293860-6kz0iws6 92 13 to to TO cord-293860-6kz0iws6 92 14 level level VB cord-293860-6kz0iws6 92 15 3 3 CD cord-293860-6kz0iws6 92 16 critical critical JJ cord-293860-6kz0iws6 92 17 care care NN cord-293860-6kz0iws6 92 18 . . . cord-293860-6kz0iws6 93 1 It -PRON- PRP cord-293860-6kz0iws6 93 2 may may MD cord-293860-6kz0iws6 93 3 shorten shorten VB cord-293860-6kz0iws6 93 4 the the DT cord-293860-6kz0iws6 93 5 course course NN cord-293860-6kz0iws6 93 6 of of IN cord-293860-6kz0iws6 93 7 mild mild JJ cord-293860-6kz0iws6 93 8 to to TO cord-293860-6kz0iws6 93 9 moderate moderate JJ cord-293860-6kz0iws6 93 10 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 93 11 with with IN cord-293860-6kz0iws6 93 12 the the DT cord-293860-6kz0iws6 93 13 attendant attendant JJ cord-293860-6kz0iws6 93 14 social social JJ cord-293860-6kz0iws6 93 15 , , , cord-293860-6kz0iws6 93 16 economic economic JJ cord-293860-6kz0iws6 93 17 and and CC cord-293860-6kz0iws6 93 18 healthcare healthcare NN cord-293860-6kz0iws6 93 19 system system NN cord-293860-6kz0iws6 93 20 benefits benefit NNS cord-293860-6kz0iws6 93 21 that that WDT cord-293860-6kz0iws6 93 22 would would MD cord-293860-6kz0iws6 93 23 bring bring VB cord-293860-6kz0iws6 93 24 . . . cord-293860-6kz0iws6 94 1 Furthermore furthermore RB cord-293860-6kz0iws6 94 2 , , , cord-293860-6kz0iws6 94 3 it -PRON- PRP cord-293860-6kz0iws6 94 4 has have VBZ cord-293860-6kz0iws6 94 5 a a DT cord-293860-6kz0iws6 94 6 good good JJ cord-293860-6kz0iws6 94 7 safety safety NN cord-293860-6kz0iws6 94 8 profile profile NN cord-293860-6kz0iws6 94 9 . . . cord-293860-6kz0iws6 95 1 But but CC cord-293860-6kz0iws6 95 2 perhaps perhaps RB cord-293860-6kz0iws6 95 3 most most RBS cord-293860-6kz0iws6 95 4 importantly importantly RB cord-293860-6kz0iws6 95 5 , , , cord-293860-6kz0iws6 95 6 if if IN cord-293860-6kz0iws6 95 7 montelukast montelukast NNP cord-293860-6kz0iws6 95 8 was be VBD cord-293860-6kz0iws6 95 9 shown show VBN cord-293860-6kz0iws6 95 10 to to TO cord-293860-6kz0iws6 95 11 be be VB cord-293860-6kz0iws6 95 12 of of IN cord-293860-6kz0iws6 95 13 clinical clinical JJ cord-293860-6kz0iws6 95 14 benefit benefit NN cord-293860-6kz0iws6 95 15 in in IN cord-293860-6kz0iws6 95 16 well well RB cord-293860-6kz0iws6 95 17 - - HYPH cord-293860-6kz0iws6 95 18 conducted conduct VBN cord-293860-6kz0iws6 95 19 studies study NNS cord-293860-6kz0iws6 95 20 it -PRON- PRP cord-293860-6kz0iws6 95 21 is be VBZ cord-293860-6kz0iws6 95 22 a a DT cord-293860-6kz0iws6 95 23 widely widely RB cord-293860-6kz0iws6 95 24 applicable applicable JJ cord-293860-6kz0iws6 95 25 treatment treatment NN cord-293860-6kz0iws6 95 26 , , , cord-293860-6kz0iws6 95 27 accessible accessible JJ cord-293860-6kz0iws6 95 28 to to IN cord-293860-6kz0iws6 95 29 all all DT cord-293860-6kz0iws6 95 30 patients patient NNS cord-293860-6kz0iws6 95 31 , , , cord-293860-6kz0iws6 95 32 and and CC cord-293860-6kz0iws6 95 33 at at IN cord-293860-6kz0iws6 95 34 just just RB cord-293860-6kz0iws6 95 35 over over RB cord-293860-6kz0iws6 95 36 £ £ $ cord-293860-6kz0iws6 95 37 4 4 CD cord-293860-6kz0iws6 95 38 per per IN cord-293860-6kz0iws6 95 39 month month NN cord-293860-6kz0iws6 95 40 21 21 CD cord-293860-6kz0iws6 95 41 , , , cord-293860-6kz0iws6 95 42 not not RB cord-293860-6kz0iws6 95 43 just just RB cord-293860-6kz0iws6 95 44 available available JJ cord-293860-6kz0iws6 95 45 to to IN cord-293860-6kz0iws6 95 46 those those DT cord-293860-6kz0iws6 95 47 who who WP cord-293860-6kz0iws6 95 48 live live VBP cord-293860-6kz0iws6 95 49 in in IN cord-293860-6kz0iws6 95 50 nations nation NNS cord-293860-6kz0iws6 95 51 with with IN cord-293860-6kz0iws6 95 52 firstworld firstworld NNP cord-293860-6kz0iws6 95 53 healthcare healthcare NN cord-293860-6kz0iws6 95 54 resources resource NNS cord-293860-6kz0iws6 95 55 that that WDT cord-293860-6kz0iws6 95 56 can can MD cord-293860-6kz0iws6 95 57 afford afford VB cord-293860-6kz0iws6 95 58 highly highly RB cord-293860-6kz0iws6 95 59 expensive expensive JJ cord-293860-6kz0iws6 95 60 new new JJ cord-293860-6kz0iws6 95 61 drugs drug NNS cord-293860-6kz0iws6 95 62 . . . cord-293860-6kz0iws6 96 1 Neither neither DT cord-293860-6kz0iws6 96 2 of of IN cord-293860-6kz0iws6 96 3 the the DT cord-293860-6kz0iws6 96 4 authors author NNS cord-293860-6kz0iws6 96 5 have have VBP cord-293860-6kz0iws6 96 6 any any DT cord-293860-6kz0iws6 96 7 conflicting conflict VBG cord-293860-6kz0iws6 96 8 interests interest NNS cord-293860-6kz0iws6 96 9 and and CC cord-293860-6kz0iws6 96 10 neither neither CC cord-293860-6kz0iws6 96 11 receive receive VBP cord-293860-6kz0iws6 96 12 funding funding NN cord-293860-6kz0iws6 96 13 from from IN cord-293860-6kz0iws6 96 14 any any DT cord-293860-6kz0iws6 96 15 third third JJ cord-293860-6kz0iws6 96 16 party party NN cord-293860-6kz0iws6 96 17 or or CC cord-293860-6kz0iws6 96 18 external external JJ cord-293860-6kz0iws6 96 19 source source NN cord-293860-6kz0iws6 96 20 . . . cord-293860-6kz0iws6 97 1 Professor Professor NNP cord-293860-6kz0iws6 97 2 Kerrigan Kerrigan NNP cord-293860-6kz0iws6 97 3 was be VBD cord-293860-6kz0iws6 97 4 the the DT cord-293860-6kz0iws6 97 5 original original JJ cord-293860-6kz0iws6 97 6 creator creator NN cord-293860-6kz0iws6 97 7 of of IN cord-293860-6kz0iws6 97 8 the the DT cord-293860-6kz0iws6 97 9 hypothesis hypothesis NN cord-293860-6kz0iws6 97 10 linking link VBG cord-293860-6kz0iws6 97 11 potential potential JJ cord-293860-6kz0iws6 97 12 therapeutic therapeutic JJ cord-293860-6kz0iws6 97 13 benefits benefit NNS cord-293860-6kz0iws6 97 14 of of IN cord-293860-6kz0iws6 97 15 montelukast montelukast NNP cord-293860-6kz0iws6 97 16 in in IN cord-293860-6kz0iws6 97 17 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 97 18 , , , cord-293860-6kz0iws6 97 19 with with IN cord-293860-6kz0iws6 97 20 the the DT cord-293860-6kz0iws6 97 21 inflammatory inflammatory JJ cord-293860-6kz0iws6 97 22 state state NN cord-293860-6kz0iws6 97 23 associated associate VBN cord-293860-6kz0iws6 97 24 with with IN cord-293860-6kz0iws6 97 25 obesity obesity NN cord-293860-6kz0iws6 97 26 . . . cord-293860-6kz0iws6 98 1 Both both DT cord-293860-6kz0iws6 98 2 authors author NNS cord-293860-6kz0iws6 98 3 were be VBD cord-293860-6kz0iws6 98 4 involved involve VBN cord-293860-6kz0iws6 98 5 in in IN cord-293860-6kz0iws6 98 6 background background NN cord-293860-6kz0iws6 98 7 research research NN cord-293860-6kz0iws6 98 8 and and CC cord-293860-6kz0iws6 98 9 the the DT cord-293860-6kz0iws6 98 10 writing writing NN cord-293860-6kz0iws6 98 11 of of IN cord-293860-6kz0iws6 98 12 the the DT cord-293860-6kz0iws6 98 13 manuscript manuscript NN cord-293860-6kz0iws6 98 14 . . . cord-293860-6kz0iws6 99 1 This this DT cord-293860-6kz0iws6 99 2 paper paper NN cord-293860-6kz0iws6 99 3 did do VBD cord-293860-6kz0iws6 99 4 not not RB cord-293860-6kz0iws6 99 5 require require VB cord-293860-6kz0iws6 99 6 ethics ethic NNS cord-293860-6kz0iws6 99 7 approval approval NN cord-293860-6kz0iws6 99 8 . . . cord-293860-6kz0iws6 100 1 Regulation regulation NN cord-293860-6kz0iws6 100 2 of of IN cord-293860-6kz0iws6 100 3 adipose adipose JJ cord-293860-6kz0iws6 100 4 tissue tissue NN cord-293860-6kz0iws6 100 5 inflammation inflammation NN cord-293860-6kz0iws6 100 6 by by IN cord-293860-6kz0iws6 100 7 interleukin interleukin NN cord-293860-6kz0iws6 100 8 6 6 CD cord-293860-6kz0iws6 100 9 Circulating circulate VBG cord-293860-6kz0iws6 100 10 levels level NNS cord-293860-6kz0iws6 100 11 of of IN cord-293860-6kz0iws6 100 12 MCP-1 MCP-1 NNP cord-293860-6kz0iws6 101 1 and and CC cord-293860-6kz0iws6 101 2 IL-8 IL-8 NNP cord-293860-6kz0iws6 101 3 are be VBP cord-293860-6kz0iws6 101 4 elevated elevate VBN cord-293860-6kz0iws6 101 5 in in IN cord-293860-6kz0iws6 101 6 human human JJ cord-293860-6kz0iws6 101 7 obese obese JJ cord-293860-6kz0iws6 101 8 subjects subject NNS cord-293860-6kz0iws6 101 9 and and CC cord-293860-6kz0iws6 101 10 associated associate VBN cord-293860-6kz0iws6 101 11 with with IN cord-293860-6kz0iws6 101 12 obesity obesity NN cord-293860-6kz0iws6 101 13 - - HYPH cord-293860-6kz0iws6 101 14 related relate VBN cord-293860-6kz0iws6 101 15 parameters parameter NNS cord-293860-6kz0iws6 101 16 Inflammatory inflammatory JJ cord-293860-6kz0iws6 101 17 cytokines cytokine NNS cord-293860-6kz0iws6 101 18 in in IN cord-293860-6kz0iws6 101 19 general general JJ cord-293860-6kz0iws6 101 20 and and CC cord-293860-6kz0iws6 101 21 central central JJ cord-293860-6kz0iws6 101 22 obesity obesity NN cord-293860-6kz0iws6 101 23 and and CC cord-293860-6kz0iws6 101 24 modulating modulate VBG cord-293860-6kz0iws6 101 25 effects effect NNS cord-293860-6kz0iws6 101 26 of of IN cord-293860-6kz0iws6 101 27 physical physical JJ cord-293860-6kz0iws6 101 28 activity activity NN cord-293860-6kz0iws6 101 29 Features feature NNS cord-293860-6kz0iws6 101 30 of of IN cord-293860-6kz0iws6 101 31 16,749 16,749 CD cord-293860-6kz0iws6 101 32 hospitalised hospitalise VBN cord-293860-6kz0iws6 101 33 UK UK NNP cord-293860-6kz0iws6 101 34 patients patient NNS cord-293860-6kz0iws6 101 35 with with IN cord-293860-6kz0iws6 101 36 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 101 37 using use VBG cord-293860-6kz0iws6 101 38 the the DT cord-293860-6kz0iws6 101 39 ISARIC ISARIC NNP cord-293860-6kz0iws6 102 1 WHO who WP cord-293860-6kz0iws6 102 2 Clinical Clinical NNP cord-293860-6kz0iws6 102 3 Characterisation Characterisation NNP cord-293860-6kz0iws6 102 4 Protocol Protocol NNP cord-293860-6kz0iws6 102 5 Are be VBP cord-293860-6kz0iws6 102 6 more more RBR cord-293860-6kz0iws6 102 7 black black JJ cord-293860-6kz0iws6 102 8 , , , cord-293860-6kz0iws6 102 9 Asian asian JJ cord-293860-6kz0iws6 102 10 and and CC cord-293860-6kz0iws6 102 11 minority minority NN cord-293860-6kz0iws6 102 12 ethnic ethnic JJ cord-293860-6kz0iws6 102 13 people people NNS cord-293860-6kz0iws6 102 14 dying die VBG cord-293860-6kz0iws6 102 15 with with IN cord-293860-6kz0iws6 102 16 Covid-19 covid-19 NN cord-293860-6kz0iws6 102 17 than than IN cord-293860-6kz0iws6 102 18 might may MD cord-293860-6kz0iws6 102 19 be be VB cord-293860-6kz0iws6 102 20 expected expect VBN cord-293860-6kz0iws6 102 21 ? ? . cord-293860-6kz0iws6 103 1 Southall Southall NNP cord-293860-6kz0iws6 103 2 And and CC cord-293860-6kz0iws6 103 3 Brent Brent NNP cord-293860-6kz0iws6 103 4 REvisited REvisited NNP cord-293860-6kz0iws6 103 5 : : : cord-293860-6kz0iws6 104 1 Cohort cohort NN cord-293860-6kz0iws6 104 2 profile profile NN cord-293860-6kz0iws6 104 3 of of IN cord-293860-6kz0iws6 104 4 SABRE SABRE NNP cord-293860-6kz0iws6 104 5 , , , cord-293860-6kz0iws6 104 6 a a DT cord-293860-6kz0iws6 104 7 UK UK NNP cord-293860-6kz0iws6 104 8 population population NN cord-293860-6kz0iws6 104 9 - - HYPH cord-293860-6kz0iws6 104 10 based base VBN cord-293860-6kz0iws6 104 11 comparison comparison NN cord-293860-6kz0iws6 104 12 of of IN cord-293860-6kz0iws6 104 13 cardiovascular cardiovascular JJ cord-293860-6kz0iws6 104 14 disease disease NN cord-293860-6kz0iws6 104 15 and and CC cord-293860-6kz0iws6 104 16 diabetes diabetes NN cord-293860-6kz0iws6 104 17 in in IN cord-293860-6kz0iws6 104 18 people people NNS cord-293860-6kz0iws6 104 19 of of IN cord-293860-6kz0iws6 104 20 European european JJ cord-293860-6kz0iws6 104 21 , , , cord-293860-6kz0iws6 104 22 Indian indian JJ cord-293860-6kz0iws6 104 23 Asian asian JJ cord-293860-6kz0iws6 104 24 and and CC cord-293860-6kz0iws6 104 25 African african JJ cord-293860-6kz0iws6 104 26 Caribbean caribbean JJ cord-293860-6kz0iws6 104 27 origins origin NNS cord-293860-6kz0iws6 105 1 Is be VBZ cord-293860-6kz0iws6 105 2 ethnicity ethnicity NN cord-293860-6kz0iws6 105 3 linked link VBN cord-293860-6kz0iws6 105 4 to to IN cord-293860-6kz0iws6 105 5 incidence incidence NN cord-293860-6kz0iws6 105 6 or or CC cord-293860-6kz0iws6 105 7 outcomes outcome NNS cord-293860-6kz0iws6 105 8 of of IN cord-293860-6kz0iws6 105 9 covid-19 covid-19 NN cord-293860-6kz0iws6 105 10 ? ? . cord-293860-6kz0iws6 106 1 Montelukast Montelukast NNP cord-293860-6kz0iws6 106 2 , , , cord-293860-6kz0iws6 106 3 a a DT cord-293860-6kz0iws6 106 4 leukotriene leukotriene NN cord-293860-6kz0iws6 106 5 receptor receptor NN cord-293860-6kz0iws6 106 6 antagonist antagonist NN cord-293860-6kz0iws6 106 7 , , , cord-293860-6kz0iws6 106 8 inhibits inhibit VBZ cord-293860-6kz0iws6 106 9 the the DT cord-293860-6kz0iws6 106 10 late late JJ cord-293860-6kz0iws6 106 11 airway airway NN cord-293860-6kz0iws6 106 12 response response NN cord-293860-6kz0iws6 106 13 to to IN cord-293860-6kz0iws6 106 14 antigen antigen NN cord-293860-6kz0iws6 106 15 , , , cord-293860-6kz0iws6 106 16 airway airway NN cord-293860-6kz0iws6 106 17 eosinophilia eosinophilia NN cord-293860-6kz0iws6 106 18 , , , cord-293860-6kz0iws6 106 19 and and CC cord-293860-6kz0iws6 106 20 IL-5-expressing il-5-expressing NN cord-293860-6kz0iws6 106 21 cells cell NNS cord-293860-6kz0iws6 106 22 in in IN cord-293860-6kz0iws6 106 23 Brown Brown NNP cord-293860-6kz0iws6 106 24 Norway Norway NNP cord-293860-6kz0iws6 106 25 rats rat NNS cord-293860-6kz0iws6 106 26 Effect Effect NNP cord-293860-6kz0iws6 106 27 of of IN cord-293860-6kz0iws6 106 28 Montelukast Montelukast NNP cord-293860-6kz0iws6 106 29 on on IN cord-293860-6kz0iws6 106 30 Pro pro JJ cord-293860-6kz0iws6 106 31 - - JJ cord-293860-6kz0iws6 106 32 inflammatory inflammatory JJ cord-293860-6kz0iws6 106 33 Cytokine cytokine NN cord-293860-6kz0iws6 106 34 Production production NN cord-293860-6kz0iws6 106 35 During during IN cord-293860-6kz0iws6 106 36 Naturally naturally RB cord-293860-6kz0iws6 106 37 Acquired acquire VBN cord-293860-6kz0iws6 106 38 Viral Viral NNP cord-293860-6kz0iws6 106 39 Upper Upper NNP cord-293860-6kz0iws6 106 40 Respiratory respiratory JJ cord-293860-6kz0iws6 106 41 Infections infection NNS cord-293860-6kz0iws6 106 42 ( ( -LRB- cord-293860-6kz0iws6 106 43 vURIs vuris NN cord-293860-6kz0iws6 106 44 ) ) -RRB- cord-293860-6kz0iws6 107 1 in in IN cord-293860-6kz0iws6 107 2 Adults Adults NNP cord-293860-6kz0iws6 107 3 Analysis Analysis NNP cord-293860-6kz0iws6 107 4 of of IN cord-293860-6kz0iws6 107 5 therapeutic therapeutic JJ cord-293860-6kz0iws6 107 6 targets target NNS cord-293860-6kz0iws6 107 7 for for IN cord-293860-6kz0iws6 107 8 SARS SARS NNP cord-293860-6kz0iws6 107 9 - - HYPH cord-293860-6kz0iws6 107 10 CoV-2 CoV-2 NNP cord-293860-6kz0iws6 107 11 and and CC cord-293860-6kz0iws6 107 12 discovery discovery NN cord-293860-6kz0iws6 107 13 of of IN cord-293860-6kz0iws6 107 14 potential potential JJ cord-293860-6kz0iws6 107 15 drugs drug NNS cord-293860-6kz0iws6 107 16 by by IN cord-293860-6kz0iws6 107 17 computational computational JJ cord-293860-6kz0iws6 107 18 methods method NNS cord-293860-6kz0iws6 107 19 Identification identification NN cord-293860-6kz0iws6 107 20 of of IN cord-293860-6kz0iws6 107 21 FDA FDA NNP cord-293860-6kz0iws6 107 22 approved approve VBD cord-293860-6kz0iws6 107 23 drugs drug NNS cord-293860-6kz0iws6 107 24 targeting target VBG cord-293860-6kz0iws6 107 25 COVID-19 covid-19 JJ cord-293860-6kz0iws6 107 26 virus virus NN cord-293860-6kz0iws6 107 27 by by IN cord-293860-6kz0iws6 107 28 structure structure NN cord-293860-6kz0iws6 107 29 - - HYPH cord-293860-6kz0iws6 107 30 based base VBN cord-293860-6kz0iws6 107 31 drug drug NN cord-293860-6kz0iws6 107 32 repositioning repositioning NN cord-293860-6kz0iws6 107 33 ( ( -LRB- cord-293860-6kz0iws6 107 34 Pre pre JJ cord-293860-6kz0iws6 107 35 - - JJ cord-293860-6kz0iws6 107 36 print print JJ cord-293860-6kz0iws6 107 37 ) ) -RRB- cord-293860-6kz0iws6 107 38 Dysregulation dysregulation NN cord-293860-6kz0iws6 107 39 of of IN cord-293860-6kz0iws6 107 40 immune immune JJ cord-293860-6kz0iws6 107 41 response response NN cord-293860-6kz0iws6 107 42 in in IN cord-293860-6kz0iws6 107 43 patients patient NNS cord-293860-6kz0iws6 107 44 with with IN cord-293860-6kz0iws6 107 45 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 107 46 in in IN cord-293860-6kz0iws6 107 47 Wuhan Wuhan NNP cord-293860-6kz0iws6 107 48 , , , cord-293860-6kz0iws6 107 49 China China NNP cord-293860-6kz0iws6 107 50 . . . cord-293860-6kz0iws6 108 1 Clin Clin NNP cord-293860-6kz0iws6 108 2 Infect infect NN cord-293860-6kz0iws6 108 3 Dis Dis NNP cord-293860-6kz0iws6 108 4 Clinical clinical JJ cord-293860-6kz0iws6 108 5 features feature NNS cord-293860-6kz0iws6 108 6 of of IN cord-293860-6kz0iws6 108 7 patients patient NNS cord-293860-6kz0iws6 108 8 infected infect VBN cord-293860-6kz0iws6 108 9 with with IN cord-293860-6kz0iws6 108 10 2019 2019 CD cord-293860-6kz0iws6 108 11 novel novel JJ cord-293860-6kz0iws6 108 12 coronavirus coronavirus NN cord-293860-6kz0iws6 108 13 in in IN cord-293860-6kz0iws6 108 14 Wuhan Wuhan NNP cord-293860-6kz0iws6 108 15 Clinical Clinical NNP cord-293860-6kz0iws6 108 16 Features Features NNPS cord-293860-6kz0iws6 108 17 of of IN cord-293860-6kz0iws6 108 18 69 69 CD cord-293860-6kz0iws6 108 19 Cases case NNS cord-293860-6kz0iws6 108 20 with with IN cord-293860-6kz0iws6 108 21 Coronavirus Coronavirus NNP cord-293860-6kz0iws6 108 22 Disease Disease NNP cord-293860-6kz0iws6 108 23 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 108 24 : : : cord-293860-6kz0iws6 108 25 consider consider VB cord-293860-6kz0iws6 108 26 cytokine cytokine JJ cord-293860-6kz0iws6 108 27 storm storm NN cord-293860-6kz0iws6 108 28 syndromes syndrome NNS cord-293860-6kz0iws6 108 29 and and CC cord-293860-6kz0iws6 108 30 immunosuppression immunosuppression NN cord-293860-6kz0iws6 108 31 Pathogenic pathogenic JJ cord-293860-6kz0iws6 108 32 human human JJ cord-293860-6kz0iws6 108 33 coronavirus coronavirus NN cord-293860-6kz0iws6 108 34 infections infection NNS cord-293860-6kz0iws6 108 35 : : : cord-293860-6kz0iws6 108 36 causes cause NNS cord-293860-6kz0iws6 108 37 and and CC cord-293860-6kz0iws6 108 38 consequences consequence NNS cord-293860-6kz0iws6 108 39 of of IN cord-293860-6kz0iws6 108 40 cytokine cytokine NN cord-293860-6kz0iws6 108 41 storm storm NN cord-293860-6kz0iws6 108 42 and and CC cord-293860-6kz0iws6 108 43 immunopathology immunopathology NN cord-293860-6kz0iws6 108 44 Cysteinyl Cysteinyl NNP cord-293860-6kz0iws6 108 45 leukotrienes leukotriene NNS cord-293860-6kz0iws6 108 46 and and CC cord-293860-6kz0iws6 108 47 their -PRON- PRP$ cord-293860-6kz0iws6 108 48 receptors receptor NNS cord-293860-6kz0iws6 108 49 : : : cord-293860-6kz0iws6 108 50 cellular cellular JJ cord-293860-6kz0iws6 108 51 distribution distribution NN cord-293860-6kz0iws6 108 52 and and CC cord-293860-6kz0iws6 108 53 function function NN cord-293860-6kz0iws6 108 54 in in IN cord-293860-6kz0iws6 108 55 immune immune JJ cord-293860-6kz0iws6 108 56 and and CC cord-293860-6kz0iws6 108 57 inflammatory inflammatory JJ cord-293860-6kz0iws6 108 58 responses response NNS cord-293860-6kz0iws6 108 59 Cysteinyl Cysteinyl NNP cord-293860-6kz0iws6 108 60 leukotrienes leukotriene NNS cord-293860-6kz0iws6 108 61 : : : cord-293860-6kz0iws6 108 62 multifunctional multifunctional JJ cord-293860-6kz0iws6 108 63 mediators mediator NNS cord-293860-6kz0iws6 108 64 in in IN cord-293860-6kz0iws6 108 65 allergic allergic JJ cord-293860-6kz0iws6 108 66 rhinitis rhinitis NN cord-293860-6kz0iws6 108 67 Leukotriene Leukotriene NNP cord-293860-6kz0iws6 108 68 E4 E4 NNP cord-293860-6kz0iws6 108 69 and and CC cord-293860-6kz0iws6 108 70 granulocytic granulocytic JJ cord-293860-6kz0iws6 108 71 infiltration infiltration NN cord-293860-6kz0iws6 108 72 into into IN cord-293860-6kz0iws6 108 73 asthmatic asthmatic JJ cord-293860-6kz0iws6 108 74 airways airway NNS cord-293860-6kz0iws6 108 75 Singulair Singulair NNP cord-293860-6kz0iws6 108 76 ( ( -LRB- cord-293860-6kz0iws6 108 77 montelukast montelukast NNP cord-293860-6kz0iws6 108 78 sodium sodium NN cord-293860-6kz0iws6 108 79 ) ) -RRB- cord-293860-6kz0iws6 109 1 US US NNP cord-293860-6kz0iws6 109 2 FDA FDA NNP cord-293860-6kz0iws6 109 3 Label Label NNP cord-293860-6kz0iws6 109 4 Coronaviruses Coronaviruses NNP cord-293860-6kz0iws6 109 5 -drug -drug NNP cord-293860-6kz0iws6 109 6 discovery discovery NN cord-293860-6kz0iws6 109 7 and and CC cord-293860-6kz0iws6 109 8 therapeutic therapeutic JJ cord-293860-6kz0iws6 109 9 options option NNS cord-293860-6kz0iws6 110 1 Structural structural JJ cord-293860-6kz0iws6 110 2 insights insight NNS cord-293860-6kz0iws6 110 3 into into IN cord-293860-6kz0iws6 110 4 coronavirus coronavirus NN cord-293860-6kz0iws6 110 5 entry entry NN cord-293860-6kz0iws6 110 6 A a DT cord-293860-6kz0iws6 110 7 pneumonia pneumonia NN cord-293860-6kz0iws6 110 8 outbreak outbreak NN cord-293860-6kz0iws6 110 9 associated associate VBN cord-293860-6kz0iws6 110 10 with with IN cord-293860-6kz0iws6 110 11 a a DT cord-293860-6kz0iws6 110 12 new new JJ cord-293860-6kz0iws6 110 13 coronavirus coronavirus NN cord-293860-6kz0iws6 110 14 of of IN cord-293860-6kz0iws6 110 15 probable probable JJ cord-293860-6kz0iws6 110 16 bat bat NN cord-293860-6kz0iws6 110 17 origin origin NN cord-293860-6kz0iws6 110 18 Structure structure NN cord-293860-6kz0iws6 110 19 , , , cord-293860-6kz0iws6 110 20 Function Function NNP cord-293860-6kz0iws6 110 21 , , , cord-293860-6kz0iws6 110 22 and and CC cord-293860-6kz0iws6 110 23 Antigenicity Antigenicity NNP cord-293860-6kz0iws6 110 24 of of IN cord-293860-6kz0iws6 110 25 the the DT cord-293860-6kz0iws6 110 26 SARS SARS NNP cord-293860-6kz0iws6 110 27 - - HYPH cord-293860-6kz0iws6 110 28 CoV-2 CoV-2 NNP cord-293860-6kz0iws6 110 29 Spike Spike NNP cord-293860-6kz0iws6 110 30 Glycoprotein Glycoprotein NNP cord-293860-6kz0iws6 110 31 ZINC zinc NN cord-293860-6kz0iws6 110 32 : : : cord-293860-6kz0iws6 110 33 a a DT cord-293860-6kz0iws6 110 34 free free JJ cord-293860-6kz0iws6 110 35 tool tool NN cord-293860-6kz0iws6 110 36 to to TO cord-293860-6kz0iws6 110 37 discover discover VB cord-293860-6kz0iws6 110 38 chemistry chemistry NN cord-293860-6kz0iws6 110 39 for for IN cord-293860-6kz0iws6 110 40 biology biology NN cord-293860-6kz0iws6 111 1 A a DT cord-293860-6kz0iws6 111 2 real real JJ cord-293860-6kz0iws6 111 3 - - HYPH cord-293860-6kz0iws6 111 4 time time NN cord-293860-6kz0iws6 111 5 dashboard dashboard NN cord-293860-6kz0iws6 111 6 of of IN cord-293860-6kz0iws6 111 7 clinical clinical JJ cord-293860-6kz0iws6 111 8 trials trial NNS cord-293860-6kz0iws6 111 9 for for IN cord-293860-6kz0iws6 111 10 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 111 11 Clinical clinical JJ cord-293860-6kz0iws6 111 12 evidence evidence NN cord-293860-6kz0iws6 111 13 does do VBZ cord-293860-6kz0iws6 111 14 not not RB cord-293860-6kz0iws6 111 15 support support VB cord-293860-6kz0iws6 111 16 corticosteroid corticosteroid NN cord-293860-6kz0iws6 111 17 treatment treatment NN cord-293860-6kz0iws6 111 18 for for IN cord-293860-6kz0iws6 111 19 2019-nCoV 2019-ncov CD cord-293860-6kz0iws6 111 20 lung lung NN cord-293860-6kz0iws6 111 21 injury injury NN cord-293860-6kz0iws6 111 22 Immunosuppression Immunosuppression NNP cord-293860-6kz0iws6 111 23 for for IN cord-293860-6kz0iws6 111 24 hyperinflammation hyperinflammation NN cord-293860-6kz0iws6 111 25 in in IN cord-293860-6kz0iws6 111 26 COVID-19 COVID-19 NNP cord-293860-6kz0iws6 111 27 : : : cord-293860-6kz0iws6 111 28 a a DT cord-293860-6kz0iws6 111 29 double double RB cord-293860-6kz0iws6 111 30 - - HYPH cord-293860-6kz0iws6 111 31 edged edged JJ cord-293860-6kz0iws6 111 32 sword sword NN cord-293860-6kz0iws6 111 33 ? ? . cord-293860-6kz0iws6 112 1 Can Can MD cord-293860-6kz0iws6 112 2 we -PRON- PRP cord-293860-6kz0iws6 112 3 use use VB cord-293860-6kz0iws6 112 4 interleukin-6 interleukin-6 NNP cord-293860-6kz0iws6 112 5 ( ( -LRB- cord-293860-6kz0iws6 112 6 IL-6 IL-6 NNP cord-293860-6kz0iws6 112 7 ) ) -RRB- cord-293860-6kz0iws6 112 8 blockade blockade NN cord-293860-6kz0iws6 112 9 for for IN cord-293860-6kz0iws6 112 10 coronavirus coronavirus NN cord-293860-6kz0iws6 112 11 disease disease NN cord-293860-6kz0iws6 112 12 2019 2019 CD cord-293860-6kz0iws6 112 13 ( ( -LRB- cord-293860-6kz0iws6 112 14 COVID-19)-induced covid-19)-induce VBN cord-293860-6kz0iws6 112 15 cytokine cytokine NN cord-293860-6kz0iws6 112 16 release release NN cord-293860-6kz0iws6 112 17 syndrome syndrome NN cord-293860-6kz0iws6 112 18 ( ( -LRB- cord-293860-6kz0iws6 112 19 CRS CRS NNP cord-293860-6kz0iws6 112 20 ) ) -RRB- cord-293860-6kz0iws6 112 21 ? ? . cord-293860-6kz0iws6 113 1 Why why WRB cord-293860-6kz0iws6 113 2 tocilizumab tocilizumab NN cord-293860-6kz0iws6 113 3 could could MD cord-293860-6kz0iws6 113 4 be be VB cord-293860-6kz0iws6 113 5 an an DT cord-293860-6kz0iws6 113 6 effective effective JJ cord-293860-6kz0iws6 113 7 treatment treatment NN cord-293860-6kz0iws6 113 8 for for IN cord-293860-6kz0iws6 113 9 severe severe JJ cord-293860-6kz0iws6 113 10 COVID-19 covid-19 NN cord-293860-6kz0iws6 113 11 ? ? .