id sid tid token lemma pos cord-274510-fo7p98np 1 1 key key JJ cord-274510-fo7p98np 2 1 : : : cord-274510-fo7p98np 2 2 cord-274510-fo7p98np cord-274510-fo7p98np NNP cord-274510-fo7p98np 2 3 authors author NNS cord-274510-fo7p98np 2 4 : : : cord-274510-fo7p98np 2 5 Spadera Spadera NNP cord-274510-fo7p98np 2 6 , , , cord-274510-fo7p98np 2 7 Lucrezia Lucrezia NNP cord-274510-fo7p98np 2 8 ; ; : cord-274510-fo7p98np 2 9 Spadera Spadera NNP cord-274510-fo7p98np 2 10 , , , cord-274510-fo7p98np 2 11 Maria Maria NNP cord-274510-fo7p98np 2 12 title title NN cord-274510-fo7p98np 2 13 : : : cord-274510-fo7p98np 2 14 Potential potential JJ cord-274510-fo7p98np 2 15 Role role NN cord-274510-fo7p98np 2 16 of of IN cord-274510-fo7p98np 2 17 GcMAF GcMAF NNPS cord-274510-fo7p98np 2 18 in in IN cord-274510-fo7p98np 2 19 suppressing suppress VBG cord-274510-fo7p98np 2 20 the the DT cord-274510-fo7p98np 2 21 severity severity NN cord-274510-fo7p98np 2 22 of of IN cord-274510-fo7p98np 2 23 COVID-19-induced COVID-19-induced NNP cord-274510-fo7p98np 2 24 immune immune JJ cord-274510-fo7p98np 2 25 responses response NNS cord-274510-fo7p98np 2 26 : : : cord-274510-fo7p98np 2 27 lesson lesson NN cord-274510-fo7p98np 2 28 learned learn VBN cord-274510-fo7p98np 2 29 from from IN cord-274510-fo7p98np 2 30 HIV HIV NNP cord-274510-fo7p98np 2 31 date date NN cord-274510-fo7p98np 2 32 : : : cord-274510-fo7p98np 2 33 2020 2020 CD cord-274510-fo7p98np 2 34 - - HYPH cord-274510-fo7p98np 2 35 09 09 CD cord-274510-fo7p98np 2 36 - - HYPH cord-274510-fo7p98np 2 37 24 24 CD cord-274510-fo7p98np 2 38 journal journal NN cord-274510-fo7p98np 2 39 : : : cord-274510-fo7p98np 3 1 Med Med NNP cord-274510-fo7p98np 3 2 Hypotheses Hypotheses NNP cord-274510-fo7p98np 3 3 DOI DOI NNP cord-274510-fo7p98np 3 4 : : : cord-274510-fo7p98np 4 1 10.1016 10.1016 CD cord-274510-fo7p98np 4 2 / / SYM cord-274510-fo7p98np 4 3 j.mehy.2020.110293 j.mehy.2020.110293 NNP cord-274510-fo7p98np 4 4 sha sha NNP cord-274510-fo7p98np 4 5 : : : cord-274510-fo7p98np 4 6 263ebe834be67a36918a1a6bc87803947a681d54 263ebe834be67a36918a1a6bc87803947a681d54 CD cord-274510-fo7p98np 5 1 doc_id doc_id CD cord-274510-fo7p98np 5 2 : : : cord-274510-fo7p98np 5 3 274510 274510 CD cord-274510-fo7p98np 5 4 cord_uid cord_uid NNS cord-274510-fo7p98np 5 5 : : : cord-274510-fo7p98np 6 1 fo7p98np fo7p98np NNP cord-274510-fo7p98np 6 2 nan nan NNP cord-274510-fo7p98np 7 1 Over over IN cord-274510-fo7p98np 7 2 the the DT cord-274510-fo7p98np 7 3 last last JJ cord-274510-fo7p98np 7 4 six six CD cord-274510-fo7p98np 7 5 months month NNS cord-274510-fo7p98np 7 6 , , , cord-274510-fo7p98np 7 7 there there EX cord-274510-fo7p98np 7 8 have have VBP cord-274510-fo7p98np 7 9 been be VBN cord-274510-fo7p98np 7 10 increasing increase VBG cord-274510-fo7p98np 7 11 numbers number NNS cord-274510-fo7p98np 7 12 of of IN cord-274510-fo7p98np 7 13 reports report NNS cord-274510-fo7p98np 7 14 that that WDT cord-274510-fo7p98np 7 15 struggle struggle VBP cord-274510-fo7p98np 7 16 to to TO cord-274510-fo7p98np 7 17 understand understand VB cord-274510-fo7p98np 7 18 the the DT cord-274510-fo7p98np 7 19 pathogenesis pathogenesis NN cord-274510-fo7p98np 7 20 of of IN cord-274510-fo7p98np 7 21 the the DT cord-274510-fo7p98np 7 22 coronavirus coronavirus NN cord-274510-fo7p98np 7 23 disease disease NN cord-274510-fo7p98np 7 24 2019 2019 CD cord-274510-fo7p98np 7 25 ( ( -LRB- cord-274510-fo7p98np 7 26 COVID- COVID- NNP cord-274510-fo7p98np 7 27 19 19 CD cord-274510-fo7p98np 7 28 ) ) -RRB- cord-274510-fo7p98np 7 29 pandemic pandemic NN cord-274510-fo7p98np 7 30 . . . cord-274510-fo7p98np 8 1 As as IN cord-274510-fo7p98np 8 2 of of IN cord-274510-fo7p98np 8 3 August August NNP cord-274510-fo7p98np 8 4 16 16 CD cord-274510-fo7p98np 8 5 , , , cord-274510-fo7p98np 8 6 2020 2020 CD cord-274510-fo7p98np 8 7 , , , cord-274510-fo7p98np 8 8 the the DT cord-274510-fo7p98np 8 9 severe severe JJ cord-274510-fo7p98np 8 10 acute acute JJ cord-274510-fo7p98np 8 11 respiratory respiratory JJ cord-274510-fo7p98np 8 12 syndrome syndrome NN cord-274510-fo7p98np 8 13 coronavirus coronavirus NN cord-274510-fo7p98np 8 14 2 2 CD cord-274510-fo7p98np 8 15 ( ( -LRB- cord-274510-fo7p98np 8 16 SARS SARS NNP cord-274510-fo7p98np 8 17 - - HYPH cord-274510-fo7p98np 8 18 CoV-2 CoV-2 NNP cord-274510-fo7p98np 8 19 ) ) -RRB- cord-274510-fo7p98np 8 20 has have VBZ cord-274510-fo7p98np 8 21 been be VBN cord-274510-fo7p98np 8 22 responsible responsible JJ cord-274510-fo7p98np 8 23 for for IN cord-274510-fo7p98np 8 24 more more JJR cord-274510-fo7p98np 8 25 than than IN cord-274510-fo7p98np 8 26 21 21 CD cord-274510-fo7p98np 8 27 294 294 CD cord-274510-fo7p98np 8 28 000 000 CD cord-274510-fo7p98np 8 29 infections infection NNS cord-274510-fo7p98np 8 30 and and CC cord-274510-fo7p98np 8 31 about about RB cord-274510-fo7p98np 8 32 760 760 CD cord-274510-fo7p98np 8 33 000 000 CD cord-274510-fo7p98np 8 34 deaths death NNS cord-274510-fo7p98np 8 35 worldwide worldwide RB cord-274510-fo7p98np 8 36 [ [ -LRB- cord-274510-fo7p98np 8 37 1 1 CD cord-274510-fo7p98np 8 38 ] ] -RRB- cord-274510-fo7p98np 8 39 , , , cord-274510-fo7p98np 8 40 but but CC cord-274510-fo7p98np 8 41 the the DT cord-274510-fo7p98np 8 42 mechanisms mechanism NNS cord-274510-fo7p98np 8 43 of of IN cord-274510-fo7p98np 8 44 virus virus NN cord-274510-fo7p98np 8 45 - - HYPH cord-274510-fo7p98np 8 46 induced induce VBN cord-274510-fo7p98np 8 47 host host NN cord-274510-fo7p98np 8 48 damage damage NN cord-274510-fo7p98np 8 49 remain remain VBP cord-274510-fo7p98np 8 50 a a DT cord-274510-fo7p98np 8 51 mystery mystery NN cord-274510-fo7p98np 8 52 . . . cord-274510-fo7p98np 9 1 Understanding understand VBG cord-274510-fo7p98np 9 2 the the DT cord-274510-fo7p98np 9 3 pathways pathway NNS cord-274510-fo7p98np 9 4 behind behind IN cord-274510-fo7p98np 9 5 viral viral JJ cord-274510-fo7p98np 9 6 pathogenicity pathogenicity NN cord-274510-fo7p98np 9 7 just just RB cord-274510-fo7p98np 9 8 like like IN cord-274510-fo7p98np 9 9 cellular cellular JJ cord-274510-fo7p98np 9 10 and and CC cord-274510-fo7p98np 9 11 tissue tissue NN cord-274510-fo7p98np 9 12 tropism tropism NN cord-274510-fo7p98np 9 13 , , , cord-274510-fo7p98np 9 14 counteracting counteract VBG cord-274510-fo7p98np 9 15 host host NN cord-274510-fo7p98np 9 16 defence defence NN cord-274510-fo7p98np 9 17 processes process NNS cord-274510-fo7p98np 9 18 and and CC cord-274510-fo7p98np 9 19 immunological immunological JJ cord-274510-fo7p98np 9 20 responses response NNS cord-274510-fo7p98np 9 21 are be VBP cord-274510-fo7p98np 9 22 crucial crucial JJ cord-274510-fo7p98np 9 23 to to TO cord-274510-fo7p98np 9 24 find find VB cord-274510-fo7p98np 9 25 new new JJ cord-274510-fo7p98np 9 26 therapeutic therapeutic JJ cord-274510-fo7p98np 9 27 strategies strategy NNS cord-274510-fo7p98np 9 28 . . . cord-274510-fo7p98np 10 1 Based base VBN cord-274510-fo7p98np 10 2 on on IN cord-274510-fo7p98np 10 3 clinical clinical JJ cord-274510-fo7p98np 10 4 reports report NNS cord-274510-fo7p98np 10 5 , , , cord-274510-fo7p98np 10 6 it -PRON- PRP cord-274510-fo7p98np 10 7 is be VBZ cord-274510-fo7p98np 10 8 noteworthy noteworthy JJ cord-274510-fo7p98np 10 9 that that IN cord-274510-fo7p98np 10 10 COVID-19 COVID-19 NNP cord-274510-fo7p98np 10 11 causes cause VBZ cord-274510-fo7p98np 10 12 various various JJ cord-274510-fo7p98np 10 13 degree degree NN cord-274510-fo7p98np 10 14 of of IN cord-274510-fo7p98np 10 15 illness illness NN cord-274510-fo7p98np 10 16 ranging range VBG cord-274510-fo7p98np 10 17 from from IN cord-274510-fo7p98np 10 18 asymptomatic asymptomatic JJ cord-274510-fo7p98np 10 19 or or CC cord-274510-fo7p98np 10 20 milder mild JJR cord-274510-fo7p98np 10 21 symptomatic symptomatic JJ cord-274510-fo7p98np 10 22 cases case NNS cord-274510-fo7p98np 10 23 to to IN cord-274510-fo7p98np 10 24 severe severe JJ cord-274510-fo7p98np 10 25 lung lung NN cord-274510-fo7p98np 10 26 injury injury NN cord-274510-fo7p98np 10 27 or or CC cord-274510-fo7p98np 10 28 even even RB cord-274510-fo7p98np 10 29 multi multi JJ cord-274510-fo7p98np 10 30 - - JJ cord-274510-fo7p98np 10 31 organ organ JJ cord-274510-fo7p98np 10 32 dysfunction dysfunction NN cord-274510-fo7p98np 10 33 with with IN cord-274510-fo7p98np 10 34 liver liver NN cord-274510-fo7p98np 10 35 and and CC cord-274510-fo7p98np 10 36 kidney kidney NN cord-274510-fo7p98np 10 37 impairment impairment NN cord-274510-fo7p98np 10 38 [ [ -LRB- cord-274510-fo7p98np 10 39 2 2 CD cord-274510-fo7p98np 10 40 ] ] -RRB- cord-274510-fo7p98np 10 41 [ [ -LRB- cord-274510-fo7p98np 10 42 3 3 CD cord-274510-fo7p98np 10 43 ] ] -RRB- cord-274510-fo7p98np 10 44 [ [ -LRB- cord-274510-fo7p98np 10 45 4 4 CD cord-274510-fo7p98np 10 46 ] ] -RRB- cord-274510-fo7p98np 10 47 . . . cord-274510-fo7p98np 11 1 Even even RB cord-274510-fo7p98np 11 2 in in IN cord-274510-fo7p98np 11 3 not not RB cord-274510-fo7p98np 11 4 severe severe JJ cord-274510-fo7p98np 11 5 patients patient NNS cord-274510-fo7p98np 11 6 , , , cord-274510-fo7p98np 11 7 the the DT cord-274510-fo7p98np 11 8 heterogeneity heterogeneity NN cord-274510-fo7p98np 11 9 of of IN cord-274510-fo7p98np 11 10 symptoms symptom NNS cord-274510-fo7p98np 11 11 is be VBZ cord-274510-fo7p98np 11 12 consistent consistent JJ cord-274510-fo7p98np 11 13 with with IN cord-274510-fo7p98np 11 14 the the DT cord-274510-fo7p98np 11 15 increasing increase VBG cord-274510-fo7p98np 11 16 evidence evidence NN cord-274510-fo7p98np 11 17 that that IN cord-274510-fo7p98np 11 18 SARS SARS NNP cord-274510-fo7p98np 11 19 - - HYPH cord-274510-fo7p98np 11 20 CoV-2 CoV-2 NNP cord-274510-fo7p98np 11 21 shows show VBZ cord-274510-fo7p98np 11 22 a a DT cord-274510-fo7p98np 11 23 broad broad JJ cord-274510-fo7p98np 11 24 tissue tissue NN cord-274510-fo7p98np 11 25 tropism tropism NN cord-274510-fo7p98np 11 26 , , , cord-274510-fo7p98np 11 27 being be VBG cord-274510-fo7p98np 11 28 able able JJ cord-274510-fo7p98np 11 29 to to TO cord-274510-fo7p98np 11 30 attack attack VB cord-274510-fo7p98np 11 31 almost almost RB cord-274510-fo7p98np 11 32 anything anything NN cord-274510-fo7p98np 11 33 in in IN cord-274510-fo7p98np 11 34 the the DT cord-274510-fo7p98np 11 35 body body NN cord-274510-fo7p98np 11 36 [ [ -LRB- cord-274510-fo7p98np 11 37 2 2 CD cord-274510-fo7p98np 11 38 ] ] -RRB- cord-274510-fo7p98np 11 39 [ [ -LRB- cord-274510-fo7p98np 11 40 3 3 CD cord-274510-fo7p98np 11 41 ] ] -RRB- cord-274510-fo7p98np 11 42 [ [ -LRB- cord-274510-fo7p98np 11 43 4 4 CD cord-274510-fo7p98np 11 44 ] ] -RRB- cord-274510-fo7p98np 11 45 [ [ -LRB- cord-274510-fo7p98np 11 46 5 5 CD cord-274510-fo7p98np 11 47 ] ] -RRB- cord-274510-fo7p98np 11 48 . . . cord-274510-fo7p98np 12 1 To to IN cord-274510-fo7p98np 12 2 date date NN cord-274510-fo7p98np 12 3 , , , cord-274510-fo7p98np 12 4 the the DT cord-274510-fo7p98np 12 5 most most RBS cord-274510-fo7p98np 12 6 commonly commonly RB cord-274510-fo7p98np 12 7 investigated investigate VBN cord-274510-fo7p98np 12 8 hypothesis hypothesis NN cord-274510-fo7p98np 12 9 about about IN cord-274510-fo7p98np 12 10 the the DT cord-274510-fo7p98np 12 11 underlying underlie VBG cord-274510-fo7p98np 12 12 mechanisms mechanism NNS cord-274510-fo7p98np 12 13 of of IN cord-274510-fo7p98np 12 14 multi multi JJ cord-274510-fo7p98np 12 15 - - JJ cord-274510-fo7p98np 12 16 organ organ JJ cord-274510-fo7p98np 12 17 failure failure NN cord-274510-fo7p98np 12 18 may may MD cord-274510-fo7p98np 12 19 be be VB cord-274510-fo7p98np 12 20 summarized summarize VBN cord-274510-fo7p98np 12 21 into into IN cord-274510-fo7p98np 12 22 three three CD cord-274510-fo7p98np 12 23 main main JJ cord-274510-fo7p98np 12 24 targets target NNS cord-274510-fo7p98np 12 25 : : : cord-274510-fo7p98np 12 26 microcirculation microcirculation NNP cord-274510-fo7p98np 12 27 dysfunction dysfunction NN cord-274510-fo7p98np 12 28 , , , cord-274510-fo7p98np 12 29 overwhelming overwhelming JJ cord-274510-fo7p98np 12 30 inflammation inflammation NN cord-274510-fo7p98np 12 31 and and CC cord-274510-fo7p98np 12 32 abnormal abnormal JJ cord-274510-fo7p98np 12 33 coagulation coagulation NN cord-274510-fo7p98np 12 34 [ [ -LRB- cord-274510-fo7p98np 12 35 7 7 CD cord-274510-fo7p98np 12 36 ] ] -RRB- cord-274510-fo7p98np 12 37 . . . cord-274510-fo7p98np 13 1 Radiologic radiologic JJ cord-274510-fo7p98np 13 2 and and CC cord-274510-fo7p98np 13 3 laboratory laboratory NN cord-274510-fo7p98np 13 4 findings finding NNS cord-274510-fo7p98np 13 5 as as RB cord-274510-fo7p98np 13 6 well well RB cord-274510-fo7p98np 13 7 as as IN cord-274510-fo7p98np 13 8 preliminary preliminary JJ cord-274510-fo7p98np 13 9 autopsy autopsy JJ cord-274510-fo7p98np 13 10 studies study NNS cord-274510-fo7p98np 13 11 seem seem VBP cord-274510-fo7p98np 13 12 to to TO cord-274510-fo7p98np 13 13 support support VB cord-274510-fo7p98np 13 14 this this DT cord-274510-fo7p98np 13 15 hypothesis hypothesis NN cord-274510-fo7p98np 13 16 . . . cord-274510-fo7p98np 14 1 The the DT cord-274510-fo7p98np 14 2 most most RBS cord-274510-fo7p98np 14 3 common common JJ cord-274510-fo7p98np 14 4 patterns pattern NNS cord-274510-fo7p98np 14 5 seen see VBN cord-274510-fo7p98np 14 6 on on IN cord-274510-fo7p98np 14 7 chest chest NN cord-274510-fo7p98np 14 8 CT CT NNP cord-274510-fo7p98np 14 9 were be VBD cord-274510-fo7p98np 14 10 ground ground NN cord-274510-fo7p98np 14 11 - - HYPH cord-274510-fo7p98np 14 12 glass glass NN cord-274510-fo7p98np 14 13 opacity opacity NN cord-274510-fo7p98np 14 14 , , , cord-274510-fo7p98np 14 15 interlobular interlobular JJ cord-274510-fo7p98np 14 16 septal septal JJ cord-274510-fo7p98np 14 17 thickening thickening NN cord-274510-fo7p98np 14 18 , , , cord-274510-fo7p98np 14 19 air air NN cord-274510-fo7p98np 14 20 bronchogram bronchogram NNP cord-274510-fo7p98np 14 21 , , , cord-274510-fo7p98np 14 22 bilateral bilateral JJ cord-274510-fo7p98np 14 23 patchy patchy JJ cord-274510-fo7p98np 14 24 shadowing shadowing NN cord-274510-fo7p98np 14 25 , , , cord-274510-fo7p98np 14 26 crazy crazy JJ cord-274510-fo7p98np 14 27 - - HYPH cord-274510-fo7p98np 14 28 paving paving JJ cord-274510-fo7p98np 14 29 pattern pattern NN cord-274510-fo7p98np 14 30 , , , cord-274510-fo7p98np 14 31 and and CC cord-274510-fo7p98np 14 32 thickening thickening NN cord-274510-fo7p98np 14 33 of of IN cord-274510-fo7p98np 14 34 the the DT cord-274510-fo7p98np 14 35 adjacent adjacent JJ cord-274510-fo7p98np 14 36 pleura pleura NN cord-274510-fo7p98np 14 37 , , , cord-274510-fo7p98np 14 38 resembling resemble VBG cord-274510-fo7p98np 14 39 an an DT cord-274510-fo7p98np 14 40 interstitial interstitial JJ cord-274510-fo7p98np 14 41 involvement involvement NN cord-274510-fo7p98np 14 42 in in IN cord-274510-fo7p98np 14 43 viral viral JJ cord-274510-fo7p98np 14 44 pneumonia pneumonia NN cord-274510-fo7p98np 14 45 [ [ -LRB- cord-274510-fo7p98np 14 46 2 2 CD cord-274510-fo7p98np 14 47 ] ] -RRB- cord-274510-fo7p98np 14 48 [ [ -LRB- cord-274510-fo7p98np 14 49 3 3 CD cord-274510-fo7p98np 14 50 ] ] -RRB- cord-274510-fo7p98np 14 51 7 7 CD cord-274510-fo7p98np 14 52 ] ] -RRB- cord-274510-fo7p98np 14 53 . . . cord-274510-fo7p98np 15 1 Under under IN cord-274510-fo7p98np 15 2 the the DT cord-274510-fo7p98np 15 3 light light NN cord-274510-fo7p98np 15 4 of of IN cord-274510-fo7p98np 15 5 microscope microscope NN cord-274510-fo7p98np 15 6 , , , cord-274510-fo7p98np 15 7 the the DT cord-274510-fo7p98np 15 8 lungs lung NNS cord-274510-fo7p98np 15 9 revealed reveal VBD cord-274510-fo7p98np 15 10 diffuse diffuse JJ cord-274510-fo7p98np 15 11 alveolar alveolar NN cord-274510-fo7p98np 15 12 damage damage NN cord-274510-fo7p98np 15 13 with with IN cord-274510-fo7p98np 15 14 formation formation NN cord-274510-fo7p98np 15 15 of of IN cord-274510-fo7p98np 15 16 numerous numerous JJ cord-274510-fo7p98np 15 17 hyaline hyaline JJ cord-274510-fo7p98np 15 18 membranes membrane NNS cord-274510-fo7p98np 15 19 , , , cord-274510-fo7p98np 15 20 very very RB cord-274510-fo7p98np 15 21 patchy patchy JJ cord-274510-fo7p98np 15 22 and and CC cord-274510-fo7p98np 15 23 sparse sparse JJ cord-274510-fo7p98np 15 24 interstitial interstitial JJ cord-274510-fo7p98np 15 25 chronic chronic JJ cord-274510-fo7p98np 15 26 inflammation inflammation NN cord-274510-fo7p98np 15 27 composed compose VBN cord-274510-fo7p98np 15 28 mainly mainly RB cord-274510-fo7p98np 15 29 of of IN cord-274510-fo7p98np 15 30 lymphocytes lymphocyte NNS cord-274510-fo7p98np 15 31 , , , cord-274510-fo7p98np 15 32 thrombi thrombi NNP cord-274510-fo7p98np 15 33 within within IN cord-274510-fo7p98np 15 34 a a DT cord-274510-fo7p98np 15 35 few few JJ cord-274510-fo7p98np 15 36 small small JJ cord-274510-fo7p98np 15 37 pulmonary pulmonary JJ cord-274510-fo7p98np 15 38 artery artery NN cord-274510-fo7p98np 15 39 branches branch NNS cord-274510-fo7p98np 15 40 , , , cord-274510-fo7p98np 15 41 congestion congestion NN cord-274510-fo7p98np 15 42 of of IN cord-274510-fo7p98np 15 43 alveolar alveolar JJ cord-274510-fo7p98np 15 44 septal septal JJ cord-274510-fo7p98np 15 45 capillaries capillary NNS cord-274510-fo7p98np 15 46 , , , cord-274510-fo7p98np 15 47 focal focal JJ cord-274510-fo7p98np 15 48 edema edema NN cord-274510-fo7p98np 15 49 fluid fluid NN cord-274510-fo7p98np 15 50 , , , cord-274510-fo7p98np 15 51 and and CC cord-274510-fo7p98np 15 52 macrophage macrophage NN cord-274510-fo7p98np 15 53 infiltration infiltration NN cord-274510-fo7p98np 15 54 within within IN cord-274510-fo7p98np 15 55 the the DT cord-274510-fo7p98np 15 56 airspaces airspace NNS cord-274510-fo7p98np 15 57 [ [ -LRB- cord-274510-fo7p98np 15 58 9 9 CD cord-274510-fo7p98np 15 59 ] ] -RRB- cord-274510-fo7p98np 15 60 [ [ -LRB- cord-274510-fo7p98np 15 61 10 10 CD cord-274510-fo7p98np 15 62 ] ] -RRB- cord-274510-fo7p98np 15 63 [ [ -LRB- cord-274510-fo7p98np 15 64 11 11 CD cord-274510-fo7p98np 15 65 ] ] -RRB- cord-274510-fo7p98np 15 66 [ [ -LRB- cord-274510-fo7p98np 15 67 12 12 CD cord-274510-fo7p98np 15 68 ] ] -RRB- cord-274510-fo7p98np 15 69 . . . cord-274510-fo7p98np 16 1 The the DT cord-274510-fo7p98np 16 2 more more RBR cord-274510-fo7p98np 16 3 significant significant JJ cord-274510-fo7p98np 16 4 laboratory laboratory NN cord-274510-fo7p98np 16 5 abnormalities abnormality NNS cord-274510-fo7p98np 16 6 were be VBD cord-274510-fo7p98np 16 7 metabolic metabolic JJ cord-274510-fo7p98np 16 8 acidosis acidosis NN cord-274510-fo7p98np 16 9 , , , cord-274510-fo7p98np 16 10 lymphocytopenia lymphocytopenia NNP cord-274510-fo7p98np 16 11 , , , cord-274510-fo7p98np 16 12 leukopenia leukopenia NN cord-274510-fo7p98np 16 13 , , , cord-274510-fo7p98np 16 14 thrombocytopenia thrombocytopenia NN cord-274510-fo7p98np 16 15 , , , cord-274510-fo7p98np 16 16 elevated elevated JJ cord-274510-fo7p98np 16 17 levels level NNS cord-274510-fo7p98np 16 18 of of IN cord-274510-fo7p98np 16 19 Creactive Creactive NNP cord-274510-fo7p98np 16 20 protein protein NN cord-274510-fo7p98np 16 21 ( ( -LRB- cord-274510-fo7p98np 16 22 CRP CRP NNP cord-274510-fo7p98np 16 23 ) ) -RRB- cord-274510-fo7p98np 16 24 , , , cord-274510-fo7p98np 16 25 interleukin-6 interleukin-6 NNP cord-274510-fo7p98np 16 26 ( ( -LRB- cord-274510-fo7p98np 16 27 IL-6 IL-6 NNP cord-274510-fo7p98np 16 28 ) ) -RRB- cord-274510-fo7p98np 16 29 , , , cord-274510-fo7p98np 16 30 lactate lactate NN cord-274510-fo7p98np 16 31 dehydrogenase dehydrogenase NN cord-274510-fo7p98np 16 32 ( ( -LRB- cord-274510-fo7p98np 16 33 LDH LDH NNP cord-274510-fo7p98np 16 34 ) ) -RRB- cord-274510-fo7p98np 16 35 and and CC cord-274510-fo7p98np 16 36 D d NN cord-274510-fo7p98np 16 37 - - HYPH cord-274510-fo7p98np 16 38 dimer dimer NN cord-274510-fo7p98np 16 39 [ [ -LRB- cord-274510-fo7p98np 16 40 2 2 CD cord-274510-fo7p98np 16 41 ] ] -RRB- cord-274510-fo7p98np 16 42 [ [ -LRB- cord-274510-fo7p98np 16 43 3 3 CD cord-274510-fo7p98np 16 44 ] ] -RRB- cord-274510-fo7p98np 16 45 [ [ -LRB- cord-274510-fo7p98np 16 46 4 4 CD cord-274510-fo7p98np 16 47 ] ] -RRB- cord-274510-fo7p98np 16 48 [ [ -LRB- cord-274510-fo7p98np 16 49 5 5 CD cord-274510-fo7p98np 16 50 ] ] -RRB- cord-274510-fo7p98np 16 51 [ [ -LRB- cord-274510-fo7p98np 16 52 6 6 CD cord-274510-fo7p98np 16 53 ] ] -RRB- cord-274510-fo7p98np 16 54 [ [ -LRB- cord-274510-fo7p98np 16 55 7 7 CD cord-274510-fo7p98np 16 56 ] ] -RRB- cord-274510-fo7p98np 16 57 . . . cord-274510-fo7p98np 17 1 As as IN cord-274510-fo7p98np 17 2 firstly firstly RB cord-274510-fo7p98np 17 3 suggested suggest VBN cord-274510-fo7p98np 17 4 by by IN cord-274510-fo7p98np 17 5 Huang Huang NNP cord-274510-fo7p98np 17 6 C C NNP cord-274510-fo7p98np 17 7 et et NNP cord-274510-fo7p98np 17 8 al al NNP cord-274510-fo7p98np 17 9 . . . cord-274510-fo7p98np 18 1 [ [ -LRB- cord-274510-fo7p98np 18 2 4 4 CD cord-274510-fo7p98np 18 3 ] ] -RRB- cord-274510-fo7p98np 18 4 , , , cord-274510-fo7p98np 18 5 the the DT cord-274510-fo7p98np 18 6 systemic systemic JJ cord-274510-fo7p98np 18 7 cytokine cytokine NN cord-274510-fo7p98np 18 8 storm storm NN cord-274510-fo7p98np 18 9 could could MD cord-274510-fo7p98np 18 10 play play VB cord-274510-fo7p98np 18 11 a a DT cord-274510-fo7p98np 18 12 key key JJ cord-274510-fo7p98np 18 13 role role NN cord-274510-fo7p98np 18 14 in in IN cord-274510-fo7p98np 18 15 the the DT cord-274510-fo7p98np 18 16 virusinduced virusinduce VBN cord-274510-fo7p98np 18 17 tissue tissue NN cord-274510-fo7p98np 18 18 damage damage NN cord-274510-fo7p98np 18 19 . . . cord-274510-fo7p98np 19 1 However however RB cord-274510-fo7p98np 19 2 , , , cord-274510-fo7p98np 19 3 the the DT cord-274510-fo7p98np 19 4 question question NN cord-274510-fo7p98np 19 5 " " `` cord-274510-fo7p98np 19 6 what what WP cord-274510-fo7p98np 19 7 the the DT cord-274510-fo7p98np 19 8 link link NN cord-274510-fo7p98np 19 9 for for IN cord-274510-fo7p98np 19 10 the the DT cord-274510-fo7p98np 19 11 overproduction overproduction NN cord-274510-fo7p98np 19 12 of of IN cord-274510-fo7p98np 19 13 proinflammatory proinflammatory JJ cord-274510-fo7p98np 19 14 mediators mediator NNS cord-274510-fo7p98np 19 15 and and CC cord-274510-fo7p98np 19 16 the the DT cord-274510-fo7p98np 19 17 immune immune JJ cord-274510-fo7p98np 19 18 suppression suppression NN cord-274510-fo7p98np 19 19 , , , cord-274510-fo7p98np 19 20 on on IN cord-274510-fo7p98np 19 21 the the DT cord-274510-fo7p98np 19 22 hand hand NN cord-274510-fo7p98np 19 23 , , , cord-274510-fo7p98np 19 24 and and CC cord-274510-fo7p98np 19 25 microvascular microvascular JJ cord-274510-fo7p98np 19 26 injury injury NN cord-274510-fo7p98np 19 27 and and CC cord-274510-fo7p98np 19 28 thromboembolism thromboembolism NN cord-274510-fo7p98np 19 29 , , , cord-274510-fo7p98np 19 30 on on IN cord-274510-fo7p98np 19 31 the the DT cord-274510-fo7p98np 19 32 other other JJ cord-274510-fo7p98np 19 33 , , , cord-274510-fo7p98np 19 34 is be VBZ cord-274510-fo7p98np 19 35 " " `` cord-274510-fo7p98np 19 36 , , , cord-274510-fo7p98np 19 37 remains remain VBZ cord-274510-fo7p98np 19 38 unclear unclear JJ cord-274510-fo7p98np 19 39 . . . cord-274510-fo7p98np 20 1 Being be VBG cord-274510-fo7p98np 20 2 the the DT cord-274510-fo7p98np 20 3 knowledge knowledge NN cord-274510-fo7p98np 20 4 of of IN cord-274510-fo7p98np 20 5 this this DT cord-274510-fo7p98np 20 6 issue issue NN cord-274510-fo7p98np 20 7 very very RB cord-274510-fo7p98np 20 8 scarce scarce JJ cord-274510-fo7p98np 20 9 , , , cord-274510-fo7p98np 20 10 lessons lesson NNS cord-274510-fo7p98np 20 11 learned learn VBN cord-274510-fo7p98np 20 12 from from IN cord-274510-fo7p98np 20 13 other other JJ cord-274510-fo7p98np 20 14 human human JJ cord-274510-fo7p98np 20 15 pathogenic pathogenic JJ cord-274510-fo7p98np 20 16 viruses virus NNS cord-274510-fo7p98np 20 17 , , , cord-274510-fo7p98np 20 18 with with IN cord-274510-fo7p98np 20 19 specific specific JJ cord-274510-fo7p98np 20 20 reference reference NN cord-274510-fo7p98np 20 21 to to IN cord-274510-fo7p98np 20 22 human human JJ cord-274510-fo7p98np 20 23 immunodeficiency immunodeficiency NN cord-274510-fo7p98np 20 24 virus virus NN cord-274510-fo7p98np 20 25 ( ( -LRB- cord-274510-fo7p98np 20 26 HIV HIV NNP cord-274510-fo7p98np 20 27 ) ) -RRB- cord-274510-fo7p98np 20 28 , , , cord-274510-fo7p98np 20 29 could could MD cord-274510-fo7p98np 20 30 be be VB cord-274510-fo7p98np 20 31 diriment diriment VBN cord-274510-fo7p98np 20 32 . . . cord-274510-fo7p98np 21 1 Based base VBN cord-274510-fo7p98np 21 2 on on IN cord-274510-fo7p98np 21 3 the the DT cord-274510-fo7p98np 21 4 aforementioned aforementioned JJ cord-274510-fo7p98np 21 5 findings finding NNS cord-274510-fo7p98np 21 6 and and CC cord-274510-fo7p98np 21 7 on on IN cord-274510-fo7p98np 21 8 documented document VBN cord-274510-fo7p98np 21 9 analogies analogy NNS cord-274510-fo7p98np 21 10 between between IN cord-274510-fo7p98np 21 11 SARS SARS NNP cord-274510-fo7p98np 21 12 - - HYPH cord-274510-fo7p98np 21 13 CoV-2 CoV-2 NNP cord-274510-fo7p98np 21 14 and and CC cord-274510-fo7p98np 21 15 HIV HIV NNP cord-274510-fo7p98np 21 16 [ [ -LRB- cord-274510-fo7p98np 21 17 13 13 CD cord-274510-fo7p98np 21 18 ] ] -RRB- cord-274510-fo7p98np 21 19 , , , cord-274510-fo7p98np 21 20 we -PRON- PRP cord-274510-fo7p98np 21 21 hypothesized hypothesize VBD cord-274510-fo7p98np 21 22 that that IN cord-274510-fo7p98np 21 23 the the DT cord-274510-fo7p98np 21 24 reduced reduce VBN cord-274510-fo7p98np 21 25 conversion conversion NN cord-274510-fo7p98np 21 26 activity activity NN cord-274510-fo7p98np 21 27 of of IN cord-274510-fo7p98np 21 28 the the DT cord-274510-fo7p98np 21 29 Gc Gc NNP cord-274510-fo7p98np 21 30 protein protein NN cord-274510-fo7p98np 21 31 ( ( -LRB- cord-274510-fo7p98np 21 32 human human JJ cord-274510-fo7p98np 21 33 groupspecific groupspecific NNP cord-274510-fo7p98np 21 34 component component NN cord-274510-fo7p98np 21 35 ( ( -LRB- cord-274510-fo7p98np 21 36 Gc Gc NNP cord-274510-fo7p98np 21 37 ) ) -RRB- cord-274510-fo7p98np 21 38 ) ) -RRB- cord-274510-fo7p98np 21 39 into into IN cord-274510-fo7p98np 21 40 the the DT cord-274510-fo7p98np 21 41 macrophage macrophage NN cord-274510-fo7p98np 21 42 activating activate VBG cord-274510-fo7p98np 21 43 factor factor NN cord-274510-fo7p98np 21 44 ( ( -LRB- cord-274510-fo7p98np 21 45 MAF MAF NNP cord-274510-fo7p98np 21 46 ) ) -RRB- cord-274510-fo7p98np 21 47 could could MD cord-274510-fo7p98np 21 48 have have VB cord-274510-fo7p98np 21 49 a a DT cord-274510-fo7p98np 21 50 key key JJ cord-274510-fo7p98np 21 51 role role NN cord-274510-fo7p98np 21 52 in in IN cord-274510-fo7p98np 21 53 the the DT cord-274510-fo7p98np 21 54 dysregulate dysregulate NN cord-274510-fo7p98np 21 55 immune immune JJ cord-274510-fo7p98np 21 56 response response NN cord-274510-fo7p98np 21 57 induced induce VBN cord-274510-fo7p98np 21 58 by by IN cord-274510-fo7p98np 21 59 SARS SARS NNP cord-274510-fo7p98np 21 60 - - HYPH cord-274510-fo7p98np 21 61 CoV-2 CoV-2 NNP cord-274510-fo7p98np 21 62 , , , cord-274510-fo7p98np 21 63 just just RB cord-274510-fo7p98np 21 64 like like IN cord-274510-fo7p98np 21 65 for for IN cord-274510-fo7p98np 21 66 HIV HIV NNP cord-274510-fo7p98np 21 67 infected infect VBN cord-274510-fo7p98np 21 68 patients patient NNS cord-274510-fo7p98np 21 69 [ [ -LRB- cord-274510-fo7p98np 21 70 14 14 CD cord-274510-fo7p98np 21 71 ] ] -RRB- cord-274510-fo7p98np 21 72 [ [ -LRB- cord-274510-fo7p98np 21 73 15 15 CD cord-274510-fo7p98np 21 74 ] ] -RRB- cord-274510-fo7p98np 21 75 . . . cord-274510-fo7p98np 22 1 If if IN cord-274510-fo7p98np 22 2 this this DT cord-274510-fo7p98np 22 3 hypothesis hypothesis NN cord-274510-fo7p98np 22 4 is be VBZ cord-274510-fo7p98np 22 5 correct correct JJ cord-274510-fo7p98np 22 6 , , , cord-274510-fo7p98np 22 7 it -PRON- PRP cord-274510-fo7p98np 22 8 might may MD cord-274510-fo7p98np 22 9 help help VB cord-274510-fo7p98np 22 10 to to TO cord-274510-fo7p98np 22 11 set set VB cord-274510-fo7p98np 22 12 a a DT cord-274510-fo7p98np 22 13 valid valid JJ cord-274510-fo7p98np 22 14 strategy strategy NN cord-274510-fo7p98np 22 15 of of IN cord-274510-fo7p98np 22 16 immunotherapy immunotherapy NN cord-274510-fo7p98np 22 17 also also RB cord-274510-fo7p98np 22 18 based base VBN cord-274510-fo7p98np 22 19 on on IN cord-274510-fo7p98np 22 20 an an DT cord-274510-fo7p98np 22 21 off off JJ cord-274510-fo7p98np 22 22 - - HYPH cord-274510-fo7p98np 22 23 label label NN cord-274510-fo7p98np 22 24 use use NN cord-274510-fo7p98np 22 25 of of IN cord-274510-fo7p98np 22 26 GcMAF GcMAF NNP cord-274510-fo7p98np 22 27 in in IN cord-274510-fo7p98np 22 28 critically critically RB cord-274510-fo7p98np 22 29 ill ill JJ cord-274510-fo7p98np 22 30 COVID-19 covid-19 CD cord-274510-fo7p98np 22 31 patients patient NNS cord-274510-fo7p98np 22 32 . . . cord-274510-fo7p98np 23 1 Gc Gc NNP cord-274510-fo7p98np 23 2 globulin globulin NN cord-274510-fo7p98np 23 3 , , , cord-274510-fo7p98np 23 4 DBP DBP NNP cord-274510-fo7p98np 23 5 and and CC cord-274510-fo7p98np 23 6 GcMAF GcMAF NNPS cord-274510-fo7p98np 23 7 : : : cord-274510-fo7p98np 24 1 three three CD cord-274510-fo7p98np 24 2 in in IN cord-274510-fo7p98np 24 3 one one CD cord-274510-fo7p98np 24 4 . . . cord-274510-fo7p98np 25 1 Serum serum NN cord-274510-fo7p98np 25 2 Gc Gc NNP cord-274510-fo7p98np 25 3 protein protein NN cord-274510-fo7p98np 25 4 , , , cord-274510-fo7p98np 25 5 also also RB cord-274510-fo7p98np 25 6 known know VBN cord-274510-fo7p98np 25 7 as as IN cord-274510-fo7p98np 25 8 vitamin vitamin NN cord-274510-fo7p98np 25 9 D d NN cord-274510-fo7p98np 25 10 - - HYPH cord-274510-fo7p98np 25 11 binding bind VBG cord-274510-fo7p98np 25 12 protein protein NN cord-274510-fo7p98np 25 13 ( ( -LRB- cord-274510-fo7p98np 25 14 DBP DBP NNP cord-274510-fo7p98np 25 15 ) ) -RRB- cord-274510-fo7p98np 25 16 , , , cord-274510-fo7p98np 25 17 is be VBZ cord-274510-fo7p98np 25 18 a a DT cord-274510-fo7p98np 25 19 multifunctional multifunctional JJ cord-274510-fo7p98np 25 20 protein protein NN cord-274510-fo7p98np 25 21 present present NN cord-274510-fo7p98np 25 22 in in IN cord-274510-fo7p98np 25 23 plasma plasma NN cord-274510-fo7p98np 25 24 / / SYM cord-274510-fo7p98np 25 25 serum serum NN cord-274510-fo7p98np 25 26 at at IN cord-274510-fo7p98np 25 27 concentrations concentration NNS cord-274510-fo7p98np 25 28 of of IN cord-274510-fo7p98np 25 29 300 300 CD cord-274510-fo7p98np 25 30 - - SYM cord-274510-fo7p98np 25 31 600 600 CD cord-274510-fo7p98np 25 32 mg mg NNP cord-274510-fo7p98np 25 33 / / SYM cord-274510-fo7p98np 25 34 L L NNP cord-274510-fo7p98np 25 35 [ [ -LRB- cord-274510-fo7p98np 25 36 16 16 CD cord-274510-fo7p98np 25 37 ] ] -RRB- cord-274510-fo7p98np 25 38 . . . cord-274510-fo7p98np 26 1 It -PRON- PRP cord-274510-fo7p98np 26 2 carries carry VBZ cord-274510-fo7p98np 26 3 a a DT cord-274510-fo7p98np 26 4 trisaccharide trisaccharide NN cord-274510-fo7p98np 26 5 consisting consist VBG cord-274510-fo7p98np 26 6 of of IN cord-274510-fo7p98np 26 7 N n CD cord-274510-fo7p98np 26 8 - - HYPH cord-274510-fo7p98np 26 9 acetylgalactosamine acetylgalactosamine NNP cord-274510-fo7p98np 26 10 with with IN cord-274510-fo7p98np 26 11 dibranched dibranched JJ cord-274510-fo7p98np 26 12 galactose galactose NN cord-274510-fo7p98np 26 13 and and CC cord-274510-fo7p98np 26 14 sialic sialic NN cord-274510-fo7p98np 26 15 acid acid NN cord-274510-fo7p98np 26 16 termini terminus NNS cord-274510-fo7p98np 26 17 at at IN cord-274510-fo7p98np 26 18 420 420 CD cord-274510-fo7p98np 26 19 threonine threonine NN cord-274510-fo7p98np 26 20 residue residue NN cord-274510-fo7p98np 26 21 [ [ -LRB- cord-274510-fo7p98np 26 22 17 17 CD cord-274510-fo7p98np 26 23 ] ] -RRB- cord-274510-fo7p98np 26 24 . . . cord-274510-fo7p98np 27 1 Stepwise stepwise JJ cord-274510-fo7p98np 27 2 hydrolysis hydrolysis NN cord-274510-fo7p98np 27 3 of of IN cord-274510-fo7p98np 27 4 Gc Gc NNP cord-274510-fo7p98np 27 5 protein protein NN cord-274510-fo7p98np 27 6 by by IN cord-274510-fo7p98np 27 7 the the DT cord-274510-fo7p98np 27 8 inducible inducible JJ cord-274510-fo7p98np 27 9 membranous membranous JJ cord-274510-fo7p98np 27 10 βgalactosidase βgalactosidase NN cord-274510-fo7p98np 27 11 of of IN cord-274510-fo7p98np 27 12 stimulated stimulate VBN cord-274510-fo7p98np 27 13 B b NN cord-274510-fo7p98np 27 14 - - HYPH cord-274510-fo7p98np 27 15 lymphocytes lymphocyte NNS cord-274510-fo7p98np 27 16 , , , cord-274510-fo7p98np 27 17 and and CC cord-274510-fo7p98np 28 1 by by IN cord-274510-fo7p98np 28 2 the the DT cord-274510-fo7p98np 28 3 Neu-1 Neu-1 NNP cord-274510-fo7p98np 28 4 sialidase sialidase NN cord-274510-fo7p98np 28 5 of of IN cord-274510-fo7p98np 28 6 T t NN cord-274510-fo7p98np 28 7 - - HYPH cord-274510-fo7p98np 28 8 lymphocytes lymphocyte NNS cord-274510-fo7p98np 28 9 converts convert VBZ cord-274510-fo7p98np 28 10 it -PRON- PRP cord-274510-fo7p98np 28 11 into into IN cord-274510-fo7p98np 28 12 the the DT cord-274510-fo7p98np 28 13 active active JJ cord-274510-fo7p98np 28 14 GcMAF GcMAF NNPS cord-274510-fo7p98np 29 1 [ [ -LRB- cord-274510-fo7p98np 29 2 17 17 CD cord-274510-fo7p98np 29 3 ] ] -RRB- cord-274510-fo7p98np 29 4 [ [ -LRB- cord-274510-fo7p98np 29 5 18 18 CD cord-274510-fo7p98np 29 6 ] ] -RRB- cord-274510-fo7p98np 29 7 [ [ -LRB- cord-274510-fo7p98np 29 8 19 19 CD cord-274510-fo7p98np 29 9 ] ] -RRB- cord-274510-fo7p98np 29 10 . . . cord-274510-fo7p98np 30 1 On on IN cord-274510-fo7p98np 30 2 the the DT cord-274510-fo7p98np 30 3 contrary contrary NN cord-274510-fo7p98np 30 4 , , , cord-274510-fo7p98np 30 5 deglycosilation deglycosilation NN cord-274510-fo7p98np 30 6 of of IN cord-274510-fo7p98np 30 7 Gc Gc NNP cord-274510-fo7p98np 30 8 protein protein NN cord-274510-fo7p98np 30 9 by by IN cord-274510-fo7p98np 30 10 action action NN cord-274510-fo7p98np 30 11 of of IN cord-274510-fo7p98np 30 12 the the DT cord-274510-fo7p98np 30 13 enzyme enzyme NN cord-274510-fo7p98np 30 14 alpha alpha NN cord-274510-fo7p98np 30 15 - - HYPH cord-274510-fo7p98np 30 16 N n NN cord-274510-fo7p98np 30 17 - - HYPH cord-274510-fo7p98np 30 18 acetylgalactosaminidase acetylgalactosaminidase NNP cord-274510-fo7p98np 30 19 , , , cord-274510-fo7p98np 30 20 named name VBN cord-274510-fo7p98np 30 21 nagalase nagalase NN cord-274510-fo7p98np 30 22 , , , cord-274510-fo7p98np 30 23 secreted secrete VBN cord-274510-fo7p98np 30 24 from from IN cord-274510-fo7p98np 30 25 HIV HIV NNP cord-274510-fo7p98np 30 26 - - HYPH cord-274510-fo7p98np 30 27 infected infect VBN cord-274510-fo7p98np 30 28 cells cell NNS cord-274510-fo7p98np 30 29 leads lead VBZ cord-274510-fo7p98np 30 30 to to IN cord-274510-fo7p98np 30 31 lack lack NN cord-274510-fo7p98np 30 32 of of IN cord-274510-fo7p98np 30 33 macrophage macrophage NN cord-274510-fo7p98np 30 34 activation activation NN cord-274510-fo7p98np 30 35 and and CC cord-274510-fo7p98np 30 36 to to IN cord-274510-fo7p98np 30 37 immunosuppression immunosuppression NN cord-274510-fo7p98np 30 38 , , , cord-274510-fo7p98np 30 39 as as IN cord-274510-fo7p98np 30 40 a a DT cord-274510-fo7p98np 30 41 consequence consequence NN cord-274510-fo7p98np 30 42 [ [ -LRB- cord-274510-fo7p98np 30 43 14 14 CD cord-274510-fo7p98np 30 44 ] ] -RRB- cord-274510-fo7p98np 30 45 [ [ -LRB- cord-274510-fo7p98np 30 46 15 15 CD cord-274510-fo7p98np 30 47 ] ] -RRB- cord-274510-fo7p98np 30 48 . . . cord-274510-fo7p98np 31 1 It -PRON- PRP cord-274510-fo7p98np 31 2 is be VBZ cord-274510-fo7p98np 31 3 remarkable remarkable JJ cord-274510-fo7p98np 31 4 that that IN cord-274510-fo7p98np 31 5 nagalase nagalase NNP cord-274510-fo7p98np 31 6 was be VBD cord-274510-fo7p98np 31 7 demonstrated demonstrate VBN cord-274510-fo7p98np 31 8 to to TO cord-274510-fo7p98np 31 9 be be VB cord-274510-fo7p98np 31 10 an an DT cord-274510-fo7p98np 31 11 intrinsic intrinsic JJ cord-274510-fo7p98np 31 12 component component NN cord-274510-fo7p98np 31 13 not not RB cord-274510-fo7p98np 31 14 only only RB cord-274510-fo7p98np 31 15 of of IN cord-274510-fo7p98np 31 16 the the DT cord-274510-fo7p98np 31 17 envelope envelope NN cord-274510-fo7p98np 31 18 glycoproteins glycoprotein NNS cord-274510-fo7p98np 31 19 gp120 gp120 NNP cord-274510-fo7p98np 31 20 and and CC cord-274510-fo7p98np 31 21 gp160 gp160 NN cord-274510-fo7p98np 31 22 of of IN cord-274510-fo7p98np 31 23 HIV HIV NNP cord-274510-fo7p98np 31 24 but but CC cord-274510-fo7p98np 31 25 also also RB cord-274510-fo7p98np 31 26 of of IN cord-274510-fo7p98np 31 27 the the DT cord-274510-fo7p98np 31 28 hemagglutinin hemagglutinin NN cord-274510-fo7p98np 31 29 ( ( -LRB- cord-274510-fo7p98np 31 30 HE HE NNP cord-274510-fo7p98np 31 31 ) ) -RRB- cord-274510-fo7p98np 31 32 of of IN cord-274510-fo7p98np 31 33 influenza influenza NN cord-274510-fo7p98np 31 34 virus virus NN cord-274510-fo7p98np 31 35 [ [ -LRB- cord-274510-fo7p98np 31 36 15 15 CD cord-274510-fo7p98np 31 37 , , , cord-274510-fo7p98np 31 38 20 20 CD cord-274510-fo7p98np 31 39 ] ] -RRB- cord-274510-fo7p98np 31 40 and and CC cord-274510-fo7p98np 31 41 even even RB cord-274510-fo7p98np 31 42 produced produce VBN cord-274510-fo7p98np 31 43 by by IN cord-274510-fo7p98np 31 44 neoplastic neoplastic JJ cord-274510-fo7p98np 31 45 cells cell NNS cord-274510-fo7p98np 31 46 [ [ -LRB- cord-274510-fo7p98np 31 47 21 21 CD cord-274510-fo7p98np 31 48 ] ] -RRB- cord-274510-fo7p98np 31 49 [ [ -LRB- cord-274510-fo7p98np 31 50 22 22 CD cord-274510-fo7p98np 31 51 ] ] -RRB- cord-274510-fo7p98np 31 52 [ [ -LRB- cord-274510-fo7p98np 31 53 23 23 CD cord-274510-fo7p98np 31 54 ] ] -RRB- cord-274510-fo7p98np 31 55 . . . cord-274510-fo7p98np 32 1 Indeed indeed RB cord-274510-fo7p98np 32 2 , , , cord-274510-fo7p98np 32 3 flu flu NN cord-274510-fo7p98np 32 4 - - HYPH cord-274510-fo7p98np 32 5 like like JJ cord-274510-fo7p98np 32 6 symptoms symptom NNS cord-274510-fo7p98np 32 7 with with IN cord-274510-fo7p98np 32 8 serum serum NN cord-274510-fo7p98np 32 9 nagalase nagalase NN cord-274510-fo7p98np 32 10 activity activity NN cord-274510-fo7p98np 32 11 similar similar JJ cord-274510-fo7p98np 32 12 to to IN cord-274510-fo7p98np 32 13 the the DT cord-274510-fo7p98np 32 14 influenza influenza JJ cord-274510-fo7p98np 32 15 acute acute JJ cord-274510-fo7p98np 32 16 state state NN cord-274510-fo7p98np 32 17 were be VBD cord-274510-fo7p98np 32 18 reported report VBN cord-274510-fo7p98np 32 19 in in IN cord-274510-fo7p98np 32 20 the the DT cord-274510-fo7p98np 32 21 early early JJ cord-274510-fo7p98np 32 22 stage stage NN cord-274510-fo7p98np 32 23 of of IN cord-274510-fo7p98np 32 24 HIV HIV NNP cord-274510-fo7p98np 32 25 - - HYPH cord-274510-fo7p98np 32 26 infection infection NN cord-274510-fo7p98np 32 27 , , , cord-274510-fo7p98np 32 28 so so IN cord-274510-fo7p98np 32 29 that that IN cord-274510-fo7p98np 32 30 the the DT cord-274510-fo7p98np 32 31 serum serum NN cord-274510-fo7p98np 32 32 enzyme enzyme NN cord-274510-fo7p98np 32 33 activity activity NN cord-274510-fo7p98np 32 34 may may MD cord-274510-fo7p98np 32 35 be be VB cord-274510-fo7p98np 32 36 detectable detectable JJ cord-274510-fo7p98np 32 37 at at IN cord-274510-fo7p98np 32 38 all all DT cord-274510-fo7p98np 32 39 phases phase NNS cord-274510-fo7p98np 32 40 of of IN cord-274510-fo7p98np 32 41 HIV HIV NNP cord-274510-fo7p98np 32 42 - - HYPH cord-274510-fo7p98np 32 43 infection infection NN cord-274510-fo7p98np 32 44 [ [ -LRB- cord-274510-fo7p98np 32 45 14 14 CD cord-274510-fo7p98np 32 46 ] ] -RRB- cord-274510-fo7p98np 32 47 [ [ -LRB- cord-274510-fo7p98np 32 48 15 15 CD cord-274510-fo7p98np 32 49 ] ] -RRB- cord-274510-fo7p98np 32 50 . . . cord-274510-fo7p98np 33 1 Similarly similarly RB cord-274510-fo7p98np 33 2 , , , cord-274510-fo7p98np 33 3 most most JJS cord-274510-fo7p98np 33 4 COVID-19 covid-19 JJ cord-274510-fo7p98np 33 5 patients patient NNS cord-274510-fo7p98np 33 6 complained complain VBD cord-274510-fo7p98np 33 7 of of IN cord-274510-fo7p98np 33 8 flu flu NN cord-274510-fo7p98np 33 9 - - HYPH cord-274510-fo7p98np 33 10 like like JJ cord-274510-fo7p98np 33 11 symptoms symptom NNS cord-274510-fo7p98np 33 12 in in IN cord-274510-fo7p98np 33 13 the the DT cord-274510-fo7p98np 33 14 early early JJ cord-274510-fo7p98np 33 15 stages stage NNS cord-274510-fo7p98np 33 16 of of IN cord-274510-fo7p98np 33 17 the the DT cord-274510-fo7p98np 33 18 disease disease NN cord-274510-fo7p98np 33 19 [ [ -LRB- cord-274510-fo7p98np 33 20 2 2 CD cord-274510-fo7p98np 33 21 ] ] -RRB- cord-274510-fo7p98np 33 22 [ [ -LRB- cord-274510-fo7p98np 33 23 3 3 CD cord-274510-fo7p98np 33 24 ] ] -RRB- cord-274510-fo7p98np 33 25 [ [ -LRB- cord-274510-fo7p98np 33 26 4 4 CD cord-274510-fo7p98np 33 27 ] ] -RRB- cord-274510-fo7p98np 33 28 [ [ -LRB- cord-274510-fo7p98np 33 29 5 5 CD cord-274510-fo7p98np 33 30 ] ] -RRB- cord-274510-fo7p98np 33 31 . . . cord-274510-fo7p98np 34 1 It -PRON- PRP cord-274510-fo7p98np 34 2 is be VBZ cord-274510-fo7p98np 34 3 now now RB cord-274510-fo7p98np 34 4 well well RB cord-274510-fo7p98np 34 5 known know VBN cord-274510-fo7p98np 34 6 that that IN cord-274510-fo7p98np 34 7 DBP DBP NNP cord-274510-fo7p98np 34 8 Gc Gc NNP cord-274510-fo7p98np 34 9 - - HYPH cord-274510-fo7p98np 34 10 globulin globulin NNP cord-274510-fo7p98np 34 11 plays play VBZ cord-274510-fo7p98np 34 12 a a DT cord-274510-fo7p98np 34 13 crucial crucial JJ cord-274510-fo7p98np 34 14 role role NN cord-274510-fo7p98np 34 15 in in IN cord-274510-fo7p98np 34 16 immune immune JJ cord-274510-fo7p98np 34 17 system system NN cord-274510-fo7p98np 34 18 regulation regulation NN cord-274510-fo7p98np 34 19 as as IN cord-274510-fo7p98np 34 20 a a DT cord-274510-fo7p98np 34 21 primary primary JJ cord-274510-fo7p98np 34 22 defense defense NN cord-274510-fo7p98np 34 23 against against IN cord-274510-fo7p98np 34 24 infections infection NNS cord-274510-fo7p98np 34 25 [ [ -LRB- cord-274510-fo7p98np 34 26 14 14 CD cord-274510-fo7p98np 34 27 ] ] -RRB- cord-274510-fo7p98np 35 1 [ [ -LRB- cord-274510-fo7p98np 35 2 15 15 CD cord-274510-fo7p98np 35 3 ] ] -RRB- cord-274510-fo7p98np 35 4 [ [ -LRB- cord-274510-fo7p98np 35 5 16 16 CD cord-274510-fo7p98np 35 6 ] ] -RRB- cord-274510-fo7p98np 35 7 [ [ -LRB- cord-274510-fo7p98np 35 8 17 17 CD cord-274510-fo7p98np 35 9 ] ] -RRB- cord-274510-fo7p98np 35 10 [ [ -LRB- cord-274510-fo7p98np 35 11 18 18 CD cord-274510-fo7p98np 35 12 ] ] -RRB- cord-274510-fo7p98np 35 13 [ [ -LRB- cord-274510-fo7p98np 35 14 19 19 CD cord-274510-fo7p98np 35 15 ] ] -RRB- cord-274510-fo7p98np 35 16 [ [ -LRB- cord-274510-fo7p98np 35 17 20 20 CD cord-274510-fo7p98np 35 18 ] ] -RRB- cord-274510-fo7p98np 35 19 . . . cord-274510-fo7p98np 36 1 In in IN cord-274510-fo7p98np 36 2 addition addition NN cord-274510-fo7p98np 36 3 to to IN cord-274510-fo7p98np 36 4 the the DT cord-274510-fo7p98np 36 5 storage storage NN cord-274510-fo7p98np 36 6 and and CC cord-274510-fo7p98np 36 7 transport transport NN cord-274510-fo7p98np 36 8 of of IN cord-274510-fo7p98np 36 9 active active JJ cord-274510-fo7p98np 36 10 vitamin vitamin NN cord-274510-fo7p98np 36 11 D3 D3 NNP cord-274510-fo7p98np 36 12 , , , cord-274510-fo7p98np 36 13 GcMAF GcMAF NNP cord-274510-fo7p98np 36 14 's 's POS cord-274510-fo7p98np 36 15 effects effect NNS cord-274510-fo7p98np 36 16 include include VBP cord-274510-fo7p98np 36 17 macrophage macrophage NN cord-274510-fo7p98np 36 18 modulation modulation NN cord-274510-fo7p98np 36 19 , , , cord-274510-fo7p98np 36 20 osteoclast osteoclast NN cord-274510-fo7p98np 36 21 activation activation NN cord-274510-fo7p98np 36 22 , , , cord-274510-fo7p98np 36 23 facilitation facilitation NN cord-274510-fo7p98np 36 24 of of IN cord-274510-fo7p98np 36 25 neutrophil neutrophil NN cord-274510-fo7p98np 36 26 chemotaxis chemotaxis NN cord-274510-fo7p98np 36 27 mediated mediate VBN cord-274510-fo7p98np 36 28 by by IN cord-274510-fo7p98np 36 29 C5 C5 NNP cord-274510-fo7p98np 36 30 derived derive VBN cord-274510-fo7p98np 36 31 peptide peptide NN cord-274510-fo7p98np 36 32 , , , cord-274510-fo7p98np 36 33 superoxide superoxide NN cord-274510-fo7p98np 36 34 activity activity NN cord-274510-fo7p98np 36 35 , , , cord-274510-fo7p98np 36 36 scavenging scavenging NN cord-274510-fo7p98np 36 37 of of IN cord-274510-fo7p98np 36 38 circulating circulate VBG cord-274510-fo7p98np 36 39 G g NN cord-274510-fo7p98np 36 40 - - HYPH cord-274510-fo7p98np 36 41 actin actin NN cord-274510-fo7p98np 36 42 , , , cord-274510-fo7p98np 36 43 anti anti JJ cord-274510-fo7p98np 36 44 - - JJ cord-274510-fo7p98np 36 45 angiogenetic angiogenetic JJ cord-274510-fo7p98np 36 46 and and CC cord-274510-fo7p98np 36 47 anti anti JJ cord-274510-fo7p98np 36 48 - - JJ cord-274510-fo7p98np 36 49 tumor tumor JJ cord-274510-fo7p98np 36 50 properties property NNS cord-274510-fo7p98np 36 51 [ [ -LRB- cord-274510-fo7p98np 36 52 24 24 CD cord-274510-fo7p98np 36 53 ] ] -RRB- cord-274510-fo7p98np 36 54 [ [ -LRB- cord-274510-fo7p98np 36 55 25 25 CD cord-274510-fo7p98np 36 56 ] ] -RRB- cord-274510-fo7p98np 36 57 [ [ -LRB- cord-274510-fo7p98np 36 58 26 26 CD cord-274510-fo7p98np 36 59 ] ] -RRB- cord-274510-fo7p98np 36 60 [ [ -LRB- cord-274510-fo7p98np 36 61 27 27 CD cord-274510-fo7p98np 36 62 ] ] -RRB- cord-274510-fo7p98np 36 63 [ [ -LRB- cord-274510-fo7p98np 36 64 28 28 CD cord-274510-fo7p98np 36 65 ] ] -RRB- cord-274510-fo7p98np 36 66 . . . cord-274510-fo7p98np 37 1 Thus thus RB cord-274510-fo7p98np 37 2 , , , cord-274510-fo7p98np 37 3 this this DT cord-274510-fo7p98np 37 4 multifunctional multifunctional JJ cord-274510-fo7p98np 37 5 protein protein NN cord-274510-fo7p98np 37 6 , , , cord-274510-fo7p98np 37 7 released release VBN cord-274510-fo7p98np 37 8 into into IN cord-274510-fo7p98np 37 9 the the DT cord-274510-fo7p98np 37 10 blood blood NN cord-274510-fo7p98np 37 11 stream stream NN cord-274510-fo7p98np 37 12 , , , cord-274510-fo7p98np 37 13 acts act VBZ cord-274510-fo7p98np 37 14 as as IN cord-274510-fo7p98np 37 15 a a DT cord-274510-fo7p98np 37 16 systemic systemic JJ cord-274510-fo7p98np 37 17 immune immune JJ cord-274510-fo7p98np 37 18 modulator modulator NN cord-274510-fo7p98np 37 19 without without IN cord-274510-fo7p98np 37 20 pro pro JJ cord-274510-fo7p98np 37 21 - - JJ cord-274510-fo7p98np 37 22 inflammatory inflammatory JJ cord-274510-fo7p98np 37 23 activities activity NNS cord-274510-fo7p98np 37 24 . . . cord-274510-fo7p98np 38 1 This this DT cord-274510-fo7p98np 38 2 means mean VBZ cord-274510-fo7p98np 38 3 that that IN cord-274510-fo7p98np 38 4 any any DT cord-274510-fo7p98np 38 5 function function NN cord-274510-fo7p98np 38 6 impairment impairment NN cord-274510-fo7p98np 38 7 of of IN cord-274510-fo7p98np 38 8 Gc Gc NNP cord-274510-fo7p98np 38 9 - - HYPH cord-274510-fo7p98np 38 10 globulin globulin NN cord-274510-fo7p98np 38 11 could could MD cord-274510-fo7p98np 38 12 result result VB cord-274510-fo7p98np 38 13 in in IN cord-274510-fo7p98np 38 14 a a DT cord-274510-fo7p98np 38 15 state state NN cord-274510-fo7p98np 38 16 of of IN cord-274510-fo7p98np 38 17 both both DT cord-274510-fo7p98np 38 18 immunosuppression immunosuppression NN cord-274510-fo7p98np 38 19 and and CC cord-274510-fo7p98np 38 20 uncontrolled uncontrolled JJ cord-274510-fo7p98np 38 21 inflammation inflammation NN cord-274510-fo7p98np 38 22 , , , cord-274510-fo7p98np 38 23 just just RB cord-274510-fo7p98np 38 24 like like IN cord-274510-fo7p98np 38 25 in in IN cord-274510-fo7p98np 38 26 severe severe JJ cord-274510-fo7p98np 38 27 COVID-19 covid-19 NN cord-274510-fo7p98np 38 28 . . . cord-274510-fo7p98np 39 1 Interestingly interestingly RB cord-274510-fo7p98np 39 2 , , , cord-274510-fo7p98np 39 3 HIV HIV NNP cord-274510-fo7p98np 39 4 viremia viremia NN cord-274510-fo7p98np 39 5 was be VBD cord-274510-fo7p98np 39 6 associated associate VBN cord-274510-fo7p98np 39 7 with with IN cord-274510-fo7p98np 39 8 higher high JJR cord-274510-fo7p98np 39 9 level level NN cord-274510-fo7p98np 39 10 of of IN cord-274510-fo7p98np 39 11 biomarkers biomarker NNS cord-274510-fo7p98np 39 12 of of IN cord-274510-fo7p98np 39 13 inflammation inflammation NN cord-274510-fo7p98np 39 14 ( ( -LRB- cord-274510-fo7p98np 39 15 measured measure VBN cord-274510-fo7p98np 39 16 by by IN cord-274510-fo7p98np 39 17 IL-6 IL-6 NNP cord-274510-fo7p98np 39 18 ) ) -RRB- cord-274510-fo7p98np 39 19 , , , cord-274510-fo7p98np 39 20 monocyte monocyte NNP cord-274510-fo7p98np 39 21 activation activation NN cord-274510-fo7p98np 39 22 ( ( -LRB- cord-274510-fo7p98np 39 23 soluble soluble JJ cord-274510-fo7p98np 39 24 CD14 CD14 NNP cord-274510-fo7p98np 39 25 ) ) -RRB- cord-274510-fo7p98np 39 26 , , , cord-274510-fo7p98np 39 27 and and CC cord-274510-fo7p98np 39 28 coagulation coagulation NN cord-274510-fo7p98np 39 29 ( ( -LRB- cord-274510-fo7p98np 39 30 D d NN cord-274510-fo7p98np 39 31 - - HYPH cord-274510-fo7p98np 39 32 dimer dimer NN cord-274510-fo7p98np 39 33 ) ) -RRB- cord-274510-fo7p98np 39 34 , , , cord-274510-fo7p98np 39 35 leading lead VBG cord-274510-fo7p98np 39 36 to to IN cord-274510-fo7p98np 39 37 increased increase VBN cord-274510-fo7p98np 39 38 mortality mortality NN cord-274510-fo7p98np 39 39 , , , cord-274510-fo7p98np 39 40 as as IN cord-274510-fo7p98np 39 41 compared compare VBN cord-274510-fo7p98np 39 42 with with IN cord-274510-fo7p98np 39 43 uninfected uninfected JJ cord-274510-fo7p98np 39 44 people people NNS cord-274510-fo7p98np 39 45 [ [ -LRB- cord-274510-fo7p98np 39 46 29 29 CD cord-274510-fo7p98np 39 47 ] ] -RRB- cord-274510-fo7p98np 39 48 . . . cord-274510-fo7p98np 40 1 Meanwhile meanwhile RB cord-274510-fo7p98np 40 2 , , , cord-274510-fo7p98np 40 3 in in IN cord-274510-fo7p98np 40 4 COVID-19 covid-19 JJ cord-274510-fo7p98np 40 5 patients patient NNS cord-274510-fo7p98np 40 6 , , , cord-274510-fo7p98np 40 7 in in IN cord-274510-fo7p98np 40 8 addition addition NN cord-274510-fo7p98np 40 9 to to IN cord-274510-fo7p98np 40 10 the the DT cord-274510-fo7p98np 40 11 reduced reduce VBN cord-274510-fo7p98np 40 12 peripheral peripheral JJ cord-274510-fo7p98np 40 13 lymphocyte lymphocyte NN cord-274510-fo7p98np 40 14 counts count NNS cord-274510-fo7p98np 40 15 , , , cord-274510-fo7p98np 40 16 mainly mainly RB cord-274510-fo7p98np 40 17 CD4 CD4 NNP cord-274510-fo7p98np 40 18 + + CC cord-274510-fo7p98np 40 19 T T NNP cord-274510-fo7p98np 40 20 and and CC cord-274510-fo7p98np 40 21 CD8 CD8 NNP cord-274510-fo7p98np 40 22 + + CC cord-274510-fo7p98np 40 23 T T NNP cord-274510-fo7p98np 40 24 cells cell NNS cord-274510-fo7p98np 40 25 , , , cord-274510-fo7p98np 40 26 there there EX cord-274510-fo7p98np 40 27 were be VBD cord-274510-fo7p98np 40 28 found find VBN cord-274510-fo7p98np 40 29 significant significant JJ cord-274510-fo7p98np 40 30 high high JJ cord-274510-fo7p98np 40 31 levels level NNS cord-274510-fo7p98np 40 32 of of IN cord-274510-fo7p98np 40 33 pro pro JJ cord-274510-fo7p98np 40 34 - - JJ cord-274510-fo7p98np 40 35 inflammatory inflammatory JJ cord-274510-fo7p98np 40 36 cytokines cytokine NNS cord-274510-fo7p98np 40 37 and and CC cord-274510-fo7p98np 40 38 chemokines chemokine NNS cord-274510-fo7p98np 40 39 [ [ -LRB- cord-274510-fo7p98np 40 40 2 2 CD cord-274510-fo7p98np 40 41 ] ] -RRB- cord-274510-fo7p98np 40 42 [ [ -LRB- cord-274510-fo7p98np 40 43 3 3 CD cord-274510-fo7p98np 40 44 ] ] -RRB- cord-274510-fo7p98np 40 45 [ [ -LRB- cord-274510-fo7p98np 40 46 4 4 CD cord-274510-fo7p98np 40 47 ] ] -RRB- cord-274510-fo7p98np 40 48 [ [ -LRB- cord-274510-fo7p98np 40 49 5 5 CD cord-274510-fo7p98np 40 50 ] ] -RRB- cord-274510-fo7p98np 40 51 [ [ -LRB- cord-274510-fo7p98np 40 52 6 6 CD cord-274510-fo7p98np 40 53 ] ] -RRB- cord-274510-fo7p98np 40 54 [ [ -LRB- cord-274510-fo7p98np 40 55 7 7 CD cord-274510-fo7p98np 40 56 ] ] -RRB- cord-274510-fo7p98np 40 57 . . . cord-274510-fo7p98np 41 1 Indeed indeed RB cord-274510-fo7p98np 41 2 , , , cord-274510-fo7p98np 41 3 GcMAF GcMAF NNP cord-274510-fo7p98np 41 4 is be VBZ cord-274510-fo7p98np 41 5 not not RB cord-274510-fo7p98np 41 6 only only RB cord-274510-fo7p98np 41 7 a a DT cord-274510-fo7p98np 41 8 simple simple JJ cord-274510-fo7p98np 41 9 potent potent JJ cord-274510-fo7p98np 41 10 activator activator NN cord-274510-fo7p98np 41 11 for for IN cord-274510-fo7p98np 41 12 macrophages macrophage NNS cord-274510-fo7p98np 41 13 , , , cord-274510-fo7p98np 41 14 but but CC cord-274510-fo7p98np 41 15 more more RBR cord-274510-fo7p98np 41 16 specifically specifically RB cord-274510-fo7p98np 41 17 is be VBZ cord-274510-fo7p98np 41 18 able able JJ cord-274510-fo7p98np 41 19 to to TO cord-274510-fo7p98np 41 20 turn turn VB cord-274510-fo7p98np 41 21 macrophage macrophage NN cord-274510-fo7p98np 41 22 activity activity NN cord-274510-fo7p98np 41 23 on on IN cord-274510-fo7p98np 41 24 at at IN cord-274510-fo7p98np 41 25 the the DT cord-274510-fo7p98np 41 26 sites site NNS cord-274510-fo7p98np 41 27 of of IN cord-274510-fo7p98np 41 28 infection infection NN cord-274510-fo7p98np 41 29 / / SYM cord-274510-fo7p98np 41 30 inflammation inflammation NN cord-274510-fo7p98np 41 31 and and CC cord-274510-fo7p98np 41 32 then then RB cord-274510-fo7p98np 41 33 to to TO cord-274510-fo7p98np 41 34 induce induce VB cord-274510-fo7p98np 41 35 their -PRON- PRP$ cord-274510-fo7p98np 41 36 apoptosis apoptosis NN cord-274510-fo7p98np 41 37 by by IN cord-274510-fo7p98np 41 38 upregulating upregulate VBG cord-274510-fo7p98np 41 39 caspase caspase NN cord-274510-fo7p98np 41 40 activity activity NN cord-274510-fo7p98np 41 41 via via IN cord-274510-fo7p98np 41 42 the the DT cord-274510-fo7p98np 41 43 p38 p38 NN cord-274510-fo7p98np 41 44 and and CC cord-274510-fo7p98np 41 45 JNK1/2 JNK1/2 NNP cord-274510-fo7p98np 41 46 pathways pathway NNS cord-274510-fo7p98np 41 47 when when WRB cord-274510-fo7p98np 41 48 no no RB cord-274510-fo7p98np 41 49 longer long RBR cord-274510-fo7p98np 41 50 needed need VBD cord-274510-fo7p98np 41 51 [ [ -LRB- cord-274510-fo7p98np 41 52 30 30 CD cord-274510-fo7p98np 41 53 ] ] -RRB- cord-274510-fo7p98np 41 54 . . . cord-274510-fo7p98np 42 1 Post post JJ cord-274510-fo7p98np 42 2 - - JJ cord-274510-fo7p98np 42 3 mortem mortem JJ cord-274510-fo7p98np 42 4 lung lung NN cord-274510-fo7p98np 42 5 observations observation NNS cord-274510-fo7p98np 42 6 of of IN cord-274510-fo7p98np 42 7 patients patient NNS cord-274510-fo7p98np 42 8 died die VBD cord-274510-fo7p98np 42 9 of of IN cord-274510-fo7p98np 42 10 COVID-19 COVID-19 NNP cord-274510-fo7p98np 42 11 showed show VBD cord-274510-fo7p98np 42 12 the the DT cord-274510-fo7p98np 42 13 presence presence NN cord-274510-fo7p98np 42 14 of of IN cord-274510-fo7p98np 42 15 mononuclear mononuclear NN cord-274510-fo7p98np 42 16 cells cell NNS cord-274510-fo7p98np 42 17 and and CC cord-274510-fo7p98np 42 18 macrophages macrophage NNS cord-274510-fo7p98np 42 19 infiltrating infiltrate VBG cord-274510-fo7p98np 42 20 air air NN cord-274510-fo7p98np 42 21 spaces space NNS cord-274510-fo7p98np 42 22 by by IN cord-274510-fo7p98np 42 23 autopsy autopsy JJ cord-274510-fo7p98np 42 24 [ [ -LRB- cord-274510-fo7p98np 42 25 9 9 CD cord-274510-fo7p98np 42 26 ] ] -RRB- cord-274510-fo7p98np 42 27 [ [ -LRB- cord-274510-fo7p98np 42 28 10 10 CD cord-274510-fo7p98np 42 29 ] ] -RRB- cord-274510-fo7p98np 42 30 [ [ -LRB- cord-274510-fo7p98np 42 31 11 11 CD cord-274510-fo7p98np 42 32 ] ] -RRB- cord-274510-fo7p98np 42 33 [ [ -LRB- cord-274510-fo7p98np 42 34 12 12 CD cord-274510-fo7p98np 42 35 ] ] -RRB- cord-274510-fo7p98np 42 36 . . . cord-274510-fo7p98np 43 1 With with IN cord-274510-fo7p98np 43 2 regards regard NNS cord-274510-fo7p98np 43 3 to to IN cord-274510-fo7p98np 43 4 the the DT cord-274510-fo7p98np 43 5 anti anti JJ cord-274510-fo7p98np 43 6 - - JJ cord-274510-fo7p98np 43 7 oxidant oxidant JJ cord-274510-fo7p98np 43 8 properties property NNS cord-274510-fo7p98np 43 9 , , , cord-274510-fo7p98np 43 10 it -PRON- PRP cord-274510-fo7p98np 43 11 was be VBD cord-274510-fo7p98np 43 12 assessed assess VBN cord-274510-fo7p98np 43 13 that that IN cord-274510-fo7p98np 43 14 GcMAF GcMAF NNP cord-274510-fo7p98np 43 15 promotes promote VBZ cord-274510-fo7p98np 43 16 the the DT cord-274510-fo7p98np 43 17 superoxide superoxide NN cord-274510-fo7p98np 43 18 generating generating NN cord-274510-fo7p98np 43 19 capacity capacity NN cord-274510-fo7p98np 43 20 of of IN cord-274510-fo7p98np 43 21 activated activate VBN cord-274510-fo7p98np 43 22 macrophages macrophage NNS cord-274510-fo7p98np 43 23 and and CC cord-274510-fo7p98np 43 24 the the DT cord-274510-fo7p98np 43 25 production production NN cord-274510-fo7p98np 43 26 of of IN cord-274510-fo7p98np 43 27 nitric nitric NN cord-274510-fo7p98np 43 28 oxide oxide NN cord-274510-fo7p98np 43 29 ( ( -LRB- cord-274510-fo7p98np 43 30 NO no RB cord-274510-fo7p98np 43 31 ) ) -RRB- cord-274510-fo7p98np 43 32 [ [ -LRB- cord-274510-fo7p98np 43 33 31 31 CD cord-274510-fo7p98np 43 34 ] ] -RRB- cord-274510-fo7p98np 43 35 . . . cord-274510-fo7p98np 44 1 An an DT cord-274510-fo7p98np 44 2 article article NN cord-274510-fo7p98np 44 3 by by IN cord-274510-fo7p98np 44 4 Nozik Nozik NNP cord-274510-fo7p98np 44 5 - - HYPH cord-274510-fo7p98np 44 6 Grayck Grayck NNP cord-274510-fo7p98np 44 7 et et FW cord-274510-fo7p98np 44 8 al al NNP cord-274510-fo7p98np 44 9 . . . cord-274510-fo7p98np 45 1 [ [ -LRB- cord-274510-fo7p98np 45 2 32 32 CD cord-274510-fo7p98np 45 3 ] ] -RRB- cord-274510-fo7p98np 45 4 pertinently pertinently RB cord-274510-fo7p98np 45 5 and and CC cord-274510-fo7p98np 45 6 interestingly interestingly RB cord-274510-fo7p98np 45 7 showed show VBD cord-274510-fo7p98np 45 8 that that IN cord-274510-fo7p98np 45 9 the the DT cord-274510-fo7p98np 45 10 expression expression NN cord-274510-fo7p98np 45 11 of of IN cord-274510-fo7p98np 45 12 extracellular extracellular JJ cord-274510-fo7p98np 45 13 superoxide superoxide NN cord-274510-fo7p98np 45 14 dismutase dismutase NN cord-274510-fo7p98np 45 15 ( ( -LRB- cord-274510-fo7p98np 45 16 EC EC NNP cord-274510-fo7p98np 45 17 - - HYPH cord-274510-fo7p98np 45 18 SOD SOD NNP cord-274510-fo7p98np 45 19 ) ) -RRB- cord-274510-fo7p98np 45 20 mRNA mrna NN cord-274510-fo7p98np 45 21 and and CC cord-274510-fo7p98np 45 22 protein protein NN cord-274510-fo7p98np 45 23 is be VBZ cord-274510-fo7p98np 45 24 cell cell NN cord-274510-fo7p98np 45 25 - - HYPH cord-274510-fo7p98np 45 26 and and CC cord-274510-fo7p98np 45 27 tissue tissue NN cord-274510-fo7p98np 45 28 - - HYPH cord-274510-fo7p98np 45 29 specific specific JJ cord-274510-fo7p98np 45 30 and and CC cord-274510-fo7p98np 45 31 is be VBZ cord-274510-fo7p98np 45 32 prominent prominent JJ cord-274510-fo7p98np 45 33 in in IN cord-274510-fo7p98np 45 34 lung lung NN cord-274510-fo7p98np 45 35 , , , cord-274510-fo7p98np 45 36 heart heart NN cord-274510-fo7p98np 45 37 , , , cord-274510-fo7p98np 45 38 blood blood NN cord-274510-fo7p98np 45 39 vessels vessel NNS cord-274510-fo7p98np 45 40 , , , cord-274510-fo7p98np 45 41 placenta placenta NN cord-274510-fo7p98np 45 42 and and CC cord-274510-fo7p98np 45 43 kidney kidney NN cord-274510-fo7p98np 45 44 . . . cord-274510-fo7p98np 46 1 In in IN cord-274510-fo7p98np 46 2 particular particular JJ cord-274510-fo7p98np 46 3 , , , cord-274510-fo7p98np 46 4 high high JJ cord-274510-fo7p98np 46 5 levels level NNS cord-274510-fo7p98np 46 6 of of IN cord-274510-fo7p98np 46 7 EC EC NNP cord-274510-fo7p98np 46 8 - - HYPH cord-274510-fo7p98np 46 9 SOD SOD NNP cord-274510-fo7p98np 46 10 are be VBP cord-274510-fo7p98np 46 11 present present JJ cord-274510-fo7p98np 46 12 in in IN cord-274510-fo7p98np 46 13 lung lung NN cord-274510-fo7p98np 46 14 macrophages macrophage NNS cord-274510-fo7p98np 46 15 , , , cord-274510-fo7p98np 46 16 alveolar alveolar NN cord-274510-fo7p98np 46 17 type type NN cord-274510-fo7p98np 46 18 II ii CD cord-274510-fo7p98np 46 19 cells cell NNS cord-274510-fo7p98np 46 20 , , , cord-274510-fo7p98np 46 21 fibroblasts fibroblast NNS cord-274510-fo7p98np 46 22 , , , cord-274510-fo7p98np 46 23 vascular vascular JJ cord-274510-fo7p98np 46 24 smooth smooth JJ cord-274510-fo7p98np 46 25 muscle muscle NN cord-274510-fo7p98np 46 26 cells cell NNS cord-274510-fo7p98np 46 27 , , , cord-274510-fo7p98np 46 28 and and CC cord-274510-fo7p98np 46 29 endothelial endothelial JJ cord-274510-fo7p98np 46 30 cells cell NNS cord-274510-fo7p98np 46 31 . . . cord-274510-fo7p98np 47 1 EC EC NNP cord-274510-fo7p98np 47 2 - - HYPH cord-274510-fo7p98np 47 3 SOD SOD NNP cord-274510-fo7p98np 47 4 limits limit VBZ cord-274510-fo7p98np 47 5 oxidative oxidative JJ cord-274510-fo7p98np 47 6 stress stress NN cord-274510-fo7p98np 47 7 and and CC cord-274510-fo7p98np 47 8 preserves preserve VBZ cord-274510-fo7p98np 47 9 NO no DT cord-274510-fo7p98np 47 10 bioactivity bioactivity NN cord-274510-fo7p98np 47 11 , , , cord-274510-fo7p98np 47 12 thus thus RB cord-274510-fo7p98np 47 13 protecting protect VBG cord-274510-fo7p98np 47 14 against against IN cord-274510-fo7p98np 47 15 a a DT cord-274510-fo7p98np 47 16 number number NN cord-274510-fo7p98np 47 17 of of IN cord-274510-fo7p98np 47 18 lung lung NN cord-274510-fo7p98np 47 19 and and CC cord-274510-fo7p98np 47 20 cardiovascular cardiovascular JJ cord-274510-fo7p98np 47 21 diseases disease NNS cord-274510-fo7p98np 47 22 [ [ -LRB- cord-274510-fo7p98np 47 23 32 32 CD cord-274510-fo7p98np 47 24 ] ] -RRB- cord-274510-fo7p98np 47 25 . . . cord-274510-fo7p98np 48 1 Even even RB cord-274510-fo7p98np 48 2 though though IN cord-274510-fo7p98np 48 3 only only RB cord-274510-fo7p98np 48 4 in in IN cord-274510-fo7p98np 48 5 a a DT cord-274510-fo7p98np 48 6 minority minority NN cord-274510-fo7p98np 48 7 of of IN cord-274510-fo7p98np 48 8 cases case NNS cord-274510-fo7p98np 48 9 , , , cord-274510-fo7p98np 48 10 COVID-19 COVID-19 NNP cord-274510-fo7p98np 48 11 may may MD cord-274510-fo7p98np 48 12 progress progress VB cord-274510-fo7p98np 48 13 to to IN cord-274510-fo7p98np 48 14 life life NN cord-274510-fo7p98np 48 15 - - HYPH cord-274510-fo7p98np 48 16 threatening threaten VBG cord-274510-fo7p98np 48 17 complications complication NNS cord-274510-fo7p98np 48 18 , , , cord-274510-fo7p98np 48 19 including include VBG cord-274510-fo7p98np 48 20 respiratory respiratory JJ cord-274510-fo7p98np 48 21 failure failure NN cord-274510-fo7p98np 48 22 , , , cord-274510-fo7p98np 48 23 acute acute JJ cord-274510-fo7p98np 48 24 cardiac cardiac JJ cord-274510-fo7p98np 48 25 injury injury NN cord-274510-fo7p98np 48 26 , , , cord-274510-fo7p98np 48 27 acute acute JJ cord-274510-fo7p98np 48 28 kidney kidney NN cord-274510-fo7p98np 48 29 injury injury NN cord-274510-fo7p98np 48 30 , , , cord-274510-fo7p98np 48 31 septic septic JJ cord-274510-fo7p98np 48 32 shock shock NN cord-274510-fo7p98np 48 33 , , , cord-274510-fo7p98np 48 34 disseminated disseminate VBN cord-274510-fo7p98np 48 35 intra intra JJ cord-274510-fo7p98np 48 36 - - JJ cord-274510-fo7p98np 48 37 vascular vascular JJ cord-274510-fo7p98np 48 38 coagulation coagulation NN cord-274510-fo7p98np 48 39 ( ( -LRB- cord-274510-fo7p98np 48 40 DIC DIC NNP cord-274510-fo7p98np 48 41 ) ) -RRB- cord-274510-fo7p98np 48 42 , , , cord-274510-fo7p98np 48 43 and and CC cord-274510-fo7p98np 48 44 multi multi JJ cord-274510-fo7p98np 48 45 - - JJ cord-274510-fo7p98np 48 46 organ organ JJ cord-274510-fo7p98np 48 47 dysfunction dysfunction NN cord-274510-fo7p98np 48 48 [ [ -LRB- cord-274510-fo7p98np 48 49 2 2 CD cord-274510-fo7p98np 48 50 ] ] -RRB- cord-274510-fo7p98np 48 51 [ [ -LRB- cord-274510-fo7p98np 48 52 3 3 CD cord-274510-fo7p98np 48 53 ] ] -RRB- cord-274510-fo7p98np 48 54 [ [ -LRB- cord-274510-fo7p98np 48 55 4 4 CD cord-274510-fo7p98np 48 56 ] ] -RRB- cord-274510-fo7p98np 48 57 [ [ -LRB- cord-274510-fo7p98np 48 58 5 5 CD cord-274510-fo7p98np 48 59 ] ] -RRB- cord-274510-fo7p98np 48 60 . . . cord-274510-fo7p98np 49 1 Hypoxemia Hypoxemia NNP cord-274510-fo7p98np 49 2 was be VBD cord-274510-fo7p98np 49 3 found find VBN cord-274510-fo7p98np 49 4 to to TO cord-274510-fo7p98np 49 5 be be VB cord-274510-fo7p98np 49 6 associated associate VBN cord-274510-fo7p98np 49 7 with with IN cord-274510-fo7p98np 49 8 interstitial interstitial JJ cord-274510-fo7p98np 49 9 pneumonia pneumonia NN cord-274510-fo7p98np 49 10 and and CC cord-274510-fo7p98np 49 11 , , , cord-274510-fo7p98np 49 12 in in IN cord-274510-fo7p98np 49 13 10 10 CD cord-274510-fo7p98np 49 14 % % NN cord-274510-fo7p98np 49 15 to to TO cord-274510-fo7p98np 49 16 20 20 CD cord-274510-fo7p98np 49 17 % % NN cord-274510-fo7p98np 49 18 of of IN cord-274510-fo7p98np 49 19 cases case NNS cord-274510-fo7p98np 49 20 , , , cord-274510-fo7p98np 49 21 developed develop VBN cord-274510-fo7p98np 49 22 into into IN cord-274510-fo7p98np 49 23 acute acute JJ cord-274510-fo7p98np 49 24 respiratory respiratory JJ cord-274510-fo7p98np 49 25 distress distress NN cord-274510-fo7p98np 49 26 syndrome syndrome NN cord-274510-fo7p98np 49 27 ( ( -LRB- cord-274510-fo7p98np 49 28 ARDS ARDS NNP cord-274510-fo7p98np 49 29 ) ) -RRB- cord-274510-fo7p98np 49 30 [ [ -LRB- cord-274510-fo7p98np 49 31 2 2 LS cord-274510-fo7p98np 49 32 ] ] -RRB- cord-274510-fo7p98np 49 33 [ [ -LRB- cord-274510-fo7p98np 49 34 3 3 CD cord-274510-fo7p98np 49 35 ] ] -RRB- cord-274510-fo7p98np 49 36 [ [ -LRB- cord-274510-fo7p98np 49 37 4 4 CD cord-274510-fo7p98np 49 38 ] ] -RRB- cord-274510-fo7p98np 49 39 [ [ -LRB- cord-274510-fo7p98np 49 40 5 5 CD cord-274510-fo7p98np 49 41 ] ] -RRB- cord-274510-fo7p98np 49 42 . . . cord-274510-fo7p98np 50 1 In in IN cord-274510-fo7p98np 50 2 this this DT cord-274510-fo7p98np 50 3 connection connection NN cord-274510-fo7p98np 50 4 , , , cord-274510-fo7p98np 50 5 it -PRON- PRP cord-274510-fo7p98np 50 6 was be VBD cord-274510-fo7p98np 50 7 documented document VBN cord-274510-fo7p98np 50 8 that that IN cord-274510-fo7p98np 50 9 ARDS ARDS NNP cord-274510-fo7p98np 50 10 as as RB cord-274510-fo7p98np 50 11 well well RB cord-274510-fo7p98np 50 12 as as IN cord-274510-fo7p98np 50 13 organ organ NN cord-274510-fo7p98np 50 14 dysfunction dysfunction NN cord-274510-fo7p98np 50 15 and and CC cord-274510-fo7p98np 50 16 septic septic JJ cord-274510-fo7p98np 50 17 shock shock NN cord-274510-fo7p98np 50 18 is be VBZ cord-274510-fo7p98np 50 19 characterized characterize VBN cord-274510-fo7p98np 50 20 by by IN cord-274510-fo7p98np 50 21 actin actin NN cord-274510-fo7p98np 50 22 release release NN cord-274510-fo7p98np 50 23 which which WDT cord-274510-fo7p98np 50 24 is be VBZ cord-274510-fo7p98np 50 25 involved involve VBN cord-274510-fo7p98np 50 26 in in IN cord-274510-fo7p98np 50 27 microvascular microvascular JJ cord-274510-fo7p98np 50 28 impairment impairment NN cord-274510-fo7p98np 50 29 [ [ -LRB- cord-274510-fo7p98np 50 30 33 33 CD cord-274510-fo7p98np 50 31 ] ] -RRB- cord-274510-fo7p98np 50 32 [ [ -LRB- cord-274510-fo7p98np 50 33 34 34 CD cord-274510-fo7p98np 50 34 ] ] -RRB- cord-274510-fo7p98np 50 35 . . . cord-274510-fo7p98np 51 1 DBP DBP NNP cord-274510-fo7p98np 51 2 has have VBZ cord-274510-fo7p98np 51 3 an an DT cord-274510-fo7p98np 51 4 additional additional JJ cord-274510-fo7p98np 51 5 function function NN cord-274510-fo7p98np 51 6 in in IN cord-274510-fo7p98np 51 7 binding bind VBG cord-274510-fo7p98np 51 8 monomeric monomeric JJ cord-274510-fo7p98np 51 9 globular globular JJ cord-274510-fo7p98np 51 10 ( ( -LRB- cord-274510-fo7p98np 51 11 G)-actin G)-actin NNP cord-274510-fo7p98np 51 12 with with IN cord-274510-fo7p98np 51 13 high high JJ cord-274510-fo7p98np 51 14 affinity affinity NN cord-274510-fo7p98np 51 15 . . . cord-274510-fo7p98np 52 1 Thereby thereby RB cord-274510-fo7p98np 52 2 , , , cord-274510-fo7p98np 52 3 rapidly rapidly RB cord-274510-fo7p98np 52 4 removing remove VBG cord-274510-fo7p98np 52 5 polymeric polymeric JJ cord-274510-fo7p98np 52 6 actin actin NN cord-274510-fo7p98np 52 7 fibrils fibril NNS cord-274510-fo7p98np 52 8 from from IN cord-274510-fo7p98np 52 9 the the DT cord-274510-fo7p98np 52 10 blood blood NN cord-274510-fo7p98np 52 11 stream stream NN cord-274510-fo7p98np 52 12 , , , cord-274510-fo7p98np 52 13 it -PRON- PRP cord-274510-fo7p98np 52 14 prevents prevent VBZ cord-274510-fo7p98np 52 15 actin actin NN cord-274510-fo7p98np 52 16 polymers polymer NNS cord-274510-fo7p98np 52 17 from from IN cord-274510-fo7p98np 52 18 clogging clog VBG cord-274510-fo7p98np 52 19 the the DT cord-274510-fo7p98np 52 20 micro micro JJ cord-274510-fo7p98np 52 21 vessels vessel NNS cord-274510-fo7p98np 52 22 not not RB cord-274510-fo7p98np 52 23 unlike unlike IN cord-274510-fo7p98np 52 24 fibrinogen fibrinogen NN cord-274510-fo7p98np 52 25 / / SYM cord-274510-fo7p98np 52 26 fibrin fibrin NN cord-274510-fo7p98np 52 27 and and CC cord-274510-fo7p98np 52 28 consequently consequently RB cord-274510-fo7p98np 52 29 platelet platelet NN cord-274510-fo7p98np 52 30 aggregation aggregation NN cord-274510-fo7p98np 52 31 and and CC cord-274510-fo7p98np 52 32 micro micro NNP cord-274510-fo7p98np 52 33 thrombi thrombi NNP cord-274510-fo7p98np 52 34 formation formation NN cord-274510-fo7p98np 52 35 [ [ -LRB- cord-274510-fo7p98np 52 36 35 35 CD cord-274510-fo7p98np 52 37 ] ] -RRB- cord-274510-fo7p98np 52 38 [ [ -LRB- cord-274510-fo7p98np 52 39 36 36 CD cord-274510-fo7p98np 52 40 ] ] -RRB- cord-274510-fo7p98np 52 41 . . . cord-274510-fo7p98np 53 1 What what WP cord-274510-fo7p98np 53 2 we -PRON- PRP cord-274510-fo7p98np 53 3 postulated postulate VBD cord-274510-fo7p98np 53 4 could could MD cord-274510-fo7p98np 53 5 also also RB cord-274510-fo7p98np 53 6 explain explain VB cord-274510-fo7p98np 53 7 hypercoagulability hypercoagulability NN cord-274510-fo7p98np 53 8 with with IN cord-274510-fo7p98np 53 9 elevated elevated JJ cord-274510-fo7p98np 53 10 concentrations concentration NNS cord-274510-fo7p98np 53 11 of of IN cord-274510-fo7p98np 53 12 D d NN cord-274510-fo7p98np 53 13 - - HYPH cord-274510-fo7p98np 53 14 dimer dimer NN cord-274510-fo7p98np 53 15 , , , cord-274510-fo7p98np 53 16 fibrin fibrin NN cord-274510-fo7p98np 53 17 degradation degradation NN cord-274510-fo7p98np 53 18 products product NNS cord-274510-fo7p98np 53 19 increase increase NN cord-274510-fo7p98np 53 20 , , , cord-274510-fo7p98np 53 21 PT pt NN cord-274510-fo7p98np 53 22 and and CC cord-274510-fo7p98np 53 23 aPTT aptt CD cord-274510-fo7p98np 53 24 prolongation prolongation NN cord-274510-fo7p98np 53 25 , , , cord-274510-fo7p98np 53 26 observed observe VBD cord-274510-fo7p98np 53 27 in in IN cord-274510-fo7p98np 53 28 COVID-19 covid-19 JJ cord-274510-fo7p98np 53 29 patients patient NNS cord-274510-fo7p98np 53 30 [ [ -LRB- cord-274510-fo7p98np 53 31 37 37 CD cord-274510-fo7p98np 53 32 ] ] -RRB- cord-274510-fo7p98np 53 33 [ [ -LRB- cord-274510-fo7p98np 53 34 38 38 CD cord-274510-fo7p98np 53 35 ] ] -RRB- cord-274510-fo7p98np 53 36 . . . cord-274510-fo7p98np 54 1 Tang Tang NNP cord-274510-fo7p98np 54 2 N N NNP cord-274510-fo7p98np 54 3 et et NNP cord-274510-fo7p98np 54 4 al al NNP cord-274510-fo7p98np 54 5 . . . cord-274510-fo7p98np 55 1 [ [ -LRB- cord-274510-fo7p98np 55 2 38 38 CD cord-274510-fo7p98np 55 3 ] ] -RRB- cord-274510-fo7p98np 55 4 reported report VBD cord-274510-fo7p98np 55 5 that that IN cord-274510-fo7p98np 55 6 71.4 71.4 CD cord-274510-fo7p98np 55 7 % % NN cord-274510-fo7p98np 55 8 of of IN cord-274510-fo7p98np 55 9 the the DT cord-274510-fo7p98np 55 10 non non JJ cord-274510-fo7p98np 55 11 survivors survivor NNS cord-274510-fo7p98np 55 12 of of IN cord-274510-fo7p98np 55 13 COVID-19 COVID-19 NNP cord-274510-fo7p98np 55 14 matched match VBD cord-274510-fo7p98np 55 15 the the DT cord-274510-fo7p98np 55 16 grade grade NN cord-274510-fo7p98np 55 17 of of IN cord-274510-fo7p98np 55 18 overt overt JJ cord-274510-fo7p98np 55 19 - - HYPH cord-274510-fo7p98np 55 20 DIC DIC NNP cord-274510-fo7p98np 55 21 according accord VBG cord-274510-fo7p98np 55 22 to to IN cord-274510-fo7p98np 55 23 the the DT cord-274510-fo7p98np 55 24 International International NNP cord-274510-fo7p98np 55 25 Society Society NNP cord-274510-fo7p98np 55 26 on on IN cord-274510-fo7p98np 55 27 Thrombosis Thrombosis NNP cord-274510-fo7p98np 55 28 and and CC cord-274510-fo7p98np 55 29 Haemostasis Haemostasis NNP cord-274510-fo7p98np 55 30 ( ( -LRB- cord-274510-fo7p98np 55 31 ISTH ISTH NNP cord-274510-fo7p98np 55 32 ) ) -RRB- cord-274510-fo7p98np 55 33 diagnostic diagnostic JJ cord-274510-fo7p98np 55 34 criteria criterion NNS cord-274510-fo7p98np 55 35 for for IN cord-274510-fo7p98np 55 36 DIC DIC NNP cord-274510-fo7p98np 55 37 . . . cord-274510-fo7p98np 56 1 Murine murine JJ cord-274510-fo7p98np 56 2 models model NNS cord-274510-fo7p98np 56 3 deficient deficient JJ cord-274510-fo7p98np 56 4 in in IN cord-274510-fo7p98np 56 5 DBP DBP NNP cord-274510-fo7p98np 56 6 showed show VBD cord-274510-fo7p98np 56 7 lung lung NN cord-274510-fo7p98np 56 8 damage damage NN cord-274510-fo7p98np 56 9 caused cause VBN cord-274510-fo7p98np 56 10 by by IN cord-274510-fo7p98np 56 11 actin actin NN cord-274510-fo7p98np 56 12 polymerization polymerization NN cord-274510-fo7p98np 56 13 , , , cord-274510-fo7p98np 56 14 developing develop VBG cord-274510-fo7p98np 56 15 severe severe JJ cord-274510-fo7p98np 56 16 acute acute JJ cord-274510-fo7p98np 56 17 lung lung NN cord-274510-fo7p98np 56 18 inflammation inflammation NN cord-274510-fo7p98np 56 19 with with IN cord-274510-fo7p98np 56 20 vascular vascular JJ cord-274510-fo7p98np 56 21 leakage leakage NN cord-274510-fo7p98np 56 22 , , , cord-274510-fo7p98np 56 23 hemorrhage hemorrhage NN cord-274510-fo7p98np 56 24 and and CC cord-274510-fo7p98np 56 25 thickening thickening NN cord-274510-fo7p98np 56 26 of of IN cord-274510-fo7p98np 56 27 the the DT cord-274510-fo7p98np 56 28 vascular vascular JJ cord-274510-fo7p98np 56 29 wall wall NN cord-274510-fo7p98np 56 30 after after IN cord-274510-fo7p98np 56 31 actin actin NN cord-274510-fo7p98np 56 32 injection injection NN cord-274510-fo7p98np 56 33 [ [ -LRB- cord-274510-fo7p98np 56 34 39 39 CD cord-274510-fo7p98np 56 35 ] ] -RRB- cord-274510-fo7p98np 56 36 . . . cord-274510-fo7p98np 57 1 Interestingly interestingly RB cord-274510-fo7p98np 57 2 , , , cord-274510-fo7p98np 57 3 the the DT cord-274510-fo7p98np 57 4 lung lung NN cord-274510-fo7p98np 57 5 was be VBD cord-274510-fo7p98np 57 6 the the DT cord-274510-fo7p98np 57 7 only only JJ cord-274510-fo7p98np 57 8 organ organ NN cord-274510-fo7p98np 57 9 that that WDT cord-274510-fo7p98np 57 10 showed show VBD cord-274510-fo7p98np 57 11 inflammatory inflammatory JJ cord-274510-fo7p98np 57 12 injury injury NN cord-274510-fo7p98np 57 13 after after IN cord-274510-fo7p98np 57 14 intravenous intravenous JJ cord-274510-fo7p98np 57 15 actin actin NN cord-274510-fo7p98np 57 16 injection injection NN cord-274510-fo7p98np 57 17 . . . cord-274510-fo7p98np 58 1 The the DT cord-274510-fo7p98np 58 2 observed observed JJ cord-274510-fo7p98np 58 3 lung lung NN cord-274510-fo7p98np 58 4 inflammation inflammation NN cord-274510-fo7p98np 58 5 was be VBD cord-274510-fo7p98np 58 6 consistent consistent JJ cord-274510-fo7p98np 58 7 with with IN cord-274510-fo7p98np 58 8 alterations alteration NNS cord-274510-fo7p98np 58 9 to to IN cord-274510-fo7p98np 58 10 lung lung NN cord-274510-fo7p98np 58 11 microvascular microvascular JJ cord-274510-fo7p98np 58 12 endothelial endothelial JJ cord-274510-fo7p98np 58 13 cells cell NNS cord-274510-fo7p98np 58 14 . . . cord-274510-fo7p98np 59 1 Indeed indeed RB cord-274510-fo7p98np 59 2 , , , cord-274510-fo7p98np 59 3 when when WRB cord-274510-fo7p98np 59 4 lung lung NN cord-274510-fo7p98np 59 5 endothelial endothelial NN cord-274510-fo7p98np 59 6 cells cell NNS cord-274510-fo7p98np 59 7 were be VBD cord-274510-fo7p98np 59 8 exposed expose VBN cord-274510-fo7p98np 59 9 to to IN cord-274510-fo7p98np 59 10 DBP dbp NN cord-274510-fo7p98np 59 11 - - HYPH cord-274510-fo7p98np 59 12 actin actin NN cord-274510-fo7p98np 59 13 complexes complex NNS cord-274510-fo7p98np 59 14 in in IN cord-274510-fo7p98np 59 15 vitro vitro FW cord-274510-fo7p98np 59 16 showed show VBD cord-274510-fo7p98np 59 17 enhanced enhanced JJ cord-274510-fo7p98np 59 18 cell cell NN cord-274510-fo7p98np 59 19 death death NN cord-274510-fo7p98np 59 20 [ [ -LRB- cord-274510-fo7p98np 59 21 39 39 CD cord-274510-fo7p98np 59 22 ] ] -RRB- cord-274510-fo7p98np 59 23 . . . cord-274510-fo7p98np 60 1 Reduced reduced JJ cord-274510-fo7p98np 60 2 levels level NNS cord-274510-fo7p98np 60 3 of of IN cord-274510-fo7p98np 60 4 DBP DBP NNP cord-274510-fo7p98np 60 5 were be VBD cord-274510-fo7p98np 60 6 even even RB cord-274510-fo7p98np 60 7 observed observe VBN cord-274510-fo7p98np 60 8 in in IN cord-274510-fo7p98np 60 9 sepsis sepsis NN cord-274510-fo7p98np 60 10 and and CC cord-274510-fo7p98np 60 11 organ organ NN cord-274510-fo7p98np 60 12 dysfunction dysfunction NN cord-274510-fo7p98np 60 13 of of IN cord-274510-fo7p98np 60 14 trauma trauma NN cord-274510-fo7p98np 60 15 patients patient NNS cord-274510-fo7p98np 60 16 as as RB cord-274510-fo7p98np 60 17 well well RB cord-274510-fo7p98np 60 18 as as IN cord-274510-fo7p98np 60 19 complete complete JJ cord-274510-fo7p98np 60 20 depletion depletion NN cord-274510-fo7p98np 60 21 of of IN cord-274510-fo7p98np 60 22 free free JJ cord-274510-fo7p98np 60 23 DBP dbp NN cord-274510-fo7p98np 60 24 in in IN cord-274510-fo7p98np 60 25 those those DT cord-274510-fo7p98np 60 26 affected affect VBN cord-274510-fo7p98np 60 27 by by IN cord-274510-fo7p98np 60 28 septic septic JJ cord-274510-fo7p98np 60 29 shock shock NN cord-274510-fo7p98np 60 30 [ [ -LRB- cord-274510-fo7p98np 60 31 33 33 CD cord-274510-fo7p98np 60 32 ] ] -RRB- cord-274510-fo7p98np 60 33 [ [ -LRB- cord-274510-fo7p98np 60 34 34 34 CD cord-274510-fo7p98np 60 35 ] ] -RRB- cord-274510-fo7p98np 60 36 . . . cord-274510-fo7p98np 61 1 These these DT cord-274510-fo7p98np 61 2 data datum NNS cord-274510-fo7p98np 61 3 could could MD cord-274510-fo7p98np 61 4 provide provide VB cord-274510-fo7p98np 61 5 support support NN cord-274510-fo7p98np 61 6 for for IN cord-274510-fo7p98np 61 7 pathogenic pathogenic JJ cord-274510-fo7p98np 61 8 explanations explanation NNS cord-274510-fo7p98np 61 9 of of IN cord-274510-fo7p98np 61 10 cellular cellular JJ cord-274510-fo7p98np 61 11 and and CC cord-274510-fo7p98np 61 12 tissue tissue NN cord-274510-fo7p98np 61 13 damage damage NN cord-274510-fo7p98np 61 14 by by IN cord-274510-fo7p98np 61 15 SARS SARS NNP cord-274510-fo7p98np 61 16 - - HYPH cord-274510-fo7p98np 61 17 CoV-2 CoV-2 NNP cord-274510-fo7p98np 61 18 and and CC cord-274510-fo7p98np 61 19 , , , cord-274510-fo7p98np 61 20 at at IN cord-274510-fo7p98np 61 21 the the DT cord-274510-fo7p98np 61 22 same same JJ cord-274510-fo7p98np 61 23 time time NN cord-274510-fo7p98np 61 24 , , , cord-274510-fo7p98np 61 25 for for IN cord-274510-fo7p98np 61 26 the the DT cord-274510-fo7p98np 61 27 therapeutic therapeutic JJ cord-274510-fo7p98np 61 28 use use NN cord-274510-fo7p98np 61 29 of of IN cord-274510-fo7p98np 61 30 DBP DBP NNP cord-274510-fo7p98np 61 31 to to TO cord-274510-fo7p98np 61 32 bind bind VB cord-274510-fo7p98np 61 33 extracellular extracellular JJ cord-274510-fo7p98np 61 34 actin actin NN cord-274510-fo7p98np 61 35 and and CC cord-274510-fo7p98np 61 36 counteract counteract VB cord-274510-fo7p98np 61 37 microcirculatory microcirculatory JJ cord-274510-fo7p98np 61 38 alterations alteration NNS cord-274510-fo7p98np 61 39 . . . cord-274510-fo7p98np 62 1 Whereas whereas IN cord-274510-fo7p98np 62 2 DBP DBP NNP cord-274510-fo7p98np 62 3 also also RB cord-274510-fo7p98np 62 4 binds bind VBZ cord-274510-fo7p98np 62 5 free free JJ cord-274510-fo7p98np 62 6 fatty fatty JJ cord-274510-fo7p98np 62 7 acids acid NNS cord-274510-fo7p98np 62 8 , , , cord-274510-fo7p98np 62 9 it -PRON- PRP cord-274510-fo7p98np 62 10 was be VBD cord-274510-fo7p98np 62 11 shown show VBN cord-274510-fo7p98np 62 12 that that IN cord-274510-fo7p98np 62 13 the the DT cord-274510-fo7p98np 62 14 administration administration NN cord-274510-fo7p98np 62 15 of of IN cord-274510-fo7p98np 62 16 GcMAF GcMAF NNP cord-274510-fo7p98np 62 17 complexed complexe VBN cord-274510-fo7p98np 62 18 with with IN cord-274510-fo7p98np 62 19 oleic oleic JJ cord-274510-fo7p98np 62 20 acid acid NN cord-274510-fo7p98np 62 21 ( ( -LRB- cord-274510-fo7p98np 62 22 OA OA NNP cord-274510-fo7p98np 62 23 ) ) -RRB- cord-274510-fo7p98np 62 24 via via IN cord-274510-fo7p98np 62 25 nebulisation nebulisation NN cord-274510-fo7p98np 62 26 or or CC cord-274510-fo7p98np 62 27 subcutaneous subcutaneous JJ cord-274510-fo7p98np 62 28 injection injection NN cord-274510-fo7p98np 62 29 led lead VBD cord-274510-fo7p98np 62 30 to to IN cord-274510-fo7p98np 62 31 rapid rapid JJ cord-274510-fo7p98np 62 32 decrease decrease NN cord-274510-fo7p98np 62 33 of of IN cord-274510-fo7p98np 62 34 blood blood NN cord-274510-fo7p98np 62 35 pressure pressure NN cord-274510-fo7p98np 62 36 and and CC cord-274510-fo7p98np 62 37 increase increase NN cord-274510-fo7p98np 62 38 in in IN cord-274510-fo7p98np 62 39 splenic splenic JJ cord-274510-fo7p98np 62 40 blood blood NN cord-274510-fo7p98np 62 41 flow flow NN cord-274510-fo7p98np 62 42 , , , cord-274510-fo7p98np 62 43 as as IN cord-274510-fo7p98np 62 44 a a DT cord-274510-fo7p98np 62 45 result result NN cord-274510-fo7p98np 62 46 of of IN cord-274510-fo7p98np 62 47 a a DT cord-274510-fo7p98np 62 48 verisimilar verisimilar JJ cord-274510-fo7p98np 62 49 synergistic synergistic JJ cord-274510-fo7p98np 62 50 NO no DT cord-274510-fo7p98np 62 51 release release NN cord-274510-fo7p98np 62 52 by by IN cord-274510-fo7p98np 62 53 OA OA NNP cord-274510-fo7p98np 62 54 - - HYPH cord-274510-fo7p98np 62 55 GcMAF GcMAF NNP cord-274510-fo7p98np 62 56 - - HYPH cord-274510-fo7p98np 62 57 activated activate VBN cord-274510-fo7p98np 62 58 alveolar alveolar NN cord-274510-fo7p98np 62 59 and and CC cord-274510-fo7p98np 62 60 splenic splenic JJ cord-274510-fo7p98np 62 61 macrophages macrophage NNS cord-274510-fo7p98np 62 62 [ [ -LRB- cord-274510-fo7p98np 62 63 31 31 CD cord-274510-fo7p98np 62 64 ] ] -RRB- cord-274510-fo7p98np 62 65 . . . cord-274510-fo7p98np 63 1 Severe severe JJ cord-274510-fo7p98np 63 2 or or CC cord-274510-fo7p98np 63 3 critically critically RB cord-274510-fo7p98np 63 4 ill ill JJ cord-274510-fo7p98np 64 1 COVID-19 covid-19 JJ cord-274510-fo7p98np 64 2 patients patient NNS cord-274510-fo7p98np 64 3 developed develop VBD cord-274510-fo7p98np 64 4 clinical clinical JJ cord-274510-fo7p98np 64 5 typical typical JJ cord-274510-fo7p98np 64 6 manifestations manifestation NNS cord-274510-fo7p98np 64 7 of of IN cord-274510-fo7p98np 64 8 shock shock NN cord-274510-fo7p98np 64 9 , , , cord-274510-fo7p98np 64 10 even even RB cord-274510-fo7p98np 64 11 in in IN cord-274510-fo7p98np 64 12 the the DT cord-274510-fo7p98np 64 13 absence absence NN cord-274510-fo7p98np 64 14 of of IN cord-274510-fo7p98np 64 15 overt overt JJ cord-274510-fo7p98np 64 16 hypotension hypotension NN cord-274510-fo7p98np 64 17 [ [ -LRB- cord-274510-fo7p98np 64 18 7 7 CD cord-274510-fo7p98np 64 19 ] ] -RRB- cord-274510-fo7p98np 64 20 . . . cord-274510-fo7p98np 65 1 Furthermore furthermore RB cord-274510-fo7p98np 65 2 , , , cord-274510-fo7p98np 65 3 it -PRON- PRP cord-274510-fo7p98np 65 4 was be VBD cord-274510-fo7p98np 65 5 found find VBN cord-274510-fo7p98np 65 6 that that IN cord-274510-fo7p98np 65 7 GcMAF GcMAF NNP cord-274510-fo7p98np 65 8 can can MD cord-274510-fo7p98np 65 9 inhibit inhibit VB cord-274510-fo7p98np 65 10 the the DT cord-274510-fo7p98np 65 11 angiogenesis angiogenesis NN cord-274510-fo7p98np 65 12 induced induce VBN cord-274510-fo7p98np 65 13 by by IN cord-274510-fo7p98np 65 14 proinflammatory proinflammatory JJ cord-274510-fo7p98np 65 15 prostaglandin prostaglandin NN cord-274510-fo7p98np 65 16 E1 e1 NN cord-274510-fo7p98np 65 17 [ [ -LRB- cord-274510-fo7p98np 65 18 40 40 CD cord-274510-fo7p98np 65 19 ] ] -RRB- cord-274510-fo7p98np 65 20 , , , cord-274510-fo7p98np 65 21 which which WDT cord-274510-fo7p98np 65 22 serves serve VBZ cord-274510-fo7p98np 65 23 roles role NNS cord-274510-fo7p98np 65 24 in in IN cord-274510-fo7p98np 65 25 the the DT cord-274510-fo7p98np 65 26 promotion promotion NN cord-274510-fo7p98np 65 27 of of IN cord-274510-fo7p98np 65 28 vascular vascular JJ cord-274510-fo7p98np 65 29 endothelial endothelial JJ cord-274510-fo7p98np 65 30 growth growth NN cord-274510-fo7p98np 65 31 factor factor NN cord-274510-fo7p98np 65 32 ( ( -LRB- cord-274510-fo7p98np 65 33 VEGF VEGF NNP cord-274510-fo7p98np 65 34 ) ) -RRB- cord-274510-fo7p98np 65 35 expression expression NN cord-274510-fo7p98np 65 36 [ [ -LRB- cord-274510-fo7p98np 65 37 41 41 CD cord-274510-fo7p98np 65 38 ] ] -RRB- cord-274510-fo7p98np 65 39 . . . cord-274510-fo7p98np 66 1 A a DT cord-274510-fo7p98np 66 2 key key JJ cord-274510-fo7p98np 66 3 role role NN cord-274510-fo7p98np 66 4 of of IN cord-274510-fo7p98np 66 5 VEGF VEGF NNP cord-274510-fo7p98np 66 6 in in IN cord-274510-fo7p98np 66 7 acute acute JJ cord-274510-fo7p98np 66 8 lung lung NN cord-274510-fo7p98np 66 9 injury injury NN cord-274510-fo7p98np 66 10 and and CC cord-274510-fo7p98np 66 11 ARDS ARDS NNP cord-274510-fo7p98np 66 12 was be VBD cord-274510-fo7p98np 66 13 confirmed confirm VBN cord-274510-fo7p98np 66 14 [ [ -LRB- cord-274510-fo7p98np 66 15 42 42 CD cord-274510-fo7p98np 66 16 ] ] -RRB- cord-274510-fo7p98np 66 17 . . . cord-274510-fo7p98np 67 1 Reflecting reflect VBG cord-274510-fo7p98np 67 2 the the DT cord-274510-fo7p98np 67 3 fact fact NN cord-274510-fo7p98np 67 4 that that IN cord-274510-fo7p98np 67 5 clinical clinical JJ cord-274510-fo7p98np 67 6 features feature NNS cord-274510-fo7p98np 67 7 and and CC cord-274510-fo7p98np 67 8 severity severity NN cord-274510-fo7p98np 67 9 of of IN cord-274510-fo7p98np 67 10 symptoms symptom NNS cord-274510-fo7p98np 67 11 vary vary VBP cord-274510-fo7p98np 67 12 widely widely RB cord-274510-fo7p98np 67 13 between between IN cord-274510-fo7p98np 67 14 and and CC cord-274510-fo7p98np 67 15 within within IN cord-274510-fo7p98np 67 16 each each DT cord-274510-fo7p98np 67 17 COVID-19 covid-19 JJ cord-274510-fo7p98np 67 18 patient patient NN cord-274510-fo7p98np 67 19 , , , cord-274510-fo7p98np 67 20 with with IN cord-274510-fo7p98np 67 21 older old JJR cord-274510-fo7p98np 67 22 males male NNS cord-274510-fo7p98np 67 23 more more RBR cord-274510-fo7p98np 67 24 likely likely JJ cord-274510-fo7p98np 67 25 to to TO cord-274510-fo7p98np 67 26 be be VB cord-274510-fo7p98np 67 27 affected affect VBN cord-274510-fo7p98np 67 28 and and CC cord-274510-fo7p98np 67 29 in in IN cord-274510-fo7p98np 67 30 a a DT cord-274510-fo7p98np 67 31 more more RBR cord-274510-fo7p98np 67 32 severe severe JJ cord-274510-fo7p98np 67 33 manner manner NN cord-274510-fo7p98np 67 34 [ [ -LRB- cord-274510-fo7p98np 67 35 43 43 CD cord-274510-fo7p98np 67 36 ] ] -RRB- cord-274510-fo7p98np 67 37 , , , cord-274510-fo7p98np 67 38 we -PRON- PRP cord-274510-fo7p98np 67 39 sought seek VBD cord-274510-fo7p98np 67 40 to to TO cord-274510-fo7p98np 67 41 relate relate VB cord-274510-fo7p98np 67 42 it -PRON- PRP cord-274510-fo7p98np 67 43 with with IN cord-274510-fo7p98np 67 44 some some DT cord-274510-fo7p98np 67 45 special special JJ cord-274510-fo7p98np 67 46 feature feature NN cord-274510-fo7p98np 67 47 of of IN cord-274510-fo7p98np 67 48 DBP DBP NNP cord-274510-fo7p98np 67 49 . . . cord-274510-fo7p98np 68 1 Several several JJ cord-274510-fo7p98np 68 2 studies study NNS cord-274510-fo7p98np 68 3 showed show VBD cord-274510-fo7p98np 68 4 that that IN cord-274510-fo7p98np 68 5 the the DT cord-274510-fo7p98np 68 6 polymorphisms polymorphism NNS cord-274510-fo7p98np 68 7 of of IN cord-274510-fo7p98np 68 8 DBP DBP NNP cord-274510-fo7p98np 68 9 were be VBD cord-274510-fo7p98np 68 10 associated associate VBN cord-274510-fo7p98np 68 11 with with IN cord-274510-fo7p98np 68 12 susceptibility susceptibility NN cord-274510-fo7p98np 68 13 or or CC cord-274510-fo7p98np 68 14 resistance resistance NN cord-274510-fo7p98np 68 15 to to IN cord-274510-fo7p98np 68 16 disease disease NN cord-274510-fo7p98np 68 17 states state NNS cord-274510-fo7p98np 68 18 including include VBG cord-274510-fo7p98np 68 19 chronic chronic JJ cord-274510-fo7p98np 68 20 obstructive obstructive JJ cord-274510-fo7p98np 68 21 pulmonary pulmonary JJ cord-274510-fo7p98np 68 22 disease disease NN cord-274510-fo7p98np 68 23 [ [ -LRB- cord-274510-fo7p98np 68 24 44 44 CD cord-274510-fo7p98np 68 25 ] ] -RRB- cord-274510-fo7p98np 68 26 [ [ -LRB- cord-274510-fo7p98np 68 27 45 45 CD cord-274510-fo7p98np 68 28 ] ] -RRB- cord-274510-fo7p98np 68 29 . . . cord-274510-fo7p98np 69 1 Moreover moreover RB cord-274510-fo7p98np 69 2 , , , cord-274510-fo7p98np 69 3 whereas whereas IN cord-274510-fo7p98np 69 4 androgens androgen NNS cord-274510-fo7p98np 69 5 were be VBD cord-274510-fo7p98np 69 6 not not RB cord-274510-fo7p98np 69 7 found find VBN cord-274510-fo7p98np 69 8 to to TO cord-274510-fo7p98np 69 9 have have VB cord-274510-fo7p98np 69 10 any any DT cord-274510-fo7p98np 69 11 effect effect NN cord-274510-fo7p98np 69 12 on on IN cord-274510-fo7p98np 69 13 circulating circulate VBG cord-274510-fo7p98np 69 14 levels level NNS cord-274510-fo7p98np 69 15 of of IN cord-274510-fo7p98np 69 16 DBP dbp NN cord-274510-fo7p98np 69 17 , , , cord-274510-fo7p98np 69 18 exposure exposure NN cord-274510-fo7p98np 69 19 to to IN cord-274510-fo7p98np 69 20 high high JJ cord-274510-fo7p98np 69 21 levels level NNS cord-274510-fo7p98np 69 22 of of IN cord-274510-fo7p98np 69 23 estrogens estrogen NNS cord-274510-fo7p98np 69 24 increased increase VBD cord-274510-fo7p98np 69 25 them -PRON- PRP cord-274510-fo7p98np 69 26 by by IN cord-274510-fo7p98np 69 27 up up IN cord-274510-fo7p98np 69 28 to to TO cord-274510-fo7p98np 69 29 50 50 CD cord-274510-fo7p98np 69 30 % % NN cord-274510-fo7p98np 69 31 , , , cord-274510-fo7p98np 69 32 suggesting suggest VBG cord-274510-fo7p98np 69 33 a a DT cord-274510-fo7p98np 69 34 potential potential JJ cord-274510-fo7p98np 69 35 protective protective JJ cord-274510-fo7p98np 69 36 role role NN cord-274510-fo7p98np 69 37 of of IN cord-274510-fo7p98np 69 38 estrogens estrogen NNS cord-274510-fo7p98np 69 39 against against IN cord-274510-fo7p98np 69 40 COVID-19 COVID-19 NNP cord-274510-fo7p98np 69 41 [ [ -LRB- cord-274510-fo7p98np 69 42 28 28 CD cord-274510-fo7p98np 69 43 ] ] -RRB- cord-274510-fo7p98np 69 44 . . . cord-274510-fo7p98np 70 1 On on IN cord-274510-fo7p98np 70 2 the the DT cord-274510-fo7p98np 70 3 other other JJ cord-274510-fo7p98np 70 4 hand hand NN cord-274510-fo7p98np 70 5 , , , cord-274510-fo7p98np 70 6 in in IN cord-274510-fo7p98np 70 7 relation relation NN cord-274510-fo7p98np 70 8 to to IN cord-274510-fo7p98np 70 9 vitamin vitamin NN cord-274510-fo7p98np 70 10 D d NN cord-274510-fo7p98np 70 11 status status NN cord-274510-fo7p98np 70 12 , , , cord-274510-fo7p98np 70 13 advanced advanced JJ cord-274510-fo7p98np 70 14 age age NN cord-274510-fo7p98np 70 15 was be VBD cord-274510-fo7p98np 70 16 recognized recognize VBN cord-274510-fo7p98np 70 17 as as IN cord-274510-fo7p98np 70 18 one one CD cord-274510-fo7p98np 70 19 of of IN cord-274510-fo7p98np 70 20 the the DT cord-274510-fo7p98np 70 21 major major JJ cord-274510-fo7p98np 70 22 risk risk NN cord-274510-fo7p98np 70 23 factors factor NNS cord-274510-fo7p98np 70 24 for for IN cord-274510-fo7p98np 70 25 vitamin vitamin NN cord-274510-fo7p98np 70 26 D d NN cord-274510-fo7p98np 70 27 deficiency deficiency NN cord-274510-fo7p98np 70 28 [ [ -LRB- cord-274510-fo7p98np 70 29 46 46 CD cord-274510-fo7p98np 70 30 ] ] -RRB- cord-274510-fo7p98np 70 31 . . . cord-274510-fo7p98np 71 1 Animal animal NN cord-274510-fo7p98np 71 2 - - HYPH cord-274510-fo7p98np 71 3 based base VBN cord-274510-fo7p98np 71 4 studies study NNS cord-274510-fo7p98np 71 5 also also RB cord-274510-fo7p98np 71 6 demonstrated demonstrate VBD cord-274510-fo7p98np 71 7 that that IN cord-274510-fo7p98np 71 8 deficiencies deficiency NNS cord-274510-fo7p98np 71 9 in in IN cord-274510-fo7p98np 71 10 both both DT cord-274510-fo7p98np 71 11 dietary dietary JJ cord-274510-fo7p98np 71 12 protein protein NN cord-274510-fo7p98np 71 13 - - HYPH cord-274510-fo7p98np 71 14 and and CC cord-274510-fo7p98np 71 15 energy energy NN cord-274510-fo7p98np 71 16 - - HYPH cord-274510-fo7p98np 71 17 intake intake NN cord-274510-fo7p98np 71 18 decreased decrease VBD cord-274510-fo7p98np 71 19 the the DT cord-274510-fo7p98np 71 20 concentration concentration NN cord-274510-fo7p98np 71 21 of of IN cord-274510-fo7p98np 71 22 DBP DBP NNP cord-274510-fo7p98np 71 23 in in IN cord-274510-fo7p98np 71 24 the the DT cord-274510-fo7p98np 71 25 circulation circulation NN cord-274510-fo7p98np 71 26 [ [ -LRB- cord-274510-fo7p98np 71 27 47 47 CD cord-274510-fo7p98np 71 28 ] ] -RRB- cord-274510-fo7p98np 71 29 . . . cord-274510-fo7p98np 72 1 These these DT cord-274510-fo7p98np 72 2 data datum NNS cord-274510-fo7p98np 72 3 seem seem VBP cord-274510-fo7p98np 72 4 to to TO cord-274510-fo7p98np 72 5 be be VB cord-274510-fo7p98np 72 6 in in IN cord-274510-fo7p98np 72 7 line line NN cord-274510-fo7p98np 72 8 with with IN cord-274510-fo7p98np 72 9 the the DT cord-274510-fo7p98np 72 10 growing grow VBG cord-274510-fo7p98np 72 11 evidence evidence NN cord-274510-fo7p98np 72 12 that that IN cord-274510-fo7p98np 72 13 vitamin vitamin NN cord-274510-fo7p98np 72 14 D d NN cord-274510-fo7p98np 72 15 supplementation supplementation NN cord-274510-fo7p98np 72 16 could could MD cord-274510-fo7p98np 72 17 reduce reduce VB cord-274510-fo7p98np 72 18 the the DT cord-274510-fo7p98np 72 19 risk risk NN cord-274510-fo7p98np 72 20 of of IN cord-274510-fo7p98np 72 21 COVID-19 covid-19 JJ cord-274510-fo7p98np 72 22 infections infection NNS cord-274510-fo7p98np 72 23 and and CC cord-274510-fo7p98np 72 24 deaths death NNS cord-274510-fo7p98np 72 25 [ [ -LRB- cord-274510-fo7p98np 72 26 48 48 CD cord-274510-fo7p98np 72 27 ] ] -RRB- cord-274510-fo7p98np 72 28 [ [ -LRB- cord-274510-fo7p98np 72 29 49 49 CD cord-274510-fo7p98np 72 30 ] ] -RRB- cord-274510-fo7p98np 72 31 [ [ -LRB- cord-274510-fo7p98np 72 32 50 50 CD cord-274510-fo7p98np 72 33 ] ] -RRB- cord-274510-fo7p98np 72 34 . . . cord-274510-fo7p98np 73 1 To to IN cord-274510-fo7p98np 73 2 date date NN cord-274510-fo7p98np 73 3 , , , cord-274510-fo7p98np 73 4 a a DT cord-274510-fo7p98np 73 5 pharmaceutical pharmaceutical JJ cord-274510-fo7p98np 73 6 grade grade NN cord-274510-fo7p98np 73 7 GcMAF GcMAF NNP cord-274510-fo7p98np 73 8 agent agent NN cord-274510-fo7p98np 73 9 that that WDT cord-274510-fo7p98np 73 10 can can MD cord-274510-fo7p98np 73 11 be be VB cord-274510-fo7p98np 73 12 administered administer VBN cord-274510-fo7p98np 73 13 to to IN cord-274510-fo7p98np 73 14 patients patient NNS cord-274510-fo7p98np 73 15 with with IN cord-274510-fo7p98np 73 16 COVID-19 COVID-19 NNP cord-274510-fo7p98np 73 17 is be VBZ cord-274510-fo7p98np 73 18 not not RB cord-274510-fo7p98np 73 19 developed develop VBN cord-274510-fo7p98np 73 20 yet yet RB cord-274510-fo7p98np 73 21 , , , cord-274510-fo7p98np 73 22 but but CC cord-274510-fo7p98np 73 23 , , , cord-274510-fo7p98np 73 24 as as IN cord-274510-fo7p98np 73 25 our -PRON- PRP$ cord-274510-fo7p98np 73 26 hypothesis hypothesis NN cord-274510-fo7p98np 73 27 suggests suggest VBZ cord-274510-fo7p98np 73 28 that that IN cord-274510-fo7p98np 73 29 GcMAF GcMAF NNP cord-274510-fo7p98np 73 30 , , , cord-274510-fo7p98np 73 31 an an DT cord-274510-fo7p98np 73 32 activator activator NN cord-274510-fo7p98np 73 33 of of IN cord-274510-fo7p98np 73 34 macrophage macrophage NN cord-274510-fo7p98np 73 35 , , , cord-274510-fo7p98np 73 36 a a DT cord-274510-fo7p98np 73 37 key key JJ cord-274510-fo7p98np 73 38 player player NN cord-274510-fo7p98np 73 39 of of IN cord-274510-fo7p98np 73 40 innate innate JJ cord-274510-fo7p98np 73 41 immunity immunity NN cord-274510-fo7p98np 73 42 , , , cord-274510-fo7p98np 73 43 may may MD cord-274510-fo7p98np 73 44 be be VB cord-274510-fo7p98np 73 45 effective effective JJ cord-274510-fo7p98np 73 46 in in IN cord-274510-fo7p98np 73 47 suppressing suppress VBG cord-274510-fo7p98np 73 48 the the DT cord-274510-fo7p98np 73 49 severity severity NN cord-274510-fo7p98np 73 50 of of IN cord-274510-fo7p98np 73 51 COVID-19-induced COVID-19-induced NNP cord-274510-fo7p98np 73 52 immune immune JJ cord-274510-fo7p98np 73 53 responses response NNS cord-274510-fo7p98np 73 54 , , , cord-274510-fo7p98np 73 55 it -PRON- PRP cord-274510-fo7p98np 73 56 would would MD cord-274510-fo7p98np 73 57 be be VB cord-274510-fo7p98np 73 58 advisable advisable JJ cord-274510-fo7p98np 73 59 to to TO cord-274510-fo7p98np 73 60 proceed proceed VB cord-274510-fo7p98np 73 61 in in IN cord-274510-fo7p98np 73 62 this this DT cord-274510-fo7p98np 73 63 way way NN cord-274510-fo7p98np 73 64 . . . cord-274510-fo7p98np 74 1 In in IN cord-274510-fo7p98np 74 2 the the DT cord-274510-fo7p98np 74 3 GcMAF GcMAF NNP cord-274510-fo7p98np 74 4 development development NN cord-274510-fo7p98np 74 5 timeline timeline NN cord-274510-fo7p98np 74 6 , , , cord-274510-fo7p98np 74 7 there there EX cord-274510-fo7p98np 74 8 have have VBP cord-274510-fo7p98np 74 9 been be VBN cord-274510-fo7p98np 74 10 three three CD cord-274510-fo7p98np 74 11 major major JJ cord-274510-fo7p98np 74 12 types type NNS cord-274510-fo7p98np 74 13 of of IN cord-274510-fo7p98np 74 14 GcMAF GcMAF NNPS cord-274510-fo7p98np 74 15 until until IN cord-274510-fo7p98np 74 16 now now RB cord-274510-fo7p98np 74 17 : : : cord-274510-fo7p98np 74 18 purified purify VBN cord-274510-fo7p98np 74 19 ( ( -LRB- cord-274510-fo7p98np 74 20 i.e. i.e. FW cord-274510-fo7p98np 74 21 first first JJ cord-274510-fo7p98np 74 22 - - HYPH cord-274510-fo7p98np 74 23 generation generation NN cord-274510-fo7p98np 74 24 ) ) -RRB- cord-274510-fo7p98np 75 1 GcMAF GcMAF NNS cord-274510-fo7p98np 75 2 , , , cord-274510-fo7p98np 75 3 serum serum NN cord-274510-fo7p98np 75 4 ( ( -LRB- cord-274510-fo7p98np 75 5 i.e. i.e. FW cord-274510-fo7p98np 75 6 second second JJ cord-274510-fo7p98np 75 7 - - HYPH cord-274510-fo7p98np 75 8 generation generation NN cord-274510-fo7p98np 75 9 ) ) -RRB- cord-274510-fo7p98np 75 10 GcMAF GcMAF NNPS cord-274510-fo7p98np 75 11 , , , cord-274510-fo7p98np 75 12 and and CC cord-274510-fo7p98np 75 13 oral oral JJ cord-274510-fo7p98np 75 14 colostrum colostrum NN cord-274510-fo7p98np 75 15 MAF MAF NNP cord-274510-fo7p98np 75 16 ( ( -LRB- cord-274510-fo7p98np 75 17 i.e. i.e. FW cord-274510-fo7p98np 75 18 third third JJ cord-274510-fo7p98np 75 19 - - HYPH cord-274510-fo7p98np 75 20 generation generation NN cord-274510-fo7p98np 75 21 GcMAF GcMAF NNP cord-274510-fo7p98np 75 22 ) ) -RRB- cord-274510-fo7p98np 75 23 . . . cord-274510-fo7p98np 76 1 The the DT cord-274510-fo7p98np 76 2 first first JJ cord-274510-fo7p98np 76 3 - - HYPH cord-274510-fo7p98np 76 4 generation generation NN cord-274510-fo7p98np 76 5 GcMAF GcMAF NNP cord-274510-fo7p98np 76 6 is be VBZ cord-274510-fo7p98np 76 7 produced produce VBN cord-274510-fo7p98np 76 8 from from IN cord-274510-fo7p98np 76 9 Gc Gc NNP cord-274510-fo7p98np 76 10 protein protein NN cord-274510-fo7p98np 76 11 isolated isolate VBN cord-274510-fo7p98np 76 12 from from IN cord-274510-fo7p98np 76 13 human human JJ cord-274510-fo7p98np 76 14 serum serum NN cord-274510-fo7p98np 76 15 by by IN cord-274510-fo7p98np 76 16 an an DT cord-274510-fo7p98np 76 17 artificial artificial JJ cord-274510-fo7p98np 76 18 enzymatic enzymatic JJ cord-274510-fo7p98np 76 19 method method NN cord-274510-fo7p98np 76 20 using use VBG cord-274510-fo7p98np 76 21 an an DT cord-274510-fo7p98np 76 22 affinity affinity NN cord-274510-fo7p98np 76 23 column column NN cord-274510-fo7p98np 76 24 modified modify VBN cord-274510-fo7p98np 76 25 with with IN cord-274510-fo7p98np 76 26 25-hydroxy 25-hydroxy CD cord-274510-fo7p98np 76 27 - - HYPH cord-274510-fo7p98np 76 28 vitamin vitamin NN cord-274510-fo7p98np 76 29 D3 D3 NNP cord-274510-fo7p98np 76 30 [ [ -LRB- cord-274510-fo7p98np 76 31 51 51 CD cord-274510-fo7p98np 76 32 ] ] -RRB- cord-274510-fo7p98np 76 33 . . . cord-274510-fo7p98np 77 1 The the DT cord-274510-fo7p98np 77 2 second second JJ cord-274510-fo7p98np 77 3 - - HYPH cord-274510-fo7p98np 77 4 generation generation NN cord-274510-fo7p98np 77 5 GcMAF GcMAF NNP cord-274510-fo7p98np 77 6 is be VBZ cord-274510-fo7p98np 77 7 prepared prepare VBN cord-274510-fo7p98np 77 8 from from IN cord-274510-fo7p98np 77 9 degalactosylated degalactosylate VBN cord-274510-fo7p98np 77 10 / / SYM cord-274510-fo7p98np 77 11 desialylated desialylated JJ cord-274510-fo7p98np 77 12 human human JJ cord-274510-fo7p98np 77 13 serum serum NN cord-274510-fo7p98np 77 14 without without IN cord-274510-fo7p98np 77 15 isolation isolation NN cord-274510-fo7p98np 77 16 of of IN cord-274510-fo7p98np 77 17 Gc Gc NNP cord-274510-fo7p98np 77 18 protein protein NN cord-274510-fo7p98np 77 19 using use VBG cord-274510-fo7p98np 77 20 vitamin vitamin NN cord-274510-fo7p98np 77 21 D d NN cord-274510-fo7p98np 77 22 affinity affinity NN cord-274510-fo7p98np 77 23 chromatography chromatography NN cord-274510-fo7p98np 77 24 , , , cord-274510-fo7p98np 77 25 leading lead VBG cord-274510-fo7p98np 77 26 to to IN cord-274510-fo7p98np 77 27 a a DT cord-274510-fo7p98np 77 28 higher high JJR cord-274510-fo7p98np 77 29 concentration concentration NN cord-274510-fo7p98np 77 30 , , , cord-274510-fo7p98np 77 31 stability stability NN cord-274510-fo7p98np 77 32 and and CC cord-274510-fo7p98np 77 33 activity activity NN cord-274510-fo7p98np 77 34 of of IN cord-274510-fo7p98np 77 35 the the DT cord-274510-fo7p98np 77 36 final final JJ cord-274510-fo7p98np 77 37 GcMAF GcMAF NNPS cord-274510-fo7p98np 77 38 , , , cord-274510-fo7p98np 77 39 without without IN cord-274510-fo7p98np 77 40 the the DT cord-274510-fo7p98np 77 41 risk risk NN cord-274510-fo7p98np 77 42 of of IN cord-274510-fo7p98np 77 43 cross cross NN cord-274510-fo7p98np 77 44 - - NN cord-274510-fo7p98np 77 45 contamination contamination NN cord-274510-fo7p98np 77 46 between between IN cord-274510-fo7p98np 77 47 different different JJ cord-274510-fo7p98np 77 48 serum serum NN cord-274510-fo7p98np 77 49 samples sample NNS cord-274510-fo7p98np 77 50 [ [ -LRB- cord-274510-fo7p98np 77 51 52 52 CD cord-274510-fo7p98np 77 52 ] ] -RRB- cord-274510-fo7p98np 77 53 . . . cord-274510-fo7p98np 78 1 In in IN cord-274510-fo7p98np 78 2 addition addition NN cord-274510-fo7p98np 78 3 , , , cord-274510-fo7p98np 78 4 the the DT cord-274510-fo7p98np 78 5 second second JJ cord-274510-fo7p98np 78 6 - - HYPH cord-274510-fo7p98np 78 7 generation generation NN cord-274510-fo7p98np 78 8 GcMAF GcMAF NNP cord-274510-fo7p98np 78 9 has have VBZ cord-274510-fo7p98np 78 10 been be VBN cord-274510-fo7p98np 78 11 shown show VBN cord-274510-fo7p98np 78 12 to to TO cord-274510-fo7p98np 78 13 have have VB cord-274510-fo7p98np 78 14 increasing increase VBG cord-274510-fo7p98np 78 15 activity activity NN cord-274510-fo7p98np 78 16 of of IN cord-274510-fo7p98np 78 17 macrophages macrophage NNS cord-274510-fo7p98np 78 18 , , , cord-274510-fo7p98np 78 19 superoxide superoxide JJ cord-274510-fo7p98np 78 20 radical radical JJ cord-274510-fo7p98np 78 21 generation generation NN cord-274510-fo7p98np 78 22 , , , cord-274510-fo7p98np 78 23 anti anti JJ cord-274510-fo7p98np 78 24 - - JJ cord-274510-fo7p98np 78 25 angiogenetic angiogenetic JJ cord-274510-fo7p98np 78 26 effects effect NNS cord-274510-fo7p98np 78 27 , , , cord-274510-fo7p98np 78 28 and and CC cord-274510-fo7p98np 78 29 antitumor antitumor JJ cord-274510-fo7p98np 78 30 effects effect NNS cord-274510-fo7p98np 78 31 . . . cord-274510-fo7p98np 79 1 In in IN cord-274510-fo7p98np 79 2 2014 2014 CD cord-274510-fo7p98np 79 3 , , , cord-274510-fo7p98np 79 4 Saisei Saisei NNP cord-274510-fo7p98np 79 5 Mirai Mirai NNP cord-274510-fo7p98np 79 6 clinics clinic NNS cord-274510-fo7p98np 79 7 ( ( -LRB- cord-274510-fo7p98np 79 8 cell cell NN cord-274510-fo7p98np 79 9 processing processing NN cord-274510-fo7p98np 79 10 center center NN cord-274510-fo7p98np 79 11 , , , cord-274510-fo7p98np 79 12 clinic clinic NN cord-274510-fo7p98np 79 13 in in IN cord-274510-fo7p98np 79 14 Kobe Kobe NNP cord-274510-fo7p98np 79 15 , , , cord-274510-fo7p98np 79 16 Osaka Osaka NNP cord-274510-fo7p98np 79 17 and and CC cord-274510-fo7p98np 79 18 Tokyo Tokyo NNP cord-274510-fo7p98np 79 19 ) ) -RRB- cord-274510-fo7p98np 79 20 , , , cord-274510-fo7p98np 79 21 in in IN cord-274510-fo7p98np 79 22 collaboration collaboration NN cord-274510-fo7p98np 79 23 with with IN cord-274510-fo7p98np 79 24 Tokushima Tokushima NNP cord-274510-fo7p98np 79 25 University University NNP cord-274510-fo7p98np 79 26 , , , cord-274510-fo7p98np 79 27 developed develop VBD cord-274510-fo7p98np 79 28 a a DT cord-274510-fo7p98np 79 29 new new JJ cord-274510-fo7p98np 79 30 form form NN cord-274510-fo7p98np 79 31 of of IN cord-274510-fo7p98np 79 32 GcMAF GcMAF NNP cord-274510-fo7p98np 79 33 made make VBN cord-274510-fo7p98np 79 34 from from IN cord-274510-fo7p98np 79 35 bovine bovine JJ cord-274510-fo7p98np 79 36 colostrum colostrum NN cord-274510-fo7p98np 79 37 [ [ -LRB- cord-274510-fo7p98np 79 38 53 53 CD cord-274510-fo7p98np 79 39 ] ] -RRB- cord-274510-fo7p98np 79 40 . . . cord-274510-fo7p98np 80 1 Colostrum Colostrum NNP cord-274510-fo7p98np 80 2 MAF MAF NNP cord-274510-fo7p98np 80 3 has have VBZ cord-274510-fo7p98np 80 4 the the DT cord-274510-fo7p98np 80 5 advantage advantage NN cord-274510-fo7p98np 80 6 that that IN cord-274510-fo7p98np 80 7 it -PRON- PRP cord-274510-fo7p98np 80 8 can can MD cord-274510-fo7p98np 80 9 be be VB cord-274510-fo7p98np 80 10 orally orally RB cord-274510-fo7p98np 80 11 administered administer VBN cord-274510-fo7p98np 80 12 , , , cord-274510-fo7p98np 80 13 namely namely RB cord-274510-fo7p98np 80 14 , , , cord-274510-fo7p98np 80 15 in in IN cord-274510-fo7p98np 80 16 an an DT cord-274510-fo7p98np 80 17 acid acid NN cord-274510-fo7p98np 80 18 - - HYPH cord-274510-fo7p98np 80 19 resistant resistant JJ cord-274510-fo7p98np 80 20 enteric enteric JJ cord-274510-fo7p98np 80 21 capsule capsule NN cord-274510-fo7p98np 80 22 to to TO cord-274510-fo7p98np 80 23 activate activate VB cord-274510-fo7p98np 80 24 macrophages macrophage NNS cord-274510-fo7p98np 80 25 in in IN cord-274510-fo7p98np 80 26 the the DT cord-274510-fo7p98np 80 27 gut gut NN cord-274510-fo7p98np 80 28 - - HYPH cord-274510-fo7p98np 80 29 associated associate VBN cord-274510-fo7p98np 80 30 lymphoid lymphoid JJ cord-274510-fo7p98np 80 31 tissue tissue NN cord-274510-fo7p98np 80 32 ( ( -LRB- cord-274510-fo7p98np 80 33 GALT GALT NNP cord-274510-fo7p98np 80 34 ) ) -RRB- cord-274510-fo7p98np 80 35 [ [ -LRB- cord-274510-fo7p98np 80 36 54 54 CD cord-274510-fo7p98np 80 37 ] ] -RRB- cord-274510-fo7p98np 80 38 . . . cord-274510-fo7p98np 81 1 This this DT cord-274510-fo7p98np 81 2 is be VBZ cord-274510-fo7p98np 81 3 considered consider VBN cord-274510-fo7p98np 81 4 to to TO cord-274510-fo7p98np 81 5 be be VB cord-274510-fo7p98np 81 6 the the DT cord-274510-fo7p98np 81 7 largest large JJS cord-274510-fo7p98np 81 8 macrophage macrophage NN cord-274510-fo7p98np 81 9 pool pool NN cord-274510-fo7p98np 81 10 in in IN cord-274510-fo7p98np 81 11 the the DT cord-274510-fo7p98np 81 12 body body NN cord-274510-fo7p98np 81 13 playing play VBG cord-274510-fo7p98np 81 14 a a DT cord-274510-fo7p98np 81 15 very very RB cord-274510-fo7p98np 81 16 important important JJ cord-274510-fo7p98np 81 17 role role NN cord-274510-fo7p98np 81 18 in in IN cord-274510-fo7p98np 81 19 maintaining maintain VBG cord-274510-fo7p98np 81 20 and and CC cord-274510-fo7p98np 81 21 regulating regulate VBG cord-274510-fo7p98np 81 22 mucosal mucosal JJ cord-274510-fo7p98np 81 23 immunity immunity NN cord-274510-fo7p98np 81 24 [ [ -LRB- cord-274510-fo7p98np 81 25 54 54 CD cord-274510-fo7p98np 81 26 ] ] -RRB- cord-274510-fo7p98np 81 27 . . . cord-274510-fo7p98np 82 1 Macrophages macrophage NNS cord-274510-fo7p98np 82 2 in in IN cord-274510-fo7p98np 82 3 the the DT cord-274510-fo7p98np 82 4 gastrointestinal gastrointestinal JJ cord-274510-fo7p98np 82 5 mucosa mucosa NN cord-274510-fo7p98np 82 6 also also RB cord-274510-fo7p98np 82 7 could could MD cord-274510-fo7p98np 82 8 modulate modulate VB cord-274510-fo7p98np 82 9 the the DT cord-274510-fo7p98np 82 10 respiratory respiratory JJ cord-274510-fo7p98np 82 11 tract tract NN cord-274510-fo7p98np 82 12 mucosal mucosal JJ cord-274510-fo7p98np 82 13 immunity immunity NN cord-274510-fo7p98np 82 14 through through IN cord-274510-fo7p98np 82 15 immune immune JJ cord-274510-fo7p98np 82 16 regulation regulation NN cord-274510-fo7p98np 82 17 , , , cord-274510-fo7p98np 82 18 the the DT cord-274510-fo7p98np 82 19 so so RB cord-274510-fo7p98np 82 20 - - HYPH cord-274510-fo7p98np 82 21 called call VBN cord-274510-fo7p98np 82 22 " " `` cord-274510-fo7p98np 82 23 gut gut NN cord-274510-fo7p98np 82 24 - - HYPH cord-274510-fo7p98np 82 25 lung lung NN cord-274510-fo7p98np 82 26 axis axis NN cord-274510-fo7p98np 82 27 " " '' cord-274510-fo7p98np 82 28 . . . cord-274510-fo7p98np 83 1 Additionally additionally RB cord-274510-fo7p98np 83 2 , , , cord-274510-fo7p98np 83 3 colostrum colostrum NN cord-274510-fo7p98np 83 4 MAF MAF NNP cord-274510-fo7p98np 83 5 is be VBZ cord-274510-fo7p98np 83 6 administered administer VBN cord-274510-fo7p98np 83 7 as as IN cord-274510-fo7p98np 83 8 a a DT cord-274510-fo7p98np 83 9 powder powder NN cord-274510-fo7p98np 83 10 in in IN cord-274510-fo7p98np 83 11 the the DT cord-274510-fo7p98np 83 12 mouth mouth NN cord-274510-fo7p98np 83 13 to to TO cord-274510-fo7p98np 83 14 activate activate VB cord-274510-fo7p98np 83 15 macrophages macrophage NNS cord-274510-fo7p98np 83 16 in in IN cord-274510-fo7p98np 83 17 the the DT cord-274510-fo7p98np 83 18 lymphoid lymphoid JJ cord-274510-fo7p98np 83 19 tissue tissue NN cord-274510-fo7p98np 83 20 of of IN cord-274510-fo7p98np 83 21 the the DT cord-274510-fo7p98np 83 22 Waldeyer Waldeyer NNP cord-274510-fo7p98np 83 23 's 's POS cord-274510-fo7p98np 83 24 tonsillar tonsillar JJ cord-274510-fo7p98np 83 25 ring ring NN cord-274510-fo7p98np 83 26 . . . cord-274510-fo7p98np 84 1 In in IN cord-274510-fo7p98np 84 2 this this DT cord-274510-fo7p98np 84 3 regard regard NN cord-274510-fo7p98np 84 4 , , , cord-274510-fo7p98np 84 5 it -PRON- PRP cord-274510-fo7p98np 84 6 is be VBZ cord-274510-fo7p98np 84 7 remarkable remarkable JJ cord-274510-fo7p98np 84 8 that that IN cord-274510-fo7p98np 84 9 Angiotensin Angiotensin NNP cord-274510-fo7p98np 84 10 Converting Converting NNP cord-274510-fo7p98np 84 11 Enzyme Enzyme NNP cord-274510-fo7p98np 84 12 2 2 CD cord-274510-fo7p98np 84 13 ( ( -LRB- cord-274510-fo7p98np 84 14 ACE2 ACE2 NNP cord-274510-fo7p98np 84 15 ) ) -RRB- cord-274510-fo7p98np 84 16 , , , cord-274510-fo7p98np 84 17 an an DT cord-274510-fo7p98np 84 18 Entry Entry NNP cord-274510-fo7p98np 84 19 Receptor Receptor NNP cord-274510-fo7p98np 84 20 for for IN cord-274510-fo7p98np 84 21 SARS SARS NNP cord-274510-fo7p98np 84 22 - - HYPH cord-274510-fo7p98np 84 23 CoV-2 CoV-2 NNP cord-274510-fo7p98np 84 24 , , , cord-274510-fo7p98np 84 25 was be VBD cord-274510-fo7p98np 84 26 found find VBN cord-274510-fo7p98np 84 27 to to TO cord-274510-fo7p98np 84 28 be be VB cord-274510-fo7p98np 84 29 highly highly RB cord-274510-fo7p98np 84 30 expressed express VBN cord-274510-fo7p98np 84 31 in in IN cord-274510-fo7p98np 84 32 gastrointestinal gastrointestinal JJ cord-274510-fo7p98np 84 33 epithelial epithelial JJ cord-274510-fo7p98np 84 34 cells cell NNS cord-274510-fo7p98np 84 35 , , , cord-274510-fo7p98np 84 36 providing provide VBG cord-274510-fo7p98np 84 37 a a DT cord-274510-fo7p98np 84 38 prerequisite prerequisite NN cord-274510-fo7p98np 84 39 for for IN cord-274510-fo7p98np 84 40 SARS SARS NNP cord-274510-fo7p98np 84 41 - - HYPH cord-274510-fo7p98np 84 42 CoV-2 CoV-2 NNP cord-274510-fo7p98np 84 43 infection infection NN cord-274510-fo7p98np 84 44 [ [ -LRB- cord-274510-fo7p98np 84 45 55 55 CD cord-274510-fo7p98np 84 46 ] ] -RRB- cord-274510-fo7p98np 84 47 . . . cord-274510-fo7p98np 85 1 On on IN cord-274510-fo7p98np 85 2 this this DT cord-274510-fo7p98np 85 3 base base NN cord-274510-fo7p98np 85 4 , , , cord-274510-fo7p98np 85 5 if if IN cord-274510-fo7p98np 85 6 we -PRON- PRP cord-274510-fo7p98np 85 7 consider consider VBP cord-274510-fo7p98np 85 8 GcMAF GcMAF NNP cord-274510-fo7p98np 85 9 as as IN cord-274510-fo7p98np 85 10 an an DT cord-274510-fo7p98np 85 11 off off JJ cord-274510-fo7p98np 85 12 - - HYPH cord-274510-fo7p98np 85 13 label label NN cord-274510-fo7p98np 85 14 immunomodulating immunomodulate VBG cord-274510-fo7p98np 85 15 agent agent NN cord-274510-fo7p98np 85 16 for for IN cord-274510-fo7p98np 85 17 the the DT cord-274510-fo7p98np 85 18 treatment treatment NN cord-274510-fo7p98np 85 19 of of IN cord-274510-fo7p98np 85 20 COVID-19 COVID-19 NNP cord-274510-fo7p98np 85 21 , , , cord-274510-fo7p98np 85 22 oral oral JJ cord-274510-fo7p98np 85 23 administration administration NN cord-274510-fo7p98np 85 24 should should MD cord-274510-fo7p98np 85 25 be be VB cord-274510-fo7p98np 85 26 preferred prefer VBN cord-274510-fo7p98np 85 27 to to IN cord-274510-fo7p98np 85 28 all all PDT cord-274510-fo7p98np 85 29 the the DT cord-274510-fo7p98np 85 30 other other JJ cord-274510-fo7p98np 85 31 ones one NNS cord-274510-fo7p98np 85 32 . . . cord-274510-fo7p98np 86 1 Although although IN cord-274510-fo7p98np 86 2 the the DT cord-274510-fo7p98np 86 3 administration administration NN cord-274510-fo7p98np 86 4 of of IN cord-274510-fo7p98np 86 5 GcMAF GcMAF NNP cord-274510-fo7p98np 86 6 is be VBZ cord-274510-fo7p98np 86 7 a a DT cord-274510-fo7p98np 86 8 yet yet RB cord-274510-fo7p98np 86 9 an an DT cord-274510-fo7p98np 86 10 unapproved unapproved JJ cord-274510-fo7p98np 86 11 therapy therapy NN cord-274510-fo7p98np 86 12 , , , cord-274510-fo7p98np 86 13 data datum NNS cord-274510-fo7p98np 86 14 from from IN cord-274510-fo7p98np 86 15 previous previous JJ cord-274510-fo7p98np 86 16 studies study NNS cord-274510-fo7p98np 86 17 and and CC cord-274510-fo7p98np 86 18 clinical clinical JJ cord-274510-fo7p98np 86 19 practice practice NN cord-274510-fo7p98np 86 20 reported report VBD cord-274510-fo7p98np 86 21 its -PRON- PRP$ cord-274510-fo7p98np 86 22 effectiveness effectiveness NN cord-274510-fo7p98np 86 23 in in IN cord-274510-fo7p98np 86 24 the the DT cord-274510-fo7p98np 86 25 treatment treatment NN cord-274510-fo7p98np 86 26 of of IN cord-274510-fo7p98np 86 27 many many JJ cord-274510-fo7p98np 86 28 pathologies pathology NNS cord-274510-fo7p98np 86 29 such such JJ cord-274510-fo7p98np 86 30 as as IN cord-274510-fo7p98np 86 31 HIV HIV NNP cord-274510-fo7p98np 86 32 infection infection NN cord-274510-fo7p98np 86 33 [ [ -LRB- cord-274510-fo7p98np 86 34 56 56 CD cord-274510-fo7p98np 86 35 ] ] -RRB- cord-274510-fo7p98np 86 36 and and CC cord-274510-fo7p98np 86 37 other other JJ cord-274510-fo7p98np 86 38 infectious infectious JJ cord-274510-fo7p98np 86 39 diseases disease NNS cord-274510-fo7p98np 86 40 [ [ -LRB- cord-274510-fo7p98np 86 41 54 54 CD cord-274510-fo7p98np 86 42 ] ] -RRB- cord-274510-fo7p98np 86 43 , , , cord-274510-fo7p98np 86 44 some some DT cord-274510-fo7p98np 86 45 types type NNS cord-274510-fo7p98np 86 46 of of IN cord-274510-fo7p98np 86 47 cancer cancer NN cord-274510-fo7p98np 86 48 [ [ -LRB- cord-274510-fo7p98np 86 49 57 57 CD cord-274510-fo7p98np 86 50 ] ] -RRB- cord-274510-fo7p98np 86 51 [ [ -LRB- cord-274510-fo7p98np 86 52 58 58 CD cord-274510-fo7p98np 86 53 ] ] -RRB- cord-274510-fo7p98np 86 54 [ [ -LRB- cord-274510-fo7p98np 86 55 59 59 CD cord-274510-fo7p98np 86 56 ] ] -RRB- cord-274510-fo7p98np 86 57 [ [ -LRB- cord-274510-fo7p98np 86 58 60 60 CD cord-274510-fo7p98np 86 59 ] ] -RRB- cord-274510-fo7p98np 86 60 [ [ -LRB- cord-274510-fo7p98np 86 61 61 61 CD cord-274510-fo7p98np 86 62 ] ] -RRB- cord-274510-fo7p98np 86 63 , , , cord-274510-fo7p98np 86 64 juvenile juvenile JJ cord-274510-fo7p98np 86 65 osteopetrosis osteopetrosis NN cord-274510-fo7p98np 86 66 [ [ -LRB- cord-274510-fo7p98np 86 67 62 62 CD cord-274510-fo7p98np 86 68 ] ] -RRB- cord-274510-fo7p98np 86 69 , , , cord-274510-fo7p98np 86 70 immunological immunological JJ cord-274510-fo7p98np 86 71 ( ( -LRB- cord-274510-fo7p98np 86 72 systemic systemic JJ cord-274510-fo7p98np 86 73 erythematous erythematous JJ cord-274510-fo7p98np 86 74 lupus lupus NN cord-274510-fo7p98np 86 75 ) ) -RRB- cord-274510-fo7p98np 86 76 [ [ -LRB- cord-274510-fo7p98np 86 77 63 63 CD cord-274510-fo7p98np 86 78 ] ] -RRB- cord-274510-fo7p98np 86 79 and and CC cord-274510-fo7p98np 86 80 neurological neurological JJ cord-274510-fo7p98np 86 81 ( ( -LRB- cord-274510-fo7p98np 87 1 multiple multiple JJ cord-274510-fo7p98np 87 2 sclerosis sclerosis NN cord-274510-fo7p98np 87 3 , , , cord-274510-fo7p98np 87 4 autism autism NN cord-274510-fo7p98np 87 5 ) ) -RRB- cord-274510-fo7p98np 87 6 diseases disease NNS cord-274510-fo7p98np 87 7 [ [ -LRB- cord-274510-fo7p98np 87 8 58 58 CD cord-274510-fo7p98np 87 9 , , , cord-274510-fo7p98np 87 10 [ [ -LRB- cord-274510-fo7p98np 87 11 64 64 CD cord-274510-fo7p98np 87 12 ] ] -RRB- cord-274510-fo7p98np 87 13 [ [ -LRB- cord-274510-fo7p98np 87 14 65 65 CD cord-274510-fo7p98np 87 15 ] ] -RRB- cord-274510-fo7p98np 87 16 . . . cord-274510-fo7p98np 88 1 In in IN cord-274510-fo7p98np 88 2 the the DT cord-274510-fo7p98np 88 3 same same JJ cord-274510-fo7p98np 88 4 conditions condition NNS cord-274510-fo7p98np 88 5 , , , cord-274510-fo7p98np 88 6 it -PRON- PRP cord-274510-fo7p98np 88 7 was be VBD cord-274510-fo7p98np 88 8 found find VBN cord-274510-fo7p98np 88 9 an an DT cord-274510-fo7p98np 88 10 inverse inverse JJ cord-274510-fo7p98np 88 11 correlation correlation NN cord-274510-fo7p98np 88 12 between between IN cord-274510-fo7p98np 88 13 the the DT cord-274510-fo7p98np 88 14 MAF MAF NNP cord-274510-fo7p98np 88 15 precursor precursor NN cord-274510-fo7p98np 88 16 activity activity NN cord-274510-fo7p98np 88 17 and and CC cord-274510-fo7p98np 88 18 serum serum NN cord-274510-fo7p98np 88 19 levels level NNS cord-274510-fo7p98np 88 20 of of IN cord-274510-fo7p98np 88 21 nagalase nagalase NN cord-274510-fo7p98np 88 22 ( ( -LRB- cord-274510-fo7p98np 88 23 reference reference NN cord-274510-fo7p98np 88 24 ranges range VBZ cord-274510-fo7p98np 88 25 from from IN cord-274510-fo7p98np 88 26 0,32 0,32 CD cord-274510-fo7p98np 88 27 to to IN cord-274510-fo7p98np 88 28 0,65 0,65 CD cord-274510-fo7p98np 88 29 - - HYPH cord-274510-fo7p98np 88 30 0,95 0,95 CD cord-274510-fo7p98np 88 31 nM nM NNP cord-274510-fo7p98np 88 32 / / SYM cord-274510-fo7p98np 88 33 min min NNP cord-274510-fo7p98np 88 34 / / SYM cord-274510-fo7p98np 88 35 ng ng NNP cord-274510-fo7p98np 88 36 ) ) -RRB- cord-274510-fo7p98np 88 37 , , , cord-274510-fo7p98np 88 38 therefore therefore RB cord-274510-fo7p98np 88 39 showing show VBG cord-274510-fo7p98np 88 40 to to TO cord-274510-fo7p98np 88 41 be be VB cord-274510-fo7p98np 88 42 other other JJ cord-274510-fo7p98np 88 43 than than IN cord-274510-fo7p98np 88 44 pathogenicity pathogenicity NN cord-274510-fo7p98np 88 45 or or CC cord-274510-fo7p98np 88 46 cancer cancer NN cord-274510-fo7p98np 88 47 biomarkers biomarker NNS cord-274510-fo7p98np 88 48 , , , cord-274510-fo7p98np 88 49 also also RB cord-274510-fo7p98np 88 50 good good JJ cord-274510-fo7p98np 88 51 prognosticators prognosticator NNS cord-274510-fo7p98np 88 52 of of IN cord-274510-fo7p98np 88 53 illness illness NN cord-274510-fo7p98np 88 54 and and CC cord-274510-fo7p98np 88 55 response response NN cord-274510-fo7p98np 88 56 to to IN cord-274510-fo7p98np 88 57 therapy therapy NN cord-274510-fo7p98np 88 58 [ [ -LRB- cord-274510-fo7p98np 88 59 55 55 CD cord-274510-fo7p98np 88 60 ] ] -RRB- cord-274510-fo7p98np 88 61 [ [ -LRB- cord-274510-fo7p98np 88 62 56 56 CD cord-274510-fo7p98np 88 63 ] ] -RRB- cord-274510-fo7p98np 88 64 [ [ -LRB- cord-274510-fo7p98np 88 65 57 57 CD cord-274510-fo7p98np 88 66 ] ] -RRB- cord-274510-fo7p98np 88 67 [ [ -LRB- cord-274510-fo7p98np 88 68 58 58 CD cord-274510-fo7p98np 88 69 ] ] -RRB- cord-274510-fo7p98np 88 70 [ [ -LRB- cord-274510-fo7p98np 88 71 59 59 CD cord-274510-fo7p98np 88 72 ] ] -RRB- cord-274510-fo7p98np 88 73 [ [ -LRB- cord-274510-fo7p98np 88 74 60 60 CD cord-274510-fo7p98np 88 75 ] ] -RRB- cord-274510-fo7p98np 88 76 [ [ -LRB- cord-274510-fo7p98np 88 77 61 61 CD cord-274510-fo7p98np 88 78 ] ] -RRB- cord-274510-fo7p98np 88 79 [ [ -LRB- cord-274510-fo7p98np 88 80 62 62 CD cord-274510-fo7p98np 88 81 ] ] -RRB- cord-274510-fo7p98np 88 82 [ [ -LRB- cord-274510-fo7p98np 88 83 63 63 CD cord-274510-fo7p98np 88 84 ] ] -RRB- cord-274510-fo7p98np 88 85 [ [ -LRB- cord-274510-fo7p98np 88 86 64 64 CD cord-274510-fo7p98np 88 87 ] ] -RRB- cord-274510-fo7p98np 88 88 [ [ -LRB- cord-274510-fo7p98np 88 89 65 65 CD cord-274510-fo7p98np 88 90 ] ] -RRB- cord-274510-fo7p98np 88 91 . . . cord-274510-fo7p98np 89 1 However however RB cord-274510-fo7p98np 89 2 , , , cord-274510-fo7p98np 89 3 it -PRON- PRP cord-274510-fo7p98np 89 4 's be VBZ cord-274510-fo7p98np 89 5 clear clear JJ cord-274510-fo7p98np 89 6 that that IN cord-274510-fo7p98np 89 7 only only RB cord-274510-fo7p98np 89 8 well well RB cord-274510-fo7p98np 89 9 - - HYPH cord-274510-fo7p98np 89 10 designed design VBN cord-274510-fo7p98np 89 11 clinical clinical JJ cord-274510-fo7p98np 89 12 trials trial NNS cord-274510-fo7p98np 89 13 will will MD cord-274510-fo7p98np 89 14 be be VB cord-274510-fo7p98np 89 15 able able JJ cord-274510-fo7p98np 89 16 to to TO cord-274510-fo7p98np 89 17 properly properly RB cord-274510-fo7p98np 89 18 evaluate evaluate VB cord-274510-fo7p98np 89 19 the the DT cord-274510-fo7p98np 89 20 therapeutic therapeutic JJ cord-274510-fo7p98np 89 21 use use NN cord-274510-fo7p98np 89 22 of of IN cord-274510-fo7p98np 89 23 GcMAF GcMAF NNP cord-274510-fo7p98np 89 24 . . . cord-274510-fo7p98np 90 1 The the DT cord-274510-fo7p98np 90 2 main main JJ cord-274510-fo7p98np 90 3 targets target NNS cord-274510-fo7p98np 90 4 of of IN cord-274510-fo7p98np 90 5 the the DT cord-274510-fo7p98np 90 6 pharmacologic pharmacologic JJ cord-274510-fo7p98np 90 7 approaches approach NNS cord-274510-fo7p98np 90 8 to to TO cord-274510-fo7p98np 90 9 COVID-19 covid-19 VB cord-274510-fo7p98np 90 10 , , , cord-274510-fo7p98np 90 11 especially especially RB cord-274510-fo7p98np 90 12 for for IN cord-274510-fo7p98np 90 13 the the DT cord-274510-fo7p98np 90 14 complicated complicated JJ cord-274510-fo7p98np 90 15 cases case NNS cord-274510-fo7p98np 90 16 , , , cord-274510-fo7p98np 90 17 are be VBP cord-274510-fo7p98np 90 18 addressed address VBN cord-274510-fo7p98np 90 19 to to TO cord-274510-fo7p98np 90 20 modulate modulate VB cord-274510-fo7p98np 90 21 the the DT cord-274510-fo7p98np 90 22 immune immune JJ cord-274510-fo7p98np 90 23 system system NN cord-274510-fo7p98np 90 24 and and CC cord-274510-fo7p98np 90 25 counteract counteract VB cord-274510-fo7p98np 90 26 the the DT cord-274510-fo7p98np 90 27 overwhelming overwhelming JJ cord-274510-fo7p98np 90 28 inflammation inflammation NN cord-274510-fo7p98np 90 29 . . . cord-274510-fo7p98np 91 1 Notably notably RB cord-274510-fo7p98np 91 2 , , , cord-274510-fo7p98np 91 3 the the DT cord-274510-fo7p98np 91 4 mechanisms mechanism NNS cord-274510-fo7p98np 91 5 we -PRON- PRP cord-274510-fo7p98np 91 6 have have VBP cord-274510-fo7p98np 91 7 hypothesized hypothesize VBN cord-274510-fo7p98np 91 8 about about IN cord-274510-fo7p98np 91 9 the the DT cord-274510-fo7p98np 91 10 possible possible JJ cord-274510-fo7p98np 91 11 pathogenesis pathogenesis NN cord-274510-fo7p98np 91 12 of of IN cord-274510-fo7p98np 91 13 the the DT cord-274510-fo7p98np 91 14 cell cell NN cord-274510-fo7p98np 91 15 and and CC cord-274510-fo7p98np 91 16 tissue tissue NN cord-274510-fo7p98np 91 17 damage damage NN cord-274510-fo7p98np 91 18 induced induce VBN cord-274510-fo7p98np 91 19 by by IN cord-274510-fo7p98np 91 20 SARS SARS NNP cord-274510-fo7p98np 91 21 - - HYPH cord-274510-fo7p98np 91 22 CoV-2 CoV-2 NNP cord-274510-fo7p98np 91 23 seem seem VBP cord-274510-fo7p98np 91 24 to to TO cord-274510-fo7p98np 91 25 provide provide VB cord-274510-fo7p98np 91 26 a a DT cord-274510-fo7p98np 91 27 common common JJ cord-274510-fo7p98np 91 28 denominator denominator NN cord-274510-fo7p98np 91 29 in in IN cord-274510-fo7p98np 91 30 explaining explain VBG cord-274510-fo7p98np 91 31 the the DT cord-274510-fo7p98np 91 32 effects effect NNS cord-274510-fo7p98np 91 33 of of IN cord-274510-fo7p98np 91 34 most most JJS cord-274510-fo7p98np 91 35 drugs drug NNS cord-274510-fo7p98np 91 36 currently currently RB cord-274510-fo7p98np 91 37 considered consider VBN cord-274510-fo7p98np 91 38 for for IN cord-274510-fo7p98np 91 39 the the DT cord-274510-fo7p98np 91 40 treatment treatment NN cord-274510-fo7p98np 91 41 of of IN cord-274510-fo7p98np 91 42 COVID-19 COVID-19 NNP cord-274510-fo7p98np 91 43 : : : cord-274510-fo7p98np 91 44 these these DT cord-274510-fo7p98np 91 45 include include VBP cord-274510-fo7p98np 91 46 antivirals antiviral NNS cord-274510-fo7p98np 91 47 ( ( -LRB- cord-274510-fo7p98np 91 48 i.e. i.e. FW cord-274510-fo7p98np 91 49 remdesivir remdesivir NNP cord-274510-fo7p98np 91 50 , , , cord-274510-fo7p98np 91 51 lopinavir lopinavir NNP cord-274510-fo7p98np 91 52 / / SYM cord-274510-fo7p98np 91 53 ritonavir ritonavir NNP cord-274510-fo7p98np 91 54 , , , cord-274510-fo7p98np 91 55 darunavir darunavir NNP cord-274510-fo7p98np 91 56 , , , cord-274510-fo7p98np 91 57 cobicistat cobicistat NNP cord-274510-fo7p98np 91 58 ) ) -RRB- cord-274510-fo7p98np 91 59 and and CC cord-274510-fo7p98np 91 60 immunomodulating immunomodulating JJ cord-274510-fo7p98np 91 61 and/or and/or CC cord-274510-fo7p98np 91 62 antiinflammatory antiinflammatory JJ cord-274510-fo7p98np 91 63 drugs drug NNS cord-274510-fo7p98np 91 64 [ [ -LRB- cord-274510-fo7p98np 91 65 66 66 CD cord-274510-fo7p98np 91 66 ] ] -RRB- cord-274510-fo7p98np 91 67 [ [ -LRB- cord-274510-fo7p98np 91 68 67 67 CD cord-274510-fo7p98np 91 69 ] ] -RRB- cord-274510-fo7p98np 91 70 . . . cord-274510-fo7p98np 92 1 In in IN cord-274510-fo7p98np 92 2 particular particular JJ cord-274510-fo7p98np 92 3 , , , cord-274510-fo7p98np 92 4 based base VBN cord-274510-fo7p98np 92 5 on on IN cord-274510-fo7p98np 92 6 their -PRON- PRP$ cord-274510-fo7p98np 92 7 antiviral antiviral JJ cord-274510-fo7p98np 92 8 activity activity NN cord-274510-fo7p98np 92 9 [ [ -LRB- cord-274510-fo7p98np 92 10 68 68 CD cord-274510-fo7p98np 92 11 ] ] -RRB- cord-274510-fo7p98np 92 12 , , , cord-274510-fo7p98np 92 13 chloroquine chloroquine NNP cord-274510-fo7p98np 92 14 and and CC cord-274510-fo7p98np 92 15 hydroxychloroquine hydroxychloroquine NN cord-274510-fo7p98np 92 16 , , , cord-274510-fo7p98np 92 17 initially initially RB cord-274510-fo7p98np 92 18 conceived conceive VBN cord-274510-fo7p98np 92 19 as as IN cord-274510-fo7p98np 92 20 antimalarial antimalarial JJ cord-274510-fo7p98np 92 21 therapeutics therapeutic NNS cord-274510-fo7p98np 92 22 , , , cord-274510-fo7p98np 92 23 were be VBD cord-274510-fo7p98np 92 24 proposed propose VBN cord-274510-fo7p98np 92 25 to to TO cord-274510-fo7p98np 92 26 treat treat VB cord-274510-fo7p98np 92 27 patients patient NNS cord-274510-fo7p98np 92 28 hospitalized hospitalize VBN cord-274510-fo7p98np 92 29 with with IN cord-274510-fo7p98np 92 30 COVID-19 COVID-19 NNP cord-274510-fo7p98np 92 31 , , , cord-274510-fo7p98np 92 32 better well RBR cord-274510-fo7p98np 92 33 if if IN cord-274510-fo7p98np 92 34 associated associate VBN cord-274510-fo7p98np 92 35 to to IN cord-274510-fo7p98np 92 36 azithromycin azithromycin NNP cord-274510-fo7p98np 92 37 , , , cord-274510-fo7p98np 92 38 showing show VBG cord-274510-fo7p98np 92 39 promising promising JJ cord-274510-fo7p98np 92 40 efficacy efficacy NN cord-274510-fo7p98np 92 41 in in IN cord-274510-fo7p98np 92 42 " " `` cord-274510-fo7p98np 92 43 inhibiting inhibit VBG cord-274510-fo7p98np 92 44 the the DT cord-274510-fo7p98np 92 45 exacerbation exacerbation NN cord-274510-fo7p98np 92 46 of of IN cord-274510-fo7p98np 92 47 pneumonia pneumonia NN cord-274510-fo7p98np 92 48 , , , cord-274510-fo7p98np 92 49 improving improve VBG cord-274510-fo7p98np 92 50 lung lung NN cord-274510-fo7p98np 92 51 imaging imaging NN cord-274510-fo7p98np 92 52 findings finding NNS cord-274510-fo7p98np 92 53 , , , cord-274510-fo7p98np 92 54 promoting promote VBG cord-274510-fo7p98np 92 55 a a DT cord-274510-fo7p98np 92 56 virus virus NN cord-274510-fo7p98np 92 57 negative negative JJ cord-274510-fo7p98np 92 58 conversion conversion NN cord-274510-fo7p98np 92 59 and and CC cord-274510-fo7p98np 92 60 shortening shorten VBG cord-274510-fo7p98np 92 61 the the DT cord-274510-fo7p98np 92 62 disease disease NN cord-274510-fo7p98np 92 63 course course NN cord-274510-fo7p98np 92 64 " " '' cord-274510-fo7p98np 92 65 [ [ -LRB- cord-274510-fo7p98np 92 66 69 69 CD cord-274510-fo7p98np 92 67 ] ] -RRB- cord-274510-fo7p98np 92 68 [ [ -LRB- cord-274510-fo7p98np 92 69 70 70 CD cord-274510-fo7p98np 92 70 ] ] -RRB- cord-274510-fo7p98np 92 71 . . . cord-274510-fo7p98np 93 1 On on IN cord-274510-fo7p98np 93 2 the the DT cord-274510-fo7p98np 93 3 other other JJ cord-274510-fo7p98np 93 4 hand hand NN cord-274510-fo7p98np 93 5 , , , cord-274510-fo7p98np 93 6 hydroxychloroquine hydroxychloroquine NNP cord-274510-fo7p98np 93 7 is be VBZ cord-274510-fo7p98np 93 8 the the DT cord-274510-fo7p98np 93 9 cornerstone cornerstone NN cord-274510-fo7p98np 93 10 of of IN cord-274510-fo7p98np 93 11 medical medical JJ cord-274510-fo7p98np 93 12 therapy therapy NN cord-274510-fo7p98np 93 13 in in IN cord-274510-fo7p98np 93 14 lupus lupus NN cord-274510-fo7p98np 93 15 , , , cord-274510-fo7p98np 93 16 where where WRB cord-274510-fo7p98np 93 17 it -PRON- PRP cord-274510-fo7p98np 93 18 acts act VBZ cord-274510-fo7p98np 93 19 as as IN cord-274510-fo7p98np 93 20 an an DT cord-274510-fo7p98np 93 21 immunomodulatory immunomodulatory NN cord-274510-fo7p98np 93 22 without without IN cord-274510-fo7p98np 93 23 immunosuppressive immunosuppressive JJ cord-274510-fo7p98np 93 24 effects effect NNS cord-274510-fo7p98np 93 25 [ [ -LRB- cord-274510-fo7p98np 93 26 71 71 CD cord-274510-fo7p98np 93 27 ] ] -RRB- cord-274510-fo7p98np 93 28 . . . cord-274510-fo7p98np 94 1 However however RB cord-274510-fo7p98np 94 2 , , , cord-274510-fo7p98np 94 3 in in IN cord-274510-fo7p98np 94 4 light light NN cord-274510-fo7p98np 94 5 of of IN cord-274510-fo7p98np 94 6 ongoing ongoing JJ cord-274510-fo7p98np 94 7 serious serious JJ cord-274510-fo7p98np 94 8 cardiac cardiac JJ cord-274510-fo7p98np 94 9 adverse adverse JJ cord-274510-fo7p98np 94 10 events event NNS cord-274510-fo7p98np 94 11 [ [ -LRB- cord-274510-fo7p98np 94 12 72 72 CD cord-274510-fo7p98np 94 13 ] ] -RRB- cord-274510-fo7p98np 94 14 and and CC cord-274510-fo7p98np 94 15 other other JJ cord-274510-fo7p98np 94 16 serious serious JJ cord-274510-fo7p98np 94 17 side side NN cord-274510-fo7p98np 94 18 effects effect NNS cord-274510-fo7p98np 94 19 , , , cord-274510-fo7p98np 94 20 the the DT cord-274510-fo7p98np 94 21 known known JJ cord-274510-fo7p98np 94 22 and and CC cord-274510-fo7p98np 94 23 potential potential JJ cord-274510-fo7p98np 94 24 benefits benefit NNS cord-274510-fo7p98np 94 25 of of IN cord-274510-fo7p98np 94 26 chloroquine chloroquine NN cord-274510-fo7p98np 94 27 and and CC cord-274510-fo7p98np 94 28 hydroxychloroquine hydroxychloroquine VBP cord-274510-fo7p98np 94 29 no no RB cord-274510-fo7p98np 94 30 longer long RBR cord-274510-fo7p98np 94 31 outweigh outweigh VB cord-274510-fo7p98np 94 32 the the DT cord-274510-fo7p98np 94 33 known known JJ cord-274510-fo7p98np 94 34 and and CC cord-274510-fo7p98np 94 35 potential potential JJ cord-274510-fo7p98np 94 36 risks risk NNS cord-274510-fo7p98np 94 37 for for IN cord-274510-fo7p98np 94 38 the the DT cord-274510-fo7p98np 94 39 authorized authorize VBN cord-274510-fo7p98np 94 40 use use NN cord-274510-fo7p98np 94 41 in in IN cord-274510-fo7p98np 94 42 COVID-19 COVID-19 NNP cord-274510-fo7p98np 94 43 patients patient NNS cord-274510-fo7p98np 94 44 . . . cord-274510-fo7p98np 95 1 In in IN cord-274510-fo7p98np 95 2 addition addition NN cord-274510-fo7p98np 95 3 , , , cord-274510-fo7p98np 95 4 the the DT cord-274510-fo7p98np 95 5 COVID- covid- NN cord-274510-fo7p98np 95 6 Tocilizumab Tocilizumab NNP cord-274510-fo7p98np 95 7 , , , cord-274510-fo7p98np 95 8 an an DT cord-274510-fo7p98np 95 9 IL-6 IL-6 NNP cord-274510-fo7p98np 95 10 antagonist antagonist NN cord-274510-fo7p98np 95 11 , , , cord-274510-fo7p98np 95 12 approved approve VBN cord-274510-fo7p98np 95 13 for for IN cord-274510-fo7p98np 95 14 the the DT cord-274510-fo7p98np 95 15 treatment treatment NN cord-274510-fo7p98np 95 16 of of IN cord-274510-fo7p98np 95 17 rheumatoid rheumatoid JJ cord-274510-fo7p98np 95 18 arthritis arthritis NN cord-274510-fo7p98np 95 19 and and CC cord-274510-fo7p98np 95 20 juvenile juvenile JJ cord-274510-fo7p98np 95 21 idiopathic idiopathic JJ cord-274510-fo7p98np 95 22 arthritis arthritis NN cord-274510-fo7p98np 95 23 , , , cord-274510-fo7p98np 95 24 also also RB cord-274510-fo7p98np 95 25 had have VBD cord-274510-fo7p98np 95 26 therapeutic therapeutic JJ cord-274510-fo7p98np 95 27 application application NN cord-274510-fo7p98np 95 28 in in IN cord-274510-fo7p98np 95 29 critical critical JJ cord-274510-fo7p98np 95 30 COVID-19 COVID-19 NNP cord-274510-fo7p98np 95 31 patients patient NNS cord-274510-fo7p98np 95 32 , , , cord-274510-fo7p98np 95 33 providing provide VBG cord-274510-fo7p98np 95 34 encouraging encouraging JJ cord-274510-fo7p98np 95 35 results result NNS cord-274510-fo7p98np 95 36 [ [ -LRB- cord-274510-fo7p98np 95 37 74 74 CD cord-274510-fo7p98np 95 38 ] ] -RRB- cord-274510-fo7p98np 95 39 . . . cord-274510-fo7p98np 96 1 However however RB cord-274510-fo7p98np 96 2 , , , cord-274510-fo7p98np 96 3 the the DT cord-274510-fo7p98np 96 4 phase phase NN cord-274510-fo7p98np 96 5 III iii CD cord-274510-fo7p98np 96 6 clinical clinical JJ cord-274510-fo7p98np 96 7 trial trial NN cord-274510-fo7p98np 96 8 ( ( -LRB- cord-274510-fo7p98np 96 9 COVACTA COVACTA NNP cord-274510-fo7p98np 96 10 ) ) -RRB- cord-274510-fo7p98np 96 11 [ [ -LRB- cord-274510-fo7p98np 96 12 75 75 CD cord-274510-fo7p98np 96 13 ] ] -RRB- cord-274510-fo7p98np 96 14 for for IN cord-274510-fo7p98np 96 15 evaluating evaluate VBG cord-274510-fo7p98np 96 16 tocilizumab tocilizumab NNP cord-274510-fo7p98np 96 17 in in IN cord-274510-fo7p98np 96 18 hospitalized hospitalize VBN cord-274510-fo7p98np 96 19 patients patient NNS cord-274510-fo7p98np 96 20 with with IN cord-274510-fo7p98np 96 21 severe severe JJ cord-274510-fo7p98np 96 22 COVID-19 covid-19 JJ cord-274510-fo7p98np 96 23 pneumonia pneumonia NN cord-274510-fo7p98np 96 24 found find VBD cord-274510-fo7p98np 96 25 no no DT cord-274510-fo7p98np 96 26 difference difference NN cord-274510-fo7p98np 96 27 between between IN cord-274510-fo7p98np 96 28 tocilizumab tocilizumab NNP cord-274510-fo7p98np 96 29 versus versus IN cord-274510-fo7p98np 96 30 placebo placebo NN cord-274510-fo7p98np 96 31 in in IN cord-274510-fo7p98np 96 32 intensive intensive JJ cord-274510-fo7p98np 96 33 care care NN cord-274510-fo7p98np 96 34 requirements requirement NNS cord-274510-fo7p98np 96 35 or or CC cord-274510-fo7p98np 96 36 mortality mortality NN cord-274510-fo7p98np 96 37 . . . cord-274510-fo7p98np 97 1 Therefore therefore RB cord-274510-fo7p98np 97 2 , , , cord-274510-fo7p98np 97 3 there there EX cord-274510-fo7p98np 97 4 are be VBP cord-274510-fo7p98np 97 5 insufficient insufficient JJ cord-274510-fo7p98np 97 6 data datum NNS cord-274510-fo7p98np 97 7 for for IN cord-274510-fo7p98np 97 8 the the DT cord-274510-fo7p98np 97 9 Panel Panel NNP cord-274510-fo7p98np 97 10 to to TO cord-274510-fo7p98np 97 11 recommend recommend VB cord-274510-fo7p98np 97 12 either either CC cord-274510-fo7p98np 97 13 for for IN cord-274510-fo7p98np 97 14 or or CC cord-274510-fo7p98np 97 15 against against IN cord-274510-fo7p98np 97 16 the the DT cord-274510-fo7p98np 97 17 use use NN cord-274510-fo7p98np 97 18 of of IN cord-274510-fo7p98np 97 19 the the DT cord-274510-fo7p98np 97 20 IL-6 IL-6 NNP cord-274510-fo7p98np 97 21 inhibitors inhibitor NNS cord-274510-fo7p98np 97 22 for for IN cord-274510-fo7p98np 97 23 the the DT cord-274510-fo7p98np 97 24 treatment treatment NN cord-274510-fo7p98np 97 25 of of IN cord-274510-fo7p98np 97 26 COVID- covid- NN cord-274510-fo7p98np 97 27 19 19 CD cord-274510-fo7p98np 97 28 [ [ -LRB- cord-274510-fo7p98np 97 29 73 73 CD cord-274510-fo7p98np 97 30 ] ] -RRB- cord-274510-fo7p98np 97 31 . . . cord-274510-fo7p98np 98 1 The the DT cord-274510-fo7p98np 98 2 rationale rationale NN cord-274510-fo7p98np 98 3 basis basis NN cord-274510-fo7p98np 98 4 for for IN cord-274510-fo7p98np 98 5 the the DT cord-274510-fo7p98np 98 6 use use NN cord-274510-fo7p98np 98 7 of of IN cord-274510-fo7p98np 98 8 monoclonal monoclonal JJ cord-274510-fo7p98np 98 9 antibodies antibody NNS cord-274510-fo7p98np 98 10 in in IN cord-274510-fo7p98np 98 11 patients patient NNS cord-274510-fo7p98np 98 12 affected affect VBN cord-274510-fo7p98np 98 13 by by IN cord-274510-fo7p98np 98 14 SARS SARS NNP cord-274510-fo7p98np 98 15 - - HYPH cord-274510-fo7p98np 98 16 CoV-2 CoV-2 NNP cord-274510-fo7p98np 98 17 seems seem VBZ cord-274510-fo7p98np 98 18 to to TO cord-274510-fo7p98np 98 19 lie lie VB cord-274510-fo7p98np 98 20 in in IN cord-274510-fo7p98np 98 21 the the DT cord-274510-fo7p98np 98 22 so so RB cord-274510-fo7p98np 98 23 - - HYPH cord-274510-fo7p98np 98 24 called call VBN cord-274510-fo7p98np 98 25 systemic systemic JJ cord-274510-fo7p98np 98 26 cytokine cytokine NN cord-274510-fo7p98np 98 27 storm storm NN cord-274510-fo7p98np 98 28 . . . cord-274510-fo7p98np 99 1 Taking take VBG cord-274510-fo7p98np 99 2 into into IN cord-274510-fo7p98np 99 3 account account NN cord-274510-fo7p98np 99 4 the the DT cord-274510-fo7p98np 99 5 key key JJ cord-274510-fo7p98np 99 6 role role NN cord-274510-fo7p98np 99 7 of of IN cord-274510-fo7p98np 99 8 VEGF VEGF NNP cord-274510-fo7p98np 99 9 in in IN cord-274510-fo7p98np 99 10 enhancing enhance VBG cord-274510-fo7p98np 99 11 angiogenesis angiogenesis NN cord-274510-fo7p98np 99 12 in in IN cord-274510-fo7p98np 99 13 acute acute JJ cord-274510-fo7p98np 99 14 lung lung NN cord-274510-fo7p98np 99 15 injury injury NN cord-274510-fo7p98np 99 16 and and CC cord-274510-fo7p98np 99 17 ARDS ARDS NNP cord-274510-fo7p98np 99 18 [ [ -LRB- cord-274510-fo7p98np 99 19 76 76 CD cord-274510-fo7p98np 99 20 ] ] -RRB- cord-274510-fo7p98np 99 21 , , , cord-274510-fo7p98np 99 22 two two CD cord-274510-fo7p98np 99 23 trials trial NNS cord-274510-fo7p98np 99 24 , , , cord-274510-fo7p98np 99 25 evaluating evaluate VBG cord-274510-fo7p98np 99 26 the the DT cord-274510-fo7p98np 99 27 efficacy efficacy NN cord-274510-fo7p98np 99 28 of of IN cord-274510-fo7p98np 99 29 bevacizumab bevacizumab NNP cord-274510-fo7p98np 99 30 as as IN cord-274510-fo7p98np 99 31 VEGF VEGF NNP cord-274510-fo7p98np 99 32 antagonist antagonist NN cord-274510-fo7p98np 99 33 in in IN cord-274510-fo7p98np 99 34 the the DT cord-274510-fo7p98np 99 35 treatment treatment NN cord-274510-fo7p98np 99 36 of of IN cord-274510-fo7p98np 99 37 COVID-19 covid-19 JJ cord-274510-fo7p98np 99 38 ( ( -LRB- cord-274510-fo7p98np 99 39 BEST best JJ cord-274510-fo7p98np 99 40 - - HYPH cord-274510-fo7p98np 99 41 PC pc NN cord-274510-fo7p98np 99 42 and and CC cord-274510-fo7p98np 99 43 BEST best JJ cord-274510-fo7p98np 99 44 - - HYPH cord-274510-fo7p98np 99 45 RCT RCT NNP cord-274510-fo7p98np 99 46 ) ) -RRB- cord-274510-fo7p98np 99 47 , , , cord-274510-fo7p98np 99 48 were be VBD cord-274510-fo7p98np 99 49 started start VBN cord-274510-fo7p98np 99 50 [ [ -LRB- cord-274510-fo7p98np 99 51 77 77 CD cord-274510-fo7p98np 99 52 ] ] -RRB- cord-274510-fo7p98np 99 53 [ [ -LRB- cord-274510-fo7p98np 99 54 78 78 CD cord-274510-fo7p98np 99 55 ] ] -RRB- cord-274510-fo7p98np 99 56 . . . cord-274510-fo7p98np 100 1 Less Less JJR cord-274510-fo7p98np 100 2 than than IN cord-274510-fo7p98np 100 3 two two CD cord-274510-fo7p98np 100 4 months month NNS cord-274510-fo7p98np 100 5 after after IN cord-274510-fo7p98np 100 6 the the DT cord-274510-fo7p98np 100 7 declaration declaration NN cord-274510-fo7p98np 100 8 of of IN cord-274510-fo7p98np 100 9 pandemic pandemic NNP cord-274510-fo7p98np 100 10 state state NN cord-274510-fo7p98np 100 11 by by IN cord-274510-fo7p98np 100 12 the the DT cord-274510-fo7p98np 100 13 World World NNP cord-274510-fo7p98np 100 14 Health Health NNP cord-274510-fo7p98np 100 15 Organization Organization NNP cord-274510-fo7p98np 100 16 , , , cord-274510-fo7p98np 100 17 every every DT cord-274510-fo7p98np 100 18 effort effort NN cord-274510-fo7p98np 100 19 by by IN cord-274510-fo7p98np 100 20 the the DT cord-274510-fo7p98np 100 21 entire entire JJ cord-274510-fo7p98np 100 22 scientific scientific JJ cord-274510-fo7p98np 100 23 community community NN cord-274510-fo7p98np 100 24 has have VBZ cord-274510-fo7p98np 100 25 been be VBN cord-274510-fo7p98np 100 26 made make VBN cord-274510-fo7p98np 100 27 to to TO cord-274510-fo7p98np 100 28 face face VB cord-274510-fo7p98np 100 29 this this DT cord-274510-fo7p98np 100 30 worldwide worldwide JJ cord-274510-fo7p98np 100 31 emergency emergency NN cord-274510-fo7p98np 100 32 of of IN cord-274510-fo7p98np 100 33 COVID-19 COVID-19 NNP cord-274510-fo7p98np 100 34 in in IN cord-274510-fo7p98np 100 35 the the DT cord-274510-fo7p98np 100 36 best good JJS cord-274510-fo7p98np 100 37 possible possible JJ cord-274510-fo7p98np 100 38 way way NN cord-274510-fo7p98np 100 39 . . . cord-274510-fo7p98np 101 1 However however RB cord-274510-fo7p98np 101 2 , , , cord-274510-fo7p98np 101 3 at at IN cord-274510-fo7p98np 101 4 the the DT cord-274510-fo7p98np 101 5 present present JJ cord-274510-fo7p98np 101 6 days day NNS cord-274510-fo7p98np 101 7 , , , cord-274510-fo7p98np 101 8 the the DT cord-274510-fo7p98np 101 9 underlying underlie VBG cord-274510-fo7p98np 101 10 mechanisms mechanism NNS cord-274510-fo7p98np 101 11 of of IN cord-274510-fo7p98np 101 12 pathophysiology pathophysiology NN cord-274510-fo7p98np 101 13 remain remain VBP cord-274510-fo7p98np 101 14 unknown unknown JJ cord-274510-fo7p98np 101 15 . . . cord-274510-fo7p98np 102 1 Nowadays nowadays RB cord-274510-fo7p98np 102 2 , , , cord-274510-fo7p98np 102 3 although although IN cord-274510-fo7p98np 102 4 a a DT cord-274510-fo7p98np 102 5 number number NN cord-274510-fo7p98np 102 6 of of IN cord-274510-fo7p98np 102 7 preliminary preliminary JJ cord-274510-fo7p98np 102 8 clinical clinical JJ cord-274510-fo7p98np 102 9 trials trial NNS cord-274510-fo7p98np 102 10 are be VBP cord-274510-fo7p98np 102 11 underway underway JJ cord-274510-fo7p98np 102 12 and and CC cord-274510-fo7p98np 102 13 scientific scientific JJ cord-274510-fo7p98np 102 14 evidence evidence NN cord-274510-fo7p98np 102 15 is be VBZ cord-274510-fo7p98np 102 16 growing grow VBG cord-274510-fo7p98np 102 17 on on IN cord-274510-fo7p98np 102 18 this this DT cord-274510-fo7p98np 102 19 topic topic NN cord-274510-fo7p98np 102 20 , , , cord-274510-fo7p98np 102 21 neither neither CC cord-274510-fo7p98np 102 22 specific specific JJ cord-274510-fo7p98np 102 23 drugs drug NNS cord-274510-fo7p98np 102 24 nor nor CC cord-274510-fo7p98np 102 25 effective effective JJ cord-274510-fo7p98np 102 26 preventive preventive JJ cord-274510-fo7p98np 102 27 measures measure NNS cord-274510-fo7p98np 102 28 are be VBP cord-274510-fo7p98np 102 29 yet yet RB cord-274510-fo7p98np 102 30 available available JJ cord-274510-fo7p98np 102 31 for for IN cord-274510-fo7p98np 102 32 the the DT cord-274510-fo7p98np 102 33 treatment treatment NN cord-274510-fo7p98np 102 34 of of IN cord-274510-fo7p98np 102 35 COVID-19 COVID-19 NNP cord-274510-fo7p98np 102 36 . . . cord-274510-fo7p98np 103 1 Anyway anyway UH cord-274510-fo7p98np 103 2 , , , cord-274510-fo7p98np 103 3 it -PRON- PRP cord-274510-fo7p98np 103 4 seems seem VBZ cord-274510-fo7p98np 103 5 we -PRON- PRP cord-274510-fo7p98np 103 6 still still RB cord-274510-fo7p98np 103 7 have have VBP cord-274510-fo7p98np 103 8 a a DT cord-274510-fo7p98np 103 9 great great JJ cord-274510-fo7p98np 103 10 deal deal NN cord-274510-fo7p98np 103 11 of of IN cord-274510-fo7p98np 103 12 work work NN cord-274510-fo7p98np 103 13 to to TO cord-274510-fo7p98np 103 14 find find VB cord-274510-fo7p98np 103 15 the the DT cord-274510-fo7p98np 103 16 " " `` cord-274510-fo7p98np 103 17 miracle miracle NN cord-274510-fo7p98np 103 18 care care NN cord-274510-fo7p98np 103 19 " " '' cord-274510-fo7p98np 103 20 . . . cord-274510-fo7p98np 104 1 However however RB cord-274510-fo7p98np 104 2 , , , cord-274510-fo7p98np 104 3 due due IN cord-274510-fo7p98np 104 4 to to IN cord-274510-fo7p98np 104 5 the the DT cord-274510-fo7p98np 104 6 risk risk NN cord-274510-fo7p98np 104 7 of of IN cord-274510-fo7p98np 104 8 serious serious JJ cord-274510-fo7p98np 104 9 drug drug NN cord-274510-fo7p98np 104 10 - - HYPH cord-274510-fo7p98np 104 11 related relate VBN cord-274510-fo7p98np 104 12 adverse adverse JJ cord-274510-fo7p98np 104 13 events event NNS cord-274510-fo7p98np 104 14 , , , cord-274510-fo7p98np 104 15 the the DT cord-274510-fo7p98np 104 16 immunomodulatory immunomodulatory JJ cord-274510-fo7p98np 104 17 and and CC cord-274510-fo7p98np 104 18 anti anti JJ cord-274510-fo7p98np 104 19 - - JJ cord-274510-fo7p98np 104 20 inflammatory inflammatory JJ cord-274510-fo7p98np 104 21 drugs drug NNS cord-274510-fo7p98np 104 22 currently currently RB cord-274510-fo7p98np 104 23 used use VBN cord-274510-fo7p98np 104 24 for for IN cord-274510-fo7p98np 104 25 COVID-19 COVID-19 NNP cord-274510-fo7p98np 104 26 , , , cord-274510-fo7p98np 104 27 are be VBP cord-274510-fo7p98np 104 28 still still RB cord-274510-fo7p98np 104 29 restricted restrict VBN cord-274510-fo7p98np 104 30 to to IN cord-274510-fo7p98np 104 31 carefully carefully RB cord-274510-fo7p98np 104 32 selected select VBN cord-274510-fo7p98np 104 33 and and CC cord-274510-fo7p98np 104 34 complicated complicated JJ cord-274510-fo7p98np 104 35 cases case NNS cord-274510-fo7p98np 104 36 [ [ -LRB- cord-274510-fo7p98np 104 37 72 72 CD cord-274510-fo7p98np 104 38 , , , cord-274510-fo7p98np 104 39 [ [ -LRB- cord-274510-fo7p98np 104 40 79 79 CD cord-274510-fo7p98np 104 41 ] ] -RRB- cord-274510-fo7p98np 104 42 [ [ -LRB- cord-274510-fo7p98np 104 43 80 80 CD cord-274510-fo7p98np 104 44 ] ] -RRB- cord-274510-fo7p98np 105 1 [ [ -LRB- cord-274510-fo7p98np 105 2 81 81 CD cord-274510-fo7p98np 105 3 ] ] -RRB- cord-274510-fo7p98np 105 4 [ [ -LRB- cord-274510-fo7p98np 105 5 82 82 CD cord-274510-fo7p98np 105 6 ] ] -RRB- cord-274510-fo7p98np 105 7 . . . cord-274510-fo7p98np 106 1 So so RB cord-274510-fo7p98np 106 2 , , , cord-274510-fo7p98np 106 3 in in IN cord-274510-fo7p98np 106 4 sight sight NN cord-274510-fo7p98np 106 5 of of IN cord-274510-fo7p98np 106 6 this this DT cord-274510-fo7p98np 106 7 , , , cord-274510-fo7p98np 106 8 given give VBN cord-274510-fo7p98np 106 9 its -PRON- PRP$ cord-274510-fo7p98np 106 10 multifunctional multifunctional JJ cord-274510-fo7p98np 106 11 properties property NNS cord-274510-fo7p98np 106 12 , , , cord-274510-fo7p98np 106 13 we -PRON- PRP cord-274510-fo7p98np 106 14 believe believe VBP cord-274510-fo7p98np 106 15 that that IN cord-274510-fo7p98np 106 16 GcMAF GcMAF NNP cord-274510-fo7p98np 106 17 could could MD cord-274510-fo7p98np 106 18 have have VB cord-274510-fo7p98np 106 19 a a DT cord-274510-fo7p98np 106 20 very very RB cord-274510-fo7p98np 106 21 important important JJ cord-274510-fo7p98np 106 22 role role NN cord-274510-fo7p98np 106 23 in in IN cord-274510-fo7p98np 106 24 the the DT cord-274510-fo7p98np 106 25 pathophysiology pathophysiology NN cord-274510-fo7p98np 106 26 of of IN cord-274510-fo7p98np 106 27 organ organ NN cord-274510-fo7p98np 106 28 damage damage NN cord-274510-fo7p98np 106 29 induced induce VBN cord-274510-fo7p98np 106 30 by by IN cord-274510-fo7p98np 106 31 SARS SARS NNP cord-274510-fo7p98np 106 32 - - HYPH cord-274510-fo7p98np 106 33 CoV-2 CoV-2 NNP cord-274510-fo7p98np 106 34 , , , cord-274510-fo7p98np 106 35 providing provide VBG cord-274510-fo7p98np 106 36 explanations explanation NNS cord-274510-fo7p98np 106 37 which which WDT cord-274510-fo7p98np 106 38 are be VBP cord-274510-fo7p98np 106 39 consistent consistent JJ cord-274510-fo7p98np 106 40 with with IN cord-274510-fo7p98np 106 41 the the DT cord-274510-fo7p98np 106 42 clinical clinical JJ cord-274510-fo7p98np 106 43 , , , cord-274510-fo7p98np 106 44 radiological radiological JJ cord-274510-fo7p98np 106 45 and and CC cord-274510-fo7p98np 106 46 histopathological histopathological JJ cord-274510-fo7p98np 106 47 findings finding NNS cord-274510-fo7p98np 106 48 observed observe VBD cord-274510-fo7p98np 106 49 in in IN cord-274510-fo7p98np 106 50 patients patient NNS cord-274510-fo7p98np 106 51 with with IN cord-274510-fo7p98np 106 52 COVID-19 COVID-19 NNP cord-274510-fo7p98np 106 53 . . . cord-274510-fo7p98np 107 1 Despite despite IN cord-274510-fo7p98np 107 2 burgeoning burgeon VBG cord-274510-fo7p98np 107 3 data datum NNS cord-274510-fo7p98np 107 4 from from IN cord-274510-fo7p98np 107 5 case case NN cord-274510-fo7p98np 107 6 series series NN cord-274510-fo7p98np 107 7 of of IN cord-274510-fo7p98np 107 8 various various JJ cord-274510-fo7p98np 107 9 pathological pathological JJ cord-274510-fo7p98np 107 10 conditions condition NNS cord-274510-fo7p98np 107 11 demonstrated demonstrate VBD cord-274510-fo7p98np 107 12 the the DT cord-274510-fo7p98np 107 13 potential potential JJ cord-274510-fo7p98np 107 14 clinical clinical JJ cord-274510-fo7p98np 107 15 benefits benefit NNS cord-274510-fo7p98np 107 16 of of IN cord-274510-fo7p98np 107 17 GcMAF GcMAF NNP cord-274510-fo7p98np 108 1 as as IN cord-274510-fo7p98np 108 2 above above RB cord-274510-fo7p98np 108 3 mentioned mention VBD cord-274510-fo7p98np 108 4 [ [ -LRB- cord-274510-fo7p98np 108 5 56 56 CD cord-274510-fo7p98np 108 6 ] ] -RRB- cord-274510-fo7p98np 108 7 [ [ -LRB- cord-274510-fo7p98np 108 8 57 57 CD cord-274510-fo7p98np 108 9 ] ] -RRB- cord-274510-fo7p98np 108 10 [ [ -LRB- cord-274510-fo7p98np 108 11 58 58 CD cord-274510-fo7p98np 108 12 ] ] -RRB- cord-274510-fo7p98np 108 13 [ [ -LRB- cord-274510-fo7p98np 108 14 59 59 CD cord-274510-fo7p98np 108 15 ] ] -RRB- cord-274510-fo7p98np 108 16 [ [ -LRB- cord-274510-fo7p98np 108 17 60 60 CD cord-274510-fo7p98np 108 18 ] ] -RRB- cord-274510-fo7p98np 108 19 [ [ -LRB- cord-274510-fo7p98np 108 20 61 61 CD cord-274510-fo7p98np 108 21 ] ] -RRB- cord-274510-fo7p98np 108 22 [ [ -LRB- cord-274510-fo7p98np 108 23 62 62 CD cord-274510-fo7p98np 108 24 ] ] -RRB- cord-274510-fo7p98np 108 25 [ [ -LRB- cord-274510-fo7p98np 108 26 63 63 CD cord-274510-fo7p98np 108 27 ] ] -RRB- cord-274510-fo7p98np 108 28 [ [ -LRB- cord-274510-fo7p98np 108 29 64 64 CD cord-274510-fo7p98np 108 30 ] ] -RRB- cord-274510-fo7p98np 108 31 [ [ -LRB- cord-274510-fo7p98np 108 32 65 65 CD cord-274510-fo7p98np 108 33 ] ] -RRB- cord-274510-fo7p98np 108 34 , , , cord-274510-fo7p98np 108 35 no no DT cord-274510-fo7p98np 108 36 randomized randomized JJ cord-274510-fo7p98np 108 37 controlled control VBN cord-274510-fo7p98np 108 38 clinical clinical JJ cord-274510-fo7p98np 108 39 trials trial NNS cord-274510-fo7p98np 108 40 verifying verify VBG cord-274510-fo7p98np 108 41 these these DT cord-274510-fo7p98np 108 42 preliminary preliminary JJ cord-274510-fo7p98np 108 43 results result NNS cord-274510-fo7p98np 108 44 have have VBP cord-274510-fo7p98np 108 45 been be VBN cord-274510-fo7p98np 108 46 made make VBN cord-274510-fo7p98np 108 47 till till IN cord-274510-fo7p98np 108 48 now now RB cord-274510-fo7p98np 108 49 . . . cord-274510-fo7p98np 109 1 So so RB cord-274510-fo7p98np 109 2 , , , cord-274510-fo7p98np 109 3 there there EX cord-274510-fo7p98np 109 4 are be VBP cord-274510-fo7p98np 109 5 still still RB cord-274510-fo7p98np 109 6 unresolved unresolved JJ cord-274510-fo7p98np 109 7 controversies controversy NNS cord-274510-fo7p98np 109 8 about about IN cord-274510-fo7p98np 109 9 the the DT cord-274510-fo7p98np 109 10 possibility possibility NN cord-274510-fo7p98np 109 11 of of IN cord-274510-fo7p98np 109 12 an an DT cord-274510-fo7p98np 109 13 its -PRON- PRP$ cord-274510-fo7p98np 109 14 therapeutic therapeutic JJ cord-274510-fo7p98np 109 15 application application NN cord-274510-fo7p98np 109 16 . . . cord-274510-fo7p98np 110 1 To to IN cord-274510-fo7p98np 110 2 date date NN cord-274510-fo7p98np 110 3 , , , cord-274510-fo7p98np 110 4 no no DT cord-274510-fo7p98np 110 5 other other JJ cord-274510-fo7p98np 110 6 researcher researcher NN cord-274510-fo7p98np 110 7 has have VBZ cord-274510-fo7p98np 110 8 investigated investigate VBN cord-274510-fo7p98np 110 9 the the DT cord-274510-fo7p98np 110 10 possibility possibility NN cord-274510-fo7p98np 110 11 of of IN cord-274510-fo7p98np 110 12 a a DT cord-274510-fo7p98np 110 13 potential potential JJ cord-274510-fo7p98np 110 14 linkage linkage NN cord-274510-fo7p98np 110 15 between between IN cord-274510-fo7p98np 110 16 GcMAF GcMAF NNP cord-274510-fo7p98np 110 17 and and CC cord-274510-fo7p98np 110 18 COVID-19 COVID-19 NNP cord-274510-fo7p98np 110 19 . . . cord-274510-fo7p98np 111 1 However however RB cord-274510-fo7p98np 111 2 , , , cord-274510-fo7p98np 111 3 in in IN cord-274510-fo7p98np 111 4 view view NN cord-274510-fo7p98np 111 5 of of IN cord-274510-fo7p98np 111 6 the the DT cord-274510-fo7p98np 111 7 immunomodulatory immunomodulatory JJ cord-274510-fo7p98np 111 8 potential potential NN cord-274510-fo7p98np 111 9 and and CC cord-274510-fo7p98np 111 10 the the DT cord-274510-fo7p98np 111 11 high high JJ cord-274510-fo7p98np 111 12 safety safety NN cord-274510-fo7p98np 111 13 profile profile NN cord-274510-fo7p98np 111 14 of of IN cord-274510-fo7p98np 111 15 GcMAF GcMAF NNP cord-274510-fo7p98np 111 16 and and CC cord-274510-fo7p98np 111 17 because because IN cord-274510-fo7p98np 111 18 COVID-19 COVID-19 NNP cord-274510-fo7p98np 111 19 remains remain VBZ cord-274510-fo7p98np 111 20 a a DT cord-274510-fo7p98np 111 21 life life NN cord-274510-fo7p98np 111 22 - - HYPH cord-274510-fo7p98np 111 23 threatening threaten VBG cord-274510-fo7p98np 111 24 condition condition NN cord-274510-fo7p98np 111 25 in in IN cord-274510-fo7p98np 111 26 many many JJ cord-274510-fo7p98np 111 27 cases case NNS cord-274510-fo7p98np 111 28 , , , cord-274510-fo7p98np 111 29 despite despite IN cord-274510-fo7p98np 111 30 currently currently RB cord-274510-fo7p98np 111 31 recommended recommend VBN cord-274510-fo7p98np 111 32 therapies therapy NNS cord-274510-fo7p98np 111 33 , , , cord-274510-fo7p98np 111 34 we -PRON- PRP cord-274510-fo7p98np 111 35 think think VBP cord-274510-fo7p98np 111 36 it -PRON- PRP cord-274510-fo7p98np 111 37 is be VBZ cord-274510-fo7p98np 111 38 worth worth JJ cord-274510-fo7p98np 111 39 explorating explorate VBG cord-274510-fo7p98np 111 40 our -PRON- PRP$ cord-274510-fo7p98np 111 41 hypothesis hypothesis NN cord-274510-fo7p98np 111 42 further further RB cord-274510-fo7p98np 111 43 by by RB cord-274510-fo7p98np 111 44 : : : cord-274510-fo7p98np 112 1 In in IN cord-274510-fo7p98np 112 2 conclusion conclusion NN cord-274510-fo7p98np 112 3 , , , cord-274510-fo7p98np 112 4 even even RB cord-274510-fo7p98np 112 5 though though IN cord-274510-fo7p98np 112 6 our -PRON- PRP$ cord-274510-fo7p98np 112 7 hypothesis hypothesis NN cord-274510-fo7p98np 112 8 might may MD cord-274510-fo7p98np 112 9 be be VB cord-274510-fo7p98np 112 10 not not RB cord-274510-fo7p98np 112 11 fully fully RB cord-274510-fo7p98np 112 12 correct correct JJ cord-274510-fo7p98np 112 13 , , , cord-274510-fo7p98np 112 14 we -PRON- PRP cord-274510-fo7p98np 112 15 still still RB cord-274510-fo7p98np 112 16 wanted want VBD cord-274510-fo7p98np 112 17 to to TO cord-274510-fo7p98np 112 18 give give VB cord-274510-fo7p98np 112 19 our -PRON- PRP$ cord-274510-fo7p98np 112 20 own own JJ cord-274510-fo7p98np 112 21 contribution contribution NN cord-274510-fo7p98np 112 22 to to IN cord-274510-fo7p98np 112 23 the the DT cord-274510-fo7p98np 112 24 research research NN cord-274510-fo7p98np 112 25 on on IN cord-274510-fo7p98np 112 26 COVID-19 COVID-19 NNP cord-274510-fo7p98np 112 27 pandemic pandemic NN cord-274510-fo7p98np 112 28 which which WDT cord-274510-fo7p98np 112 29 had have VBD cord-274510-fo7p98np 112 30 the the DT cord-274510-fo7p98np 112 31 only only JJ cord-274510-fo7p98np 112 32 underserved underserved JJ cord-274510-fo7p98np 112 33 merit merit NN cord-274510-fo7p98np 112 34 to to TO cord-274510-fo7p98np 112 35 give give VB cord-274510-fo7p98np 112 36 all all DT cord-274510-fo7p98np 112 37 humans human NNS cord-274510-fo7p98np 112 38 across across IN cord-274510-fo7p98np 112 39 the the DT cord-274510-fo7p98np 112 40 world world NN cord-274510-fo7p98np 112 41 a a DT cord-274510-fo7p98np 112 42 common common JJ cord-274510-fo7p98np 112 43 goal goal NN cord-274510-fo7p98np 112 44 . . . cord-274510-fo7p98np 113 1 So so RB cord-274510-fo7p98np 113 2 , , , cord-274510-fo7p98np 113 3 as as IN cord-274510-fo7p98np 113 4 we -PRON- PRP cord-274510-fo7p98np 113 5 still still RB cord-274510-fo7p98np 113 6 see see VBP cord-274510-fo7p98np 113 7 life life NN cord-274510-fo7p98np 113 8 from from IN cord-274510-fo7p98np 113 9 a a DT cord-274510-fo7p98np 113 10 rosy rosy JJ cord-274510-fo7p98np 113 11 perspective perspective NN cord-274510-fo7p98np 113 12 from from IN cord-274510-fo7p98np 113 13 this this DT cord-274510-fo7p98np 113 14 small small JJ cord-274510-fo7p98np 113 15 Italian italian JJ cord-274510-fo7p98np 113 16 hospital hospital NN cord-274510-fo7p98np 113 17 facing face VBG cord-274510-fo7p98np 113 18 the the DT cord-274510-fo7p98np 113 19 sea sea NN cord-274510-fo7p98np 113 20 , , , cord-274510-fo7p98np 113 21 our -PRON- PRP$ cord-274510-fo7p98np 113 22 last last JJ cord-274510-fo7p98np 113 23 thought thought NN cord-274510-fo7p98np 113 24 and and CC cord-274510-fo7p98np 113 25 gratitude gratitude NN cord-274510-fo7p98np 113 26 are be VBP cord-274510-fo7p98np 113 27 for for IN cord-274510-fo7p98np 113 28 all all PDT cord-274510-fo7p98np 113 29 the the DT cord-274510-fo7p98np 113 30 researchers researcher NNS cord-274510-fo7p98np 113 31 and and CC cord-274510-fo7p98np 113 32 health health NN cord-274510-fo7p98np 113 33 care care NN cord-274510-fo7p98np 113 34 professionals professional NNS cord-274510-fo7p98np 113 35 which which WDT cord-274510-fo7p98np 113 36 are be VBP cord-274510-fo7p98np 113 37 committed commit VBN cord-274510-fo7p98np 113 38 to to IN cord-274510-fo7p98np 113 39 the the DT cord-274510-fo7p98np 113 40 forefront forefront NN cord-274510-fo7p98np 113 41 of of IN cord-274510-fo7p98np 113 42 the the DT cord-274510-fo7p98np 113 43 war war NN cord-274510-fo7p98np 113 44 against against IN cord-274510-fo7p98np 113 45 SARS SARS NNP cord-274510-fo7p98np 113 46 - - HYPH cord-274510-fo7p98np 113 47 CoV-2 CoV-2 NNP cord-274510-fo7p98np 113 48 . . . cord-274510-fo7p98np 114 1 World World NNP cord-274510-fo7p98np 114 2 Health Health NNP cord-274510-fo7p98np 114 3 Organization Organization NNP cord-274510-fo7p98np 114 4 Clinical clinical JJ cord-274510-fo7p98np 114 5 characteristics characteristic NNS cord-274510-fo7p98np 114 6 of of IN cord-274510-fo7p98np 114 7 coronavirus coronavirus NN cord-274510-fo7p98np 114 8 disease disease NN cord-274510-fo7p98np 114 9 2019 2019 CD cord-274510-fo7p98np 114 10 in in IN cord-274510-fo7p98np 114 11 China China NNP cord-274510-fo7p98np 114 12 Epidemiological epidemiological JJ cord-274510-fo7p98np 114 13 and and CC cord-274510-fo7p98np 114 14 clinical clinical JJ cord-274510-fo7p98np 114 15 characteristics characteristic NNS cord-274510-fo7p98np 114 16 of of IN cord-274510-fo7p98np 114 17 99 99 CD cord-274510-fo7p98np 114 18 cases case NNS cord-274510-fo7p98np 114 19 of of IN cord-274510-fo7p98np 114 20 2019 2019 CD cord-274510-fo7p98np 114 21 novel novel JJ cord-274510-fo7p98np 114 22 coronavirus coronavirus NN cord-274510-fo7p98np 114 23 pneumonia pneumonia NN cord-274510-fo7p98np 114 24 in in IN cord-274510-fo7p98np 114 25 Wuhan Wuhan NNP cord-274510-fo7p98np 114 26 , , , cord-274510-fo7p98np 114 27 China China NNP cord-274510-fo7p98np 114 28 : : : cord-274510-fo7p98np 114 29 a a DT cord-274510-fo7p98np 114 30 descriptive descriptive JJ cord-274510-fo7p98np 114 31 study study NN cord-274510-fo7p98np 114 32 Clinical clinical JJ cord-274510-fo7p98np 114 33 features feature NNS cord-274510-fo7p98np 114 34 of of IN cord-274510-fo7p98np 114 35 patients patient NNS cord-274510-fo7p98np 114 36 infected infect VBN cord-274510-fo7p98np 114 37 with with IN cord-274510-fo7p98np 114 38 2019 2019 CD cord-274510-fo7p98np 114 39 novel novel JJ cord-274510-fo7p98np 114 40 coronavirus coronavirus NN cord-274510-fo7p98np 114 41 in in IN cord-274510-fo7p98np 114 42 Wuhan Wuhan NNP cord-274510-fo7p98np 114 43 , , , cord-274510-fo7p98np 114 44 China China NNP cord-274510-fo7p98np 114 45 . . . cord-274510-fo7p98np 115 1 Lancet Lancet NNP cord-274510-fo7p98np 115 2 Coronavirus Coronavirus NNP cord-274510-fo7p98np 115 3 Disease Disease NNP cord-274510-fo7p98np 115 4 2019 2019 CD cord-274510-fo7p98np 115 5 ( ( -LRB- cord-274510-fo7p98np 115 6 COVID-19 COVID-19 NNP cord-274510-fo7p98np 115 7 ) ) -RRB- cord-274510-fo7p98np 115 8 : : : cord-274510-fo7p98np 116 1 A a DT cord-274510-fo7p98np 116 2 Clinical clinical JJ cord-274510-fo7p98np 116 3 Update update NN cord-274510-fo7p98np 116 4 Longitudinal longitudinal JJ cord-274510-fo7p98np 116 5 characteristics characteristic NNS cord-274510-fo7p98np 116 6 of of IN cord-274510-fo7p98np 116 7 lymphocyte lymphocyte NN cord-274510-fo7p98np 116 8 responses response NNS cord-274510-fo7p98np 116 9 and and CC cord-274510-fo7p98np 116 10 cytokine cytokine NN cord-274510-fo7p98np 116 11 profiles profile NNS cord-274510-fo7p98np 116 12 in in IN cord-274510-fo7p98np 116 13 the the DT cord-274510-fo7p98np 116 14 peripheral peripheral JJ cord-274510-fo7p98np 116 15 blood blood NN cord-274510-fo7p98np 116 16 of of IN cord-274510-fo7p98np 116 17 SARS SARS NNP cord-274510-fo7p98np 116 18 - - HYPH cord-274510-fo7p98np 116 19 CoV-2 CoV-2 NNP cord-274510-fo7p98np 116 20 infected infect VBD cord-274510-fo7p98np 116 21 patients patient NNS cord-274510-fo7p98np 116 22 SARS SARS NNP cord-274510-fo7p98np 116 23 - - HYPH cord-274510-fo7p98np 116 24 CoV-2 CoV-2 NNP cord-274510-fo7p98np 116 25 and and CC cord-274510-fo7p98np 116 26 viral viral JJ cord-274510-fo7p98np 116 27 sepsis sepsis NN cord-274510-fo7p98np 116 28 : : : cord-274510-fo7p98np 117 1 observations observation NNS cord-274510-fo7p98np 117 2 and and CC cord-274510-fo7p98np 117 3 hypotheses hypothesis NNS cord-274510-fo7p98np 117 4 Radiological radiological JJ cord-274510-fo7p98np 117 5 findings finding NNS cord-274510-fo7p98np 117 6 from from IN cord-274510-fo7p98np 117 7 81 81 CD cord-274510-fo7p98np 117 8 patients patient NNS cord-274510-fo7p98np 117 9 with with IN cord-274510-fo7p98np 117 10 COVID-19 covid-19 JJ cord-274510-fo7p98np 117 11 pneumonia pneumonia NN cord-274510-fo7p98np 117 12 in in IN cord-274510-fo7p98np 117 13 Wuhan Wuhan NNP cord-274510-fo7p98np 117 14 , , , cord-274510-fo7p98np 117 15 China China NNP cord-274510-fo7p98np 117 16 : : : cord-274510-fo7p98np 117 17 a a DT cord-274510-fo7p98np 117 18 descriptive descriptive JJ cord-274510-fo7p98np 117 19 study study NN cord-274510-fo7p98np 117 20 COVID-19 COVID-19 NNP cord-274510-fo7p98np 117 21 Autopsies Autopsies NNP cord-274510-fo7p98np 117 22 Pulmonary Pulmonary NNP cord-274510-fo7p98np 117 23 pathology pathology NN cord-274510-fo7p98np 117 24 of of IN cord-274510-fo7p98np 117 25 early early JJ cord-274510-fo7p98np 117 26 - - HYPH cord-274510-fo7p98np 117 27 phase phase NN cord-274510-fo7p98np 117 28 2019 2019 CD cord-274510-fo7p98np 117 29 novel novel NN cord-274510-fo7p98np 117 30 coronavirus coronavirus NN cord-274510-fo7p98np 117 31 ( ( -LRB- cord-274510-fo7p98np 117 32 COVID-19 COVID-19 NNP cord-274510-fo7p98np 117 33 ) ) -RRB- cord-274510-fo7p98np 117 34 pneumonia pneumonia NN cord-274510-fo7p98np 117 35 in in IN cord-274510-fo7p98np 117 36 two two CD cord-274510-fo7p98np 117 37 patients patient NNS cord-274510-fo7p98np 117 38 with with IN cord-274510-fo7p98np 117 39 lung lung NN cord-274510-fo7p98np 117 40 cancer cancer NN cord-274510-fo7p98np 117 41 : : : cord-274510-fo7p98np 117 42 special special JJ cord-274510-fo7p98np 117 43 report report NN cord-274510-fo7p98np 118 1 Pathological pathological JJ cord-274510-fo7p98np 118 2 findings finding NNS cord-274510-fo7p98np 118 3 of of IN cord-274510-fo7p98np 118 4 COVID-19 COVID-19 NNP cord-274510-fo7p98np 118 5 associated associate VBN cord-274510-fo7p98np 118 6 with with IN cord-274510-fo7p98np 118 7 acute acute JJ cord-274510-fo7p98np 118 8 respiratory respiratory JJ cord-274510-fo7p98np 118 9 distress distress NN cord-274510-fo7p98np 118 10 syndrome syndrome NN cord-274510-fo7p98np 118 11 Pathological pathological JJ cord-274510-fo7p98np 118 12 study study NN cord-274510-fo7p98np 118 13 of of IN cord-274510-fo7p98np 118 14 the the DT cord-274510-fo7p98np 118 15 2019 2019 CD cord-274510-fo7p98np 118 16 novel novel JJ cord-274510-fo7p98np 118 17 coronavirus coronavirus NN cord-274510-fo7p98np 118 18 disease disease NN cord-274510-fo7p98np 118 19 ( ( -LRB- cord-274510-fo7p98np 118 20 COVID-19 covid-19 VB cord-274510-fo7p98np 118 21 ) ) -RRB- cord-274510-fo7p98np 118 22 through through IN cord-274510-fo7p98np 118 23 post post JJ cord-274510-fo7p98np 118 24 - - JJ cord-274510-fo7p98np 118 25 mortem mortem JJ cord-274510-fo7p98np 118 26 core core NN cord-274510-fo7p98np 118 27 biopsies biopsy NNS cord-274510-fo7p98np 119 1 A a DT cord-274510-fo7p98np 119 2 tug tug NN cord-274510-fo7p98np 119 3 - - HYPH cord-274510-fo7p98np 119 4 of of IN cord-274510-fo7p98np 119 5 - - HYPH cord-274510-fo7p98np 119 6 war war NN cord-274510-fo7p98np 119 7 between between IN cord-274510-fo7p98np 119 8 severe severe JJ cord-274510-fo7p98np 119 9 acute acute JJ cord-274510-fo7p98np 119 10 respiratory respiratory JJ cord-274510-fo7p98np 119 11 syndrome syndrome NN cord-274510-fo7p98np 119 12 coronavirus coronavirus NN cord-274510-fo7p98np 119 13 2 2 CD cord-274510-fo7p98np 119 14 and and CC cord-274510-fo7p98np 119 15 host host NN cord-274510-fo7p98np 119 16 antiviral antiviral JJ cord-274510-fo7p98np 119 17 defence defence NN cord-274510-fo7p98np 119 18 : : : cord-274510-fo7p98np 119 19 lessons lesson NNS cord-274510-fo7p98np 119 20 from from IN cord-274510-fo7p98np 119 21 other other JJ cord-274510-fo7p98np 119 22 pathogenic pathogenic JJ cord-274510-fo7p98np 119 23 viruses virus NNS cord-274510-fo7p98np 119 24 . . . cord-274510-fo7p98np 120 1 Emerg Emerg NNP cord-274510-fo7p98np 120 2 Microbes microbe NNS cord-274510-fo7p98np 120 3 Infect infect VBP cord-274510-fo7p98np 120 4 Structural structural JJ cord-274510-fo7p98np 120 5 Modification modification NN cord-274510-fo7p98np 120 6 of of IN cord-274510-fo7p98np 120 7 Serum Serum NNP cord-274510-fo7p98np 120 8 Vitamin vitamin NN cord-274510-fo7p98np 120 9 D3-binding D3-binding NNP cord-274510-fo7p98np 120 10 Protein Protein NNP cord-274510-fo7p98np 120 11 and and CC cord-274510-fo7p98np 120 12 Immunosuppression Immunosuppression NNP cord-274510-fo7p98np 120 13 in in IN cord-274510-fo7p98np 120 14 AIDS AIDS NNP cord-274510-fo7p98np 120 15 Patients Patients NNP cord-274510-fo7p98np 120 16 Pathogenic pathogenic JJ cord-274510-fo7p98np 120 17 significance significance NN cord-274510-fo7p98np 120 18 of of IN cord-274510-fo7p98np 120 19 alpha alpha NN cord-274510-fo7p98np 120 20 - - HYPH cord-274510-fo7p98np 120 21 N n JJ cord-274510-fo7p98np 120 22 - - HYPH cord-274510-fo7p98np 120 23 acetylgalactosaminidase acetylgalactosaminidase JJ cord-274510-fo7p98np 120 24 activity activity NN cord-274510-fo7p98np 120 25 found find VBN cord-274510-fo7p98np 120 26 in in IN cord-274510-fo7p98np 120 27 the the DT cord-274510-fo7p98np 120 28 envelope envelope NN cord-274510-fo7p98np 120 29 glycoprotein glycoprotein NN cord-274510-fo7p98np 120 30 gp160 gp160 NNP cord-274510-fo7p98np 120 31 of of IN cord-274510-fo7p98np 120 32 human human JJ cord-274510-fo7p98np 120 33 immunodeficiency immunodeficiency NN cord-274510-fo7p98np 120 34 virus virus NN cord-274510-fo7p98np 120 35 Type type NN cord-274510-fo7p98np 120 36 1 1 CD cord-274510-fo7p98np 120 37 Turnover turnover NN cord-274510-fo7p98np 120 38 of of IN cord-274510-fo7p98np 120 39 the the DT cord-274510-fo7p98np 120 40 plasma plasma NN cord-274510-fo7p98np 120 41 binding bind VBG cord-274510-fo7p98np 120 42 protein protein NN cord-274510-fo7p98np 120 43 for for IN cord-274510-fo7p98np 120 44 vitamin vitamin NN cord-274510-fo7p98np 120 45 D d NN cord-274510-fo7p98np 120 46 and and CC cord-274510-fo7p98np 120 47 its -PRON- PRP$ cord-274510-fo7p98np 120 48 metabolites metabolite NNS cord-274510-fo7p98np 120 49 in in IN cord-274510-fo7p98np 120 50 normal normal JJ cord-274510-fo7p98np 120 51 human human JJ cord-274510-fo7p98np 120 52 subjects subject NNS cord-274510-fo7p98np 120 53 Vitamin Vitamin NNP cord-274510-fo7p98np 120 54 D3 D3 NNP cord-274510-fo7p98np 120 55 binding bind VBG cord-274510-fo7p98np 120 56 protein protein NN cord-274510-fo7p98np 120 57 ( ( -LRB- cord-274510-fo7p98np 120 58 group group NN cord-274510-fo7p98np 120 59 - - HYPH cord-274510-fo7p98np 120 60 specific specific JJ cord-274510-fo7p98np 120 61 component component NN cord-274510-fo7p98np 120 62 ) ) -RRB- cord-274510-fo7p98np 120 63 is be VBZ cord-274510-fo7p98np 120 64 a a DT cord-274510-fo7p98np 120 65 precursor precursor NN cord-274510-fo7p98np 120 66 for for IN cord-274510-fo7p98np 120 67 the the DT cord-274510-fo7p98np 120 68 macrophage macrophage NN cord-274510-fo7p98np 120 69 - - HYPH cord-274510-fo7p98np 120 70 activating activate VBG cord-274510-fo7p98np 120 71 signal signal NN cord-274510-fo7p98np 120 72 factor factor NN cord-274510-fo7p98np 120 73 from from IN cord-274510-fo7p98np 120 74 lysophosphatidylcholine lysophosphatidylcholine NNP cord-274510-fo7p98np 120 75 -treated -treate VBN cord-274510-fo7p98np 120 76 lymphocytes lymphocyte VBZ cord-274510-fo7p98np 120 77 Vitamin vitamin NN cord-274510-fo7p98np 120 78 D3-binding d3-binding NN cord-274510-fo7p98np 120 79 protein protein NN cord-274510-fo7p98np 120 80 as as IN cord-274510-fo7p98np 120 81 a a DT cord-274510-fo7p98np 120 82 precursor precursor NN cord-274510-fo7p98np 120 83 for for IN cord-274510-fo7p98np 120 84 macrophage macrophage NN cord-274510-fo7p98np 120 85 activating activate VBG cord-274510-fo7p98np 120 86 factor factor NN cord-274510-fo7p98np 120 87 in in IN cord-274510-fo7p98np 120 88 the the DT cord-274510-fo7p98np 120 89 inflammation inflammation NN cord-274510-fo7p98np 120 90 - - HYPH cord-274510-fo7p98np 120 91 primed prime VBN cord-274510-fo7p98np 120 92 macrophage macrophage NN cord-274510-fo7p98np 120 93 activation activation NN cord-274510-fo7p98np 120 94 cascade cascade NN cord-274510-fo7p98np 120 95 in in IN cord-274510-fo7p98np 120 96 rats rat NNS cord-274510-fo7p98np 120 97 Regulation regulation NN cord-274510-fo7p98np 120 98 of of IN cord-274510-fo7p98np 120 99 inflammation inflammation NN cord-274510-fo7p98np 120 100 - - HYPH cord-274510-fo7p98np 120 101 primed prime VBN cord-274510-fo7p98np 120 102 activation activation NN cord-274510-fo7p98np 120 103 of of IN cord-274510-fo7p98np 120 104 macrophages macrophage NNS cord-274510-fo7p98np 120 105 by by IN cord-274510-fo7p98np 120 106 two two CD cord-274510-fo7p98np 120 107 serum serum NN cord-274510-fo7p98np 120 108 factors factor NNS cord-274510-fo7p98np 120 109 , , , cord-274510-fo7p98np 120 110 vitamin vitamin NN cord-274510-fo7p98np 120 111 D3-binding d3-binding NN cord-274510-fo7p98np 120 112 protein protein NN cord-274510-fo7p98np 120 113 and and CC cord-274510-fo7p98np 120 114 albumin albumin NN cord-274510-fo7p98np 120 115 Pathogenic pathogenic JJ cord-274510-fo7p98np 120 116 significance significance NN cord-274510-fo7p98np 120 117 of of IN cord-274510-fo7p98np 120 118 alpha alpha NN cord-274510-fo7p98np 120 119 - - HYPH cord-274510-fo7p98np 120 120 N n JJ cord-274510-fo7p98np 120 121 - - HYPH cord-274510-fo7p98np 120 122 acetylgalactosaminidase acetylgalactosaminidase JJ cord-274510-fo7p98np 120 123 activity activity NN cord-274510-fo7p98np 120 124 found find VBN cord-274510-fo7p98np 120 125 in in IN cord-274510-fo7p98np 120 126 the the DT cord-274510-fo7p98np 120 127 hemagglutinin hemagglutinin NN cord-274510-fo7p98np 120 128 of of IN cord-274510-fo7p98np 120 129 influenza influenza NN cord-274510-fo7p98np 120 130 virus virus NN cord-274510-fo7p98np 120 131 . . . cord-274510-fo7p98np 121 1 Microbes microbe NNS cord-274510-fo7p98np 121 2 Infect infect VBP cord-274510-fo7p98np 122 1 Deglyco Deglyco NNS cord-274510-fo7p98np 122 2 - - HYPH cord-274510-fo7p98np 122 3 sylation sylation NN cord-274510-fo7p98np 122 4 of of IN cord-274510-fo7p98np 122 5 serum serum NN cord-274510-fo7p98np 122 6 vitamin vitamin NN cord-274510-fo7p98np 122 7 D3-binding d3-binding NN cord-274510-fo7p98np 122 8 protein protein NN cord-274510-fo7p98np 122 9 leads lead VBZ cord-274510-fo7p98np 122 10 to to IN cord-274510-fo7p98np 122 11 immunosuppression immunosuppression NN cord-274510-fo7p98np 122 12 in in IN cord-274510-fo7p98np 122 13 cancer cancer NN cord-274510-fo7p98np 122 14 patients patient NNS cord-274510-fo7p98np 123 1 Is be VBZ cord-274510-fo7p98np 124 1 α α NNP cord-274510-fo7p98np 124 2 - - HYPH cord-274510-fo7p98np 124 3 N N NNP cord-274510-fo7p98np 124 4 - - HYPH cord-274510-fo7p98np 124 5 acetylgalactosaminidase acetylgalactosaminidase NNP cord-274510-fo7p98np 125 1 the the DT cord-274510-fo7p98np 125 2 key key NN cord-274510-fo7p98np 125 3 to to IN cord-274510-fo7p98np 125 4 curing cure VBG cord-274510-fo7p98np 125 5 cancer cancer NN cord-274510-fo7p98np 125 6 ? ? . cord-274510-fo7p98np 126 1 A a DT cord-274510-fo7p98np 126 2 mini mini JJ cord-274510-fo7p98np 126 3 - - NN cord-274510-fo7p98np 126 4 review review NN cord-274510-fo7p98np 126 5 and and CC cord-274510-fo7p98np 126 6 hypothesis hypothesis NN cord-274510-fo7p98np 126 7 Promising promising JJ cord-274510-fo7p98np 126 8 role role NN cord-274510-fo7p98np 126 9 for for IN cord-274510-fo7p98np 126 10 Gc Gc NNP cord-274510-fo7p98np 126 11 - - HYPH cord-274510-fo7p98np 126 12 MAF MAF NNP cord-274510-fo7p98np 126 13 in in IN cord-274510-fo7p98np 126 14 cancer cancer NN cord-274510-fo7p98np 126 15 immunotherapy immunotherapy NN cord-274510-fo7p98np 126 16 : : : cord-274510-fo7p98np 126 17 from from IN cord-274510-fo7p98np 126 18 bench bench NN cord-274510-fo7p98np 126 19 to to IN cord-274510-fo7p98np 126 20 bedside bedside NN cord-274510-fo7p98np 126 21 Gc Gc NNP cord-274510-fo7p98np 126 22 protein protein NN cord-274510-fo7p98np 126 23 ( ( -LRB- cord-274510-fo7p98np 126 24 vitamin vitamin NN cord-274510-fo7p98np 126 25 D d NN cord-274510-fo7p98np 126 26 - - HYPH cord-274510-fo7p98np 126 27 binding bind VBG cord-274510-fo7p98np 126 28 protein protein NN cord-274510-fo7p98np 126 29 ) ) -RRB- cord-274510-fo7p98np 126 30 : : : cord-274510-fo7p98np 127 1 Gc Gc NNP cord-274510-fo7p98np 127 2 genotyping genotyping NN cord-274510-fo7p98np 127 3 and and CC cord-274510-fo7p98np 127 4 GcMAF GcMAF NNPS cord-274510-fo7p98np 128 1 precursor precursor NN cord-274510-fo7p98np 128 2 activity activity NN cord-274510-fo7p98np 128 3 Is be VBZ cord-274510-fo7p98np 128 4 chondroitin chondroitin NN cord-274510-fo7p98np 128 5 sulfate sulfate NN cord-274510-fo7p98np 128 6 responsible responsible JJ cord-274510-fo7p98np 128 7 for for IN cord-274510-fo7p98np 128 8 the the DT cord-274510-fo7p98np 128 9 biological biological JJ cord-274510-fo7p98np 128 10 effects effect NNS cord-274510-fo7p98np 128 11 attributed attribute VBN cord-274510-fo7p98np 128 12 to to IN cord-274510-fo7p98np 128 13 the the DT cord-274510-fo7p98np 128 14 GC GC NNP cord-274510-fo7p98np 128 15 protein protein NN cord-274510-fo7p98np 128 16 - - HYPH cord-274510-fo7p98np 128 17 derived derive VBN cord-274510-fo7p98np 128 18 Macrophage macrophage NN cord-274510-fo7p98np 128 19 Activating Activating NNP cord-274510-fo7p98np 128 20 Factor factor NN cord-274510-fo7p98np 128 21 ( ( -LRB- cord-274510-fo7p98np 128 22 GcMAF GcMAF NNP cord-274510-fo7p98np 128 23 ) ) -RRB- cord-274510-fo7p98np 128 24 ? ? . cord-274510-fo7p98np 129 1 Med Med NNP cord-274510-fo7p98np 129 2 Hypotheses Hypotheses NNP cord-274510-fo7p98np 129 3 Vitamin vitamin NN cord-274510-fo7p98np 129 4 D d NN cord-274510-fo7p98np 129 5 - - HYPH cord-274510-fo7p98np 129 6 binding bind VBG cord-274510-fo7p98np 129 7 protein protein NN cord-274510-fo7p98np 129 8 ( ( -LRB- cord-274510-fo7p98np 129 9 Gc Gc NNP cord-274510-fo7p98np 129 10 - - HYPH cord-274510-fo7p98np 129 11 globulin globulin NNP cord-274510-fo7p98np 129 12 ) ) -RRB- cord-274510-fo7p98np 129 13 binds bind VBZ cord-274510-fo7p98np 129 14 actin actin NN cord-274510-fo7p98np 129 15 Effects effect NNS cord-274510-fo7p98np 129 16 of of IN cord-274510-fo7p98np 129 17 vitamin vitamin NN cord-274510-fo7p98np 129 18 D(3)-binding d(3)-binding NN cord-274510-fo7p98np 129 19 protein protein NN cord-274510-fo7p98np 129 20 - - HYPH cord-274510-fo7p98np 129 21 derived derive VBN cord-274510-fo7p98np 129 22 macrophage macrophage NN cord-274510-fo7p98np 129 23 activating activate VBG cord-274510-fo7p98np 129 24 factor factor NN cord-274510-fo7p98np 129 25 ( ( -LRB- cord-274510-fo7p98np 129 26 GcMAF GcMAF NNP cord-274510-fo7p98np 129 27 ) ) -RRB- cord-274510-fo7p98np 130 1 on on IN cord-274510-fo7p98np 130 2 angiogenesis angiogenesis NN cord-274510-fo7p98np 131 1 Plasma plasma NN cord-274510-fo7p98np 131 2 vitamin vitamin NN cord-274510-fo7p98np 131 3 D d NN cord-274510-fo7p98np 131 4 - - HYPH cord-274510-fo7p98np 131 5 binding bind VBG cord-274510-fo7p98np 131 6 protein protein NN cord-274510-fo7p98np 131 7 ( ( -LRB- cord-274510-fo7p98np 131 8 Gc Gc NNP cord-274510-fo7p98np 131 9 - - HYPH cord-274510-fo7p98np 131 10 globulin globulin NNP cord-274510-fo7p98np 131 11 ) ) -RRB- cord-274510-fo7p98np 131 12 : : : cord-274510-fo7p98np 131 13 multiple multiple JJ cord-274510-fo7p98np 131 14 tasks task NNS cord-274510-fo7p98np 132 1 Do do VBP cord-274510-fo7p98np 132 2 Biomarkers Biomarkers NNPS cord-274510-fo7p98np 132 3 of of IN cord-274510-fo7p98np 132 4 Inflammation inflammation NN cord-274510-fo7p98np 132 5 , , , cord-274510-fo7p98np 132 6 Monocyte Monocyte NNP cord-274510-fo7p98np 132 7 Activation Activation NNP cord-274510-fo7p98np 132 8 , , , cord-274510-fo7p98np 132 9 and and CC cord-274510-fo7p98np 133 1 Altered altered JJ cord-274510-fo7p98np 133 2 Coagulation coagulation NN cord-274510-fo7p98np 133 3 Explain explain VBP cord-274510-fo7p98np 133 4 Excess excess NN cord-274510-fo7p98np 133 5 Mortality mortality NN cord-274510-fo7p98np 133 6 Between between IN cord-274510-fo7p98np 133 7 HIV HIV NNP cord-274510-fo7p98np 133 8 Infected Infected NNP cord-274510-fo7p98np 133 9 and and CC cord-274510-fo7p98np 133 10 Uninfected uninfected JJ cord-274510-fo7p98np 133 11 People People NNS cord-274510-fo7p98np 133 12 ? ? . cord-274510-fo7p98np 134 1 Mitogen Mitogen NNP cord-274510-fo7p98np 134 2 - - HYPH cord-274510-fo7p98np 134 3 activated activate VBN cord-274510-fo7p98np 134 4 protein protein NN cord-274510-fo7p98np 134 5 kinase kinase NN cord-274510-fo7p98np 134 6 pathway pathway NN cord-274510-fo7p98np 134 7 mediates mediate VBZ cord-274510-fo7p98np 134 8 DBP DBP NNP cord-274510-fo7p98np 134 9 - - HYPH cord-274510-fo7p98np 134 10 maf maf NN cord-274510-fo7p98np 134 11 - - HYPH cord-274510-fo7p98np 134 12 induced induce VBN cord-274510-fo7p98np 134 13 apoptosis apoptosis NN cord-274510-fo7p98np 134 14 in in IN cord-274510-fo7p98np 134 15 RAW raw JJ cord-274510-fo7p98np 134 16 264.7 264.7 CD cord-274510-fo7p98np 134 17 macrophages macrophage NNS cord-274510-fo7p98np 135 1 Oleic oleic NN cord-274510-fo7p98np 135 2 Acid acid NN cord-274510-fo7p98np 135 3 , , , cord-274510-fo7p98np 135 4 deglycosylated deglycosylated JJ cord-274510-fo7p98np 135 5 vitamin vitamin NN cord-274510-fo7p98np 135 6 D d NN cord-274510-fo7p98np 135 7 - - HYPH cord-274510-fo7p98np 135 8 binding bind VBG cord-274510-fo7p98np 135 9 protein protein NN cord-274510-fo7p98np 135 10 , , , cord-274510-fo7p98np 135 11 nitric nitric JJ cord-274510-fo7p98np 135 12 oxide oxide NN cord-274510-fo7p98np 135 13 : : : cord-274510-fo7p98np 135 14 a a DT cord-274510-fo7p98np 135 15 molecular molecular JJ cord-274510-fo7p98np 135 16 triad triad NN cord-274510-fo7p98np 135 17 made make VBD cord-274510-fo7p98np 135 18 lethal lethal JJ cord-274510-fo7p98np 135 19 to to IN cord-274510-fo7p98np 135 20 cancer cancer NN cord-274510-fo7p98np 135 21 Extracellular Extracellular NNP cord-274510-fo7p98np 135 22 superoxide superoxide NN cord-274510-fo7p98np 135 23 dismutase dismutase NN cord-274510-fo7p98np 135 24 Plasma Plasma NNP cord-274510-fo7p98np 135 25 concentration concentration NN cord-274510-fo7p98np 135 26 of of IN cord-274510-fo7p98np 135 27 Gc Gc NNP cord-274510-fo7p98np 135 28 - - HYPH cord-274510-fo7p98np 135 29 globulin globulin NNP cord-274510-fo7p98np 135 30 is be VBZ cord-274510-fo7p98np 135 31 associated associate VBN cord-274510-fo7p98np 135 32 with with IN cord-274510-fo7p98np 135 33 organ organ NN cord-274510-fo7p98np 135 34 dysfunction dysfunction NN cord-274510-fo7p98np 135 35 and and CC cord-274510-fo7p98np 135 36 sepsis sepsis NN cord-274510-fo7p98np 135 37 after after IN cord-274510-fo7p98np 135 38 injury injury NN cord-274510-fo7p98np 136 1 The the DT cord-274510-fo7p98np 136 2 extracellular extracellular JJ cord-274510-fo7p98np 136 3 actin actin NN cord-274510-fo7p98np 136 4 - - HYPH cord-274510-fo7p98np 136 5 scavenger scavenger NN cord-274510-fo7p98np 136 6 system system NN cord-274510-fo7p98np 136 7 and and CC cord-274510-fo7p98np 136 8 actin actin NN cord-274510-fo7p98np 136 9 toxicity toxicity NN cord-274510-fo7p98np 136 10 Vitamin vitamin NN cord-274510-fo7p98np 136 11 D d NN cord-274510-fo7p98np 136 12 - - HYPH cord-274510-fo7p98np 136 13 binding bind VBG cord-274510-fo7p98np 136 14 protein protein NN cord-274510-fo7p98np 136 15 ( ( -LRB- cord-274510-fo7p98np 136 16 Gc Gc NNP cord-274510-fo7p98np 136 17 - - HYPH cord-274510-fo7p98np 136 18 globulin globulin NNP cord-274510-fo7p98np 136 19 ) ) -RRB- cord-274510-fo7p98np 136 20 binds bind VBZ cord-274510-fo7p98np 136 21 actin actin NN cord-274510-fo7p98np 136 22 Coordinated coordinated JJ cord-274510-fo7p98np 136 23 inhibition inhibition NN cord-274510-fo7p98np 136 24 of of IN cord-274510-fo7p98np 136 25 actin actin NN cord-274510-fo7p98np 136 26 - - HYPH cord-274510-fo7p98np 136 27 induced induce VBN cord-274510-fo7p98np 136 28 platelet platelet NN cord-274510-fo7p98np 136 29 aggregation aggregation NN cord-274510-fo7p98np 136 30 by by IN cord-274510-fo7p98np 136 31 plasma plasma NN cord-274510-fo7p98np 136 32 gelsolin gelsolin NN cord-274510-fo7p98np 136 33 and and CC cord-274510-fo7p98np 136 34 vitamin vitamin NN cord-274510-fo7p98np 136 35 D d NN cord-274510-fo7p98np 136 36 - - HYPH cord-274510-fo7p98np 136 37 binding bind VBG cord-274510-fo7p98np 136 38 protein protein NN cord-274510-fo7p98np 136 39 Hematological Hematological NNP cord-274510-fo7p98np 136 40 findings finding NNS cord-274510-fo7p98np 136 41 and and CC cord-274510-fo7p98np 136 42 complications complication NNS cord-274510-fo7p98np 136 43 of of IN cord-274510-fo7p98np 136 44 COVID-19 covid-19 JJ cord-274510-fo7p98np 136 45 Abnormal abnormal JJ cord-274510-fo7p98np 136 46 coagulation coagulation NN cord-274510-fo7p98np 136 47 parameters parameter NNS cord-274510-fo7p98np 136 48 are be VBP cord-274510-fo7p98np 136 49 associated associate VBN cord-274510-fo7p98np 136 50 with with IN cord-274510-fo7p98np 136 51 poor poor JJ cord-274510-fo7p98np 136 52 prognosis prognosis NN cord-274510-fo7p98np 136 53 in in IN cord-274510-fo7p98np 136 54 patients patient NNS cord-274510-fo7p98np 136 55 with with IN cord-274510-fo7p98np 136 56 novel novel JJ cord-274510-fo7p98np 136 57 coronavirus coronavirus NN cord-274510-fo7p98np 136 58 pneumonia pneumonia NN cord-274510-fo7p98np 136 59 Circulating circulate VBG cord-274510-fo7p98np 136 60 complexes complex NNS cord-274510-fo7p98np 136 61 of of IN cord-274510-fo7p98np 136 62 the the DT cord-274510-fo7p98np 136 63 vitamin vitamin NN cord-274510-fo7p98np 136 64 D d NN cord-274510-fo7p98np 136 65 binding bind VBG cord-274510-fo7p98np 136 66 protein protein NN cord-274510-fo7p98np 136 67 with with IN cord-274510-fo7p98np 136 68 G g NN cord-274510-fo7p98np 136 69 - - HYPH cord-274510-fo7p98np 136 70 actin actin NN cord-274510-fo7p98np 136 71 induce induce VB cord-274510-fo7p98np 136 72 lung lung NN cord-274510-fo7p98np 136 73 inflammation inflammation NN cord-274510-fo7p98np 136 74 by by IN cord-274510-fo7p98np 136 75 targeting target VBG cord-274510-fo7p98np 136 76 endothelial endothelial JJ cord-274510-fo7p98np 136 77 cells cell NNS cord-274510-fo7p98np 136 78 Effect effect NN cord-274510-fo7p98np 136 79 of of IN cord-274510-fo7p98np 136 80 paricalcitol paricalcitol NNP cord-274510-fo7p98np 136 81 and and CC cord-274510-fo7p98np 136 82 GcMAF GcMAF NNP cord-274510-fo7p98np 137 1 on on IN cord-274510-fo7p98np 137 2 angiogenesis angiogenesis NN cord-274510-fo7p98np 137 3 and and CC cord-274510-fo7p98np 137 4 human human JJ cord-274510-fo7p98np 137 5 peripheral peripheral JJ cord-274510-fo7p98np 137 6 blood blood NN cord-274510-fo7p98np 137 7 mononuclear mononuclear JJ cord-274510-fo7p98np 137 8 cell cell NN cord-274510-fo7p98np 137 9 proliferation proliferation NN cord-274510-fo7p98np 137 10 and and CC cord-274510-fo7p98np 137 11 signaling signal VBG cord-274510-fo7p98np 137 12 Can Can MD cord-274510-fo7p98np 137 13 angiogenesis angiogenesis NN cord-274510-fo7p98np 137 14 be be VB cord-274510-fo7p98np 137 15 exploited exploit VBN cord-274510-fo7p98np 137 16 to to TO cord-274510-fo7p98np 137 17 improve improve VB cord-274510-fo7p98np 137 18 stroke stroke NN cord-274510-fo7p98np 137 19 outcome outcome NN cord-274510-fo7p98np 137 20 ? ? . cord-274510-fo7p98np 138 1 Mechanisms mechanism NNS cord-274510-fo7p98np 138 2 and and CC cord-274510-fo7p98np 138 3 therapeutic therapeutic JJ cord-274510-fo7p98np 138 4 potential potential JJ cord-274510-fo7p98np 138 5 Vascular vascular JJ cord-274510-fo7p98np 138 6 endothelial endothelial JJ cord-274510-fo7p98np 138 7 growth growth NN cord-274510-fo7p98np 138 8 factor factor NN cord-274510-fo7p98np 138 9 in in IN cord-274510-fo7p98np 138 10 acute acute JJ cord-274510-fo7p98np 138 11 lung lung NN cord-274510-fo7p98np 138 12 injury injury NN cord-274510-fo7p98np 138 13 and and CC cord-274510-fo7p98np 138 14 acute acute JJ cord-274510-fo7p98np 138 15 respiratory respiratory JJ cord-274510-fo7p98np 138 16 distress distress NN cord-274510-fo7p98np 138 17 syndrome syndrome NN cord-274510-fo7p98np 139 1 Sex sex NN cord-274510-fo7p98np 139 2 and and CC cord-274510-fo7p98np 139 3 Gender Gender NNP cord-274510-fo7p98np 139 4 Disparities Disparities NNPS cord-274510-fo7p98np 139 5 in in IN cord-274510-fo7p98np 139 6 the the DT cord-274510-fo7p98np 139 7 COVID-19 COVID-19 NNP cord-274510-fo7p98np 139 8 Pandemic Pandemic NNP cord-274510-fo7p98np 139 9 Vitamin vitamin NN cord-274510-fo7p98np 139 10 D D NNP cord-274510-fo7p98np 139 11 binding bind VBG cord-274510-fo7p98np 139 12 protein protein NN cord-274510-fo7p98np 139 13 gene gene NN cord-274510-fo7p98np 139 14 polymorphisms polymorphism NNS cord-274510-fo7p98np 139 15 and and CC cord-274510-fo7p98np 139 16 chronic chronic JJ cord-274510-fo7p98np 139 17 obstructive obstructive JJ cord-274510-fo7p98np 139 18 pulmonary pulmonary JJ cord-274510-fo7p98np 139 19 disease disease NN cord-274510-fo7p98np 139 20 : : : cord-274510-fo7p98np 139 21 a a DT cord-274510-fo7p98np 139 22 meta meta JJ cord-274510-fo7p98np 139 23 - - HYPH cord-274510-fo7p98np 139 24 analysis analysis NN cord-274510-fo7p98np 139 25 Investigation Investigation NNP cord-274510-fo7p98np 139 26 of of IN cord-274510-fo7p98np 139 27 Vitamin Vitamin NNP cord-274510-fo7p98np 139 28 D D NNP cord-274510-fo7p98np 139 29 - - HYPH cord-274510-fo7p98np 139 30 Binding Binding NNP cord-274510-fo7p98np 139 31 Protein Protein NNP cord-274510-fo7p98np 139 32 Polymorphism Polymorphism NNP cord-274510-fo7p98np 139 33 Impact Impact NNP cord-274510-fo7p98np 139 34 on on IN cord-274510-fo7p98np 139 35 Coronary Coronary NNP cord-274510-fo7p98np 139 36 Artery Artery NNP cord-274510-fo7p98np 139 37 Disease Disease NNP cord-274510-fo7p98np 139 38 and and CC cord-274510-fo7p98np 139 39 Relationship Relationship NNP cord-274510-fo7p98np 139 40 with with IN cord-274510-fo7p98np 139 41 Longevity Longevity NNP cord-274510-fo7p98np 139 42 : : : cord-274510-fo7p98np 140 1 Own own JJ cord-274510-fo7p98np 140 2 Data Data NNP cord-274510-fo7p98np 140 3 and and CC cord-274510-fo7p98np 140 4 a a DT cord-274510-fo7p98np 140 5 Review Review NNP cord-274510-fo7p98np 140 6 Vitamin vitamin NN cord-274510-fo7p98np 140 7 D d NN cord-274510-fo7p98np 140 8 physiology physiology NN cord-274510-fo7p98np 140 9 Changes change NNS cord-274510-fo7p98np 140 10 with with IN cord-274510-fo7p98np 140 11 malnutrition malnutrition NN cord-274510-fo7p98np 140 12 in in IN cord-274510-fo7p98np 140 13 the the DT cord-274510-fo7p98np 140 14 concentration concentration NN cord-274510-fo7p98np 140 15 of of IN cord-274510-fo7p98np 140 16 plasma plasma NN cord-274510-fo7p98np 140 17 vitamin vitamin NN cord-274510-fo7p98np 140 18 D d NN cord-274510-fo7p98np 140 19 binding bind VBG cord-274510-fo7p98np 140 20 protein protein NN cord-274510-fo7p98np 140 21 in in IN cord-274510-fo7p98np 140 22 growing grow VBG cord-274510-fo7p98np 140 23 rats rat NNS cord-274510-fo7p98np 140 24 Evidence evidence NN cord-274510-fo7p98np 140 25 that that IN cord-274510-fo7p98np 140 26 Vitamin vitamin NN cord-274510-fo7p98np 140 27 D d NN cord-274510-fo7p98np 140 28 Supplementation supplementation NN cord-274510-fo7p98np 140 29 Could Could MD cord-274510-fo7p98np 140 30 Reduce reduce VB cord-274510-fo7p98np 140 31 Risk risk NN cord-274510-fo7p98np 140 32 of of IN cord-274510-fo7p98np 140 33 Influenza Influenza NNP cord-274510-fo7p98np 140 34 and and CC cord-274510-fo7p98np 140 35 COVID-19 COVID-19 NNP cord-274510-fo7p98np 140 36 Infections Infections NNPS cord-274510-fo7p98np 140 37 and and CC cord-274510-fo7p98np 140 38 Deaths Deaths NNP cord-274510-fo7p98np 140 39 Sex sex NN cord-274510-fo7p98np 140 40 - - HYPH cord-274510-fo7p98np 140 41 Specific specific JJ cord-274510-fo7p98np 140 42 SARS SARS NNP cord-274510-fo7p98np 140 43 - - HYPH cord-274510-fo7p98np 140 44 CoV-2 CoV-2 NNP cord-274510-fo7p98np 140 45 Mortality mortality NN cord-274510-fo7p98np 140 46 : : : cord-274510-fo7p98np 141 1 Among among IN cord-274510-fo7p98np 141 2 Hormone hormone NN cord-274510-fo7p98np 141 3 - - HYPH cord-274510-fo7p98np 141 4 Modulated Modulated NNP cord-274510-fo7p98np 141 5 ACE2 ACE2 NNP cord-274510-fo7p98np 141 6 Expression expression NN cord-274510-fo7p98np 141 7 , , , cord-274510-fo7p98np 141 8 Risk risk NN cord-274510-fo7p98np 141 9 of of IN cord-274510-fo7p98np 141 10 Venous Venous NNP cord-274510-fo7p98np 141 11 Thromboembolism Thromboembolism NNP cord-274510-fo7p98np 141 12 and and CC cord-274510-fo7p98np 141 13 Hypovitaminosis Hypovitaminosis NNP cord-274510-fo7p98np 141 14 D D NNP cord-274510-fo7p98np 141 15 Early early JJ cord-274510-fo7p98np 141 16 nutritional nutritional JJ cord-274510-fo7p98np 141 17 supplementation supplementation NN cord-274510-fo7p98np 141 18 in in IN cord-274510-fo7p98np 141 19 noncritically noncritically RB cord-274510-fo7p98np 141 20 ill ill JJ cord-274510-fo7p98np 141 21 patients patient NNS cord-274510-fo7p98np 141 22 hospitalized hospitalize VBN cord-274510-fo7p98np 141 23 for for IN cord-274510-fo7p98np 141 24 the the DT cord-274510-fo7p98np 141 25 2019 2019 CD cord-274510-fo7p98np 141 26 novel novel JJ cord-274510-fo7p98np 141 27 coronavirus coronavirus NN cord-274510-fo7p98np 141 28 disease disease NN cord-274510-fo7p98np 141 29 ( ( -LRB- cord-274510-fo7p98np 141 30 COVID-19 COVID-19 NNP cord-274510-fo7p98np 141 31 ) ) -RRB- cord-274510-fo7p98np 141 32 : : : cord-274510-fo7p98np 142 1 Rationale rationale NN cord-274510-fo7p98np 142 2 and and CC cord-274510-fo7p98np 142 3 feasibility feasibility NN cord-274510-fo7p98np 142 4 of of IN cord-274510-fo7p98np 142 5 a a DT cord-274510-fo7p98np 142 6 shared share VBN cord-274510-fo7p98np 142 7 pragmatic pragmatic JJ cord-274510-fo7p98np 142 8 protocol protocol NN cord-274510-fo7p98np 142 9 Affinity Affinity NNP cord-274510-fo7p98np 142 10 purification purification NN cord-274510-fo7p98np 142 11 of of IN cord-274510-fo7p98np 142 12 human human JJ cord-274510-fo7p98np 142 13 plasma plasma NN cord-274510-fo7p98np 142 14 vitamin vitamin NN cord-274510-fo7p98np 142 15 D d NN cord-274510-fo7p98np 142 16 - - HYPH cord-274510-fo7p98np 142 17 binding bind VBG cord-274510-fo7p98np 142 18 protein protein NN cord-274510-fo7p98np 142 19 GcMAF GcMAF NNPS cord-274510-fo7p98np 142 20 : : : cord-274510-fo7p98np 143 1 our -PRON- PRP$ cord-274510-fo7p98np 143 2 next next JJ cord-274510-fo7p98np 143 3 - - HYPH cord-274510-fo7p98np 143 4 generation generation NN cord-274510-fo7p98np 143 5 immunotherapy immunotherapy NN cord-274510-fo7p98np 143 6 Degalactosylated Degalactosylated NNP cord-274510-fo7p98np 143 7 / / SYM cord-274510-fo7p98np 143 8 desialylated desialylate VBN cord-274510-fo7p98np 143 9 bovine bovine JJ cord-274510-fo7p98np 143 10 colostrum colostrum NN cord-274510-fo7p98np 143 11 induces induce VBZ cord-274510-fo7p98np 143 12 macrophage macrophage NN cord-274510-fo7p98np 143 13 phagocytic phagocytic JJ cord-274510-fo7p98np 143 14 activity activity NN cord-274510-fo7p98np 143 15 independently independently RB cord-274510-fo7p98np 143 16 of of IN cord-274510-fo7p98np 143 17 inflammatory inflammatory JJ cord-274510-fo7p98np 143 18 cytokine cytokine NN cord-274510-fo7p98np 143 19 production production NN cord-274510-fo7p98np 143 20 Oral oral JJ cord-274510-fo7p98np 143 21 colostrum colostrum NN cord-274510-fo7p98np 143 22 macrophage macrophage NN cord-274510-fo7p98np 143 23 - - HYPH cord-274510-fo7p98np 143 24 activating activate VBG cord-274510-fo7p98np 143 25 factor factor NN cord-274510-fo7p98np 143 26 for for IN cord-274510-fo7p98np 143 27 serious serious JJ cord-274510-fo7p98np 143 28 infection infection NN cord-274510-fo7p98np 143 29 and and CC cord-274510-fo7p98np 143 30 chronic chronic JJ cord-274510-fo7p98np 143 31 fatigue fatigue NN cord-274510-fo7p98np 143 32 syndrome syndrome NN cord-274510-fo7p98np 143 33 : : : cord-274510-fo7p98np 143 34 three three CD cord-274510-fo7p98np 143 35 case case NN cord-274510-fo7p98np 143 36 reports report VBZ cord-274510-fo7p98np 143 37 Immunotherapy Immunotherapy NNP cord-274510-fo7p98np 143 38 of of IN cord-274510-fo7p98np 143 39 HIV HIV NNP cord-274510-fo7p98np 143 40 - - HYPH cord-274510-fo7p98np 143 41 infected infect VBN cord-274510-fo7p98np 143 42 patients patient NNS cord-274510-fo7p98np 143 43 with with IN cord-274510-fo7p98np 143 44 Gc Gc NNP cord-274510-fo7p98np 143 45 proteinderived proteinderived NNP cord-274510-fo7p98np 143 46 macrophage macrophage NN cord-274510-fo7p98np 143 47 activating activate VBG cord-274510-fo7p98np 143 48 factor factor NN cord-274510-fo7p98np 143 49 ( ( -LRB- cord-274510-fo7p98np 143 50 GcMAF GcMAF NNP cord-274510-fo7p98np 143 51 ) ) -RRB- cord-274510-fo7p98np 143 52 Immunotherapy immunotherapy NN cord-274510-fo7p98np 143 53 for for IN cord-274510-fo7p98np 143 54 prostate prostate NN cord-274510-fo7p98np 143 55 cancer cancer NN cord-274510-fo7p98np 143 56 with with IN cord-274510-fo7p98np 143 57 Gc Gc NNP cord-274510-fo7p98np 143 58 protein protein NN cord-274510-fo7p98np 143 59 - - HYPH cord-274510-fo7p98np 143 60 derived derive VBN cord-274510-fo7p98np 143 61 macrophage macrophage NN cord-274510-fo7p98np 143 62 - - HYPH cord-274510-fo7p98np 143 63 activating activate VBG cord-274510-fo7p98np 143 64 factor factor NN cord-274510-fo7p98np 143 65 Therapeutic therapeutic JJ cord-274510-fo7p98np 143 66 effects effect NNS cord-274510-fo7p98np 143 67 of of IN cord-274510-fo7p98np 143 68 highly highly RB cord-274510-fo7p98np 143 69 purified purify VBN cord-274510-fo7p98np 143 70 de de NN cord-274510-fo7p98np 143 71 - - JJ cord-274510-fo7p98np 143 72 glycosylated glycosylated JJ cord-274510-fo7p98np 143 73 GcMAF GcMAF NNS cord-274510-fo7p98np 144 1 in in IN cord-274510-fo7p98np 144 2 the the DT cord-274510-fo7p98np 144 3 immunotherapy immunotherapy NN cord-274510-fo7p98np 144 4 of of IN cord-274510-fo7p98np 144 5 patients patient NNS cord-274510-fo7p98np 144 6 with with IN cord-274510-fo7p98np 144 7 chronic chronic JJ cord-274510-fo7p98np 144 8 diseases disease NNS cord-274510-fo7p98np 144 9 Clinical clinical JJ cord-274510-fo7p98np 144 10 experience experience NN cord-274510-fo7p98np 144 11 of of IN cord-274510-fo7p98np 144 12 integrative integrative JJ cord-274510-fo7p98np 144 13 cancer cancer NN cord-274510-fo7p98np 144 14 immunotherapy immunotherapy NN cord-274510-fo7p98np 144 15 with with IN cord-274510-fo7p98np 144 16 GcMAF GcMAF NNP cord-274510-fo7p98np 144 17 Case Case NNP cord-274510-fo7p98np 144 18 report report NN cord-274510-fo7p98np 144 19 : : : cord-274510-fo7p98np 144 20 A a DT cord-274510-fo7p98np 144 21 breast breast NN cord-274510-fo7p98np 144 22 cancer cancer NN cord-274510-fo7p98np 144 23 patient patient NN cord-274510-fo7p98np 144 24 treated treat VBN cord-274510-fo7p98np 144 25 with with IN cord-274510-fo7p98np 144 26 GcMAF GcMAF NNP cord-274510-fo7p98np 144 27 , , , cord-274510-fo7p98np 144 28 sonodynamic sonodynamic JJ cord-274510-fo7p98np 144 29 therapy therapy NN cord-274510-fo7p98np 144 30 and and CC cord-274510-fo7p98np 144 31 hormone hormone NN cord-274510-fo7p98np 144 32 therapy therapy NN cord-274510-fo7p98np 145 1 The the DT cord-274510-fo7p98np 145 2 use use NN cord-274510-fo7p98np 145 3 of of IN cord-274510-fo7p98np 145 4 Gc Gc NNP cord-274510-fo7p98np 145 5 protein protein NN cord-274510-fo7p98np 145 6 - - HYPH cord-274510-fo7p98np 145 7 derived derive VBN cord-274510-fo7p98np 145 8 macrophage macrophage NN cord-274510-fo7p98np 145 9 activating activate VBG cord-274510-fo7p98np 145 10 factor factor NN cord-274510-fo7p98np 145 11 for for IN cord-274510-fo7p98np 145 12 management management NN cord-274510-fo7p98np 145 13 of of IN cord-274510-fo7p98np 145 14 thyroid thyroid JJ cord-274510-fo7p98np 145 15 cancer cancer NN cord-274510-fo7p98np 145 16 Defective defective JJ cord-274510-fo7p98np 145 17 lymphocyte lymphocyte NN cord-274510-fo7p98np 145 18 glycosidases glycosidase NNS cord-274510-fo7p98np 145 19 in in IN cord-274510-fo7p98np 145 20 the the DT cord-274510-fo7p98np 145 21 macrophage macrophage NN cord-274510-fo7p98np 145 22 activation activation NN cord-274510-fo7p98np 145 23 cascade cascade NN cord-274510-fo7p98np 145 24 of of IN cord-274510-fo7p98np 145 25 juvenile juvenile JJ cord-274510-fo7p98np 145 26 osteopetrosis osteopetrosis NN cord-274510-fo7p98np 145 27 Deglycosylation Deglycosylation NNP cord-274510-fo7p98np 145 28 of of IN cord-274510-fo7p98np 145 29 serum serum NN cord-274510-fo7p98np 145 30 vitamin vitamin NN cord-274510-fo7p98np 145 31 D3-binding d3-binding NN cord-274510-fo7p98np 145 32 protein protein NN cord-274510-fo7p98np 145 33 by by IN cord-274510-fo7p98np 145 34 alpha alpha NN cord-274510-fo7p98np 145 35 - - HYPH cord-274510-fo7p98np 145 36 N N NNP cord-274510-fo7p98np 145 37 - - HYPH cord-274510-fo7p98np 145 38 acetylgalactosaminidase acetylgalactosaminidase NN cord-274510-fo7p98np 145 39 detected detect VBD cord-274510-fo7p98np 145 40 in in IN cord-274510-fo7p98np 145 41 the the DT cord-274510-fo7p98np 145 42 plasma plasma NN cord-274510-fo7p98np 145 43 of of IN cord-274510-fo7p98np 145 44 patients patient NNS cord-274510-fo7p98np 145 45 with with IN cord-274510-fo7p98np 145 46 systemic systemic JJ cord-274510-fo7p98np 145 47 lupus lupus NN cord-274510-fo7p98np 145 48 erythematosus erythematosus NN cord-274510-fo7p98np 145 49 Case Case NNP cord-274510-fo7p98np 145 50 report report NN cord-274510-fo7p98np 145 51 : : : cord-274510-fo7p98np 145 52 GcMAF gcmaf CD cord-274510-fo7p98np 145 53 treatment treatment NN cord-274510-fo7p98np 145 54 in in IN cord-274510-fo7p98np 145 55 a a DT cord-274510-fo7p98np 145 56 patient patient NN cord-274510-fo7p98np 145 57 with with IN cord-274510-fo7p98np 145 58 multiple multiple JJ cord-274510-fo7p98np 145 59 sclerosis sclerosis NN cord-274510-fo7p98np 145 60 Initial initial JJ cord-274510-fo7p98np 145 61 observations observation NNS cord-274510-fo7p98np 145 62 of of IN cord-274510-fo7p98np 145 63 elevated elevated JJ cord-274510-fo7p98np 145 64 alpha alpha NN cord-274510-fo7p98np 145 65 - - HYPH cord-274510-fo7p98np 145 66 Nacetylgalactosaminidase nacetylgalactosaminidase NN cord-274510-fo7p98np 145 67 activity activity NN cord-274510-fo7p98np 145 68 associated associate VBN cord-274510-fo7p98np 145 69 with with IN cord-274510-fo7p98np 145 70 autism autism NN cord-274510-fo7p98np 145 71 and and CC cord-274510-fo7p98np 145 72 observed observe VBD cord-274510-fo7p98np 145 73 reductions reduction NNS cord-274510-fo7p98np 145 74 from from IN cord-274510-fo7p98np 145 75 Gc Gc NNP cord-274510-fo7p98np 145 76 protein protein NN cord-274510-fo7p98np 145 77 -- -- : cord-274510-fo7p98np 145 78 macrophage macrophage NN cord-274510-fo7p98np 145 79 activating activate VBG cord-274510-fo7p98np 145 80 factor factor NN cord-274510-fo7p98np 145 81 injections injection NNS cord-274510-fo7p98np 145 82 Current current JJ cord-274510-fo7p98np 145 83 pharmacological pharmacological JJ cord-274510-fo7p98np 145 84 treatments treatment NNS cord-274510-fo7p98np 145 85 for for IN cord-274510-fo7p98np 145 86 COVID-19 covid-19 NN cord-274510-fo7p98np 145 87 : : : cord-274510-fo7p98np 145 88 what what WP cord-274510-fo7p98np 145 89 's be VBZ cord-274510-fo7p98np 145 90 next next JJ cord-274510-fo7p98np 145 91 ? ? . cord-274510-fo7p98np 146 1 Treatment treatment NN cord-274510-fo7p98np 146 2 options option NNS cord-274510-fo7p98np 146 3 for for IN cord-274510-fo7p98np 146 4 COVID-19 covid-19 NN cord-274510-fo7p98np 146 5 : : : cord-274510-fo7p98np 147 1 The the DT cord-274510-fo7p98np 147 2 reality reality NN cord-274510-fo7p98np 147 3 and and CC cord-274510-fo7p98np 147 4 challenges challenge VBZ cord-274510-fo7p98np 147 5 Comparison comparison NN cord-274510-fo7p98np 147 6 of of IN cord-274510-fo7p98np 147 7 the the DT cord-274510-fo7p98np 147 8 Antiviral Antiviral NNP cord-274510-fo7p98np 147 9 Activity Activity NNP cord-274510-fo7p98np 147 10 in in IN cord-274510-fo7p98np 147 11 Vitro Vitro NNP cord-274510-fo7p98np 147 12 of of IN cord-274510-fo7p98np 147 13 Some some DT cord-274510-fo7p98np 147 14 Non Non NNP cord-274510-fo7p98np 147 15 - - NNP cord-274510-fo7p98np 147 16 Steroidal steroidal JJ cord-274510-fo7p98np 147 17 Anti anti JJ cord-274510-fo7p98np 147 18 - - JJ cord-274510-fo7p98np 147 19 Inflammatory inflammatory JJ cord-274510-fo7p98np 147 20 Drugs drug NNS cord-274510-fo7p98np 147 21 Of of IN cord-274510-fo7p98np 147 22 chloroquine chloroquine NN cord-274510-fo7p98np 147 23 and and CC cord-274510-fo7p98np 147 24 COVID-19 COVID-19 NNP cord-274510-fo7p98np 147 25 Breakthrough Breakthrough NNP cord-274510-fo7p98np 148 1 : : : cord-274510-fo7p98np 148 2 Chloroquine Chloroquine NNP cord-274510-fo7p98np 148 3 Phosphate Phosphate NNP cord-274510-fo7p98np 148 4 Has have VBZ cord-274510-fo7p98np 148 5 Shown show VBN cord-274510-fo7p98np 148 6 Apparent Apparent NNP cord-274510-fo7p98np 148 7 Efficacy Efficacy NNP cord-274510-fo7p98np 148 8 in in IN cord-274510-fo7p98np 148 9 Treatment Treatment NNP cord-274510-fo7p98np 148 10 of of IN cord-274510-fo7p98np 148 11 COVID-19 COVID-19 NNP cord-274510-fo7p98np 148 12 Associated Associated NNP cord-274510-fo7p98np 148 13 Pneumonia Pneumonia NNP cord-274510-fo7p98np 148 14 in in IN cord-274510-fo7p98np 148 15 Clinical Clinical NNP cord-274510-fo7p98np 148 16 Studies Studies NNPS cord-274510-fo7p98np 148 17 Current Current NNP cord-274510-fo7p98np 148 18 and and CC cord-274510-fo7p98np 148 19 emerging emerge VBG cord-274510-fo7p98np 148 20 treatment treatment NN cord-274510-fo7p98np 148 21 options option NNS cord-274510-fo7p98np 148 22 in in IN cord-274510-fo7p98np 148 23 the the DT cord-274510-fo7p98np 148 24 management management NN cord-274510-fo7p98np 148 25 of of IN cord-274510-fo7p98np 148 26 lupus lupus NNP cord-274510-fo7p98np 148 27 Chloroquine Chloroquine NNP cord-274510-fo7p98np 148 28 intoxication intoxication NN cord-274510-fo7p98np 149 1 Tocilizumab Tocilizumab NNP cord-274510-fo7p98np 149 2 : : : cord-274510-fo7p98np 149 3 a a DT cord-274510-fo7p98np 149 4 review review NN cord-274510-fo7p98np 149 5 of of IN cord-274510-fo7p98np 149 6 its -PRON- PRP$ cord-274510-fo7p98np 149 7 use use NN cord-274510-fo7p98np 149 8 in in IN cord-274510-fo7p98np 149 9 the the DT cord-274510-fo7p98np 149 10 management management NN cord-274510-fo7p98np 149 11 of of IN cord-274510-fo7p98np 149 12 rheumatoid rheumatoid NNP cord-274510-fo7p98np 149 13 arthritis arthritis NN cord-274510-fo7p98np 149 14 -Identifier -Identifier . cord-274510-fo7p98np 149 15 : : : cord-274510-fo7p98np 149 16 NCT04320615 NCT04320615 NNP cord-274510-fo7p98np 149 17 , , , cord-274510-fo7p98np 150 1 A a DT cord-274510-fo7p98np 150 2 Study study NN cord-274510-fo7p98np 150 3 to to TO cord-274510-fo7p98np 150 4 Evaluate evaluate VB cord-274510-fo7p98np 150 5 the the DT cord-274510-fo7p98np 150 6 Safety Safety NNP cord-274510-fo7p98np 150 7 and and CC cord-274510-fo7p98np 150 8 Efficacy Efficacy NNP cord-274510-fo7p98np 150 9 of of IN cord-274510-fo7p98np 150 10 Tocilizumab Tocilizumab NNP cord-274510-fo7p98np 150 11 in in IN cord-274510-fo7p98np 150 12 Patients patient NNS cord-274510-fo7p98np 150 13 With with IN cord-274510-fo7p98np 150 14 Severe severe JJ cord-274510-fo7p98np 150 15 COVID-19 COVID-19 NNP cord-274510-fo7p98np 150 16 Pneumonia Pneumonia NNP cord-274510-fo7p98np 150 17 ( ( -LRB- cord-274510-fo7p98np 150 18 COVACTA COVACTA NNP cord-274510-fo7p98np 150 19 ) ) -RRB- cord-274510-fo7p98np 151 1 Biological biological JJ cord-274510-fo7p98np 151 2 activity activity NN cord-274510-fo7p98np 151 3 of of IN cord-274510-fo7p98np 151 4 bevacizumab bevacizumab NNP cord-274510-fo7p98np 151 5 , , , cord-274510-fo7p98np 151 6 a a DT cord-274510-fo7p98np 151 7 humanized humanize VBN cord-274510-fo7p98np 151 8 anti anti JJ cord-274510-fo7p98np 151 9 - - JJ cord-274510-fo7p98np 151 10 VEGF vegf JJ cord-274510-fo7p98np 151 11 antibody antibody NN cord-274510-fo7p98np 151 12 in in IN cord-274510-fo7p98np 151 13 vitro vitro NNP cord-274510-fo7p98np 152 1 -Identifier -Identifier . cord-274510-fo7p98np 153 1 NCT04275414 NCT04275414 NNP cord-274510-fo7p98np 154 1 , , , cord-274510-fo7p98np 154 2 Bevacizumab Bevacizumab NNP cord-274510-fo7p98np 154 3 in in IN cord-274510-fo7p98np 154 4 severe severe JJ cord-274510-fo7p98np 154 5 or or CC cord-274510-fo7p98np 154 6 critical critical JJ cord-274510-fo7p98np 154 7 patients patient NNS cord-274510-fo7p98np 154 8 with with IN cord-274510-fo7p98np 154 9 Covid-19 covid-19 JJ cord-274510-fo7p98np 154 10 pneumonia pneumonia NN cord-274510-fo7p98np 154 11 ( ( -LRB- cord-274510-fo7p98np 154 12 BEST best JJ cord-274510-fo7p98np 154 13 - - HYPH cord-274510-fo7p98np 154 14 CP cp NN cord-274510-fo7p98np 154 15 ) ) -RRB- cord-274510-fo7p98np 155 1 National National NNP cord-274510-fo7p98np 155 2 Library Library NNP cord-274510-fo7p98np 155 3 of of IN cord-274510-fo7p98np 155 4 Medicine Medicine NNP cord-274510-fo7p98np 155 5 ( ( -LRB- cord-274510-fo7p98np 155 6 US US NNP cord-274510-fo7p98np 155 7 ) ) -RRB- cord-274510-fo7p98np 156 1 Ocular ocular JJ cord-274510-fo7p98np 156 2 toxicity toxicity NN cord-274510-fo7p98np 156 3 of of IN cord-274510-fo7p98np 156 4 hydroxychloroquine hydroxychloroquine NN cord-274510-fo7p98np 156 5 Use Use NNP cord-274510-fo7p98np 156 6 of of IN cord-274510-fo7p98np 156 7 tocilizumab tocilizumab NNP cord-274510-fo7p98np 156 8 for for IN cord-274510-fo7p98np 156 9 COVID-19 COVID-19 NNP cord-274510-fo7p98np 156 10 infection infection NN cord-274510-fo7p98np 156 11 - - HYPH cord-274510-fo7p98np 156 12 induced induce VBN cord-274510-fo7p98np 156 13 cytokine cytokine NN cord-274510-fo7p98np 156 14 release release NN cord-274510-fo7p98np 156 15 syndrome syndrome NN cord-274510-fo7p98np 156 16 : : : cord-274510-fo7p98np 157 1 A a DT cord-274510-fo7p98np 157 2 cautionary cautionary JJ cord-274510-fo7p98np 157 3 case case NN cord-274510-fo7p98np 157 4 report report NN cord-274510-fo7p98np 157 5 Letter Letter NNP cord-274510-fo7p98np 157 6 to to IN cord-274510-fo7p98np 157 7 the the DT cord-274510-fo7p98np 157 8 Editor editor NN cord-274510-fo7p98np 157 9 : : : cord-274510-fo7p98np 158 1 Lipemic Lipemic NNP cord-274510-fo7p98np 158 2 serum serum NN cord-274510-fo7p98np 158 3 in in IN cord-274510-fo7p98np 158 4 patients patient NNS cord-274510-fo7p98np 158 5 with with IN cord-274510-fo7p98np 158 6 COVID-19 covid-19 DT cord-274510-fo7p98np 158 7 undergoing undergo VBG cord-274510-fo7p98np 158 8 treatment treatment NN cord-274510-fo7p98np 158 9 Rational rational JJ cord-274510-fo7p98np 158 10 Use Use NNP cord-274510-fo7p98np 158 11 of of IN cord-274510-fo7p98np 158 12 Tocilizumab Tocilizumab NNP cord-274510-fo7p98np 158 13 in in IN cord-274510-fo7p98np 158 14 the the DT cord-274510-fo7p98np 158 15 Treatment Treatment NNP cord-274510-fo7p98np 158 16 of of IN cord-274510-fo7p98np 158 17 Novel Novel NNP cord-274510-fo7p98np 158 18 Coronavirus Coronavirus NNP cord-274510-fo7p98np 158 19 Pneumonia Pneumonia NNP