id sid tid token lemma pos cord-265322-3854ddb9 1 1 key key NN cord-265322-3854ddb9 1 2 : : : cord-265322-3854ddb9 2 1 cord-265322 cord-265322 NNP cord-265322-3854ddb9 2 2 - - HYPH cord-265322-3854ddb9 2 3 3854ddb9 3854ddb9 CD cord-265322-3854ddb9 2 4 authors author NNS cord-265322-3854ddb9 2 5 : : : cord-265322-3854ddb9 2 6 Vavougios Vavougios NNP cord-265322-3854ddb9 2 7 , , , cord-265322-3854ddb9 2 8 George George NNP cord-265322-3854ddb9 2 9 D. D. NNP cord-265322-3854ddb9 2 10 title title NN cord-265322-3854ddb9 2 11 : : : cord-265322-3854ddb9 2 12 A a DT cord-265322-3854ddb9 2 13 data data NN cord-265322-3854ddb9 2 14 - - HYPH cord-265322-3854ddb9 2 15 driven drive VBN cord-265322-3854ddb9 2 16 hypothesis hypothesis NN cord-265322-3854ddb9 2 17 on on IN cord-265322-3854ddb9 2 18 the the DT cord-265322-3854ddb9 2 19 epigenetic epigenetic JJ cord-265322-3854ddb9 2 20 dysregulation dysregulation NN cord-265322-3854ddb9 2 21 of of IN cord-265322-3854ddb9 2 22 host host NN cord-265322-3854ddb9 2 23 metabolism metabolism NN cord-265322-3854ddb9 2 24 by by IN cord-265322-3854ddb9 2 25 SARS SARS NNP cord-265322-3854ddb9 2 26 coronaviral coronaviral NNP cord-265322-3854ddb9 2 27 infection infection NN cord-265322-3854ddb9 2 28 : : : cord-265322-3854ddb9 2 29 potential potential JJ cord-265322-3854ddb9 2 30 implications implication NNS cord-265322-3854ddb9 2 31 for for IN cord-265322-3854ddb9 2 32 the the DT cord-265322-3854ddb9 2 33 SARS SARS NNP cord-265322-3854ddb9 2 34 - - HYPH cord-265322-3854ddb9 2 35 CoV-2 CoV-2 NNP cord-265322-3854ddb9 2 36 modus modus NN cord-265322-3854ddb9 2 37 operandi operandi NN cord-265322-3854ddb9 2 38 date date NN cord-265322-3854ddb9 2 39 : : : cord-265322-3854ddb9 2 40 2020 2020 CD cord-265322-3854ddb9 2 41 - - HYPH cord-265322-3854ddb9 2 42 04 04 CD cord-265322-3854ddb9 2 43 - - HYPH cord-265322-3854ddb9 2 44 23 23 CD cord-265322-3854ddb9 2 45 journal journal NN cord-265322-3854ddb9 2 46 : : : cord-265322-3854ddb9 3 1 Med Med NNP cord-265322-3854ddb9 3 2 Hypotheses Hypotheses NNP cord-265322-3854ddb9 3 3 DOI DOI NNP cord-265322-3854ddb9 3 4 : : : cord-265322-3854ddb9 3 5 10.1016/ 10.1016/ CD cord-265322-3854ddb9 4 1 j.mehy.2020.109759 j.mehy.2020.109759 . cord-265322-3854ddb9 5 1 sha sha NNP cord-265322-3854ddb9 5 2 : : : cord-265322-3854ddb9 6 1 3602172f70e41a6365abd164e90f0588c73114aa 3602172f70e41a6365abd164e90f0588c73114aa CC cord-265322-3854ddb9 6 2 doc_id doc_id CD cord-265322-3854ddb9 6 3 : : : cord-265322-3854ddb9 6 4 265322 265322 CD cord-265322-3854ddb9 6 5 cord_uid cord_uid NNS cord-265322-3854ddb9 6 6 : : : cord-265322-3854ddb9 6 7 3854ddb9 3854ddb9 NNP cord-265322-3854ddb9 7 1 COVID-19 covid-19 VB cord-265322-3854ddb9 7 2 , , , cord-265322-3854ddb9 7 3 the the DT cord-265322-3854ddb9 7 4 disease disease NN cord-265322-3854ddb9 7 5 caused cause VBN cord-265322-3854ddb9 7 6 by by IN cord-265322-3854ddb9 7 7 the the DT cord-265322-3854ddb9 7 8 novel novel JJ cord-265322-3854ddb9 7 9 SARS SARS NNP cord-265322-3854ddb9 7 10 - - HYPH cord-265322-3854ddb9 7 11 CoV-2 CoV-2 NNP cord-265322-3854ddb9 7 12 , , , cord-265322-3854ddb9 7 13 a a DT cord-265322-3854ddb9 7 14 betacoronavirus betacoronavirus NN cord-265322-3854ddb9 7 15 structurally structurally RB cord-265322-3854ddb9 7 16 similar similar JJ cord-265322-3854ddb9 7 17 to to IN cord-265322-3854ddb9 7 18 SARS SARS NNP cord-265322-3854ddb9 7 19 - - HYPH cord-265322-3854ddb9 7 20 CoV. CoV. NNP cord-265322-3854ddb9 8 1 Based base VBN cord-265322-3854ddb9 8 2 on on IN cord-265322-3854ddb9 8 3 both both DT cord-265322-3854ddb9 8 4 structural structural JJ cord-265322-3854ddb9 8 5 and and CC cord-265322-3854ddb9 8 6 syndromic syndromic JJ cord-265322-3854ddb9 8 7 similarities similarity NNS cord-265322-3854ddb9 8 8 with with IN cord-265322-3854ddb9 8 9 SARS SARS NNP cord-265322-3854ddb9 8 10 - - HYPH cord-265322-3854ddb9 8 11 CoV CoV NNP cord-265322-3854ddb9 8 12 , , , cord-265322-3854ddb9 8 13 a a DT cord-265322-3854ddb9 8 14 hypothesis hypothesis NN cord-265322-3854ddb9 8 15 is be VBZ cord-265322-3854ddb9 8 16 formed form VBN cord-265322-3854ddb9 8 17 on on IN cord-265322-3854ddb9 8 18 SARS SARS NNP cord-265322-3854ddb9 8 19 - - HYPH cord-265322-3854ddb9 8 20 CoV-2 CoV-2 NNP cord-265322-3854ddb9 8 21 potential potential NN cord-265322-3854ddb9 8 22 to to TO cord-265322-3854ddb9 8 23 affect affect VB cord-265322-3854ddb9 8 24 the the DT cord-265322-3854ddb9 8 25 host host NN cord-265322-3854ddb9 8 26 ’s ’s POS cord-265322-3854ddb9 8 27 metabolism metabolism NN cord-265322-3854ddb9 8 28 as as IN cord-265322-3854ddb9 8 29 part part NN cord-265322-3854ddb9 8 30 of of IN cord-265322-3854ddb9 8 31 its -PRON- PRP$ cord-265322-3854ddb9 8 32 lifecycle lifecycle NN cord-265322-3854ddb9 8 33 . . . cord-265322-3854ddb9 9 1 This this DT cord-265322-3854ddb9 9 2 hypothesis hypothesis NN cord-265322-3854ddb9 9 3 is be VBZ cord-265322-3854ddb9 9 4 evaluated evaluate VBN cord-265322-3854ddb9 9 5 by by IN cord-265322-3854ddb9 9 6 ( ( -LRB- cord-265322-3854ddb9 9 7 a a DT cord-265322-3854ddb9 9 8 ) ) -RRB- cord-265322-3854ddb9 9 9 exploratory exploratory JJ cord-265322-3854ddb9 9 10 analysis analysis NN cord-265322-3854ddb9 9 11 of of IN cord-265322-3854ddb9 9 12 SARS SARS NNP cord-265322-3854ddb9 9 13 - - HYPH cord-265322-3854ddb9 9 14 CoV CoV NNP cord-265322-3854ddb9 9 15 / / SYM cord-265322-3854ddb9 9 16 human human JJ cord-265322-3854ddb9 9 17 transcriptomic transcriptomic JJ cord-265322-3854ddb9 9 18 interaction interaction NN cord-265322-3854ddb9 9 19 data datum NNS cord-265322-3854ddb9 9 20 and and CC cord-265322-3854ddb9 9 21 gene gene NN cord-265322-3854ddb9 9 22 set set VBD cord-265322-3854ddb9 9 23 enrichment enrichment NN cord-265322-3854ddb9 9 24 analysis analysis NN cord-265322-3854ddb9 9 25 ( ( -LRB- cord-265322-3854ddb9 9 26 b b NN cord-265322-3854ddb9 9 27 ) ) -RRB- cord-265322-3854ddb9 9 28 a a DT cord-265322-3854ddb9 9 29 confirmatory confirmatory NN cord-265322-3854ddb9 9 30 , , , cord-265322-3854ddb9 9 31 focused focused JJ cord-265322-3854ddb9 9 32 review review NN cord-265322-3854ddb9 9 33 of of IN cord-265322-3854ddb9 9 34 the the DT cord-265322-3854ddb9 9 35 literature literature NN cord-265322-3854ddb9 9 36 based base VBN cord-265322-3854ddb9 9 37 on on IN cord-265322-3854ddb9 9 38 the the DT cord-265322-3854ddb9 9 39 findings finding NNS cord-265322-3854ddb9 9 40 by by IN cord-265322-3854ddb9 9 41 ( ( -LRB- cord-265322-3854ddb9 9 42 a a LS cord-265322-3854ddb9 9 43 ) ) -RRB- cord-265322-3854ddb9 9 44 . . . cord-265322-3854ddb9 10 1 A a DT cord-265322-3854ddb9 10 2 STRING string NN cord-265322-3854ddb9 10 3 Viruses virus NNS cord-265322-3854ddb9 10 4 ( ( -LRB- cord-265322-3854ddb9 10 5 available available JJ cord-265322-3854ddb9 10 6 search search NN cord-265322-3854ddb9 10 7 for for IN cord-265322-3854ddb9 10 8 human human NN cord-265322-3854ddb9 10 9 – – : cord-265322-3854ddb9 10 10 SARS SARS NNP cord-265322-3854ddb9 10 11 - - HYPH cord-265322-3854ddb9 10 12 CoV CoV NNP cord-265322-3854ddb9 10 13 ( ( -LRB- cord-265322-3854ddb9 10 14 NCBI NCBI NNP cord-265322-3854ddb9 10 15 taxonomy taxonomy NN cord-265322-3854ddb9 11 1 I -PRON- PRP cord-265322-3854ddb9 11 2 d d NN cord-265322-3854ddb9 11 3 : : : cord-265322-3854ddb9 11 4 9606 9606 CD cord-265322-3854ddb9 11 5 vs. vs. IN cord-265322-3854ddb9 11 6 NCBI NCBI NNP cord-265322-3854ddb9 11 7 taxonomy taxonomy NN cord-265322-3854ddb9 11 8 I -PRON- PRP cord-265322-3854ddb9 11 9 d d NN cord-265322-3854ddb9 11 10 : : : cord-265322-3854ddb9 11 11 694009 694009 CD cord-265322-3854ddb9 11 12 ) ) -RRB- cord-265322-3854ddb9 12 1 genomic genomic JJ cord-265322-3854ddb9 12 2 interactions interaction NNS cord-265322-3854ddb9 12 3 reveals reveal VBZ cord-265322-3854ddb9 12 4 ten ten CD cord-265322-3854ddb9 12 5 human human JJ cord-265322-3854ddb9 12 6 proteins protein NNS cord-265322-3854ddb9 12 7 , , , cord-265322-3854ddb9 12 8 interacting interact VBG cord-265322-3854ddb9 12 9 with with IN cord-265322-3854ddb9 12 10 SARS SARS NNP cord-265322-3854ddb9 12 11 - - HYPH cord-265322-3854ddb9 12 12 CoV CoV NNP cord-265322-3854ddb9 12 13 : : : cord-265322-3854ddb9 12 14 SGTA SGTA NNP cord-265322-3854ddb9 12 15 , , , cord-265322-3854ddb9 12 16 FGL2 FGL2 NNP cord-265322-3854ddb9 12 17 , , , cord-265322-3854ddb9 12 18 SPECC1 SPECC1 NNP cord-265322-3854ddb9 12 19 , , , cord-265322-3854ddb9 12 20 STAT3 STAT3 NNP cord-265322-3854ddb9 12 21 , , , cord-265322-3854ddb9 12 22 PHB PHB NNP cord-265322-3854ddb9 12 23 , , , cord-265322-3854ddb9 12 24 BCL2L1 BCL2L1 NNP cord-265322-3854ddb9 12 25 , , , cord-265322-3854ddb9 12 26 PPP1CA PPP1CA NNP cord-265322-3854ddb9 12 27 , , , cord-265322-3854ddb9 12 28 CAV1 CAV1 NNP cord-265322-3854ddb9 12 29 , , , cord-265322-3854ddb9 12 30 JUN JUN NNP cord-265322-3854ddb9 12 31 , , , cord-265322-3854ddb9 12 32 XPO1 XPO1 NNPS cord-265322-3854ddb9 12 33 . . . cord-265322-3854ddb9 13 1 Gene gene NN cord-265322-3854ddb9 13 2 set set VBD cord-265322-3854ddb9 13 3 enrichment enrichment NN cord-265322-3854ddb9 13 4 analyses analysis NNS cord-265322-3854ddb9 13 5 ( ( -LRB- cord-265322-3854ddb9 13 6 GSEA GSEA NNP cord-265322-3854ddb9 13 7 ) ) -RRB- cord-265322-3854ddb9 13 8 with with IN cord-265322-3854ddb9 13 9 STRING string NN cord-265322-3854ddb9 13 10 on on IN cord-265322-3854ddb9 13 11 this this DT cord-265322-3854ddb9 13 12 network network NN cord-265322-3854ddb9 13 13 revealed reveal VBD cord-265322-3854ddb9 13 14 their -PRON- PRP$ cord-265322-3854ddb9 13 15 role role NN cord-265322-3854ddb9 13 16 as as IN cord-265322-3854ddb9 13 17 a a DT cord-265322-3854ddb9 13 18 putative putative JJ cord-265322-3854ddb9 13 19 protein protein NN cord-265322-3854ddb9 13 20 – – : cord-265322-3854ddb9 13 21 protein protein NN cord-265322-3854ddb9 13 22 interaction interaction NN cord-265322-3854ddb9 13 23 network network NN cord-265322-3854ddb9 13 24 ( ( -LRB- cord-265322-3854ddb9 13 25 PPI PPI NNP cord-265322-3854ddb9 13 26 ; ; : cord-265322-3854ddb9 13 27 Enrichment enrichment NN cord-265322-3854ddb9 13 28 p p NN cord-265322-3854ddb9 13 29 - - HYPH cord-265322-3854ddb9 13 30 value=0.0296 value=0.0296 NNP cord-265322-3854ddb9 13 31 ) ) -RRB- cord-265322-3854ddb9 13 32 mediating mediate VBG cord-265322-3854ddb9 13 33 , , , cord-265322-3854ddb9 13 34 viral viral JJ cord-265322-3854ddb9 13 35 parasitism parasitism NN cord-265322-3854ddb9 13 36 , , , cord-265322-3854ddb9 13 37 interleukin interleukin NN cord-265322-3854ddb9 13 38 as as RB cord-265322-3854ddb9 13 39 well well RB cord-265322-3854ddb9 13 40 as as IN cord-265322-3854ddb9 13 41 insulin insulin NN cord-265322-3854ddb9 13 42 signaling signaling NN cord-265322-3854ddb9 13 43 , , , cord-265322-3854ddb9 13 44 diabetes diabetes NN cord-265322-3854ddb9 13 45 and and CC cord-265322-3854ddb9 13 46 triglyceride triglyceride NN cord-265322-3854ddb9 13 47 catabolism catabolism NN cord-265322-3854ddb9 13 48 . . . cord-265322-3854ddb9 14 1 In in IN cord-265322-3854ddb9 14 2 the the DT cord-265322-3854ddb9 14 3 literature literature NN cord-265322-3854ddb9 14 4 , , , cord-265322-3854ddb9 14 5 SARS SARS NNP cord-265322-3854ddb9 14 6 - - HYPH cord-265322-3854ddb9 14 7 CoV CoV NNP cord-265322-3854ddb9 14 8 has have VBZ cord-265322-3854ddb9 14 9 been be VBN cord-265322-3854ddb9 14 10 known know VBN cord-265322-3854ddb9 14 11 to to TO cord-265322-3854ddb9 14 12 cause cause VB cord-265322-3854ddb9 14 13 de de FW cord-265322-3854ddb9 14 14 novo novo NNP cord-265322-3854ddb9 14 15 diabetes diabete NNS cord-265322-3854ddb9 14 16 by by IN cord-265322-3854ddb9 14 17 ACE2-dependent ACE2-dependent NNP cord-265322-3854ddb9 14 18 uptake uptake NN cord-265322-3854ddb9 14 19 on on IN cord-265322-3854ddb9 14 20 pancreatic pancreatic JJ cord-265322-3854ddb9 14 21 isle isle NNP cord-265322-3854ddb9 14 22 cells cell NNS cord-265322-3854ddb9 14 23 , , , cord-265322-3854ddb9 14 24 and and CC cord-265322-3854ddb9 14 25 furthermore furthermore RB cord-265322-3854ddb9 14 26 dysregulate dysregulate VBP cord-265322-3854ddb9 14 27 lipid lipid NN cord-265322-3854ddb9 14 28 autophagy autophagy NN cord-265322-3854ddb9 14 29 in in IN cord-265322-3854ddb9 14 30 favor favor NN cord-265322-3854ddb9 14 31 of of IN cord-265322-3854ddb9 14 32 the the DT cord-265322-3854ddb9 14 33 viral viral JJ cord-265322-3854ddb9 14 34 lifecycle lifecycle NN cord-265322-3854ddb9 14 35 . . . cord-265322-3854ddb9 15 1 Conversely conversely RB cord-265322-3854ddb9 15 2 , , , cord-265322-3854ddb9 15 3 currently currently RB cord-265322-3854ddb9 15 4 there there EX cord-265322-3854ddb9 15 5 are be VBP cord-265322-3854ddb9 15 6 only only RB cord-265322-3854ddb9 15 7 non non JJ cord-265322-3854ddb9 15 8 - - JJ cord-265322-3854ddb9 15 9 causative causative JJ cord-265322-3854ddb9 15 10 , , , cord-265322-3854ddb9 15 11 observational observational JJ cord-265322-3854ddb9 15 12 evidence evidence NN cord-265322-3854ddb9 15 13 of of IN cord-265322-3854ddb9 15 14 worse bad JJR cord-265322-3854ddb9 15 15 outcomes outcome NNS cord-265322-3854ddb9 15 16 for for IN cord-265322-3854ddb9 15 17 COVID-19 covid-19 JJ cord-265322-3854ddb9 15 18 patients patient NNS cord-265322-3854ddb9 15 19 with with IN cord-265322-3854ddb9 15 20 comorbid comorbid NN cord-265322-3854ddb9 15 21 diabetes diabete NNS cord-265322-3854ddb9 15 22 or or CC cord-265322-3854ddb9 15 23 hyperglycemia hyperglycemia NN cord-265322-3854ddb9 15 24 . . . cord-265322-3854ddb9 16 1 No no DT cord-265322-3854ddb9 16 2 study study NN cord-265322-3854ddb9 16 3 has have VBZ cord-265322-3854ddb9 16 4 reported report VBN cord-265322-3854ddb9 16 5 on on IN cord-265322-3854ddb9 16 6 the the DT cord-265322-3854ddb9 16 7 lipid lipid NN cord-265322-3854ddb9 16 8 profiles profile NNS cord-265322-3854ddb9 16 9 of of IN cord-265322-3854ddb9 16 10 COVID-19 covid-19 JJ cord-265322-3854ddb9 16 11 patients patient NNS cord-265322-3854ddb9 16 12 ; ; : cord-265322-3854ddb9 16 13 however however RB cord-265322-3854ddb9 16 14 , , , cord-265322-3854ddb9 16 15 lipid lipid NN cord-265322-3854ddb9 16 16 - - HYPH cord-265322-3854ddb9 16 17 targeting target VBG cord-265322-3854ddb9 16 18 molecules molecule NNS cord-265322-3854ddb9 16 19 have have VBP cord-265322-3854ddb9 16 20 been be VBN cord-265322-3854ddb9 16 21 proposed propose VBN cord-265322-3854ddb9 16 22 as as IN cord-265322-3854ddb9 16 23 agents agent NNS cord-265322-3854ddb9 16 24 against against IN cord-265322-3854ddb9 16 25 SARS SARS NNP cord-265322-3854ddb9 16 26 - - HYPH cord-265322-3854ddb9 16 27 CoV-2 CoV-2 NNP cord-265322-3854ddb9 16 28 . . . cord-265322-3854ddb9 17 1 Future future JJ cord-265322-3854ddb9 17 2 studies study NNS cord-265322-3854ddb9 17 3 , , , cord-265322-3854ddb9 17 4 reporting report VBG cord-265322-3854ddb9 17 5 on on IN cord-265322-3854ddb9 17 6 lipid lipid NN cord-265322-3854ddb9 17 7 and and CC cord-265322-3854ddb9 17 8 glucose glucose NN cord-265322-3854ddb9 17 9 metabolism metabolism NN cord-265322-3854ddb9 17 10 of of IN cord-265322-3854ddb9 17 11 COVID-19 covid-19 JJ cord-265322-3854ddb9 17 12 patients patient NNS cord-265322-3854ddb9 17 13 could could MD cord-265322-3854ddb9 17 14 help help VB cord-265322-3854ddb9 17 15 elucidate elucidate VB cord-265322-3854ddb9 17 16 the the DT cord-265322-3854ddb9 17 17 disease disease NN cord-265322-3854ddb9 17 18 ’s ’s POS cord-265322-3854ddb9 17 19 seculae seculae NN cord-265322-3854ddb9 17 20 and and CC cord-265322-3854ddb9 17 21 aid aid NN cord-265322-3854ddb9 17 22 drug drug NN cord-265322-3854ddb9 17 23 design design NN cord-265322-3854ddb9 17 24 . . . cord-265322-3854ddb9 17 25 . . . cord-265322-3854ddb9 18 1 COVID-19 COVID-19 NNP cord-265322-3854ddb9 18 2 is be VBZ cord-265322-3854ddb9 18 3 caused cause VBN cord-265322-3854ddb9 18 4 by by IN cord-265322-3854ddb9 18 5 the the DT cord-265322-3854ddb9 18 6 novel novel JJ cord-265322-3854ddb9 18 7 SARS SARS NNP cord-265322-3854ddb9 18 8 - - HYPH cord-265322-3854ddb9 18 9 CoV-2 CoV-2 NNP cord-265322-3854ddb9 18 10 , , , cord-265322-3854ddb9 18 11 a a DT cord-265322-3854ddb9 18 12 betacoronavirus betacoronavirus NN cord-265322-3854ddb9 18 13 structurally structurally RB cord-265322-3854ddb9 18 14 similar similar JJ cord-265322-3854ddb9 18 15 ( ( -LRB- cord-265322-3854ddb9 18 16 approximately approximately RB cord-265322-3854ddb9 18 17 79 79 CD cord-265322-3854ddb9 18 18 % % NN cord-265322-3854ddb9 18 19 ) ) -RRB- cord-265322-3854ddb9 18 20 to to IN cord-265322-3854ddb9 18 21 SARS SARS NNP cord-265322-3854ddb9 18 22 - - HYPH cord-265322-3854ddb9 18 23 CoV CoV NNP cord-265322-3854ddb9 18 24 ( ( -LRB- cord-265322-3854ddb9 18 25 2 2 CD cord-265322-3854ddb9 18 26 ) ) -RRB- cord-265322-3854ddb9 18 27 . . . cord-265322-3854ddb9 19 1 In in IN cord-265322-3854ddb9 19 2 a a DT cord-265322-3854ddb9 19 3 recent recent JJ cord-265322-3854ddb9 19 4 study study NN cord-265322-3854ddb9 19 5 by by IN cord-265322-3854ddb9 19 6 Hoffmann Hoffmann NNP cord-265322-3854ddb9 19 7 et et NNP cord-265322-3854ddb9 19 8 al al NNP cord-265322-3854ddb9 19 9 . . . cord-265322-3854ddb9 20 1 ( ( -LRB- cord-265322-3854ddb9 20 2 3 3 LS cord-265322-3854ddb9 20 3 ) ) -RRB- cord-265322-3854ddb9 20 4 , , , cord-265322-3854ddb9 20 5 the the DT cord-265322-3854ddb9 20 6 similarities similarity NNS cord-265322-3854ddb9 20 7 between between IN cord-265322-3854ddb9 20 8 the the DT cord-265322-3854ddb9 20 9 SARS SARS NNP cord-265322-3854ddb9 20 10 viruses virus NNS cord-265322-3854ddb9 20 11 extend extend VBP cord-265322-3854ddb9 20 12 to to IN cord-265322-3854ddb9 20 13 ACE2 ACE2 NNP cord-265322-3854ddb9 20 14 dependent dependent JJ cord-265322-3854ddb9 20 15 host host NN cord-265322-3854ddb9 20 16 cell cell NN cord-265322-3854ddb9 20 17 entry entry NN cord-265322-3854ddb9 20 18 . . . cord-265322-3854ddb9 21 1 At at IN cord-265322-3854ddb9 21 2 present present NN cord-265322-3854ddb9 21 3 , , , cord-265322-3854ddb9 21 4 SARS SARS NNP cord-265322-3854ddb9 21 5 - - HYPH cord-265322-3854ddb9 21 6 CoV-2 CoV-2 NNP cord-265322-3854ddb9 21 7 has have VBZ cord-265322-3854ddb9 21 8 shown show VBN cord-265322-3854ddb9 21 9 significant significant JJ cord-265322-3854ddb9 21 10 similarities similarity NNS cord-265322-3854ddb9 21 11 with with IN cord-265322-3854ddb9 21 12 SARS SARS NNP cord-265322-3854ddb9 21 13 - - HYPH cord-265322-3854ddb9 21 14 CoV CoV NNP cord-265322-3854ddb9 21 15 , , , cord-265322-3854ddb9 21 16 both both CC cord-265322-3854ddb9 21 17 in in IN cord-265322-3854ddb9 21 18 clinical clinical JJ cord-265322-3854ddb9 21 19 characteristics characteristic NNS cord-265322-3854ddb9 21 20 and and CC cord-265322-3854ddb9 21 21 exploited exploit VBN cord-265322-3854ddb9 21 22 host host NN cord-265322-3854ddb9 21 23 intracellular intracellular JJ cord-265322-3854ddb9 21 24 functions function NNS cord-265322-3854ddb9 21 25 ( ( -LRB- cord-265322-3854ddb9 21 26 5 5 CD cord-265322-3854ddb9 21 27 ) ) -RRB- cord-265322-3854ddb9 21 28 . . . cord-265322-3854ddb9 22 1 Due due IN cord-265322-3854ddb9 22 2 to to IN cord-265322-3854ddb9 22 3 these these DT cord-265322-3854ddb9 22 4 commonalities commonality NNS cord-265322-3854ddb9 22 5 , , , cord-265322-3854ddb9 22 6 SARS SARS NNP cord-265322-3854ddb9 22 7 - - HYPH cord-265322-3854ddb9 22 8 CoV CoV NNP cord-265322-3854ddb9 22 9 remains remain VBZ cord-265322-3854ddb9 22 10 an an DT cord-265322-3854ddb9 22 11 attractive attractive JJ cord-265322-3854ddb9 22 12 substitute substitute NN cord-265322-3854ddb9 22 13 for for IN cord-265322-3854ddb9 22 14 the the DT cord-265322-3854ddb9 22 15 yet yet RB cord-265322-3854ddb9 22 16 to to TO cord-265322-3854ddb9 22 17 be be VB cord-265322-3854ddb9 22 18 determined determine VBN cord-265322-3854ddb9 22 19 specifics specific NNS cord-265322-3854ddb9 22 20 of of IN cord-265322-3854ddb9 22 21 the the DT cord-265322-3854ddb9 22 22 SARS SARS NNP cord-265322-3854ddb9 22 23 - - HYPH cord-265322-3854ddb9 22 24 CoV-2 CoV-2 NNP cord-265322-3854ddb9 22 25 / / SYM cord-265322-3854ddb9 22 26 Human human JJ cord-265322-3854ddb9 22 27 protein protein NN cord-265322-3854ddb9 22 28 interaction interaction NN cord-265322-3854ddb9 22 29 ( ( -LRB- cord-265322-3854ddb9 22 30 6 6 CD cord-265322-3854ddb9 22 31 ) ) -RRB- cord-265322-3854ddb9 22 32 and and CC cord-265322-3854ddb9 22 33 its -PRON- PRP$ cord-265322-3854ddb9 22 34 consequences consequence NNS cord-265322-3854ddb9 22 35 . . . cord-265322-3854ddb9 23 1 Among among IN cord-265322-3854ddb9 23 2 the the DT cord-265322-3854ddb9 23 3 first first JJ cord-265322-3854ddb9 23 4 studies study NNS cord-265322-3854ddb9 23 5 to to TO cord-265322-3854ddb9 23 6 report report VB cord-265322-3854ddb9 23 7 clinical clinical JJ cord-265322-3854ddb9 23 8 data datum NNS cord-265322-3854ddb9 23 9 on on IN cord-265322-3854ddb9 23 10 COVID19 COVID19 NNP cord-265322-3854ddb9 23 11 was be VBD cord-265322-3854ddb9 23 12 a a DT cord-265322-3854ddb9 23 13 recent recent JJ cord-265322-3854ddb9 23 14 publication publication NN cord-265322-3854ddb9 23 15 by by IN cord-265322-3854ddb9 23 16 Yang Yang NNP cord-265322-3854ddb9 23 17 and and CC cord-265322-3854ddb9 23 18 colleagues colleague NNS cord-265322-3854ddb9 23 19 ( ( -LRB- cord-265322-3854ddb9 23 20 6 6 CD cord-265322-3854ddb9 23 21 ) ) -RRB- cord-265322-3854ddb9 23 22 . . . cord-265322-3854ddb9 24 1 Their -PRON- PRP$ cord-265322-3854ddb9 24 2 study study NN cord-265322-3854ddb9 24 3 provided provide VBD cord-265322-3854ddb9 24 4 the the DT cord-265322-3854ddb9 24 5 foundation foundation NN cord-265322-3854ddb9 24 6 for for IN cord-265322-3854ddb9 24 7 a a DT cord-265322-3854ddb9 24 8 hypothesis hypothesis NN cord-265322-3854ddb9 24 9 put put VBN cord-265322-3854ddb9 24 10 forth forth RP cord-265322-3854ddb9 24 11 by by IN cord-265322-3854ddb9 24 12 Fang Fang NNP cord-265322-3854ddb9 24 13 and and CC cord-265322-3854ddb9 24 14 colleagues colleague NNS cord-265322-3854ddb9 24 15 indicating indicate VBG cord-265322-3854ddb9 24 16 that that IN cord-265322-3854ddb9 24 17 diabetic diabetic JJ cord-265322-3854ddb9 24 18 and and CC cord-265322-3854ddb9 24 19 hypertensive hypertensive JJ cord-265322-3854ddb9 24 20 patients patient NNS cord-265322-3854ddb9 24 21 exposed expose VBN cord-265322-3854ddb9 24 22 to to IN cord-265322-3854ddb9 24 23 ACE2 ACE2 NNP cord-265322-3854ddb9 24 24 inhibitors inhibitor NNS cord-265322-3854ddb9 24 25 may may MD cord-265322-3854ddb9 24 26 be be VB cord-265322-3854ddb9 24 27 at at IN cord-265322-3854ddb9 24 28 an an DT cord-265322-3854ddb9 24 29 increased increase VBN cord-265322-3854ddb9 24 30 risk risk NN cord-265322-3854ddb9 24 31 of of IN cord-265322-3854ddb9 24 32 more more RBR cord-265322-3854ddb9 24 33 severe severe JJ cord-265322-3854ddb9 24 34 COVID-19 COVID-19 NNP cord-265322-3854ddb9 24 35 ( ( -LRB- cord-265322-3854ddb9 24 36 7 7 CD cord-265322-3854ddb9 24 37 ) ) -RRB- cord-265322-3854ddb9 24 38 . . . cord-265322-3854ddb9 24 39 _SP cord-265322-3854ddb9 25 1 Meta Meta NNP cord-265322-3854ddb9 25 2 - - HYPH cord-265322-3854ddb9 25 3 analyses analysis NNS cord-265322-3854ddb9 25 4 on on IN cord-265322-3854ddb9 25 5 SARS SARS NNP cord-265322-3854ddb9 25 6 cohorts cohort NNS cord-265322-3854ddb9 25 7 have have VBP cord-265322-3854ddb9 25 8 indicated indicate VBN cord-265322-3854ddb9 25 9 that that IN cord-265322-3854ddb9 25 10 both both CC cord-265322-3854ddb9 25 11 a a DT cord-265322-3854ddb9 25 12 history history NN cord-265322-3854ddb9 25 13 of of IN cord-265322-3854ddb9 25 14 diabetes diabetes NN cord-265322-3854ddb9 25 15 and and CC cord-265322-3854ddb9 25 16 hyperglycemia hyperglycemia NN cord-265322-3854ddb9 25 17 were be VBD cord-265322-3854ddb9 25 18 independent independent JJ cord-265322-3854ddb9 25 19 factors factor NNS cord-265322-3854ddb9 25 20 of of IN cord-265322-3854ddb9 25 21 worse bad JJR cord-265322-3854ddb9 25 22 outcomes outcome NNS cord-265322-3854ddb9 25 23 including include VBG cord-265322-3854ddb9 25 24 more more RBR cord-265322-3854ddb9 25 25 severe severe JJ cord-265322-3854ddb9 25 26 respiratory respiratory JJ cord-265322-3854ddb9 25 27 symptoms symptom NNS cord-265322-3854ddb9 25 28 and and CC cord-265322-3854ddb9 25 29 death death NN cord-265322-3854ddb9 25 30 , , , cord-265322-3854ddb9 25 31 regardless regardless RB cord-265322-3854ddb9 25 32 of of IN cord-265322-3854ddb9 25 33 medication medication NN cord-265322-3854ddb9 25 34 ( ( -LRB- cord-265322-3854ddb9 25 35 9 9 CD cord-265322-3854ddb9 25 36 ) ) -RRB- cord-265322-3854ddb9 25 37 . . . cord-265322-3854ddb9 26 1 In in IN cord-265322-3854ddb9 26 2 another another DT cord-265322-3854ddb9 26 3 study study NN cord-265322-3854ddb9 26 4 , , , cord-265322-3854ddb9 26 5 SARS SARS NNP cord-265322-3854ddb9 26 6 - - HYPH cord-265322-3854ddb9 26 7 CoV CoV NNP cord-265322-3854ddb9 26 8 was be VBD cord-265322-3854ddb9 26 9 shown show VBN cord-265322-3854ddb9 26 10 to to TO cord-265322-3854ddb9 26 11 cause cause VB cord-265322-3854ddb9 26 12 diabetes diabete NNS cord-265322-3854ddb9 26 13 by by IN cord-265322-3854ddb9 26 14 ACE2-dependent ace2-dependent NN cord-265322-3854ddb9 26 15 infection infection NN cord-265322-3854ddb9 26 16 of of IN cord-265322-3854ddb9 26 17 pancreatic pancreatic JJ cord-265322-3854ddb9 26 18 isle isle NN cord-265322-3854ddb9 26 19 cells cell NNS cord-265322-3854ddb9 26 20 ( ( -LRB- cord-265322-3854ddb9 26 21 10 10 CD cord-265322-3854ddb9 26 22 ) ) -RRB- cord-265322-3854ddb9 26 23 . . . cord-265322-3854ddb9 27 1 Interestingly interestingly RB cord-265322-3854ddb9 27 2 , , , cord-265322-3854ddb9 27 3 the the DT cord-265322-3854ddb9 27 4 significantly significantly RB cord-265322-3854ddb9 27 5 enriched enrich VBN cord-265322-3854ddb9 27 6 " " '' cord-265322-3854ddb9 27 7 cAMP camp NN cord-265322-3854ddb9 27 8 signaling signal VBG cord-265322-3854ddb9 27 9 " " `` cord-265322-3854ddb9 27 10 pathway pathway NN cord-265322-3854ddb9 27 11 is be VBZ cord-265322-3854ddb9 27 12 an an DT cord-265322-3854ddb9 27 13 indirect indirect JJ cord-265322-3854ddb9 27 14 link link NN cord-265322-3854ddb9 27 15 between between IN cord-265322-3854ddb9 27 16 diabetes diabetes NN cord-265322-3854ddb9 27 17 and and CC cord-265322-3854ddb9 27 18 ACE2 ACE2 NNP cord-265322-3854ddb9 27 19 signaling signaling NN cord-265322-3854ddb9 27 20 , , , cord-265322-3854ddb9 27 21 based base VBN cord-265322-3854ddb9 27 22 on on IN cord-265322-3854ddb9 27 23 experimental experimental JJ cord-265322-3854ddb9 27 24 evidence evidence NN cord-265322-3854ddb9 27 25 associating associate VBG cord-265322-3854ddb9 27 26 cAMP camp NN cord-265322-3854ddb9 27 27 levels level NNS cord-265322-3854ddb9 27 28 and and CC cord-265322-3854ddb9 27 29 ACE2 ACE2 NNP cord-265322-3854ddb9 27 30 activity activity NN cord-265322-3854ddb9 27 31 in in IN cord-265322-3854ddb9 27 32 diabetic diabetic JJ cord-265322-3854ddb9 27 33 patients patient NNS cord-265322-3854ddb9 27 34 ( ( -LRB- cord-265322-3854ddb9 27 35 11 11 CD cord-265322-3854ddb9 27 36 ) ) -RRB- cord-265322-3854ddb9 28 1 ( ( -LRB- cord-265322-3854ddb9 28 2 False False NNP cord-265322-3854ddb9 28 3 Discovery Discovery NNP cord-265322-3854ddb9 28 4 Rate rate NN cord-265322-3854ddb9 28 5 ( ( -LRB- cord-265322-3854ddb9 28 6 FDR FDR NNP cord-265322-3854ddb9 28 7 ) ) -RRB- cord-265322-3854ddb9 28 8 < < XX cord-265322-3854ddb9 28 9 0.05 0.05 CD cord-265322-3854ddb9 28 10 ) ) -RRB- cord-265322-3854ddb9 28 11 ; ; : cord-265322-3854ddb9 28 12 Table table NN cord-265322-3854ddb9 28 13 1 1 CD cord-265322-3854ddb9 28 14 . . . cord-265322-3854ddb9 29 1 Following follow VBG cord-265322-3854ddb9 29 2 entry entry NN cord-265322-3854ddb9 29 3 to to IN cord-265322-3854ddb9 29 4 host host NN cord-265322-3854ddb9 29 5 cells cell NNS cord-265322-3854ddb9 29 6 , , , cord-265322-3854ddb9 29 7 lipid lipid NN cord-265322-3854ddb9 29 8 metabolism metabolism NN cord-265322-3854ddb9 29 9 is be VBZ cord-265322-3854ddb9 29 10 a a DT cord-265322-3854ddb9 29 11 subsequent subsequent JJ cord-265322-3854ddb9 29 12 important important JJ cord-265322-3854ddb9 29 13 target target NN cord-265322-3854ddb9 29 14 of of IN cord-265322-3854ddb9 29 15 single single JJ cord-265322-3854ddb9 29 16 strand strand NN cord-265322-3854ddb9 29 17 RNA RNA NNP cord-265322-3854ddb9 29 18 viruses virus NNS cord-265322-3854ddb9 29 19 , , , cord-265322-3854ddb9 29 20 critical critical JJ cord-265322-3854ddb9 29 21 for for IN cord-265322-3854ddb9 29 22 the the DT cord-265322-3854ddb9 29 23 formation formation NN cord-265322-3854ddb9 29 24 of of IN cord-265322-3854ddb9 29 25 the the DT cord-265322-3854ddb9 29 26 viral viral JJ cord-265322-3854ddb9 29 27 envelope envelope NN cord-265322-3854ddb9 29 28 in in IN cord-265322-3854ddb9 29 29 subsequent subsequent JJ cord-265322-3854ddb9 29 30 lifecycles lifecycle NNS cord-265322-3854ddb9 29 31 ( ( -LRB- cord-265322-3854ddb9 29 32 12 12 CD cord-265322-3854ddb9 29 33 ) ) -RRB- cord-265322-3854ddb9 29 34 . . . cord-265322-3854ddb9 30 1 Autophagy Autophagy NNP cord-265322-3854ddb9 30 2 mediated mediate VBD cord-265322-3854ddb9 30 3 triglyceride triglyceride NN cord-265322-3854ddb9 30 4 and and CC cord-265322-3854ddb9 30 5 lipid lipid NN cord-265322-3854ddb9 30 6 droplet droplet NN cord-265322-3854ddb9 30 7 catabolism catabolism NN cord-265322-3854ddb9 30 8 is be VBZ cord-265322-3854ddb9 30 9 one one CD cord-265322-3854ddb9 30 10 such such JJ cord-265322-3854ddb9 30 11 mechanism mechanism NN cord-265322-3854ddb9 30 12 , , , cord-265322-3854ddb9 30 13 as as IN cord-265322-3854ddb9 30 14 identified identify VBN cord-265322-3854ddb9 30 15 in in IN cord-265322-3854ddb9 30 16 DENV DENV NNP cord-265322-3854ddb9 30 17 infection infection NN cord-265322-3854ddb9 30 18 ( ( -LRB- cord-265322-3854ddb9 30 19 13 13 CD cord-265322-3854ddb9 30 20 ) ) -RRB- cord-265322-3854ddb9 30 21 . . . cord-265322-3854ddb9 31 1 Hijacking hijack VBG cord-265322-3854ddb9 31 2 the the DT cord-265322-3854ddb9 31 3 host host NN cord-265322-3854ddb9 31 4 cells cell NNS cord-265322-3854ddb9 31 5 ' ' POS cord-265322-3854ddb9 31 6 lipid lipid NN cord-265322-3854ddb9 31 7 metabolism metabolism NN cord-265322-3854ddb9 31 8 has have VBZ cord-265322-3854ddb9 31 9 been be VBN cord-265322-3854ddb9 31 10 shown show VBN cord-265322-3854ddb9 31 11 to to TO cord-265322-3854ddb9 31 12 be be VB cord-265322-3854ddb9 31 13 a a DT cord-265322-3854ddb9 31 14 critical critical JJ cord-265322-3854ddb9 31 15 step step NN cord-265322-3854ddb9 31 16 in in IN cord-265322-3854ddb9 31 17 establishing establish VBG cord-265322-3854ddb9 31 18 HCoV-22E HCoV-22E NNP cord-265322-3854ddb9 31 19 and and CC cord-265322-3854ddb9 31 20 MERS MERS NNP cord-265322-3854ddb9 31 21 -coronavirus -coronavirus CD cord-265322-3854ddb9 32 1 latency latency NNP cord-265322-3854ddb9 32 2 ( ( -LRB- cord-265322-3854ddb9 32 3 14 14 CD cord-265322-3854ddb9 32 4 ) ) -RRB- cord-265322-3854ddb9 32 5 . . . cord-265322-3854ddb9 33 1 In in IN cord-265322-3854ddb9 33 2 SARS SARS NNP cord-265322-3854ddb9 33 3 - - HYPH cord-265322-3854ddb9 33 4 CoV CoV NNP cord-265322-3854ddb9 33 5 patients patient NNS cord-265322-3854ddb9 33 6 , , , cord-265322-3854ddb9 33 7 alterations alteration NNS cord-265322-3854ddb9 33 8 in in IN cord-265322-3854ddb9 33 9 lipid lipid NN cord-265322-3854ddb9 33 10 metabolism metabolism NN cord-265322-3854ddb9 33 11 have have VBP cord-265322-3854ddb9 33 12 been be VBN cord-265322-3854ddb9 33 13 detected detect VBN cord-265322-3854ddb9 33 14 as as RB cord-265322-3854ddb9 33 15 far far RB cord-265322-3854ddb9 33 16 as as IN cord-265322-3854ddb9 33 17 12 12 CD cord-265322-3854ddb9 33 18 years year NNS cord-265322-3854ddb9 33 19 after after IN cord-265322-3854ddb9 33 20 the the DT cord-265322-3854ddb9 33 21 initial initial JJ cord-265322-3854ddb9 33 22 infection infection NN cord-265322-3854ddb9 33 23 ( ( -LRB- cord-265322-3854ddb9 33 24 15 15 CD cord-265322-3854ddb9 33 25 ) ) -RRB- cord-265322-3854ddb9 33 26 . . . cord-265322-3854ddb9 34 1 Evidence evidence NN cord-265322-3854ddb9 34 2 on on IN cord-265322-3854ddb9 34 3 COVID-19 COVID-19 NNP cord-265322-3854ddb9 34 4 's 's POS cord-265322-3854ddb9 34 5 interplay interplay NN cord-265322-3854ddb9 34 6 with with IN cord-265322-3854ddb9 34 7 diabetes diabetes NN cord-265322-3854ddb9 34 8 is be VBZ cord-265322-3854ddb9 34 9 only only RB cord-265322-3854ddb9 34 10 recently recently RB cord-265322-3854ddb9 34 11 emerging emerge VBG cord-265322-3854ddb9 34 12 , , , cord-265322-3854ddb9 34 13 and and CC cord-265322-3854ddb9 34 14 can can MD cord-265322-3854ddb9 34 15 currently currently RB cord-265322-3854ddb9 34 16 only only RB cord-265322-3854ddb9 34 17 be be VB cord-265322-3854ddb9 34 18 considered consider VBN cord-265322-3854ddb9 34 19 within within IN cord-265322-3854ddb9 34 20 the the DT cord-265322-3854ddb9 34 21 context context NN cord-265322-3854ddb9 34 22 of of IN cord-265322-3854ddb9 34 23 epidemiological epidemiological JJ cord-265322-3854ddb9 34 24 studies study NNS cord-265322-3854ddb9 34 25 , , , cord-265322-3854ddb9 34 26 determining determine VBG cord-265322-3854ddb9 34 27 diabetes diabetes NN cord-265322-3854ddb9 34 28 mellitus mellitus NN cord-265322-3854ddb9 34 29 ( ( -LRB- cord-265322-3854ddb9 34 30 DM DM NNP cord-265322-3854ddb9 34 31 ) ) -RRB- cord-265322-3854ddb9 34 32 as as IN cord-265322-3854ddb9 34 33 frequent frequent JJ cord-265322-3854ddb9 34 34 comorbidity comorbidity NN cord-265322-3854ddb9 34 35 . . . cord-265322-3854ddb9 35 1 Furthermore furthermore RB cord-265322-3854ddb9 35 2 , , , cord-265322-3854ddb9 35 3 DM DM NNP cord-265322-3854ddb9 35 4 has have VBZ cord-265322-3854ddb9 35 5 recently recently RB cord-265322-3854ddb9 35 6 been be VBN cord-265322-3854ddb9 35 7 characterized characterize VBN cord-265322-3854ddb9 35 8 as as IN cord-265322-3854ddb9 35 9 a a DT cord-265322-3854ddb9 35 10 determinant determinant NN cord-265322-3854ddb9 35 11 of of IN cord-265322-3854ddb9 35 12 more more RBR cord-265322-3854ddb9 35 13 severe severe JJ cord-265322-3854ddb9 35 14 respiratory respiratory JJ cord-265322-3854ddb9 35 15 syndrome syndrome NN cord-265322-3854ddb9 35 16 , , , cord-265322-3854ddb9 35 17 along along IN cord-265322-3854ddb9 35 18 with with IN cord-265322-3854ddb9 35 19 other other JJ cord-265322-3854ddb9 35 20 comorbidities comorbiditie NNS cord-265322-3854ddb9 35 21 ( ( -LRB- cord-265322-3854ddb9 35 22 16 16 CD cord-265322-3854ddb9 35 23 ) ) -RRB- cord-265322-3854ddb9 35 24 . . . cord-265322-3854ddb9 36 1 Aside aside RB cord-265322-3854ddb9 36 2 from from IN cord-265322-3854ddb9 36 3 DM DM NNP cord-265322-3854ddb9 36 4 , , , cord-265322-3854ddb9 36 5 novel novel JJ cord-265322-3854ddb9 36 6 hyperglycemia hyperglycemia NN cord-265322-3854ddb9 36 7 was be VBD cord-265322-3854ddb9 36 8 recently recently RB cord-265322-3854ddb9 36 9 associated associate VBN cord-265322-3854ddb9 36 10 with with IN cord-265322-3854ddb9 36 11 an an DT cord-265322-3854ddb9 36 12 increased increase VBN cord-265322-3854ddb9 36 13 with with IN cord-265322-3854ddb9 36 14 worse bad JJR cord-265322-3854ddb9 36 15 outcomes outcome NNS cord-265322-3854ddb9 36 16 in in IN cord-265322-3854ddb9 36 17 COVID-19 covid-19 JJ cord-265322-3854ddb9 36 18 patients patient NNS cord-265322-3854ddb9 36 19 , , , cord-265322-3854ddb9 36 20 however however RB cord-265322-3854ddb9 36 21 this this DT cord-265322-3854ddb9 36 22 association association NN cord-265322-3854ddb9 36 23 was be VBD cord-265322-3854ddb9 36 24 not not RB cord-265322-3854ddb9 36 25 independent independent JJ cord-265322-3854ddb9 36 26 of of IN cord-265322-3854ddb9 36 27 other other JJ cord-265322-3854ddb9 36 28 predictors predictor NNS cord-265322-3854ddb9 36 29 in in IN cord-265322-3854ddb9 36 30 the the DT cord-265322-3854ddb9 36 31 multivariate multivariate JJ cord-265322-3854ddb9 36 32 model model NN cord-265322-3854ddb9 36 33 ( ( -LRB- cord-265322-3854ddb9 36 34 17 17 CD cord-265322-3854ddb9 36 35 ) ) -RRB- cord-265322-3854ddb9 36 36 . . . cord-265322-3854ddb9 37 1 Epidemiological epidemiological JJ cord-265322-3854ddb9 37 2 associations association NNS cord-265322-3854ddb9 37 3 between between IN cord-265322-3854ddb9 37 4 COVID-19 covid-19 CD cord-265322-3854ddb9 37 5 and and CC cord-265322-3854ddb9 37 6 lipid lipid NN cord-265322-3854ddb9 37 7 metabolism metabolism NN cord-265322-3854ddb9 37 8 are be VBP cord-265322-3854ddb9 37 9 currently currently RB cord-265322-3854ddb9 37 10 not not RB cord-265322-3854ddb9 37 11 possible possible JJ cord-265322-3854ddb9 37 12 , , , cord-265322-3854ddb9 37 13 since since IN cord-265322-3854ddb9 37 14 even even RB cord-265322-3854ddb9 37 15 large large JJ cord-265322-3854ddb9 37 16 scale scale NN cord-265322-3854ddb9 37 17 cohorts cohort NNS cord-265322-3854ddb9 37 18 do do VBP cord-265322-3854ddb9 37 19 not not RB cord-265322-3854ddb9 37 20 report report VB cord-265322-3854ddb9 37 21 on on IN cord-265322-3854ddb9 37 22 relevant relevant JJ cord-265322-3854ddb9 37 23 measurements measurement NNS cord-265322-3854ddb9 37 24 ( ( -LRB- cord-265322-3854ddb9 37 25 18 18 CD cord-265322-3854ddb9 37 26 ) ) -RRB- cord-265322-3854ddb9 37 27 . . . cord-265322-3854ddb9 38 1 On on IN cord-265322-3854ddb9 38 2 the the DT cord-265322-3854ddb9 38 3 experimental experimental JJ cord-265322-3854ddb9 38 4 level level NN cord-265322-3854ddb9 38 5 , , , cord-265322-3854ddb9 38 6 lipid lipid NN cord-265322-3854ddb9 38 7 metabolism metabolism NN cord-265322-3854ddb9 38 8 on on IN cord-265322-3854ddb9 38 9 the the DT cord-265322-3854ddb9 38 10 cellular cellular JJ cord-265322-3854ddb9 38 11 level level NN cord-265322-3854ddb9 38 12 has have VBZ cord-265322-3854ddb9 38 13 been be VBN cord-265322-3854ddb9 38 14 proposed propose VBN cord-265322-3854ddb9 38 15 as as IN cord-265322-3854ddb9 38 16 a a DT cord-265322-3854ddb9 38 17 treatment treatment NN cord-265322-3854ddb9 38 18 target target NN cord-265322-3854ddb9 38 19 for for IN cord-265322-3854ddb9 38 20 COVID-19 COVID-19 NNP cord-265322-3854ddb9 38 21 ; ; : cord-265322-3854ddb9 38 22 specifically specifically RB cord-265322-3854ddb9 38 23 , , , cord-265322-3854ddb9 38 24 both both DT cord-265322-3854ddb9 38 25 interactions interaction NNS cord-265322-3854ddb9 38 26 between between IN cord-265322-3854ddb9 38 27 SARS SARS NNP cord-265322-3854ddb9 38 28 - - HYPH cord-265322-3854ddb9 38 29 CoV CoV NNP cord-265322-3854ddb9 38 30 's 's POS cord-265322-3854ddb9 38 31 spike spike NN cord-265322-3854ddb9 38 32 protein protein NN cord-265322-3854ddb9 38 33 with with IN cord-265322-3854ddb9 38 34 lipid lipid JJ cord-265322-3854ddb9 38 35 rich rich JJ cord-265322-3854ddb9 38 36 membrane membrane NN cord-265322-3854ddb9 38 37 compartments compartment NNS cord-265322-3854ddb9 38 38 , , , cord-265322-3854ddb9 38 39 as as RB cord-265322-3854ddb9 38 40 well well RB cord-265322-3854ddb9 38 41 as as IN cord-265322-3854ddb9 38 42 the the DT cord-265322-3854ddb9 38 43 epigenetic epigenetic JJ cord-265322-3854ddb9 38 44 modulations modulation NNS cord-265322-3854ddb9 38 45 in in IN cord-265322-3854ddb9 38 46 lipid lipid NN cord-265322-3854ddb9 38 47 metabolism metabolism NN cord-265322-3854ddb9 38 48 were be VBD cord-265322-3854ddb9 38 49 considered consider VBN cord-265322-3854ddb9 38 50 as as IN cord-265322-3854ddb9 38 51 the the DT cord-265322-3854ddb9 38 52 end end NN cord-265322-3854ddb9 38 53 - - HYPH cord-265322-3854ddb9 38 54 point point NN cord-265322-3854ddb9 38 55 targets target NNS cord-265322-3854ddb9 38 56 for for IN cord-265322-3854ddb9 38 57 the the DT cord-265322-3854ddb9 38 58 development development NN cord-265322-3854ddb9 38 59 of of IN cord-265322-3854ddb9 38 60 small small JJ cord-265322-3854ddb9 38 61 molecules molecule NNS cord-265322-3854ddb9 38 62 , , , cord-265322-3854ddb9 38 63 aiming aim VBG cord-265322-3854ddb9 38 64 to to TO cord-265322-3854ddb9 38 65 prevent prevent VB cord-265322-3854ddb9 38 66 SARS SARS NNP cord-265322-3854ddb9 38 67 - - HYPH cord-265322-3854ddb9 38 68 CoV-2 CoV-2 NNP cord-265322-3854ddb9 38 69 infection infection NN cord-265322-3854ddb9 38 70 ( ( -LRB- cord-265322-3854ddb9 38 71 19 19 CD cord-265322-3854ddb9 38 72 ) ) -RRB- cord-265322-3854ddb9 38 73 . . . cord-265322-3854ddb9 39 1 Barring bar VBG cord-265322-3854ddb9 39 2 actual actual JJ cord-265322-3854ddb9 39 3 proteomics proteomic NNS cord-265322-3854ddb9 39 4 SARS SARS NNP cord-265322-3854ddb9 39 5 - - HYPH cord-265322-3854ddb9 39 6 CoV-2 CoV-2 NNP cord-265322-3854ddb9 39 7 , , , cord-265322-3854ddb9 39 8 SARS SARS NNP cord-265322-3854ddb9 39 9 - - HYPH cord-265322-3854ddb9 39 10 CoV CoV NNP cord-265322-3854ddb9 39 11 based base VBN cord-265322-3854ddb9 39 12 in in IN cord-265322-3854ddb9 39 13 silico silico NN cord-265322-3854ddb9 39 14 analyses analysis NNS cord-265322-3854ddb9 39 15 of of IN cord-265322-3854ddb9 39 16 the the DT cord-265322-3854ddb9 39 17 SARS SARS NNP cord-265322-3854ddb9 39 18 - - HYPH cord-265322-3854ddb9 39 19 CoV CoV NNP cord-265322-3854ddb9 39 20 -Human -Human . cord-265322-3854ddb9 39 21 interaction interaction NN cord-265322-3854ddb9 39 22 partially partially RB cord-265322-3854ddb9 39 23 support support VBP cord-265322-3854ddb9 39 24 the the DT cord-265322-3854ddb9 39 25 hypothesis hypothesis NN cord-265322-3854ddb9 39 26 of of IN cord-265322-3854ddb9 39 27 Fang Fang NNP cord-265322-3854ddb9 39 28 and and CC cord-265322-3854ddb9 39 29 colleagues colleague NNS cord-265322-3854ddb9 39 30 , , , cord-265322-3854ddb9 39 31 insofar insofar RB cord-265322-3854ddb9 39 32 as as IN cord-265322-3854ddb9 39 33 to to TO cord-265322-3854ddb9 39 34 warrant warrant VB cord-265322-3854ddb9 39 35 further further JJ cord-265322-3854ddb9 39 36 scrutiny scrutiny NN cord-265322-3854ddb9 39 37 on on IN cord-265322-3854ddb9 39 38 COVID19 COVID19 NNP cord-265322-3854ddb9 39 39 patient patient NN cord-265322-3854ddb9 39 40 's 's POS cord-265322-3854ddb9 39 41 metabolic metabolic JJ cord-265322-3854ddb9 39 42 states state NNS cord-265322-3854ddb9 39 43 and and CC cord-265322-3854ddb9 39 44 concomitant concomitant JJ cord-265322-3854ddb9 39 45 medication medication NN cord-265322-3854ddb9 39 46 . . . cord-265322-3854ddb9 40 1 While while IN cord-265322-3854ddb9 40 2 the the DT cord-265322-3854ddb9 40 3 approach approach NN cord-265322-3854ddb9 40 4 presented present VBN cord-265322-3854ddb9 40 5 here here RB cord-265322-3854ddb9 40 6 is be VBZ cord-265322-3854ddb9 40 7 inherently inherently RB cord-265322-3854ddb9 40 8 limited limited JJ cord-265322-3854ddb9 40 9 due due IN cord-265322-3854ddb9 40 10 to to IN cord-265322-3854ddb9 40 11 setting set VBG cord-265322-3854ddb9 40 12 its -PRON- PRP$ cord-265322-3854ddb9 40 13 basis basis NN cord-265322-3854ddb9 40 14 on on IN cord-265322-3854ddb9 40 15 the the DT cord-265322-3854ddb9 40 16 SARS SARS NNP cord-265322-3854ddb9 40 17 - - HYPH cord-265322-3854ddb9 40 18 CoV CoV NNP cord-265322-3854ddb9 40 19 proteomic proteomic JJ cord-265322-3854ddb9 40 20 interactions interaction NNS cord-265322-3854ddb9 40 21 , , , cord-265322-3854ddb9 40 22 it -PRON- PRP cord-265322-3854ddb9 40 23 nevertheless nevertheless RB cord-265322-3854ddb9 40 24 presents present VBZ cord-265322-3854ddb9 40 25 in in IN cord-265322-3854ddb9 40 26 silico silico NN cord-265322-3854ddb9 40 27 and and CC cord-265322-3854ddb9 40 28 literature literature NN cord-265322-3854ddb9 40 29 evidence evidence NN cord-265322-3854ddb9 40 30 supporting support VBG cord-265322-3854ddb9 40 31 SARS SARS NNP cord-265322-3854ddb9 40 32 - - HYPH cord-265322-3854ddb9 40 33 CoV-2 CoV-2 NNP cord-265322-3854ddb9 40 34 potential potential NN cord-265322-3854ddb9 40 35 to to TO cord-265322-3854ddb9 40 36 affect affect VB cord-265322-3854ddb9 40 37 human human JJ cord-265322-3854ddb9 40 38 metabolism metabolism NN cord-265322-3854ddb9 40 39 . . . cord-265322-3854ddb9 41 1 Furthermore furthermore RB cord-265322-3854ddb9 41 2 , , , cord-265322-3854ddb9 41 3 as as IN cord-265322-3854ddb9 41 4 genes gene NNS cord-265322-3854ddb9 41 5 affected affect VBN cord-265322-3854ddb9 41 6 by by IN cord-265322-3854ddb9 41 7 SARS SARS NNP cord-265322-3854ddb9 41 8 - - HYPH cord-265322-3854ddb9 41 9 CoV CoV NNP cord-265322-3854ddb9 41 10 infection infection NN cord-265322-3854ddb9 41 11 are be VBP cord-265322-3854ddb9 41 12 significantly significantly RB cord-265322-3854ddb9 41 13 enriched enrich VBN cord-265322-3854ddb9 41 14 for for IN cord-265322-3854ddb9 41 15 other other JJ cord-265322-3854ddb9 41 16 infections infection NNS cord-265322-3854ddb9 41 17 , , , cord-265322-3854ddb9 41 18 they -PRON- PRP cord-265322-3854ddb9 41 19 may may MD cord-265322-3854ddb9 41 20 represent represent VB cord-265322-3854ddb9 41 21 a a DT cord-265322-3854ddb9 41 22 common common JJ cord-265322-3854ddb9 41 23 interface interface NN cord-265322-3854ddb9 41 24 , , , cord-265322-3854ddb9 41 25 targeted target VBN cord-265322-3854ddb9 41 26 by by IN cord-265322-3854ddb9 41 27 viruses virus NNS cord-265322-3854ddb9 41 28 . . . cord-265322-3854ddb9 42 1 Future future JJ cord-265322-3854ddb9 42 2 studies study NNS cord-265322-3854ddb9 42 3 should should MD cord-265322-3854ddb9 42 4 determine determine VB cord-265322-3854ddb9 42 5 SARS SARS NNP cord-265322-3854ddb9 42 6 - - HYPH cord-265322-3854ddb9 42 7 CoV-2 CoV-2 NNP cord-265322-3854ddb9 42 8 interaction interaction NN cord-265322-3854ddb9 42 9 and and CC cord-265322-3854ddb9 42 10 effect effect NN cord-265322-3854ddb9 42 11 on on IN cord-265322-3854ddb9 42 12 the the DT cord-265322-3854ddb9 42 13 human human JJ cord-265322-3854ddb9 42 14 transcriptome transcriptome NN cord-265322-3854ddb9 42 15 , , , cord-265322-3854ddb9 42 16 further further RB cord-265322-3854ddb9 42 17 identifying identify VBG cord-265322-3854ddb9 42 18 drug drug NN cord-265322-3854ddb9 42 19 targets target NNS cord-265322-3854ddb9 42 20 using use VBG cord-265322-3854ddb9 42 21 pharmacogenomic pharmacogenomic JJ cord-265322-3854ddb9 42 22 enrichment enrichment NN cord-265322-3854ddb9 42 23 analyses analysis NNS cord-265322-3854ddb9 42 24 . . . cord-265322-3854ddb9 43 1 The the DT cord-265322-3854ddb9 43 2 author author NN cord-265322-3854ddb9 43 3 confirms confirm VBZ cord-265322-3854ddb9 43 4 that that IN cord-265322-3854ddb9 43 5 there there EX cord-265322-3854ddb9 43 6 are be VBP cord-265322-3854ddb9 43 7 no no DT cord-265322-3854ddb9 43 8 known know VBN cord-265322-3854ddb9 43 9 conflicts conflict NNS cord-265322-3854ddb9 43 10 of of IN cord-265322-3854ddb9 43 11 interest interest NN cord-265322-3854ddb9 43 12 associated associate VBN cord-265322-3854ddb9 43 13 with with IN cord-265322-3854ddb9 43 14 this this DT cord-265322-3854ddb9 43 15 manuscript manuscript NN cord-265322-3854ddb9 43 16 and and CC cord-265322-3854ddb9 43 17 there there EX cord-265322-3854ddb9 43 18 has have VBZ cord-265322-3854ddb9 43 19 been be VBN cord-265322-3854ddb9 43 20 no no DT cord-265322-3854ddb9 43 21 financial financial JJ cord-265322-3854ddb9 43 22 support support NN cord-265322-3854ddb9 43 23 for for IN cord-265322-3854ddb9 43 24 this this DT cord-265322-3854ddb9 43 25 work work NN cord-265322-3854ddb9 43 26 that that WDT cord-265322-3854ddb9 43 27 could could MD cord-265322-3854ddb9 43 28 have have VB cord-265322-3854ddb9 43 29 influenced influence VBN cord-265322-3854ddb9 43 30 its -PRON- PRP$ cord-265322-3854ddb9 43 31 outcome outcome NN cord-265322-3854ddb9 43 32 . . . cord-265322-3854ddb9 44 1 SARS SARS NNP cord-265322-3854ddb9 44 2 - - HYPH cord-265322-3854ddb9 44 3 CoV-2 CoV-2 NNP cord-265322-3854ddb9 44 4 and and CC cord-265322-3854ddb9 44 5 COVID-19 COVID-19 NNP cord-265322-3854ddb9 45 1 : : : cord-265322-3854ddb9 45 2 The the DT cord-265322-3854ddb9 45 3 most most RBS cord-265322-3854ddb9 45 4 important important JJ cord-265322-3854ddb9 45 5 research research NN cord-265322-3854ddb9 45 6 questions question NNS cord-265322-3854ddb9 45 7 Genomic genomic JJ cord-265322-3854ddb9 45 8 characterisation characterisation NN cord-265322-3854ddb9 45 9 and and CC cord-265322-3854ddb9 45 10 epidemiology epidemiology NN cord-265322-3854ddb9 45 11 of of IN cord-265322-3854ddb9 45 12 2019 2019 CD cord-265322-3854ddb9 45 13 novel novel JJ cord-265322-3854ddb9 45 14 coronavirus coronavirus NN cord-265322-3854ddb9 45 15 : : : cord-265322-3854ddb9 45 16 implications implication NNS cord-265322-3854ddb9 45 17 for for IN cord-265322-3854ddb9 45 18 virus virus NN cord-265322-3854ddb9 45 19 origins origin NNS cord-265322-3854ddb9 45 20 and and CC cord-265322-3854ddb9 45 21 receptor receptor NN cord-265322-3854ddb9 46 1 binding bind VBG cord-265322-3854ddb9 46 2 SARS SARS NNP cord-265322-3854ddb9 46 3 - - HYPH cord-265322-3854ddb9 46 4 CoV-2 CoV-2 NNP cord-265322-3854ddb9 46 5 Cell Cell NNP cord-265322-3854ddb9 46 6 Entry entry NN cord-265322-3854ddb9 46 7 Depends depend VBZ cord-265322-3854ddb9 46 8 on on IN cord-265322-3854ddb9 46 9 ACE2 ACE2 NNP cord-265322-3854ddb9 46 10 and and CC cord-265322-3854ddb9 46 11 TMPRSS2 TMPRSS2 NNP cord-265322-3854ddb9 46 12 and and CC cord-265322-3854ddb9 46 13 Is be VBZ cord-265322-3854ddb9 46 14 Blocked block VBN cord-265322-3854ddb9 46 15 by by IN cord-265322-3854ddb9 46 16 a a DT cord-265322-3854ddb9 46 17 Clinically clinically RB cord-265322-3854ddb9 46 18 Proven prove VBN cord-265322-3854ddb9 46 19 Protease protease NN cord-265322-3854ddb9 46 20 Inhibitor Inhibitor NNP cord-265322-3854ddb9 46 21 Differences difference NNS cord-265322-3854ddb9 46 22 and and CC cord-265322-3854ddb9 46 23 similarities similarity NNS cord-265322-3854ddb9 46 24 between between IN cord-265322-3854ddb9 46 25 Severe severe JJ cord-265322-3854ddb9 46 26 Acute acute JJ cord-265322-3854ddb9 46 27 Respiratory Respiratory NNP cord-265322-3854ddb9 46 28 Syndrome Syndrome NNP cord-265322-3854ddb9 46 29 ( ( -LRB- cord-265322-3854ddb9 46 30 SARS)-CoronaVirus SARS)-CoronaVirus NNP cord-265322-3854ddb9 46 31 ( ( -LRB- cord-265322-3854ddb9 46 32 CoV CoV NNP cord-265322-3854ddb9 46 33 ) ) -RRB- cord-265322-3854ddb9 46 34 and and CC cord-265322-3854ddb9 46 35 SARS SARS NNP cord-265322-3854ddb9 46 36 - - HYPH cord-265322-3854ddb9 46 37 CoV-2 CoV-2 NNP cord-265322-3854ddb9 46 38 . . . cord-265322-3854ddb9 47 1 Would Would MD cord-265322-3854ddb9 47 2 a a DT cord-265322-3854ddb9 47 3 rose rose NN cord-265322-3854ddb9 47 4 by by IN cord-265322-3854ddb9 47 5 another another DT cord-265322-3854ddb9 47 6 name name NN cord-265322-3854ddb9 47 7 smell smell NN cord-265322-3854ddb9 47 8 as as IN cord-265322-3854ddb9 47 9 sweet sweet JJ cord-265322-3854ddb9 47 10 ? ? . cord-265322-3854ddb9 48 1 Receptor receptor NN cord-265322-3854ddb9 48 2 recognition recognition NN cord-265322-3854ddb9 48 3 by by IN cord-265322-3854ddb9 48 4 novel novel JJ cord-265322-3854ddb9 48 5 coronavirus coronavirus NN cord-265322-3854ddb9 48 6 from from IN cord-265322-3854ddb9 48 7 Wuhan Wuhan NNP cord-265322-3854ddb9 48 8 : : : cord-265322-3854ddb9 49 1 An an DT cord-265322-3854ddb9 49 2 analysis analysis NN cord-265322-3854ddb9 49 3 based base VBN cord-265322-3854ddb9 49 4 on on IN cord-265322-3854ddb9 49 5 decade decade NN cord-265322-3854ddb9 49 6 - - HYPH cord-265322-3854ddb9 49 7 long long JJ cord-265322-3854ddb9 49 8 structural structural JJ cord-265322-3854ddb9 49 9 studies study NNS cord-265322-3854ddb9 49 10 of of IN cord-265322-3854ddb9 49 11 SARS SARS NNP cord-265322-3854ddb9 49 12 Clinical Clinical NNP cord-265322-3854ddb9 49 13 course course NN cord-265322-3854ddb9 49 14 and and CC cord-265322-3854ddb9 49 15 outcomes outcome NNS cord-265322-3854ddb9 49 16 of of IN cord-265322-3854ddb9 49 17 critically critically RB cord-265322-3854ddb9 49 18 ill ill JJ cord-265322-3854ddb9 49 19 patients patient NNS cord-265322-3854ddb9 49 20 with with IN cord-265322-3854ddb9 49 21 SARS SARS NNP cord-265322-3854ddb9 49 22 - - HYPH cord-265322-3854ddb9 49 23 CoV-2 CoV-2 NNP cord-265322-3854ddb9 49 24 pneumonia pneumonia NN cord-265322-3854ddb9 49 25 in in IN cord-265322-3854ddb9 49 26 Wuhan Wuhan NNP cord-265322-3854ddb9 49 27 , , , cord-265322-3854ddb9 49 28 China China NNP cord-265322-3854ddb9 49 29 : : : cord-265322-3854ddb9 50 1 a a DT cord-265322-3854ddb9 50 2 single single RB cord-265322-3854ddb9 50 3 - - HYPH cord-265322-3854ddb9 50 4 centered centered JJ cord-265322-3854ddb9 50 5 , , , cord-265322-3854ddb9 50 6 retrospective retrospective JJ cord-265322-3854ddb9 50 7 , , , cord-265322-3854ddb9 50 8 observational observational JJ cord-265322-3854ddb9 50 9 study study NN cord-265322-3854ddb9 50 10 Are be VBP cord-265322-3854ddb9 50 11 patients patient NNS cord-265322-3854ddb9 50 12 with with IN cord-265322-3854ddb9 50 13 hypertension hypertension NN cord-265322-3854ddb9 50 14 and and CC cord-265322-3854ddb9 50 15 diabetes diabetes NN cord-265322-3854ddb9 50 16 mellitus mellitus NN cord-265322-3854ddb9 50 17 at at IN cord-265322-3854ddb9 50 18 increased increase VBN cord-265322-3854ddb9 50 19 risk risk NN cord-265322-3854ddb9 50 20 for for IN cord-265322-3854ddb9 50 21 COVID-19 COVID-19 NNP cord-265322-3854ddb9 50 22 infection infection NN cord-265322-3854ddb9 50 23 STRING string NN cord-265322-3854ddb9 50 24 v11 v11 VBZ cord-265322-3854ddb9 50 25 : : : cord-265322-3854ddb9 51 1 protein protein NN cord-265322-3854ddb9 51 2 - - HYPH cord-265322-3854ddb9 51 3 protein protein NN cord-265322-3854ddb9 51 4 association association NN cord-265322-3854ddb9 51 5 networks network NNS cord-265322-3854ddb9 51 6 with with IN cord-265322-3854ddb9 51 7 increased increase VBN cord-265322-3854ddb9 51 8 coverage coverage NN cord-265322-3854ddb9 51 9 , , , cord-265322-3854ddb9 51 10 supporting support VBG cord-265322-3854ddb9 51 11 functional functional JJ cord-265322-3854ddb9 51 12 discovery discovery NN cord-265322-3854ddb9 51 13 in in IN cord-265322-3854ddb9 51 14 genome genome NN cord-265322-3854ddb9 51 15 - - HYPH cord-265322-3854ddb9 51 16 wide wide JJ cord-265322-3854ddb9 51 17 experimental experimental JJ cord-265322-3854ddb9 51 18 datasets dataset NNS cord-265322-3854ddb9 51 19 Plasma plasma NN cord-265322-3854ddb9 51 20 glucose glucose NN cord-265322-3854ddb9 51 21 levels level NNS cord-265322-3854ddb9 51 22 and and CC cord-265322-3854ddb9 51 23 diabetes diabetes NN cord-265322-3854ddb9 51 24 are be VBP cord-265322-3854ddb9 51 25 independent independent JJ cord-265322-3854ddb9 51 26 predictors predictor NNS cord-265322-3854ddb9 51 27 for for IN cord-265322-3854ddb9 51 28 mortality mortality NN cord-265322-3854ddb9 51 29 and and CC cord-265322-3854ddb9 51 30 morbidity morbidity NN cord-265322-3854ddb9 51 31 in in IN cord-265322-3854ddb9 51 32 patients patient NNS cord-265322-3854ddb9 51 33 with with IN cord-265322-3854ddb9 51 34 SARS SARS NNP cord-265322-3854ddb9 51 35 Binding Binding NNP cord-265322-3854ddb9 51 36 of of IN cord-265322-3854ddb9 51 37 SARS SARS NNP cord-265322-3854ddb9 51 38 coronavirus coronavirus NN cord-265322-3854ddb9 51 39 to to IN cord-265322-3854ddb9 51 40 its -PRON- PRP$ cord-265322-3854ddb9 51 41 receptor receptor NN cord-265322-3854ddb9 51 42 damages damage NNS cord-265322-3854ddb9 51 43 islets islet NNS cord-265322-3854ddb9 51 44 and and CC cord-265322-3854ddb9 51 45 causes cause VBZ cord-265322-3854ddb9 51 46 acute acute JJ cord-265322-3854ddb9 51 47 diabetes diabetes NN cord-265322-3854ddb9 51 48 Activation activation NN cord-265322-3854ddb9 51 49 of of IN cord-265322-3854ddb9 51 50 the the DT cord-265322-3854ddb9 51 51 ACE2 ACE2 NNP cord-265322-3854ddb9 51 52 / / SYM cord-265322-3854ddb9 51 53 angiotensin-(1 angiotensin-(1 CD cord-265322-3854ddb9 51 54 - - HYPH cord-265322-3854ddb9 51 55 7)/Mas 7)/mas CD cord-265322-3854ddb9 51 56 receptor receptor NN cord-265322-3854ddb9 51 57 axis axis NN cord-265322-3854ddb9 51 58 enhances enhance VBZ cord-265322-3854ddb9 51 59 the the DT cord-265322-3854ddb9 51 60 reparative reparative JJ cord-265322-3854ddb9 51 61 function function NN cord-265322-3854ddb9 51 62 of of IN cord-265322-3854ddb9 51 63 dysfunctional dysfunctional JJ cord-265322-3854ddb9 51 64 diabetic diabetic JJ cord-265322-3854ddb9 51 65 endothelial endothelial JJ cord-265322-3854ddb9 51 66 progenitors progenitor NNS cord-265322-3854ddb9 51 67 Host host NN cord-265322-3854ddb9 51 68 Lipids lipid NNS cord-265322-3854ddb9 51 69 in in IN cord-265322-3854ddb9 51 70 Positive Positive NNP cord-265322-3854ddb9 51 71 - - HYPH cord-265322-3854ddb9 51 72 Strand Strand NNP cord-265322-3854ddb9 51 73 RNA RNA NNP cord-265322-3854ddb9 51 74 Virus virus NN cord-265322-3854ddb9 51 75 Genome Genome NNP cord-265322-3854ddb9 51 76 Replication Replication NNP cord-265322-3854ddb9 51 77 Dengue Dengue NNP cord-265322-3854ddb9 51 78 virus virus NN cord-265322-3854ddb9 51 79 - - HYPH cord-265322-3854ddb9 51 80 induced induce VBN cord-265322-3854ddb9 51 81 autophagy autophagy NN cord-265322-3854ddb9 51 82 regulates regulate VBZ cord-265322-3854ddb9 51 83 lipid lipid NN cord-265322-3854ddb9 51 84 metabolism metabolism NN cord-265322-3854ddb9 51 85 Modulation modulation NN cord-265322-3854ddb9 51 86 of of IN cord-265322-3854ddb9 51 87 Lipid Lipid NNP cord-265322-3854ddb9 51 88 Droplet Droplet NNP cord-265322-3854ddb9 51 89 Metabolism Metabolism NNP cord-265322-3854ddb9 51 90 - - HYPH cord-265322-3854ddb9 51 91 A A NNP cord-265322-3854ddb9 51 92 Potential Potential NNP cord-265322-3854ddb9 51 93 Target Target NNP cord-265322-3854ddb9 51 94 for for IN cord-265322-3854ddb9 51 95 Therapeutic Therapeutic NNP cord-265322-3854ddb9 51 96 Intervention Intervention NNP cord-265322-3854ddb9 51 97 in in IN cord-265322-3854ddb9 51 98 Infections infection NNS cord-265322-3854ddb9 52 1 Altered alter VBN cord-265322-3854ddb9 52 2 Lipid Lipid NNP cord-265322-3854ddb9 52 3 Metabolism metabolism NN cord-265322-3854ddb9 52 4 in in IN cord-265322-3854ddb9 52 5 Recovered recovered JJ cord-265322-3854ddb9 52 6 SARS SARS NNP cord-265322-3854ddb9 52 7 Patients patient NNS cord-265322-3854ddb9 53 1 Twelve twelve CD cord-265322-3854ddb9 53 2 Years year NNS cord-265322-3854ddb9 53 3 after after IN cord-265322-3854ddb9 53 4 Risk risk NN cord-265322-3854ddb9 53 5 Factors factor NNS cord-265322-3854ddb9 53 6 Associated associate VBN cord-265322-3854ddb9 53 7 With with IN cord-265322-3854ddb9 53 8 Acute acute JJ cord-265322-3854ddb9 53 9 Respiratory respiratory JJ cord-265322-3854ddb9 53 10 Distress Distress NNP cord-265322-3854ddb9 53 11 Syndrome Syndrome NNP cord-265322-3854ddb9 53 12 and and CC cord-265322-3854ddb9 53 13 Death death NN cord-265322-3854ddb9 53 14 in in IN cord-265322-3854ddb9 53 15 Patients Patients NNP cord-265322-3854ddb9 53 16 With with IN cord-265322-3854ddb9 53 17 Coronavirus Coronavirus NNP cord-265322-3854ddb9 53 18 Disease Disease NNP cord-265322-3854ddb9 53 19 Epidemiological Epidemiological NNP cord-265322-3854ddb9 53 20 , , , cord-265322-3854ddb9 53 21 clinical clinical JJ cord-265322-3854ddb9 53 22 characteristics characteristic NNS cord-265322-3854ddb9 53 23 of of IN cord-265322-3854ddb9 53 24 cases case NNS cord-265322-3854ddb9 53 25 of of IN cord-265322-3854ddb9 53 26 SARS SARS NNP cord-265322-3854ddb9 53 27 - - HYPH cord-265322-3854ddb9 53 28 CoV-2 CoV-2 NNP cord-265322-3854ddb9 53 29 infection infection NN cord-265322-3854ddb9 53 30 with with IN cord-265322-3854ddb9 53 31 abnormal abnormal JJ cord-265322-3854ddb9 53 32 imaging imaging NN cord-265322-3854ddb9 53 33 findings finding NNS cord-265322-3854ddb9 53 34 Prevalence prevalence NN cord-265322-3854ddb9 53 35 of of IN cord-265322-3854ddb9 53 36 comorbidities comorbiditie NNS cord-265322-3854ddb9 53 37 in in IN cord-265322-3854ddb9 53 38 the the DT cord-265322-3854ddb9 53 39 novel novel JJ cord-265322-3854ddb9 53 40 Wuhan Wuhan NNP cord-265322-3854ddb9 53 41 coronavirus coronavirus NN cord-265322-3854ddb9 53 42 ( ( -LRB- cord-265322-3854ddb9 53 43 COVID-19 covid-19 VB cord-265322-3854ddb9 53 44 ) ) -RRB- cord-265322-3854ddb9 53 45 infection infection NN cord-265322-3854ddb9 53 46 : : : cord-265322-3854ddb9 53 47 a a DT cord-265322-3854ddb9 53 48 systematic systematic JJ cord-265322-3854ddb9 53 49 review review NN cord-265322-3854ddb9 53 50 and and CC cord-265322-3854ddb9 53 51 meta meta NNP cord-265322-3854ddb9 53 52 - - HYPH cord-265322-3854ddb9 53 53 analysis analysis NN cord-265322-3854ddb9 53 54 Natural natural JJ cord-265322-3854ddb9 53 55 small small JJ cord-265322-3854ddb9 53 56 molecules molecule NNS cord-265322-3854ddb9 53 57 as as IN cord-265322-3854ddb9 53 58 inhibitors inhibitor NNS cord-265322-3854ddb9 53 59 of of IN cord-265322-3854ddb9 53 60 coronavirus coronavirus NN cord-265322-3854ddb9 53 61 lipid lipid NN cord-265322-3854ddb9 53 62 - - HYPH cord-265322-3854ddb9 53 63 dependent dependent JJ cord-265322-3854ddb9 53 64 attachment attachment NN cord-265322-3854ddb9 53 65 to to TO cord-265322-3854ddb9 53 66 host host VB cord-265322-3854ddb9 53 67 cells cell NNS cord-265322-3854ddb9 53 68 : : : cord-265322-3854ddb9 53 69 a a DT cord-265322-3854ddb9 53 70 possible possible JJ cord-265322-3854ddb9 53 71 strategy strategy NN cord-265322-3854ddb9 53 72 for for IN cord-265322-3854ddb9 53 73 reducing reduce VBG cord-265322-3854ddb9 53 74 SARS SARS NNP cord-265322-3854ddb9 53 75 - - HYPH cord-265322-3854ddb9 53 76 COV-2 COV-2 NNP cord-265322-3854ddb9 53 77 infectivity infectivity NN cord-265322-3854ddb9 53 78 ? ? . cord-265322-3854ddb9 54 1 The the DT cord-265322-3854ddb9 54 2 author author NN cord-265322-3854ddb9 54 3 confirms confirm VBZ cord-265322-3854ddb9 54 4 that that IN cord-265322-3854ddb9 54 5 there there EX cord-265322-3854ddb9 54 6 are be VBP cord-265322-3854ddb9 54 7 no no DT cord-265322-3854ddb9 54 8 known know VBN cord-265322-3854ddb9 54 9 conflicts conflict NNS cord-265322-3854ddb9 54 10 of of IN cord-265322-3854ddb9 54 11 interest interest NN cord-265322-3854ddb9 54 12 associated associate VBN cord-265322-3854ddb9 54 13 with with IN cord-265322-3854ddb9 54 14 this this DT cord-265322-3854ddb9 54 15 manuscript manuscript NN cord-265322-3854ddb9 54 16 and and CC cord-265322-3854ddb9 54 17 there there EX cord-265322-3854ddb9 54 18 has have VBZ cord-265322-3854ddb9 54 19 been be VBN cord-265322-3854ddb9 54 20 no no DT cord-265322-3854ddb9 54 21 financial financial JJ cord-265322-3854ddb9 54 22 support support NN cord-265322-3854ddb9 54 23 for for IN cord-265322-3854ddb9 54 24 this this DT cord-265322-3854ddb9 54 25 work work NN cord-265322-3854ddb9 54 26 that that WDT cord-265322-3854ddb9 54 27 could could MD cord-265322-3854ddb9 54 28 have have VB cord-265322-3854ddb9 54 29 influenced influence VBN cord-265322-3854ddb9 54 30 its -PRON- PRP$ cord-265322-3854ddb9 54 31 outcome outcome NN cord-265322-3854ddb9 54 32 . . . cord-265322-3854ddb9 55 1 George George NNP cord-265322-3854ddb9 55 2 Vavougios Vavougios NNP cord-265322-3854ddb9 55 3 MD MD NNP cord-265322-3854ddb9 55 4 , , , cord-265322-3854ddb9 55 5 PhD phd NN cord-265322-3854ddb9 55 6 20 20 CD cord-265322-3854ddb9 55 7 . . . cord-265322-3854ddb9 55 8 21 21 CD cord-265322-3854ddb9 55 9 . . .