id sid tid token lemma pos cord-254411-e9vvjv8w 1 1 key key NN cord-254411-e9vvjv8w 1 2 : : : cord-254411-e9vvjv8w 1 3 cord-254411-e9vvjv8w cord-254411-e9vvjv8w NN cord-254411-e9vvjv8w 1 4 authors author NNS cord-254411-e9vvjv8w 1 5 : : : cord-254411-e9vvjv8w 1 6 Taghizadeh Taghizadeh NNP cord-254411-e9vvjv8w 1 7 - - HYPH cord-254411-e9vvjv8w 1 8 Hesary Hesary NNP cord-254411-e9vvjv8w 1 9 , , , cord-254411-e9vvjv8w 1 10 Farzad Farzad NNP cord-254411-e9vvjv8w 1 11 ; ; : cord-254411-e9vvjv8w 1 12 Akbari Akbari NNP cord-254411-e9vvjv8w 1 13 , , , cord-254411-e9vvjv8w 2 1 Hassan Hassan NNP cord-254411-e9vvjv8w 2 2 title title NN cord-254411-e9vvjv8w 2 3 : : : cord-254411-e9vvjv8w 2 4 The the DT cord-254411-e9vvjv8w 2 5 Powerful powerful JJ cord-254411-e9vvjv8w 2 6 Immune Immune NNP cord-254411-e9vvjv8w 2 7 System system NN cord-254411-e9vvjv8w 2 8 Against against IN cord-254411-e9vvjv8w 2 9 Powerful Powerful NNP cord-254411-e9vvjv8w 2 10 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 2 11 : : : cord-254411-e9vvjv8w 2 12 A a DT cord-254411-e9vvjv8w 2 13 Hypothesis Hypothesis NNP cord-254411-e9vvjv8w 2 14 date date NN cord-254411-e9vvjv8w 2 15 : : : cord-254411-e9vvjv8w 2 16 2020 2020 CD cord-254411-e9vvjv8w 2 17 - - HYPH cord-254411-e9vvjv8w 2 18 04 04 CD cord-254411-e9vvjv8w 2 19 - - SYM cord-254411-e9vvjv8w 2 20 22 22 CD cord-254411-e9vvjv8w 2 21 journal journal NN cord-254411-e9vvjv8w 2 22 : : : cord-254411-e9vvjv8w 3 1 Med Med NNP cord-254411-e9vvjv8w 3 2 Hypotheses Hypotheses NNP cord-254411-e9vvjv8w 3 3 DOI DOI NNP cord-254411-e9vvjv8w 3 4 : : : cord-254411-e9vvjv8w 3 5 10.1016 10.1016 CD cord-254411-e9vvjv8w 3 6 / / SYM cord-254411-e9vvjv8w 3 7 j.mehy.2020.109762 j.mehy.2020.109762 NNS cord-254411-e9vvjv8w 3 8 sha sha NNP cord-254411-e9vvjv8w 3 9 : : : cord-254411-e9vvjv8w 3 10 93edb6118d67de8bf75d1950e896d79b84597ee0 93edb6118d67de8bf75d1950e896d79b84597ee0 CD cord-254411-e9vvjv8w 3 11 doc_id doc_id CD cord-254411-e9vvjv8w 3 12 : : : cord-254411-e9vvjv8w 3 13 254411 254411 CD cord-254411-e9vvjv8w 3 14 cord_uid cord_uid NNS cord-254411-e9vvjv8w 3 15 : : : cord-254411-e9vvjv8w 4 1 e9vvjv8w e9vvjv8w CD cord-254411-e9vvjv8w 5 1 On on IN cord-254411-e9vvjv8w 5 2 March March NNP cord-254411-e9vvjv8w 5 3 11 11 CD cord-254411-e9vvjv8w 5 4 , , , cord-254411-e9vvjv8w 5 5 2020 2020 CD cord-254411-e9vvjv8w 5 6 , , , cord-254411-e9vvjv8w 5 7 the the DT cord-254411-e9vvjv8w 5 8 World World NNP cord-254411-e9vvjv8w 5 9 Health Health NNP cord-254411-e9vvjv8w 5 10 Organization Organization NNP cord-254411-e9vvjv8w 5 11 declared declare VBD cord-254411-e9vvjv8w 5 12 the the DT cord-254411-e9vvjv8w 5 13 coronavirus coronavirus NN cord-254411-e9vvjv8w 5 14 outbreak outbreak NN cord-254411-e9vvjv8w 5 15 a a DT cord-254411-e9vvjv8w 5 16 pandemic pandemic NN cord-254411-e9vvjv8w 5 17 . . . cord-254411-e9vvjv8w 6 1 Since since IN cord-254411-e9vvjv8w 6 2 December December NNP cord-254411-e9vvjv8w 6 3 2019 2019 CD cord-254411-e9vvjv8w 6 4 , , , cord-254411-e9vvjv8w 6 5 the the DT cord-254411-e9vvjv8w 6 6 world world NN cord-254411-e9vvjv8w 6 7 has have VBZ cord-254411-e9vvjv8w 6 8 experienced experience VBN cord-254411-e9vvjv8w 6 9 an an DT cord-254411-e9vvjv8w 6 10 outbreak outbreak NN cord-254411-e9vvjv8w 6 11 of of IN cord-254411-e9vvjv8w 6 12 coronavirus coronavirus NN cord-254411-e9vvjv8w 6 13 disease disease NN cord-254411-e9vvjv8w 6 14 2019 2019 CD cord-254411-e9vvjv8w 6 15 ( ( -LRB- cord-254411-e9vvjv8w 6 16 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 6 17 ) ) -RRB- cord-254411-e9vvjv8w 6 18 . . . cord-254411-e9vvjv8w 7 1 Epidemiology epidemiology NN cord-254411-e9vvjv8w 7 2 , , , cord-254411-e9vvjv8w 7 3 risk risk NN cord-254411-e9vvjv8w 7 4 factors factor NNS cord-254411-e9vvjv8w 7 5 , , , cord-254411-e9vvjv8w 7 6 and and CC cord-254411-e9vvjv8w 7 7 clinical clinical JJ cord-254411-e9vvjv8w 7 8 characteristics characteristic NNS cord-254411-e9vvjv8w 7 9 of of IN cord-254411-e9vvjv8w 7 10 patients patient NNS cord-254411-e9vvjv8w 7 11 with with IN cord-254411-e9vvjv8w 7 12 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 7 13 have have VBP cord-254411-e9vvjv8w 7 14 been be VBN cord-254411-e9vvjv8w 7 15 reported report VBN cord-254411-e9vvjv8w 7 16 but but CC cord-254411-e9vvjv8w 7 17 the the DT cord-254411-e9vvjv8w 7 18 factors factor NNS cord-254411-e9vvjv8w 7 19 affecting affect VBG cord-254411-e9vvjv8w 7 20 the the DT cord-254411-e9vvjv8w 7 21 immune immune JJ cord-254411-e9vvjv8w 7 22 system system NN cord-254411-e9vvjv8w 7 23 against against IN cord-254411-e9vvjv8w 7 24 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 7 25 have have VBP cord-254411-e9vvjv8w 7 26 not not RB cord-254411-e9vvjv8w 7 27 been be VBN cord-254411-e9vvjv8w 7 28 well well RB cord-254411-e9vvjv8w 7 29 described describe VBN cord-254411-e9vvjv8w 7 30 . . . cord-254411-e9vvjv8w 8 1 In in IN cord-254411-e9vvjv8w 8 2 this this DT cord-254411-e9vvjv8w 8 3 article article NN cord-254411-e9vvjv8w 8 4 , , , cord-254411-e9vvjv8w 8 5 we -PRON- PRP cord-254411-e9vvjv8w 8 6 provide provide VBP cord-254411-e9vvjv8w 8 7 a a DT cord-254411-e9vvjv8w 8 8 novel novel JJ cord-254411-e9vvjv8w 8 9 hypothesis hypothesis NN cord-254411-e9vvjv8w 8 10 to to TO cord-254411-e9vvjv8w 8 11 describe describe VB cord-254411-e9vvjv8w 8 12 how how WRB cord-254411-e9vvjv8w 8 13 an an DT cord-254411-e9vvjv8w 8 14 increase increase NN cord-254411-e9vvjv8w 8 15 in in IN cord-254411-e9vvjv8w 8 16 cellular cellular JJ cord-254411-e9vvjv8w 8 17 adenosine adenosine NN cord-254411-e9vvjv8w 8 18 triphosphate triphosphate NN cord-254411-e9vvjv8w 8 19 ( ( -LRB- cord-254411-e9vvjv8w 8 20 c c NNP cord-254411-e9vvjv8w 8 21 - - HYPH cord-254411-e9vvjv8w 8 22 ATP ATP NNP cord-254411-e9vvjv8w 8 23 ) ) -RRB- cord-254411-e9vvjv8w 8 24 can can MD cord-254411-e9vvjv8w 8 25 potentially potentially RB cord-254411-e9vvjv8w 8 26 improve improve VB cord-254411-e9vvjv8w 8 27 the the DT cord-254411-e9vvjv8w 8 28 efficiency efficiency NN cord-254411-e9vvjv8w 8 29 of of IN cord-254411-e9vvjv8w 8 30 innate innate JJ cord-254411-e9vvjv8w 8 31 and and CC cord-254411-e9vvjv8w 8 32 adaptive adaptive JJ cord-254411-e9vvjv8w 8 33 immune immune JJ cord-254411-e9vvjv8w 8 34 systems system NNS cord-254411-e9vvjv8w 8 35 to to TO cord-254411-e9vvjv8w 8 36 either either CC cord-254411-e9vvjv8w 8 37 prevent prevent VB cord-254411-e9vvjv8w 8 38 and and CC cord-254411-e9vvjv8w 8 39 fight fight VB cord-254411-e9vvjv8w 8 40 off off RP cord-254411-e9vvjv8w 8 41 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 8 42 . . . cord-254411-e9vvjv8w 9 1 Today today NN cord-254411-e9vvjv8w 9 2 , , , cord-254411-e9vvjv8w 9 3 the the DT cord-254411-e9vvjv8w 9 4 rapid rapid JJ cord-254411-e9vvjv8w 9 5 outbreak outbreak NN cord-254411-e9vvjv8w 9 6 of of IN cord-254411-e9vvjv8w 9 7 Corona Corona NNP cord-254411-e9vvjv8w 9 8 Virus Virus NNP cord-254411-e9vvjv8w 9 9 Disease Disease NNP cord-254411-e9vvjv8w 9 10 2019 2019 CD cord-254411-e9vvjv8w 9 11 ( ( -LRB- cord-254411-e9vvjv8w 9 12 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 9 13 or or CC cord-254411-e9vvjv8w 9 14 SARS SARS NNP cord-254411-e9vvjv8w 9 15 - - HYPH cord-254411-e9vvjv8w 9 16 CoV-2 CoV-2 NNP cord-254411-e9vvjv8w 9 17 ) ) -RRB- cord-254411-e9vvjv8w 9 18 is be VBZ cord-254411-e9vvjv8w 9 19 the the DT cord-254411-e9vvjv8w 9 20 leading lead VBG cord-254411-e9vvjv8w 9 21 health health NN cord-254411-e9vvjv8w 9 22 issue issue NN cord-254411-e9vvjv8w 9 23 . . . cord-254411-e9vvjv8w 10 1 There there EX cord-254411-e9vvjv8w 10 2 is be VBZ cord-254411-e9vvjv8w 10 3 a a DT cord-254411-e9vvjv8w 10 4 paucity paucity NN cord-254411-e9vvjv8w 10 5 of of IN cord-254411-e9vvjv8w 10 6 studies study NNS cord-254411-e9vvjv8w 10 7 investigating investigate VBG cord-254411-e9vvjv8w 10 8 the the DT cord-254411-e9vvjv8w 10 9 factors factor NNS cord-254411-e9vvjv8w 10 10 affecting affect VBG cord-254411-e9vvjv8w 10 11 immune immune JJ cord-254411-e9vvjv8w 10 12 response response NN cord-254411-e9vvjv8w 10 13 to to IN cord-254411-e9vvjv8w 10 14 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 10 15 . . . cord-254411-e9vvjv8w 11 1 In in IN cord-254411-e9vvjv8w 11 2 addition addition NN cord-254411-e9vvjv8w 11 3 , , , cord-254411-e9vvjv8w 11 4 there there EX cord-254411-e9vvjv8w 11 5 has have VBZ cord-254411-e9vvjv8w 11 6 been be VBN cord-254411-e9vvjv8w 11 7 no no DT cord-254411-e9vvjv8w 11 8 detailed detailed JJ cord-254411-e9vvjv8w 11 9 report report NN cord-254411-e9vvjv8w 11 10 for for IN cord-254411-e9vvjv8w 11 11 this this DT cord-254411-e9vvjv8w 11 12 immune immune JJ cord-254411-e9vvjv8w 11 13 response response NN cord-254411-e9vvjv8w 11 14 . . . cord-254411-e9vvjv8w 12 1 Given give VBN cord-254411-e9vvjv8w 12 2 the the DT cord-254411-e9vvjv8w 12 3 genomic genomic JJ cord-254411-e9vvjv8w 12 4 similarity similarity NN cord-254411-e9vvjv8w 12 5 of of IN cord-254411-e9vvjv8w 12 6 79 79 CD cord-254411-e9vvjv8w 12 7 % % NN cord-254411-e9vvjv8w 12 8 with with IN cord-254411-e9vvjv8w 12 9 Severe severe JJ cord-254411-e9vvjv8w 12 10 Acute acute JJ cord-254411-e9vvjv8w 12 11 Respiratory Respiratory NNP cord-254411-e9vvjv8w 12 12 Syndrome Syndrome NNP cord-254411-e9vvjv8w 12 13 coronavirus coronavirus NN cord-254411-e9vvjv8w 12 14 ( ( -LRB- cord-254411-e9vvjv8w 12 15 SARS SARS NNP cord-254411-e9vvjv8w 12 16 - - HYPH cord-254411-e9vvjv8w 12 17 CoV CoV NNP cord-254411-e9vvjv8w 12 18 ) ) -RRB- cord-254411-e9vvjv8w 12 19 , , , cord-254411-e9vvjv8w 12 20 nearly nearly RB cord-254411-e9vvjv8w 12 21 the the DT cord-254411-e9vvjv8w 12 22 same same JJ cord-254411-e9vvjv8w 12 23 reaction reaction NN cord-254411-e9vvjv8w 12 24 to to IN cord-254411-e9vvjv8w 12 25 the the DT cord-254411-e9vvjv8w 12 26 immune immune JJ cord-254411-e9vvjv8w 12 27 system system NN cord-254411-e9vvjv8w 12 28 is be VBZ cord-254411-e9vvjv8w 12 29 expected expect VBN cord-254411-e9vvjv8w 12 30 for for IN cord-254411-e9vvjv8w 12 31 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 12 32 ( ( -LRB- cord-254411-e9vvjv8w 12 33 1 1 CD cord-254411-e9vvjv8w 12 34 ) ) -RRB- cord-254411-e9vvjv8w 12 35 . . . cord-254411-e9vvjv8w 13 1 In in IN cord-254411-e9vvjv8w 13 2 response response NN cord-254411-e9vvjv8w 13 3 to to IN cord-254411-e9vvjv8w 13 4 SARS SARS NNP cord-254411-e9vvjv8w 13 5 - - HYPH cord-254411-e9vvjv8w 13 6 CoV CoV NNP cord-254411-e9vvjv8w 13 7 , , , cord-254411-e9vvjv8w 13 8 both both DT cord-254411-e9vvjv8w 13 9 innate innate JJ cord-254411-e9vvjv8w 13 10 and and CC cord-254411-e9vvjv8w 13 11 adaptive adaptive JJ cord-254411-e9vvjv8w 13 12 immune immune JJ cord-254411-e9vvjv8w 13 13 systems system NNS cord-254411-e9vvjv8w 13 14 are be VBP cord-254411-e9vvjv8w 13 15 involved involve VBN cord-254411-e9vvjv8w 13 16 . . . cord-254411-e9vvjv8w 14 1 SARS SARS NNP cord-254411-e9vvjv8w 14 2 - - HYPH cord-254411-e9vvjv8w 14 3 CoV CoV NNP cord-254411-e9vvjv8w 14 4 applies apply VBZ cord-254411-e9vvjv8w 14 5 several several JJ cord-254411-e9vvjv8w 14 6 mechanisms mechanism NNS cord-254411-e9vvjv8w 14 7 to to TO cord-254411-e9vvjv8w 14 8 overcome overcome VB cord-254411-e9vvjv8w 14 9 the the DT cord-254411-e9vvjv8w 14 10 immune immune JJ cord-254411-e9vvjv8w 14 11 response response NN cord-254411-e9vvjv8w 14 12 . . . cord-254411-e9vvjv8w 15 1 First first RB cord-254411-e9vvjv8w 15 2 , , , cord-254411-e9vvjv8w 15 3 it -PRON- PRP cord-254411-e9vvjv8w 15 4 inhibits inhibit VBZ cord-254411-e9vvjv8w 15 5 the the DT cord-254411-e9vvjv8w 15 6 rapid rapid JJ cord-254411-e9vvjv8w 15 7 expression expression NN cord-254411-e9vvjv8w 15 8 of of IN cord-254411-e9vvjv8w 15 9 interferon interferon NN cord-254411-e9vvjv8w 15 10 type type NN cord-254411-e9vvjv8w 15 11 1 1 CD cord-254411-e9vvjv8w 15 12 ( ( -LRB- cord-254411-e9vvjv8w 15 13 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 15 14 ) ) -RRB- cord-254411-e9vvjv8w 15 15 ( ( -LRB- cord-254411-e9vvjv8w 15 16 2 2 CD cord-254411-e9vvjv8w 15 17 ) ) -RRB- cord-254411-e9vvjv8w 15 18 . . . cord-254411-e9vvjv8w 16 1 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 16 2 is be VBZ cord-254411-e9vvjv8w 16 3 known know VBN cord-254411-e9vvjv8w 16 4 as as IN cord-254411-e9vvjv8w 16 5 the the DT cord-254411-e9vvjv8w 16 6 " " `` cord-254411-e9vvjv8w 16 7 initial initial JJ cord-254411-e9vvjv8w 16 8 alarm alarm NN cord-254411-e9vvjv8w 16 9 " " '' cord-254411-e9vvjv8w 16 10 upon upon IN cord-254411-e9vvjv8w 16 11 encounter encounter NN cord-254411-e9vvjv8w 16 12 with with IN cord-254411-e9vvjv8w 16 13 the the DT cord-254411-e9vvjv8w 16 14 virus virus NN cord-254411-e9vvjv8w 16 15 that that WDT cord-254411-e9vvjv8w 16 16 modulates modulate VBZ cord-254411-e9vvjv8w 16 17 the the DT cord-254411-e9vvjv8w 16 18 immune immune JJ cord-254411-e9vvjv8w 16 19 cells cell NNS cord-254411-e9vvjv8w 16 20 to to IN cord-254411-e9vvjv8w 16 21 the the DT cord-254411-e9vvjv8w 16 22 so so RB cord-254411-e9vvjv8w 16 23 - - HYPH cord-254411-e9vvjv8w 16 24 called call VBN cord-254411-e9vvjv8w 16 25 " " `` cord-254411-e9vvjv8w 16 26 antiviral antiviral JJ cord-254411-e9vvjv8w 16 27 state state NN cord-254411-e9vvjv8w 16 28 " " '' cord-254411-e9vvjv8w 16 29 . . . cord-254411-e9vvjv8w 17 1 Moreover moreover RB cord-254411-e9vvjv8w 17 2 , , , cord-254411-e9vvjv8w 17 3 SARS SARS NNP cord-254411-e9vvjv8w 17 4 - - HYPH cord-254411-e9vvjv8w 17 5 CoV CoV NNP cord-254411-e9vvjv8w 17 6 interferes interfere VBZ cord-254411-e9vvjv8w 17 7 with with IN cord-254411-e9vvjv8w 17 8 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 17 9 signaling signal VBG cord-254411-e9vvjv8w 17 10 through through IN cord-254411-e9vvjv8w 17 11 inhibition inhibition NN cord-254411-e9vvjv8w 17 12 of of IN cord-254411-e9vvjv8w 17 13 STAT-1 STAT-1 NNS cord-254411-e9vvjv8w 17 14 phosphorylation phosphorylation NN cord-254411-e9vvjv8w 17 15 ( ( -LRB- cord-254411-e9vvjv8w 17 16 3 3 CD cord-254411-e9vvjv8w 17 17 ) ) -RRB- cord-254411-e9vvjv8w 17 18 . . . cord-254411-e9vvjv8w 18 1 The the DT cord-254411-e9vvjv8w 18 2 third third JJ cord-254411-e9vvjv8w 18 3 defensive defensive JJ cord-254411-e9vvjv8w 18 4 mechanism mechanism NN cord-254411-e9vvjv8w 18 5 of of IN cord-254411-e9vvjv8w 18 6 SARS SARS NNP cord-254411-e9vvjv8w 18 7 - - HYPH cord-254411-e9vvjv8w 18 8 CoV CoV NNP cord-254411-e9vvjv8w 18 9 is be VBZ cord-254411-e9vvjv8w 18 10 immune immune JJ cord-254411-e9vvjv8w 18 11 exhaustion exhaustion NN cord-254411-e9vvjv8w 18 12 through through IN cord-254411-e9vvjv8w 18 13 exaggerated exaggerated JJ cord-254411-e9vvjv8w 18 14 and and CC cord-254411-e9vvjv8w 18 15 prolonged prolong VBN cord-254411-e9vvjv8w 18 16 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 18 17 production production NN cord-254411-e9vvjv8w 18 18 by by IN cord-254411-e9vvjv8w 18 19 plasmacytoid plasmacytoid NNP cord-254411-e9vvjv8w 18 20 dendritic dendritic JJ cord-254411-e9vvjv8w 18 21 cells cell NNS cord-254411-e9vvjv8w 18 22 ( ( -LRB- cord-254411-e9vvjv8w 18 23 pDCs pDCs NNP cord-254411-e9vvjv8w 18 24 ) ) -RRB- cord-254411-e9vvjv8w 18 25 . . . cord-254411-e9vvjv8w 19 1 This this DT cord-254411-e9vvjv8w 19 2 process process NN cord-254411-e9vvjv8w 19 3 leads lead VBZ cord-254411-e9vvjv8w 19 4 to to IN cord-254411-e9vvjv8w 19 5 the the DT cord-254411-e9vvjv8w 19 6 influx influx NN cord-254411-e9vvjv8w 19 7 of of IN cord-254411-e9vvjv8w 19 8 activated activate VBN cord-254411-e9vvjv8w 19 9 neutrophils neutrophil NNS cord-254411-e9vvjv8w 19 10 and and CC cord-254411-e9vvjv8w 19 11 inflammatory inflammatory JJ cord-254411-e9vvjv8w 19 12 monocytes monocyte NNS cord-254411-e9vvjv8w 19 13 / / SYM cord-254411-e9vvjv8w 19 14 macrophages macrophage NNS cord-254411-e9vvjv8w 19 15 , , , cord-254411-e9vvjv8w 19 16 that that IN cord-254411-e9vvjv8w 19 17 in in IN cord-254411-e9vvjv8w 19 18 turn turn NN cord-254411-e9vvjv8w 19 19 , , , cord-254411-e9vvjv8w 19 20 results result NNS cord-254411-e9vvjv8w 19 21 in in IN cord-254411-e9vvjv8w 19 22 lung lung NN cord-254411-e9vvjv8w 19 23 immunopathology immunopathology NN cord-254411-e9vvjv8w 19 24 ( ( -LRB- cord-254411-e9vvjv8w 19 25 e.g. e.g. IN cord-254411-e9vvjv8w 19 26 acute acute JJ cord-254411-e9vvjv8w 19 27 respiratory respiratory JJ cord-254411-e9vvjv8w 19 28 distress distress NN cord-254411-e9vvjv8w 19 29 syndrome syndrome NN cord-254411-e9vvjv8w 19 30 ) ) -RRB- cord-254411-e9vvjv8w 19 31 ( ( -LRB- cord-254411-e9vvjv8w 19 32 4 4 CD cord-254411-e9vvjv8w 19 33 ) ) -RRB- cord-254411-e9vvjv8w 19 34 . . . cord-254411-e9vvjv8w 20 1 Finally finally RB cord-254411-e9vvjv8w 20 2 , , , cord-254411-e9vvjv8w 20 3 the the DT cord-254411-e9vvjv8w 20 4 resulted result VBN cord-254411-e9vvjv8w 20 5 so so RB cord-254411-e9vvjv8w 20 6 - - HYPH cord-254411-e9vvjv8w 20 7 called call VBN cord-254411-e9vvjv8w 20 8 " " `` cord-254411-e9vvjv8w 20 9 cytokine cytokine NN cord-254411-e9vvjv8w 20 10 storm storm NN cord-254411-e9vvjv8w 20 11 " " '' cord-254411-e9vvjv8w 20 12 further further RB cord-254411-e9vvjv8w 20 13 weakens weaken VBZ cord-254411-e9vvjv8w 20 14 the the DT cord-254411-e9vvjv8w 20 15 immune immune JJ cord-254411-e9vvjv8w 20 16 system system NN cord-254411-e9vvjv8w 20 17 through through IN cord-254411-e9vvjv8w 20 18 IFN-1-mediated ifn-1-mediate VBN cord-254411-e9vvjv8w 20 19 T T NNP cord-254411-e9vvjv8w 20 20 cell cell NN cord-254411-e9vvjv8w 20 21 apoptosis apoptosis NN cord-254411-e9vvjv8w 20 22 ( ( -LRB- cord-254411-e9vvjv8w 20 23 5 5 CD cord-254411-e9vvjv8w 20 24 ) ) -RRB- cord-254411-e9vvjv8w 20 25 . . . cord-254411-e9vvjv8w 21 1 In in IN cord-254411-e9vvjv8w 21 2 this this DT cord-254411-e9vvjv8w 21 3 article article NN cord-254411-e9vvjv8w 21 4 , , , cord-254411-e9vvjv8w 21 5 we -PRON- PRP cord-254411-e9vvjv8w 21 6 aim aim VBP cord-254411-e9vvjv8w 21 7 to to TO cord-254411-e9vvjv8w 21 8 provide provide VB cord-254411-e9vvjv8w 21 9 a a DT cord-254411-e9vvjv8w 21 10 new new JJ cord-254411-e9vvjv8w 21 11 hypothesis hypothesis NN cord-254411-e9vvjv8w 21 12 to to TO cord-254411-e9vvjv8w 21 13 describe describe VB cord-254411-e9vvjv8w 21 14 how how WRB cord-254411-e9vvjv8w 21 15 the the DT cord-254411-e9vvjv8w 21 16 repletion repletion NN cord-254411-e9vvjv8w 21 17 of of IN cord-254411-e9vvjv8w 21 18 cellular cellular JJ cord-254411-e9vvjv8w 21 19 adenosine adenosine NN cord-254411-e9vvjv8w 21 20 triphosphate triphosphate NN cord-254411-e9vvjv8w 21 21 ( ( -LRB- cord-254411-e9vvjv8w 21 22 c c NNP cord-254411-e9vvjv8w 21 23 - - HYPH cord-254411-e9vvjv8w 21 24 ATP ATP NNP cord-254411-e9vvjv8w 21 25 ) ) -RRB- cord-254411-e9vvjv8w 21 26 can can MD cord-254411-e9vvjv8w 21 27 promote promote VB cord-254411-e9vvjv8w 21 28 immunity immunity NN cord-254411-e9vvjv8w 21 29 against against IN cord-254411-e9vvjv8w 21 30 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 21 31 . . . cord-254411-e9vvjv8w 22 1 Thereafter thereafter RB cord-254411-e9vvjv8w 22 2 , , , cord-254411-e9vvjv8w 22 3 we -PRON- PRP cord-254411-e9vvjv8w 22 4 justify justify VBP cord-254411-e9vvjv8w 22 5 the the DT cord-254411-e9vvjv8w 22 6 current current JJ cord-254411-e9vvjv8w 22 7 knowledge knowledge NN cord-254411-e9vvjv8w 22 8 regarding regard VBG cord-254411-e9vvjv8w 22 9 the the DT cord-254411-e9vvjv8w 22 10 characteristics characteristic NNS cord-254411-e9vvjv8w 22 11 of of IN cord-254411-e9vvjv8w 22 12 COVID-19 covid-19 JJ cord-254411-e9vvjv8w 22 13 infection infection NN cord-254411-e9vvjv8w 22 14 by by IN cord-254411-e9vvjv8w 22 15 our -PRON- PRP$ cord-254411-e9vvjv8w 22 16 hypothesis hypothesis NN cord-254411-e9vvjv8w 22 17 and and CC cord-254411-e9vvjv8w 22 18 give give VB cord-254411-e9vvjv8w 22 19 several several JJ cord-254411-e9vvjv8w 22 20 approaches approach NNS cord-254411-e9vvjv8w 22 21 to to TO cord-254411-e9vvjv8w 22 22 improve improve VB cord-254411-e9vvjv8w 22 23 the the DT cord-254411-e9vvjv8w 22 24 c c NNP cord-254411-e9vvjv8w 22 25 - - HYPH cord-254411-e9vvjv8w 22 26 ATP ATP NNP cord-254411-e9vvjv8w 22 27 . . . cord-254411-e9vvjv8w 23 1 Considering consider VBG cord-254411-e9vvjv8w 23 2 the the DT cord-254411-e9vvjv8w 23 3 pivotal pivotal JJ cord-254411-e9vvjv8w 23 4 role role NN cord-254411-e9vvjv8w 23 5 of of IN cord-254411-e9vvjv8w 23 6 ATP ATP NNP cord-254411-e9vvjv8w 23 7 in in IN cord-254411-e9vvjv8w 23 8 cellular cellular JJ cord-254411-e9vvjv8w 23 9 function function NN cord-254411-e9vvjv8w 23 10 , , , cord-254411-e9vvjv8w 23 11 c c NNP cord-254411-e9vvjv8w 23 12 - - HYPH cord-254411-e9vvjv8w 23 13 ATP ATP NNP cord-254411-e9vvjv8w 23 14 depletion depletion NN cord-254411-e9vvjv8w 23 15 can can MD cord-254411-e9vvjv8w 23 16 lead lead VB cord-254411-e9vvjv8w 23 17 to to IN cord-254411-e9vvjv8w 23 18 cellular cellular JJ cord-254411-e9vvjv8w 23 19 dysfunction dysfunction NN cord-254411-e9vvjv8w 23 20 ( ( -LRB- cord-254411-e9vvjv8w 23 21 6 6 CD cord-254411-e9vvjv8w 23 22 ) ) -RRB- cord-254411-e9vvjv8w 23 23 . . . cord-254411-e9vvjv8w 24 1 Immune immune JJ cord-254411-e9vvjv8w 24 2 cells cell NNS cord-254411-e9vvjv8w 24 3 are be VBP cord-254411-e9vvjv8w 24 4 not not RB cord-254411-e9vvjv8w 24 5 an an DT cord-254411-e9vvjv8w 24 6 exception exception NN cord-254411-e9vvjv8w 24 7 . . . cord-254411-e9vvjv8w 25 1 In in IN cord-254411-e9vvjv8w 25 2 this this DT cord-254411-e9vvjv8w 25 3 article article NN cord-254411-e9vvjv8w 25 4 , , , cord-254411-e9vvjv8w 25 5 c c NNP cord-254411-e9vvjv8w 25 6 - - : cord-254411-e9vvjv8w 25 7 ATP ATP NNP cord-254411-e9vvjv8w 25 8 is be VBZ cord-254411-e9vvjv8w 25 9 the the DT cord-254411-e9vvjv8w 25 10 index index NN cord-254411-e9vvjv8w 25 11 of of IN cord-254411-e9vvjv8w 25 12 cellular cellular JJ cord-254411-e9vvjv8w 25 13 energy energy NN cord-254411-e9vvjv8w 25 14 . . . cord-254411-e9vvjv8w 26 1 Here here RB cord-254411-e9vvjv8w 26 2 , , , cord-254411-e9vvjv8w 26 3 we -PRON- PRP cord-254411-e9vvjv8w 26 4 show show VBP cord-254411-e9vvjv8w 26 5 how how WRB cord-254411-e9vvjv8w 26 6 c c NNP cord-254411-e9vvjv8w 26 7 - - HYPH cord-254411-e9vvjv8w 26 8 ATP ATP NNP cord-254411-e9vvjv8w 26 9 repletion repletion NN cord-254411-e9vvjv8w 26 10 can can MD cord-254411-e9vvjv8w 26 11 counteract counteract VB cord-254411-e9vvjv8w 26 12 with with IN cord-254411-e9vvjv8w 26 13 defensive defensive JJ cord-254411-e9vvjv8w 26 14 mechanisms mechanism NNS cord-254411-e9vvjv8w 26 15 of of IN cord-254411-e9vvjv8w 26 16 COVID-19 covid-19 CD cord-254411-e9vvjv8w 26 17 and and CC cord-254411-e9vvjv8w 26 18 promote promote VB cord-254411-e9vvjv8w 26 19 the the DT cord-254411-e9vvjv8w 26 20 immune immune JJ cord-254411-e9vvjv8w 26 21 system system NN cord-254411-e9vvjv8w 26 22 to to IN cord-254411-e9vvjv8w 26 23 the the DT cord-254411-e9vvjv8w 26 24 enhancement enhancement NN cord-254411-e9vvjv8w 26 25 pathway pathway NN cord-254411-e9vvjv8w 26 26 . . . cord-254411-e9vvjv8w 27 1 3.1 3.1 LS cord-254411-e9vvjv8w 27 2 . . . cord-254411-e9vvjv8w 28 1 ATP ATP NNP cord-254411-e9vvjv8w 28 2 facilitates facilitate VBZ cord-254411-e9vvjv8w 28 3 IFN IFN NNP cord-254411-e9vvjv8w 28 4 production production NN cord-254411-e9vvjv8w 28 5 COVID-19 covid-19 NN cord-254411-e9vvjv8w 28 6 interferes interfere VBZ cord-254411-e9vvjv8w 28 7 with with IN cord-254411-e9vvjv8w 28 8 a a DT cord-254411-e9vvjv8w 28 9 rapid rapid JJ cord-254411-e9vvjv8w 28 10 rise rise NN cord-254411-e9vvjv8w 28 11 in in IN cord-254411-e9vvjv8w 28 12 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 28 13 . . . cord-254411-e9vvjv8w 29 1 Therefore therefore RB cord-254411-e9vvjv8w 29 2 , , , cord-254411-e9vvjv8w 29 3 it -PRON- PRP cord-254411-e9vvjv8w 29 4 deactivates deactivate VBZ cord-254411-e9vvjv8w 29 5 the the DT cord-254411-e9vvjv8w 29 6 so so RB cord-254411-e9vvjv8w 29 7 - - HYPH cord-254411-e9vvjv8w 29 8 called call VBN cord-254411-e9vvjv8w 29 9 " " `` cord-254411-e9vvjv8w 29 10 initial initial JJ cord-254411-e9vvjv8w 29 11 alarm alarm NN cord-254411-e9vvjv8w 29 12 " " '' cord-254411-e9vvjv8w 29 13 of of IN cord-254411-e9vvjv8w 29 14 the the DT cord-254411-e9vvjv8w 29 15 innate innate JJ cord-254411-e9vvjv8w 29 16 immune immune JJ cord-254411-e9vvjv8w 29 17 system system NN cord-254411-e9vvjv8w 29 18 , , , cord-254411-e9vvjv8w 29 19 by by IN cord-254411-e9vvjv8w 29 20 unknown unknown JJ cord-254411-e9vvjv8w 29 21 mechanisms mechanism NNS cord-254411-e9vvjv8w 29 22 . . . cord-254411-e9vvjv8w 30 1 This this DT cord-254411-e9vvjv8w 30 2 facilitates facilitate VBZ cord-254411-e9vvjv8w 30 3 its -PRON- PRP$ cord-254411-e9vvjv8w 30 4 replication replication NN cord-254411-e9vvjv8w 30 5 . . . cord-254411-e9vvjv8w 31 1 Zhang Zhang NNP cord-254411-e9vvjv8w 31 2 et et NNP cord-254411-e9vvjv8w 31 3 al al NNP cord-254411-e9vvjv8w 31 4 . . NNP cord-254411-e9vvjv8w 31 5 have have VBP cord-254411-e9vvjv8w 31 6 demonstrated demonstrate VBN cord-254411-e9vvjv8w 31 7 that that DT cord-254411-e9vvjv8w 31 8 enhancement enhancement NN cord-254411-e9vvjv8w 31 9 in in IN cord-254411-e9vvjv8w 31 10 the the DT cord-254411-e9vvjv8w 31 11 c c NNP cord-254411-e9vvjv8w 31 12 - - HYPH cord-254411-e9vvjv8w 31 13 ATP ATP NNP cord-254411-e9vvjv8w 31 14 can can MD cord-254411-e9vvjv8w 31 15 reverse reverse VB cord-254411-e9vvjv8w 31 16 this this DT cord-254411-e9vvjv8w 31 17 process process NN cord-254411-e9vvjv8w 31 18 . . . cord-254411-e9vvjv8w 32 1 This this DT cord-254411-e9vvjv8w 32 2 occurs occur VBZ cord-254411-e9vvjv8w 32 3 by by IN cord-254411-e9vvjv8w 32 4 the the DT cord-254411-e9vvjv8w 32 5 facilitation facilitation NN cord-254411-e9vvjv8w 32 6 of of IN cord-254411-e9vvjv8w 32 7 IFN IFN NNP cord-254411-e9vvjv8w 32 8 secretion secretion NN cord-254411-e9vvjv8w 32 9 through through IN cord-254411-e9vvjv8w 32 10 P38 P38 NNP cord-254411-e9vvjv8w 32 11 / / SYM cord-254411-e9vvjv8w 32 12 JNK JNK NNP cord-254411-e9vvjv8w 32 13 / / SYM cord-254411-e9vvjv8w 32 14 ATF-2 ATF-2 NNP cord-254411-e9vvjv8w 32 15 signaling signal VBG cord-254411-e9vvjv8w 32 16 pathway pathway NN cord-254411-e9vvjv8w 32 17 ( ( -LRB- cord-254411-e9vvjv8w 32 18 7 7 CD cord-254411-e9vvjv8w 32 19 ) ) -RRB- cord-254411-e9vvjv8w 32 20 . . . cord-254411-e9vvjv8w 33 1 Therefore therefore RB cord-254411-e9vvjv8w 33 2 , , , cord-254411-e9vvjv8w 33 3 ATP ATP NNP cord-254411-e9vvjv8w 33 4 - - HYPH cord-254411-e9vvjv8w 33 5 depleted deplete VBN cord-254411-e9vvjv8w 33 6 cells cell NNS cord-254411-e9vvjv8w 33 7 are be VBP cord-254411-e9vvjv8w 33 8 more more RBR cord-254411-e9vvjv8w 33 9 susceptible susceptible JJ cord-254411-e9vvjv8w 33 10 to to IN cord-254411-e9vvjv8w 33 11 this this DT cord-254411-e9vvjv8w 33 12 effect effect NN cord-254411-e9vvjv8w 33 13 of of IN cord-254411-e9vvjv8w 33 14 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 33 15 . . . cord-254411-e9vvjv8w 34 1 Following follow VBG cord-254411-e9vvjv8w 34 2 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 34 3 secretion secretion NN cord-254411-e9vvjv8w 34 4 , , , cord-254411-e9vvjv8w 34 5 fundamental fundamental JJ cord-254411-e9vvjv8w 34 6 changes change NNS cord-254411-e9vvjv8w 34 7 occur occur VBP cord-254411-e9vvjv8w 34 8 in in IN cord-254411-e9vvjv8w 34 9 the the DT cord-254411-e9vvjv8w 34 10 immune immune JJ cord-254411-e9vvjv8w 34 11 cells cell NNS cord-254411-e9vvjv8w 34 12 that that WDT cord-254411-e9vvjv8w 34 13 transform transform VBP cord-254411-e9vvjv8w 34 14 them -PRON- PRP cord-254411-e9vvjv8w 34 15 into into IN cord-254411-e9vvjv8w 34 16 the the DT cord-254411-e9vvjv8w 34 17 so so RB cord-254411-e9vvjv8w 34 18 - - HYPH cord-254411-e9vvjv8w 34 19 called call VBN cord-254411-e9vvjv8w 34 20 " " `` cord-254411-e9vvjv8w 34 21 antiviral antiviral JJ cord-254411-e9vvjv8w 34 22 state state NN cord-254411-e9vvjv8w 34 23 " " '' cord-254411-e9vvjv8w 34 24 . . . cord-254411-e9vvjv8w 35 1 One one CD cord-254411-e9vvjv8w 35 2 of of IN cord-254411-e9vvjv8w 35 3 the the DT cord-254411-e9vvjv8w 35 4 signaling signal VBG cord-254411-e9vvjv8w 35 5 pathways pathway NNS cord-254411-e9vvjv8w 35 6 that that WDT cord-254411-e9vvjv8w 35 7 take take VBP cord-254411-e9vvjv8w 35 8 part part NN cord-254411-e9vvjv8w 35 9 in in IN cord-254411-e9vvjv8w 35 10 this this DT cord-254411-e9vvjv8w 35 11 process process NN cord-254411-e9vvjv8w 35 12 is be VBZ cord-254411-e9vvjv8w 35 13 the the DT cord-254411-e9vvjv8w 35 14 JAK JAK NNP cord-254411-e9vvjv8w 35 15 / / SYM cord-254411-e9vvjv8w 35 16 STAT stat NN cord-254411-e9vvjv8w 35 17 pathway pathway NN cord-254411-e9vvjv8w 35 18 . . . cord-254411-e9vvjv8w 36 1 JAKs JAKs NNP cord-254411-e9vvjv8w 36 2 are be VBP cord-254411-e9vvjv8w 36 3 ATP ATP NNP cord-254411-e9vvjv8w 36 4 - - HYPH cord-254411-e9vvjv8w 36 5 dependent dependent JJ cord-254411-e9vvjv8w 36 6 enzymes enzyme NNS cord-254411-e9vvjv8w 36 7 that that WDT cord-254411-e9vvjv8w 36 8 are be VBP cord-254411-e9vvjv8w 36 9 bound bind VBN cord-254411-e9vvjv8w 36 10 to to IN cord-254411-e9vvjv8w 36 11 the the DT cord-254411-e9vvjv8w 36 12 cytoplasmic cytoplasmic JJ cord-254411-e9vvjv8w 36 13 regions region NNS cord-254411-e9vvjv8w 36 14 of of IN cord-254411-e9vvjv8w 36 15 cytokine cytokine JJ cord-254411-e9vvjv8w 36 16 receptors receptor NNS cord-254411-e9vvjv8w 36 17 . . . cord-254411-e9vvjv8w 37 1 Following follow VBG cord-254411-e9vvjv8w 37 2 attachment attachment NN cord-254411-e9vvjv8w 37 3 of of IN cord-254411-e9vvjv8w 37 4 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 37 5 to to IN cord-254411-e9vvjv8w 37 6 the the DT cord-254411-e9vvjv8w 37 7 cytokine cytokine NN cord-254411-e9vvjv8w 37 8 receptor receptor NN cord-254411-e9vvjv8w 37 9 , , , cord-254411-e9vvjv8w 37 10 JAK JAK NNP cord-254411-e9vvjv8w 37 11 activates activate VBZ cord-254411-e9vvjv8w 37 12 the the DT cord-254411-e9vvjv8w 37 13 STAT stat NN cord-254411-e9vvjv8w 37 14 through through IN cord-254411-e9vvjv8w 37 15 transphosphorylation transphosphorylation NN cord-254411-e9vvjv8w 37 16 ( ( -LRB- cord-254411-e9vvjv8w 37 17 8) 8) NNP cord-254411-e9vvjv8w 37 18 . . . cord-254411-e9vvjv8w 38 1 Obviously obviously RB cord-254411-e9vvjv8w 38 2 , , , cord-254411-e9vvjv8w 38 3 c c LS cord-254411-e9vvjv8w 38 4 - - HYPH cord-254411-e9vvjv8w 38 5 ATP ATP NNP cord-254411-e9vvjv8w 38 6 depletion depletion NN cord-254411-e9vvjv8w 38 7 interferes interfere VBZ cord-254411-e9vvjv8w 38 8 with with IN cord-254411-e9vvjv8w 38 9 this this DT cord-254411-e9vvjv8w 38 10 process process NN cord-254411-e9vvjv8w 38 11 and and CC cord-254411-e9vvjv8w 38 12 further far RBR cord-254411-e9vvjv8w 38 13 impairs impair VBZ cord-254411-e9vvjv8w 38 14 transformation transformation NN cord-254411-e9vvjv8w 38 15 to to IN cord-254411-e9vvjv8w 38 16 " " `` cord-254411-e9vvjv8w 38 17 antiviral antiviral JJ cord-254411-e9vvjv8w 38 18 state state NN cord-254411-e9vvjv8w 38 19 " " '' cord-254411-e9vvjv8w 38 20 . . . cord-254411-e9vvjv8w 39 1 Following follow VBG cord-254411-e9vvjv8w 39 2 deactivation deactivation NN cord-254411-e9vvjv8w 39 3 of of IN cord-254411-e9vvjv8w 39 4 " " `` cord-254411-e9vvjv8w 39 5 initial initial JJ cord-254411-e9vvjv8w 39 6 alarm alarm NN cord-254411-e9vvjv8w 39 7 " " '' cord-254411-e9vvjv8w 39 8 , , , cord-254411-e9vvjv8w 39 9 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 39 10 easily easily RB cord-254411-e9vvjv8w 39 11 proliferates proliferate VBZ cord-254411-e9vvjv8w 39 12 in in IN cord-254411-e9vvjv8w 39 13 - - HYPH cord-254411-e9vvjv8w 39 14 situ situ NN cord-254411-e9vvjv8w 39 15 . . . cord-254411-e9vvjv8w 40 1 Among among IN cord-254411-e9vvjv8w 40 2 the the DT cord-254411-e9vvjv8w 40 3 passive passive JJ cord-254411-e9vvjv8w 40 4 hostcells hostcell NNS cord-254411-e9vvjv8w 40 5 , , , cord-254411-e9vvjv8w 40 6 there there EX cord-254411-e9vvjv8w 40 7 are be VBP cord-254411-e9vvjv8w 40 8 exceptions exception NNS cord-254411-e9vvjv8w 40 9 that that WDT cord-254411-e9vvjv8w 40 10 can can MD cord-254411-e9vvjv8w 40 11 react react VB cord-254411-e9vvjv8w 40 12 to to IN cord-254411-e9vvjv8w 40 13 the the DT cord-254411-e9vvjv8w 40 14 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 40 15 , , , cord-254411-e9vvjv8w 40 16 the the DT cord-254411-e9vvjv8w 40 17 pDCs pdcs NN cord-254411-e9vvjv8w 40 18 . . . cord-254411-e9vvjv8w 41 1 They -PRON- PRP cord-254411-e9vvjv8w 41 2 detect detect VBP cord-254411-e9vvjv8w 41 3 the the DT cord-254411-e9vvjv8w 41 4 virus virus NN cord-254411-e9vvjv8w 41 5 by by IN cord-254411-e9vvjv8w 41 6 toll toll NN cord-254411-e9vvjv8w 41 7 - - HYPH cord-254411-e9vvjv8w 41 8 like like JJ cord-254411-e9vvjv8w 41 9 receptor receptor NN cord-254411-e9vvjv8w 41 10 7 7 CD cord-254411-e9vvjv8w 41 11 ( ( -LRB- cord-254411-e9vvjv8w 41 12 TLR-7 TLR-7 NNP cord-254411-e9vvjv8w 41 13 ) ) -RRB- cord-254411-e9vvjv8w 41 14 . . . cord-254411-e9vvjv8w 42 1 Upon upon IN cord-254411-e9vvjv8w 42 2 attachment attachment NN cord-254411-e9vvjv8w 42 3 to to IN cord-254411-e9vvjv8w 42 4 viral viral JJ cord-254411-e9vvjv8w 42 5 nucleic nucleic JJ cord-254411-e9vvjv8w 42 6 acids acid NNS cord-254411-e9vvjv8w 42 7 , , , cord-254411-e9vvjv8w 42 8 TLR7 TLR7 NNP cord-254411-e9vvjv8w 42 9 induces induce VBZ cord-254411-e9vvjv8w 42 10 profound profound JJ cord-254411-e9vvjv8w 42 11 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 42 12 expression expression NN cord-254411-e9vvjv8w 42 13 . . . cord-254411-e9vvjv8w 43 1 This this DT cord-254411-e9vvjv8w 43 2 response response NN cord-254411-e9vvjv8w 43 3 recruits recruit VBZ cord-254411-e9vvjv8w 43 4 other other JJ cord-254411-e9vvjv8w 43 5 immune immune JJ cord-254411-e9vvjv8w 43 6 cells cell NNS cord-254411-e9vvjv8w 43 7 and and CC cord-254411-e9vvjv8w 43 8 causes cause VBZ cord-254411-e9vvjv8w 43 9 massive massive JJ cord-254411-e9vvjv8w 43 10 local local JJ cord-254411-e9vvjv8w 43 11 inflammation inflammation NN cord-254411-e9vvjv8w 43 12 ( ( -LRB- cord-254411-e9vvjv8w 43 13 9 9 CD cord-254411-e9vvjv8w 43 14 ) ) -RRB- cord-254411-e9vvjv8w 43 15 . . . cord-254411-e9vvjv8w 44 1 At at IN cord-254411-e9vvjv8w 44 2 first first JJ cord-254411-e9vvjv8w 44 3 glance glance NN cord-254411-e9vvjv8w 44 4 , , , cord-254411-e9vvjv8w 44 5 this this DT cord-254411-e9vvjv8w 44 6 robust robust JJ cord-254411-e9vvjv8w 44 7 immune immune JJ cord-254411-e9vvjv8w 44 8 response response NN cord-254411-e9vvjv8w 44 9 is be VBZ cord-254411-e9vvjv8w 44 10 beneficial beneficial JJ cord-254411-e9vvjv8w 44 11 for for IN cord-254411-e9vvjv8w 44 12 the the DT cord-254411-e9vvjv8w 44 13 elimination elimination NN cord-254411-e9vvjv8w 44 14 of of IN cord-254411-e9vvjv8w 44 15 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 44 16 . . . cord-254411-e9vvjv8w 45 1 However however RB cord-254411-e9vvjv8w 45 2 , , , cord-254411-e9vvjv8w 45 3 two two CD cord-254411-e9vvjv8w 45 4 factors factor NNS cord-254411-e9vvjv8w 45 5 prevent prevent VBP cord-254411-e9vvjv8w 45 6 it -PRON- PRP cord-254411-e9vvjv8w 45 7 . . . cord-254411-e9vvjv8w 46 1 First first RB cord-254411-e9vvjv8w 46 2 , , , cord-254411-e9vvjv8w 46 3 impairment impairment NN cord-254411-e9vvjv8w 46 4 of of IN cord-254411-e9vvjv8w 46 5 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 46 6 signaling signal VBG cord-254411-e9vvjv8w 46 7 results result NNS cord-254411-e9vvjv8w 46 8 in in IN cord-254411-e9vvjv8w 46 9 impairment impairment NN cord-254411-e9vvjv8w 46 10 of of IN cord-254411-e9vvjv8w 46 11 immune immune JJ cord-254411-e9vvjv8w 46 12 cell cell NN cord-254411-e9vvjv8w 46 13 transformation transformation NN cord-254411-e9vvjv8w 46 14 to to IN cord-254411-e9vvjv8w 46 15 the the DT cord-254411-e9vvjv8w 46 16 " " `` cord-254411-e9vvjv8w 46 17 antiviral antiviral JJ cord-254411-e9vvjv8w 46 18 state state NN cord-254411-e9vvjv8w 46 19 " " '' cord-254411-e9vvjv8w 46 20 . . . cord-254411-e9vvjv8w 47 1 Therefore therefore RB cord-254411-e9vvjv8w 47 2 , , , cord-254411-e9vvjv8w 47 3 they -PRON- PRP cord-254411-e9vvjv8w 47 4 are be VBP cord-254411-e9vvjv8w 47 5 not not RB cord-254411-e9vvjv8w 47 6 so so RB cord-254411-e9vvjv8w 47 7 effective effective JJ cord-254411-e9vvjv8w 47 8 in in IN cord-254411-e9vvjv8w 47 9 eliminating eliminate VBG cord-254411-e9vvjv8w 47 10 existing exist VBG cord-254411-e9vvjv8w 47 11 viruses virus NNS cord-254411-e9vvjv8w 47 12 ( ( -LRB- cord-254411-e9vvjv8w 47 13 8) 8) NNP cord-254411-e9vvjv8w 47 14 . . . cord-254411-e9vvjv8w 48 1 Second second RB cord-254411-e9vvjv8w 48 2 , , , cord-254411-e9vvjv8w 48 3 persistence persistence NN cord-254411-e9vvjv8w 48 4 profound profound JJ cord-254411-e9vvjv8w 48 5 inflammatory inflammatory JJ cord-254411-e9vvjv8w 48 6 responses response NNS cord-254411-e9vvjv8w 48 7 may may MD cord-254411-e9vvjv8w 48 8 lead lead VB cord-254411-e9vvjv8w 48 9 to to IN cord-254411-e9vvjv8w 48 10 immune immune JJ cord-254411-e9vvjv8w 48 11 exhaustion exhaustion NN cord-254411-e9vvjv8w 48 12 ( ( -LRB- cord-254411-e9vvjv8w 48 13 4 4 CD cord-254411-e9vvjv8w 48 14 ) ) -RRB- cord-254411-e9vvjv8w 48 15 . . . cord-254411-e9vvjv8w 49 1 The the DT cord-254411-e9vvjv8w 49 2 depletion depletion NN cord-254411-e9vvjv8w 49 3 of of IN cord-254411-e9vvjv8w 49 4 c c NN cord-254411-e9vvjv8w 49 5 - - : cord-254411-e9vvjv8w 49 6 ATP ATP NNP cord-254411-e9vvjv8w 49 7 can can MD cord-254411-e9vvjv8w 49 8 potentially potentially RB cord-254411-e9vvjv8w 49 9 enhance enhance VB cord-254411-e9vvjv8w 49 10 these these DT cord-254411-e9vvjv8w 49 11 detrimental detrimental JJ cord-254411-e9vvjv8w 49 12 processes process NNS cord-254411-e9vvjv8w 49 13 in in IN cord-254411-e9vvjv8w 49 14 the the DT cord-254411-e9vvjv8w 49 15 following follow VBG cord-254411-e9vvjv8w 49 16 ways way NNS cord-254411-e9vvjv8w 49 17 . . . cord-254411-e9vvjv8w 50 1 In in IN cord-254411-e9vvjv8w 50 2 2016 2016 CD cord-254411-e9vvjv8w 50 3 , , , cord-254411-e9vvjv8w 50 4 Rebbapragada Rebbapragada NNP cord-254411-e9vvjv8w 50 5 et et NNP cord-254411-e9vvjv8w 50 6 al al NNP cord-254411-e9vvjv8w 50 7 . . NNP cord-254411-e9vvjv8w 50 8 demonstrated demonstrate VBD cord-254411-e9vvjv8w 50 9 the the DT cord-254411-e9vvjv8w 50 10 effect effect NN cord-254411-e9vvjv8w 50 11 of of IN cord-254411-e9vvjv8w 50 12 ATP ATP NNP cord-254411-e9vvjv8w 50 13 in in IN cord-254411-e9vvjv8w 50 14 the the DT cord-254411-e9vvjv8w 50 15 function function NN cord-254411-e9vvjv8w 50 16 of of IN cord-254411-e9vvjv8w 50 17 TLR7 TLR7 NNP cord-254411-e9vvjv8w 50 18 by by IN cord-254411-e9vvjv8w 50 19 controlling control VBG cord-254411-e9vvjv8w 50 20 the the DT cord-254411-e9vvjv8w 50 21 endo endo NN cord-254411-e9vvjv8w 50 22 - - HYPH cord-254411-e9vvjv8w 50 23 lysosomal lysosomal JJ cord-254411-e9vvjv8w 50 24 PH PH NNP cord-254411-e9vvjv8w 50 25 . . . cord-254411-e9vvjv8w 51 1 They -PRON- PRP cord-254411-e9vvjv8w 51 2 showed show VBD cord-254411-e9vvjv8w 51 3 that that IN cord-254411-e9vvjv8w 51 4 ATP ATP NNP cord-254411-e9vvjv8w 51 5 - - HYPH cord-254411-e9vvjv8w 51 6 depletion depletion NN cord-254411-e9vvjv8w 51 7 can can MD cord-254411-e9vvjv8w 51 8 increase increase VB cord-254411-e9vvjv8w 51 9 the the DT cord-254411-e9vvjv8w 51 10 endo endo NN cord-254411-e9vvjv8w 51 11 - - HYPH cord-254411-e9vvjv8w 51 12 lysosomal lysosomal JJ cord-254411-e9vvjv8w 51 13 PH PH NNP cord-254411-e9vvjv8w 51 14 and and CC cord-254411-e9vvjv8w 51 15 improve improve VB cord-254411-e9vvjv8w 51 16 the the DT cord-254411-e9vvjv8w 51 17 efficacy efficacy NN cord-254411-e9vvjv8w 51 18 of of IN cord-254411-e9vvjv8w 51 19 TLR7 TLR7 NNP cord-254411-e9vvjv8w 51 20 . . . cord-254411-e9vvjv8w 52 1 Therefore therefore RB cord-254411-e9vvjv8w 52 2 , , , cord-254411-e9vvjv8w 52 3 ATP ATP NNP cord-254411-e9vvjv8w 52 4 - - HYPH cord-254411-e9vvjv8w 52 5 depletion depletion NN cord-254411-e9vvjv8w 52 6 can can MD cord-254411-e9vvjv8w 52 7 potentially potentially RB cord-254411-e9vvjv8w 52 8 enhance enhance VB cord-254411-e9vvjv8w 52 9 profound profound JJ cord-254411-e9vvjv8w 52 10 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 52 11 secretion secretion NN cord-254411-e9vvjv8w 52 12 . . . cord-254411-e9vvjv8w 53 1 Secondly secondly RB cord-254411-e9vvjv8w 53 2 , , , cord-254411-e9vvjv8w 53 3 ATP ATP NNP cord-254411-e9vvjv8w 53 4 - - HYPH cord-254411-e9vvjv8w 53 5 depletion depletion NN cord-254411-e9vvjv8w 53 6 can can MD cord-254411-e9vvjv8w 53 7 potentially potentially RB cord-254411-e9vvjv8w 53 8 prone prone JJ cord-254411-e9vvjv8w 53 9 the the DT cord-254411-e9vvjv8w 53 10 recruited recruit VBN cord-254411-e9vvjv8w 53 11 immune immune JJ cord-254411-e9vvjv8w 53 12 cells cell NNS cord-254411-e9vvjv8w 53 13 to to IN cord-254411-e9vvjv8w 53 14 earlier early JJR cord-254411-e9vvjv8w 53 15 exhaustion exhaustion NN cord-254411-e9vvjv8w 53 16 against against IN cord-254411-e9vvjv8w 53 17 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 53 18 . . . cord-254411-e9vvjv8w 54 1 Therefore therefore RB cord-254411-e9vvjv8w 54 2 , , , cord-254411-e9vvjv8w 54 3 one one PRP cord-254411-e9vvjv8w 54 4 may may MD cord-254411-e9vvjv8w 54 5 conclude conclude VB cord-254411-e9vvjv8w 54 6 that that IN cord-254411-e9vvjv8w 54 7 ATP ATP NNP cord-254411-e9vvjv8w 54 8 - - HYPH cord-254411-e9vvjv8w 54 9 repletion repletion NN cord-254411-e9vvjv8w 54 10 can can MD cord-254411-e9vvjv8w 54 11 prevent prevent VB cord-254411-e9vvjv8w 54 12 the the DT cord-254411-e9vvjv8w 54 13 so so RB cord-254411-e9vvjv8w 54 14 - - HYPH cord-254411-e9vvjv8w 54 15 called call VBN cord-254411-e9vvjv8w 54 16 " " `` cord-254411-e9vvjv8w 54 17 cytokine cytokine NN cord-254411-e9vvjv8w 54 18 storm storm NN cord-254411-e9vvjv8w 54 19 " " '' cord-254411-e9vvjv8w 54 20 and and CC cord-254411-e9vvjv8w 54 21 improve improve VB cord-254411-e9vvjv8w 54 22 the the DT cord-254411-e9vvjv8w 54 23 cellular cellular JJ cord-254411-e9vvjv8w 54 24 energy energy NN cord-254411-e9vvjv8w 54 25 to to TO cord-254411-e9vvjv8w 54 26 better better RB cord-254411-e9vvjv8w 54 27 counteract counteract VB cord-254411-e9vvjv8w 54 28 with with IN cord-254411-e9vvjv8w 54 29 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 54 30 . . . cord-254411-e9vvjv8w 55 1 Channappanavar Channappanavar NNP cord-254411-e9vvjv8w 55 2 et et NNP cord-254411-e9vvjv8w 55 3 al al NNP cord-254411-e9vvjv8w 55 4 . . NNP cord-254411-e9vvjv8w 55 5 demonstrated demonstrate VBD cord-254411-e9vvjv8w 55 6 that that IN cord-254411-e9vvjv8w 55 7 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 55 8 can can MD cord-254411-e9vvjv8w 55 9 promote promote VB cord-254411-e9vvjv8w 55 10 T T NNP cord-254411-e9vvjv8w 55 11 - - HYPH cord-254411-e9vvjv8w 55 12 cells cell NNS cord-254411-e9vvjv8w 55 13 to to IN cord-254411-e9vvjv8w 55 14 IFN IFN NNP cord-254411-e9vvjv8w 55 15 - - HYPH cord-254411-e9vvjv8w 55 16 induced induce VBN cord-254411-e9vvjv8w 55 17 apoptosis apoptosis NN cord-254411-e9vvjv8w 55 18 , , , cord-254411-e9vvjv8w 55 19 resulting result VBG cord-254411-e9vvjv8w 55 20 in in IN cord-254411-e9vvjv8w 55 21 reduced reduce VBN cord-254411-e9vvjv8w 55 22 numbers number NNS cord-254411-e9vvjv8w 55 23 of of IN cord-254411-e9vvjv8w 55 24 virus virus NN cord-254411-e9vvjv8w 55 25 - - HYPH cord-254411-e9vvjv8w 55 26 specific specific JJ cord-254411-e9vvjv8w 55 27 CD8 CD8 NNP cord-254411-e9vvjv8w 55 28 and and CC cord-254411-e9vvjv8w 55 29 CD4 CD4 NNP cord-254411-e9vvjv8w 55 30 T T NNP cord-254411-e9vvjv8w 55 31 - - HYPH cord-254411-e9vvjv8w 55 32 cells cell NNS cord-254411-e9vvjv8w 55 33 ( ( -LRB- cord-254411-e9vvjv8w 55 34 5 5 CD cord-254411-e9vvjv8w 55 35 ) ) -RRB- cord-254411-e9vvjv8w 55 36 . . . cord-254411-e9vvjv8w 56 1 From from IN cord-254411-e9vvjv8w 56 2 the the DT cord-254411-e9vvjv8w 56 3 perspective perspective NN cord-254411-e9vvjv8w 56 4 of of IN cord-254411-e9vvjv8w 56 5 cellular cellular JJ cord-254411-e9vvjv8w 56 6 energy energy NN cord-254411-e9vvjv8w 56 7 , , , cord-254411-e9vvjv8w 56 8 this this DT cord-254411-e9vvjv8w 56 9 process process NN cord-254411-e9vvjv8w 56 10 potentially potentially RB cord-254411-e9vvjv8w 56 11 occurs occur VBZ cord-254411-e9vvjv8w 56 12 through through IN cord-254411-e9vvjv8w 56 13 IFN IFN NNP cord-254411-e9vvjv8w 56 14 - - HYPH cord-254411-e9vvjv8w 56 15 mediated mediate VBN cord-254411-e9vvjv8w 56 16 T t NN cord-254411-e9vvjv8w 56 17 - - HYPH cord-254411-e9vvjv8w 56 18 cell cell NN cord-254411-e9vvjv8w 56 19 activation activation NN cord-254411-e9vvjv8w 56 20 that that WDT cord-254411-e9vvjv8w 56 21 results result VBZ cord-254411-e9vvjv8w 56 22 in in IN cord-254411-e9vvjv8w 56 23 c c NNP cord-254411-e9vvjv8w 56 24 - - HYPH cord-254411-e9vvjv8w 56 25 ATP ATP NNP cord-254411-e9vvjv8w 56 26 depletion depletion NN cord-254411-e9vvjv8w 56 27 . . . cord-254411-e9vvjv8w 57 1 In in IN cord-254411-e9vvjv8w 57 2 line line NN cord-254411-e9vvjv8w 57 3 with with IN cord-254411-e9vvjv8w 57 4 this this DT cord-254411-e9vvjv8w 57 5 hypothesis hypothesis NN cord-254411-e9vvjv8w 57 6 , , , cord-254411-e9vvjv8w 57 7 Perl Perl NNP cord-254411-e9vvjv8w 57 8 et et NNP cord-254411-e9vvjv8w 57 9 al al NNP cord-254411-e9vvjv8w 57 10 . . NNP cord-254411-e9vvjv8w 57 11 have have VBP cord-254411-e9vvjv8w 57 12 shown show VBN cord-254411-e9vvjv8w 57 13 that that IN cord-254411-e9vvjv8w 57 14 following follow VBG cord-254411-e9vvjv8w 57 15 IFN IFN NNP cord-254411-e9vvjv8w 57 16 - - HYPH cord-254411-e9vvjv8w 57 17 γ γ NN cord-254411-e9vvjv8w 57 18 stimulation stimulation NN cord-254411-e9vvjv8w 57 19 , , , cord-254411-e9vvjv8w 57 20 mitochondrial mitochondrial JJ cord-254411-e9vvjv8w 57 21 hyperpolarization hyperpolarization NN cord-254411-e9vvjv8w 57 22 and and CC cord-254411-e9vvjv8w 57 23 ATP ATP NNP cord-254411-e9vvjv8w 57 24 depletion depletion NN cord-254411-e9vvjv8w 57 25 occurs occur VBZ cord-254411-e9vvjv8w 57 26 in in IN cord-254411-e9vvjv8w 57 27 T T NNP cord-254411-e9vvjv8w 57 28 - - HYPH cord-254411-e9vvjv8w 57 29 cells cell NNS cord-254411-e9vvjv8w 57 30 that that WDT cord-254411-e9vvjv8w 57 31 results result VBZ cord-254411-e9vvjv8w 57 32 in in IN cord-254411-e9vvjv8w 57 33 apoptosis apoptosis NN cord-254411-e9vvjv8w 57 34 ( ( -LRB- cord-254411-e9vvjv8w 57 35 10 10 CD cord-254411-e9vvjv8w 57 36 ) ) -RRB- cord-254411-e9vvjv8w 57 37 . . . cord-254411-e9vvjv8w 58 1 Therefore therefore RB cord-254411-e9vvjv8w 58 2 , , , cord-254411-e9vvjv8w 58 3 ATP ATP NNP cord-254411-e9vvjv8w 58 4 - - HYPH cord-254411-e9vvjv8w 58 5 repletion repletion NN cord-254411-e9vvjv8w 58 6 can can MD cord-254411-e9vvjv8w 58 7 potentially potentially RB cord-254411-e9vvjv8w 58 8 prevent prevent VB cord-254411-e9vvjv8w 58 9 T t NN cord-254411-e9vvjv8w 58 10 - - HYPH cord-254411-e9vvjv8w 58 11 cell cell NN cord-254411-e9vvjv8w 58 12 apoptosis apoptosis NN cord-254411-e9vvjv8w 58 13 following follow VBG cord-254411-e9vvjv8w 58 14 " " `` cord-254411-e9vvjv8w 58 15 cytokine cytokine NN cord-254411-e9vvjv8w 58 16 storm storm NN cord-254411-e9vvjv8w 58 17 " " '' cord-254411-e9vvjv8w 58 18 . . . cord-254411-e9vvjv8w 59 1 In in IN cord-254411-e9vvjv8w 59 2 the the DT cord-254411-e9vvjv8w 59 3 following following JJ cord-254411-e9vvjv8w 59 4 section section NN cord-254411-e9vvjv8w 59 5 , , , cord-254411-e9vvjv8w 59 6 we -PRON- PRP cord-254411-e9vvjv8w 59 7 use use VBP cord-254411-e9vvjv8w 59 8 our -PRON- PRP$ cord-254411-e9vvjv8w 59 9 hypothesis hypothesis NN cord-254411-e9vvjv8w 59 10 to to TO cord-254411-e9vvjv8w 59 11 demonstrate demonstrate VB cord-254411-e9vvjv8w 59 12 why why WRB cord-254411-e9vvjv8w 59 13 specific specific JJ cord-254411-e9vvjv8w 59 14 groups group NNS cord-254411-e9vvjv8w 59 15 of of IN cord-254411-e9vvjv8w 59 16 people people NNS cord-254411-e9vvjv8w 59 17 are be VBP cord-254411-e9vvjv8w 59 18 more more RBR cord-254411-e9vvjv8w 59 19 susceptible susceptible JJ cord-254411-e9vvjv8w 59 20 to to TO cord-254411-e9vvjv8w 59 21 be be VB cord-254411-e9vvjv8w 59 22 infected infect VBN cord-254411-e9vvjv8w 59 23 with with IN cord-254411-e9vvjv8w 59 24 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 59 25 and and CC cord-254411-e9vvjv8w 59 26 why why WRB cord-254411-e9vvjv8w 59 27 they -PRON- PRP cord-254411-e9vvjv8w 59 28 have have VBP cord-254411-e9vvjv8w 59 29 a a DT cord-254411-e9vvjv8w 59 30 worse bad JJR cord-254411-e9vvjv8w 59 31 prognosis prognosis NN cord-254411-e9vvjv8w 59 32 . . . cord-254411-e9vvjv8w 60 1 The the DT cord-254411-e9vvjv8w 60 2 case case NN cord-254411-e9vvjv8w 60 3 - - HYPH cord-254411-e9vvjv8w 60 4 fatality fatality NN cord-254411-e9vvjv8w 60 5 rate rate NN cord-254411-e9vvjv8w 60 6 of of IN cord-254411-e9vvjv8w 60 7 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 60 8 is be VBZ cord-254411-e9vvjv8w 60 9 the the DT cord-254411-e9vvjv8w 60 10 highest high JJS cord-254411-e9vvjv8w 60 11 ( ( -LRB- cord-254411-e9vvjv8w 60 12 14.8 14.8 CD cord-254411-e9vvjv8w 60 13 % % NN cord-254411-e9vvjv8w 60 14 ) ) -RRB- cord-254411-e9vvjv8w 60 15 in in IN cord-254411-e9vvjv8w 60 16 elderly elderly JJ cord-254411-e9vvjv8w 60 17 - - HYPH cord-254411-e9vvjv8w 60 18 population population NN cord-254411-e9vvjv8w 60 19 . . . cord-254411-e9vvjv8w 61 1 In in IN cord-254411-e9vvjv8w 61 2 contrast contrast NN cord-254411-e9vvjv8w 61 3 , , , cord-254411-e9vvjv8w 61 4 children child NNS cord-254411-e9vvjv8w 61 5 have have VBP cord-254411-e9vvjv8w 61 6 the the DT cord-254411-e9vvjv8w 61 7 lowest low JJS cord-254411-e9vvjv8w 61 8 risk risk NN cord-254411-e9vvjv8w 61 9 for for IN cord-254411-e9vvjv8w 61 10 both both DT cord-254411-e9vvjv8w 61 11 infection infection NN cord-254411-e9vvjv8w 61 12 and and CC cord-254411-e9vvjv8w 61 13 mortality mortality NN cord-254411-e9vvjv8w 61 14 rates rate NNS cord-254411-e9vvjv8w 61 15 ( ( -LRB- cord-254411-e9vvjv8w 61 16 11 11 CD cord-254411-e9vvjv8w 61 17 ) ) -RRB- cord-254411-e9vvjv8w 61 18 . . . cord-254411-e9vvjv8w 62 1 This this DT cord-254411-e9vvjv8w 62 2 difference difference NN cord-254411-e9vvjv8w 62 3 can can MD cord-254411-e9vvjv8w 62 4 be be VB cord-254411-e9vvjv8w 62 5 demonstrated demonstrate VBN cord-254411-e9vvjv8w 62 6 from from IN cord-254411-e9vvjv8w 62 7 the the DT cord-254411-e9vvjv8w 62 8 cellular cellular JJ cord-254411-e9vvjv8w 62 9 energy energy NN cord-254411-e9vvjv8w 62 10 concept concept NN cord-254411-e9vvjv8w 62 11 . . . cord-254411-e9vvjv8w 63 1 Aging age VBG cord-254411-e9vvjv8w 63 2 may may MD cord-254411-e9vvjv8w 63 3 potentially potentially RB cord-254411-e9vvjv8w 63 4 attenuate attenuate VB cord-254411-e9vvjv8w 63 5 the the DT cord-254411-e9vvjv8w 63 6 respiratory respiratory JJ cord-254411-e9vvjv8w 63 7 capacity capacity NN cord-254411-e9vvjv8w 63 8 of of IN cord-254411-e9vvjv8w 63 9 mitochondria mitochondrion NNS cord-254411-e9vvjv8w 63 10 . . . cord-254411-e9vvjv8w 64 1 This this DT cord-254411-e9vvjv8w 64 2 condition condition NN cord-254411-e9vvjv8w 64 3 may may MD cord-254411-e9vvjv8w 64 4 be be VB cord-254411-e9vvjv8w 64 5 either either CC cord-254411-e9vvjv8w 64 6 due due IN cord-254411-e9vvjv8w 64 7 to to IN cord-254411-e9vvjv8w 64 8 impairment impairment NN cord-254411-e9vvjv8w 64 9 of of IN cord-254411-e9vvjv8w 64 10 peroxisome peroxisome NN cord-254411-e9vvjv8w 64 11 proliferator proliferator NN cord-254411-e9vvjv8w 64 12 - - HYPH cord-254411-e9vvjv8w 64 13 activated activate VBN cord-254411-e9vvjv8w 64 14 receptor receptor NN cord-254411-e9vvjv8w 64 15 - - HYPH cord-254411-e9vvjv8w 64 16 gamma gamma NN cord-254411-e9vvjv8w 64 17 coactivator-1α coactivator-1α NNP cord-254411-e9vvjv8w 64 18 ( ( -LRB- cord-254411-e9vvjv8w 64 19 PGC-1α PGC-1α NNP cord-254411-e9vvjv8w 64 20 ) ) -RRB- cord-254411-e9vvjv8w 64 21 or or CC cord-254411-e9vvjv8w 64 22 age age NN cord-254411-e9vvjv8w 64 23 - - HYPH cord-254411-e9vvjv8w 64 24 related relate VBN cord-254411-e9vvjv8w 64 25 accumulation accumulation NN cord-254411-e9vvjv8w 64 26 of of IN cord-254411-e9vvjv8w 64 27 mitochondrial mitochondrial JJ cord-254411-e9vvjv8w 64 28 DNA dna NN cord-254411-e9vvjv8w 64 29 mutations mutation NNS cord-254411-e9vvjv8w 64 30 ( ( -LRB- cord-254411-e9vvjv8w 64 31 12 12 CD cord-254411-e9vvjv8w 64 32 ) ) -RRB- cord-254411-e9vvjv8w 64 33 . . . cord-254411-e9vvjv8w 65 1 Moreover moreover RB cord-254411-e9vvjv8w 65 2 , , , cord-254411-e9vvjv8w 65 3 aging age VBG cord-254411-e9vvjv8w 65 4 can can MD cord-254411-e9vvjv8w 65 5 wane wane VB cord-254411-e9vvjv8w 65 6 the the DT cord-254411-e9vvjv8w 65 7 ability ability NN cord-254411-e9vvjv8w 65 8 of of IN cord-254411-e9vvjv8w 65 9 immune immune JJ cord-254411-e9vvjv8w 65 10 cells cell NNS cord-254411-e9vvjv8w 65 11 to to TO cord-254411-e9vvjv8w 65 12 secrete secrete VB cord-254411-e9vvjv8w 65 13 IFN IFN NNP cord-254411-e9vvjv8w 65 14 following follow VBG cord-254411-e9vvjv8w 65 15 viral viral JJ cord-254411-e9vvjv8w 65 16 infection infection NN cord-254411-e9vvjv8w 65 17 ( ( -LRB- cord-254411-e9vvjv8w 65 18 13 13 CD cord-254411-e9vvjv8w 65 19 ) ) -RRB- cord-254411-e9vvjv8w 65 20 . . . cord-254411-e9vvjv8w 66 1 As as IN cord-254411-e9vvjv8w 66 2 noted note VBN cord-254411-e9vvjv8w 66 3 earlier early RBR cord-254411-e9vvjv8w 66 4 , , , cord-254411-e9vvjv8w 66 5 this this DT cord-254411-e9vvjv8w 66 6 may may MD cord-254411-e9vvjv8w 66 7 be be VB cord-254411-e9vvjv8w 66 8 due due JJ cord-254411-e9vvjv8w 66 9 to to IN cord-254411-e9vvjv8w 66 10 ATP ATP NNP cord-254411-e9vvjv8w 66 11 - - HYPH cord-254411-e9vvjv8w 66 12 depletion depletion NN cord-254411-e9vvjv8w 66 13 . . . cord-254411-e9vvjv8w 67 1 Therefore therefore RB cord-254411-e9vvjv8w 67 2 , , , cord-254411-e9vvjv8w 67 3 one one PRP cord-254411-e9vvjv8w 67 4 can can MD cord-254411-e9vvjv8w 67 5 conclude conclude VB cord-254411-e9vvjv8w 67 6 that that IN cord-254411-e9vvjv8w 67 7 a a DT cord-254411-e9vvjv8w 67 8 gradual gradual JJ cord-254411-e9vvjv8w 67 9 decline decline NN cord-254411-e9vvjv8w 67 10 in in IN cord-254411-e9vvjv8w 67 11 prognosis prognosis NN cord-254411-e9vvjv8w 67 12 with with IN cord-254411-e9vvjv8w 67 13 age age NN cord-254411-e9vvjv8w 67 14 may may MD cord-254411-e9vvjv8w 67 15 rely rely VB cord-254411-e9vvjv8w 67 16 on on IN cord-254411-e9vvjv8w 67 17 a a DT cord-254411-e9vvjv8w 67 18 gradual gradual JJ cord-254411-e9vvjv8w 67 19 decrease decrease NN cord-254411-e9vvjv8w 67 20 in in IN cord-254411-e9vvjv8w 67 21 c c NN cord-254411-e9vvjv8w 67 22 - - HYPH cord-254411-e9vvjv8w 67 23 ATP ATP NNP cord-254411-e9vvjv8w 67 24 . . . cord-254411-e9vvjv8w 68 1 The the DT cord-254411-e9vvjv8w 68 2 risk risk NN cord-254411-e9vvjv8w 68 3 of of IN cord-254411-e9vvjv8w 68 4 long long RB cord-254411-e9vvjv8w 68 5 - - HYPH cord-254411-e9vvjv8w 68 6 lasting last VBG cord-254411-e9vvjv8w 68 7 and and CC cord-254411-e9vvjv8w 68 8 serious serious JJ cord-254411-e9vvjv8w 68 9 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 68 10 infection infection NN cord-254411-e9vvjv8w 68 11 is be VBZ cord-254411-e9vvjv8w 68 12 more more JJR cord-254411-e9vvjv8w 68 13 among among IN cord-254411-e9vvjv8w 68 14 tobacco tobacco NN cord-254411-e9vvjv8w 68 15 smokers smoker NNS cord-254411-e9vvjv8w 68 16 . . . cord-254411-e9vvjv8w 69 1 Apart apart RB cord-254411-e9vvjv8w 69 2 from from IN cord-254411-e9vvjv8w 69 3 a a DT cord-254411-e9vvjv8w 69 4 direct direct JJ cord-254411-e9vvjv8w 69 5 effect effect NN cord-254411-e9vvjv8w 69 6 on on IN cord-254411-e9vvjv8w 69 7 lung lung NN cord-254411-e9vvjv8w 69 8 parenchyma parenchyma NNS cord-254411-e9vvjv8w 69 9 and and CC cord-254411-e9vvjv8w 69 10 a a DT cord-254411-e9vvjv8w 69 11 decrease decrease NN cord-254411-e9vvjv8w 69 12 in in IN cord-254411-e9vvjv8w 69 13 pulmonary pulmonary JJ cord-254411-e9vvjv8w 69 14 capacity capacity NN cord-254411-e9vvjv8w 69 15 , , , cord-254411-e9vvjv8w 69 16 tobacco tobacco NN cord-254411-e9vvjv8w 69 17 smoke smoke NN cord-254411-e9vvjv8w 69 18 can can MD cord-254411-e9vvjv8w 69 19 potentially potentially RB cord-254411-e9vvjv8w 69 20 induce induce VB cord-254411-e9vvjv8w 69 21 immune immune JJ cord-254411-e9vvjv8w 69 22 dysfunction dysfunction NN cord-254411-e9vvjv8w 69 23 through through IN cord-254411-e9vvjv8w 69 24 a a DT cord-254411-e9vvjv8w 69 25 decrease decrease NN cord-254411-e9vvjv8w 69 26 in in IN cord-254411-e9vvjv8w 69 27 ATP ATP NNP cord-254411-e9vvjv8w 69 28 content content NN cord-254411-e9vvjv8w 69 29 of of IN cord-254411-e9vvjv8w 69 30 immune immune JJ cord-254411-e9vvjv8w 69 31 cells cell NNS cord-254411-e9vvjv8w 69 32 . . . cord-254411-e9vvjv8w 70 1 This this DT cord-254411-e9vvjv8w 70 2 can can MD cord-254411-e9vvjv8w 70 3 be be VB cord-254411-e9vvjv8w 70 4 due due JJ cord-254411-e9vvjv8w 70 5 to to IN cord-254411-e9vvjv8w 70 6 nicotine nicotine NN cord-254411-e9vvjv8w 70 7 - - HYPH cord-254411-e9vvjv8w 70 8 induced induce VBN cord-254411-e9vvjv8w 70 9 mitochondrial mitochondrial JJ cord-254411-e9vvjv8w 70 10 dysfunction dysfunction NN cord-254411-e9vvjv8w 70 11 ( ( -LRB- cord-254411-e9vvjv8w 70 12 14 14 CD cord-254411-e9vvjv8w 70 13 ) ) -RRB- cord-254411-e9vvjv8w 70 14 . . . cord-254411-e9vvjv8w 71 1 The the DT cord-254411-e9vvjv8w 71 2 resultant resultant JJ cord-254411-e9vvjv8w 71 3 ATP ATP NNP cord-254411-e9vvjv8w 71 4 - - HYPH cord-254411-e9vvjv8w 71 5 depletion depletion NN cord-254411-e9vvjv8w 71 6 increase increase NN cord-254411-e9vvjv8w 71 7 the the DT cord-254411-e9vvjv8w 71 8 risk risk NN cord-254411-e9vvjv8w 71 9 of of IN cord-254411-e9vvjv8w 71 10 immune immune JJ cord-254411-e9vvjv8w 71 11 dysregulation dysregulation NN cord-254411-e9vvjv8w 71 12 by by IN cord-254411-e9vvjv8w 71 13 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 72 1 ( ( -LRB- cord-254411-e9vvjv8w 72 2 refer refer VB cord-254411-e9vvjv8w 72 3 to to IN cord-254411-e9vvjv8w 72 4 the the DT cord-254411-e9vvjv8w 72 5 aforementioned aforementioned JJ cord-254411-e9vvjv8w 72 6 defensive defensive JJ cord-254411-e9vvjv8w 72 7 mechanisms mechanism NNS cord-254411-e9vvjv8w 72 8 of of IN cord-254411-e9vvjv8w 72 9 COVID-19 covid-19 CD cord-254411-e9vvjv8w 72 10 ) ) -RRB- cord-254411-e9vvjv8w 72 11 . . . cord-254411-e9vvjv8w 73 1 While while IN cord-254411-e9vvjv8w 73 2 men man NNS cord-254411-e9vvjv8w 73 3 and and CC cord-254411-e9vvjv8w 73 4 women woman NNS cord-254411-e9vvjv8w 73 5 have have VBP cord-254411-e9vvjv8w 73 6 the the DT cord-254411-e9vvjv8w 73 7 same same JJ cord-254411-e9vvjv8w 73 8 susceptibility susceptibility NN cord-254411-e9vvjv8w 73 9 to to IN cord-254411-e9vvjv8w 73 10 COVID-19 covid-19 VB cord-254411-e9vvjv8w 73 11 , , , cord-254411-e9vvjv8w 73 12 men man NNS cord-254411-e9vvjv8w 73 13 are be VBP cord-254411-e9vvjv8w 73 14 more more RBR cord-254411-e9vvjv8w 73 15 prone prone JJ cord-254411-e9vvjv8w 73 16 to to IN cord-254411-e9vvjv8w 73 17 higher high JJR cord-254411-e9vvjv8w 73 18 morbidity morbidity NN cord-254411-e9vvjv8w 73 19 and and CC cord-254411-e9vvjv8w 73 20 mortality mortality NN cord-254411-e9vvjv8w 73 21 independent independent JJ cord-254411-e9vvjv8w 73 22 of of IN cord-254411-e9vvjv8w 73 23 age age NN cord-254411-e9vvjv8w 73 24 ( ( -LRB- cord-254411-e9vvjv8w 73 25 15 15 CD cord-254411-e9vvjv8w 73 26 ) ) -RRB- cord-254411-e9vvjv8w 73 27 . . . cord-254411-e9vvjv8w 74 1 This this DT cord-254411-e9vvjv8w 74 2 difference difference NN cord-254411-e9vvjv8w 74 3 can can MD cord-254411-e9vvjv8w 74 4 be be VB cord-254411-e9vvjv8w 74 5 justified justify VBN cord-254411-e9vvjv8w 74 6 by by IN cord-254411-e9vvjv8w 74 7 the the DT cord-254411-e9vvjv8w 74 8 cell cell NN cord-254411-e9vvjv8w 74 9 energy energy NN cord-254411-e9vvjv8w 74 10 hypothesis hypothesis NN cord-254411-e9vvjv8w 74 11 . . . cord-254411-e9vvjv8w 75 1 Estrogens estrogen NNS cord-254411-e9vvjv8w 75 2 ( ( -LRB- cord-254411-e9vvjv8w 75 3 as as IN cord-254411-e9vvjv8w 75 4 the the DT cord-254411-e9vvjv8w 75 5 main main JJ cord-254411-e9vvjv8w 75 6 sex sex NN cord-254411-e9vvjv8w 75 7 steroid steroid NN cord-254411-e9vvjv8w 75 8 of of IN cord-254411-e9vvjv8w 75 9 females female NNS cord-254411-e9vvjv8w 75 10 ) ) -RRB- cord-254411-e9vvjv8w 75 11 are be VBP cord-254411-e9vvjv8w 75 12 potent potent JJ cord-254411-e9vvjv8w 75 13 stabilizers stabilizer NNS cord-254411-e9vvjv8w 75 14 of of IN cord-254411-e9vvjv8w 75 15 ATP ATP NNP cord-254411-e9vvjv8w 75 16 production production NN cord-254411-e9vvjv8w 75 17 during during IN cord-254411-e9vvjv8w 75 18 oxidative oxidative JJ cord-254411-e9vvjv8w 75 19 stress stress NN cord-254411-e9vvjv8w 75 20 ( ( -LRB- cord-254411-e9vvjv8w 75 21 e.g. e.g. RB cord-254411-e9vvjv8w 75 22 during during IN cord-254411-e9vvjv8w 75 23 COVID-19-induced covid-19-induced JJ cord-254411-e9vvjv8w 75 24 inflammation inflammation NN cord-254411-e9vvjv8w 75 25 ) ) -RRB- cord-254411-e9vvjv8w 75 26 ( ( -LRB- cord-254411-e9vvjv8w 75 27 16 16 CD cord-254411-e9vvjv8w 75 28 ) ) -RRB- cord-254411-e9vvjv8w 75 29 . . . cord-254411-e9vvjv8w 76 1 Therefore therefore RB cord-254411-e9vvjv8w 76 2 , , , cord-254411-e9vvjv8w 76 3 it -PRON- PRP cord-254411-e9vvjv8w 76 4 seems seem VBZ cord-254411-e9vvjv8w 76 5 that that IN cord-254411-e9vvjv8w 76 6 women woman NNS cord-254411-e9vvjv8w 76 7 are be VBP cord-254411-e9vvjv8w 76 8 more more RBR cord-254411-e9vvjv8w 76 9 capable capable JJ cord-254411-e9vvjv8w 76 10 to to TO cord-254411-e9vvjv8w 76 11 maintain maintain VB cord-254411-e9vvjv8w 76 12 the the DT cord-254411-e9vvjv8w 76 13 c c NNP cord-254411-e9vvjv8w 76 14 - - HYPH cord-254411-e9vvjv8w 76 15 ATP ATP NNP cord-254411-e9vvjv8w 76 16 of of IN cord-254411-e9vvjv8w 76 17 their -PRON- PRP$ cord-254411-e9vvjv8w 76 18 immune immune JJ cord-254411-e9vvjv8w 76 19 cells cell NNS cord-254411-e9vvjv8w 76 20 during during IN cord-254411-e9vvjv8w 76 21 the the DT cord-254411-e9vvjv8w 76 22 immune immune JJ cord-254411-e9vvjv8w 76 23 response response NN cord-254411-e9vvjv8w 76 24 to to IN cord-254411-e9vvjv8w 76 25 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 76 26 . . . cord-254411-e9vvjv8w 77 1 With with IN cord-254411-e9vvjv8w 77 2 this this DT cord-254411-e9vvjv8w 77 3 notion notion NN cord-254411-e9vvjv8w 77 4 in in IN cord-254411-e9vvjv8w 77 5 mind mind NN cord-254411-e9vvjv8w 77 6 , , , cord-254411-e9vvjv8w 77 7 men man NNS cord-254411-e9vvjv8w 77 8 are be VBP cord-254411-e9vvjv8w 77 9 more more RBR cord-254411-e9vvjv8w 77 10 susceptible susceptible JJ cord-254411-e9vvjv8w 77 11 to to IN cord-254411-e9vvjv8w 77 12 immune immune JJ cord-254411-e9vvjv8w 77 13 dysregulation dysregulation NN cord-254411-e9vvjv8w 77 14 following follow VBG cord-254411-e9vvjv8w 77 15 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 77 16 infection infection NN cord-254411-e9vvjv8w 77 17 . . . cord-254411-e9vvjv8w 78 1 Recent recent JJ cord-254411-e9vvjv8w 78 2 reports report NNS cord-254411-e9vvjv8w 78 3 have have VBP cord-254411-e9vvjv8w 78 4 highlighted highlight VBN cord-254411-e9vvjv8w 78 5 some some DT cord-254411-e9vvjv8w 78 6 chronic chronic JJ cord-254411-e9vvjv8w 78 7 illnesses illness NNS cord-254411-e9vvjv8w 78 8 that that WDT cord-254411-e9vvjv8w 78 9 increase increase VBP cord-254411-e9vvjv8w 78 10 the the DT cord-254411-e9vvjv8w 78 11 mortality mortality NN cord-254411-e9vvjv8w 78 12 of of IN cord-254411-e9vvjv8w 78 13 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 78 14 . . . cord-254411-e9vvjv8w 79 1 They -PRON- PRP cord-254411-e9vvjv8w 79 2 include include VBP cord-254411-e9vvjv8w 79 3 underlying underlying JJ cord-254411-e9vvjv8w 79 4 conditions condition NNS cord-254411-e9vvjv8w 79 5 such such JJ cord-254411-e9vvjv8w 79 6 as as IN cord-254411-e9vvjv8w 79 7 hypertension hypertension NN cord-254411-e9vvjv8w 79 8 , , , cord-254411-e9vvjv8w 79 9 diabetes diabetes NN cord-254411-e9vvjv8w 79 10 , , , cord-254411-e9vvjv8w 79 11 coronary coronary JJ cord-254411-e9vvjv8w 79 12 heart heart NN cord-254411-e9vvjv8w 79 13 disease disease NN cord-254411-e9vvjv8w 79 14 , , , cord-254411-e9vvjv8w 79 15 chronic chronic JJ cord-254411-e9vvjv8w 79 16 obstructive obstructive JJ cord-254411-e9vvjv8w 79 17 lung lung NN cord-254411-e9vvjv8w 79 18 disease disease NN cord-254411-e9vvjv8w 79 19 , , , cord-254411-e9vvjv8w 79 20 cancer cancer NN cord-254411-e9vvjv8w 79 21 , , , cord-254411-e9vvjv8w 79 22 and and CC cord-254411-e9vvjv8w 79 23 chronic chronic JJ cord-254411-e9vvjv8w 79 24 kidney kidney NN cord-254411-e9vvjv8w 79 25 disease disease NN cord-254411-e9vvjv8w 79 26 ( ( -LRB- cord-254411-e9vvjv8w 79 27 17 17 CD cord-254411-e9vvjv8w 79 28 ) ) -RRB- cord-254411-e9vvjv8w 79 29 . . . cord-254411-e9vvjv8w 80 1 Apart apart RB cord-254411-e9vvjv8w 80 2 from from IN cord-254411-e9vvjv8w 80 3 a a DT cord-254411-e9vvjv8w 80 4 decline decline NN cord-254411-e9vvjv8w 80 5 in in IN cord-254411-e9vvjv8w 80 6 cardiovascular cardiovascular JJ cord-254411-e9vvjv8w 80 7 reserve reserve NN cord-254411-e9vvjv8w 80 8 , , , cord-254411-e9vvjv8w 80 9 the the DT cord-254411-e9vvjv8w 80 10 effect effect NN cord-254411-e9vvjv8w 80 11 of of IN cord-254411-e9vvjv8w 80 12 these these DT cord-254411-e9vvjv8w 80 13 chronic chronic JJ cord-254411-e9vvjv8w 80 14 conditions condition NNS cord-254411-e9vvjv8w 80 15 on on IN cord-254411-e9vvjv8w 80 16 the the DT cord-254411-e9vvjv8w 80 17 prognosis prognosis NN cord-254411-e9vvjv8w 80 18 of of IN cord-254411-e9vvjv8w 80 19 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 80 20 can can MD cord-254411-e9vvjv8w 80 21 be be VB cord-254411-e9vvjv8w 80 22 justified justify VBN cord-254411-e9vvjv8w 80 23 by by IN cord-254411-e9vvjv8w 80 24 our -PRON- PRP$ cord-254411-e9vvjv8w 80 25 hypothesis hypothesis NN cord-254411-e9vvjv8w 80 26 . . . cord-254411-e9vvjv8w 81 1 Human human JJ cord-254411-e9vvjv8w 81 2 cells cell NNS cord-254411-e9vvjv8w 81 3 need need VBP cord-254411-e9vvjv8w 81 4 nutrients nutrient NNS cord-254411-e9vvjv8w 81 5 ( ( -LRB- cord-254411-e9vvjv8w 81 6 including include VBG cord-254411-e9vvjv8w 81 7 glucose glucose NN cord-254411-e9vvjv8w 81 8 , , , cord-254411-e9vvjv8w 81 9 free free JJ cord-254411-e9vvjv8w 81 10 fatty fatty JJ cord-254411-e9vvjv8w 81 11 acids acid NNS cord-254411-e9vvjv8w 81 12 , , , cord-254411-e9vvjv8w 81 13 essential essential JJ cord-254411-e9vvjv8w 81 14 amino amino NN cord-254411-e9vvjv8w 81 15 acids acid NNS cord-254411-e9vvjv8w 81 16 , , , cord-254411-e9vvjv8w 81 17 and and CC cord-254411-e9vvjv8w 81 18 O o UH cord-254411-e9vvjv8w 81 19 2 2 CD cord-254411-e9vvjv8w 81 20 ) ) -RRB- cord-254411-e9vvjv8w 81 21 to to TO cord-254411-e9vvjv8w 81 22 maintain maintain VB cord-254411-e9vvjv8w 81 23 their -PRON- PRP$ cord-254411-e9vvjv8w 81 24 c c NN cord-254411-e9vvjv8w 81 25 - - HYPH cord-254411-e9vvjv8w 81 26 ATP ATP NNP cord-254411-e9vvjv8w 81 27 level level NN cord-254411-e9vvjv8w 81 28 . . . cord-254411-e9vvjv8w 82 1 The the DT cord-254411-e9vvjv8w 82 2 aforementioned aforementioned JJ cord-254411-e9vvjv8w 82 3 illnesses illness NNS cord-254411-e9vvjv8w 82 4 impede impede VBP cord-254411-e9vvjv8w 82 5 the the DT cord-254411-e9vvjv8w 82 6 regular regular JJ cord-254411-e9vvjv8w 82 7 distribution distribution NN cord-254411-e9vvjv8w 82 8 of of IN cord-254411-e9vvjv8w 82 9 the the DT cord-254411-e9vvjv8w 82 10 nutrients nutrient NNS cord-254411-e9vvjv8w 82 11 secondary secondary JJ cord-254411-e9vvjv8w 82 12 to to IN cord-254411-e9vvjv8w 82 13 compromising compromise VBG cord-254411-e9vvjv8w 82 14 the the DT cord-254411-e9vvjv8w 82 15 function function NN cord-254411-e9vvjv8w 82 16 and and CC cord-254411-e9vvjv8w 82 17 structure structure NN cord-254411-e9vvjv8w 82 18 of of IN cord-254411-e9vvjv8w 82 19 small small JJ cord-254411-e9vvjv8w 82 20 and and CC cord-254411-e9vvjv8w 82 21 large large JJ cord-254411-e9vvjv8w 82 22 vessels vessel NNS cord-254411-e9vvjv8w 82 23 . . . cord-254411-e9vvjv8w 83 1 Therefore therefore RB cord-254411-e9vvjv8w 83 2 , , , cord-254411-e9vvjv8w 83 3 the the DT cord-254411-e9vvjv8w 83 4 human human JJ cord-254411-e9vvjv8w 83 5 cells cell NNS cord-254411-e9vvjv8w 83 6 ( ( -LRB- cord-254411-e9vvjv8w 83 7 including include VBG cord-254411-e9vvjv8w 83 8 in in IN cord-254411-e9vvjv8w 83 9 - - HYPH cord-254411-e9vvjv8w 83 10 situ situ NN cord-254411-e9vvjv8w 83 11 immune immune JJ cord-254411-e9vvjv8w 83 12 cells cell NNS cord-254411-e9vvjv8w 83 13 ) ) -RRB- cord-254411-e9vvjv8w 83 14 confront confront VBP cord-254411-e9vvjv8w 83 15 ATP ATP NNP cord-254411-e9vvjv8w 83 16 - - HYPH cord-254411-e9vvjv8w 83 17 depletion depletion NN cord-254411-e9vvjv8w 83 18 and and CC cord-254411-e9vvjv8w 83 19 results result NNS cord-254411-e9vvjv8w 83 20 in in IN cord-254411-e9vvjv8w 83 21 further further JJ cord-254411-e9vvjv8w 83 22 immune immune JJ cord-254411-e9vvjv8w 83 23 dysregulation dysregulation NN cord-254411-e9vvjv8w 83 24 ( ( -LRB- cord-254411-e9vvjv8w 83 25 as as IN cord-254411-e9vvjv8w 83 26 mentioned mention VBN cord-254411-e9vvjv8w 83 27 above above RB cord-254411-e9vvjv8w 83 28 ) ) -RRB- cord-254411-e9vvjv8w 83 29 . . . cord-254411-e9vvjv8w 84 1 In in IN cord-254411-e9vvjv8w 84 2 light light NN cord-254411-e9vvjv8w 84 3 of of IN cord-254411-e9vvjv8w 84 4 these these DT cord-254411-e9vvjv8w 84 5 considerations consideration NNS cord-254411-e9vvjv8w 84 6 , , , cord-254411-e9vvjv8w 84 7 the the DT cord-254411-e9vvjv8w 84 8 c c NNP cord-254411-e9vvjv8w 84 9 - - HYPH cord-254411-e9vvjv8w 84 10 ATP ATP NNP cord-254411-e9vvjv8w 84 11 level level NN cord-254411-e9vvjv8w 84 12 can can MD cord-254411-e9vvjv8w 84 13 potentially potentially RB cord-254411-e9vvjv8w 84 14 be be VB cord-254411-e9vvjv8w 84 15 considered consider VBN cord-254411-e9vvjv8w 84 16 as as IN cord-254411-e9vvjv8w 84 17 a a DT cord-254411-e9vvjv8w 84 18 crucial crucial JJ cord-254411-e9vvjv8w 84 19 component component NN cord-254411-e9vvjv8w 84 20 in in IN cord-254411-e9vvjv8w 84 21 the the DT cord-254411-e9vvjv8w 84 22 infectivity infectivity NN cord-254411-e9vvjv8w 84 23 and and CC cord-254411-e9vvjv8w 84 24 prognosis prognosis NN cord-254411-e9vvjv8w 84 25 of of IN cord-254411-e9vvjv8w 84 26 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 84 27 . . . cord-254411-e9vvjv8w 85 1 With with IN cord-254411-e9vvjv8w 85 2 enhancing enhance VBG cord-254411-e9vvjv8w 85 3 the the DT cord-254411-e9vvjv8w 85 4 c c NNP cord-254411-e9vvjv8w 85 5 - - HYPH cord-254411-e9vvjv8w 85 6 ATP ATP NNP cord-254411-e9vvjv8w 85 7 , , , cord-254411-e9vvjv8w 85 8 improvement improvement NN cord-254411-e9vvjv8w 85 9 in in IN cord-254411-e9vvjv8w 85 10 both both DT cord-254411-e9vvjv8w 85 11 innate innate JJ cord-254411-e9vvjv8w 85 12 and and CC cord-254411-e9vvjv8w 85 13 cytotoxic cytotoxic JJ cord-254411-e9vvjv8w 85 14 immune immune JJ cord-254411-e9vvjv8w 85 15 systems system NNS cord-254411-e9vvjv8w 85 16 is be VBZ cord-254411-e9vvjv8w 85 17 expected expect VBN cord-254411-e9vvjv8w 85 18 . . . cord-254411-e9vvjv8w 86 1 Moreover moreover RB cord-254411-e9vvjv8w 86 2 , , , cord-254411-e9vvjv8w 86 3 an an DT cord-254411-e9vvjv8w 86 4 increase increase NN cord-254411-e9vvjv8w 86 5 in in IN cord-254411-e9vvjv8w 86 6 c c NNP cord-254411-e9vvjv8w 86 7 - - : cord-254411-e9vvjv8w 86 8 ATP ATP NNP cord-254411-e9vvjv8w 86 9 can can MD cord-254411-e9vvjv8w 86 10 potentially potentially RB cord-254411-e9vvjv8w 86 11 have have VB cord-254411-e9vvjv8w 86 12 either either CC cord-254411-e9vvjv8w 86 13 preventive preventive JJ cord-254411-e9vvjv8w 86 14 and and CC cord-254411-e9vvjv8w 86 15 therapeutic therapeutic JJ cord-254411-e9vvjv8w 86 16 effects effect NNS cord-254411-e9vvjv8w 86 17 . . . cord-254411-e9vvjv8w 87 1 The the DT cord-254411-e9vvjv8w 87 2 preventive preventive JJ cord-254411-e9vvjv8w 87 3 effect effect NN cord-254411-e9vvjv8w 87 4 through through IN cord-254411-e9vvjv8w 87 5 activation activation NN cord-254411-e9vvjv8w 87 6 of of IN cord-254411-e9vvjv8w 87 7 initial initial JJ cord-254411-e9vvjv8w 87 8 IFN-1 IFN-1 NNP cord-254411-e9vvjv8w 87 9 secretion secretion NN cord-254411-e9vvjv8w 87 10 and and CC cord-254411-e9vvjv8w 87 11 signaling signaling NN cord-254411-e9vvjv8w 87 12 , , , cord-254411-e9vvjv8w 87 13 as as IN cord-254411-e9vvjv8w 87 14 " " `` cord-254411-e9vvjv8w 87 15 initial initial JJ cord-254411-e9vvjv8w 87 16 alarm alarm NN cord-254411-e9vvjv8w 87 17 " " '' cord-254411-e9vvjv8w 87 18 of of IN cord-254411-e9vvjv8w 87 19 the the DT cord-254411-e9vvjv8w 87 20 innate innate JJ cord-254411-e9vvjv8w 87 21 immune immune JJ cord-254411-e9vvjv8w 87 22 system system NN cord-254411-e9vvjv8w 87 23 . . . cord-254411-e9vvjv8w 88 1 The the DT cord-254411-e9vvjv8w 88 2 therapeutic therapeutic JJ cord-254411-e9vvjv8w 88 3 effect effect NN cord-254411-e9vvjv8w 88 4 through through IN cord-254411-e9vvjv8w 88 5 the the DT cord-254411-e9vvjv8w 88 6 prevention prevention NN cord-254411-e9vvjv8w 88 7 of of IN cord-254411-e9vvjv8w 88 8 " " `` cord-254411-e9vvjv8w 88 9 cytokine cytokine NN cord-254411-e9vvjv8w 88 10 storm storm NN cord-254411-e9vvjv8w 88 11 " " '' cord-254411-e9vvjv8w 88 12 and and CC cord-254411-e9vvjv8w 88 13 T t NN cord-254411-e9vvjv8w 88 14 - - HYPH cord-254411-e9vvjv8w 88 15 cell cell NN cord-254411-e9vvjv8w 88 16 apoptosis apoptosis NN cord-254411-e9vvjv8w 88 17 . . . cord-254411-e9vvjv8w 89 1 There there EX cord-254411-e9vvjv8w 89 2 are be VBP cord-254411-e9vvjv8w 89 3 several several JJ cord-254411-e9vvjv8w 89 4 approaches approach NNS cord-254411-e9vvjv8w 89 5 to to TO cord-254411-e9vvjv8w 89 6 improve improve VB cord-254411-e9vvjv8w 89 7 c c NNP cord-254411-e9vvjv8w 89 8 - - HYPH cord-254411-e9vvjv8w 89 9 ATP ATP NNP cord-254411-e9vvjv8w 89 10 . . . cord-254411-e9vvjv8w 90 1 Most Most JJS cord-254411-e9vvjv8w 90 2 of of IN cord-254411-e9vvjv8w 90 3 them -PRON- PRP cord-254411-e9vvjv8w 90 4 are be VBP cord-254411-e9vvjv8w 90 5 easily easily RB cord-254411-e9vvjv8w 90 6 available available JJ cord-254411-e9vvjv8w 90 7 through through IN cord-254411-e9vvjv8w 90 8 a a DT cord-254411-e9vvjv8w 90 9 change change NN cord-254411-e9vvjv8w 90 10 in in IN cord-254411-e9vvjv8w 90 11 lifestyle lifestyle NN cord-254411-e9vvjv8w 90 12 . . . cord-254411-e9vvjv8w 91 1 First first RB cord-254411-e9vvjv8w 91 2 , , , cord-254411-e9vvjv8w 91 3 regular regular JJ cord-254411-e9vvjv8w 91 4 exercise exercise NN cord-254411-e9vvjv8w 91 5 improves improve VBZ cord-254411-e9vvjv8w 91 6 mitochondrial mitochondrial JJ cord-254411-e9vvjv8w 91 7 respiratory respiratory JJ cord-254411-e9vvjv8w 91 8 capacity capacity NN cord-254411-e9vvjv8w 91 9 through through IN cord-254411-e9vvjv8w 91 10 an an DT cord-254411-e9vvjv8w 91 11 increase increase NN cord-254411-e9vvjv8w 91 12 in in IN cord-254411-e9vvjv8w 91 13 PGC-1α PGC-1α NNP cord-254411-e9vvjv8w 91 14 ( ( -LRB- cord-254411-e9vvjv8w 91 15 18 18 CD cord-254411-e9vvjv8w 91 16 ) ) -RRB- cord-254411-e9vvjv8w 91 17 . . . cord-254411-e9vvjv8w 92 1 Smoking smoking NN cord-254411-e9vvjv8w 92 2 cessation cessation NN cord-254411-e9vvjv8w 92 3 is be VBZ cord-254411-e9vvjv8w 92 4 the the DT cord-254411-e9vvjv8w 92 5 second second JJ cord-254411-e9vvjv8w 92 6 approach approach NN cord-254411-e9vvjv8w 92 7 to to TO cord-254411-e9vvjv8w 92 8 improve improve VB cord-254411-e9vvjv8w 92 9 mitochondrial mitochondrial JJ cord-254411-e9vvjv8w 92 10 capacity capacity NN cord-254411-e9vvjv8w 92 11 and and CC cord-254411-e9vvjv8w 92 12 improvement improvement NN cord-254411-e9vvjv8w 92 13 in in IN cord-254411-e9vvjv8w 92 14 c c NNP cord-254411-e9vvjv8w 92 15 - - HYPH cord-254411-e9vvjv8w 92 16 ATP ATP NNP cord-254411-e9vvjv8w 92 17 ( ( -LRB- cord-254411-e9vvjv8w 92 18 as as IN cord-254411-e9vvjv8w 92 19 mentioned mention VBN cord-254411-e9vvjv8w 92 20 above above RB cord-254411-e9vvjv8w 92 21 ) ) -RRB- cord-254411-e9vvjv8w 92 22 . . . cord-254411-e9vvjv8w 93 1 Consuming consume VBG cord-254411-e9vvjv8w 93 2 foods food NNS cord-254411-e9vvjv8w 93 3 with with IN cord-254411-e9vvjv8w 93 4 low low JJ cord-254411-e9vvjv8w 93 5 specific specific JJ cord-254411-e9vvjv8w 93 6 dynamic dynamic JJ cord-254411-e9vvjv8w 93 7 action action NN cord-254411-e9vvjv8w 93 8 ( ( -LRB- cord-254411-e9vvjv8w 93 9 SDA SDA NNP cord-254411-e9vvjv8w 93 10 ) ) -RRB- cord-254411-e9vvjv8w 93 11 , , , cord-254411-e9vvjv8w 93 12 as as IN cord-254411-e9vvjv8w 93 13 the the DT cord-254411-e9vvjv8w 93 14 energetic energetic JJ cord-254411-e9vvjv8w 93 15 budget budget NN cord-254411-e9vvjv8w 93 16 for for IN cord-254411-e9vvjv8w 93 17 consuming consume VBG cord-254411-e9vvjv8w 93 18 food food NN cord-254411-e9vvjv8w 93 19 , , , cord-254411-e9vvjv8w 93 20 can can MD cord-254411-e9vvjv8w 93 21 potentially potentially RB cord-254411-e9vvjv8w 93 22 boost boost VB cord-254411-e9vvjv8w 93 23 the the DT cord-254411-e9vvjv8w 93 24 immune immune JJ cord-254411-e9vvjv8w 93 25 system system NN cord-254411-e9vvjv8w 93 26 through through IN cord-254411-e9vvjv8w 93 27 improving improve VBG cord-254411-e9vvjv8w 93 28 the the DT cord-254411-e9vvjv8w 93 29 c c NNP cord-254411-e9vvjv8w 93 30 - - HYPH cord-254411-e9vvjv8w 93 31 ATP ATP NNP cord-254411-e9vvjv8w 93 32 . . . cord-254411-e9vvjv8w 94 1 In in IN cord-254411-e9vvjv8w 94 2 2016 2016 CD cord-254411-e9vvjv8w 94 3 , , , cord-254411-e9vvjv8w 94 4 Luoma Luoma NNP cord-254411-e9vvjv8w 94 5 et et NNP cord-254411-e9vvjv8w 94 6 al al NNP cord-254411-e9vvjv8w 94 7 . . NNP cord-254411-e9vvjv8w 94 8 demonstrated demonstrate VBD cord-254411-e9vvjv8w 94 9 the the DT cord-254411-e9vvjv8w 94 10 effect effect NN cord-254411-e9vvjv8w 94 11 of of IN cord-254411-e9vvjv8w 94 12 low low JJ cord-254411-e9vvjv8w 94 13 - - HYPH cord-254411-e9vvjv8w 94 14 SDA SDA NNP cord-254411-e9vvjv8w 94 15 meals meal NNS cord-254411-e9vvjv8w 94 16 in in IN cord-254411-e9vvjv8w 94 17 the the DT cord-254411-e9vvjv8w 94 18 up up JJ cord-254411-e9vvjv8w 94 19 - - HYPH cord-254411-e9vvjv8w 94 20 regulation regulation NN cord-254411-e9vvjv8w 94 21 of of IN cord-254411-e9vvjv8w 94 22 the the DT cord-254411-e9vvjv8w 94 23 innate innate JJ cord-254411-e9vvjv8w 94 24 immune immune JJ cord-254411-e9vvjv8w 94 25 system system NN cord-254411-e9vvjv8w 94 26 in in IN cord-254411-e9vvjv8w 94 27 corn corn NN cord-254411-e9vvjv8w 94 28 snakes snake NNS cord-254411-e9vvjv8w 94 29 ( ( -LRB- cord-254411-e9vvjv8w 94 30 19 19 CD cord-254411-e9vvjv8w 94 31 ) ) -RRB- cord-254411-e9vvjv8w 94 32 . . . cord-254411-e9vvjv8w 95 1 On on IN cord-254411-e9vvjv8w 95 2 the the DT cord-254411-e9vvjv8w 95 3 other other JJ cord-254411-e9vvjv8w 95 4 hand hand NN cord-254411-e9vvjv8w 95 5 , , , cord-254411-e9vvjv8w 95 6 several several JJ cord-254411-e9vvjv8w 95 7 studies study NNS cord-254411-e9vvjv8w 95 8 have have VBP cord-254411-e9vvjv8w 95 9 reported report VBN cord-254411-e9vvjv8w 95 10 the the DT cord-254411-e9vvjv8w 95 11 positive positive JJ cord-254411-e9vvjv8w 95 12 effect effect NN cord-254411-e9vvjv8w 95 13 of of IN cord-254411-e9vvjv8w 95 14 xanthine xanthine NN cord-254411-e9vvjv8w 95 15 oxidoreductase oxidoreductase NN cord-254411-e9vvjv8w 95 16 inhibitors inhibitor NNS cord-254411-e9vvjv8w 95 17 on on IN cord-254411-e9vvjv8w 95 18 c c NNP cord-254411-e9vvjv8w 95 19 - - HYPH cord-254411-e9vvjv8w 95 20 ATP ATP NNP cord-254411-e9vvjv8w 95 21 ( ( -LRB- cord-254411-e9vvjv8w 95 22 6 6 CD cord-254411-e9vvjv8w 95 23 ) ) -RRB- cord-254411-e9vvjv8w 95 24 . . . cord-254411-e9vvjv8w 96 1 This this DT cord-254411-e9vvjv8w 96 2 hypothesis hypothesis NN cord-254411-e9vvjv8w 96 3 provides provide VBZ cord-254411-e9vvjv8w 96 4 a a DT cord-254411-e9vvjv8w 96 5 new new JJ cord-254411-e9vvjv8w 96 6 concept concept NN cord-254411-e9vvjv8w 96 7 to to TO cord-254411-e9vvjv8w 96 8 improve improve VB cord-254411-e9vvjv8w 96 9 the the DT cord-254411-e9vvjv8w 96 10 immune immune JJ cord-254411-e9vvjv8w 96 11 system system NN cord-254411-e9vvjv8w 96 12 against against IN cord-254411-e9vvjv8w 96 13 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 96 14 . . . cord-254411-e9vvjv8w 97 1 It -PRON- PRP cord-254411-e9vvjv8w 97 2 demonstrates demonstrate VBZ cord-254411-e9vvjv8w 97 3 how how WRB cord-254411-e9vvjv8w 97 4 an an DT cord-254411-e9vvjv8w 97 5 increase increase NN cord-254411-e9vvjv8w 97 6 in in IN cord-254411-e9vvjv8w 97 7 c c NNP cord-254411-e9vvjv8w 97 8 - - : cord-254411-e9vvjv8w 97 9 ATP ATP NNP cord-254411-e9vvjv8w 97 10 can can MD cord-254411-e9vvjv8w 97 11 decrease decrease VB cord-254411-e9vvjv8w 97 12 the the DT cord-254411-e9vvjv8w 97 13 effect effect NN cord-254411-e9vvjv8w 97 14 of of IN cord-254411-e9vvjv8w 97 15 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 97 16 on on IN cord-254411-e9vvjv8w 97 17 immune immune JJ cord-254411-e9vvjv8w 97 18 dysregulation dysregulation NN cord-254411-e9vvjv8w 97 19 . . . cord-254411-e9vvjv8w 98 1 Considering consider VBG cord-254411-e9vvjv8w 98 2 the the DT cord-254411-e9vvjv8w 98 3 strategies strategy NNS cord-254411-e9vvjv8w 98 4 to to TO cord-254411-e9vvjv8w 98 5 enhance enhance VB cord-254411-e9vvjv8w 98 6 cellular cellular JJ cord-254411-e9vvjv8w 98 7 ATP ATP NNP cord-254411-e9vvjv8w 98 8 , , , cord-254411-e9vvjv8w 98 9 improvement improvement NN cord-254411-e9vvjv8w 98 10 of of IN cord-254411-e9vvjv8w 98 11 the the DT cord-254411-e9vvjv8w 98 12 immune immune JJ cord-254411-e9vvjv8w 98 13 system system NN cord-254411-e9vvjv8w 98 14 against against IN cord-254411-e9vvjv8w 98 15 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 98 16 is be VBZ cord-254411-e9vvjv8w 98 17 possible possible JJ cord-254411-e9vvjv8w 98 18 . . . cord-254411-e9vvjv8w 99 1 It -PRON- PRP cord-254411-e9vvjv8w 99 2 is be VBZ cord-254411-e9vvjv8w 99 3 hoped hope VBN cord-254411-e9vvjv8w 99 4 that that IN cord-254411-e9vvjv8w 99 5 this this DT cord-254411-e9vvjv8w 99 6 hypothesis hypothesis NN cord-254411-e9vvjv8w 99 7 will will MD cord-254411-e9vvjv8w 99 8 serve serve VB cord-254411-e9vvjv8w 99 9 as as IN cord-254411-e9vvjv8w 99 10 a a DT cord-254411-e9vvjv8w 99 11 stimulus stimulus NN cord-254411-e9vvjv8w 99 12 for for IN cord-254411-e9vvjv8w 99 13 further further JJ cord-254411-e9vvjv8w 99 14 investigation investigation NN cord-254411-e9vvjv8w 99 15 into into IN cord-254411-e9vvjv8w 99 16 this this DT cord-254411-e9vvjv8w 99 17 issue issue NN cord-254411-e9vvjv8w 99 18 . . . cord-254411-e9vvjv8w 100 1 Genomic genomic JJ cord-254411-e9vvjv8w 100 2 characterisation characterisation NN cord-254411-e9vvjv8w 100 3 and and CC cord-254411-e9vvjv8w 100 4 epidemiology epidemiology NN cord-254411-e9vvjv8w 100 5 of of IN cord-254411-e9vvjv8w 100 6 2019 2019 CD cord-254411-e9vvjv8w 100 7 novel novel JJ cord-254411-e9vvjv8w 100 8 coronavirus coronavirus NN cord-254411-e9vvjv8w 100 9 : : : cord-254411-e9vvjv8w 100 10 implications implication NNS cord-254411-e9vvjv8w 100 11 for for IN cord-254411-e9vvjv8w 100 12 virus virus NN cord-254411-e9vvjv8w 100 13 origins origin NNS cord-254411-e9vvjv8w 100 14 and and CC cord-254411-e9vvjv8w 100 15 receptor receptor NN cord-254411-e9vvjv8w 100 16 binding bind VBG cord-254411-e9vvjv8w 100 17 SARS SARS NNP cord-254411-e9vvjv8w 100 18 - - HYPH cord-254411-e9vvjv8w 100 19 CoV CoV NNP cord-254411-e9vvjv8w 100 20 and and CC cord-254411-e9vvjv8w 100 21 IFN IFN NNP cord-254411-e9vvjv8w 100 22 : : : cord-254411-e9vvjv8w 100 23 too too RB cord-254411-e9vvjv8w 100 24 little little JJ cord-254411-e9vvjv8w 100 25 , , , cord-254411-e9vvjv8w 100 26 too too RB cord-254411-e9vvjv8w 100 27 late late JJ cord-254411-e9vvjv8w 100 28 SARS SARS NNP cord-254411-e9vvjv8w 100 29 and and CC cord-254411-e9vvjv8w 100 30 MERS MERS NNP cord-254411-e9vvjv8w 100 31 : : : cord-254411-e9vvjv8w 100 32 recent recent JJ cord-254411-e9vvjv8w 100 33 insights insight NNS cord-254411-e9vvjv8w 100 34 into into IN cord-254411-e9vvjv8w 100 35 emerging emerge VBG cord-254411-e9vvjv8w 100 36 coronaviruses coronaviruse NNS cord-254411-e9vvjv8w 100 37 Immune immune JJ cord-254411-e9vvjv8w 100 38 responses response NNS cord-254411-e9vvjv8w 100 39 in in IN cord-254411-e9vvjv8w 100 40 COVID-19 covid-19 JJ cord-254411-e9vvjv8w 100 41 and and CC cord-254411-e9vvjv8w 100 42 potential potential JJ cord-254411-e9vvjv8w 100 43 vaccines vaccine NNS cord-254411-e9vvjv8w 100 44 : : : cord-254411-e9vvjv8w 100 45 Lessons lesson NNS cord-254411-e9vvjv8w 100 46 learned learn VBN cord-254411-e9vvjv8w 100 47 from from IN cord-254411-e9vvjv8w 100 48 SARS SARS NNP cord-254411-e9vvjv8w 100 49 and and CC cord-254411-e9vvjv8w 100 50 MERS MERS NNP cord-254411-e9vvjv8w 100 51 epidemic epidemic NN cord-254411-e9vvjv8w 101 1 Dysregulated Dysregulated NNP cord-254411-e9vvjv8w 101 2 Type Type NNP cord-254411-e9vvjv8w 102 1 I -PRON- PRP cord-254411-e9vvjv8w 103 1 Interferon interferon NN cord-254411-e9vvjv8w 103 2 and and CC cord-254411-e9vvjv8w 103 3 Inflammatory inflammatory JJ cord-254411-e9vvjv8w 103 4 Monocyte Monocyte NNP cord-254411-e9vvjv8w 103 5 - - HYPH cord-254411-e9vvjv8w 103 6 Macrophage Macrophage NNP cord-254411-e9vvjv8w 103 7 Responses response NNS cord-254411-e9vvjv8w 104 1 Cause cause VB cord-254411-e9vvjv8w 104 2 Lethal lethal JJ cord-254411-e9vvjv8w 104 3 Pneumonia pneumonia NN cord-254411-e9vvjv8w 104 4 in in IN cord-254411-e9vvjv8w 105 1 SARS SARS NNP cord-254411-e9vvjv8w 105 2 - - HYPH cord-254411-e9vvjv8w 105 3 CoV CoV NNP cord-254411-e9vvjv8w 105 4 - - HYPH cord-254411-e9vvjv8w 105 5 Infected infected JJ cord-254411-e9vvjv8w 105 6 Mice Mice NNP cord-254411-e9vvjv8w 105 7 Shortage shortage NN cord-254411-e9vvjv8w 105 8 of of IN cord-254411-e9vvjv8w 105 9 Cellular Cellular NNP cord-254411-e9vvjv8w 105 10 ATP ATP NNP cord-254411-e9vvjv8w 105 11 as as IN cord-254411-e9vvjv8w 105 12 a a DT cord-254411-e9vvjv8w 105 13 Cause cause NN cord-254411-e9vvjv8w 105 14 of of IN cord-254411-e9vvjv8w 105 15 Diseases disease NNS cord-254411-e9vvjv8w 105 16 and and CC cord-254411-e9vvjv8w 105 17 Strategies strategy NNS cord-254411-e9vvjv8w 106 1 to to TO cord-254411-e9vvjv8w 106 2 Enhance enhance VB cord-254411-e9vvjv8w 106 3 ATP ATP NNP cord-254411-e9vvjv8w 106 4 Virus Virus NNP cord-254411-e9vvjv8w 106 5 - - HYPH cord-254411-e9vvjv8w 106 6 triggered trigger VBN cord-254411-e9vvjv8w 106 7 ATP ATP NNP cord-254411-e9vvjv8w 106 8 release release NN cord-254411-e9vvjv8w 106 9 limits limit VBZ cord-254411-e9vvjv8w 106 10 viral viral JJ cord-254411-e9vvjv8w 106 11 replication replication NN cord-254411-e9vvjv8w 106 12 through through IN cord-254411-e9vvjv8w 106 13 facilitating facilitate VBG cord-254411-e9vvjv8w 106 14 IFN IFN NNP cord-254411-e9vvjv8w 106 15 - - HYPH cord-254411-e9vvjv8w 106 16 β β NN cord-254411-e9vvjv8w 106 17 production production NN cord-254411-e9vvjv8w 106 18 in in IN cord-254411-e9vvjv8w 106 19 a a DT cord-254411-e9vvjv8w 106 20 P2X7-dependent p2x7-dependent NN cord-254411-e9vvjv8w 106 21 manner manner NN cord-254411-e9vvjv8w 107 1 The the DT cord-254411-e9vvjv8w 107 2 role role NN cord-254411-e9vvjv8w 107 3 of of IN cord-254411-e9vvjv8w 107 4 JAK JAK NNP cord-254411-e9vvjv8w 107 5 - - HYPH cord-254411-e9vvjv8w 107 6 STAT STAT NNP cord-254411-e9vvjv8w 107 7 signaling signal VBG cord-254411-e9vvjv8w 107 8 pathway pathway NN cord-254411-e9vvjv8w 107 9 and and CC cord-254411-e9vvjv8w 107 10 its -PRON- PRP$ cord-254411-e9vvjv8w 107 11 regulators regulator NNS cord-254411-e9vvjv8w 107 12 in in IN cord-254411-e9vvjv8w 107 13 the the DT cord-254411-e9vvjv8w 107 14 fate fate NN cord-254411-e9vvjv8w 107 15 of of IN cord-254411-e9vvjv8w 107 16 T T NNP cord-254411-e9vvjv8w 107 17 helper helper NN cord-254411-e9vvjv8w 107 18 cells cell NNS cord-254411-e9vvjv8w 107 19 Control Control NNP cord-254411-e9vvjv8w 107 20 of of IN cord-254411-e9vvjv8w 107 21 coronavirus coronavirus NN cord-254411-e9vvjv8w 107 22 infection infection NN cord-254411-e9vvjv8w 107 23 through through IN cord-254411-e9vvjv8w 107 24 plasmacytoid plasmacytoid JJ cord-254411-e9vvjv8w 107 25 dendritic dendritic JJ cord-254411-e9vvjv8w 107 26 - - HYPH cord-254411-e9vvjv8w 107 27 cell cell NN cord-254411-e9vvjv8w 107 28 - - HYPH cord-254411-e9vvjv8w 107 29 derived derive VBN cord-254411-e9vvjv8w 107 30 type type NN cord-254411-e9vvjv8w 108 1 I -PRON- PRP cord-254411-e9vvjv8w 108 2 interferon interferon VBD cord-254411-e9vvjv8w 108 3 Mitochondrial mitochondrial JJ cord-254411-e9vvjv8w 108 4 hyperpolarization hyperpolarization NN cord-254411-e9vvjv8w 108 5 : : : cord-254411-e9vvjv8w 108 6 a a DT cord-254411-e9vvjv8w 108 7 checkpoint checkpoint NN cord-254411-e9vvjv8w 108 8 of of IN cord-254411-e9vvjv8w 108 9 T t NN cord-254411-e9vvjv8w 108 10 - - HYPH cord-254411-e9vvjv8w 108 11 cell cell NN cord-254411-e9vvjv8w 108 12 life life NN cord-254411-e9vvjv8w 108 13 , , , cord-254411-e9vvjv8w 108 14 death death NN cord-254411-e9vvjv8w 108 15 and and CC cord-254411-e9vvjv8w 108 16 autoimmunity autoimmunity NN cord-254411-e9vvjv8w 108 17 Characteristics characteristic NNS cord-254411-e9vvjv8w 108 18 of of IN cord-254411-e9vvjv8w 108 19 and and CC cord-254411-e9vvjv8w 108 20 important important JJ cord-254411-e9vvjv8w 108 21 lessons lesson NNS cord-254411-e9vvjv8w 108 22 from from IN cord-254411-e9vvjv8w 108 23 the the DT cord-254411-e9vvjv8w 108 24 coronavirus coronavirus NN cord-254411-e9vvjv8w 108 25 disease disease NN cord-254411-e9vvjv8w 108 26 2019 2019 CD cord-254411-e9vvjv8w 108 27 ( ( -LRB- cord-254411-e9vvjv8w 108 28 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 108 29 ) ) -RRB- cord-254411-e9vvjv8w 108 30 outbreak outbreak NN cord-254411-e9vvjv8w 108 31 in in IN cord-254411-e9vvjv8w 108 32 China China NNP cord-254411-e9vvjv8w 108 33 : : : cord-254411-e9vvjv8w 108 34 summary summary NN cord-254411-e9vvjv8w 108 35 of of IN cord-254411-e9vvjv8w 108 36 a a DT cord-254411-e9vvjv8w 108 37 report report NN cord-254411-e9vvjv8w 108 38 of of IN cord-254411-e9vvjv8w 108 39 72 72 CD cord-254411-e9vvjv8w 108 40 314 314 CD cord-254411-e9vvjv8w 108 41 cases case NNS cord-254411-e9vvjv8w 108 42 from from IN cord-254411-e9vvjv8w 108 43 the the DT cord-254411-e9vvjv8w 108 44 Chinese Chinese NNP cord-254411-e9vvjv8w 108 45 Center Center NNP cord-254411-e9vvjv8w 108 46 for for IN cord-254411-e9vvjv8w 108 47 Disease Disease NNP cord-254411-e9vvjv8w 108 48 Control Control NNP cord-254411-e9vvjv8w 108 49 and and CC cord-254411-e9vvjv8w 108 50 Prevention Prevention NNP cord-254411-e9vvjv8w 109 1 Is be VBZ cord-254411-e9vvjv8w 109 2 there there EX cord-254411-e9vvjv8w 109 3 a a DT cord-254411-e9vvjv8w 109 4 link link NN cord-254411-e9vvjv8w 109 5 between between IN cord-254411-e9vvjv8w 109 6 mitochondrial mitochondrial JJ cord-254411-e9vvjv8w 109 7 reserve reserve NN cord-254411-e9vvjv8w 109 8 respiratory respiratory JJ cord-254411-e9vvjv8w 109 9 capacity capacity NN cord-254411-e9vvjv8w 109 10 and and CC cord-254411-e9vvjv8w 109 11 aging age VBG cord-254411-e9vvjv8w 109 12 Impaired impair VBN cord-254411-e9vvjv8w 109 13 interferon interferon NN cord-254411-e9vvjv8w 109 14 signaling signal VBG cord-254411-e9vvjv8w 109 15 in in IN cord-254411-e9vvjv8w 109 16 dendritic dendritic JJ cord-254411-e9vvjv8w 109 17 cells cell NNS cord-254411-e9vvjv8w 109 18 from from IN cord-254411-e9vvjv8w 109 19 older old JJR cord-254411-e9vvjv8w 109 20 donors donor NNS cord-254411-e9vvjv8w 109 21 infected infect VBN cord-254411-e9vvjv8w 109 22 in in IN cord-254411-e9vvjv8w 109 23 vitro vitro FW cord-254411-e9vvjv8w 109 24 with with IN cord-254411-e9vvjv8w 109 25 West West NNP cord-254411-e9vvjv8w 109 26 Nile Nile NNP cord-254411-e9vvjv8w 109 27 virus virus NN cord-254411-e9vvjv8w 109 28 Mitochondria Mitochondria NNP cord-254411-e9vvjv8w 109 29 as as IN cord-254411-e9vvjv8w 109 30 a a DT cord-254411-e9vvjv8w 109 31 possible possible JJ cord-254411-e9vvjv8w 109 32 target target NN cord-254411-e9vvjv8w 109 33 for for IN cord-254411-e9vvjv8w 109 34 nicotine nicotine NN cord-254411-e9vvjv8w 109 35 action action NN cord-254411-e9vvjv8w 109 36 Gender Gender NNP cord-254411-e9vvjv8w 109 37 differences difference NNS cord-254411-e9vvjv8w 109 38 in in IN cord-254411-e9vvjv8w 109 39 patients patient NNS cord-254411-e9vvjv8w 109 40 with with IN cord-254411-e9vvjv8w 109 41 COVID-19 covid-19 NN cord-254411-e9vvjv8w 109 42 : : : cord-254411-e9vvjv8w 109 43 Focus focus VB cord-254411-e9vvjv8w 109 44 on on IN cord-254411-e9vvjv8w 109 45 severity severity NN cord-254411-e9vvjv8w 109 46 and and CC cord-254411-e9vvjv8w 109 47 mortality mortality NN cord-254411-e9vvjv8w 109 48 . . . cord-254411-e9vvjv8w 110 1 medRxiv medRxiv NNP cord-254411-e9vvjv8w 110 2 Estrogen Estrogen NNP cord-254411-e9vvjv8w 110 3 receptor receptor NN cord-254411-e9vvjv8w 110 4 signaling signal VBG cord-254411-e9vvjv8w 110 5 and and CC cord-254411-e9vvjv8w 110 6 its -PRON- PRP$ cord-254411-e9vvjv8w 110 7 relationship relationship NN cord-254411-e9vvjv8w 110 8 to to IN cord-254411-e9vvjv8w 110 9 cytokines cytokine NNS cord-254411-e9vvjv8w 110 10 in in IN cord-254411-e9vvjv8w 110 11 systemic systemic JJ cord-254411-e9vvjv8w 110 12 lupus lupus NN cord-254411-e9vvjv8w 110 13 erythematosus erythematosus NN cord-254411-e9vvjv8w 111 1 Clinical clinical JJ cord-254411-e9vvjv8w 111 2 course course NN cord-254411-e9vvjv8w 111 3 and and CC cord-254411-e9vvjv8w 111 4 risk risk NN cord-254411-e9vvjv8w 111 5 factors factor NNS cord-254411-e9vvjv8w 111 6 for for IN cord-254411-e9vvjv8w 111 7 mortality mortality NN cord-254411-e9vvjv8w 111 8 of of IN cord-254411-e9vvjv8w 111 9 adult adult NN cord-254411-e9vvjv8w 111 10 inpatients inpatient NNS cord-254411-e9vvjv8w 111 11 with with IN cord-254411-e9vvjv8w 111 12 COVID-19 COVID-19 NNP cord-254411-e9vvjv8w 111 13 in in IN cord-254411-e9vvjv8w 111 14 Wuhan Wuhan NNP cord-254411-e9vvjv8w 111 15 , , , cord-254411-e9vvjv8w 111 16 China China NNP cord-254411-e9vvjv8w 111 17 : : : cord-254411-e9vvjv8w 111 18 a a DT cord-254411-e9vvjv8w 111 19 retrospective retrospective JJ cord-254411-e9vvjv8w 111 20 cohort cohort NN cord-254411-e9vvjv8w 111 21 study study NN cord-254411-e9vvjv8w 111 22 . . . cord-254411-e9vvjv8w 112 1 The the DT cord-254411-e9vvjv8w 112 2 Lancet Lancet NNP cord-254411-e9vvjv8w 112 3 Endurance Endurance NNP cord-254411-e9vvjv8w 112 4 training training NN cord-254411-e9vvjv8w 112 5 induces induce VBZ cord-254411-e9vvjv8w 112 6 muscle muscle NN cord-254411-e9vvjv8w 112 7 - - HYPH cord-254411-e9vvjv8w 112 8 specific specific JJ cord-254411-e9vvjv8w 112 9 changes change NNS cord-254411-e9vvjv8w 112 10 in in IN cord-254411-e9vvjv8w 112 11 mitochondrial mitochondrial JJ cord-254411-e9vvjv8w 112 12 function function NN cord-254411-e9vvjv8w 112 13 in in IN cord-254411-e9vvjv8w 112 14 skinned skinned JJ cord-254411-e9vvjv8w 112 15 muscle muscle NN cord-254411-e9vvjv8w 112 16 fibers fiber NNS cord-254411-e9vvjv8w 112 17 Plasticity Plasticity NNP cord-254411-e9vvjv8w 112 18 of of IN cord-254411-e9vvjv8w 112 19 immunity immunity NN cord-254411-e9vvjv8w 112 20 in in IN cord-254411-e9vvjv8w 112 21 response response NN cord-254411-e9vvjv8w 112 22 to to IN cord-254411-e9vvjv8w 112 23 eating eat VBG cord-254411-e9vvjv8w 112 24 The the DT cord-254411-e9vvjv8w 112 25 authors author NNS cord-254411-e9vvjv8w 112 26 have have VBP cord-254411-e9vvjv8w 112 27 no no DT cord-254411-e9vvjv8w 112 28 conflicts conflict NNS cord-254411-e9vvjv8w 112 29 of of IN cord-254411-e9vvjv8w 112 30 interest interest NN cord-254411-e9vvjv8w 112 31 . . . cord-254411-e9vvjv8w 113 1 Not not RB cord-254411-e9vvjv8w 113 2 applicable applicable JJ cord-254411-e9vvjv8w 113 3 . . .