id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352911-9wbq9qo2	de Oliveira, Pedro Gonçalves	Diacerein: a potential multi-target therapeutic drug for COVID-19	2020-06-01		.txt	text/plain	2539	135	45	The mortality related to severe acute respiratory distress syndrome (ARDS) and multi-organ failure in COVID-19 patients has been suggested to be connected with cytokine storm syndrome (CSS), an excessive immune response that severely damages healthy lung tissue. Total extracts from monolayer cell cultures infected with SARS-CoV-2 and treated with rhein under the conditions described above will be analysed using commercially available protein arrays to determine the levels and activation state of proteins involved in the TLR-, Akt-, MAPK-, and NF-B-regulated signalling pathways. The mechanisms of action involved include the control of hyperinflammatory conditions by multi-faceted cytokine inhibition of IL-1, IL-2, IL-6, IL-8, IL-12, IL-18 and TNF-α; anti-platelet aggregation activity; and potential effects on viral infection and replication. Rhein suppresses lung inflammatory injury induced by human respiratory syncytial virus through inhibiting NLRP3 inflammasome activation via NF-κB pathway in mice	./cache/cord-352911-9wbq9qo2.txt	./txt/cord-352911-9wbq9qo2.txt