id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334709-z70oevy2	Niv, Yaron	Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 Disease	2020-09-04		.txt	text/plain	1372	72	51	Similarly, to other corona viruses and influenza A, the receptor for adherence of SARS-CoV-2 is ACE2 which is abundant on respiratory and gastrointestinal mucosal cells, especially on alveolar type 2 pneumocytes [2] . Theoretically using of recombinant S1 protein, which will attach to the ACE2 receptors, may actively compete with the SARS-CoV-19 and prevent infection. They found affinity of HDEF5 binding to ACE2 of 76.2 nM, efficient blocking of SARS-CoV-2 receptor binding domain (RBD), and significant inhibition of invasion into Caco-2 cells. The next step, after preparing recombinant HDEF5, active and functioning, with high affinity to both receptor and ligand, is to make the protein available in powder, with small enough particles to be aerosolized and sprayed. Blocking the receptor for SARS-CoV-2 virus, ACE2, on the respiratory tract epithelium, especially the alveolar type 2 pneumocytes, will probably prevent invasion of the virus, at least for a short while.	./cache/cord-334709-z70oevy2.txt	./txt/cord-334709-z70oevy2.txt