id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323749-lvtfv7ny	Sai Suresh Chalichem, Nehru	Aminoglycosides can be a better choice over Macrolides in COVID-19 regimen: Plausible Mechanism for repurposing strategy	2020-06-10		.txt	text/plain	938	61	46	Although macrolides like azithromycin and clarithromycin etc., have been reported to act against respiratory infections but they lack the ability of immunity enhancement through defensins. The aminoglycosides were proved to have defensin mediated antiviral activity, that could enhance the immunity. So, Consideration of aminoglycosides can be a double edge sword viz., against respiratory infection as well as Immunity enhancer (along with anti-virals) for COVID-19 regimen. Although various nations throughout the globe making several strategies viz, different drug combinations, proposing lock downs and herd immunity etc., to control the wide spread of COVID-19 and to tolerate its severity, the radical behaviour of virus is evident. In the instances like current pandemic of COVID-19, where infection control becomes a great challenge, immune mediators could be a vital link. However, aminoglycosides (AGs) were proved to produce functional peptides from theta defensins (called as retrocyclins) that are active against HIV 10 .	./cache/cord-323749-lvtfv7ny.txt	./txt/cord-323749-lvtfv7ny.txt