id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311673-z4hkw17g	Uzzan, Mathieu	Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - lung axis hypothesis	2020-06-23		.txt	text/plain	2969	154	40	As the visceral fat possesses an intense immune activity, is involved in metabolic syndrome and is at the crossroad between the intestines, the systemic circulation and the lung, we hypothesized that it plays a major role in severe forms of SARS-CoV-2 infection. Several factors may increase intestinal permeability including, direct enterocyte damage by SARS-CoV2, systemic inflammatory response syndrome (SIRS) and epithelial ischemia secondary to SARS-CoV2associated endothelial dysfunction. This increase permeability further leads to translocation of microbial components such as MAMPS (microbial-associated molecular pattern), triggering an inflammatory immune response by TLR-expressing cells of the mesentery fat (mostly macrophages and adipocytes). As the increased volume of mesentery fat in overweight men play a key role in the occurrence of metabolic syndrome [8] , we hypothesized that the visceral adipose tissue plays a central role in severe forms of COVID-19.	./cache/cord-311673-z4hkw17g.txt	./txt/cord-311673-z4hkw17g.txt