id author title date pages extension mime words sentences flesch summary cache txt cord-308279-gsk4qel5 Suzuki, Yuichiro J. The viral protein fragment theory of COVID-19 pathogenesis 2020-09-11 .txt text/plain 1397 70 44 I herein propose the viral protein fragment theory of COVID-19 pathogenesis based on my observations in cultured human vascular cells that SARS-CoV-2 spike protein can activate cell signaling events without the rest of the viral components. I hypothesize that, as humans are infected with SARS-CoV-2, the virus releases a fragment of the spike protein that can target host cells for eliciting cell signaling without the rest of the viral components. This hypothesis is based on my experimental observations in cultured human vascular cells that the recombinant full length S1 subunit of SARS-CoV-2 spike protein can activate cell signaling events without the rest of the viral components. I propose a scenario that, as humans are infected with SARS-CoV-2, the virus releases a fragment of the spike protein that can target host cells for eliciting cell signaling. ./cache/cord-308279-gsk4qel5.txt ./txt/cord-308279-gsk4qel5.txt