id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306146-i4a74j3r	Fitzgerald, Paul J.	Noradrenergic and serotonergic drugs may have opposing effects on COVID-19 cytokine storm and associated psychological effects	2020-06-09		.txt	text/plain	573	37	33	In addition to its role in various psychiatric, neurologic, and cardiovascular functions, there is increasing evidence that NE plays a role in the symptomatology associated with serious systemic infections such as influenza, including activation of cytokine signaling such as IL-6 as well as the manifestation of psychological effects associated with infection 3 . I suggest here that this cytokine storm may be counteracted by a range of clinically used drugs that reduce NE transmission (but that may not act through direct effects on viral replication or viral entry into cells) 5 : alpha2 agonists such as clonidine, guanfacine, dexmedetomidine; various beta blockers such as propranolol, nebivolol, carvedilol, atenolol; and various alpha1 antagonists such as prazosin 4 . If COVID-19 is accompanied by systemically elevated NE signaling, the various drugs listed above may also counteract deleterious psychological effects associated with this infection 3 . Conflicts of interest The author reports no conflicts of interest, and no funding source directly supported this work	./cache/cord-306146-i4a74j3r.txt	./txt/cord-306146-i4a74j3r.txt