id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299911-v95pf3eg	El-Ghiaty, Mahmoud A.	Cytochrome P450-mediated drug interactions in COVID-19 patients: current findings and possible mechanisms	2020-06-26		.txt	text/plain	5319	272	37	Based on the conclusions drawn from the currently rapidly evolving knowledge about COVID-19, our hypothesis is built on the potential modulation of CYPs activity by the inflammatory environment provoked by SARS-CoV-2 infection, as well as the pathologic involvement of the liver which harbors the majority of the drug metabolizing enzymes (DMEs). Systemic inflammation and immune response represent a substantial element in many acute and chronic diseases which is strongly implicated in altering drug pharmacokinetics through, mainly, modulating the expression and activity of DMEs. As a main contributor to the metabolic biotransformation of most drugs, CYPs are widely involved in such disease-drug interactions [19] . For decades, IL-6 has been recognized as the major inflammatory element that provokes a significant repressive effect on the expression and activity of different CYPs. Human recombinant interleukin 6 (rhIL-6) has shown concentration-dependent blocking of phenobarbital-mediated induction of CYP2B1/2 mRNA and activity in rat hepatocytes [48] .	./cache/cord-299911-v95pf3eg.txt	./txt/cord-299911-v95pf3eg.txt