id author title date pages extension mime words sentences flesch summary cache txt cord-275569-i5y23mmz de Bernardis, E. A putative role for the tobacco mosaic virus in smokers’ resistance to COVID-19 2020-07-31 .txt text/plain 1500 69 41 Though it is intuitively tempting, on the basis of physiopathological common knowledge, to predict a greater risk of contracting the SARS-CoV-2 infection in tobacco smokers, an analysis of studies from various countries shows that hospitalized COVID-19 patients have a lower, and apparently inversely proportional, rate of current tobacco smoking, in comparison with the respective general population, although once the disease has developed meta-analyses suggest that smoking is associated with a worse prognosis [1] . Incidentally, this behavior reminds the proposed effects of tobacco smoking, protective against initial SARS-CoV-2 infection and deleterious in the florid phase of the COVID-19 disease. Taken together, all these elements suggest that the oral use of tobacco, continuously exposing to non-pathogenic but immunogenic TMV particles, and chronically stimulating a natural antiviral response, may induce a state of resistance to the initial SARS-CoV-2 infection. ./cache/cord-275569-i5y23mmz.txt ./txt/cord-275569-i5y23mmz.txt