id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258272-uu6t6tnh	Dabaghian, Farid	Bioactive compounds with possible inhibitory activity of Angiotensin-Converting Enzyme-II; a gate to manage and prevent COVID-19	2020-05-16		.txt	text/plain	302	27	50	key: cord-258272-uu6t6tnh title: Bioactive compounds with possible inhibitory activity of Angiotensin-Converting Enzyme-II; a gate to manage and prevent COVID-19 cord_uid: uu6t6tnh Angiotensin-Converting Enzyme-II (ACE-II) receptor, most likely the COVID-19 target, plays essential roles in virus transmission to the alveolar cells (2) . Accordingly, agents with potential inhibition or regulation of ACE-II receptors might be effective in COVID-19 management (3) . Glycyrrhizin can inhibit COVID-19 S-protein binding to ACE-II receptors (7) . Emodin, a bioactive antiviral agent may prevent S-protein binding to ACE-II receptors. Thus, Emodin and probably Aloe-emodin can stave off the COVID-19 infection via competing with S-protein in binding to ACE-II (7) . Angiotensin converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system Potential natural compounds for preventing 2019-nCoV infection Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction Anti-SARS coronavirus 3C-like protease effects of Rheum palmatum L. The authors of this manuscript have no conflict of interest.	./cache/cord-258272-uu6t6tnh.txt	./txt/cord-258272-uu6t6tnh.txt