id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254411-e9vvjv8w	Taghizadeh-Hesary, Farzad	The Powerful Immune System Against Powerful COVID-19: A Hypothesis	2020-04-22		.txt	text/plain	1878	130	49	In this article, we provide a novel hypothesis to describe how an increase in cellular adenosine triphosphate (c-ATP) can potentially improve the efficiency of innate and adaptive immune systems to either prevent and fight off COVID-19. In this article, we aim to provide a new hypothesis to describe how the repletion of cellular adenosine triphosphate (c-ATP) can promote immunity against COVID-19. Secondly, ATP-depletion can potentially prone the recruited immune cells to earlier exhaustion against COVID-19. Therefore, one may conclude that ATP-repletion can prevent the so-called "cytokine storm" and improve the cellular energy to better counteract with COVID-19. From the perspective of cellular energy, this process potentially occurs through IFN-mediated T-cell activation that results in c-ATP depletion. have shown that following IFN-γ stimulation, mitochondrial hyperpolarization and ATP depletion occurs in T-cells that results in apoptosis (10) . It demonstrates how an increase in c-ATP can decrease the effect of COVID-19 on immune dysregulation.	./cache/cord-254411-e9vvjv8w.txt	./txt/cord-254411-e9vvjv8w.txt