id sid tid token lemma pos cord-335432-9aszklx3 1 1 key key JJ cord-335432-9aszklx3 1 2 : : : cord-335432-9aszklx3 1 3 cord-335432 cord-335432 NNP cord-335432-9aszklx3 1 4 - - HYPH cord-335432-9aszklx3 1 5 9aszklx3 9aszklx3 CD cord-335432-9aszklx3 1 6 authors author NNS cord-335432-9aszklx3 1 7 : : : cord-335432-9aszklx3 1 8 Duprex Duprex NNP cord-335432-9aszklx3 1 9 , , , cord-335432-9aszklx3 1 10 W. W. NNP cord-335432-9aszklx3 1 11 Paul Paul NNP cord-335432-9aszklx3 1 12 ; ; : cord-335432-9aszklx3 1 13 Casadevall Casadevall NNP cord-335432-9aszklx3 1 14 , , , cord-335432-9aszklx3 1 15 Arturo Arturo NNP cord-335432-9aszklx3 1 16 title title NN cord-335432-9aszklx3 1 17 : : : cord-335432-9aszklx3 2 1 Falling fall VBG cord-335432-9aszklx3 2 2 down down IN cord-335432-9aszklx3 2 3 the the DT cord-335432-9aszklx3 2 4 Rabbit Rabbit NNP cord-335432-9aszklx3 2 5 Hole Hole NNP cord-335432-9aszklx3 2 6 : : : cord-335432-9aszklx3 3 1 aTRIP aTRIP NNP cord-335432-9aszklx3 4 1 Toward toward IN cord-335432-9aszklx3 4 2 Lexiconic Lexiconic NNP cord-335432-9aszklx3 4 3 Precision Precision NNP cord-335432-9aszklx3 4 4 in in IN cord-335432-9aszklx3 4 5 the the DT cord-335432-9aszklx3 4 6 “ " `` cord-335432-9aszklx3 4 7 Gain gain NN cord-335432-9aszklx3 4 8 - - HYPH cord-335432-9aszklx3 4 9 of of IN cord-335432-9aszklx3 4 10 - - HYPH cord-335432-9aszklx3 4 11 Function function NN cord-335432-9aszklx3 4 12 ” " '' cord-335432-9aszklx3 4 13 Debate debate NN cord-335432-9aszklx3 4 14 date date NN cord-335432-9aszklx3 4 15 : : : cord-335432-9aszklx3 4 16 2014 2014 CD cord-335432-9aszklx3 4 17 - - SYM cord-335432-9aszklx3 4 18 12 12 CD cord-335432-9aszklx3 4 19 - - SYM cord-335432-9aszklx3 4 20 12 12 CD cord-335432-9aszklx3 4 21 journal journal NN cord-335432-9aszklx3 4 22 : : : cord-335432-9aszklx3 5 1 mBio mbio NN cord-335432-9aszklx3 5 2 DOI doi NN cord-335432-9aszklx3 5 3 : : : cord-335432-9aszklx3 6 1 10.1128 10.1128 CD cord-335432-9aszklx3 6 2 / / SYM cord-335432-9aszklx3 6 3 mbio.02421 mbio.02421 NNP cord-335432-9aszklx3 6 4 - - HYPH cord-335432-9aszklx3 6 5 14 14 CD cord-335432-9aszklx3 6 6 sha sha NNP cord-335432-9aszklx3 6 7 : : : cord-335432-9aszklx3 6 8 d8b4bb30789355b295394864873228a15c4868b3 d8b4bb30789355b295394864873228a15c4868b3 ADD cord-335432-9aszklx3 6 9 doc_id doc_id CD cord-335432-9aszklx3 6 10 : : : cord-335432-9aszklx3 6 11 335432 335432 CD cord-335432-9aszklx3 6 12 cord_uid cord_uid NN cord-335432-9aszklx3 6 13 : : : cord-335432-9aszklx3 6 14 9aszklx3 9aszklx3 CD cord-335432-9aszklx3 6 15 nan nan NNP cord-335432-9aszklx3 6 16 blow blow NN cord-335432-9aszklx3 6 17 - - HYPH cord-335432-9aszklx3 6 18 by by IN cord-335432-9aszklx3 6 19 - - HYPH cord-335432-9aszklx3 6 20 blow blow NN cord-335432-9aszklx3 6 21 account account NN cord-335432-9aszklx3 6 22 of of IN cord-335432-9aszklx3 6 23 how how WRB cord-335432-9aszklx3 6 24 we -PRON- PRP cord-335432-9aszklx3 6 25 ended end VBD cord-335432-9aszklx3 6 26 up up RP cord-335432-9aszklx3 6 27 at at IN cord-335432-9aszklx3 6 28 the the DT cord-335432-9aszklx3 6 29 point point NN cord-335432-9aszklx3 6 30 where where WRB cord-335432-9aszklx3 6 31 the the DT cord-335432-9aszklx3 6 32 U.S. U.S. NNP cord-335432-9aszklx3 6 33 Government Government NNP cord-335432-9aszklx3 6 34 instigated instigate VBD cord-335432-9aszklx3 6 35 a a DT cord-335432-9aszklx3 6 36 " " `` cord-335432-9aszklx3 6 37 pause pause NN cord-335432-9aszklx3 6 38 " " '' cord-335432-9aszklx3 6 39 on on IN cord-335432-9aszklx3 6 40 new new JJ cord-335432-9aszklx3 6 41 and and CC cord-335432-9aszklx3 6 42 a a DT cord-335432-9aszklx3 6 43 voluntary voluntary JJ cord-335432-9aszklx3 6 44 cessation cessation NN cord-335432-9aszklx3 6 45 of of IN cord-335432-9aszklx3 6 46 ongoing ongoing JJ cord-335432-9aszklx3 6 47 / / SYM cord-335432-9aszklx3 6 48 funded fund VBN cord-335432-9aszklx3 6 49 virology virology NN cord-335432-9aszklx3 6 50 experiments experiment NNS cord-335432-9aszklx3 6 51 . . . cord-335432-9aszklx3 7 1 However however RB cord-335432-9aszklx3 7 2 , , , cord-335432-9aszklx3 7 3 to to TO cord-335432-9aszklx3 7 4 understand understand VB cord-335432-9aszklx3 7 5 where where WRB cord-335432-9aszklx3 7 6 we -PRON- PRP cord-335432-9aszklx3 7 7 are be VBP cord-335432-9aszklx3 7 8 demands demand NNS cord-335432-9aszklx3 7 9 some some DT cord-335432-9aszklx3 7 10 appreciation appreciation NN cord-335432-9aszklx3 7 11 of of IN cord-335432-9aszklx3 7 12 how how WRB cord-335432-9aszklx3 7 13 virology virology NN cord-335432-9aszklx3 7 14 began begin VBD cord-335432-9aszklx3 7 15 , , , cord-335432-9aszklx3 7 16 the the DT cord-335432-9aszklx3 7 17 types type NNS cord-335432-9aszklx3 7 18 of of IN cord-335432-9aszklx3 7 19 questions question NNS cord-335432-9aszklx3 7 20 virologists virologist NNS cord-335432-9aszklx3 7 21 ask ask VBP cord-335432-9aszklx3 7 22 , , , cord-335432-9aszklx3 7 23 and and CC cord-335432-9aszklx3 7 24 the the DT cord-335432-9aszklx3 7 25 approaches approach NNS cord-335432-9aszklx3 7 26 that that IN cord-335432-9aszklx3 7 27 they -PRON- PRP cord-335432-9aszklx3 7 28 use use VBP cord-335432-9aszklx3 7 29 . . . cord-335432-9aszklx3 8 1 Long long RB cord-335432-9aszklx3 8 2 before before IN cord-335432-9aszklx3 8 3 virology virology NN cord-335432-9aszklx3 8 4 existed exist VBD cord-335432-9aszklx3 8 5 as as IN cord-335432-9aszklx3 8 6 a a DT cord-335432-9aszklx3 8 7 discipline discipline NN cord-335432-9aszklx3 8 8 or or CC cord-335432-9aszklx3 8 9 before before IN cord-335432-9aszklx3 8 10 scientists scientist NNS cord-335432-9aszklx3 8 11 knew know VBD cord-335432-9aszklx3 8 12 what what WP cord-335432-9aszklx3 8 13 viruses virus NNS cord-335432-9aszklx3 8 14 were be VBD cord-335432-9aszklx3 8 15 , , , cord-335432-9aszklx3 8 16 people people NNS cord-335432-9aszklx3 8 17 observed observe VBD cord-335432-9aszklx3 8 18 what what WP cord-335432-9aszklx3 8 19 administration administration NN cord-335432-9aszklx3 8 20 of of IN cord-335432-9aszklx3 8 21 filtered filter VBN cord-335432-9aszklx3 8 22 contagium contagium NNP cord-335432-9aszklx3 8 23 vivum vivum NNP cord-335432-9aszklx3 8 24 fluidum fluidum NNP cord-335432-9aszklx3 8 25 did do VBD cord-335432-9aszklx3 8 26 in in IN cord-335432-9aszklx3 8 27 a a DT cord-335432-9aszklx3 8 28 natural natural JJ cord-335432-9aszklx3 8 29 host host NN cord-335432-9aszklx3 8 30 . . . cord-335432-9aszklx3 9 1 Transmission transmission NN cord-335432-9aszklx3 9 2 experiments experiment NNS cord-335432-9aszklx3 9 3 in in IN cord-335432-9aszklx3 9 4 plants plant NNS cord-335432-9aszklx3 9 5 and and CC cord-335432-9aszklx3 9 6 animals animal NNS cord-335432-9aszklx3 9 7 led lead VBD cord-335432-9aszklx3 9 8 to to IN cord-335432-9aszklx3 9 9 reproducible reproducible JJ cord-335432-9aszklx3 9 10 diseases disease NNS cord-335432-9aszklx3 9 11 , , , cord-335432-9aszklx3 9 12 and and CC cord-335432-9aszklx3 9 13 such such JJ cord-335432-9aszklx3 9 14 approaches approach NNS cord-335432-9aszklx3 9 15 were be VBD cord-335432-9aszklx3 9 16 foundational foundational JJ cord-335432-9aszklx3 9 17 in in IN cord-335432-9aszklx3 9 18 showing show VBG cord-335432-9aszklx3 9 19 the the DT cord-335432-9aszklx3 9 20 absolute absolute JJ cord-335432-9aszklx3 9 21 requirement requirement NN cord-335432-9aszklx3 9 22 of of IN cord-335432-9aszklx3 9 23 living live VBG cord-335432-9aszklx3 9 24 cells cell NNS cord-335432-9aszklx3 9 25 for for IN cord-335432-9aszklx3 9 26 virus virus NN cord-335432-9aszklx3 9 27 growth growth NN cord-335432-9aszklx3 9 28 . . . cord-335432-9aszklx3 10 1 Eggs egg NNS cord-335432-9aszklx3 10 2 ( ( -LRB- cord-335432-9aszklx3 10 3 although although IN cord-335432-9aszklx3 10 4 not not RB cord-335432-9aszklx3 10 5 of of IN cord-335432-9aszklx3 10 6 the the DT cord-335432-9aszklx3 10 7 Humpty Humpty NNP cord-335432-9aszklx3 10 8 variety variety NN cord-335432-9aszklx3 10 9 ) ) -RRB- cord-335432-9aszklx3 10 10 were be VBD cord-335432-9aszklx3 10 11 pivotal pivotal JJ cord-335432-9aszklx3 10 12 , , , cord-335432-9aszklx3 10 13 as as IN cord-335432-9aszklx3 10 14 they -PRON- PRP cord-335432-9aszklx3 10 15 provided provide VBD cord-335432-9aszklx3 10 16 a a DT cord-335432-9aszklx3 10 17 novel novel JJ cord-335432-9aszklx3 10 18 cellular cellular JJ cord-335432-9aszklx3 10 19 substrate substrate NN cord-335432-9aszklx3 10 20 for for IN cord-335432-9aszklx3 10 21 the the DT cord-335432-9aszklx3 10 22 culture culture NN cord-335432-9aszklx3 10 23 of of IN cord-335432-9aszklx3 10 24 influenza influenza NN cord-335432-9aszklx3 10 25 viruses virus NNS cord-335432-9aszklx3 10 26 . . . cord-335432-9aszklx3 11 1 Subsequent subsequent JJ cord-335432-9aszklx3 11 2 development development NN cord-335432-9aszklx3 11 3 of of IN cord-335432-9aszklx3 11 4 in in FW cord-335432-9aszklx3 11 5 vitro vitro FW cord-335432-9aszklx3 11 6 cell cell NN cord-335432-9aszklx3 11 7 culture culture NN cord-335432-9aszklx3 11 8 systems system NNS cord-335432-9aszklx3 11 9 opened open VBD cord-335432-9aszklx3 11 10 the the DT cord-335432-9aszklx3 11 11 door door NN cord-335432-9aszklx3 11 12 for for IN cord-335432-9aszklx3 11 13 virologists virologist NNS cord-335432-9aszklx3 11 14 to to TO cord-335432-9aszklx3 11 15 bring bring VB cord-335432-9aszklx3 11 16 dangerous dangerous JJ cord-335432-9aszklx3 11 17 pathogens pathogen NNS cord-335432-9aszklx3 11 18 into into IN cord-335432-9aszklx3 11 19 the the DT cord-335432-9aszklx3 11 20 laboratory laboratory NN cord-335432-9aszklx3 11 21 . . . cord-335432-9aszklx3 12 1 What what WP cord-335432-9aszklx3 12 2 is be VBZ cord-335432-9aszklx3 12 3 important important JJ cord-335432-9aszklx3 12 4 to to TO cord-335432-9aszklx3 12 5 appreciate appreciate VB cord-335432-9aszklx3 12 6 is be VBZ cord-335432-9aszklx3 12 7 that that IN cord-335432-9aszklx3 12 8 these these DT cord-335432-9aszklx3 12 9 approaches approach NNS cord-335432-9aszklx3 12 10 established establish VBD cord-335432-9aszklx3 12 11 a a DT cord-335432-9aszklx3 12 12 basic basic JJ cord-335432-9aszklx3 12 13 principle principle NN cord-335432-9aszklx3 12 14 in in IN cord-335432-9aszklx3 12 15 virology virology NN cord-335432-9aszklx3 12 16 : : : cord-335432-9aszklx3 12 17 the the DT cord-335432-9aszklx3 12 18 use use NN cord-335432-9aszklx3 12 19 of of IN cord-335432-9aszklx3 12 20 unnatural unnatural JJ cord-335432-9aszklx3 12 21 cell cell NN cord-335432-9aszklx3 12 22 substrates substrate NNS cord-335432-9aszklx3 12 23 to to IN cord-335432-9aszklx3 12 24 culture culture NN cord-335432-9aszklx3 12 25 viruses virus NNS cord-335432-9aszklx3 12 26 . . . cord-335432-9aszklx3 13 1 As as IN cord-335432-9aszklx3 13 2 viruses virus NNS cord-335432-9aszklx3 13 3 are be VBP cord-335432-9aszklx3 13 4 obligate obligate VBN cord-335432-9aszklx3 13 5 intracellular intracellular JJ cord-335432-9aszklx3 13 6 pathogens pathogen NNS cord-335432-9aszklx3 13 7 that that WDT cord-335432-9aszklx3 13 8 infect infect VBP cord-335432-9aszklx3 13 9 bacteria bacteria NNS cord-335432-9aszklx3 13 10 , , , cord-335432-9aszklx3 13 11 plants plant NNS cord-335432-9aszklx3 13 12 , , , cord-335432-9aszklx3 13 13 animals animal NNS cord-335432-9aszklx3 13 14 , , , cord-335432-9aszklx3 13 15 and and CC cord-335432-9aszklx3 13 16 humans human NNS cord-335432-9aszklx3 13 17 , , , cord-335432-9aszklx3 13 18 the the DT cord-335432-9aszklx3 13 19 very very JJ cord-335432-9aszklx3 13 20 act act NN cord-335432-9aszklx3 13 21 of of IN cord-335432-9aszklx3 13 22 introducing introduce VBG cord-335432-9aszklx3 13 23 a a DT cord-335432-9aszklx3 13 24 virus virus NN cord-335432-9aszklx3 13 25 into into IN cord-335432-9aszklx3 13 26 a a DT cord-335432-9aszklx3 13 27 new new JJ cord-335432-9aszklx3 13 28 environment environment NN cord-335432-9aszklx3 13 29 will will MD cord-335432-9aszklx3 13 30 drive drive VB cord-335432-9aszklx3 13 31 evolutionary evolutionary JJ cord-335432-9aszklx3 13 32 adaptations adaptation NNS cord-335432-9aszklx3 13 33 . . . cord-335432-9aszklx3 14 1 Changes change NNS cord-335432-9aszklx3 14 2 in in IN cord-335432-9aszklx3 14 3 the the DT cord-335432-9aszklx3 14 4 genome genome NN cord-335432-9aszklx3 14 5 during during IN cord-335432-9aszklx3 14 6 tissue tissue NN cord-335432-9aszklx3 14 7 culture culture NN cord-335432-9aszklx3 14 8 adaptation adaptation NN cord-335432-9aszklx3 14 9 lead lead NN cord-335432-9aszklx3 14 10 to to IN cord-335432-9aszklx3 14 11 alterations alteration NNS cord-335432-9aszklx3 14 12 in in IN cord-335432-9aszklx3 14 13 the the DT cord-335432-9aszklx3 14 14 phenotype phenotype NN cord-335432-9aszklx3 14 15 as as IN cord-335432-9aszklx3 14 16 functions function NNS cord-335432-9aszklx3 14 17 are be VBP cord-335432-9aszklx3 14 18 gained gain VBN cord-335432-9aszklx3 14 19 and and CC cord-335432-9aszklx3 14 20 lost lose VBN cord-335432-9aszklx3 14 21 . . . cord-335432-9aszklx3 15 1 This this DT cord-335432-9aszklx3 15 2 fact fact NN cord-335432-9aszklx3 15 3 seems seem VBZ cord-335432-9aszklx3 15 4 to to TO cord-335432-9aszklx3 15 5 have have VB cord-335432-9aszklx3 15 6 been be VBN cord-335432-9aszklx3 15 7 lost lose VBN cord-335432-9aszklx3 15 8 in in IN cord-335432-9aszklx3 15 9 the the DT cord-335432-9aszklx3 15 10 ongoing ongoing JJ cord-335432-9aszklx3 15 11 debate debate NN cord-335432-9aszklx3 15 12 into into IN cord-335432-9aszklx3 15 13 the the DT cord-335432-9aszklx3 15 14 creation creation NN cord-335432-9aszklx3 15 15 of of IN cord-335432-9aszklx3 15 16 novel novel NN cord-335432-9aszklx3 15 17 viruses virus NNS cord-335432-9aszklx3 15 18 , , , cord-335432-9aszklx3 15 19 and and CC cord-335432-9aszklx3 15 20 it -PRON- PRP cord-335432-9aszklx3 15 21 is be VBZ cord-335432-9aszklx3 15 22 both both CC cord-335432-9aszklx3 15 23 simplistic simplistic JJ cord-335432-9aszklx3 15 24 and and CC cord-335432-9aszklx3 15 25 incorrect incorrect JJ cord-335432-9aszklx3 15 26 to to TO cord-335432-9aszklx3 15 27 apply apply VB cord-335432-9aszklx3 15 28 the the DT cord-335432-9aszklx3 15 29 term term NN cord-335432-9aszklx3 15 30 " " `` cord-335432-9aszklx3 15 31 gain gain NN cord-335432-9aszklx3 15 32 of of IN cord-335432-9aszklx3 15 33 function function NN cord-335432-9aszklx3 15 34 " " '' cord-335432-9aszklx3 15 35 to to IN cord-335432-9aszklx3 15 36 a a DT cord-335432-9aszklx3 15 37 small small JJ cord-335432-9aszklx3 15 38 subset subset NN cord-335432-9aszklx3 15 39 of of IN cord-335432-9aszklx3 15 40 influenza influenza NN cord-335432-9aszklx3 15 41 transmission transmission NN cord-335432-9aszklx3 15 42 experiments experiment NNS cord-335432-9aszklx3 15 43 . . . cord-335432-9aszklx3 16 1 How how WRB cord-335432-9aszklx3 16 2 did do VBD cord-335432-9aszklx3 16 3 we -PRON- PRP cord-335432-9aszklx3 16 4 find find VB cord-335432-9aszklx3 16 5 ourselves -PRON- PRP cord-335432-9aszklx3 16 6 in in IN cord-335432-9aszklx3 16 7 this this DT cord-335432-9aszklx3 16 8 lexiconic lexiconic JJ cord-335432-9aszklx3 16 9 morass morass NN cord-335432-9aszklx3 16 10 ? ? . cord-335432-9aszklx3 17 1 By by IN cord-335432-9aszklx3 17 2 not not RB cord-335432-9aszklx3 17 3 appreciating appreciate VBG cord-335432-9aszklx3 17 4 the the DT cord-335432-9aszklx3 17 5 history history NN cord-335432-9aszklx3 17 6 of of IN cord-335432-9aszklx3 17 7 virology virology NN cord-335432-9aszklx3 17 8 , , , cord-335432-9aszklx3 17 9 by by IN cord-335432-9aszklx3 17 10 not not RB cord-335432-9aszklx3 17 11 recognizing recognize VBG cord-335432-9aszklx3 17 12 that that IN cord-335432-9aszklx3 17 13 " " `` cord-335432-9aszklx3 17 14 gain gain NN cord-335432-9aszklx3 17 15 of of IN cord-335432-9aszklx3 17 16 function function NN cord-335432-9aszklx3 17 17 " " '' cord-335432-9aszklx3 17 18 is be VBZ cord-335432-9aszklx3 17 19 a a DT cord-335432-9aszklx3 17 20 term term NN cord-335432-9aszklx3 17 21 used use VBN cord-335432-9aszklx3 17 22 by by IN cord-335432-9aszklx3 17 23 geneticists geneticist NNS cord-335432-9aszklx3 17 24 , , , cord-335432-9aszklx3 17 25 not not RB cord-335432-9aszklx3 17 26 virologists virologist NNS cord-335432-9aszklx3 17 27 , , , cord-335432-9aszklx3 17 28 and and CC cord-335432-9aszklx3 17 29 by by IN cord-335432-9aszklx3 17 30 not not RB cord-335432-9aszklx3 17 31 nipping nip VBG cord-335432-9aszklx3 17 32 usage usage NN cord-335432-9aszklx3 17 33 of of IN cord-335432-9aszklx3 17 34 this this DT cord-335432-9aszklx3 17 35 misnomer misnomer NN cord-335432-9aszklx3 17 36 in in IN cord-335432-9aszklx3 17 37 the the DT cord-335432-9aszklx3 17 38 bud bud NN cord-335432-9aszklx3 17 39 from from IN cord-335432-9aszklx3 17 40 the the DT cord-335432-9aszklx3 17 41 outset outset NN cord-335432-9aszklx3 17 42 . . . cord-335432-9aszklx3 18 1 At at IN cord-335432-9aszklx3 18 2 this this DT cord-335432-9aszklx3 18 3 juncture juncture NN cord-335432-9aszklx3 18 4 , , , cord-335432-9aszklx3 18 5 it -PRON- PRP cord-335432-9aszklx3 18 6 is be VBZ cord-335432-9aszklx3 18 7 reasonable reasonable JJ cord-335432-9aszklx3 18 8 to to TO cord-335432-9aszklx3 18 9 ask ask VB cord-335432-9aszklx3 18 10 , , , cord-335432-9aszklx3 18 11 " " `` cord-335432-9aszklx3 18 12 is be VBZ cord-335432-9aszklx3 18 13 it -PRON- PRP cord-335432-9aszklx3 18 14 possible possible JJ cord-335432-9aszklx3 18 15 to to TO cord-335432-9aszklx3 18 16 extract extract VB cord-335432-9aszklx3 18 17 ourselves -PRON- PRP cord-335432-9aszklx3 18 18 from from IN cord-335432-9aszklx3 18 19 this this DT cord-335432-9aszklx3 18 20 rabbit rabbit NN cord-335432-9aszklx3 18 21 hole hole NN cord-335432-9aszklx3 18 22 ? ? . cord-335432-9aszklx3 19 1 " " `` cord-335432-9aszklx3 19 2 It -PRON- PRP cord-335432-9aszklx3 19 3 could could MD cord-335432-9aszklx3 19 4 be be VB cord-335432-9aszklx3 19 5 argued argue VBN cord-335432-9aszklx3 19 6 that that IN cord-335432-9aszklx3 19 7 expending expend VBG cord-335432-9aszklx3 19 8 any any DT cord-335432-9aszklx3 19 9 effort effort NN cord-335432-9aszklx3 19 10 on on IN cord-335432-9aszklx3 19 11 such such JJ cord-335432-9aszklx3 19 12 semantics semantic NNS cord-335432-9aszklx3 19 13 is be VBZ cord-335432-9aszklx3 19 14 unwise unwise JJ cord-335432-9aszklx3 19 15 and and CC cord-335432-9aszklx3 19 16 that that IN cord-335432-9aszklx3 19 17 it -PRON- PRP cord-335432-9aszklx3 19 18 is be VBZ cord-335432-9aszklx3 19 19 impossible impossible JJ cord-335432-9aszklx3 19 20 to to TO cord-335432-9aszklx3 19 21 let let VB cord-335432-9aszklx3 19 22 go go VB cord-335432-9aszklx3 19 23 of of IN cord-335432-9aszklx3 19 24 GOF GOF NNP cord-335432-9aszklx3 19 25 . . . cord-335432-9aszklx3 20 1 However however RB cord-335432-9aszklx3 20 2 , , , cord-335432-9aszklx3 20 3 we -PRON- PRP cord-335432-9aszklx3 20 4 contend contend VBP cord-335432-9aszklx3 20 5 that that IN cord-335432-9aszklx3 20 6 this this DT cord-335432-9aszklx3 20 7 is be VBZ cord-335432-9aszklx3 20 8 a a DT cord-335432-9aszklx3 20 9 defeatist defeatist JJ cord-335432-9aszklx3 20 10 approach approach NN cord-335432-9aszklx3 20 11 , , , cord-335432-9aszklx3 20 12 and and CC cord-335432-9aszklx3 20 13 rather rather RB cord-335432-9aszklx3 20 14 than than IN cord-335432-9aszklx3 20 15 complain complain VB cord-335432-9aszklx3 20 16 about about IN cord-335432-9aszklx3 20 17 the the DT cord-335432-9aszklx3 20 18 problems problem NNS cord-335432-9aszklx3 20 19 of of IN cord-335432-9aszklx3 20 20 the the DT cord-335432-9aszklx3 20 21 past past NN cord-335432-9aszklx3 20 22 will will MD cord-335432-9aszklx3 20 23 suggest suggest VB cord-335432-9aszklx3 20 24 more more RBR cord-335432-9aszklx3 20 25 - - HYPH cord-335432-9aszklx3 20 26 precise precise JJ cord-335432-9aszklx3 20 27 terminology terminology NN cord-335432-9aszklx3 20 28 which which WDT cord-335432-9aszklx3 20 29 could could MD cord-335432-9aszklx3 20 30 be be VB cord-335432-9aszklx3 20 31 used use VBN cord-335432-9aszklx3 20 32 in in IN cord-335432-9aszklx3 20 33 the the DT cord-335432-9aszklx3 20 34 future future NN cord-335432-9aszklx3 20 35 . . . cord-335432-9aszklx3 21 1 In in IN cord-335432-9aszklx3 21 2 fact fact NN cord-335432-9aszklx3 21 3 , , , cord-335432-9aszklx3 21 4 changes change NNS cord-335432-9aszklx3 21 5 in in IN cord-335432-9aszklx3 21 6 the the DT cord-335432-9aszklx3 21 7 common common JJ cord-335432-9aszklx3 21 8 lexicon lexicon NN cord-335432-9aszklx3 21 9 in in IN cord-335432-9aszklx3 21 10 recent recent JJ cord-335432-9aszklx3 21 11 years year NNS cord-335432-9aszklx3 21 12 show show VBP cord-335432-9aszklx3 21 13 that that IN cord-335432-9aszklx3 21 14 terminology terminology NN cord-335432-9aszklx3 21 15 can can MD cord-335432-9aszklx3 21 16 indeed indeed RB cord-335432-9aszklx3 21 17 be be VB cord-335432-9aszklx3 21 18 altered alter VBN cord-335432-9aszklx3 21 19 , , , cord-335432-9aszklx3 21 20 as as IN cord-335432-9aszklx3 21 21 evidenced evidence VBN cord-335432-9aszklx3 21 22 by by IN cord-335432-9aszklx3 21 23 the the DT cord-335432-9aszklx3 21 24 switch switch NN cord-335432-9aszklx3 21 25 from from IN cord-335432-9aszklx3 21 26 " " `` cord-335432-9aszklx3 21 27 stewardess stewardess NN cord-335432-9aszklx3 21 28 " " '' cord-335432-9aszklx3 21 29 to to IN cord-335432-9aszklx3 21 30 " " `` cord-335432-9aszklx3 21 31 flight flight NN cord-335432-9aszklx3 21 32 attendant attendant NN cord-335432-9aszklx3 21 33 , , , cord-335432-9aszklx3 21 34 " " '' cord-335432-9aszklx3 21 35 " " `` cord-335432-9aszklx3 21 36 handicapped handicapped JJ cord-335432-9aszklx3 21 37 " " '' cord-335432-9aszklx3 21 38 to to IN cord-335432-9aszklx3 21 39 " " `` cord-335432-9aszklx3 21 40 disabled disabled JJ cord-335432-9aszklx3 21 41 , , , cord-335432-9aszklx3 21 42 " " '' cord-335432-9aszklx3 21 43 and and CC cord-335432-9aszklx3 21 44 " " `` cord-335432-9aszklx3 21 45 third third JJ cord-335432-9aszklx3 21 46 world world NN cord-335432-9aszklx3 21 47 " " '' cord-335432-9aszklx3 21 48 to to IN cord-335432-9aszklx3 21 49 " " `` cord-335432-9aszklx3 21 50 underresourced underresourced JJ cord-335432-9aszklx3 21 51 , , , cord-335432-9aszklx3 21 52 " " '' cord-335432-9aszklx3 21 53 if if IN cord-335432-9aszklx3 21 54 there there EX cord-335432-9aszklx3 21 55 is be VBZ cord-335432-9aszklx3 21 56 a a DT cord-335432-9aszklx3 21 57 need need NN cord-335432-9aszklx3 21 58 for for IN cord-335432-9aszklx3 21 59 better well JJR cord-335432-9aszklx3 21 60 usage usage NN cord-335432-9aszklx3 21 61 . . . cord-335432-9aszklx3 22 1 In in IN cord-335432-9aszklx3 22 2 writing write VBG cord-335432-9aszklx3 22 3 this this DT cord-335432-9aszklx3 22 4 opinion opinion NN cord-335432-9aszklx3 22 5 piece piece NN cord-335432-9aszklx3 22 6 , , , cord-335432-9aszklx3 22 7 we -PRON- PRP cord-335432-9aszklx3 22 8 reached reach VBD cord-335432-9aszklx3 22 9 out out RP cord-335432-9aszklx3 22 10 to to IN cord-335432-9aszklx3 22 11 a a DT cord-335432-9aszklx3 22 12 number number NN cord-335432-9aszklx3 22 13 of of IN cord-335432-9aszklx3 22 14 colleagues colleague NNS cord-335432-9aszklx3 22 15 vested vest VBN cord-335432-9aszklx3 22 16 in in IN cord-335432-9aszklx3 22 17 this this DT cord-335432-9aszklx3 22 18 debate debate NN cord-335432-9aszklx3 22 19 , , , cord-335432-9aszklx3 22 20 some some DT cord-335432-9aszklx3 22 21 of of IN cord-335432-9aszklx3 22 22 whom whom WP cord-335432-9aszklx3 22 23 are be VBP cord-335432-9aszklx3 22 24 grappling grapple VBG cord-335432-9aszklx3 22 25 with with IN cord-335432-9aszklx3 22 26 what what WP cord-335432-9aszklx3 22 27 it -PRON- PRP cord-335432-9aszklx3 22 28 means mean VBZ cord-335432-9aszklx3 22 29 for for IN cord-335432-9aszklx3 22 30 their -PRON- PRP$ cord-335432-9aszklx3 22 31 studies study NNS cord-335432-9aszklx3 22 32 to to TO cord-335432-9aszklx3 22 33 be be VB cord-335432-9aszklx3 22 34 " " `` cord-335432-9aszklx3 22 35 paused pause VBN cord-335432-9aszklx3 22 36 " " '' cord-335432-9aszklx3 22 37 and and CC cord-335432-9aszklx3 22 38 others other NNS cord-335432-9aszklx3 22 39 of of IN cord-335432-9aszklx3 22 40 whom whom WP cord-335432-9aszklx3 22 41 see see VBP cord-335432-9aszklx3 22 42 the the DT cord-335432-9aszklx3 22 43 value value NN cord-335432-9aszklx3 22 44 in in IN cord-335432-9aszklx3 22 45 halting halt VBG cord-335432-9aszklx3 22 46 experiments experiment NNS cord-335432-9aszklx3 22 47 which which WDT cord-335432-9aszklx3 22 48 might may MD cord-335432-9aszklx3 22 49 lead lead VB cord-335432-9aszklx3 22 50 to to IN cord-335432-9aszklx3 22 51 the the DT cord-335432-9aszklx3 22 52 generation generation NN cord-335432-9aszklx3 22 53 of of IN cord-335432-9aszklx3 22 54 potentially potentially RB cord-335432-9aszklx3 22 55 problematic problematic JJ cord-335432-9aszklx3 22 56 pathogens pathogen NNS cord-335432-9aszklx3 22 57 . . . cord-335432-9aszklx3 23 1 What what WP cord-335432-9aszklx3 23 2 follows follow VBZ cord-335432-9aszklx3 23 3 is be VBZ cord-335432-9aszklx3 23 4 a a DT cord-335432-9aszklx3 23 5 synthesis synthesis NN cord-335432-9aszklx3 23 6 of of IN cord-335432-9aszklx3 23 7 our -PRON- PRP$ cord-335432-9aszklx3 23 8 thoughts thought NNS cord-335432-9aszklx3 23 9 , , , cord-335432-9aszklx3 23 10 which which WDT cord-335432-9aszklx3 23 11 have have VBP cord-335432-9aszklx3 23 12 been be VBN cord-335432-9aszklx3 23 13 enhanced enhance VBN cord-335432-9aszklx3 23 14 and and CC cord-335432-9aszklx3 23 15 altered alter VBN cord-335432-9aszklx3 23 16 by by IN cord-335432-9aszklx3 23 17 their -PRON- PRP$ cord-335432-9aszklx3 23 18 comments comment NNS cord-335432-9aszklx3 23 19 and and CC cord-335432-9aszklx3 23 20 concerns concern NNS cord-335432-9aszklx3 23 21 . . . cord-335432-9aszklx3 24 1 It -PRON- PRP cord-335432-9aszklx3 24 2 is be VBZ cord-335432-9aszklx3 24 3 by by IN cord-335432-9aszklx3 24 4 no no DT cord-335432-9aszklx3 24 5 means mean NNS cord-335432-9aszklx3 24 6 meant mean VBN cord-335432-9aszklx3 24 7 to to TO cord-335432-9aszklx3 24 8 be be VB cord-335432-9aszklx3 24 9 prescriptive prescriptive JJ cord-335432-9aszklx3 24 10 , , , cord-335432-9aszklx3 24 11 and and CC cord-335432-9aszklx3 24 12 our -PRON- PRP$ cord-335432-9aszklx3 24 13 goal goal NN cord-335432-9aszklx3 24 14 is be VBZ cord-335432-9aszklx3 24 15 to to TO cord-335432-9aszklx3 24 16 provoke provoke VB cord-335432-9aszklx3 24 17 an an DT cord-335432-9aszklx3 24 18 inclusive inclusive JJ cord-335432-9aszklx3 24 19 discussion discussion NN cord-335432-9aszklx3 24 20 since since IN cord-335432-9aszklx3 24 21 this this DT cord-335432-9aszklx3 24 22 is be VBZ cord-335432-9aszklx3 24 23 long long RB cord-335432-9aszklx3 24 24 overdue overdue JJ cord-335432-9aszklx3 24 25 . . . cord-335432-9aszklx3 25 1 Two two CD cord-335432-9aszklx3 25 2 common common JJ cord-335432-9aszklx3 25 3 mistakes mistake NNS cord-335432-9aszklx3 25 4 involve involve VBP cord-335432-9aszklx3 25 5 confusing confuse VBG cord-335432-9aszklx3 25 6 dual dual JJ cord-335432-9aszklx3 25 7 - - HYPH cord-335432-9aszklx3 25 8 use use NN cord-335432-9aszklx3 25 9 research research NN cord-335432-9aszklx3 25 10 ( ( -LRB- cord-335432-9aszklx3 25 11 DUR DUR NNP cord-335432-9aszklx3 25 12 ) ) -RRB- cord-335432-9aszklx3 25 13 with with IN cord-335432-9aszklx3 25 14 dual dual JJ cord-335432-9aszklx3 25 15 - - HYPH cord-335432-9aszklx3 25 16 use use NN cord-335432-9aszklx3 25 17 research research NN cord-335432-9aszklx3 25 18 of of IN cord-335432-9aszklx3 25 19 concern concern NN cord-335432-9aszklx3 25 20 ( ( -LRB- cord-335432-9aszklx3 25 21 DURC DURC NNP cord-335432-9aszklx3 25 22 ) ) -RRB- cord-335432-9aszklx3 25 23 and and CC cord-335432-9aszklx3 25 24 equating equate VBG cord-335432-9aszklx3 25 25 GOF GOF NNP cord-335432-9aszklx3 25 26 experiments experiment NNS cord-335432-9aszklx3 25 27 with with IN cord-335432-9aszklx3 25 28 DURC DURC NNP cord-335432-9aszklx3 25 29 . . . cord-335432-9aszklx3 26 1 The the DT cord-335432-9aszklx3 26 2 first first JJ cord-335432-9aszklx3 26 3 is be VBZ cord-335432-9aszklx3 26 4 easy easy JJ cord-335432-9aszklx3 26 5 to to TO cord-335432-9aszklx3 26 6 address address VB cord-335432-9aszklx3 26 7 , , , cord-335432-9aszklx3 26 8 as as IN cord-335432-9aszklx3 26 9 DURC DURC NNP cord-335432-9aszklx3 26 10 simply simply RB cord-335432-9aszklx3 26 11 represents represent VBZ cord-335432-9aszklx3 26 12 a a DT cord-335432-9aszklx3 26 13 subset subset NN cord-335432-9aszklx3 26 14 of of IN cord-335432-9aszklx3 26 15 DUR DUR NNP cord-335432-9aszklx3 26 16 ( ( -LRB- cord-335432-9aszklx3 26 17 Fig Fig NNP cord-335432-9aszklx3 26 18 . . . cord-335432-9aszklx3 26 19 1A 1a NN cord-335432-9aszklx3 26 20 ) ) -RRB- cord-335432-9aszklx3 26 21 . . . cord-335432-9aszklx3 27 1 DURC DURC NNP cord-335432-9aszklx3 27 2 is be VBZ cord-335432-9aszklx3 27 3 defined define VBN cord-335432-9aszklx3 27 4 as as IN cord-335432-9aszklx3 27 5 " " `` cord-335432-9aszklx3 27 6 life life NNP cord-335432-9aszklx3 27 7 sciences sciences NNPS cord-335432-9aszklx3 27 8 research research NN cord-335432-9aszklx3 27 9 that that IN cord-335432-9aszklx3 27 10 , , , cord-335432-9aszklx3 27 11 based base VBN cord-335432-9aszklx3 27 12 on on IN cord-335432-9aszklx3 27 13 current current JJ cord-335432-9aszklx3 27 14 understanding understanding NN cord-335432-9aszklx3 27 15 , , , cord-335432-9aszklx3 27 16 can can MD cord-335432-9aszklx3 27 17 be be VB cord-335432-9aszklx3 27 18 reasonably reasonably RB cord-335432-9aszklx3 27 19 anticipated anticipate VBN cord-335432-9aszklx3 27 20 to to TO cord-335432-9aszklx3 27 21 provide provide VB cord-335432-9aszklx3 27 22 knowledge knowledge NN cord-335432-9aszklx3 27 23 , , , cord-335432-9aszklx3 27 24 information information NN cord-335432-9aszklx3 27 25 , , , cord-335432-9aszklx3 27 26 products product NNS cord-335432-9aszklx3 27 27 , , , cord-335432-9aszklx3 27 28 or or CC cord-335432-9aszklx3 27 29 technologies technology NNS cord-335432-9aszklx3 27 30 that that WDT cord-335432-9aszklx3 27 31 could could MD cord-335432-9aszklx3 27 32 be be VB cord-335432-9aszklx3 27 33 directly directly RB cord-335432-9aszklx3 27 34 misused misuse VBN cord-335432-9aszklx3 27 35 to to TO cord-335432-9aszklx3 27 36 pose pose VB cord-335432-9aszklx3 27 37 a a DT cord-335432-9aszklx3 27 38 significant significant JJ cord-335432-9aszklx3 27 39 threat threat NN cord-335432-9aszklx3 27 40 with with IN cord-335432-9aszklx3 27 41 broad broad JJ cord-335432-9aszklx3 27 42 consequences consequence NNS cord-335432-9aszklx3 27 43 to to IN cord-335432-9aszklx3 27 44 public public JJ cord-335432-9aszklx3 27 45 health health NN cord-335432-9aszklx3 27 46 and and CC cord-335432-9aszklx3 27 47 safety safety NN cord-335432-9aszklx3 27 48 , , , cord-335432-9aszklx3 27 49 agricultural agricultural JJ cord-335432-9aszklx3 27 50 crops crop NNS cord-335432-9aszklx3 27 51 and and CC cord-335432-9aszklx3 27 52 other other JJ cord-335432-9aszklx3 27 53 plants plant NNS cord-335432-9aszklx3 27 54 , , , cord-335432-9aszklx3 27 55 animals animal NNS cord-335432-9aszklx3 27 56 , , , cord-335432-9aszklx3 27 57 the the DT cord-335432-9aszklx3 27 58 environment environment NN cord-335432-9aszklx3 27 59 , , , cord-335432-9aszklx3 27 60 or or CC cord-335432-9aszklx3 27 61 national national JJ cord-335432-9aszklx3 27 62 security security NN cord-335432-9aszklx3 27 63 " " '' cord-335432-9aszklx3 27 64 ( ( -LRB- cord-335432-9aszklx3 27 65 2 2 CD cord-335432-9aszklx3 27 66 ) ) -RRB- cord-335432-9aszklx3 27 67 . . . cord-335432-9aszklx3 28 1 Currently currently RB cord-335432-9aszklx3 28 2 , , , cord-335432-9aszklx3 28 3 DURC DURC NNP cord-335432-9aszklx3 28 4 focuses focus VBZ cord-335432-9aszklx3 28 5 on on IN cord-335432-9aszklx3 28 6 15 15 CD cord-335432-9aszklx3 28 7 select select JJ cord-335432-9aszklx3 28 8 agents agent NNS cord-335432-9aszklx3 28 9 , , , cord-335432-9aszklx3 28 10 8 8 CD cord-335432-9aszklx3 28 11 viruses virus NNS cord-335432-9aszklx3 28 12 , , , cord-335432-9aszklx3 28 13 6 6 CD cord-335432-9aszklx3 28 14 bacteria bacteria NNS cord-335432-9aszklx3 28 15 , , , cord-335432-9aszklx3 28 16 and and CC cord-335432-9aszklx3 28 17 1 1 CD cord-335432-9aszklx3 28 18 toxin toxin NN cord-335432-9aszklx3 28 19 ( ( -LRB- cord-335432-9aszklx3 28 20 Fig Fig NNP cord-335432-9aszklx3 28 21 . . . cord-335432-9aszklx3 28 22 1B 1B NNP cord-335432-9aszklx3 28 23 ) ) -RRB- cord-335432-9aszklx3 28 24 , , , cord-335432-9aszklx3 28 25 and and CC cord-335432-9aszklx3 28 26 includes include VBZ cord-335432-9aszklx3 28 27 human human JJ cord-335432-9aszklx3 28 28 , , , cord-335432-9aszklx3 28 29 animal animal NN cord-335432-9aszklx3 28 30 , , , cord-335432-9aszklx3 28 31 zoonotic zoonotic JJ cord-335432-9aszklx3 28 32 , , , cord-335432-9aszklx3 28 33 and and CC cord-335432-9aszklx3 28 34 synthetically synthetically RB cord-335432-9aszklx3 28 35 generated generate VBN cord-335432-9aszklx3 28 36 pathogens pathogen NNS cord-335432-9aszklx3 28 37 , , , cord-335432-9aszklx3 28 38 such such JJ cord-335432-9aszklx3 28 39 as as IN cord-335432-9aszklx3 28 40 variola variola JJ cord-335432-9aszklx3 28 41 major major JJ cord-335432-9aszklx3 28 42 virus virus NN cord-335432-9aszklx3 28 43 , , , cord-335432-9aszklx3 28 44 foot foot NN cord-335432-9aszklx3 28 45 - - HYPH cord-335432-9aszklx3 28 46 and and CC cord-335432-9aszklx3 28 47 - - HYPH cord-335432-9aszklx3 28 48 mouth mouth NN cord-335432-9aszklx3 28 49 disease disease NN cord-335432-9aszklx3 28 50 virus virus NN cord-335432-9aszklx3 28 51 , , , cord-335432-9aszklx3 28 52 the the DT cord-335432-9aszklx3 28 53 reconstructed reconstruct VBN cord-335432-9aszklx3 28 54 1918 1918 CD cord-335432-9aszklx3 28 55 influenza influenza NN cord-335432-9aszklx3 28 56 virus virus NN cord-335432-9aszklx3 28 57 , , , cord-335432-9aszklx3 28 58 and and CC cord-335432-9aszklx3 28 59 Ebola Ebola NNP cord-335432-9aszklx3 28 60 virus virus NN cord-335432-9aszklx3 29 1 ( ( -LRB- cord-335432-9aszklx3 29 2 Fig Fig NNP cord-335432-9aszklx3 29 3 . . . cord-335432-9aszklx3 29 4 1C 1C NNP cord-335432-9aszklx3 29 5 ) ) -RRB- cord-335432-9aszklx3 29 6 . . . cord-335432-9aszklx3 30 1 Three three CD cord-335432-9aszklx3 30 2 have have VBP cord-335432-9aszklx3 30 3 been be VBN cord-335432-9aszklx3 30 4 eradicated eradicate VBN cord-335432-9aszklx3 30 5 from from IN cord-335432-9aszklx3 30 6 general general JJ cord-335432-9aszklx3 30 7 circulation circulation NN cord-335432-9aszklx3 30 8 , , , cord-335432-9aszklx3 30 9 although although IN cord-335432-9aszklx3 30 10 rinderpest rinderpest NN cord-335432-9aszklx3 30 11 virus virus NN cord-335432-9aszklx3 30 12 would would MD cord-335432-9aszklx3 30 13 be be VB cord-335432-9aszklx3 30 14 very very RB cord-335432-9aszklx3 30 15 straightforward straightforward JJ cord-335432-9aszklx3 30 16 to to TO cord-335432-9aszklx3 30 17 reconstruct reconstruct VB cord-335432-9aszklx3 30 18 using use VBG cord-335432-9aszklx3 30 19 reverse reverse NN cord-335432-9aszklx3 30 20 - - HYPH cord-335432-9aszklx3 30 21 genetics genetics NN cord-335432-9aszklx3 30 22 approaches approach NNS cord-335432-9aszklx3 30 23 published publish VBN cord-335432-9aszklx3 30 24 20 20 CD cord-335432-9aszklx3 30 25 years year NNS cord-335432-9aszklx3 30 26 ago ago RB cord-335432-9aszklx3 30 27 , , , cord-335432-9aszklx3 30 28 synthetic synthetic JJ cord-335432-9aszklx3 30 29 biology biology NN cord-335432-9aszklx3 30 30 , , , cord-335432-9aszklx3 30 31 and and CC cord-335432-9aszklx3 30 32 wild wild JJ cord-335432-9aszklx3 30 33 - - HYPH cord-335432-9aszklx3 30 34 type type NN cord-335432-9aszklx3 30 35 genome genome NN cord-335432-9aszklx3 30 36 sequences sequence NNS cord-335432-9aszklx3 30 37 which which WDT cord-335432-9aszklx3 30 38 are be VBP cord-335432-9aszklx3 30 39 in in IN cord-335432-9aszklx3 30 40 the the DT cord-335432-9aszklx3 30 41 public public JJ cord-335432-9aszklx3 30 42 domain domain NN cord-335432-9aszklx3 30 43 ( ( -LRB- cord-335432-9aszklx3 30 44 3 3 CD cord-335432-9aszklx3 30 45 , , , cord-335432-9aszklx3 30 46 4 4 CD cord-335432-9aszklx3 30 47 ) ) -RRB- cord-335432-9aszklx3 30 48 . . . cord-335432-9aszklx3 31 1 Although although IN cord-335432-9aszklx3 31 2 influenza influenza NN cord-335432-9aszklx3 31 3 virus virus NN cord-335432-9aszklx3 31 4 has have VBZ cord-335432-9aszklx3 31 5 not not RB cord-335432-9aszklx3 31 6 been be VBN cord-335432-9aszklx3 31 7 eradicated eradicate VBN cord-335432-9aszklx3 31 8 by by IN cord-335432-9aszklx3 31 9 vaccination vaccination NN cord-335432-9aszklx3 31 10 , , , cord-335432-9aszklx3 31 11 reverse reverse JJ cord-335432-9aszklx3 31 12 genetics genetic NNS cord-335432-9aszklx3 31 13 was be VBD cord-335432-9aszklx3 31 14 used use VBN cord-335432-9aszklx3 31 15 to to TO cord-335432-9aszklx3 31 16 synthesize synthesize VB cord-335432-9aszklx3 31 17 the the DT cord-335432-9aszklx3 31 18 H1N1 H1N1 NNP cord-335432-9aszklx3 31 19 influenza influenza NN cord-335432-9aszklx3 31 20 virus virus NN cord-335432-9aszklx3 31 21 responsible responsible JJ cord-335432-9aszklx3 31 22 for for IN cord-335432-9aszklx3 31 23 the the DT cord-335432-9aszklx3 31 24 1918 1918 CD cord-335432-9aszklx3 31 25 pandemic pandemic NN cord-335432-9aszklx3 31 26 ( ( -LRB- cord-335432-9aszklx3 31 27 5 5 CD cord-335432-9aszklx3 31 28 ) ) -RRB- cord-335432-9aszklx3 31 29 . . . cord-335432-9aszklx3 32 1 Based base VBN cord-335432-9aszklx3 32 2 on on IN cord-335432-9aszklx3 32 3 a a DT cord-335432-9aszklx3 32 4 predication predication NN cord-335432-9aszklx3 32 5 that that IN cord-335432-9aszklx3 32 6 there there EX cord-335432-9aszklx3 32 7 are be VBP cord-335432-9aszklx3 32 8 approximately approximately RB cord-335432-9aszklx3 32 9 320,000 320,000 CD cord-335432-9aszklx3 32 10 mammalian mammalian JJ cord-335432-9aszklx3 32 11 viruses virus NNS cord-335432-9aszklx3 32 12 ( ( -LRB- cord-335432-9aszklx3 32 13 6 6 CD cord-335432-9aszklx3 32 14 ) ) -RRB- cord-335432-9aszklx3 32 15 , , , cord-335432-9aszklx3 32 16 the the DT cord-335432-9aszklx3 32 17 list list NN cord-335432-9aszklx3 32 18 of of IN cord-335432-9aszklx3 32 19 DURC DURC NNP cord-335432-9aszklx3 32 20 - - HYPH cord-335432-9aszklx3 32 21 relevant relevant JJ cord-335432-9aszklx3 32 22 viruses virus NNS cord-335432-9aszklx3 32 23 represents represent VBZ cord-335432-9aszklx3 32 24 a a DT cord-335432-9aszklx3 32 25 mere mere JJ cord-335432-9aszklx3 32 26 0.0025 0.0025 CD cord-335432-9aszklx3 32 27 % % NN cord-335432-9aszklx3 32 28 . . . cord-335432-9aszklx3 33 1 Furthermore furthermore RB cord-335432-9aszklx3 33 2 , , , cord-335432-9aszklx3 33 3 the the DT cord-335432-9aszklx3 33 4 " " `` cord-335432-9aszklx3 33 5 GOF"-research gof"-research NN cord-335432-9aszklx3 33 6 of of IN cord-335432-9aszklx3 33 7 concern concern NN cord-335432-9aszklx3 33 8 represents represent VBZ cord-335432-9aszklx3 33 9 a a DT cord-335432-9aszklx3 33 10 minuscule minuscule JJ cord-335432-9aszklx3 33 11 fraction fraction NN cord-335432-9aszklx3 33 12 of of IN cord-335432-9aszklx3 33 13 the the DT cord-335432-9aszklx3 33 14 virological virological JJ cord-335432-9aszklx3 33 15 research research NN cord-335432-9aszklx3 33 16 portfolio portfolio NN cord-335432-9aszklx3 33 17 and and CC cord-335432-9aszklx3 33 18 is be VBZ cord-335432-9aszklx3 33 19 usually usually RB cord-335432-9aszklx3 33 20 only only RB cord-335432-9aszklx3 33 21 thought think VBN cord-335432-9aszklx3 33 22 of of IN cord-335432-9aszklx3 33 23 as as IN cord-335432-9aszklx3 33 24 influenza influenza NN cord-335432-9aszklx3 33 25 transmission transmission NN cord-335432-9aszklx3 33 26 studies study NNS cord-335432-9aszklx3 33 27 ( ( -LRB- cord-335432-9aszklx3 33 28 Fig Fig NNP cord-335432-9aszklx3 33 29 . . . cord-335432-9aszklx3 33 30 1D 1d CD cord-335432-9aszklx3 33 31 , , , cord-335432-9aszklx3 33 32 red red JJ cord-335432-9aszklx3 33 33 circle circle NN cord-335432-9aszklx3 33 34 ) ) -RRB- cord-335432-9aszklx3 33 35 . . . cord-335432-9aszklx3 34 1 Interestingly interestingly RB cord-335432-9aszklx3 34 2 , , , cord-335432-9aszklx3 34 3 severe severe JJ cord-335432-9aszklx3 34 4 acute acute JJ cord-335432-9aszklx3 34 5 respiratory respiratory JJ cord-335432-9aszklx3 34 6 syndrome syndrome NN cord-335432-9aszklx3 34 7 ( ( -LRB- cord-335432-9aszklx3 34 8 SARS SARS NNP cord-335432-9aszklx3 34 9 ) ) -RRB- cord-335432-9aszklx3 34 10 and and CC cord-335432-9aszklx3 34 11 Middle Middle NNP cord-335432-9aszklx3 34 12 East East NNP cord-335432-9aszklx3 34 13 respiratory respiratory JJ cord-335432-9aszklx3 34 14 syndrome syndrome NN cord-335432-9aszklx3 34 15 ( ( -LRB- cord-335432-9aszklx3 34 16 MERS MERS NNP cord-335432-9aszklx3 34 17 ) ) -RRB- cord-335432-9aszklx3 35 1 viruses virus NNS cord-335432-9aszklx3 35 2 are be VBP cord-335432-9aszklx3 35 3 not not RB cord-335432-9aszklx3 35 4 on on IN cord-335432-9aszklx3 35 5 the the DT cord-335432-9aszklx3 35 6 DURC DURC NNP cord-335432-9aszklx3 35 7 list list NN cord-335432-9aszklx3 35 8 , , , cord-335432-9aszklx3 35 9 even even RB cord-335432-9aszklx3 35 10 though though IN cord-335432-9aszklx3 35 11 work work NN cord-335432-9aszklx3 35 12 with with IN cord-335432-9aszklx3 35 13 these these DT cord-335432-9aszklx3 35 14 is be VBZ cord-335432-9aszklx3 35 15 also also RB cord-335432-9aszklx3 35 16 subject subject JJ cord-335432-9aszklx3 35 17 to to IN cord-335432-9aszklx3 35 18 the the DT cord-335432-9aszklx3 35 19 " " `` cord-335432-9aszklx3 35 20 pause pause NN cord-335432-9aszklx3 35 21 . . . cord-335432-9aszklx3 35 22 " " '' cord-335432-9aszklx3 36 1 This this DT cord-335432-9aszklx3 36 2 demonstrates demonstrate VBZ cord-335432-9aszklx3 36 3 that that IN cord-335432-9aszklx3 36 4 in in IN cord-335432-9aszklx3 36 5 practice practice NN cord-335432-9aszklx3 36 6 , , , cord-335432-9aszklx3 36 7 DURC DURC NNP cord-335432-9aszklx3 36 8 is be VBZ cord-335432-9aszklx3 36 9 wider wide JJR cord-335432-9aszklx3 36 10 than than IN cord-335432-9aszklx3 36 11 a a DT cord-335432-9aszklx3 36 12 list list NN cord-335432-9aszklx3 36 13 of of IN cord-335432-9aszklx3 36 14 pathogens pathogen NNS cord-335432-9aszklx3 36 15 and and CC cord-335432-9aszklx3 36 16 illustrates illustrate VBZ cord-335432-9aszklx3 36 17 the the DT cord-335432-9aszklx3 36 18 broader broad JJR cord-335432-9aszklx3 36 19 impact impact NN cord-335432-9aszklx3 36 20 on on IN cord-335432-9aszklx3 36 21 microbiological microbiological JJ cord-335432-9aszklx3 36 22 research research NN cord-335432-9aszklx3 36 23 of of IN cord-335432-9aszklx3 36 24 this this DT cord-335432-9aszklx3 36 25 debate debate NN cord-335432-9aszklx3 36 26 . . . cord-335432-9aszklx3 37 1 Gain gain VB cord-335432-9aszklx3 37 2 - - HYPH cord-335432-9aszklx3 37 3 and and CC cord-335432-9aszklx3 37 4 loss loss NN cord-335432-9aszklx3 37 5 - - HYPH cord-335432-9aszklx3 37 6 of of IN cord-335432-9aszklx3 37 7 - - HYPH cord-335432-9aszklx3 37 8 function function NN cord-335432-9aszklx3 37 9 experiments experiment NNS cord-335432-9aszklx3 37 10 are be VBP cord-335432-9aszklx3 37 11 foundational foundational JJ cord-335432-9aszklx3 37 12 approaches approach NNS cord-335432-9aszklx3 37 13 of of IN cord-335432-9aszklx3 37 14 microbial microbial JJ cord-335432-9aszklx3 37 15 genetics genetic NNS cord-335432-9aszklx3 37 16 . . . cord-335432-9aszklx3 38 1 They -PRON- PRP cord-335432-9aszklx3 38 2 span span VBP cord-335432-9aszklx3 38 3 all all DT cord-335432-9aszklx3 38 4 of of IN cord-335432-9aszklx3 38 5 microbiology microbiology NN cord-335432-9aszklx3 38 6 , , , cord-335432-9aszklx3 38 7 not not RB cord-335432-9aszklx3 38 8 just just RB cord-335432-9aszklx3 38 9 the the DT cord-335432-9aszklx3 38 10 14 14 CD cord-335432-9aszklx3 38 11 pathogens pathogen NNS cord-335432-9aszklx3 38 12 on on IN cord-335432-9aszklx3 38 13 the the DT cord-335432-9aszklx3 38 14 DURC DURC NNP cord-335432-9aszklx3 38 15 list list NN cord-335432-9aszklx3 38 16 . . . cord-335432-9aszklx3 39 1 Selection selection NN cord-335432-9aszklx3 39 2 processes process NNS cord-335432-9aszklx3 39 3 are be VBP cord-335432-9aszklx3 39 4 used use VBN cord-335432-9aszklx3 39 5 to to TO cord-335432-9aszklx3 39 6 alter alter VB cord-335432-9aszklx3 39 7 wild wild JJ cord-335432-9aszklx3 39 8 - - HYPH cord-335432-9aszklx3 39 9 type type NN cord-335432-9aszklx3 39 10 phenotypes phenotype NNS cord-335432-9aszklx3 39 11 making make VBG cord-335432-9aszklx3 39 12 this this DT cord-335432-9aszklx3 39 13 word word NN cord-335432-9aszklx3 39 14 a a DT cord-335432-9aszklx3 39 15 more more RBR cord-335432-9aszklx3 39 16 appropriate appropriate JJ cord-335432-9aszklx3 39 17 descriptor descriptor NN cord-335432-9aszklx3 39 18 for for IN cord-335432-9aszklx3 39 19 any any DT cord-335432-9aszklx3 39 20 change change NN cord-335432-9aszklx3 39 21 in in IN cord-335432-9aszklx3 39 22 function function NN cord-335432-9aszklx3 39 23 . . . cord-335432-9aszklx3 40 1 It -PRON- PRP cord-335432-9aszklx3 40 2 covers cover VBZ cord-335432-9aszklx3 40 3 both both DT cord-335432-9aszklx3 40 4 loss loss NN cord-335432-9aszklx3 40 5 conducted conduct VBN cord-335432-9aszklx3 40 6 for for IN cord-335432-9aszklx3 40 7 legitimate legitimate JJ cord-335432-9aszklx3 40 8 purposes purpose NNS cord-335432-9aszklx3 40 9 that that WDT cord-335432-9aszklx3 40 10 generates generate VBZ cord-335432-9aszklx3 40 11 knowledge knowledge NN cord-335432-9aszklx3 40 12 , , , cord-335432-9aszklx3 40 13 information information NN cord-335432-9aszklx3 40 14 , , , cord-335432-9aszklx3 40 15 technologies technology NNS cord-335432-9aszklx3 40 16 , , , cord-335432-9aszklx3 40 17 and/or and/or CC cord-335432-9aszklx3 40 18 products product NNS cord-335432-9aszklx3 40 19 that that WDT cord-335432-9aszklx3 40 20 could could MD cord-335432-9aszklx3 40 21 be be VB cord-335432-9aszklx3 40 22 utilized utilize VBN cord-335432-9aszklx3 40 23 for for IN cord-335432-9aszklx3 40 24 both both CC cord-335432-9aszklx3 40 25 benevolent benevolent JJ cord-335432-9aszklx3 40 26 and and CC cord-335432-9aszklx3 40 27 harmful harmful JJ cord-335432-9aszklx3 40 28 purposes purpose NNS cord-335432-9aszklx3 40 29 . . . cord-335432-9aszklx3 41 1 ( ( -LRB- cord-335432-9aszklx3 41 2 B b NN cord-335432-9aszklx3 41 3 ) ) -RRB- cord-335432-9aszklx3 41 4 Dual dual JJ cord-335432-9aszklx3 41 5 - - HYPH cord-335432-9aszklx3 41 6 use use NN cord-335432-9aszklx3 41 7 research research NN cord-335432-9aszklx3 41 8 of of IN cord-335432-9aszklx3 41 9 concern concern NN cord-335432-9aszklx3 41 10 ( ( -LRB- cord-335432-9aszklx3 41 11 DURC DURC NNP cord-335432-9aszklx3 41 12 ) ) -RRB- cord-335432-9aszklx3 41 13 is be VBZ cord-335432-9aszklx3 41 14 a a DT cord-335432-9aszklx3 41 15 small small JJ cord-335432-9aszklx3 41 16 subset subset NN cord-335432-9aszklx3 41 17 of of IN cord-335432-9aszklx3 41 18 DUR DUR NNP cord-335432-9aszklx3 41 19 involving involve VBG cord-335432-9aszklx3 41 20 life life NN cord-335432-9aszklx3 41 21 sciences sciences NNPS cord-335432-9aszklx3 41 22 research research NN cord-335432-9aszklx3 41 23 that that IN cord-335432-9aszklx3 41 24 , , , cord-335432-9aszklx3 41 25 based base VBN cord-335432-9aszklx3 41 26 on on IN cord-335432-9aszklx3 41 27 current current JJ cord-335432-9aszklx3 41 28 understanding understanding NN cord-335432-9aszklx3 41 29 , , , cord-335432-9aszklx3 41 30 can can MD cord-335432-9aszklx3 41 31 reasonably reasonably RB cord-335432-9aszklx3 41 32 be be VB cord-335432-9aszklx3 41 33 anticipated anticipate VBN cord-335432-9aszklx3 41 34 to to TO cord-335432-9aszklx3 41 35 provide provide VB cord-335432-9aszklx3 41 36 knowledge knowledge NN cord-335432-9aszklx3 41 37 , , , cord-335432-9aszklx3 41 38 information information NN cord-335432-9aszklx3 41 39 , , , cord-335432-9aszklx3 41 40 products product NNS cord-335432-9aszklx3 41 41 , , , cord-335432-9aszklx3 41 42 or or CC cord-335432-9aszklx3 41 43 technologies technology NNS cord-335432-9aszklx3 41 44 that that WDT cord-335432-9aszklx3 41 45 could could MD cord-335432-9aszklx3 41 46 be be VB cord-335432-9aszklx3 41 47 directly directly RB cord-335432-9aszklx3 41 48 misapplied misapply VBN cord-335432-9aszklx3 41 49 , , , cord-335432-9aszklx3 41 50 posing pose VBG cord-335432-9aszklx3 41 51 a a DT cord-335432-9aszklx3 41 52 significant significant JJ cord-335432-9aszklx3 41 53 threat threat NN cord-335432-9aszklx3 41 54 with with IN cord-335432-9aszklx3 41 55 broad broad JJ cord-335432-9aszklx3 41 56 potential potential JJ cord-335432-9aszklx3 41 57 consequences consequence NNS cord-335432-9aszklx3 41 58 to to IN cord-335432-9aszklx3 41 59 public public JJ cord-335432-9aszklx3 41 60 health health NN cord-335432-9aszklx3 41 61 and and CC cord-335432-9aszklx3 41 62 safety safety NN cord-335432-9aszklx3 41 63 , , , cord-335432-9aszklx3 41 64 agricultural agricultural JJ cord-335432-9aszklx3 41 65 crops crop NNS cord-335432-9aszklx3 41 66 and and CC cord-335432-9aszklx3 41 67 other other JJ cord-335432-9aszklx3 41 68 plants plant NNS cord-335432-9aszklx3 41 69 , , , cord-335432-9aszklx3 41 70 animals animal NNS cord-335432-9aszklx3 41 71 , , , cord-335432-9aszklx3 41 72 the the DT cord-335432-9aszklx3 41 73 environment environment NN cord-335432-9aszklx3 41 74 , , , cord-335432-9aszklx3 41 75 materiel materiel NN cord-335432-9aszklx3 41 76 , , , cord-335432-9aszklx3 41 77 or or CC cord-335432-9aszklx3 41 78 national national JJ cord-335432-9aszklx3 41 79 security security NN cord-335432-9aszklx3 41 80 . . . cord-335432-9aszklx3 42 1 The the DT cord-335432-9aszklx3 42 2 15 15 CD cord-335432-9aszklx3 42 3 agents agent NNS cord-335432-9aszklx3 42 4 and and CC cord-335432-9aszklx3 42 5 toxins toxin NNS cord-335432-9aszklx3 42 6 listed list VBN cord-335432-9aszklx3 42 7 are be VBP cord-335432-9aszklx3 42 8 subject subject JJ cord-335432-9aszklx3 42 9 to to IN cord-335432-9aszklx3 42 10 select select JJ cord-335432-9aszklx3 42 11 - - HYPH cord-335432-9aszklx3 42 12 agent agent NN cord-335432-9aszklx3 42 13 regulations regulation NNS cord-335432-9aszklx3 42 14 . . . cord-335432-9aszklx3 43 1 ( ( -LRB- cord-335432-9aszklx3 43 2 C C NNP cord-335432-9aszklx3 43 3 ) ) -RRB- cord-335432-9aszklx3 44 1 The the DT cord-335432-9aszklx3 44 2 seven seven CD cord-335432-9aszklx3 44 3 viruses virus NNS cord-335432-9aszklx3 44 4 of of IN cord-335432-9aszklx3 44 5 concern concern NN cord-335432-9aszklx3 44 6 listed list VBN cord-335432-9aszklx3 44 7 include include VBP cord-335432-9aszklx3 44 8 circulating circulate VBG cord-335432-9aszklx3 44 9 , , , cord-335432-9aszklx3 44 10 synthetically synthetically RB cord-335432-9aszklx3 44 11 generated generate VBN cord-335432-9aszklx3 44 12 , , , cord-335432-9aszklx3 44 13 and and CC cord-335432-9aszklx3 44 14 eradicated eradicate VBD cord-335432-9aszklx3 44 15 agents agent NNS cord-335432-9aszklx3 44 16 . . . cord-335432-9aszklx3 45 1 ( ( -LRB- cord-335432-9aszklx3 45 2 D d NN cord-335432-9aszklx3 45 3 ) ) -RRB- cord-335432-9aszklx3 46 1 Although although IN cord-335432-9aszklx3 46 2 spanning span VBG cord-335432-9aszklx3 46 3 all all DT cord-335432-9aszklx3 46 4 of of IN cord-335432-9aszklx3 46 5 microbiological microbiological JJ cord-335432-9aszklx3 46 6 research research NN cord-335432-9aszklx3 46 7 , , , cord-335432-9aszklx3 46 8 much much JJ cord-335432-9aszklx3 46 9 of of IN cord-335432-9aszklx3 46 10 the the DT cord-335432-9aszklx3 46 11 DURC DURC NNP cord-335432-9aszklx3 46 12 debate debate NN cord-335432-9aszklx3 46 13 has have VBZ cord-335432-9aszklx3 46 14 focused focus VBN cord-335432-9aszklx3 46 15 on on IN cord-335432-9aszklx3 46 16 virology virology NN cord-335432-9aszklx3 46 17 , , , cord-335432-9aszklx3 46 18 where where WRB cord-335432-9aszklx3 46 19 selection selection NN cord-335432-9aszklx3 46 20 processes process NNS cord-335432-9aszklx3 46 21 of of IN cord-335432-9aszklx3 46 22 circulating circulate VBG cord-335432-9aszklx3 46 23 and and CC cord-335432-9aszklx3 46 24 synthetically synthetically RB cord-335432-9aszklx3 46 25 generated generate VBN cord-335432-9aszklx3 46 26 agents agent NNS cord-335432-9aszklx3 46 27 have have VBP cord-335432-9aszklx3 46 28 been be VBN cord-335432-9aszklx3 46 29 used use VBN cord-335432-9aszklx3 46 30 to to TO cord-335432-9aszklx3 46 31 enhance enhance VB cord-335432-9aszklx3 46 32 transmission transmission NN cord-335432-9aszklx3 46 33 . . . cord-335432-9aszklx3 47 1 Although although IN cord-335432-9aszklx3 47 2 selection selection NN cord-335432-9aszklx3 47 3 is be VBZ cord-335432-9aszklx3 47 4 a a DT cord-335432-9aszklx3 47 5 mainstay mainstay NN cord-335432-9aszklx3 47 6 of of IN cord-335432-9aszklx3 47 7 microbial microbial JJ cord-335432-9aszklx3 47 8 genetic genetic JJ cord-335432-9aszklx3 47 9 research research NN cord-335432-9aszklx3 47 10 and and CC cord-335432-9aszklx3 47 11 gain gain NN cord-335432-9aszklx3 47 12 ( ( -LRB- cord-335432-9aszklx3 47 13 green green JJ cord-335432-9aszklx3 47 14 shading)and shading)and CC cord-335432-9aszklx3 47 15 loss loss NN cord-335432-9aszklx3 47 16 ( ( -LRB- cord-335432-9aszklx3 47 17 red red JJ cord-335432-9aszklx3 47 18 shading)-of shading)-of NN cord-335432-9aszklx3 47 19 - - HYPH cord-335432-9aszklx3 47 20 function function NN cord-335432-9aszklx3 47 21 experiments experiment NNS cord-335432-9aszklx3 47 22 are be VBP cord-335432-9aszklx3 47 23 commonplace commonplace JJ cord-335432-9aszklx3 47 24 if if IN cord-335432-9aszklx3 47 25 the the DT cord-335432-9aszklx3 47 26 DURC DURC NNP cord-335432-9aszklx3 47 27 list list NN cord-335432-9aszklx3 47 28 is be VBZ cord-335432-9aszklx3 47 29 strictly strictly RB cord-335432-9aszklx3 47 30 adhered adhere VBN cord-335432-9aszklx3 47 31 to to IN cord-335432-9aszklx3 47 32 , , , cord-335432-9aszklx3 47 33 there there EX cord-335432-9aszklx3 47 34 is be VBZ cord-335432-9aszklx3 47 35 a a DT cord-335432-9aszklx3 47 36 very very RB cord-335432-9aszklx3 47 37 small small JJ cord-335432-9aszklx3 47 38 number number NN cord-335432-9aszklx3 47 39 of of IN cord-335432-9aszklx3 47 40 DURC DURC NNP cord-335432-9aszklx3 47 41 projects project NNS cord-335432-9aszklx3 47 42 ( ( -LRB- cord-335432-9aszklx3 47 43 red red JJ cord-335432-9aszklx3 47 44 circle circle NN cord-335432-9aszklx3 47 45 ) ) -RRB- cord-335432-9aszklx3 47 46 . . . cord-335432-9aszklx3 48 1 Furthermore furthermore RB cord-335432-9aszklx3 48 2 , , , cord-335432-9aszklx3 48 3 gain gain NN cord-335432-9aszklx3 48 4 of of IN cord-335432-9aszklx3 48 5 function function NN cord-335432-9aszklx3 48 6 is be VBZ cord-335432-9aszklx3 48 7 often often RB cord-335432-9aszklx3 48 8 accompanied accompany VBN cord-335432-9aszklx3 48 9 by by IN cord-335432-9aszklx3 48 10 loss loss NN cord-335432-9aszklx3 48 11 of of IN cord-335432-9aszklx3 48 12 function function NN cord-335432-9aszklx3 48 13 and and CC cord-335432-9aszklx3 48 14 vice vice NN cord-335432-9aszklx3 48 15 versa versa RB cord-335432-9aszklx3 48 16 ( ( -LRB- cord-335432-9aszklx3 48 17 yellow yellow JJ cord-335432-9aszklx3 48 18 shading shading NN cord-335432-9aszklx3 48 19 ) ) -RRB- cord-335432-9aszklx3 48 20 . . . cord-335432-9aszklx3 49 1 ( ( -LRB- cord-335432-9aszklx3 49 2 E e NN cord-335432-9aszklx3 49 3 ) ) -RRB- cord-335432-9aszklx3 49 4 Alterations alteration NNS cord-335432-9aszklx3 49 5 in in IN cord-335432-9aszklx3 49 6 phenotype phenotype NN cord-335432-9aszklx3 49 7 which which WDT cord-335432-9aszklx3 49 8 give give VBP cord-335432-9aszklx3 49 9 cause cause NN cord-335432-9aszklx3 49 10 of of IN cord-335432-9aszklx3 49 11 concern concern NN cord-335432-9aszklx3 49 12 can can MD cord-335432-9aszklx3 49 13 include include VB cord-335432-9aszklx3 49 14 loss loss NN cord-335432-9aszklx3 49 15 and and CC cord-335432-9aszklx3 49 16 gain gain NN cord-335432-9aszklx3 49 17 of of IN cord-335432-9aszklx3 49 18 function function NN cord-335432-9aszklx3 49 19 . . . cord-335432-9aszklx3 50 1 Editorial editorial NN cord-335432-9aszklx3 50 2 and and CC cord-335432-9aszklx3 50 3 gain gain NN cord-335432-9aszklx3 50 4 and and CC cord-335432-9aszklx3 50 5 recognizes recognize VBZ cord-335432-9aszklx3 50 6 an an DT cord-335432-9aszklx3 50 7 important important JJ cord-335432-9aszklx3 50 8 part part NN cord-335432-9aszklx3 50 9 of of IN cord-335432-9aszklx3 50 10 any any DT cord-335432-9aszklx3 50 11 selection selection NN cord-335432-9aszklx3 50 12 process process NN cord-335432-9aszklx3 50 13 ; ; : cord-335432-9aszklx3 50 14 there there EX cord-335432-9aszklx3 50 15 is be VBZ cord-335432-9aszklx3 50 16 often often RB cord-335432-9aszklx3 50 17 a a DT cord-335432-9aszklx3 50 18 trade trade NN cord-335432-9aszklx3 50 19 - - HYPH cord-335432-9aszklx3 50 20 off off NN cord-335432-9aszklx3 50 21 such such JJ cord-335432-9aszklx3 50 22 that that IN cord-335432-9aszklx3 50 23 as as IN cord-335432-9aszklx3 50 24 one one CD cord-335432-9aszklx3 50 25 function function NN cord-335432-9aszklx3 50 26 is be VBZ cord-335432-9aszklx3 50 27 acquired acquire VBN cord-335432-9aszklx3 50 28 or or CC cord-335432-9aszklx3 50 29 enhanced enhance VBN cord-335432-9aszklx3 50 30 , , , cord-335432-9aszklx3 50 31 another another DT cord-335432-9aszklx3 50 32 function function NN cord-335432-9aszklx3 50 33 is be VBZ cord-335432-9aszklx3 50 34 concomitantly concomitantly RB cord-335432-9aszklx3 50 35 lost lose VBN cord-335432-9aszklx3 50 36 or or CC cord-335432-9aszklx3 50 37 reduced reduce VBN cord-335432-9aszklx3 50 38 . . . cord-335432-9aszklx3 51 1 This this DT cord-335432-9aszklx3 51 2 is be VBZ cord-335432-9aszklx3 51 3 illustrated illustrate VBN cord-335432-9aszklx3 51 4 for for IN cord-335432-9aszklx3 51 5 all all DT cord-335432-9aszklx3 51 6 of of IN cord-335432-9aszklx3 51 7 virology virology NN cord-335432-9aszklx3 51 8 ( ( -LRB- cord-335432-9aszklx3 51 9 Fig Fig NNP cord-335432-9aszklx3 51 10 . . . cord-335432-9aszklx3 51 11 1D 1d CD cord-335432-9aszklx3 51 12 ) ) -RRB- cord-335432-9aszklx3 51 13 . . . cord-335432-9aszklx3 52 1 For for IN cord-335432-9aszklx3 52 2 example example NN cord-335432-9aszklx3 52 3 , , , cord-335432-9aszklx3 52 4 a a DT cord-335432-9aszklx3 52 5 human human JJ cord-335432-9aszklx3 52 6 virus virus NN cord-335432-9aszklx3 52 7 passaged passage VBN cord-335432-9aszklx3 52 8 in in IN cord-335432-9aszklx3 52 9 animal animal NN cord-335432-9aszklx3 52 10 cells cell NNS cord-335432-9aszklx3 52 11 can can MD cord-335432-9aszklx3 52 12 adapt adapt VB cord-335432-9aszklx3 52 13 to to IN cord-335432-9aszklx3 52 14 a a DT cord-335432-9aszklx3 52 15 different different JJ cord-335432-9aszklx3 52 16 receptor receptor NN cord-335432-9aszklx3 52 17 and/or and/or CC cord-335432-9aszklx3 52 18 intracellular intracellular JJ cord-335432-9aszklx3 52 19 factors factor NNS cord-335432-9aszklx3 52 20 and and CC cord-335432-9aszklx3 52 21 can can MD cord-335432-9aszklx3 52 22 infect infect VB cord-335432-9aszklx3 52 23 more more JJR cord-335432-9aszklx3 52 24 cell cell NN cord-335432-9aszklx3 52 25 types type NNS cord-335432-9aszklx3 52 26 than than IN cord-335432-9aszklx3 52 27 the the DT cord-335432-9aszklx3 52 28 wild wild JJ cord-335432-9aszklx3 52 29 - - HYPH cord-335432-9aszklx3 52 30 type type NN cord-335432-9aszklx3 52 31 virus virus NN cord-335432-9aszklx3 52 32 ( ( -LRB- cord-335432-9aszklx3 52 33 gain gain NN cord-335432-9aszklx3 52 34 of of IN cord-335432-9aszklx3 52 35 function function NN cord-335432-9aszklx3 52 36 ) ) -RRB- cord-335432-9aszklx3 52 37 . . . cord-335432-9aszklx3 53 1 However however RB cord-335432-9aszklx3 53 2 , , , cord-335432-9aszklx3 53 3 these these DT cord-335432-9aszklx3 53 4 and and CC cord-335432-9aszklx3 53 5 other other JJ cord-335432-9aszklx3 53 6 adaptive adaptive JJ cord-335432-9aszklx3 53 7 mutations mutation NNS cord-335432-9aszklx3 53 8 can can MD cord-335432-9aszklx3 53 9 lead lead VB cord-335432-9aszklx3 53 10 to to IN cord-335432-9aszklx3 53 11 a a DT cord-335432-9aszklx3 53 12 decrease decrease NN cord-335432-9aszklx3 53 13 in in IN cord-335432-9aszklx3 53 14 virulence virulence NN cord-335432-9aszklx3 53 15 as as IN cord-335432-9aszklx3 53 16 the the DT cord-335432-9aszklx3 53 17 process process NN cord-335432-9aszklx3 53 18 of of IN cord-335432-9aszklx3 53 19 pathogenesis pathogenesis NN cord-335432-9aszklx3 53 20 is be VBZ cord-335432-9aszklx3 53 21 altered alter VBN cord-335432-9aszklx3 53 22 ( ( -LRB- cord-335432-9aszklx3 53 23 loss loss NN cord-335432-9aszklx3 53 24 of of IN cord-335432-9aszklx3 53 25 function function NN cord-335432-9aszklx3 53 26 ) ) -RRB- cord-335432-9aszklx3 53 27 . . . cord-335432-9aszklx3 54 1 Live live JJ cord-335432-9aszklx3 54 2 attenuated attenuated JJ cord-335432-9aszklx3 54 3 vaccines vaccine NNS cord-335432-9aszklx3 54 4 can can MD cord-335432-9aszklx3 54 5 be be VB cord-335432-9aszklx3 54 6 placed place VBN cord-335432-9aszklx3 54 7 in in IN cord-335432-9aszklx3 54 8 the the DT cord-335432-9aszklx3 54 9 yellow yellow JJ cord-335432-9aszklx3 54 10 section section NN cord-335432-9aszklx3 54 11 , , , cord-335432-9aszklx3 54 12 as as IN cord-335432-9aszklx3 54 13 by by IN cord-335432-9aszklx3 54 14 definition definition NN cord-335432-9aszklx3 54 15 a a DT cord-335432-9aszklx3 54 16 key key JJ cord-335432-9aszklx3 54 17 goal goal NN cord-335432-9aszklx3 54 18 of of IN cord-335432-9aszklx3 54 19 the the DT cord-335432-9aszklx3 54 20 selection selection NN cord-335432-9aszklx3 54 21 process process NN cord-335432-9aszklx3 54 22 is be VBZ cord-335432-9aszklx3 54 23 loss loss NN cord-335432-9aszklx3 54 24 of of IN cord-335432-9aszklx3 54 25 virulence virulence NN cord-335432-9aszklx3 54 26 , , , cord-335432-9aszklx3 54 27 but but CC cord-335432-9aszklx3 54 28 a a DT cord-335432-9aszklx3 54 29 consequence consequence NN cord-335432-9aszklx3 54 30 of of IN cord-335432-9aszklx3 54 31 passage passage NN cord-335432-9aszklx3 54 32 is be VBZ cord-335432-9aszklx3 54 33 a a DT cord-335432-9aszklx3 54 34 gain gain NN cord-335432-9aszklx3 54 35 of of IN cord-335432-9aszklx3 54 36 infectivity infectivity NN cord-335432-9aszklx3 54 37 and and CC cord-335432-9aszklx3 54 38 a a DT cord-335432-9aszklx3 54 39 change change NN cord-335432-9aszklx3 54 40 in in IN cord-335432-9aszklx3 54 41 tropism tropism NN cord-335432-9aszklx3 54 42 . . . cord-335432-9aszklx3 55 1 This this DT cord-335432-9aszklx3 55 2 example example NN cord-335432-9aszklx3 55 3 illustrates illustrate VBZ cord-335432-9aszklx3 55 4 the the DT cord-335432-9aszklx3 55 5 fundamental fundamental JJ cord-335432-9aszklx3 55 6 problem problem NN cord-335432-9aszklx3 55 7 of of IN cord-335432-9aszklx3 55 8 focusing focus VBG cord-335432-9aszklx3 55 9 exclusively exclusively RB cord-335432-9aszklx3 55 10 on on IN cord-335432-9aszklx3 55 11 one one CD cord-335432-9aszklx3 55 12 function function NN cord-335432-9aszklx3 55 13 and and CC cord-335432-9aszklx3 55 14 one one CD cord-335432-9aszklx3 55 15 virus virus NN cord-335432-9aszklx3 55 16 . . . cord-335432-9aszklx3 56 1 Most Most JJS cord-335432-9aszklx3 56 2 of of IN cord-335432-9aszklx3 56 3 the the DT cord-335432-9aszklx3 56 4 discussion discussion NN cord-335432-9aszklx3 56 5 has have VBZ cord-335432-9aszklx3 56 6 centered center VBN cord-335432-9aszklx3 56 7 on on IN cord-335432-9aszklx3 56 8 the the DT cord-335432-9aszklx3 56 9 gain gain NN cord-335432-9aszklx3 56 10 of of IN cord-335432-9aszklx3 56 11 transmission transmission NN cord-335432-9aszklx3 56 12 of of IN cord-335432-9aszklx3 56 13 influenza influenza NN cord-335432-9aszklx3 56 14 leading lead VBG cord-335432-9aszklx3 56 15 to to IN cord-335432-9aszklx3 56 16 a a DT cord-335432-9aszklx3 56 17 situation situation NN cord-335432-9aszklx3 56 18 where where WRB cord-335432-9aszklx3 56 19 the the DT cord-335432-9aszklx3 56 20 proverbial proverbial JJ cord-335432-9aszklx3 56 21 " " `` cord-335432-9aszklx3 56 22 tail tail NN cord-335432-9aszklx3 56 23 is be VBZ cord-335432-9aszklx3 56 24 wagging wag VBG cord-335432-9aszklx3 56 25 the the DT cord-335432-9aszklx3 56 26 dog dog NN cord-335432-9aszklx3 56 27 . . . cord-335432-9aszklx3 57 1 " " `` cord-335432-9aszklx3 57 2 This this DT cord-335432-9aszklx3 57 3 is be VBZ cord-335432-9aszklx3 57 4 why why WRB cord-335432-9aszklx3 57 5 we -PRON- PRP cord-335432-9aszklx3 57 6 need need VBP cord-335432-9aszklx3 57 7 to to TO cord-335432-9aszklx3 57 8 define define VB cord-335432-9aszklx3 57 9 not not RB cord-335432-9aszklx3 57 10 just just RB cord-335432-9aszklx3 57 11 one one CD cord-335432-9aszklx3 57 12 but but CC cord-335432-9aszklx3 57 13 all all DT cord-335432-9aszklx3 57 14 of of IN cord-335432-9aszklx3 57 15 the the DT cord-335432-9aszklx3 57 16 " " `` cord-335432-9aszklx3 57 17 F F NNP cord-335432-9aszklx3 57 18 's 's POS cord-335432-9aszklx3 57 19 . . . cord-335432-9aszklx3 57 20 " " '' cord-335432-9aszklx3 58 1 Accepting accept VBG cord-335432-9aszklx3 58 2 that that IN cord-335432-9aszklx3 58 3 a a DT cord-335432-9aszklx3 58 4 selection selection NN cord-335432-9aszklx3 58 5 process process NN cord-335432-9aszklx3 58 6 leads lead VBZ cord-335432-9aszklx3 58 7 to to IN cord-335432-9aszklx3 58 8 an an DT cord-335432-9aszklx3 58 9 alteration alteration NN cord-335432-9aszklx3 58 10 in in IN cord-335432-9aszklx3 58 11 phenotype phenotype NN cord-335432-9aszklx3 58 12 and and CC cord-335432-9aszklx3 58 13 produces produce VBZ cord-335432-9aszklx3 58 14 a a DT cord-335432-9aszklx3 58 15 pathogen pathogen NN cord-335432-9aszklx3 58 16 with with IN cord-335432-9aszklx3 58 17 different different JJ cord-335432-9aszklx3 58 18 functions function NNS cord-335432-9aszklx3 58 19 is be VBZ cord-335432-9aszklx3 58 20 straightforward straightforward JJ cord-335432-9aszklx3 58 21 , , , cord-335432-9aszklx3 58 22 as as IN cord-335432-9aszklx3 58 23 this this DT cord-335432-9aszklx3 58 24 is be VBZ cord-335432-9aszklx3 58 25 a a DT cord-335432-9aszklx3 58 26 common common JJ cord-335432-9aszklx3 58 27 approach approach NN cord-335432-9aszklx3 58 28 in in IN cord-335432-9aszklx3 58 29 microbiology microbiology NN cord-335432-9aszklx3 58 30 . . . cord-335432-9aszklx3 59 1 Agreeing agree VBG cord-335432-9aszklx3 59 2 which which WDT cord-335432-9aszklx3 59 3 functions function VBZ cord-335432-9aszklx3 59 4 to to TO cord-335432-9aszklx3 59 5 focus focus VB cord-335432-9aszklx3 59 6 on on IN cord-335432-9aszklx3 59 7 is be VBZ cord-335432-9aszklx3 59 8 also also RB cord-335432-9aszklx3 59 9 relatively relatively RB cord-335432-9aszklx3 59 10 easy easy JJ cord-335432-9aszklx3 59 11 , , , cord-335432-9aszklx3 59 12 as as IN cord-335432-9aszklx3 59 13 the the DT cord-335432-9aszklx3 59 14 DURC DURC NNP cord-335432-9aszklx3 59 15 policy policy NN cord-335432-9aszklx3 59 16 is be VBZ cord-335432-9aszklx3 59 17 clear clear JJ cord-335432-9aszklx3 59 18 . . . cord-335432-9aszklx3 60 1 From from IN cord-335432-9aszklx3 60 2 the the DT cord-335432-9aszklx3 60 3 seven seven CD cord-335432-9aszklx3 60 4 categories category NNS cord-335432-9aszklx3 60 5 of of IN cord-335432-9aszklx3 60 6 experiments experiment NNS cord-335432-9aszklx3 60 7 requiring require VBG cord-335432-9aszklx3 60 8 oversight oversight NN cord-335432-9aszklx3 60 9 , , , cord-335432-9aszklx3 60 10 six six CD cord-335432-9aszklx3 60 11 identify identify NN cord-335432-9aszklx3 60 12 functions function NNS cord-335432-9aszklx3 60 13 of of IN cord-335432-9aszklx3 60 14 concern concern NN cord-335432-9aszklx3 60 15 and and CC cord-335432-9aszklx3 60 16 one one NN cord-335432-9aszklx3 60 17 focuses focus VBZ cord-335432-9aszklx3 60 18 on on IN cord-335432-9aszklx3 60 19 ( ( -LRB- cord-335432-9aszklx3 60 20 i i NN cord-335432-9aszklx3 60 21 ) ) -RRB- cord-335432-9aszklx3 60 22 reconstructing reconstruct VBG cord-335432-9aszklx3 60 23 pathogens pathogen NNS cord-335432-9aszklx3 60 24 which which WDT cord-335432-9aszklx3 60 25 have have VBP cord-335432-9aszklx3 60 26 been be VBN cord-335432-9aszklx3 60 27 eradicated eradicate VBN cord-335432-9aszklx3 60 28 or or CC cord-335432-9aszklx3 60 29 ( ( -LRB- cord-335432-9aszklx3 60 30 ii ii NN cord-335432-9aszklx3 60 31 ) ) -RRB- cord-335432-9aszklx3 60 32 reconstituting reconstitute VBG cord-335432-9aszklx3 60 33 viruses virus NNS cord-335432-9aszklx3 60 34 no no RB cord-335432-9aszklx3 60 35 longer long RBR cord-335432-9aszklx3 60 36 in in IN cord-335432-9aszklx3 60 37 general general JJ cord-335432-9aszklx3 60 38 circulation circulation NN cord-335432-9aszklx3 60 39 . . . cord-335432-9aszklx3 61 1 Synthetic synthetic JJ cord-335432-9aszklx3 61 2 reconstruction reconstruction NN cord-335432-9aszklx3 61 3 from from IN cord-335432-9aszklx3 61 4 published publish VBN cord-335432-9aszklx3 61 5 sequences sequence NNS cord-335432-9aszklx3 61 6 or or CC cord-335432-9aszklx3 61 7 reconstitution reconstitution NN cord-335432-9aszklx3 61 8 from from IN cord-335432-9aszklx3 61 9 archived archived JJ cord-335432-9aszklx3 61 10 clinical clinical JJ cord-335432-9aszklx3 61 11 samples sample NNS cord-335432-9aszklx3 61 12 is be VBZ cord-335432-9aszklx3 61 13 simple simple JJ cord-335432-9aszklx3 61 14 to to TO cord-335432-9aszklx3 61 15 regulate regulate VB cord-335432-9aszklx3 61 16 at at IN cord-335432-9aszklx3 61 17 the the DT cord-335432-9aszklx3 61 18 level level NN cord-335432-9aszklx3 61 19 of of IN cord-335432-9aszklx3 61 20 an an DT cord-335432-9aszklx3 61 21 institutional institutional JJ cord-335432-9aszklx3 61 22 biosafety biosafety NN cord-335432-9aszklx3 61 23 committee committee NN cord-335432-9aszklx3 61 24 ( ( -LRB- cord-335432-9aszklx3 61 25 IBC IBC NNP cord-335432-9aszklx3 61 26 ) ) -RRB- cord-335432-9aszklx3 61 27 or or CC cord-335432-9aszklx3 61 28 institutional institutional JJ cord-335432-9aszklx3 61 29 review review NN cord-335432-9aszklx3 61 30 entity entity NN cord-335432-9aszklx3 61 31 ( ( -LRB- cord-335432-9aszklx3 61 32 IRE ire NN cord-335432-9aszklx3 61 33 ) ) -RRB- cord-335432-9aszklx3 61 34 . . . cord-335432-9aszklx3 62 1 It -PRON- PRP cord-335432-9aszklx3 62 2 is be VBZ cord-335432-9aszklx3 62 3 expected expect VBN cord-335432-9aszklx3 62 4 that that IN cord-335432-9aszklx3 62 5 any any DT cord-335432-9aszklx3 62 6 such such JJ cord-335432-9aszklx3 62 7 body body NN cord-335432-9aszklx3 62 8 would would MD cord-335432-9aszklx3 62 9 point point VB cord-335432-9aszklx3 62 10 out out RP cord-335432-9aszklx3 62 11 that that IN cord-335432-9aszklx3 62 12 work work NN cord-335432-9aszklx3 62 13 with with IN cord-335432-9aszklx3 62 14 rinderpest rinderpest NN cord-335432-9aszklx3 62 15 or or CC cord-335432-9aszklx3 62 16 smallpox smallpox NN cord-335432-9aszklx3 62 17 virus virus NN cord-335432-9aszklx3 62 18 as as IN cord-335432-9aszklx3 62 19 part part NN cord-335432-9aszklx3 62 20 of of IN cord-335432-9aszklx3 62 21 an an DT cord-335432-9aszklx3 62 22 NIH NIH NNP cord-335432-9aszklx3 62 23 application application NN cord-335432-9aszklx3 62 24 is be VBZ cord-335432-9aszklx3 62 25 not not RB cord-335432-9aszklx3 62 26 permissible permissible JJ cord-335432-9aszklx3 62 27 . . . cord-335432-9aszklx3 63 1 However however RB cord-335432-9aszklx3 63 2 , , , cord-335432-9aszklx3 63 3 more more JJR cord-335432-9aszklx3 63 4 in in IN cord-335432-9aszklx3 63 5 - - HYPH cord-335432-9aszklx3 63 6 depth depth NN cord-335432-9aszklx3 63 7 discussions discussion NNS cord-335432-9aszklx3 63 8 are be VBP cord-335432-9aszklx3 63 9 required require VBN cord-335432-9aszklx3 63 10 between between IN cord-335432-9aszklx3 63 11 review review NN cord-335432-9aszklx3 63 12 committees committee NNS cord-335432-9aszklx3 63 13 and and CC cord-335432-9aszklx3 63 14 a a DT cord-335432-9aszklx3 63 15 researcher researcher NN cord-335432-9aszklx3 63 16 who who WP cord-335432-9aszklx3 63 17 seeks seek VBZ cord-335432-9aszklx3 63 18 permission permission NN cord-335432-9aszklx3 63 19 to to TO cord-335432-9aszklx3 63 20 perform perform VB cord-335432-9aszklx3 63 21 microbiological microbiological JJ cord-335432-9aszklx3 63 22 experiments experiment NNS cord-335432-9aszklx3 63 23 which which WDT cord-335432-9aszklx3 63 24 aim aim VBP cord-335432-9aszklx3 63 25 to to TO cord-335432-9aszklx3 63 26 alter alter VB cord-335432-9aszklx3 63 27 one one CD cord-335432-9aszklx3 63 28 or or CC cord-335432-9aszklx3 63 29 more more JJR cord-335432-9aszklx3 63 30 of of IN cord-335432-9aszklx3 63 31 the the DT cord-335432-9aszklx3 63 32 six six CD cord-335432-9aszklx3 63 33 functions function NNS cord-335432-9aszklx3 63 34 of of IN cord-335432-9aszklx3 63 35 concern concern NN cord-335432-9aszklx3 63 36 . . . cord-335432-9aszklx3 64 1 Increases increase NNS cord-335432-9aszklx3 64 2 in in IN cord-335432-9aszklx3 64 3 transmission transmission NN cord-335432-9aszklx3 64 4 , , , cord-335432-9aszklx3 64 5 range range NN cord-335432-9aszklx3 64 6 , , , cord-335432-9aszklx3 64 7 infectivity infectivity NN cord-335432-9aszklx3 64 8 , , , cord-335432-9aszklx3 64 9 pathogenesis pathogenesis NN cord-335432-9aszklx3 64 10 , , , cord-335432-9aszklx3 64 11 resistance resistance NN cord-335432-9aszklx3 64 12 to to IN cord-335432-9aszklx3 64 13 a a DT cord-335432-9aszklx3 64 14 therapeutic therapeutic JJ cord-335432-9aszklx3 64 15 agent agent NN cord-335432-9aszklx3 64 16 , , , cord-335432-9aszklx3 64 17 and and CC cord-335432-9aszklx3 64 18 disruption disruption NN cord-335432-9aszklx3 64 19 of of IN cord-335432-9aszklx3 64 20 immunity immunity NN cord-335432-9aszklx3 64 21 are be VBP cord-335432-9aszklx3 64 22 the the DT cord-335432-9aszklx3 64 23 functions function NNS cord-335432-9aszklx3 64 24 which which WDT cord-335432-9aszklx3 64 25 demand demand VBP cord-335432-9aszklx3 64 26 attention attention NN cord-335432-9aszklx3 64 27 ( ( -LRB- cord-335432-9aszklx3 64 28 Fig Fig NNP cord-335432-9aszklx3 64 29 . . . cord-335432-9aszklx3 64 30 1E 1E NNP cord-335432-9aszklx3 64 31 ) ) -RRB- cord-335432-9aszklx3 64 32 . . . cord-335432-9aszklx3 65 1 For for IN cord-335432-9aszklx3 65 2 some some DT cord-335432-9aszklx3 65 3 , , , cord-335432-9aszklx3 65 4 gain gain NN cord-335432-9aszklx3 65 5 of of IN cord-335432-9aszklx3 65 6 function function NN cord-335432-9aszklx3 65 7 causes cause VBZ cord-335432-9aszklx3 65 8 the the DT cord-335432-9aszklx3 65 9 most most JJS cord-335432-9aszklx3 65 10 concern concern NN cord-335432-9aszklx3 65 11 , , , cord-335432-9aszklx3 65 12 although although IN cord-335432-9aszklx3 65 13 even even RB cord-335432-9aszklx3 65 14 for for IN cord-335432-9aszklx3 65 15 the the DT cord-335432-9aszklx3 65 16 influenza influenza NN cord-335432-9aszklx3 65 17 transmission transmission NN cord-335432-9aszklx3 65 18 studies study NNS cord-335432-9aszklx3 65 19 , , , cord-335432-9aszklx3 65 20 it -PRON- PRP cord-335432-9aszklx3 65 21 is be VBZ cord-335432-9aszklx3 65 22 simplistic simplistic JJ cord-335432-9aszklx3 65 23 to to TO cord-335432-9aszklx3 65 24 focus focus VB cord-335432-9aszklx3 65 25 on on IN cord-335432-9aszklx3 65 26 only only RB cord-335432-9aszklx3 65 27 one one CD cord-335432-9aszklx3 65 28 phenotype/ phenotype/ CD cord-335432-9aszklx3 65 29 one one CD cord-335432-9aszklx3 65 30 function function NN cord-335432-9aszklx3 65 31 as as IN cord-335432-9aszklx3 65 32 a a DT cord-335432-9aszklx3 65 33 range range NN cord-335432-9aszklx3 65 34 or or CC cord-335432-9aszklx3 65 35 on on IN cord-335432-9aszklx3 65 36 infectivity infectivity NN cord-335432-9aszklx3 65 37 changed change VBN cord-335432-9aszklx3 65 38 during during IN cord-335432-9aszklx3 65 39 selection selection NN cord-335432-9aszklx3 65 40 of of IN cord-335432-9aszklx3 65 41 mammal mammal NN cord-335432-9aszklx3 65 42 - - HYPH cord-335432-9aszklx3 65 43 adapted adapt VBN cord-335432-9aszklx3 65 44 avian avian JJ cord-335432-9aszklx3 65 45 influenza influenza NN cord-335432-9aszklx3 65 46 viruses virus NNS cord-335432-9aszklx3 65 47 . . . cord-335432-9aszklx3 66 1 Once once RB cord-335432-9aszklx3 66 2 again again RB cord-335432-9aszklx3 66 3 , , , cord-335432-9aszklx3 66 4 this this DT cord-335432-9aszklx3 66 5 highlights highlight VBZ cord-335432-9aszklx3 66 6 why why WRB cord-335432-9aszklx3 66 7 " " `` cord-335432-9aszklx3 66 8 GOF GOF NNP cord-335432-9aszklx3 66 9 " " '' cord-335432-9aszklx3 66 10 is be VBZ cord-335432-9aszklx3 66 11 such such PDT cord-335432-9aszklx3 66 12 a a DT cord-335432-9aszklx3 66 13 vague vague JJ cord-335432-9aszklx3 66 14 term term NN cord-335432-9aszklx3 66 15 . . . cord-335432-9aszklx3 67 1 Conversely conversely RB cord-335432-9aszklx3 67 2 , , , cord-335432-9aszklx3 67 3 loss loss NN cord-335432-9aszklx3 67 4 of of IN cord-335432-9aszklx3 67 5 function function NN cord-335432-9aszklx3 67 6 , , , cord-335432-9aszklx3 67 7 such such JJ cord-335432-9aszklx3 67 8 as as IN cord-335432-9aszklx3 67 9 the the DT cord-335432-9aszklx3 67 10 ability ability NN cord-335432-9aszklx3 67 11 to to TO cord-335432-9aszklx3 67 12 be be VB cord-335432-9aszklx3 67 13 neutralized neutralize VBN cord-335432-9aszklx3 67 14 by by IN cord-335432-9aszklx3 67 15 an an DT cord-335432-9aszklx3 67 16 antibody antibody NN cord-335432-9aszklx3 67 17 , , , cord-335432-9aszklx3 67 18 inhibited inhibit VBN cord-335432-9aszklx3 67 19 by by IN cord-335432-9aszklx3 67 20 a a DT cord-335432-9aszklx3 67 21 drug drug NN cord-335432-9aszklx3 67 22 , , , cord-335432-9aszklx3 67 23 or or CC cord-335432-9aszklx3 67 24 detected detect VBN cord-335432-9aszklx3 67 25 by by IN cord-335432-9aszklx3 67 26 a a DT cord-335432-9aszklx3 67 27 diagnostic diagnostic JJ cord-335432-9aszklx3 67 28 assay assay NN cord-335432-9aszklx3 67 29 , , , cord-335432-9aszklx3 67 30 also also RB cord-335432-9aszklx3 67 31 raises raise VBZ cord-335432-9aszklx3 67 32 significant significant JJ cord-335432-9aszklx3 67 33 concern concern NN cord-335432-9aszklx3 67 34 . . . cord-335432-9aszklx3 68 1 An an DT cord-335432-9aszklx3 68 2 experiment experiment NN cord-335432-9aszklx3 68 3 that that WDT cord-335432-9aszklx3 68 4 uses use VBZ cord-335432-9aszklx3 68 5 one one CD cord-335432-9aszklx3 68 6 or or CC cord-335432-9aszklx3 68 7 more more JJR cord-335432-9aszklx3 68 8 of of IN cord-335432-9aszklx3 68 9 the the DT cord-335432-9aszklx3 68 10 14 14 CD cord-335432-9aszklx3 68 11 pathogens pathogen NNS cord-335432-9aszklx3 68 12 and and CC cord-335432-9aszklx3 68 13 produces produce VBZ cord-335432-9aszklx3 68 14 , , , cord-335432-9aszklx3 68 15 aims aim VBZ cord-335432-9aszklx3 68 16 to to TO cord-335432-9aszklx3 68 17 produce produce VB cord-335432-9aszklx3 68 18 , , , cord-335432-9aszklx3 68 19 or or CC cord-335432-9aszklx3 68 20 can can MD cord-335432-9aszklx3 68 21 be be VB cord-335432-9aszklx3 68 22 reasonably reasonably RB cord-335432-9aszklx3 68 23 anticipated anticipate VBN cord-335432-9aszklx3 68 24 to to TO cord-335432-9aszklx3 68 25 alter alter VB cord-335432-9aszklx3 68 26 ( ( -LRB- cord-335432-9aszklx3 68 27 a a DT cord-335432-9aszklx3 68 28 ) ) -RRB- cord-335432-9aszklx3 68 29 transmission transmission NN cord-335432-9aszklx3 68 30 ( ( -LRB- cord-335432-9aszklx3 68 31 T T NNP cord-335432-9aszklx3 68 32 ) ) -RRB- cord-335432-9aszklx3 68 33 , , , cord-335432-9aszklx3 68 34 range range NN cord-335432-9aszklx3 68 35 and and CC cord-335432-9aszklx3 68 36 resistance resistance NN cord-335432-9aszklx3 68 37 ( ( -LRB- cord-335432-9aszklx3 68 38 R r NN cord-335432-9aszklx3 68 39 ) ) -RRB- cord-335432-9aszklx3 68 40 , , , cord-335432-9aszklx3 68 41 infectivity/ infectivity/ CD cord-335432-9aszklx3 68 42 immunity immunity NN cord-335432-9aszklx3 68 43 ( ( -LRB- cord-335432-9aszklx3 68 44 I i NN cord-335432-9aszklx3 68 45 ) ) -RRB- cord-335432-9aszklx3 68 46 , , , cord-335432-9aszklx3 68 47 and and CC cord-335432-9aszklx3 68 48 pathogenesis pathogenesis NN cord-335432-9aszklx3 68 49 ( ( -LRB- cord-335432-9aszklx3 68 50 P p NN cord-335432-9aszklx3 68 51 ) ) -RRB- cord-335432-9aszklx3 69 1 is be VBZ cord-335432-9aszklx3 69 2 what what WP cord-335432-9aszklx3 69 3 concerns concern VBZ cord-335432-9aszklx3 69 4 us -PRON- PRP cord-335432-9aszklx3 69 5 ; ; : cord-335432-9aszklx3 69 6 this this DT cord-335432-9aszklx3 69 7 can can MD cord-335432-9aszklx3 69 8 be be VB cord-335432-9aszklx3 69 9 condensed condense VBN cord-335432-9aszklx3 69 10 to to IN cord-335432-9aszklx3 69 11 " " `` cord-335432-9aszklx3 69 12 aTRIP atrip JJ cord-335432-9aszklx3 69 13 . . . cord-335432-9aszklx3 70 1 " " '' cord-335432-9aszklx3 71 1 This this DT cord-335432-9aszklx3 71 2 simple simple JJ cord-335432-9aszklx3 71 3 acronym acronym NN cord-335432-9aszklx3 71 4 precisely precisely RB cord-335432-9aszklx3 71 5 identifies identify VBZ cord-335432-9aszklx3 71 6 the the DT cord-335432-9aszklx3 71 7 functions function NNS cord-335432-9aszklx3 71 8 of of IN cord-335432-9aszklx3 71 9 concern concern NN cord-335432-9aszklx3 71 10 , , , cord-335432-9aszklx3 71 11 moves move VBZ cord-335432-9aszklx3 71 12 away away RB cord-335432-9aszklx3 71 13 from from IN cord-335432-9aszklx3 71 14 the the DT cord-335432-9aszklx3 71 15 current current JJ cord-335432-9aszklx3 71 16 preoccupation preoccupation NN cord-335432-9aszklx3 71 17 with with IN cord-335432-9aszklx3 71 18 enhancement enhancement NN cord-335432-9aszklx3 71 19 , , , cord-335432-9aszklx3 71 20 and and CC cord-335432-9aszklx3 71 21 does do VBZ cord-335432-9aszklx3 71 22 not not RB cord-335432-9aszklx3 71 23 assume assume VB cord-335432-9aszklx3 71 24 that that IN cord-335432-9aszklx3 71 25 dual dual JJ cord-335432-9aszklx3 71 26 use use NN cord-335432-9aszklx3 71 27 is be VBZ cord-335432-9aszklx3 71 28 pertinent pertinent JJ cord-335432-9aszklx3 71 29 from from IN cord-335432-9aszklx3 71 30 the the DT cord-335432-9aszklx3 71 31 outset outset NN cord-335432-9aszklx3 71 32 . . . cord-335432-9aszklx3 72 1 Although although IN cord-335432-9aszklx3 72 2 potentially potentially RB cord-335432-9aszklx3 72 3 applicable applicable JJ cord-335432-9aszklx3 72 4 to to IN cord-335432-9aszklx3 72 5 all all DT cord-335432-9aszklx3 72 6 of of IN cord-335432-9aszklx3 72 7 microbiology microbiology NN cord-335432-9aszklx3 72 8 , , , cord-335432-9aszklx3 72 9 it -PRON- PRP cord-335432-9aszklx3 72 10 should should MD cord-335432-9aszklx3 72 11 be be VB cord-335432-9aszklx3 72 12 used use VBN cord-335432-9aszklx3 72 13 to to TO cord-335432-9aszklx3 72 14 identify identify VB cord-335432-9aszklx3 72 15 only only RB cord-335432-9aszklx3 72 16 the the DT cord-335432-9aszklx3 72 17 small small JJ cord-335432-9aszklx3 72 18 subset subset NN cord-335432-9aszklx3 72 19 of of IN cord-335432-9aszklx3 72 20 experiments experiment NNS cord-335432-9aszklx3 72 21 with with IN cord-335432-9aszklx3 72 22 prescribed prescribed JJ cord-335432-9aszklx3 72 23 pathogens pathogen NNS cord-335432-9aszklx3 72 24 which which WDT cord-335432-9aszklx3 72 25 may may MD cord-335432-9aszklx3 72 26 produce produce VB cord-335432-9aszklx3 72 27 data datum NNS cord-335432-9aszklx3 72 28 relevant relevant JJ cord-335432-9aszklx3 72 29 for for IN cord-335432-9aszklx3 72 30 biosecurity biosecurity NN cord-335432-9aszklx3 73 1 ( ( -LRB- cord-335432-9aszklx3 73 2 Fig Fig NNP cord-335432-9aszklx3 73 3 . . . cord-335432-9aszklx3 73 4 1D 1d CD cord-335432-9aszklx3 73 5 , , , cord-335432-9aszklx3 73 6 red red JJ cord-335432-9aszklx3 73 7 circle circle NN cord-335432-9aszklx3 73 8 ) ) -RRB- cord-335432-9aszklx3 73 9 . . . cord-335432-9aszklx3 74 1 Focusing focus VBG cord-335432-9aszklx3 74 2 on on IN cord-335432-9aszklx3 74 3 alterations alteration NNS cord-335432-9aszklx3 74 4 to to IN cord-335432-9aszklx3 74 5 explicit explicit JJ cord-335432-9aszklx3 74 6 phenotypes phenotype NNS cord-335432-9aszklx3 74 7 will will MD cord-335432-9aszklx3 74 8 help help VB cord-335432-9aszklx3 74 9 scientists scientist NNS cord-335432-9aszklx3 74 10 think think VB cord-335432-9aszklx3 74 11 holis holis NNP cord-335432-9aszklx3 74 12 - - : cord-335432-9aszklx3 74 13 tically tically RB cord-335432-9aszklx3 74 14 during during IN cord-335432-9aszklx3 74 15 experimental experimental JJ cord-335432-9aszklx3 74 16 design design NN cord-335432-9aszklx3 74 17 and and CC cord-335432-9aszklx3 74 18 assist assist VB cord-335432-9aszklx3 74 19 members member NNS cord-335432-9aszklx3 74 20 of of IN cord-335432-9aszklx3 74 21 the the DT cord-335432-9aszklx3 74 22 IBC/ ibc/ CD cord-335432-9aszklx3 74 23 IRE IRE NNP cord-335432-9aszklx3 74 24 during during IN cord-335432-9aszklx3 74 25 application application NN cord-335432-9aszklx3 74 26 evaluation evaluation NN cord-335432-9aszklx3 74 27 . . . cord-335432-9aszklx3 75 1 We -PRON- PRP cord-335432-9aszklx3 75 2 consider consider VBP cord-335432-9aszklx3 75 3 this this DT cord-335432-9aszklx3 75 4 a a DT cord-335432-9aszklx3 75 5 simple simple JJ cord-335432-9aszklx3 75 6 and and CC cord-335432-9aszklx3 75 7 pragmatic pragmatic JJ cord-335432-9aszklx3 75 8 resolution resolution NN cord-335432-9aszklx3 75 9 to to IN cord-335432-9aszklx3 75 10 the the DT cord-335432-9aszklx3 75 11 lexiconic lexiconic NNP cord-335432-9aszklx3 75 12 muddle muddle NN cord-335432-9aszklx3 75 13 which which WDT cord-335432-9aszklx3 75 14 , , , cord-335432-9aszklx3 75 15 if if IN cord-335432-9aszklx3 75 16 adopted adopt VBN cord-335432-9aszklx3 75 17 to to TO cord-335432-9aszklx3 75 18 describe describe VB cord-335432-9aszklx3 75 19 experiments experiment NNS cord-335432-9aszklx3 75 20 of of IN cord-335432-9aszklx3 75 21 concern concern NN cord-335432-9aszklx3 75 22 for for IN cord-335432-9aszklx3 75 23 any any DT cord-335432-9aszklx3 75 24 pathogen pathogen NN cord-335432-9aszklx3 75 25 requiring require VBG cord-335432-9aszklx3 75 26 DURC DURC NNP cord-335432-9aszklx3 75 27 oversight oversight NN cord-335432-9aszklx3 75 28 , , , cord-335432-9aszklx3 75 29 would would MD cord-335432-9aszklx3 75 30 be be VB cord-335432-9aszklx3 75 31 workable workable JJ cord-335432-9aszklx3 75 32 across across IN cord-335432-9aszklx3 75 33 all all DT cord-335432-9aszklx3 75 34 of of IN cord-335432-9aszklx3 75 35 microbiology microbiology NN cord-335432-9aszklx3 75 36 . . . cord-335432-9aszklx3 76 1 From from IN cord-335432-9aszklx3 76 2 the the DT cord-335432-9aszklx3 76 3 outset outset NN cord-335432-9aszklx3 76 4 of of IN cord-335432-9aszklx3 76 5 this this DT cord-335432-9aszklx3 76 6 debate debate NN cord-335432-9aszklx3 76 7 , , , cord-335432-9aszklx3 76 8 microbiologists microbiologist NNS cord-335432-9aszklx3 76 9 were be VBD cord-335432-9aszklx3 76 10 concerned concern VBN cord-335432-9aszklx3 76 11 that that IN cord-335432-9aszklx3 76 12 " " `` cord-335432-9aszklx3 76 13 creep creep NN cord-335432-9aszklx3 76 14 " " '' cord-335432-9aszklx3 76 15 would would MD cord-335432-9aszklx3 76 16 occur occur VB cord-335432-9aszklx3 76 17 and and CC cord-335432-9aszklx3 76 18 that that IN cord-335432-9aszklx3 76 19 the the DT cord-335432-9aszklx3 76 20 list list NN cord-335432-9aszklx3 76 21 of of IN cord-335432-9aszklx3 76 22 DURC DURC NNP cord-335432-9aszklx3 76 23 - - HYPH cord-335432-9aszklx3 76 24 relevant relevant JJ cord-335432-9aszklx3 76 25 agents agent NNS cord-335432-9aszklx3 76 26 would would MD cord-335432-9aszklx3 76 27 inevitably inevitably RB cord-335432-9aszklx3 76 28 expand expand VB cord-335432-9aszklx3 76 29 . . . cord-335432-9aszklx3 77 1 Many many JJ cord-335432-9aszklx3 77 2 in in IN cord-335432-9aszklx3 77 3 the the DT cord-335432-9aszklx3 77 4 community community NN cord-335432-9aszklx3 77 5 predicted predict VBD cord-335432-9aszklx3 77 6 a a DT cord-335432-9aszklx3 77 7 " " `` cord-335432-9aszklx3 77 8 slippery slippery JJ cord-335432-9aszklx3 77 9 slope slope NN cord-335432-9aszklx3 77 10 " " '' cord-335432-9aszklx3 77 11 and and CC cord-335432-9aszklx3 77 12 waited wait VBD cord-335432-9aszklx3 77 13 for for IN cord-335432-9aszklx3 77 14 additional additional JJ cord-335432-9aszklx3 77 15 oversight oversight NN cord-335432-9aszklx3 77 16 . . . cord-335432-9aszklx3 78 1 The the DT cord-335432-9aszklx3 78 2 current current JJ cord-335432-9aszklx3 78 3 " " `` cord-335432-9aszklx3 78 4 pause pause NN cord-335432-9aszklx3 78 5 , , , cord-335432-9aszklx3 78 6 " " '' cord-335432-9aszklx3 78 7 which which WDT cord-335432-9aszklx3 78 8 added add VBD cord-335432-9aszklx3 78 9 studies study NNS cord-335432-9aszklx3 78 10 on on IN cord-335432-9aszklx3 78 11 MERS MERS NNP cord-335432-9aszklx3 78 12 and and CC cord-335432-9aszklx3 78 13 SARS SARS NNP cord-335432-9aszklx3 78 14 coronaviruses coronaviruse NNS cord-335432-9aszklx3 78 15 and and CC cord-335432-9aszklx3 78 16 low low JJ cord-335432-9aszklx3 78 17 pathogenicity pathogenicity NN cord-335432-9aszklx3 78 18 avian avian JJ cord-335432-9aszklx3 78 19 influenza influenza NN cord-335432-9aszklx3 78 20 viruses virus NNS cord-335432-9aszklx3 78 21 to to IN cord-335432-9aszklx3 78 22 the the DT cord-335432-9aszklx3 78 23 list list NN cord-335432-9aszklx3 78 24 , , , cord-335432-9aszklx3 78 25 proves prove VBZ cord-335432-9aszklx3 78 26 that that IN cord-335432-9aszklx3 78 27 their -PRON- PRP$ cord-335432-9aszklx3 78 28 concerns concern NNS cord-335432-9aszklx3 78 29 were be VBD cord-335432-9aszklx3 78 30 legitimate legitimate JJ cord-335432-9aszklx3 78 31 . . . cord-335432-9aszklx3 79 1 Many many JJ cord-335432-9aszklx3 79 2 believe believe VBP cord-335432-9aszklx3 79 3 that that IN cord-335432-9aszklx3 79 4 calls call VBZ cord-335432-9aszklx3 79 5 for for IN cord-335432-9aszklx3 79 6 increased increase VBN cord-335432-9aszklx3 79 7 regulation regulation NN cord-335432-9aszklx3 79 8 and and CC cord-335432-9aszklx3 79 9 risk risk NN cord-335432-9aszklx3 79 10 - - HYPH cord-335432-9aszklx3 79 11 benefit benefit NN cord-335432-9aszklx3 79 12 analyses analysis NNS cord-335432-9aszklx3 79 13 are be VBP cord-335432-9aszklx3 79 14 knee knee NN cord-335432-9aszklx3 79 15 - - HYPH cord-335432-9aszklx3 79 16 jerk jerk NN cord-335432-9aszklx3 79 17 reactions reaction NNS cord-335432-9aszklx3 79 18 which which WDT cord-335432-9aszklx3 79 19 are be VBP cord-335432-9aszklx3 79 20 not not RB cord-335432-9aszklx3 79 21 based base VBN cord-335432-9aszklx3 79 22 on on IN cord-335432-9aszklx3 79 23 scientific scientific JJ cord-335432-9aszklx3 79 24 evidence evidence NN cord-335432-9aszklx3 79 25 ( ( -LRB- cord-335432-9aszklx3 79 26 7 7 CD cord-335432-9aszklx3 79 27 ) ) -RRB- cord-335432-9aszklx3 79 28 . . . cord-335432-9aszklx3 80 1 They -PRON- PRP cord-335432-9aszklx3 80 2 argue argue VBP cord-335432-9aszklx3 80 3 that that IN cord-335432-9aszklx3 80 4 opponents opponent NNS cord-335432-9aszklx3 80 5 of of IN cord-335432-9aszklx3 80 6 the the DT cord-335432-9aszklx3 80 7 research research NN cord-335432-9aszklx3 80 8 do do VBP cord-335432-9aszklx3 80 9 not not RB cord-335432-9aszklx3 80 10 recognize recognize VB cord-335432-9aszklx3 80 11 the the DT cord-335432-9aszklx3 80 12 functionality functionality NN cord-335432-9aszklx3 80 13 of of IN cord-335432-9aszklx3 80 14 existing exist VBG cord-335432-9aszklx3 80 15 biocontainment biocontainment NN cord-335432-9aszklx3 80 16 practices practice NNS cord-335432-9aszklx3 80 17 or or CC cord-335432-9aszklx3 80 18 appreciate appreciate VBP cord-335432-9aszklx3 80 19 the the DT cord-335432-9aszklx3 80 20 extensive extensive JJ cord-335432-9aszklx3 80 21 risk risk NN cord-335432-9aszklx3 80 22 mitigation mitigation NN cord-335432-9aszklx3 80 23 practices practice NNS cord-335432-9aszklx3 80 24 currently currently RB cord-335432-9aszklx3 80 25 in in IN cord-335432-9aszklx3 80 26 place place NN cord-335432-9aszklx3 80 27 to to TO cord-335432-9aszklx3 80 28 permit permit VB cord-335432-9aszklx3 80 29 microbiologists microbiologist NNS cord-335432-9aszklx3 80 30 to to TO cord-335432-9aszklx3 80 31 work work VB cord-335432-9aszklx3 80 32 with with IN cord-335432-9aszklx3 80 33 dangerous dangerous JJ cord-335432-9aszklx3 80 34 pathogens pathogen NNS cord-335432-9aszklx3 80 35 safely safely RB cord-335432-9aszklx3 80 36 . . . cord-335432-9aszklx3 81 1 The the DT cord-335432-9aszklx3 81 2 subtle subtle JJ cord-335432-9aszklx3 81 3 shift shift NN cord-335432-9aszklx3 81 4 in in IN cord-335432-9aszklx3 81 5 focus focus NN cord-335432-9aszklx3 81 6 from from IN cord-335432-9aszklx3 81 7 biosecurity biosecurity NN cord-335432-9aszklx3 81 8 to to IN cord-335432-9aszklx3 81 9 biosafety biosafety NN cord-335432-9aszklx3 81 10 issues issue NNS cord-335432-9aszklx3 81 11 also also RB cord-335432-9aszklx3 81 12 leads lead VBZ cord-335432-9aszklx3 81 13 to to IN cord-335432-9aszklx3 81 14 confusion confusion NN cord-335432-9aszklx3 81 15 and and CC cord-335432-9aszklx3 81 16 once once RB cord-335432-9aszklx3 81 17 again again RB cord-335432-9aszklx3 81 18 illustrates illustrate VBZ cord-335432-9aszklx3 81 19 why why WRB cord-335432-9aszklx3 81 20 using use VBG cord-335432-9aszklx3 81 21 precise precise JJ cord-335432-9aszklx3 81 22 terminology terminology NN cord-335432-9aszklx3 81 23 is be VBZ cord-335432-9aszklx3 81 24 critical critical JJ cord-335432-9aszklx3 81 25 . . . cord-335432-9aszklx3 82 1 Microbiologists microbiologist NNS cord-335432-9aszklx3 82 2 should should MD cord-335432-9aszklx3 82 3 not not RB cord-335432-9aszklx3 82 4 be be VB cord-335432-9aszklx3 82 5 complacent complacent JJ cord-335432-9aszklx3 82 6 and and CC cord-335432-9aszklx3 82 7 must must MD cord-335432-9aszklx3 82 8 be be VB cord-335432-9aszklx3 82 9 open open JJ cord-335432-9aszklx3 82 10 to to IN cord-335432-9aszklx3 82 11 suggestions suggestion NNS cord-335432-9aszklx3 82 12 and and CC cord-335432-9aszklx3 82 13 approaches approach NNS cord-335432-9aszklx3 82 14 from from IN cord-335432-9aszklx3 82 15 other other JJ cord-335432-9aszklx3 82 16 fields field NNS cord-335432-9aszklx3 82 17 . . . cord-335432-9aszklx3 83 1 Meaningful meaningful JJ cord-335432-9aszklx3 83 2 , , , cord-335432-9aszklx3 83 3 quantifiable quantifiable JJ cord-335432-9aszklx3 83 4 , , , cord-335432-9aszklx3 83 5 evidence evidence NN cord-335432-9aszklx3 83 6 - - HYPH cord-335432-9aszklx3 83 7 based base VBN cord-335432-9aszklx3 83 8 assessments assessment NNS cord-335432-9aszklx3 83 9 are be VBP cord-335432-9aszklx3 83 10 not not RB cord-335432-9aszklx3 83 11 a a DT cord-335432-9aszklx3 83 12 threat threat NN cord-335432-9aszklx3 83 13 to to IN cord-335432-9aszklx3 83 14 research research NN cord-335432-9aszklx3 83 15 . . . cord-335432-9aszklx3 84 1 There there EX cord-335432-9aszklx3 84 2 is be VBZ cord-335432-9aszklx3 84 3 a a DT cord-335432-9aszklx3 84 4 responsibility responsibility NN cord-335432-9aszklx3 84 5 to to TO cord-335432-9aszklx3 84 6 communicate communicate VB cord-335432-9aszklx3 84 7 clearly clearly RB cord-335432-9aszklx3 84 8 when when WRB cord-335432-9aszklx3 84 9 undertaking undertake VBG cord-335432-9aszklx3 84 10 an an DT cord-335432-9aszklx3 84 11 aTRIP atrip JJ cord-335432-9aszklx3 84 12 experiment experiment NN cord-335432-9aszklx3 84 13 and and CC cord-335432-9aszklx3 84 14 justifying justify VBG cord-335432-9aszklx3 84 15 to to IN cord-335432-9aszklx3 84 16 an an DT cord-335432-9aszklx3 84 17 IBC/ ibc/ JJ cord-335432-9aszklx3 84 18 IRE ire NN cord-335432-9aszklx3 84 19 why why WRB cord-335432-9aszklx3 84 20 altering alter VBG cord-335432-9aszklx3 84 21 transmissibility transmissibility NN cord-335432-9aszklx3 84 22 or or CC cord-335432-9aszklx3 84 23 range range NN cord-335432-9aszklx3 84 24 or or CC cord-335432-9aszklx3 84 25 making make VBG cord-335432-9aszklx3 84 26 a a DT cord-335432-9aszklx3 84 27 resistant resistant JJ cord-335432-9aszklx3 84 28 mutant mutant NN cord-335432-9aszklx3 84 29 is be VBZ cord-335432-9aszklx3 84 30 necessary necessary JJ cord-335432-9aszklx3 84 31 . . . cord-335432-9aszklx3 85 1 To to TO cord-335432-9aszklx3 85 2 conclude conclude VB cord-335432-9aszklx3 85 3 , , , cord-335432-9aszklx3 85 4 let let VB cord-335432-9aszklx3 85 5 us -PRON- PRP cord-335432-9aszklx3 85 6 return return VB cord-335432-9aszklx3 85 7 full full JJ cord-335432-9aszklx3 85 8 circle circle NN cord-335432-9aszklx3 85 9 , , , cord-335432-9aszklx3 85 10 something something NN cord-335432-9aszklx3 85 11 which which WDT cord-335432-9aszklx3 85 12 is be VBZ cord-335432-9aszklx3 85 13 useful useful JJ cord-335432-9aszklx3 85 14 when when WRB cord-335432-9aszklx3 85 15 we -PRON- PRP cord-335432-9aszklx3 85 16 are be VBP cord-335432-9aszklx3 85 17 puzzled puzzled JJ cord-335432-9aszklx3 85 18 . . . cord-335432-9aszklx3 86 1 When when WRB cord-335432-9aszklx3 86 2 Humpty Humpty NNP cord-335432-9aszklx3 86 3 met meet VBD cord-335432-9aszklx3 86 4 Alice Alice NNP cord-335432-9aszklx3 86 5 , , , cord-335432-9aszklx3 86 6 he -PRON- PRP cord-335432-9aszklx3 86 7 asked ask VBD cord-335432-9aszklx3 86 8 the the DT cord-335432-9aszklx3 86 9 intrepid intrepid JJ cord-335432-9aszklx3 86 10 adventurer adventurer NN cord-335432-9aszklx3 86 11 " " `` cord-335432-9aszklx3 86 12 tell tell VBP cord-335432-9aszklx3 86 13 me -PRON- PRP cord-335432-9aszklx3 86 14 your -PRON- PRP$ cord-335432-9aszklx3 86 15 name name NN cord-335432-9aszklx3 86 16 and and CC cord-335432-9aszklx3 86 17 your -PRON- PRP$ cord-335432-9aszklx3 86 18 business business NN cord-335432-9aszklx3 86 19 ? ? . cord-335432-9aszklx3 86 20 " " '' cord-335432-9aszklx3 87 1 On on IN cord-335432-9aszklx3 87 2 face face NN cord-335432-9aszklx3 87 3 value value NN cord-335432-9aszklx3 87 4 , , , cord-335432-9aszklx3 87 5 this this DT cord-335432-9aszklx3 87 6 is be VBZ cord-335432-9aszklx3 87 7 a a DT cord-335432-9aszklx3 87 8 much much RB cord-335432-9aszklx3 87 9 more more RBR cord-335432-9aszklx3 87 10 reasonable reasonable JJ cord-335432-9aszklx3 87 11 approach approach NN cord-335432-9aszklx3 87 12 to to TO cord-335432-9aszklx3 87 13 dialog dialog VB cord-335432-9aszklx3 87 14 from from IN cord-335432-9aszklx3 87 15 the the DT cord-335432-9aszklx3 87 16 cantankerous cantankerous JJ cord-335432-9aszklx3 87 17 egg egg NN cord-335432-9aszklx3 87 18 , , , cord-335432-9aszklx3 87 19 but but CC cord-335432-9aszklx3 87 20 as as IN cord-335432-9aszklx3 87 21 usual usual JJ cord-335432-9aszklx3 87 22 , , , cord-335432-9aszklx3 87 23 in in IN cord-335432-9aszklx3 87 24 Wonderland Wonderland NNP cord-335432-9aszklx3 87 25 , , , cord-335432-9aszklx3 87 26 things thing NNS cord-335432-9aszklx3 87 27 are be VBP cord-335432-9aszklx3 87 28 never never RB cord-335432-9aszklx3 87 29 as as IN cord-335432-9aszklx3 87 30 they -PRON- PRP cord-335432-9aszklx3 87 31 seem seem VBP cord-335432-9aszklx3 87 32 . . . cord-335432-9aszklx3 87 33 ' ' '' cord-335432-9aszklx3 88 1 " " `` cord-335432-9aszklx3 88 2 My -PRON- PRP$ cord-335432-9aszklx3 88 3 name name NN cord-335432-9aszklx3 88 4 is be VBZ cord-335432-9aszklx3 88 5 Alice Alice NNP cord-335432-9aszklx3 88 6 , , , cord-335432-9aszklx3 88 7 but- but- JJ cord-335432-9aszklx3 88 8 " " '' cord-335432-9aszklx3 88 9 . . . cord-335432-9aszklx3 88 10 . . . cord-335432-9aszklx3 88 11 . . . cord-335432-9aszklx3 89 1 " " `` cord-335432-9aszklx3 89 2 It -PRON- PRP cord-335432-9aszklx3 89 3 's be VBZ cord-335432-9aszklx3 89 4 a a DT cord-335432-9aszklx3 89 5 stupid stupid JJ cord-335432-9aszklx3 89 6 name name NN cord-335432-9aszklx3 89 7 enough enough RB cord-335432-9aszklx3 89 8 ! ! . cord-335432-9aszklx3 89 9 " " '' cord-335432-9aszklx3 90 1 Humpty Humpty NNP cord-335432-9aszklx3 90 2 Dumpty Dumpty NNP cord-335432-9aszklx3 90 3 interrupted interrupt VBD cord-335432-9aszklx3 90 4 impatiently impatiently RB cord-335432-9aszklx3 90 5 . . . cord-335432-9aszklx3 91 1 " " '' cord-335432-9aszklx3 92 1 What what WP cord-335432-9aszklx3 92 2 does do VBZ cord-335432-9aszklx3 92 3 it -PRON- PRP cord-335432-9aszklx3 92 4 mean mean VB cord-335432-9aszklx3 92 5 ? ? . cord-335432-9aszklx3 92 6 " " '' cord-335432-9aszklx3 93 1 " " `` cord-335432-9aszklx3 93 2 Must Must MD cord-335432-9aszklx3 93 3 a a DT cord-335432-9aszklx3 93 4 name name NN cord-335432-9aszklx3 93 5 mean mean VB cord-335432-9aszklx3 93 6 something something NN cord-335432-9aszklx3 93 7 ? ? . cord-335432-9aszklx3 93 8 " " '' cord-335432-9aszklx3 94 1 Alice Alice NNP cord-335432-9aszklx3 94 2 asked ask VBD cord-335432-9aszklx3 94 3 doubtfully doubtfully RB cord-335432-9aszklx3 94 4 . . . cord-335432-9aszklx3 95 1 " " '' cord-335432-9aszklx3 96 1 Of of RB cord-335432-9aszklx3 96 2 course course RB cord-335432-9aszklx3 96 3 it -PRON- PRP cord-335432-9aszklx3 96 4 must must MD cord-335432-9aszklx3 96 5 , , , cord-335432-9aszklx3 96 6 " " `` cord-335432-9aszklx3 96 7 Humpty Humpty NNP cord-335432-9aszklx3 96 8 Dumpty Dumpty NNP cord-335432-9aszklx3 96 9 said say VBD cord-335432-9aszklx3 96 10 with with IN cord-335432-9aszklx3 96 11 a a DT cord-335432-9aszklx3 96 12 short short JJ cord-335432-9aszklx3 96 13 laugh laugh NN cord-335432-9aszklx3 96 14 ! ! . cord-335432-9aszklx3 96 15 ' ' '' cord-335432-9aszklx3 97 1 ( ( -LRB- cord-335432-9aszklx3 97 2 1 1 CD cord-335432-9aszklx3 97 3 ) ) -RRB- cord-335432-9aszklx3 97 4 . . . cord-335432-9aszklx3 98 1 Does do VBZ cord-335432-9aszklx3 98 2 the the DT cord-335432-9aszklx3 98 3 name name NN cord-335432-9aszklx3 98 4 aTRIP atrip JJ cord-335432-9aszklx3 98 5 help help NN cord-335432-9aszklx3 98 6 , , , cord-335432-9aszklx3 98 7 or or CC cord-335432-9aszklx3 98 8 does do VBZ cord-335432-9aszklx3 98 9 it -PRON- PRP cord-335432-9aszklx3 98 10 just just RB cord-335432-9aszklx3 98 11 add add VB cord-335432-9aszklx3 98 12 more more JJR cord-335432-9aszklx3 98 13 complexity complexity NN cord-335432-9aszklx3 98 14 to to IN cord-335432-9aszklx3 98 15 this this DT cord-335432-9aszklx3 98 16 muddle muddle NN cord-335432-9aszklx3 98 17 ? ? . cord-335432-9aszklx3 99 1 It -PRON- PRP cord-335432-9aszklx3 99 2 would would MD cord-335432-9aszklx3 99 3 satisfy satisfy VB cord-335432-9aszklx3 99 4 colleagues colleague NNS cord-335432-9aszklx3 99 5 who who WP cord-335432-9aszklx3 99 6 demand demand VBP cord-335432-9aszklx3 99 7 precision precision NN cord-335432-9aszklx3 99 8 and and CC cord-335432-9aszklx3 99 9 agree agree VBP cord-335432-9aszklx3 99 10 that that IN cord-335432-9aszklx3 99 11 names name NNS cord-335432-9aszklx3 99 12 should should MD cord-335432-9aszklx3 99 13 mean mean VB cord-335432-9aszklx3 99 14 something something NN cord-335432-9aszklx3 99 15 . . . cord-335432-9aszklx3 100 1 It -PRON- PRP cord-335432-9aszklx3 100 2 specifies specify VBZ cord-335432-9aszklx3 100 3 the the DT cord-335432-9aszklx3 100 4 altered altered JJ cord-335432-9aszklx3 100 5 functions function NNS cord-335432-9aszklx3 100 6 that that WDT cord-335432-9aszklx3 100 7 cause cause VBP cord-335432-9aszklx3 100 8 concern concern NN cord-335432-9aszklx3 100 9 , , , cord-335432-9aszklx3 100 10 does do VBZ cord-335432-9aszklx3 100 11 not not RB cord-335432-9aszklx3 100 12 assume assume VB cord-335432-9aszklx3 100 13 dual dual JJ cord-335432-9aszklx3 100 14 - - HYPH cord-335432-9aszklx3 100 15 use use NN cord-335432-9aszklx3 100 16 potential potential NN cord-335432-9aszklx3 100 17 from from IN cord-335432-9aszklx3 100 18 the the DT cord-335432-9aszklx3 100 19 outset outset NN cord-335432-9aszklx3 100 20 , , , cord-335432-9aszklx3 100 21 but but CC cord-335432-9aszklx3 100 22 still still RB cord-335432-9aszklx3 100 23 prompts prompt VBZ cord-335432-9aszklx3 100 24 investigators investigator NNS cord-335432-9aszklx3 100 25 and and CC cord-335432-9aszklx3 100 26 overseers overseer NNS cord-335432-9aszklx3 100 27 to to TO cord-335432-9aszklx3 100 28 consider consider VB cord-335432-9aszklx3 100 29 the the DT cord-335432-9aszklx3 100 30 possibility possibility NN cord-335432-9aszklx3 100 31 . . . cord-335432-9aszklx3 101 1 It -PRON- PRP cord-335432-9aszklx3 101 2 would would MD cord-335432-9aszklx3 101 3 act act VB cord-335432-9aszklx3 101 4 as as IN cord-335432-9aszklx3 101 5 a a DT cord-335432-9aszklx3 101 6 filter filter NN cord-335432-9aszklx3 101 7 . . . cord-335432-9aszklx3 102 1 Microbial microbial JJ cord-335432-9aszklx3 102 2 genetics genetics NN cord-335432-9aszklx3 102 3 experiments experiment NNS cord-335432-9aszklx3 102 4 often often RB cord-335432-9aszklx3 102 5 involve involve VBP cord-335432-9aszklx3 102 6 selection selection NN cord-335432-9aszklx3 102 7 processes process NNS cord-335432-9aszklx3 102 8 ; ; : cord-335432-9aszklx3 102 9 not not RB cord-335432-9aszklx3 102 10 all all DT cord-335432-9aszklx3 102 11 alter alter VB cord-335432-9aszklx3 102 12 specific specific JJ cord-335432-9aszklx3 102 13 phenotypes phenotype NNS cord-335432-9aszklx3 102 14 , , , cord-335432-9aszklx3 102 15 far far RB cord-335432-9aszklx3 102 16 fewer few JJR cord-335432-9aszklx3 102 17 use use NN cord-335432-9aszklx3 102 18 pathogens pathogen NNS cord-335432-9aszklx3 102 19 on on IN cord-335432-9aszklx3 102 20 the the DT cord-335432-9aszklx3 102 21 current current JJ cord-335432-9aszklx3 102 22 list list NN cord-335432-9aszklx3 102 23 , , , cord-335432-9aszklx3 102 24 and and CC cord-335432-9aszklx3 102 25 even even RB cord-335432-9aszklx3 102 26 fewer few JJR cord-335432-9aszklx3 102 27 involve involve VBP cord-335432-9aszklx3 102 28 creation creation NN cord-335432-9aszklx3 102 29 of of IN cord-335432-9aszklx3 102 30 agents agent NNS cord-335432-9aszklx3 102 31 which which WDT cord-335432-9aszklx3 102 32 are be VBP cord-335432-9aszklx3 102 33 novel novel JJ cord-335432-9aszklx3 102 34 in in IN cord-335432-9aszklx3 102 35 any any DT cord-335432-9aszklx3 102 36 meaningful meaningful JJ cord-335432-9aszklx3 102 37 sense sense NN cord-335432-9aszklx3 102 38 of of IN cord-335432-9aszklx3 102 39 the the DT cord-335432-9aszklx3 102 40 word word NN cord-335432-9aszklx3 102 41 . . . cord-335432-9aszklx3 103 1 This this DT cord-335432-9aszklx3 103 2 is be VBZ cord-335432-9aszklx3 103 3 a a DT cord-335432-9aszklx3 103 4 scientific scientific JJ cord-335432-9aszklx3 103 5 and and CC cord-335432-9aszklx3 103 6 rational rational JJ cord-335432-9aszklx3 103 7 approach approach NN cord-335432-9aszklx3 103 8 to to IN cord-335432-9aszklx3 103 9 nomenclature nomenclature NN cord-335432-9aszklx3 103 10 which which WDT cord-335432-9aszklx3 103 11 cuts cut VBZ cord-335432-9aszklx3 103 12 through through IN cord-335432-9aszklx3 103 13 the the DT cord-335432-9aszklx3 103 14 " " `` cord-335432-9aszklx3 103 15 GOF"-smog GOF"-smog NNP cord-335432-9aszklx3 103 16 . . . cord-335432-9aszklx3 104 1 It -PRON- PRP cord-335432-9aszklx3 104 2 stands stand VBZ cord-335432-9aszklx3 104 3 as as IN cord-335432-9aszklx3 104 4 a a DT cord-335432-9aszklx3 104 5 straw straw NN cord-335432-9aszklx3 104 6 man man NN cord-335432-9aszklx3 104 7 ready ready JJ cord-335432-9aszklx3 104 8 to to TO cord-335432-9aszklx3 104 9 be be VB cord-335432-9aszklx3 104 10 knocked knock VBN cord-335432-9aszklx3 104 11 down down RP cord-335432-9aszklx3 104 12 . . . cord-335432-9aszklx3 105 1 It -PRON- PRP cord-335432-9aszklx3 105 2 is be VBZ cord-335432-9aszklx3 105 3 meant mean VBN cord-335432-9aszklx3 105 4 to to TO cord-335432-9aszklx3 105 5 provoke provoke VB cord-335432-9aszklx3 105 6 debate debate NN cord-335432-9aszklx3 105 7 and and CC cord-335432-9aszklx3 105 8 help help VB cord-335432-9aszklx3 105 9 microbiology microbiology NN cord-335432-9aszklx3 105 10 set set VBN cord-335432-9aszklx3 105 11 the the DT cord-335432-9aszklx3 105 12 terms term NNS cord-335432-9aszklx3 105 13 rather rather RB cord-335432-9aszklx3 105 14 than than IN cord-335432-9aszklx3 105 15 be be VB cord-335432-9aszklx3 105 16 subject subject JJ cord-335432-9aszklx3 105 17 to to IN cord-335432-9aszklx3 105 18 terms term NNS cord-335432-9aszklx3 105 19 . . . cord-335432-9aszklx3 106 1 We -PRON- PRP cord-335432-9aszklx3 106 2 commend commend VBP cord-335432-9aszklx3 106 3 it -PRON- PRP cord-335432-9aszklx3 106 4 to to IN cord-335432-9aszklx3 106 5 the the DT cord-335432-9aszklx3 106 6 community community NN cord-335432-9aszklx3 106 7 for for IN cord-335432-9aszklx3 106 8 discussion discussion NN cord-335432-9aszklx3 106 9 , , , cord-335432-9aszklx3 106 10 and and CC cord-335432-9aszklx3 106 11 if if IN cord-335432-9aszklx3 106 12 it -PRON- PRP cord-335432-9aszklx3 106 13 is be VBZ cord-335432-9aszklx3 106 14 found find VBN cord-335432-9aszklx3 106 15 useful useful JJ cord-335432-9aszklx3 106 16 , , , cord-335432-9aszklx3 106 17 we -PRON- PRP cord-335432-9aszklx3 106 18 encourage encourage VBP cord-335432-9aszklx3 106 19 its -PRON- PRP$ cord-335432-9aszklx3 106 20 adoption adoption NN cord-335432-9aszklx3 106 21 by by IN cord-335432-9aszklx3 106 22 scientists scientist NNS cord-335432-9aszklx3 106 23 , , , cord-335432-9aszklx3 106 24 governments government NNS cord-335432-9aszklx3 106 25 , , , cord-335432-9aszklx3 106 26 and and CC cord-335432-9aszklx3 106 27 the the DT cord-335432-9aszklx3 106 28 media medium NNS cord-335432-9aszklx3 106 29 . . . cord-335432-9aszklx3 107 1 It -PRON- PRP cord-335432-9aszklx3 107 2 might may MD cord-335432-9aszklx3 107 3 be be VB cord-335432-9aszklx3 107 4 aTRIP atrip JJ cord-335432-9aszklx3 107 5 , , , cord-335432-9aszklx3 108 1 but but CC cord-335432-9aszklx3 108 2 hopefully hopefully RB cord-335432-9aszklx3 108 3 it -PRON- PRP cord-335432-9aszklx3 108 4 is be VBZ cord-335432-9aszklx3 108 5 a a DT cord-335432-9aszklx3 108 6 trip trip NN cord-335432-9aszklx3 108 7 in in IN cord-335432-9aszklx3 108 8 the the DT cord-335432-9aszklx3 108 9 right right JJ cord-335432-9aszklx3 108 10 direction direction NN cord-335432-9aszklx3 108 11 . . . cord-335432-9aszklx3 109 1 Through through IN cord-335432-9aszklx3 109 2 the the DT cord-335432-9aszklx3 109 3 looking looking JJ cord-335432-9aszklx3 109 4 glass glass NN cord-335432-9aszklx3 109 5 , , , cord-335432-9aszklx3 109 6 and and CC cord-335432-9aszklx3 109 7 what what WP cord-335432-9aszklx3 109 8 Alice Alice NNP cord-335432-9aszklx3 109 9 found find VBD cord-335432-9aszklx3 109 10 there there RB cord-335432-9aszklx3 109 11 United United NNP cord-335432-9aszklx3 109 12 States States NNP cord-335432-9aszklx3 109 13 Government Government NNP cord-335432-9aszklx3 109 14 policy policy NN cord-335432-9aszklx3 109 15 for for IN cord-335432-9aszklx3 109 16 oversight oversight NN cord-335432-9aszklx3 109 17 of of IN cord-335432-9aszklx3 109 18 life life NN cord-335432-9aszklx3 109 19 sciences science NNS cord-335432-9aszklx3 109 20 dual dual JJ cord-335432-9aszklx3 109 21 use use NN cord-335432-9aszklx3 109 22 research research NN cord-335432-9aszklx3 109 23 of of IN cord-335432-9aszklx3 109 24 concern concern NN cord-335432-9aszklx3 109 25 Rescue Rescue NNP cord-335432-9aszklx3 109 26 of of IN cord-335432-9aszklx3 109 27 synthetic synthetic JJ cord-335432-9aszklx3 109 28 genomic genomic JJ cord-335432-9aszklx3 109 29 RNA RNA NNP cord-335432-9aszklx3 109 30 analogs analog NNS cord-335432-9aszklx3 109 31 of of IN cord-335432-9aszklx3 109 32 rabies rabie NNS cord-335432-9aszklx3 109 33 virus virus NN cord-335432-9aszklx3 109 34 by by IN cord-335432-9aszklx3 109 35 plasmid plasmid NN cord-335432-9aszklx3 109 36 - - HYPH cord-335432-9aszklx3 109 37 encoded encode VBN cord-335432-9aszklx3 109 38 proteins protein NNS cord-335432-9aszklx3 110 1 The the DT cord-335432-9aszklx3 110 2 Plowright Plowright NNP cord-335432-9aszklx3 110 3 vaccine vaccine NN cord-335432-9aszklx3 110 4 strain strain NN cord-335432-9aszklx3 110 5 of of IN cord-335432-9aszklx3 110 6 Rinderpest rinderpest NN cord-335432-9aszklx3 110 7 virus virus NN cord-335432-9aszklx3 110 8 has have VBZ cord-335432-9aszklx3 110 9 attenuating attenuate VBG cord-335432-9aszklx3 110 10 mutations mutation NNS cord-335432-9aszklx3 110 11 in in IN cord-335432-9aszklx3 110 12 most most JJS cord-335432-9aszklx3 110 13 genes gene NNS cord-335432-9aszklx3 110 14 Characterization characterization NN cord-335432-9aszklx3 110 15 of of IN cord-335432-9aszklx3 110 16 the the DT cord-335432-9aszklx3 110 17 reconstructed reconstructed JJ cord-335432-9aszklx3 110 18 1918 1918 CD cord-335432-9aszklx3 110 19 Spanish spanish JJ cord-335432-9aszklx3 110 20 influenza influenza NN cord-335432-9aszklx3 110 21 pandemic pandemic NN cord-335432-9aszklx3 110 22 virus virus NN cord-335432-9aszklx3 111 1 A a DT cord-335432-9aszklx3 111 2 strategy strategy NN cord-335432-9aszklx3 111 3 to to TO cord-335432-9aszklx3 111 4 estimate estimate VB cord-335432-9aszklx3 111 5 unknown unknown JJ cord-335432-9aszklx3 111 6 viral viral JJ cord-335432-9aszklx3 111 7 diversity diversity NN cord-335432-9aszklx3 111 8 in in IN cord-335432-9aszklx3 111 9 mammals mammal NNS cord-335432-9aszklx3 111 10 Risks risk NNS cord-335432-9aszklx3 111 11 and and CC cord-335432-9aszklx3 111 12 benefits benefit NNS cord-335432-9aszklx3 111 13 of of IN cord-335432-9aszklx3 111 14 gain gain NN cord-335432-9aszklx3 111 15 - - HYPH cord-335432-9aszklx3 111 16 of of IN cord-335432-9aszklx3 111 17 - - HYPH cord-335432-9aszklx3 111 18 function function NN cord-335432-9aszklx3 111 19 experiments experiment NNS cord-335432-9aszklx3 111 20 with with IN cord-335432-9aszklx3 111 21 pathogens pathogen NNS cord-335432-9aszklx3 111 22 of of IN cord-335432-9aszklx3 111 23 pandemic pandemic NN cord-335432-9aszklx3 111 24 potential potential NN cord-335432-9aszklx3 111 25 , , , cord-335432-9aszklx3 111 26 such such JJ cord-335432-9aszklx3 111 27 as as IN cord-335432-9aszklx3 111 28 influenza influenza NN cord-335432-9aszklx3 111 29 virus virus NN cord-335432-9aszklx3 111 30 : : : cord-335432-9aszklx3 111 31 a a DT cord-335432-9aszklx3 111 32 call call NN cord-335432-9aszklx3 111 33 for for IN cord-335432-9aszklx3 111 34 a a DT cord-335432-9aszklx3 111 35 science science NN cord-335432-9aszklx3 111 36 - - HYPH cord-335432-9aszklx3 111 37 based base VBN cord-335432-9aszklx3 111 38 discussion discussion NN cord-335432-9aszklx3 111 39 The the DT cord-335432-9aszklx3 111 40 views view NNS cord-335432-9aszklx3 111 41 expressed express VBN cord-335432-9aszklx3 111 42 in in IN cord-335432-9aszklx3 111 43 this this DT cord-335432-9aszklx3 111 44 article article NN cord-335432-9aszklx3 111 45 do do VBP cord-335432-9aszklx3 111 46 not not RB cord-335432-9aszklx3 111 47 necessarily necessarily RB cord-335432-9aszklx3 111 48 reflect reflect VB cord-335432-9aszklx3 111 49 the the DT cord-335432-9aszklx3 111 50 views view NNS cord-335432-9aszklx3 111 51 of of IN cord-335432-9aszklx3 111 52 the the DT cord-335432-9aszklx3 111 53 journal journal NN cord-335432-9aszklx3 111 54 or or CC cord-335432-9aszklx3 111 55 of of IN cord-335432-9aszklx3 111 56 ASM ASM NNP cord-335432-9aszklx3 112 1 We -PRON- PRP cord-335432-9aszklx3 112 2 are be VBP cord-335432-9aszklx3 112 3 very very RB cord-335432-9aszklx3 112 4 grateful grateful JJ cord-335432-9aszklx3 112 5 to to IN cord-335432-9aszklx3 112 6 Julie Julie NNP cord-335432-9aszklx3 112 7 Pfeiffer Pfeiffer NNP cord-335432-9aszklx3 112 8 , , , cord-335432-9aszklx3 112 9 UT UT NNP cord-335432-9aszklx3 112 10 Southwestern Southwestern NNP cord-335432-9aszklx3 112 11 Medical Medical NNP cord-335432-9aszklx3 112 12 Center Center NNP cord-335432-9aszklx3 112 13 , , , cord-335432-9aszklx3 112 14 Texas Texas NNP cord-335432-9aszklx3 112 15 , , , cord-335432-9aszklx3 112 16 for for IN cord-335432-9aszklx3 112 17 her -PRON- PRP$ cord-335432-9aszklx3 112 18 rendering rendering NN cord-335432-9aszklx3 112 19 of of IN cord-335432-9aszklx3 112 20 the the DT cord-335432-9aszklx3 112 21 gain gain NN cord-335432-9aszklx3 112 22 - - HYPH cord-335432-9aszklx3 112 23 of of IN cord-335432-9aszklx3 112 24 - - HYPH cord-335432-9aszklx3 112 25 function function NN cord-335432-9aszklx3 112 26 / / SYM cord-335432-9aszklx3 112 27 loss loss NN cord-335432-9aszklx3 112 28 - - HYPH cord-335432-9aszklx3 112 29 of of IN cord-335432-9aszklx3 112 30 - - HYPH cord-335432-9aszklx3 112 31 function function NN cord-335432-9aszklx3 112 32 Venn Venn NNP cord-335432-9aszklx3 112 33 diagram diagram NN cord-335432-9aszklx3 112 34 that that WDT cord-335432-9aszklx3 112 35 we -PRON- PRP cord-335432-9aszklx3 112 36 incorporated incorporate VBD cord-335432-9aszklx3 112 37 into into IN cord-335432-9aszklx3 112 38 the the DT cord-335432-9aszklx3 112 39 figure figure NN cord-335432-9aszklx3 112 40 associated associate VBN cord-335432-9aszklx3 112 41 with with IN cord-335432-9aszklx3 112 42 this this DT cord-335432-9aszklx3 112 43 editorial editorial NN cord-335432-9aszklx3 112 44 and and CC cord-335432-9aszklx3 112 45 for for IN cord-335432-9aszklx3 112 46 her -PRON- PRP$ cord-335432-9aszklx3 112 47 many many JJ cord-335432-9aszklx3 112 48 constructive constructive JJ cord-335432-9aszklx3 112 49 comments comment NNS cord-335432-9aszklx3 112 50 and and CC cord-335432-9aszklx3 112 51 useful useful JJ cord-335432-9aszklx3 112 52 suggestions suggestion NNS cord-335432-9aszklx3 112 53 . . . cord-335432-9aszklx3 113 1 Thanks thank NNS cord-335432-9aszklx3 113 2 go go VBP cord-335432-9aszklx3 113 3 to to IN cord-335432-9aszklx3 113 4 a a DT cord-335432-9aszklx3 113 5 large large JJ cord-335432-9aszklx3 113 6 number number NN cord-335432-9aszklx3 113 7 of of IN cord-335432-9aszklx3 113 8 colleagues colleague NNS cord-335432-9aszklx3 113 9 who who WP cord-335432-9aszklx3 113 10 responded respond VBD cord-335432-9aszklx3 113 11 to to IN cord-335432-9aszklx3 113 12 questions question NNS cord-335432-9aszklx3 113 13 about about IN cord-335432-9aszklx3 113 14 terminology terminology NN cord-335432-9aszklx3 113 15 and and CC cord-335432-9aszklx3 113 16 critiqued critique VBN cord-335432-9aszklx3 113 17 and and CC cord-335432-9aszklx3 113 18 canned canned JJ cord-335432-9aszklx3 113 19 suggestions suggestion NNS cord-335432-9aszklx3 113 20 which which WDT cord-335432-9aszklx3 113 21 never never RB cord-335432-9aszklx3 113 22 should should MD cord-335432-9aszklx3 113 23 have have VB cord-335432-9aszklx3 113 24 made make VBN cord-335432-9aszklx3 113 25 it -PRON- PRP cord-335432-9aszklx3 113 26 into into IN cord-335432-9aszklx3 113 27 print print NN cord-335432-9aszklx3 113 28 as as IN cord-335432-9aszklx3 113 29 we -PRON- PRP cord-335432-9aszklx3 113 30 flew fly VBD cord-335432-9aszklx3 113 31 some some DT cord-335432-9aszklx3 113 32 lexiconic lexiconic JJ cord-335432-9aszklx3 113 33 kites kite NNS cord-335432-9aszklx3 113 34 in in IN cord-335432-9aszklx3 113 35 their -PRON- PRP$ cord-335432-9aszklx3 113 36 faces face NNS cord-335432-9aszklx3 113 37 . . . cord-335432-9aszklx3 114 1 Finally finally RB cord-335432-9aszklx3 114 2 , , , cord-335432-9aszklx3 114 3 we -PRON- PRP cord-335432-9aszklx3 114 4 are be VBP cord-335432-9aszklx3 114 5 grateful grateful JJ cord-335432-9aszklx3 114 6 to to IN cord-335432-9aszklx3 114 7 Lewis Lewis NNP cord-335432-9aszklx3 114 8 Carroll Carroll NNP cord-335432-9aszklx3 114 9 , , , cord-335432-9aszklx3 114 10 a a DT cord-335432-9aszklx3 114 11 veritable veritable JJ cord-335432-9aszklx3 114 12 purveyor purveyor NN cord-335432-9aszklx3 114 13 of of IN cord-335432-9aszklx3 114 14 nonsense nonsense NN cord-335432-9aszklx3 114 15 and and CC cord-335432-9aszklx3 114 16 master master NN cord-335432-9aszklx3 114 17 of of IN cord-335432-9aszklx3 114 18 a a DT cord-335432-9aszklx3 114 19 rollicking rollicking JJ cord-335432-9aszklx3 114 20 TRIP trip NN cord-335432-9aszklx3 114 21 . . .